Arhgap22 (Rho GTPase activating protein 22) - Rat Genome Database

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Gene: Arhgap22 (Rho GTPase activating protein 22) Rattus norvegicus
Analyze
Symbol: Arhgap22
Name: Rho GTPase activating protein 22
RGD ID: 1307237
Description: Predicted to enable GTPase activator activity. Predicted to be involved in regulation of postsynapse organization. Predicted to be active in glutamatergic synapse. Orthologous to human ARHGAP22 (Rho GTPase activating protein 22); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; acetamide; aflatoxin B1.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC306279; rho GTPase-activating protein 22
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8168,480,222 - 8,637,823 (+)NCBIGRCr8
mRatBN7.2168,473,806 - 8,631,552 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl168,476,306 - 8,631,548 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx168,600,860 - 8,650,867 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0169,745,577 - 9,795,573 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0168,595,355 - 8,645,379 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0169,454,269 - 9,613,508 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl169,486,832 - 9,613,528 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01611,414,640 - 11,572,157 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4168,863,537 - 8,913,459 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1168,866,751 - 8,913,458 (+)NCBI
Celera166,575,743 - 6,625,300 (-)NCBICelera
Cytogenetic Map16p16NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-diaminotoluene  (ISO)
2-palmitoylglycerol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
acetamide  (EXP)
aflatoxin B1  (EXP,ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
butanal  (ISO)
cadmium dichloride  (EXP)
chlorpyrifos  (ISO)
choline  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
dexamethasone  (ISO)
dibutyl phthalate  (EXP)
dorsomorphin  (ISO)
endosulfan  (EXP)
folic acid  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
furan  (EXP)
genistein  (ISO)
gentamycin  (EXP)
glyphosate  (EXP)
hydrogen peroxide  (ISO)
indometacin  (ISO)
L-methionine  (ISO)
lead(0)  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodiethylamine  (ISO)
orphenadrine  (EXP)
oxaliplatin  (EXP)
paracetamol  (EXP,ISO)
pentanal  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
propanal  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
Soman  (EXP)
tamoxifen  (ISO)
temozolomide  (ISO)
testosterone  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
triclosan  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:21423176   PMID:21926414  


Genomics

Comparative Map Data
Arhgap22
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8168,480,222 - 8,637,823 (+)NCBIGRCr8
mRatBN7.2168,473,806 - 8,631,552 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl168,476,306 - 8,631,548 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx168,600,860 - 8,650,867 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0169,745,577 - 9,795,573 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0168,595,355 - 8,645,379 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0169,454,269 - 9,613,508 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl169,486,832 - 9,613,528 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01611,414,640 - 11,572,157 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4168,863,537 - 8,913,459 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1168,866,751 - 8,913,458 (+)NCBI
Celera166,575,743 - 6,625,300 (-)NCBICelera
Cytogenetic Map16p16NCBI
ARHGAP22
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381048,429,831 - 48,656,265 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1048,446,036 - 48,656,265 (-)EnsemblGRCh38hg38GRCh38
GRCh371049,654,079 - 49,864,310 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361049,324,085 - 49,483,144 (-)NCBINCBI36Build 36hg18NCBI36
Build 341049,324,085 - 49,483,144NCBI
Celera1043,239,986 - 43,398,967 (-)NCBICelera
Cytogenetic Map10q11.22-q11.23NCBI
HuRef1043,918,892 - 44,129,417 (-)NCBIHuRef
CHM1_11049,935,899 - 50,146,144 (-)NCBICHM1_1
T2T-CHM13v2.01049,275,552 - 49,505,563 (-)NCBIT2T-CHM13v2.0
Arhgap22
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391432,935,952 - 33,091,893 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1432,935,983 - 33,091,891 (+)EnsemblGRCm39 Ensembl
GRCm381433,213,994 - 33,369,936 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1433,214,026 - 33,369,934 (+)EnsemblGRCm38mm10GRCm38
MGSCv371434,030,009 - 34,183,122 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361432,045,915 - 32,199,025 (+)NCBIMGSCv36mm8
