Wasf2 (WASP family member 2) - Rat Genome Database

Name: Wasf2
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: Wasf2 (WASP family member 2) Rattus norvegicus

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Symbol:

Wasf2

Name:

WASP family member 2

RGD ID:

1307299

Description:

Predicted to enable SH3 domain binding activity and protein kinase A binding activity. Predicted to be involved in negative regulation of stress fiber assembly; positive regulation of lamellipodium assembly; and postsynaptic actin cytoskeleton organization. Predicted to act upstream of or within several processes, including Rac protein signal transduction; lamellipodium organization; and megakaryocyte development. Predicted to be located in several cellular components, including early endosome; lamellipodium; and ruffle. Predicted to be part of SCAR complex. Predicted to be active in synapse. Orthologous to human WASF2 (WASP family member 2); PARTICIPATES IN E-cadherin signaling pathway; platelet-derived growth factor signaling pathway; Fc gamma receptor mediated signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 2,6-dinitrotoluene.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

actin-binding protein WASF2; LOC313024; MGC105905; WAS protein family, member 2; wiskott-Aldrich syndrome protein family member 2

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	WASF2 (WASP family member 2)	HGNC	Ensembl, Inparanoid, NCBI, OMA, OrthoDB, Panther
Mus musculus (house mouse):	Wasf2 (WASP family, member 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Wasf2 (WASP family member 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	WASF2 (WASP family member 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	WASF2 (WASP family member 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Wasf2 (WASP family member 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	WASF2 (WASP family member 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	WASF2 (WASP family member 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Wasf2 (WASP family member 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	FASTKD3 (FAST kinase domains 3)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	WASF2 (WASP family member 2)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Wasf2 (WASP family, member 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	wasf2 (WAS protein family, member 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	SCAR	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	wve-1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|PANTHER\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	wasf2	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	150,620,733 - 150,685,943 (+)	NCBI		GRCr8
mRatBN7.2	5	145,336,817 - 145,402,041 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	145,336,842 - 145,399,242 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	5	148,040,184 - 148,105,496 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	149,809,789 - 149,875,091 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	149,794,754 - 149,859,973 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	151,319,382 - 151,385,051 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	151,343,493 - 151,381,238 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	5	155,027,690 - 155,047,061 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	5	151,930,683 - 151,948,752 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	5	151,940,654 - 151,958,791 (-)	NCBI
Celera	5	143,800,446 - 143,819,945 (+)	NCBI		Celera
Cytogenetic Map	5	q36	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-epigallocatechin 3-gallate (ISO)

1,2-dimethylhydrazine (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-dinitrotoluene (EXP)

2,6-dinitrotoluene (EXP)

3,4-methylenedioxymethamphetamine (ISO)

4,4'-sulfonyldiphenol (EXP)

acetamide (EXP)

aflatoxin B1 (ISO)

Aflatoxin B2 alpha (ISO)

all-trans-retinoic acid (ISO)

alpha-Zearalanol (EXP)

arsenite(3-) (ISO)

atrazine (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

bisphenol F (EXP,ISO)

butan-1-ol (ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

caffeine (ISO)

cannabidiol (EXP)

carbon nanotube (ISO)

carmustine (ISO)

CGP 52608 (ISO)

chloroprene (EXP)

cobalt dichloride (ISO)

cyclosporin A (ISO)

Di-n-octyl phthalate (ISO)

dicrotophos (ISO)

dioxygen (ISO)

diuron (EXP)

dorsomorphin (ISO)

elemental selenium (ISO)

epoxiconazole (ISO)

ethanol (ISO)

ethyl methanesulfonate (ISO)

fenamidone (ISO)

fenthion (ISO)

formaldehyde (ISO)

FR900359 (ISO)

glyphosate (ISO)

isobutanol (ISO)

ivermectin (ISO)

lead diacetate (ISO)

lipopolysaccharide (ISO)

manganese(II) chloride (ISO)

methamphetamine (ISO)

methyl methanesulfonate (ISO)

methylmercury chloride (ISO)

paracetamol (EXP,ISO)

paraquat (ISO)

perfluorooctanoic acid (EXP)

potassium chromate (ISO)

resveratrol (ISO)

