Zeb2 (zinc finger E-box binding homeobox 2) - Rat Genome Database

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Gene: Zeb2 (zinc finger E-box binding homeobox 2) Rattus norvegicus
Analyze
Symbol: Zeb2
Name: zinc finger E-box binding homeobox 2
RGD ID: 1307272
Description: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; R-SMAD binding activity; and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including myofibroblast differentiation; positive regulation of myofibroblast contraction; and stress fiber assembly. Predicted to be located in cytosol; nucleolus; and nucleoplasm. Predicted to be part of chromatin. Biomarker of myocardial infarction; proteinuria; and rheumatic heart disease. Human ortholog(s) of this gene implicated in Hirschsprung's disease and Mowat-Wilson syndrome. Orthologous to human ZEB2 (zinc finger E-box binding homeobox 2); INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC311071; Zfhx1b; zinc finger E-box-binding homeobox 2; zinc finger homeobox 1b
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Is Marker For: Strains:   F344-Zeb2em1Kyo  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8349,624,028 - 49,754,323 (-)NCBIGRCr8
mRatBN7.2329,214,581 - 29,344,890 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl329,218,301 - 29,345,157 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx332,612,891 - 32,735,232 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0341,197,919 - 41,320,278 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0339,016,630 - 39,138,985 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0329,857,289 - 29,985,932 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl329,862,473 - 29,996,865 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0335,058,725 - 35,186,767 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4325,513,009 - 25,654,964 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1325,409,380 - 25,556,869 (-)NCBI
Celera327,525,557 - 27,647,939 (-)NCBICelera
Cytogenetic Map3q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP,ISO)
(-)-demecolcine  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2-acetamidofluorene  (EXP)
2-butoxyethanol  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3,7-dihydropurine-6-thione  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-Nitrobenzanthrone  (ISO)
4,4'-diaminodiphenylmethane  (EXP,ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (ISO)
acetamide  (EXP)
acrolein  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
angiotensin II  (EXP)
antimycin A  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP,ISO)
carbamazepine  (ISO)
chlordecone  (ISO)
chloroprene  (EXP,ISO)
cholesterol  (ISO)
choline  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
Cuprizon  (EXP)
deguelin  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
diazinon  (EXP)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP)
dimethyl sulfoxide  (ISO)
disodium selenite  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (ISO)
entinostat  (ISO)
ethanol  (ISO)
flusilazole  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
gentamycin  (EXP)
indole-3-methanol  (EXP)
indometacin  (ISO)
L-methionine  (ISO)
levonorgestrel  (ISO)
lithocholic acid  (ISO)
mercaptopurine  (EXP)
mercury dibromide  (ISO)
methoxychlor  (EXP)
methylmercury chloride  (ISO)
MK-2206  (ISO)
N-nitrosodimethylamine  (EXP)
nickel subsulfide  (EXP)
okadaic acid  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
p-chloromercuribenzoic acid  (ISO)
p-toluidine  (EXP)
paracetamol  (EXP,ISO)
PCB138  (EXP)
perfluorodecanoic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (EXP,ISO)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
picoxystrobin  (ISO)
potassium dichromate  (ISO)
progesterone  (ISO)
purine-6-thiol  (EXP)
pyrimidifen  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sorafenib  (ISO)
streptozocin  (ISO)
succimer  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
testosterone  (EXP)
testosterone undecanoate  (ISO)
tetrachloromethane  (ISO)
thifluzamide  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
troglitazone  (ISO)
valproic acid  (EXP,ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
astrocyte activation  (IDA)
cell proliferation in forebrain  (ISO)
