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Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Clic3 | Rat | 1,1-dichloroethene | decreases expression | ISO | Clic3 (Mus musculus) | 6480464 | vinylidene chloride results in decreased expression of CLIC3 mRNA | CTD | PMID:26682919 | Clic3 | Rat | 17alpha-ethynylestradiol | decreases expression | ISO | Clic3 (Mus musculus) | 6480464 | Ethinyl Estradiol results in decreased expression of CLIC3 mRNA | CTD | PMID:17555576 | Clic3 | Rat | 17beta-estradiol | multiple interactions | ISO | CLIC3 (Homo sapiens) | 6480464 | [Progesterone co-treated with Estradiol] results in decreased expression of CLIC3 mRNA; EGF protein inhibits the more ... | CTD | PMID:17404688|PMID:24758408 | Clic3 | Rat | 17beta-estradiol | decreases expression | ISO | CLIC3 (Homo sapiens) | 6480464 | Estradiol results in decreased expression of CLIC3 mRNA | CTD | PMID:30165855|PMID:31614463 | Clic3 | Rat | 17beta-estradiol | increases expression | ISO | CLIC3 (Homo sapiens) | 6480464 | Estradiol results in increased expression of CLIC3 mRNA | CTD | PMID:24758408 | Clic3 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | Clic3 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin results in increased expression of CLIC3 mRNA | CTD | PMID:17035482 | Clic3 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of CLIC3 mRNA | CTD | PMID:33387578 | Clic3 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | CLIC3 (Homo sapiens) | 6480464 | Tetrachlorodibenzodioxin results in increased expression of CLIC3 mRNA | CTD | PMID:20106945|PMID:21632981 | Clic3 | Rat | 2,4-dibromophenyl 2,4,5-tribromophenyl ether | affects expression | ISO | Clic3 (Mus musculus) | 6480464 | 2,2',4,4',5-brominated diphenyl ether affects the expression of CLIC3 mRNA | CTD | PMID:38648751 | Clic3 | Rat | 2,6-dimethoxyphenol | multiple interactions | ISO | CLIC3 (Homo sapiens) | 6480464 | [pyrogallol 1,3-dimethyl ether co-treated with Furaldehyde] results in decreased expression of and affects the localization more ... | CTD | PMID:38598786 | Clic3 | Rat | 2-hydroxypropanoic acid | decreases expression | ISO | CLIC3 (Homo sapiens) | 6480464 | Lactic Acid results in decreased expression of CLIC3 mRNA | CTD | PMID:30851411 | Clic3 | Rat | 3,3',4,4',5-pentachlorobiphenyl | increases expression | EXP | | 6480464 | 3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CLIC3 mRNA | CTD | PMID:23196670 | Clic3 | Rat | 3,4-methylenedioxymethamphetamine | decreases expression | ISO | Clic3 (Mus musculus) | 6480464 | N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of CLIC3 mRNA | CTD | PMID:20188158 | Clic3 | Rat | 3-isobutyl-1-methyl-7H-xanthine | multiple interactions | ISO | CLIC3 (Homo sapiens) | 6480464 | [Dexamethasone co-treated with 8-Bromo Cyclic Adenosine Monophosphate co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of more ... | CTD | PMID:16997883 | Clic3 | Rat | 8-Br-cAMP | multiple interactions | ISO | CLIC3 (Homo sapiens) | 6480464 | [Dexamethasone co-treated with 8-Bromo Cyclic Adenosine Monophosphate co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of more ... | CTD | PMID:16997883 | Clic3 | Rat | 8-Br-cAMP | increases expression | ISO | CLIC3 (Homo sapiens) | 6480464 | 8-Bromo Cyclic Adenosine Monophosphate results in increased expression of CLIC3 mRNA | CTD | PMID:22079614 | Clic3 | Rat | acrylamide | increases expression | EXP | | 6480464 | Acrylamide results in increased expression of CLIC3 mRNA | CTD | PMID:28959563 | Clic3 | Rat | afimoxifene | increases expression | ISO | CLIC3 (Homo sapiens) | 6480464 | afimoxifene results in increased expression of CLIC3 mRNA | CTD | PMID:16849584 | Clic3 | Rat | aflatoxin B1 | decreases