SB 431542 (ISO)

selenium atom (ISO)

sodium arsenite (ISO)

sulforaphane (ISO)

temozolomide (ISO)

thimerosal (ISO)

thioacetamide (EXP)

thiram (ISO)

titanium dioxide (ISO)

triticonazole (EXP)

tungsten (ISO)

valproic acid (ISO)

vitamin E (ISO)

vorinostat (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

actin cytoskeleton organization (IBA,ISO)

actin filament-based movement (ISO)

ameboidal-type cell migration (ISO)

angiogenesis (ISO)

cell motility (ISO)

endocytosis (ISO)

lamellipodium assembly (ISO)

lamellipodium morphogenesis (ISO)

megakaryocyte development (ISO)

negative regulation of stress fiber assembly (ISO)

positive regulation of Arp2/3 complex-mediated actin nucleation (IBA)

positive regulation of lamellipodium assembly (ISO)

postsynapse organization (ISO)

postsynaptic actin cytoskeleton organization (ISO)

Rac protein signal transduction (ISO)

Cellular Component

cell-cell junction (ISO)

cytoskeleton (IEA)

early endosome (ISO)

lamellipodium (IBA,ISO)

protein-containing complex (ISO)

ruffle (ISO)

SCAR complex (IBA,ISO)

synapse (ISO)

Molecular Function

actin binding (IEA)

Arp2/3 complex binding (IBA)

protein binding (ISO)

protein kinase A binding (ISO)

protein kinase A regulatory subunit binding (IBA)

SH3 domain binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

E-cadherin signaling pathway (ISO)

Fc gamma receptor mediated signaling pathway (IEA)

platelet-derived growth factor signaling pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
4.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
5.	PID Annotation Import Pipeline	Pipeline to import Pathway Interaction Database annotations from NCI into RGD
6.	GOA pipeline	RGD automated data pipeline
7.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
9.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.

Additional References at PubMed

PMID:12446704	PMID:12853475	PMID:12879075	PMID:15659545	PMID:15673667	PMID:17101133	PMID:17664349	PMID:18560548	PMID:18701695	PMID:19798448	PMID:20458337	PMID:20531346
PMID:21107423	PMID:23533145	PMID:23793062	PMID:23843614	PMID:25097019	PMID:25468996	PMID:28252024	PMID:33800361

Genomics

Comparative Map Data

Wasf2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	150,620,733 - 150,685,943 (+)	NCBI		GRCr8
mRatBN7.2	5	145,336,817 - 145,402,041 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	145,336,842 - 145,399,242 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	5	148,040,184 - 148,105,496 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	149,809,789 - 149,875,091 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	149,794,754 - 149,859,973 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	151,319,382 - 151,385,051 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	151,343,493 - 151,381,238 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	5	155,027,690 - 155,047,061 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	5	151,930,683 - 151,948,752 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	5	151,940,654 - 151,958,791 (-)	NCBI
Celera	5	143,800,446 - 143,819,945 (+)	NCBI		Celera
Cytogenetic Map	5	q36	NCBI

WASF2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	27,404,230 - 27,490,167 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	27,404,230 - 27,490,167 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	27,730,734 - 27,816,678 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	27,604,713 - 27,689,256 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	1	27,416,267 - 27,500,811	NCBI
Celera	1	26,129,424 - 26,213,972 (-)	NCBI		Celera
Cytogenetic Map	1	p36.11	NCBI
HuRef	1	25,986,791 - 26,072,767 (-)	NCBI		HuRef
CHM1_1	1	27,845,480 - 27,932,073 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	1	27,245,554 - 27,331,475 (-)	NCBI		T2T-CHM13v2.0

Wasf2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	4	132,857,843 - 132,927,067 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	4	132,857,816 - 132,927,067 (+)	Ensembl		GRCm39 Ensembl
GRCm38	4	133,130,531 - 133,199,748 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	4	133,130,505 - 133,199,756 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	4	132,686,548 - 132,754,245 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	4	132,402,709 - 132,470,406 (+)	NCBI		MGSCv36	mm8
Celera	4	131,287,726 - 131,363,266 (+)	NCBI		Celera
Cytogenetic Map	4	D2.3	NCBI
cM Map	4	66.22	NCBI