central nervous system development  (ISO)
collateral sprouting  (ISO)
corpus callosum morphogenesis  (ISO)
corticospinal tract morphogenesis  (ISO)
developmental pigmentation  (ISO)
embryonic morphogenesis  (ISO)
endothelial cell migration  (IMP)
endothelial cell proliferation  (IMP)
fibroblast activation  (IDA)
hippocampus development  (ISO)
mammillary axonal complex development  (ISO)
melanocyte migration  (ISO)
myofibroblast differentiation  (IEP)
negative regulation of fibroblast migration  (IDA)
negative regulation of transcription by RNA polymerase II  (ISO)
neural crest cell migration  (ISO)
neural tube closure  (ISO)
positive regulation of axonogenesis  (ISO)
positive regulation of canonical Wnt signaling pathway  (ISO)
positive regulation of lens fiber cell differentiation  (ISO)
positive regulation of melanocyte differentiation  (ISO)
positive regulation of myofibroblast contraction  (IDA)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of transforming growth factor beta receptor signaling pathway  (ISO)
positive regulation of Wnt signaling pathway  (ISO)
pyroptotic inflammatory response  (IDA)
regulation of blood-brain barrier permeability  (IMP)
regulation of melanosome organization  (ISO)
regulation of myofibroblast cell apoptotic process  (IMP)
regulation of transcription by RNA polymerase II  (IBA)
response to oxygen-glucose deprivation  (IMP)
somitogenesis  (ISO)
stress fiber assembly  (IMP)

Cellular Component
chromatin  (ISO)
cytosol  (IEA,ISO)
nucleolus  (IEA,ISO)
nucleoplasm  (IEA,ISO)
nucleus  (ISO)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
astrocytosis  (IMP)
gliosis  (IMP)
References

References - curated
# Reference Title Reference Citation
1. The Ski-Zeb2-Meox2 pathway provides a novel mechanism for regulation of the cardiac myofibroblast phenotype. Cunnington RH, etal., J Cell Sci. 2014 Jan 1;127(Pt 1):40-9. doi: 10.1242/jcs.126722. Epub 2013 Oct 23.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. ZEB2, interacting with MDM2, contributes to the dysfuntion of brain microvascular endothelial cells and brain injury after intracerebral hemorrhage. Guo Q, etal., Cell Cycle. 2021 Sep;20(17):1692-1707. doi: 10.1080/15384101.2021.1959702. Epub 2021 Aug 2.
5. The Functional Role of Zinc Finger E Box-Binding Homeobox 2 (Zeb2) in Promoting Cardiac Fibroblast Activation. Jahan F, etal., Int J Mol Sci. 2018 Oct 17;19(10):3207. doi: 10.3390/ijms19103207.
6. MicroRNA-200c-3p inhibits proliferation and migration of renal artery endothelial cells by directly targeting ZEB2. Liu Y, etal., Exp Cell Res. 2020 Feb 15;387(2):111778. doi: 10.1016/j.yexcr.2019.111778. Epub 2019 Dec 25.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Cerebral ischemia induces TRPC6 via HIF1α/ZEB2 axis in the glomerular podocytes and contributes to proteinuria. Nakuluri K, etal., Sci Rep. 2019 Nov 29;9(1):17897. doi: 10.1038/s41598-019-52872-5.
9. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
10. GOA pipeline RGD automated data pipeline
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Comprehensive gene review and curation RGD comprehensive gene curation
14. Involvement of renal corpuscle microRNA expression on epithelial-to-mesenchymal transition in maternal low protein diet in adult programmed rats. Sene Lde B, etal., PLoS One. 2013 Aug 19;8(8):e71310. doi: 10.1371/journal.pone.0071310. eCollection 2013.
15. Long Non-Coding RNA SOX2 Overlapping Transcript Aggravates H9c2 Cell Injury via the miR-215-5p/ZEB2 Axis and Promotes Ischemic Heart Failure in a Rat Model. Tu J, etal., Tohoku J Exp Med. 2021 Jul;254(3):221-231. doi: 10.1620/tjem.254.221.
16. Mutations in SIP1, encoding Smad interacting protein-1, cause a form of Hirschsprung disease. Wakamatsu N, etal., Nat Genet. 2001 Apr;27(4):369-70.
17. Activation of activin/Smad2 and 3 signaling pathway and the potential involvement of endothelial‑mesenchymal transition in the valvular damage due to rheumatic heart disease. Xian S, etal., Mol Med Rep. 2021 Jan;23(1):10. doi: 10.3892/mmr.2020.11648. Epub 2020 Nov 12.
18. Zinc finger E-Box binding homeobox 2 (ZEB2)-induced astrogliosis protected neuron from pyroptosis in cerebral ischemia and reperfusion injury. Zhao Z, etal., Bioengineered. 2021 Dec;12(2):12917-12930. doi: 10.1080/21655979.2021.2012551.
