1,2-dimethylhydrazine decreases expression ISO RGD:1316001 6480464 1, 2-Dimethylhydrazine results in decreased expression of MAP2K4 mRNA CTD PMID:22206623 17beta-estradiol increases expression ISO RGD:1316000 6480464 Estradiol results in increased expression of MAP2K4 mRNA CTD PMID:23094148 17beta-estradiol multiple interactions ISO RGD:1316000 6480464 IGF1R mutant form inhibits the reaction [Estradiol results in increased expression of MAP2K4 mRNA] CTD PMID:23094148 17beta-hydroxy-5alpha-androstan-3-one increases expression ISO RGD:1316000 6480464 Dihydrotestosterone results in increased expression of MAP2K4 mRNA CTD PMID:29581250 2,2',4,4'-Tetrabromodiphenyl ether decreases expression ISO RGD:1316000 6480464 2 more ... CTD PMID:31675489 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:1316001 6480464 Tetrachlorodibenzodioxin affects the expression of MAP2K4 mRNA CTD PMID:21570461 2,3,7,8-tetrachlorodibenzodioxine decreases expression EXP 6480464 Tetrachlorodibenzodioxin results in decreased expression of MAP2K4 mRNA CTD PMID:32109520 2,4,6-tribromophenol decreases expression ISO RGD:1316000 6480464 2 more ... CTD PMID:31675489 3,3',5,5'-tetrabromobisphenol A decreases expression ISO RGD:1316000 6480464 tetrabromobisphenol A results in decreased expression of MAP2K4 protein CTD PMID:31675489 4,4'-sulfonyldiphenol multiple interactions ISO RGD:1316000 6480464 [bis(4-hydroxyphenyl)sulfone co-treated with Fulvestrant] results in increased methylation of MAP2K4 gene CTD PMID:31601247 4-hydroxyphenyl retinamide multiple interactions ISO RGD:1316000 6480464 Butylated Hydroxyanisole inhibits the reaction [Fenretinide results in increased phosphorylation of MAP2K4 protein] CTD PMID:16407847 4-hydroxyphenyl retinamide increases phosphorylation ISO RGD:1316000 6480464 Fenretinide results in increased phosphorylation of MAP2K4 protein CTD PMID:16407847 6-propyl-2-thiouracil decreases expression EXP 6480464 Propylthiouracil results in decreased expression of MAP2K4 mRNA CTD PMID:24780913 acetamide decreases expression EXP 6480464 acetamide results in decreased expression of MAP2K4 mRNA CTD PMID:31881176 Aciculatin multiple interactions ISO RGD:1316001 6480464 aciculatin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAP2K4 protein] CTD PMID:21548916 acrylamide increases expression ISO RGD:1316000 6480464 Acrylamide results in increased expression of MAP2K4 mRNA CTD PMID:32763439 actinomycin D decreases expression ISO RGD:1316000 6480464 Dactinomycin results in decreased expression of MAP2K4 mRNA CTD PMID:16001973 afimoxifene decreases response to substance ISO RGD:1316000 6480464 MAP2K4 results in decreased susceptibility to afimoxifene CTD PMID:21233418 aflatoxin B1 decreases methylation ISO RGD:1316000 6480464 Aflatoxin B1 results in decreased methylation of MAP2K4 gene CTD PMID:27153756 aflatoxin B1 increases expression ISO RGD:1316000 6480464 Aflatoxin B1 results in increased expression of MAP2K4 mRNA CTD PMID:27153756 alpha-mangostin increases phosphorylation ISO RGD:1316000 6480464 mangostin analog results in increased phosphorylation of MAP2K4 protein CTD PMID:28722351 alvocidib multiple interactions ISO RGD:1316000 6480464 alvocidib promotes the reaction [Bortezomib results in increased phosphorylation of and results in increased activity of MAP2K4 protein] CTD PMID:15039284 andrographolide multiple interactions ISO RGD:1316000 6480464 andrographolide inhibits the reaction [VEGFA protein results in increased phosphorylation of MAP2K4 protein] CTD PMID:24814888 Antimony trioxide multiple interactions ISO RGD:1316001 6480464 MAP2K4 protein affects the reaction [antimony trioxide results in increased activity of MAPK8 protein] CTD PMID:16112521 antimycin A decreases expression ISO RGD:1316000 6480464 Antimycin A