Wasf2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955452	6,658,854 - 6,680,084 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955452	6,658,854 - 6,733,964 (-)	NCBI	ChiLan1.0	ChiLan1.0

WASF2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	199,363,090 - 199,447,898 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	198,479,506 - 198,564,582 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	26,665,853 - 26,750,618 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	27,713,611 - 27,796,304 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	27,717,538 - 27,737,316 (-)	Ensembl	panpan1.1		panPan2

WASF2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	2	72,800,959 - 72,873,728 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	2	72,850,525 - 72,872,403 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	2	69,377,973 - 69,450,865 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	2	73,362,170 - 73,435,297 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	2	73,362,214 - 73,435,298 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	2	70,188,441 - 70,261,511 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	2	71,199,742 - 71,272,857 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	2	72,196,025 - 72,269,045 (+)	NCBI		UU_Cfam_GSD_1.0

Wasf2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	45,886,742 - 45,911,191 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936474	11,711,582 - 11,735,897 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936474	11,711,582 - 11,736,154 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

WASF2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	84,622,800 - 84,697,429 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	6	84,621,742 - 84,697,428 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	78,192,951 - 78,289,075 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

WASF2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	105,300,429 - 105,387,246 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	20	105,300,368 - 105,383,314 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666033	11,071,723 - 11,162,063 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Wasf2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624764	11,292,272 - 11,383,386 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624764	11,292,677 - 11,392,202 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Wasf2
307 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	34
Count of miRNA genes:	33
Interacting mature miRNAs:	34
Transcripts:	ENSRNOT00000067801
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1331796	Thshl2	Thyroid stimulating hormone level QTL 2	2.3		blood thyroid-stimulating hormone amount (VT:0005119)	serum thyroid stimulating hormone level (CMO:0001248)	5	97059760	147465714	Rat
10053720	Scort26	Serum corticosterone level QTL 26	2.06	0.0147	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	5	124965598	166875058	Rat
2302369	Scl60	Serum cholesterol level QTL 60	3.13		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	5	143608201	161165651	Rat
1549845	Scl44	Serum cholesterol level QTL 44	6		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	5	40128307	148607290	Rat
8552960	Pigfal15	Plasma insulin-like growth factor 1 level QTL 15			blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	5	111416838	156416838	Rat
631562	Apr2	Acute phase response QTL 2	3.7		blood murinoglobulin 1 amount (VT:0010597)	plasma murinoglobulin 1 level (CMO:0001931)	5	135927956	166875058	Rat
61444	Strs2	Sensitivity to stroke QTL 2	4.7		cerebrum integrity trait (VT:0010549)	post-insult time to onset of cerebrovascular lesion (CMO:0002343)	5	135929696	166875058	Rat
1300119	Bp180	Blood pressure QTL 180	3.82		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	5	144358090	157869054	Rat
70156	Niddm30	Non-insulin dependent diabetes mellitus QTL 30	3.98		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	5	129132447	151006154	Rat
8552908	Pigfal4	Plasma insulin-like growth factor 1 level QTL 4	6.6		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	5	128506074	166875058	Rat
61393	Bp7	Blood pressure QTL 7	4.5	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	60293434	161481680	Rat
7794791	Mcs33	Mammary carcinoma susceptibility QTL 33	1.93		mammary gland integrity trait (VT:0010552)	mammary tumor incidence/prevalence measurement (CMO:0000946)	5	131345754	166875058	Rat