expression | ISO | CLIC3 (Homo sapiens) | 6480464 | Aflatoxin B1 results in decreased expression of CLIC3 mRNA | CTD | PMID:21641981 | Clic3 | Rat | all-trans-retinoic acid | decreases expression | ISO | CLIC3 (Homo sapiens) | 6480464 | Tretinoin results in decreased expression of CLIC3 mRNA | CTD | PMID:23830798 | Clic3 | Rat | ampicillin | increases expression | ISO | CLIC3 (Homo sapiens) | 6480464 | Ampicillin results in increased expression of CLIC3 mRNA | CTD | PMID:21632981 | Clic3 | Rat | Aroclor 1254 | increases expression | ISO | Clic3 (Mus musculus) | 6480464 | Chlorodiphenyl (54% Chlorine) results in increased expression of CLIC3 mRNA | CTD | PMID:23650126 | Clic3 | Rat | arsenous acid | multiple interactions | ISO | CLIC3 (Homo sapiens) | 6480464 | Arsenic Trioxide inhibits the reaction [4-aminophenylarsenoxide binds to CLIC3 protein] | CTD | PMID:26598702 | Clic3 | Rat | benzo[a]pyrene | decreases expression | ISO | CLIC3 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased expression of CLIC3 mRNA | CTD | PMID:21632981 | Clic3 | Rat | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of CLIC3 mRNA | CTD | PMID:25181051|PMID:34947998 | Clic3 | Rat | bisphenol A | increases methylation | EXP | | 6480464 | bisphenol A results in increased methylation of CLIC3 gene | CTD | PMID:28505145 | Clic3 | Rat | bisphenol A | decreases expression | ISO | CLIC3 (Homo sapiens) | 6480464 | bisphenol A results in decreased expression of CLIC3 mRNA | CTD | PMID:27685785 | Clic3 | Rat | butanal | increases expression | ISO | CLIC3 (Homo sapiens) | 6480464 | butyraldehyde results in increased expression of CLIC3 mRNA | CTD | PMID:26079696 | Clic3 | Rat | cadmium dichloride | increases methylation | EXP | | 6480464 | Cadmium Chloride results in increased methylation of CLIC3 promoter | CTD | PMID:22457795 | Clic3 | Rat | cadmium dichloride | increases expression | ISO | CLIC3 (Homo sapiens) | 6480464 | Cadmium Chloride results in increased expression of CLIC3 mRNA | CTD | PMID:38174414 | Clic3 | Rat | calcium dichloride | decreases expression | ISO | CLIC3 (Homo sapiens) | 6480464 | Calcium Chloride results in decreased expression of CLIC3 protein | CTD | PMID:25824407 | Clic3 | Rat | carbon nanotube | decreases expression | ISO | Clic3 (Mus musculus) | 6480464 | Nanotubes, Carbon analog results in decreased expression of CLIC3 mRNA; Nanotubes, Carbon results in decreased more ... | CTD | PMID:25620056 | Clic3 | Rat | chromium(6+) | multiple interactions | ISO | CLIC3 (Homo sapiens) | 6480464 | [zinc chromate results in increased abundance of chromium hexavalent ion] which results in decreased expression more ... | CTD | PMID:38479592 | Clic3 | Rat | clofibrate | decreases expression | ISO | Clic3 (Mus musculus) | 6480464 | Clofibrate results in decreased expression of CLIC3 mRNA | CTD | PMID:17585979 | Clic3 | Rat | copper atom | multiple interactions | ISO | CLIC3 (Homo sapiens) | 6480464 | [NSC 689534 binds to Copper] which results in increased expression of CLIC3 mRNA | CTD | PMID:20971185 | Clic3 | Rat | copper(0) | multiple interactions | ISO | CLIC3 (Homo sapiens) | 6480464 | [NSC 689534 binds to Copper] which results in increased expression of CLIC3 mRNA | CTD | PMID:20971185 | Clic3 | Rat | copper(II) chloride | decreases expression | ISO | CLIC3 (Homo sapiens) | 6480464 | cupric chloride results in decreased expression of CLIC3 mRNA | CTD | PMID:38568856 | Clic3 | Rat | copper(II) sulfate | decreases expression | ISO | CLIC3 (Homo sapiens) | 6480464 | Copper Sulfate results in decreased expression of CLIC3 mRNA | CTD | PMID:19549813 | Clic3 | Rat | crocidolite asbestos | increases expression | ISO | CLIC3 (Homo sapiens) | 6480464 | Asbestos, Crocidolite