Celera1429,476,997 - 29,628,675 (+)NCBICelera
Cytogenetic Map14BNCBI
cM Map1420.15NCBI
Arhgap22
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555561,501,773 - 1,588,604 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555561,462,366 - 1,588,589 (+)NCBIChiLan1.0ChiLan1.0
ARHGAP22
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2860,676,020 - 60,925,165 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11060,682,205 - 60,930,486 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01045,589,509 - 45,833,137 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
ARHGAP22
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.128419,532 - 555,511 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl28419,838 - 582,548 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha28648,824 - 784,583 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.028595,180 - 731,152 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl28595,483 - 758,607 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.128394,859 - 530,643 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.028436,100 - 571,773 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.028561,465 - 697,162 (-)NCBIUU_Cfam_GSD_1.0
Arhgap22
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721380,366,892 - 80,562,523 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367281,573,288 - 1,765,505 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367281,633,385 - 1,765,345 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ARHGAP22
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1489,113,768 - 89,331,274 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11489,113,774 - 89,331,629 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21496,946,248 - 97,088,885 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ARHGAP22
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1943,140,076 - 43,349,962 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl943,316,598 - 43,349,602 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660482,901,664 - 3,117,756 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Arhgap22
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046249281,265,592 - 1,433,947 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Arhgap22
1519 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:65
Count of miRNA genes:56
Interacting mature miRNAs:63
Transcripts:ENSRNOT00000035915
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357403Slep4Serum leptin concentration QTL 43.91blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1619639137Rat
1600369Hcas8Hepatocarcinoma susceptibility QTL 8liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)16122477621Rat
631830Alc7Alcohol consumption QTL 72.9consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16126727669Rat
634355Rends4Renal damage susceptibility QTL 40.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)16126727669Rat
1582235Insul8Insulin level QTL 83.30.0063blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)16126727669Rat
9590151Scort8Serum corticosterone level QTL 88.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)16130836262Rat
2302380Slep6Serum leptin concentration QTL 63.36blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)16132139025Rat
2307172Activ4Activity QTL 43.710.00023locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)16133418960Rat
1354584Despr6Despair related QTL 63.10.0067locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16139533930Rat
2303566Bw90Body weight QTL 902body mass (VT:0001259)body weight (CMO:0000012)16139533930Rat
631561Hcuc2Hepatic copper content QTL 22.8liver copper amount (VT:0003065)liver total copper weight (CMO:0001507)16139533949Rat
6903319Bw114Body weight QTL 1142.70.0037body mass (VT:0001259)body weight (CMO:0000012)16143534949Rat
7411664Foco30Food consumption QTL 30110.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)16144588133Rat
1354625Despr7Despair related QTL 73.160.016locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16144977551Rat
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)1638024580345693Rat
2293343Glom16Glomerulus QTL 167.4kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1683223646053497Rat
2312660Bw95Body weight QTL 950.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)1683223659492508Rat
2312663Slep9Serum leptin concentration QTL 90.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1683223659492508Rat
2312666Insul16Insulin level QTL 160.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1683223659492508Rat
2312669Stl23Serum triglyceride level QTL 230.01blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1683223659492508Rat