7207486	Bss109	Bone structure and strength QTL 109			femur strength trait (VT:0010010)	femur total energy absorbed before break (CMO:0001677)	5	106906205	151906205	Rat
7207481	Bss106	Bone structure and strength QTL 106	7.9		femur strength trait (VT:0010010)	femur ultimate force (CMO:0001675)	5	106906205	151906205	Rat
1302790	Scl20	Serum cholesterol level QTL 20	6.4	0.0001	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	5	82394392	166664054	Rat
1598861	Cm64	Cardiac mass QTL 64	2.9		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	5	127798274	166875058	Rat
631263	Cm24	Cardiac mass QTL 24	3.5		heart mass (VT:0007028)	heart left ventricle weight to body weight ratio (CMO:0000530)	5	143799107	158428037	Rat
1578766	Tcas11	Tongue tumor susceptibility QTL 11	4.12		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	5	46711509	161317411	Rat
631505	Bp103	Blood pressure QTL 103	3.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	132717196	165560427	Rat
1641920	Colcs1	Colorectal carcinoma susceptibility QTL 1	2.99	0.0055	intestine integrity trait (VT:0010554)	benign colorectal tumor surface area measurement (CMO:0001799)	5	121846814	166846814	Rat
1549838	Bss4	Bone structure and strength QTL 4	9.2		femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	5	106906205	151906205	Rat
1331721	Bp210	Blood pressure QTL 210	3.413		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	5	143069996	166846814	Rat
8694169	Bw148	Body weight QTL 148	5	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	5	128506074	166875058	Rat
8657050	Bw146	Body weight QTL 146	19.84	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	5	108938288	153938288	Rat
1576314	Eutr1	Estrogen induced uterine response QTL 1			uterus integrity trait (VT:0010575)	pyometritis severity score (CMO:0002009)	5	2138965	166875058	Rat
2317056	Wbc3	White blood cell count QTL 3	2.51	0.01	leukocyte quantity (VT:0000217)	white blood cell count (CMO:0000027)	5	105999803	150999803	Rat
634349	Bp139	Blood pressure QTL 139		0.001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	128924607	166875058	Rat
724525	Bp147	Blood pressure QTL 147	4.3	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	126424772	166875058	Rat
1598847	Cm62	Cardiac mass QTL 62	3.4		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	5	108845856	153845856	Rat
2293642	Bss37	Bone structure and strength QTL 37	4.64	0.0001	femur strength trait (VT:0010010)	femur ultimate force (CMO:0001675)	5	120740824	151018848	Rat
738018	Anxrr4	Anxiety related response QTL 4	5.1		exploratory behavior trait (VT:0010471)	percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)	5	130130159	166875058	Rat
1578673	Bmd13	Bone mineral density QTL 13	4.9		femur mineral mass (VT:0010011)	trabecular volumetric bone mineral density (CMO:0001729)	5	103689353	148689353	Rat
2313096	Bmd78	Bone mineral density QTL 78	3.1	0.0001	tibia mineral mass (VT:1000283)	total volumetric bone mineral density (CMO:0001728)	5	144377876	161317411	Rat
8694441	Bw169	Body weight QTL 169	17.61	0.001	retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	5	111416838	156416838	Rat
7207488	Bss110	Bone structure and strength QTL 1	8.4		femur strength trait (VT:0010010)	femur stiffness (CMO:0001674)	5	106906205	151906205	Rat
7207491	Bss112	Bone structure and strength QTL 112	7		femur morphology trait (VT:0000559)	femur midshaft cortical cross-sectional area (CMO:0001663)	5	106906205	151906205	Rat
8694389	Bw160	Body weight QTL 160	6.17	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	5	111416838	156416838	Rat
1354598	Srn6	Serum renin concentration QTL 6	3.8		blood renin amount (VT:0003349)	plasma renin activity level (CMO:0000116)	5	69540295	151018848	Rat
8694198	Abfw3	Abdominal fat weight QTL 3	16.13	0.001	visceral adipose mass (VT:0010063)	abdominal fat pad weight to body weight ratio (CMO:0000095)	5	111416838	156416838	Rat
1298089	Scl14	Serum cholesterol level QTL 14	5.8	0.0004	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	5	108845856	153845856	Rat
1598819	Bp292	Blood pressure QTL 292	4.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	127798274	166875058	Rat
1358187	Emca1	Estrogen-induced mammary cancer QTL 1	4.4		mammary gland integrity trait (VT:0010552)	post-insult time to mammary tumor formation (CMO:0000345)	5	99216724	148607142	Rat