results in increased expression of CLIC3 mRNA | CTD | PMID:25351596 | Clic3 | Rat | cyclosporin A | decreases expression | ISO | CLIC3 (Homo sapiens) | 6480464 | Cyclosporine results in decreased expression of CLIC3 mRNA | CTD | PMID:20106945|PMID:21632981|PMID:27989131 | Clic3 | Rat | DDE | decreases expression | ISO | CLIC3 (Homo sapiens) | 6480464 | Dichlorodiphenyl Dichloroethylene results in decreased expression of CLIC3 mRNA | CTD | PMID:38568856 | Clic3 | Rat | decabromodiphenyl ether | decreases expression | ISO | CLIC3 (Homo sapiens) | 6480464 | decabromobiphenyl ether results in decreased expression of CLIC3 protein | CTD | PMID:31675489 | Clic3 | Rat | deoxynivalenol | decreases expression | ISO | CLIC3 (Homo sapiens) | 6480464 | deoxynivalenol results in decreased expression of CLIC3 mRNA | CTD | PMID:31863870 | Clic3 | Rat | dexamethasone | multiple interactions | ISO | CLIC3 (Homo sapiens) | 6480464 | [Dexamethasone co-treated with 8-Bromo Cyclic Adenosine Monophosphate co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of more ... | CTD | PMID:16997883 | Clic3 | Rat | diarsenic trioxide | multiple interactions | ISO | CLIC3 (Homo sapiens) | 6480464 | Arsenic Trioxide inhibits the reaction [4-aminophenylarsenoxide binds to CLIC3 protein] | CTD | PMID:26598702 | Clic3 | Rat | Dibutyl phosphate | affects expression | ISO | CLIC3 (Homo sapiens) | 6480464 | di-n-butylphosphoric acid affects the expression of CLIC3 mRNA | CTD | PMID:37042841 | Clic3 | Rat | diuron | decreases expression | EXP | | 6480464 | Diuron results in decreased expression of CLIC3 mRNA | CTD | PMID:21551480 | Clic3 | Rat | endosulfan | decreases expression | EXP | | 6480464 | Endosulfan results in decreased expression of CLIC3 mRNA | CTD | PMID:29391264 | Clic3 | Rat | entinostat | increases expression | ISO | CLIC3 (Homo sapiens) | 6480464 | entinostat results in increased expression of CLIC3 mRNA | CTD | PMID:27188386 | Clic3 | Rat | ethanol | increases expression | EXP | | 6480464 | Ethanol results in increased expression of CLIC3 mRNA | CTD | PMID:31078653 | Clic3 | Rat | furfural | multiple interactions | ISO | CLIC3 (Homo sapiens) | 6480464 | [pyrogallol 1,3-dimethyl ether co-treated with Furaldehyde] results in decreased expression of and affects the localization more ... | CTD | PMID:38598786 | Clic3 | Rat | gentamycin | decreases expression | EXP | | 6480464 | Gentamicins results in decreased expression of CLIC3 mRNA | CTD | PMID:33387578 | Clic3 | Rat | GSK-J4 | decreases expression | ISO | CLIC3 (Homo sapiens) | 6480464 | GSK-J4 results in decreased expression of CLIC3 mRNA | CTD | PMID:29301935 | Clic3 | Rat | hydroquinone | increases expression | ISO | CLIC3 (Homo sapiens) | 6480464 | hydroquinone results in increased expression of CLIC3 mRNA | CTD | PMID:31256213 | Clic3 | Rat | nitrofen | increases expression | EXP | | 6480464 | nitrofen results in increased expression of CLIC3 mRNA | CTD | PMID:33484710 | Clic3 | Rat | paracetamol | increases expression | ISO | CLIC3 (Homo sapiens) | 6480464 | Acetaminophen results in increased expression of CLIC3 mRNA | CTD | PMID:22230336 | Clic3 | Rat | paracetamol | decreases expression | EXP | | 6480464 | Acetaminophen results in decreased expression of CLIC3 mRNA | CTD | PMID:33387578 | Clic3 | Rat | paraquat | decreases expression | EXP | | 6480464 | Paraquat results in decreased expression of CLIC3 mRNA | CTD | PMID:32680482 | Clic3 | Rat | potassium chromate | increases expression | ISO | CLIC3 (Homo sapiens) | 6480464 | potassium chromate(VI) results in increased expression of CLIC3 mRNA | CTD | PMID:22714537 | Clic3 | Rat | pregnenolone 16alpha-carbonitrile | decreases expression | ISO | Clic3 (Mus