Adam34l (a disintegrin and metalloprotease domain 34-like) - Rat Genome Database

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Gene: Adam34l (a disintegrin and metalloprotease domain 34-like) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Adam34l
Name: a disintegrin and metalloprotease domain 34-like
RGD ID: 1307052
Description: Predicted to enable metalloendopeptidase activity. Predicted to be involved in male gonad development and proteolysis. Predicted to be located in membrane. Predicted to be active in external side of plasma membrane and sperm head plasma membrane; INTERACTS WITH 6-propyl-2-thiouracil; amitrole; methimazole.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: a disintegrin and metalloprotease domain 34; Adam34; disintegrin and metalloproteinase domain-containing protein 26A; LOC364599
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81655,269,522 - 55,274,688 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1655,269,525 - 55,274,512 (+)EnsemblGRCr8
mRatBN7.21648,536,456 - 48,542,246 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1648,537,083 - 48,542,351 (+)EnsemblmRatBN7.2
Rnor_6.01651,728,003 - 51,733,028 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1651,730,452 - 51,733,226 (+)Ensemblrn6Rnor6.0
Rnor_5.01651,449,537 - 51,454,394 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41651,896,138 - 51,902,106 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1646,513,872 - 46,518,897 (+)NCBICelera
RGSC_v3.11651,876,587 - 51,898,591 (-)NCBI
Cytogenetic Map16q11NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline

Genomics

Variants

.
Variants in Adam34l
28 total Variants

QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2300163Bmd64Bone mineral density QTL 645.30.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)164445512389455123Rat
70215Niddm29Non-insulin dependent diabetes mellitus QTL 293.54blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)163692878281928782Rat
1578768Stresp22Stress response QTL 222.8thymus mass (VT:0004954)thymus wet weight (CMO:0000855)164199206486992064Rat
737826Alc11Alcohol consumption QTL 113.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16423421266955197Rat
2302057Pia29Pristane induced arthritis QTL 293.60.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)162846870173468701Rat
7205510Activ5Activity QTL 53.780.00028locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)164909919691442908Rat
1357403Slep4Serum leptin concentration QTL 43.91blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)163236104377361043Rat
631833Sach2Saccharin preference QTL 240.01consumption behavior trait (VT:0002069)calculated saccharin drink intake rate (CMO:0001613)164975766656898388Rat
8694453Bw172Body weight QTL 1728.330.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)163105803976058039Rat
1298529Arunc1Aerobic running capacity QTL 14exercise endurance trait (VT:0002332)longest distance run on treadmill (CMO:0001406)163439829479398294Rat
2312663Slep9Serum leptin concentration QTL 90.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1683908666195506Rat
2312660Bw95Body weight QTL 950.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)1683908666195506Rat
6903294Stl30Serum triglyceride level QTL 302.60.0013blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)163188527176885271Rat
2293690Bss45Bone structure and strength QTL 455.130.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)164445512389455123Rat
2312666Insul16Insulin level QTL 160.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1683908666195506Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161773081872536785Rat
2301406Kidm39Kidney mass QTL 390.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)161590580260905802Rat
2312669Stl23Serum triglyceride level QTL 230.01blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1683908666195506Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
1 2 7 4 4 3 2 3 11 2 7 3 21 1

Sequence


Ensembl Acc Id: ENSRNOT00000078614   ⟹   ENSRNOP00000073725
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1655,269,525 - 55,274,512 (+)Ensembl
mRatBN7.2 Ensembl1648,537,083 - 48,542,351 (+)Ensembl
Rnor_6.0 Ensembl1651,730,452 - 51,733,226 (+)Ensembl
RefSeq Acc Id: XM_006253179   ⟹   XP_006253241
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81655,269,522 - 55,274,688 (+)NCBI
mRatBN7.21648,536,456 - 48,542,246 (+)NCBI
Rnor_6.01651,728,003 - 51,733,028 (+)NCBI
Rnor_5.01651,449,537 - 51,454,394 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001419773 (Get FASTA)   NCBI Sequence Viewer  
  XP_006253241 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000073725
  ENSRNOP00000073725.1
RefSeq Acc Id: XP_006253241   ⟸   XM_006253179
- Sequence:
Ensembl Acc Id: ENSRNOP00000073725   ⟸   ENSRNOT00000078614
Protein Domains
Disintegrin   Peptidase M12B

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2K693-F1-model_v2 AlphaFold A0A0G2K693 1-792 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307052 AgrOrtholog
BioCyc Gene G2FUF-11298 BioCyc
Ensembl Genes ENSRNOG00000056277 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000078614 ENTREZGENE
  ENSRNOT00000078614.3 UniProtKB/TrEMBL
Gene3D-CATH 3.40.390.10 UniProtKB/TrEMBL
  4.10.70.10 UniProtKB/TrEMBL
InterPro ADAM_Cys-rich UniProtKB/TrEMBL
  Disintegrin_dom UniProtKB/TrEMBL
  Disintegrin_dom_sf UniProtKB/TrEMBL
  EGF-like_dom UniProtKB/TrEMBL
  MetalloPept_cat_dom UniProtKB/TrEMBL
  Peptidase_M12B UniProtKB/TrEMBL
  Peptidase_M12B_N UniProtKB/TrEMBL
  Reprolysin_adamalysin UniProtKB/TrEMBL
KEGG Report rno:364599 UniProtKB/TrEMBL
NCBI Gene 364599 ENTREZGENE
PANTHER A DISINTEGRIN AND METALLOPEPTIDASE DOMAIN 26B-RELATED UniProtKB/TrEMBL
  ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN UniProtKB/TrEMBL
Pfam ADAM_CR UniProtKB/TrEMBL
  Disintegrin UniProtKB/TrEMBL
  Pep_M12B_propep UniProtKB/TrEMBL
  Reprolysin UniProtKB/TrEMBL
PhenoGen Adam34l PhenoGen
PROSITE ADAM_MEPRO UniProtKB/TrEMBL
  DISINTEGRIN_2 UniProtKB/TrEMBL
  EGF_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000056277 RatGTEx
SMART ACR UniProtKB/TrEMBL
  DISIN UniProtKB/TrEMBL
Superfamily-SCOP Metalloproteases ('zincins'), catalytic domain UniProtKB/TrEMBL
  SSF57552 UniProtKB/TrEMBL
UniProt A0A0G2K693 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Adam34l  a disintegrin and metalloprotease domain 34-like  Adam34_predicted  a disintegrin and metalloprotease domain 34 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-12 Adam34_predicted  a disintegrin and metalloprotease domain 34 (predicted)      Symbol and Name status set to approved 70820 APPROVED