Markers in Region

BF400119

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	5	145,385,722 - 145,385,883 (+)	MAPPER	mRatBN7.2
Rnor_6.0	5	151,368,766 - 151,368,926	NCBI	Rnor6.0
Rnor_5.0	5	155,034,838 - 155,034,998	UniSTS	Rnor5.0
RGSC_v3.4	5	151,941,444 - 151,941,604	UniSTS	RGSC3.4
Celera	5	143,807,594 - 143,807,754	UniSTS
RH 3.4 Map	5	977.9	UniSTS
Cytogenetic Map	5	q36	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001013167	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001394051	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008764138	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039109781	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039109782	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039109783	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC089207	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473968	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000005	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000067801 ⟹ ENSRNOP00000063111

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	5	145,336,842 - 145,399,242 (+)	Ensembl
Rnor_6.0 Ensembl	5	151,362,064 - 151,381,111 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000077083 ⟹ ENSRNOP00000073555

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	5	145,336,844 - 145,399,242 (+)	Ensembl
Rnor_6.0 Ensembl	5	151,362,019 - 151,381,238 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000077807 ⟹ ENSRNOP00000069489

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	5	151,343,493 - 151,380,055 (+)	Ensembl

RefSeq Acc Id:

NM_001013167 ⟹ NP_001013185

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	150,662,485 - 150,685,943 (+)	NCBI
mRatBN7.2	5	145,378,575 - 145,402,037 (+)	NCBI
Rnor_6.0	5	151,361,618 - 151,381,240 (+)	NCBI
Rnor_5.0	5	155,027,690 - 155,047,061 (+)	NCBI
RGSC_v3.4	5	151,930,683 - 151,948,752 (-)	RGD
Celera	5	143,800,446 - 143,819,945 (+)	RGD

Sequence:

show sequence

CTCCCTGCTACAGAGGTTGTTTTTCATCACTGAGAACCTTGCCTGAAGCAGGTCCACTATGCCC
TTAGTAACCAGGAACATCGAGCCAAGGCACCTGTGCCGTCAGACGTTGCCTAGCGATACAAGCG
AGCTGGAATGCAGGACCAACATCACCCTGGCAAATGTCATCCGACAGCTGGGCAGCCTGAGTAA
GTATGCGGAGGACATTTTCGGAGAGATTTGTACTCAGGCAAGTGCCTTTGCCTCCCGAGTGAAC
TCCCTTGCTGAGCGGGTTGACCGGGTACAAGTTAAAGTCACTCAGCTGGATCCCAAGGAAGAAG
AAGTGTCACTGCAAGGAATCAACACTCGTAAGGCCTTCAGAAGCTCTACCATCCAAGACCAGAA
GCTTTTTGACAGAAATTCCCTTCCAGTACCAGTCTTGGAAACCTATAACAGCTGTGACGCTCCT
CCTCCTCTTAACAATCTAAGTCCTTACAGGGACGACGGAAAAGAGGCGCTCAAATTCTACACCA
ACCCTTCGTACTTCTTTGATCTTTGGAAGGAGAAGATGCTGCAGGACACCAAGGATATCATGAA
AGAGAAGAGAAAGCACAGGAAAGAAAAGAAAGATAATCCAAACAGAGGGAATGTGAACCCACGT
AAAATCAAGACACGCAAGGAAGAGTGGGAGAAGATGAAAATGGGACAAGAATTTGTGGAGTCCA
AGGAGAAGCTGGGGCCTTCTGGATACTCGCCCGCCTTGGTGTACCAGAATGGCAACTTTGGCTC
TGTTGAAAACGTGGATGCGACAAGCTACCCACCACCGCCACAGTCGGACTCTGCCTCCTCACCT
TCCCCTTCATTCTCTGATGACAACTTGCCTCCCCCACCAGCAGAATTCAGCTACCCTGCAGACA
ACCAAAGAGGATCTGTCTTGGCTGGACCCAAGAGAACCAGCATGGTCAGCCCAAGCCATCCACC
CCCAGCTCCTCCTCTGAGCTCCCCGCCAGGTCCCAAACCTGGCTTTGCCCCTCCACCTGCCCCT
CCACCTCCACCTCCAATGAGCGTGCCGCCTCCACTGCCATCTGTAGGATTCGGGTCTCCTGGGA
CCCCTCCACCACCCTCGCCTCCCTCTTTCCCTCCCCACCCTGACTTTGCTGCTCCTCCACCACC
TCCCCCTCCACCAGCAGCTGACTACCCAATGCCACCACCTCCCTTGTCCCAACCATCTGGAGGC
GCTCCTCCGCCTCCCCCTCCCCCTCCCCCTCCAGGGCCCCCACCTCTTCCCTTGGGTGGTGCTG
ATGGCCAGCCTGCAGCTCCACCACCACCTCCTGTTTCTGATGCCGCCAAGCCCAAGTCTTCGTT
GCCTGCTGTGAGTGATGCTCGTAGTGACCTGCTTTCTGCCATCCGCCAAGGCTTTCAACTGCGA
AGGGTTGAAGAGCAGCGGGAGCAAGAGAAGCGTGATGTGGTGGGCAATGATGTGGCCACCATCC
TGTCCCGGCGAATTGCTGTTGAGTACAGCGACTCAGAAGACGACTCCTCTGAATTTGATGAAGA
TGACTGGTCGGATTAACTGCCTTTTGCCCACATTCCTCCTTCTGCTCTCCCCACCCGCCTTCTC
AGATACAAACTGTAACAGTCTCATGTGGGGAAGGAAGAAAGGACAAAGAACTGCAAGGGGCCAA
AGCCTTCTCTGGAAAAAAAAAAAAAAAAAAAAAAAAAAAGG