results in decreased expression of MAP2K4 mRNA CTD PMID:33512557 antirheumatic drug increases expression ISO RGD:1316000 6480464 Antirheumatic Agents results in increased expression of MAP2K4 mRNA CTD PMID:24449571 aristolochic acid A decreases expression ISO RGD:1316000 6480464 aristolochic acid I results in decreased expression of MAP2K4 mRNA CTD PMID:33212167 arsenite(3-) multiple interactions ISO RGD:1316000 6480464 arsenite inhibits the reaction [G3BP1 protein binds to MAP2K4 mRNA] CTD PMID:32406909 arsenous acid multiple interactions ISO RGD:1316000 6480464 MAP2K4 gene mutant form inhibits the reaction [Arsenic Trioxide results in increased activity of MAPK8 protein] more ... CTD PMID:14701702 , PMID:15978632 arsenous acid increases response to substance ISO RGD:1316001 6480464 MAP2K4 protein results in increased susceptibility to Arsenic Trioxide CTD PMID:16184197 arsenous acid increases response to substance ISO RGD:1316000 6480464 MAP2K4 protein results in increased susceptibility to Arsenic Trioxide, MAP2K4 results in increased susceptibility to Arsenic Trioxide CTD PMID:14701702 , PMID:18633430 auramine O increases expression ISO RGD:1316000 6480464 Benzophenoneidum results in increased expression of MAP2K4 protein CTD PMID:28722353 benzo[a]pyrene increases phosphorylation ISO RGD:1316000 6480464 Benzo(a)pyrene analog results in increased phosphorylation of MAP2K4 protein CTD PMID:24910982 benzo[a]pyrene increases methylation ISO RGD:1316000 6480464 Benzo(a)pyrene results in increased methylation of MAP2K4 promoter CTD PMID:27901495 benzo[a]pyrene diol epoxide I decreases expression ISO RGD:1316000 6480464 7 more ... CTD PMID:19150397 benzo[a]pyrene diol epoxide I increases expression ISO RGD:1316000 6480464 7 more ... CTD PMID:26238291 benzo[a]pyrene diol epoxide I multiple interactions ISO RGD:1316001 6480464 AG 1879 inhibits the reaction [7 more ... CTD PMID:21501596 benzo[a]pyrene diol epoxide I increases phosphorylation ISO RGD:1316001 6480464 7 more ... CTD PMID:21501596 bis(2-chloroethyl) sulfide increases phosphorylation ISO RGD:1316001 6480464 Mustard Gas results in increased phosphorylation of MAP2K4 protein CTD PMID:18200059 bisphenol A affects expression EXP 6480464 bisphenol A affects the expression of MAP2K4 mRNA CTD PMID:25181051 bisphenol A increases methylation ISO RGD:1316000 6480464 bisphenol A results in increased methylation of MAP2K4 gene CTD PMID:31601247 bisphenol A decreases expression ISO RGD:1316000 6480464 bisphenol A results in decreased expression of MAP2K4 protein CTD PMID:31675489 bortezomib multiple interactions ISO RGD:1316000 6480464 alvocidib promotes the reaction [Bortezomib results in increased phosphorylation of and results in increased activity of MAP2K4 protein], Bortezomib results in increased phosphorylation of and results in increased activity of MAP2K4 protein CTD PMID:15039284 butylated hydroxyanisole multiple interactions ISO RGD:1316000 6480464 Butylated Hydroxyanisole inhibits the reaction [Fenretinide results in increased phosphorylation of MAP2K4 protein] CTD PMID:16407847 cadmium dichloride multiple interactions ISO RGD:1316000 6480464 Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAP2K4 protein] CTD PMID:18703135 cadmium dichloride increases phosphorylation EXP 6480464 Cadmium Chloride results in increased phosphorylation of MAP2K4 protein CTD PMID:18021293 , PMID:18703135 cadmium dichloride multiple interactions EXP 6480464 Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAP2K4 protein] CTD PMID:18703135 cadmium dichloride multiple interactions ISO RGD:1316001 6480464 [MAP2K4 co-treated with MAP2K7] affects the reaction [Cadmium Chloride results in increased expression of HSPA1A protein] more ... CTD PMID:18348256 cadmium dichloride increases