musculus) | 6480464 | Pregnenolone Carbonitrile results in decreased expression of CLIC3 mRNA | CTD | PMID:28903501 | Clic3 | Rat | progesterone | multiple interactions | ISO | CLIC3 (Homo sapiens) | 6480464 | [Progesterone co-treated with Estradiol] results in decreased expression of CLIC3 mRNA | CTD | PMID:17404688 | Clic3 | Rat | propanal | increases expression | ISO | CLIC3 (Homo sapiens) | 6480464 | propionaldehyde results in increased expression of CLIC3 mRNA | CTD | PMID:26079696 | Clic3 | Rat | rac-lactic acid | decreases expression | ISO | CLIC3 (Homo sapiens) | 6480464 | Lactic Acid results in decreased expression of CLIC3 mRNA | CTD | PMID:30851411 | Clic3 | Rat | serpentine asbestos | decreases expression | ISO | CLIC3 (Homo sapiens) | 6480464 | Asbestos, Serpentine results in decreased expression of CLIC3 mRNA | CTD | PMID:29523930 | Clic3 | Rat | silicon dioxide | decreases expression | ISO | CLIC3 (Homo sapiens) | 6480464 | Silicon Dioxide analog results in decreased expression of CLIC3 mRNA | CTD | PMID:23806026 | Clic3 | Rat | sodium arsenite | increases expression | ISO | CLIC3 (Homo sapiens) | 6480464 | sodium arsenite results in increased expression of CLIC3 mRNA | CTD | PMID:29301061 | Clic3 | Rat | sodium arsenite | decreases expression | ISO | Clic3 (Mus musculus) | 6480464 | sodium arsenite results in decreased expression of CLIC3 mRNA | CTD | PMID:37682722 | Clic3 | Rat | sodium chloride | multiple interactions | ISO | CLIC3 (Homo sapiens) | 6480464 | [Sodium Chloride co-treated with Furaldehyde] results in increased expression of and affects the localization of more ... | CTD | PMID:38598786 | Clic3 | Rat | sodium fluoride | decreases expression | ISO | Clic3 (Mus musculus) | 6480464 | Sodium Fluoride results in decreased expression of CLIC3 mRNA | CTD | PMID:27862939 | Clic3 | Rat | sulforaphane | decreases expression | ISO | CLIC3 (Homo sapiens) | 6480464 | sulforaphane results in decreased expression of CLIC3 mRNA | CTD | PMID:31838189 | Clic3 | Rat | tert-butyl hydroperoxide | decreases expression | ISO | CLIC3 (Homo sapiens) | 6480464 | tert-Butylhydroperoxide results in decreased expression of CLIC3 mRNA | CTD | PMID:15336504 | Clic3 | Rat | tetrachloroethene | decreases expression | ISO | Clic3 (Mus musculus) | 6480464 | Tetrachloroethylene results in decreased expression of CLIC3 mRNA | CTD | PMID:28973375 | Clic3 | Rat | trichloroethene | decreases expression | ISO | Clic3 (Mus musculus) | 6480464 | Trichloroethylene results in decreased expression of CLIC3 mRNA | CTD | PMID:28973375 | Clic3 | Rat | triclosan | increases expression | ISO | CLIC3 (Homo sapiens) | 6480464 | Triclosan results in increased expression of CLIC3 mRNA | CTD | PMID:30510588 | Clic3 | Rat | triphenyl phosphate | affects expression | ISO | CLIC3 (Homo sapiens) | 6480464 | triphenyl phosphate affects the expression of CLIC3 mRNA | CTD | PMID:37042841 | Clic3 | Rat | triptonide | increases expression | ISO | Clic3 (Mus musculus) | 6480464 | triptonide results in increased expression of CLIC3 mRNA | CTD | PMID:33045310 | Clic3 | Rat | triptonide | affects expression | ISO | Clic3 (Mus musculus) | 6480464 | triptonide affects the expression of CLIC3 mRNA | CTD | PMID:33045310 | Clic3 | Rat | urethane | decreases expression | ISO | CLIC3 (Homo sapiens) | 6480464 | Urethane results in decreased expression of CLIC3 mRNA | CTD | PMID:28818685 | Clic3 | Rat | valproic acid | increases methylation | ISO | CLIC3 (Homo sapiens) | 6480464 | Valproic Acid results in increased methylation of CLIC3 gene | CTD | PMID:29154799 | Clic3 | Rat | vinclozolin | affects expression | EXP | | 6480464 | vinclozolin affects the expression of CLIC3 mRNA | CTD | PMID:19015723 | |