hide sequence

RefSeq Acc Id:

NM_001394051 ⟹ NP_001380980

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	150,620,733 - 150,685,943 (+)	NCBI
mRatBN7.2	5	145,336,817 - 145,402,037 (+)	NCBI

RefSeq Acc Id:

XM_039109781 ⟹ XP_038965709

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	150,661,043 - 150,685,943 (+)	NCBI
mRatBN7.2	5	145,377,106 - 145,402,041 (+)	NCBI

RefSeq Acc Id:

XM_039109782 ⟹ XP_038965710

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	150,643,396 - 150,685,943 (+)	NCBI
mRatBN7.2	5	145,361,103 - 145,402,041 (+)	NCBI

RefSeq Acc Id:

XM_039109783 ⟹ XP_038965711

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	150,643,396 - 150,685,943 (+)	NCBI
mRatBN7.2	5	145,360,531 - 145,402,041 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001013185	(Get FASTA)	NCBI Sequence Viewer
	NP_001380980	(Get FASTA)	NCBI Sequence Viewer
	XP_038965709	(Get FASTA)	NCBI Sequence Viewer
	XP_038965710	(Get FASTA)	NCBI Sequence Viewer
	XP_038965711	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH89207	(Get FASTA)	NCBI Sequence Viewer
	EDL80659	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000063111.4
	ENSRNOP00000073555.2

RefSeq Acc Id:

NP_001013185 ⟸ NM_001013167

- UniProtKB:

Q5FWU0 (UniProtKB/TrEMBL), E9PTF9 (UniProtKB/TrEMBL), A0A0G2K5T9 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MPLVTRNIEPRHLCRQTLPSDTSELECRTNITLANVIRQLGSLSKYAEDIFGEICTQASAFASR
VNSLAERVDRVQVKVTQLDPKEEEVSLQGINTRKAFRSSTIQDQKLFDRNSLPVPVLETYNSCD
APPPLNNLSPYRDDGKEALKFYTNPSYFFDLWKEKMLQDTKDIMKEKRKHRKEKKDNPNRGNVN
PRKIKTRKEEWEKMKMGQEFVESKEKLGPSGYSPALVYQNGNFGSVENVDATSYPPPPQSDSAS
SPSPSFSDDNLPPPPAEFSYPADNQRGSVLAGPKRTSMVSPSHPPPAPPLSSPPGPKPGFAPPP
APPPPPPMSVPPPLPSVGFGSPGTPPPPSPPSFPPHPDFAAPPPPPPPPAADYPMPPPPLSQPS
GGAPPPPPPPPPPGPPPLPLGGADGQPAAPPPPPVSDAAKPKSSLPAVSDARSDLLSAIRQGFQ
LRRVEEQREQEKRDVVGNDVATILSRRIAVEYSDSEDDSSEFDEDDWSD

hide sequence

Ensembl Acc Id:

ENSRNOP00000073555 ⟸ ENSRNOT00000077083

Ensembl Acc Id:

ENSRNOP00000063111 ⟸ ENSRNOT00000067801

Ensembl Acc Id:

ENSRNOP00000069489 ⟸ ENSRNOT00000077807

RefSeq Acc Id:	XP_038965711 ⟸ XM_039109783
- Peptide Label:	isoform X1
- UniProtKB:	E9PTF9 (UniProtKB/TrEMBL), Q5FWU0 (UniProtKB/TrEMBL), A0A0G2K5T9 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038965710 ⟸ XM_039109782
- Peptide Label:	isoform X1
- UniProtKB:	E9PTF9 (UniProtKB/TrEMBL), Q5FWU0 (UniProtKB/TrEMBL), A0A0G2K5T9 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038965709 ⟸ XM_039109781
- Peptide Label:	isoform X1
- UniProtKB:	E9PTF9 (UniProtKB/TrEMBL), Q5FWU0 (UniProtKB/TrEMBL), A0A0G2K5T9 (UniProtKB/TrEMBL)

RefSeq Acc Id:	NP_001380980 ⟸ NM_001394051
- UniProtKB:	E9PTF9 (UniProtKB/TrEMBL), Q5FWU0 (UniProtKB/TrEMBL), A0A0G2K5T9 (UniProtKB/TrEMBL)

Protein Domains

WH2

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-A0A0G2K5T9-F1-model_v2	AlphaFold	A0A0G2K5T9	1-494	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1307299	AgrOrtholog
BioCyc Gene	G2FUF-39642	BioCyc
Ensembl Genes	ENSRNOG00000009805	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000067801.4	UniProtKB/TrEMBL
	ENSRNOT00000077083.2	UniProtKB/TrEMBL
Gene3D-CATH	1.20.5.340	UniProtKB/TrEMBL
	6.10.280.150	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7135528	IMAGE-MGC_LOAD
InterPro	SCAR/WAVE_fam	UniProtKB/TrEMBL
	WH2_dom	UniProtKB/TrEMBL
KEGG Report	rno:313024	UniProtKB/TrEMBL
MGC_CLONE	MGC:105905	IMAGE-MGC_LOAD
NCBI Gene	313024	ENTREZGENE
PANTHER	PTHR12902	UniProtKB/TrEMBL
	WISKOTT-ALDRICH SYNDROME PROTEIN FAMILY MEMBER 2	UniProtKB/TrEMBL
Pfam	WH2	UniProtKB/TrEMBL
PhenoGen	Wasf2	PhenoGen
PRINTS	PRICHEXTENSN	UniProtKB/TrEMBL
PROSITE	WH2	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000009805	RatGTEx
SMART	WH2	UniProtKB/TrEMBL
Superfamily-SCOP	Duffy binding domain-like	UniProtKB/TrEMBL
UniProt	A0A0G2K5T9	ENTREZGENE, UniProtKB/TrEMBL
	A6ISV8_RAT	UniProtKB/TrEMBL
	E9PTF9	ENTREZGENE
	Q5FWU0	ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary	E9PTF9	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2019-04-02	Wasf2	WASP family member 2	Wasf2	WAS protein family, member 2	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-12-06	Wasf2	WAS protein family, member 2	Wasf2_predicted	WAS protein family, member 2 (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-12	Wasf2_predicted	WAS protein family, member 2 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Annotations - KEGG (archival)

Imported Annotations - PID (archival)

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Imported Annotations - KEGG (archival)

Imported Annotations - PID (archival)