2301406Kidm39Kidney mass QTL 390.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)16285170915884239Rat
1300133Rf24Renal function QTL 243.64blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)16338015021361552Rat
2306902Bp339Blood pressure QTL 3390.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16338015043025077Rat
737825Alc13Alcohol consumption QTL 134.5consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16422760916039848Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)16422760943025077Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16422760943025077Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)16422760943025077Rat
737819Hcas4Hepatocarcinoma susceptibility QTL 44.43liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)16422760946975965Rat
61405Niddm6Non-insulin dependent diabetes mellitus QTL 63.660.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)16422760948972724Rat
61338Bp23Blood pressure QTL 234.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16422760949227609Rat
737826Alc11Alcohol consumption QTL 113.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16422760960252231Rat
61372Bp40Blood pressure QTL 402.2blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)16422773017696785Rat

Markers in Region
D16Rat83  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2168,627,567 - 8,627,782 (+)MAPPERmRatBN7.2
Rnor_6.0169,609,524 - 9,609,738NCBIRnor6.0
Rnor_5.01611,568,173 - 11,568,387UniSTSRnor5.0
RGSC_v3.4168,909,479 - 8,909,694RGDRGSC3.4
RGSC_v3.4168,909,480 - 8,909,694UniSTSRGSC3.4
RGSC_v3.1168,909,478 - 8,909,692RGD
Celera166,579,508 - 6,579,722UniSTS
RH 3.4 Map1684.5UniSTS
RH 3.4 Map1684.5RGD
SHRSP x BN Map163.4UniSTS
SHRSP x BN Map163.4RGD
Cytogenetic Map16p16UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1 5 2
Low 3 43 47 31 19 31 8 11 74 34 36 9 8
Below cutoff 10 10 10

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001107297 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006252749 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006252750 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006252751 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017600084 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017600085 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017600086 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039094464 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039094467 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039094469 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063275358 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063275359 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063275360 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063275361 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide CH474046 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000016 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSRNOT00000035915   ⟹   ENSRNOP00000033034
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl168,581,784 - 8,631,547 (+)Ensembl
Rnor_6.0 Ensembl169,563,218 - 9,613,503 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000082208   ⟹   ENSRNOP00000068839
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl168,506,247 - 8,631,548 (+)Ensembl
Rnor_6.0 Ensembl169,486,832 - 9,613,528 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000101853   ⟹   ENSRNOP00000096403
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl168,476,306 - 8,631,548 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000104962   ⟹   ENSRNOP00000078254
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl168,528,948 - 8,631,548 (+)Ensembl
RefSeq Acc Id: NM_001107297   ⟹   NP_001100767
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8168,588,024 - 8,637,822 (+)NCBI
mRatBN7.2168,581,784 - 8,631,547 (+)NCBI
Rnor_6.0169,563,218 - 9,613,503 (+)NCBI
Rnor_5.01611,414,640 - 11,572,157 (+)NCBI
RGSC_v3.4168,863,537 - 8,913,459 (+)RGD
Celera166,575,743 - 6,625,300 (-)RGD
Sequence:
RefSeq Acc Id: XM_006252751   ⟹   XP_006252813
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8168,619,350 - 8,637,823 (+)NCBI
mRatBN7.2168,613,123 - 8,631,552 (+)NCBI
Rnor_6.0169,594,300 - 9,613,508 (+)NCBI
Rnor_5.01611,414,640 - 11,572,157 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017600084   ⟹   XP_017455573
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8168,482,722 - 8,637,823 (+)NCBI
mRatBN7.2168,476,445 - 8,631,552 (+)NCBI
Rnor_6.0169,454,269 - 9,613,508 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039094464   ⟹   XP_038950392
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8168,482,458 - 8,637,823 (+)NCBI