Additional References at PubMed
PMID:12522767   PMID:12837246   PMID:16115198   PMID:16157277   PMID:16162653   PMID:16598713   PMID:17644613   PMID:20516212   PMID:22012804   PMID:22082260   PMID:23001561   PMID:24769727  
PMID:25741725   PMID:26550927   PMID:30238984   PMID:30479019   PMID:36880168   PMID:37391399  


Genomics

Comparative Map Data
Zeb2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8349,624,028 - 49,754,323 (-)NCBIGRCr8
mRatBN7.2329,214,581 - 29,344,890 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl329,218,301 - 29,345,157 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx332,612,891 - 32,735,232 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0341,197,919 - 41,320,278 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0339,016,630 - 39,138,985 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0329,857,289 - 29,985,932 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl329,862,473 - 29,996,865 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0335,058,725 - 35,186,767 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4325,513,009 - 25,654,964 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1325,409,380 - 25,556,869 (-)NCBI
Celera327,525,557 - 27,647,939 (-)NCBICelera
Cytogenetic Map3q12NCBI
ZEB2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382144,384,081 - 144,520,119 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2144,364,364 - 144,521,057 (-)EnsemblGRCh38hg38GRCh38
GRCh372145,141,648 - 145,277,686 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362144,862,053 - 144,994,386 (-)NCBINCBI36Build 36hg18NCBI36
Build 342144,979,316 - 145,111,648NCBI
Celera2138,854,690 - 138,990,641 (-)NCBICelera
Cytogenetic Map2q22.3NCBI
HuRef2137,133,063 - 137,270,287 (-)NCBIHuRef
CHM1_12145,147,224 - 145,283,048 (-)NCBICHM1_1
T2T-CHM13v2.02144,832,138 - 144,968,126 (-)NCBIT2T-CHM13v2.0
Zeb2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39244,873,523 - 45,007,378 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl244,873,644 - 45,007,407 (-)EnsemblGRCm39 Ensembl
GRCm38244,983,512 - 45,117,442 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl244,983,632 - 45,117,395 (-)EnsemblGRCm38mm10GRCm38
MGSCv37244,839,154 - 44,968,799 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36244,805,741 - 44,935,025 (-)NCBIMGSCv36mm8
Celera246,695,993 - 46,825,633 (-)NCBICelera
Cytogenetic Map2BNCBI
cM Map227.31NCBI
Zeb2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544010,756,014 - 10,795,491 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495544010,755,658 - 10,881,044 (-)NCBIChiLan1.0ChiLan1.0
ZEB2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21330,393,494 - 30,525,791 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B30,408,606 - 30,544,307 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B15,325,094 - 15,460,908 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B148,460,904 - 148,596,500 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B148,460,904 - 148,596,500 (-)Ensemblpanpan1.1panPan2
ZEB2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11946,419,812 - 46,541,888 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1946,423,998 - 46,542,122 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1946,620,546 - 46,746,041 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01947,879,894 - 48,018,072 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1947,884,370 - 48,018,038 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11946,537,396 - 46,674,974 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01946,668,918 - 46,806,835 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01948,064,344 - 48,202,432 (-)NCBIUU_Cfam_GSD_1.0
Zeb2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303109,245,435 - 109,376,990 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493646932,240,835 - 32,371,267 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493646932,240,730 - 32,372,413 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ZEB2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl157,499,026 - 7,632,655 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1157,498,879 - 7,631,347 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2157,946,943 - 8,069,149 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ZEB2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11029,732,934 - 29,864,157 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1029,729,305 - 29,864,205 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040169,693,241 - 169,827,578 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Zeb2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473244,101,613 - 44,139,997 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473244,097,348 - 44,226,701 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Zeb2