mRatBN7.2168,476,179 - 8,631,200 (+)NCBI
RefSeq Acc Id: XM_039094467   ⟹   XP_038950395
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8168,512,394 - 8,637,823 (+)NCBI
mRatBN7.2168,504,998 - 8,631,548 (+)NCBI
RefSeq Acc Id: XM_039094469   ⟹   XP_038950397
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8168,619,194 - 8,637,823 (+)NCBI
mRatBN7.2168,612,955 - 8,631,552 (+)NCBI
RefSeq Acc Id: XM_063275358   ⟹   XP_063131428
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8168,480,222 - 8,637,823 (+)NCBI
RefSeq Acc Id: XM_063275359   ⟹   XP_063131429
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8168,512,398 - 8,637,823 (+)NCBI
RefSeq Acc Id: XM_063275360   ⟹   XP_063131430
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8168,482,722 - 8,634,022 (+)NCBI
RefSeq Acc Id: XM_063275361   ⟹   XP_063131431
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8168,604,757 - 8,637,823 (+)NCBI
RefSeq Acc Id: NP_001100767   ⟸   NM_001107297
- UniProtKB: D4ABZ7 (UniProtKB/TrEMBL),   A6KFU6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006252813   ⟸   XM_006252751
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_017455573   ⟸   XM_017600084
- Peptide Label: isoform X3
- UniProtKB: A0A8I5ZKJ1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000033034   ⟸   ENSRNOT00000035915
RefSeq Acc Id: ENSRNOP00000068839   ⟸   ENSRNOT00000082208
RefSeq Acc Id: XP_038950392   ⟸   XM_039094464
- Peptide Label: isoform X1
- UniProtKB: A0A8I6APD0 (UniProtKB/TrEMBL),   A0A8I5ZKJ1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038950395   ⟸   XM_039094467
- Peptide Label: isoform X2
- UniProtKB: A0A8I5ZKJ1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038950397   ⟸   XM_039094469
- Peptide Label: isoform X6
RefSeq Acc Id: ENSRNOP00000096403   ⟸   ENSRNOT00000101853
RefSeq Acc Id: ENSRNOP00000078254   ⟸   ENSRNOT00000104962
RefSeq Acc Id: XP_063131428   ⟸   XM_063275358
- Peptide Label: isoform X3
- UniProtKB: A0A8I5ZKJ1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063131430   ⟸   XM_063275360
- Peptide Label: isoform X7
RefSeq Acc Id: XP_063131429   ⟸   XM_063275359
- Peptide Label: isoform X4
- UniProtKB: A0A8I5ZKJ1 (UniProtKB/TrEMBL),   A0A0G2JTT7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063131431   ⟸   XM_063275361
- Peptide Label: isoform X8
- UniProtKB: A0A8I5ZKJ1 (UniProtKB/TrEMBL)
Protein Domains
PH   Rho-GAP

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2JTT7-F1-model_v2 AlphaFold A0A0G2JTT7 1-700 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699959
Promoter ID:EPDNEW_R10472
Type:initiation region
Name:Arhgap22_1
Description:Rho GTPase activating protein 22
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R10473  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0169,486,804 - 9,486,864EPDNEW
RGD ID:13699949
Promoter ID:EPDNEW_R10473
Type:single initiation site
Name:Arhgap22_2
Description:Rho GTPase activating protein 22
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R10472  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0169,563,194 - 9,563,254EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307237 AgrOrtholog
BioCyc Gene G2FUF-12093 BioCyc
Ensembl Genes ENSRNOG00000024728 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000035915 ENTREZGENE
  ENSRNOT00000035915.3 UniProtKB/TrEMBL
  ENSRNOT00000082208.2 UniProtKB/TrEMBL
  ENSRNOT00000101853.1 UniProtKB/TrEMBL
  ENSRNOT00000104962.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.555.10 UniProtKB/TrEMBL
  2.30.29.30 UniProtKB/TrEMBL
InterPro PH_type UniProtKB/TrEMBL
  Pleckstrin_homology UniProtKB/TrEMBL
  Rho_GTPase_activation_prot UniProtKB/TrEMBL
  RhoGAP_dom UniProtKB/TrEMBL
KEGG Report rno:306279 UniProtKB/TrEMBL
NCBI Gene 306279 ENTREZGENE
PANTHER RHO GTPASE-ACTIVATING PROTEIN 22 UniProtKB/TrEMBL
  SPERMATHECAL PHYSIOLOGY VARIANT UniProtKB/TrEMBL
Pfam PF00169 UniProtKB/TrEMBL
  RhoGAP UniProtKB/TrEMBL
PhenoGen Arhgap22 PhenoGen
PROSITE PH_DOMAIN UniProtKB/TrEMBL
  RHOGAP UniProtKB/TrEMBL
RatGTEx ENSRNOG00000024728 RatGTEx
SMART RhoGAP UniProtKB/TrEMBL
  SM00233 UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/TrEMBL
  Rho_GAP UniProtKB/TrEMBL
UniProt A0A0G2JTT7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZKJ1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6APD0 ENTREZGENE, UniProtKB/TrEMBL
  A6KFU6 ENTREZGENE, UniProtKB/TrEMBL
  D4ABZ7 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Arhgap22  Rho GTPase activating protein 22   Arhgap22_predicted  Rho GTPase activating protein 22 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Arhgap22_predicted  Rho GTPase activating protein 22 (predicted)      Symbol and Name status set to approved 70820 APPROVED