448 total Variants
miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mir200arno-miR-200a-3pMirtarbaseexternal_infoWestern blotFunctional MTI19167416
Mir192rno-miR-192-5pMirtarbaseexternal_infoqRT-PCR//Luciferase reporter assay//Western blotFunctional MTI20393144
Mir200brno-miR-200b-3pMirtarbaseexternal_infoWestern blotFunctional MTI19167416
Mir200brno-miR-200b-3pMirtarbaseexternal_infoWestern blotFunctional MTI18942116

Predicted Target Of
Summary Value
Count of predictions:33
Count of miRNA genes:32
Interacting mature miRNAs:33
Transcripts:ENSRNOT00000006350
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
6893355Bw101Body weight QTL 1010.40.38body mass (VT:0001259)body weight (CMO:0000012)31077870430357018Rat
2302055Pia30Pristane induced arthritis QTL 303.50.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)32793691972936919Rat
1298073Cm13Cardiac mass QTL 132.5heart mass (VT:0007028)heart wet weight (CMO:0000069)32501391138192233Rat
2303593Gluco46Glucose level QTL 463blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)32846857173468571Rat
1354590Despr11Despair related QTL 110.000031locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)32846857173468571Rat
634306Bp140Blood pressure QTL 1403.30.0013arterial blood pressure trait (VT:2000000)body weight (CMO:0000012)31737470335528639Rat
10401810Kidm53Kidney mass QTL 53kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3822719447233430Rat
1298526Arunc3Aerobic running capacity QTL 32.2exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)3822719433703538Rat
2298542Neuinf11Neuroinflammation QTL 113.9nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)31500542276927699Rat
631832Sach1Saccharin preference QTL 12.70.02consumption behavior trait (VT:0002069)calculated saccharin drink intake volume (CMO:0001600)32749462144188411Rat
2313079Bss73Bone structure and strength QTL 731.5tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)32749462150302886Rat
1558657Cm43Cardiac mass QTL 436.63e-08heart mass (VT:0007028)heart wet weight (CMO:0000069)31077882330356773Rat
2313076Bss74Bone structure and strength QTL 7420.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)32749462150302886Rat
631568Bp92Blood pressure QTL 922.20.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3139874793Rat
6893363Bw105Body weight QTL 1052.60.0036body mass (VT:0001259)body weight (CMO:0000012)31077870430357018Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)pulse pressure (CMO:0000292)3133278763Rat
9590286Uminl1Urine mineral level QTL 13.50.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)32824968773249687Rat
631831Alc8Alcohol consumption QTL 82.7consumption behavior trait (VT:0002069)calculated ethanol drink intake rate (CMO:0001615)3133230976Rat
1558647Cm46Cardiac mass QTL 465.40.0000055heart mass (VT:0007028)heart wet weight (CMO:0000069)31077882330356773Rat
4889966Bss95Bone structure and strength QTL 954.4tibia area (VT:1000281)tibia-fibula cross-sectional area (CMO:0001718)3136847613Rat
2313093Bmd77Bone mineral density QTL 772.20.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)32749462150302886Rat
12879852Cm93Cardiac mass QTL 930.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)31831145447233430Rat
1558654Bw56Body weight QTL 564.50.0000171body mass (VT:0001259)body weight (CMO:0000012)31077870430357018Rat
12879853Am5Aortic mass QTL 50.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)31831145447233430Rat
12879854Kidm63Kidney mass QTL 630.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)31831145447233430Rat
9590136Scort3Serum corticosterone level QTL 323.370.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)32824968773249687Rat
10450804Scl70Serum cholesterol level QTL 704.70.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)32071409065714090Rat
1558650Cm48Cardiac mass QTL 4840.0001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)31077882330356773Rat
1358905Hrtrt17Heart rate QTL 175.90.000014heart pumping trait (VT:2000009)heart rate (CMO:0000002)31086191289878372Rat
12879849Bw180Body weight QTL 1800.037body mass (VT:0001259)body weight (CMO:0000012)31831145447233430Rat
70191BpQTLcluster4Blood pressure QTL cluster 43arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)31077870450302886Rat
12879850Cm91Cardiac mass QTL 910.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)31831145447233430Rat
2313101Bmd76Bone mineral density QTL 763.60.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)32749462150302886Rat
731172Bp151Blood pressure QTL 1510.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31831145447233430Rat
12879851Cm92Cardiac mass QTL 920.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)31831145447233430Rat
631545Bp85Blood pressure QTL 853.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3133278763Rat
8694196Abfw2Abdominal fat weight QTL 216.580.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)32824968773249687Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
8552950Pigfal12Plasma insulin-like growth factor 1 level QTL 127.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)32824968773249687Rat
631676Cm8Cardiac mass QTL 87.030.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)31695470861954708Rat
10450794Scl69Serum cholesterol level QTL 696.30.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)32071409065714090Rat
631679Cm10Cardiac mass QTL 107.340.0001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3131158234Rat
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)3191609953Rat
8694386Bw159Body weight QTL 1594.520.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)32824968773249687Rat
2313049Bss72Bone structure and strength QTL 722.60.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)32749462150302886Rat
2312664Scl62Serum cholesterol level QTL 620.05blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)3138710544Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat

Markers in Region
SHGC-35092  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2329,302,260 - 29,302,408 (+)MAPPERmRatBN7.2
Rnor_6.0329,945,187 - 29,945,334NCBIRnor6.0
Rnor_5.0335,146,389 - 35,146,536UniSTSRnor5.0
RGSC_v3.4325,614,926 - 25,615,073UniSTSRGSC3.4
Celera327,608,163 - 27,608,310UniSTS
Cytogenetic Map3q12UniSTS
RH98161  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2329,264,413 - 29,264,654 (+)MAPPERmRatBN7.2
Rnor_6.0329,907,356 - 29,907,596NCBIRnor6.0
Rnor_5.0335,108,580 - 35,108,820UniSTSRnor5.0
RGSC_v3.4325,558,481 - 25,558,721UniSTSRGSC3.4
Celera327,570,284 - 27,570,524UniSTS
Cytogenetic Map3q12UniSTS
RH142990  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2329,226,073 - 29,226,354 (+)MAPPERmRatBN7.2
Rnor_6.0329,868,782 - 29,869,062NCBIRnor6.0
Rnor_5.0335,070,218 - 35,070,498UniSTSRnor5.0
RGSC_v3.4325,519,354 - 25,519,634UniSTSRGSC3.4
Celera327,531,865 - 27,532,145UniSTS
RH 3.4 Map3341.41UniSTS
Cytogenetic Map3q12UniSTS
BE111861  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2329,283,683 - 29,283,896 (+)MAPPERmRatBN7.2
Rnor_6.0329,926,612 - 29,926,824NCBIRnor6.0
Rnor_5.0335,127,814 - 35,128,026UniSTSRnor5.0
RGSC_v3.4325,595,805 - 25,596,017UniSTSRGSC3.4
Celera327,589,595 - 27,589,807UniSTS
RH 3.4 Map3360.0UniSTS
Cytogenetic Map3q12UniSTS
RH137572  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2329,228,464 - 29,228,587 (+)MAPPERmRatBN7.2
Rnor_6.0329,871,173 - 29,871,295NCBIRnor6.0
Rnor_5.0335,072,609 - 35,072,731UniSTSRnor5.0
RGSC_v3.4325,521,745 - 25,521,867UniSTSRGSC3.4
Celera327,534,256 - 27,534,378UniSTS
RH 3.4 Map3362.5UniSTS
Cytogenetic Map3q12UniSTS
RH141197  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2329,337,318 - 29,337,499 (+)MAPPERmRatBN7.2
Rnor_6.0329,988,997 - 29,989,177NCBIRnor6.0
Rnor_5.0335,188,275 - 35,188,455UniSTSRnor5.0
RGSC_v3.4325,650,246 - 25,650,426UniSTSRGSC3.4
Celera327,643,257 - 27,643,437UniSTS
Cytogenetic Map3q12UniSTS


Related Rat Strains
The following Strains have been annotated to Zeb2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1 38 31 17 17 17 8 8 74 31 35 11 8
Low 2 5 26 24 2 24 3 4 6
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000006350   ⟹   ENSRNOP00000006350
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl329,218,301 - 29,342,362 (-)Ensembl
Rnor_6.0 Ensembl329,862,473 - 29,984,201 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000080382   ⟹   ENSRNOP00000074730
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl329,224,150 - 29,345,157 (-)Ensembl
Rnor_6.0 Ensembl329,866,812 - 29,996,865 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000085801   ⟹   ENSRNOP00000072515
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl329,219,339 - 29,256,136 (-)Ensembl
Rnor_6.0 Ensembl329,862,473 - 29,993,715 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000096459   ⟹   ENSRNOP00000086279
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl329,218,301 - 29,345,157 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000108531   ⟹   ENSRNOP00000077035
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl329,218,301 - 29,345,157 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000108969   ⟹   ENSRNOP00000084801
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl329,219,188 - 29,345,157 (-)Ensembl
RefSeq Acc Id: NM_001033701   ⟹   NP_001028873
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8349,624,028 - 49,754,323 (-)NCBI
mRatBN7.2329,214,581 - 29,344,890 (-)NCBI
Rnor_6.0329,862,473 - 29,984,201 (-)NCBI
Rnor_5.0335,058,725 - 35,186,767 (-)NCBI
RGSC_v3.4325,513,009 - 25,654,964 (-)RGD
Celera327,525,557 - 27,647,939 (-)RGD
Sequence:
RefSeq Acc Id: XM_017591687   ⟹   XP_017447176
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8349,629,743 - 49,751,526 (-)NCBI
mRatBN7.2329,220,274 - 29,342,094 (-)NCBI
Rnor_6.0329,862,967 - 29,984,270 (-)NCBI
Sequence:
RefSeq Acc Id: NP_001028873   ⟸   NM_001033701
- UniProtKB: Q3T921 (UniProtKB/TrEMBL),   A0A8I6GES1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017447176   ⟸   XM_017591687
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K8T6 (UniProtKB/TrEMBL),   Q3T921 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000006350   ⟸   ENSRNOT00000006350
RefSeq Acc Id: ENSRNOP00000074730   ⟸   ENSRNOT00000080382
RefSeq Acc Id: ENSRNOP00000072515   ⟸   ENSRNOT00000085801
RefSeq Acc Id: ENSRNOP00000086279   ⟸   ENSRNOT00000096459
RefSeq Acc Id: ENSRNOP00000077035   ⟸   ENSRNOT00000108531
RefSeq Acc Id: ENSRNOP00000084801   ⟸   ENSRNOT00000108969
Protein Domains
C2H2-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-E9PTC3-F1-model_v2 AlphaFold E9PTC3 1-1215 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692065
Promoter ID:EPDNEW_R2588
Type:multiple initiation site
Name:Zeb2_2
Description:zinc finger E-box binding homeobox 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R2590  EPDNEW_R2589  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0329,993,719 - 29,993,779EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307272 AgrOrtholog
BioCyc Gene G2FUF-49837 BioCyc
Ensembl Genes ENSRNOG00000004677 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000006350.5 UniProtKB/TrEMBL
  ENSRNOT00000080382.2 UniProtKB/TrEMBL
  ENSRNOT00000085801.2 UniProtKB/TrEMBL
  ENSRNOT00000096459.1 UniProtKB/TrEMBL
  ENSRNOT00000108531.1 UniProtKB/TrEMBL
  ENSRNOT00000108969.1 UniProtKB/TrEMBL
Gene3D-CATH Classic Zinc Finger UniProtKB/TrEMBL
  Homeodomain-like UniProtKB/TrEMBL
InterPro Di19_Zn_binding UniProtKB/TrEMBL
  Homeobox UniProtKB/TrEMBL
  Homeodomain-like UniProtKB/TrEMBL
  Znf_C2H2/integrase_DNA-bd UniProtKB/TrEMBL
  Znf_C2H2_sf UniProtKB/TrEMBL
KEGG Report rno:311071 UniProtKB/TrEMBL
NCBI Gene 311071 ENTREZGENE
PANTHER GM08392P UniProtKB/TrEMBL
  HISTONE H4 TRANSCRIPTION FACTOR-RELATED UniProtKB/TrEMBL
  ZINC FINGER E-BOX-BINDING HOMEOBOX 2 UniProtKB/TrEMBL
  ZINC FINGER PROTEIN UniProtKB/TrEMBL
  ZINC FINGER PROTEIN 1 UniProtKB/TrEMBL
Pfam zf-C2H2 UniProtKB/TrEMBL
  zf-Di19 UniProtKB/TrEMBL
  zf-met UniProtKB/TrEMBL
PhenoGen Zeb2 PhenoGen
PROSITE ZINC_FINGER_C2H2_1 UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000004677 RatGTEx
SMART HOX UniProtKB/TrEMBL
  ZnF_C2H2 UniProtKB/TrEMBL
Superfamily-SCOP Homeodomain_like UniProtKB/TrEMBL
  SSF57667 UniProtKB/TrEMBL
UniProt A0A0G2K363_RAT UniProtKB/TrEMBL
  A0A0G2K8T6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5YC43_RAT UniProtKB/TrEMBL
  A0A8I6A027_RAT UniProtKB/TrEMBL
  A0A8I6GES1 ENTREZGENE, UniProtKB/TrEMBL
  E9PTC3_RAT UniProtKB/TrEMBL
  Q3T921 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-04 Zeb2  zinc finger E-box binding homeobox 2  Zfhx1b  zinc finger homeobox 1b  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Zfhx1b  zinc finger homeobox 1b  Zfhx1b_predicted  zinc finger homeobox 1b (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Zfhx1b_predicted  zinc finger homeobox 1b (predicted)      Symbol and Name status set to approved 70820 APPROVED