phosphorylation ISO RGD:1316000 6480464 Cadmium Chloride results in increased phosphorylation of MAP2K4 protein CTD PMID:18703135 caffeine increases phosphorylation ISO RGD:1316000 6480464 Caffeine results in increased phosphorylation of MAP2K4 protein CTD PMID:35688186 celecoxib multiple interactions ISO RGD:1316001 6480464 Celecoxib inhibits the reaction [deoxynivalenol results in increased phosphorylation of MAP2K4 protein] CTD PMID:32416088 chlorogenic acid multiple interactions ISO RGD:1316001 6480464 Chlorogenic Acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAP2K4 protein] CTD PMID:15944151 chromium(6+) multiple interactions ISO RGD:1316001 6480464 MAP2K4 protein promotes the reaction [chromium hexavalent ion results in increased phosphorylation of ATF2 protein] more ... CTD PMID:19654923 chromium(6+) increases response to substance ISO RGD:1316001 6480464 MAP2K4 protein results in increased susceptibility to chromium hexavalent ion CTD PMID:19654923 cisplatin multiple interactions ISO RGD:1316000 6480464 [Cisplatin co-treated with Quercetin] results in increased expression of MAP2K4 mRNA CTD PMID:27514524 cobalt dichloride increases expression ISO RGD:1316000 6480464 cobaltous chloride results in increased expression of MAP2K4 mRNA CTD PMID:19376846 cocaine increases expression ISO RGD:1316001 6480464 Cocaine results in increased expression of MAP2K4 mRNA CTD PMID:18355967 copper atom multiple interactions EXP 6480464 [Copper co-treated with pyrrolidine dithiocarbamic acid] results in increased phosphorylation of MAP2K4 protein, Acetylcysteine inhibits the reaction [[Copper co-treated with pyrrolidine dithiocarbamic acid] results in increased phosphorylation of MAP2K4 protein] CTD PMID:22085843 copper atom multiple interactions ISO RGD:1316000 6480464 [Chelating Agents binds to Copper] which results in increased expression of MAP2K4 mRNA CTD PMID:30911355 copper(0) multiple interactions EXP 6480464 [Copper co-treated with pyrrolidine dithiocarbamic acid] results in increased phosphorylation of MAP2K4 protein, Acetylcysteine inhibits the reaction [[Copper co-treated with pyrrolidine dithiocarbamic acid] results in increased phosphorylation of MAP2K4 protein] CTD PMID:22085843 copper(0) multiple interactions ISO RGD:1316000 6480464 [Chelating Agents binds to Copper] which results in increased expression of MAP2K4 mRNA CTD PMID:30911355 crocidolite asbestos decreases phosphorylation ISO RGD:1316000 6480464 Asbestos, Crocidolite results in decreased phosphorylation of MAP2K4 protein CTD PMID:17191120 curcumin decreases expression ISO RGD:1316000 6480464 Curcumin results in decreased expression of MAP2K4 mRNA CTD PMID:15713895 curcumin increases phosphorylation ISO RGD:1316000 150429751 Curcumin increases phosphorylation of MAP2K4 protein in uterine cervix RGD cyclosporin A increases expression ISO RGD:1316001 6480464 Cyclosporine results in increased expression of MAP2K4 mRNA CTD PMID:19770486 cypermethrin multiple interactions ISO RGD:1316001 6480464 [[[cypermethrin results in decreased expression of MIR155 mRNA] which results in increased expression of BCL6 mRNA] which results in decreased expression of MAP2K4 protein] which results in decreased phosphorylation of and results in decreased activity of MAPK8 protein more ... CTD PMID:29471534 decabromodiphenyl ether decreases expression ISO RGD:1316000 6480464 decabromobiphenyl ether results in decreased expression of MAP2K4 protein CTD PMID:31675489 deoxynivalenol multiple interactions ISO RGD:1316001 6480464 Celecoxib inhibits the reaction [deoxynivalenol results in increased phosphorylation of MAP2K4 protein] CTD PMID:32416088 deoxynivalenol increases phosphorylation ISO RGD:1316001 6480464 deoxynivalenol results in increased phosphorylation of MAP2K4 protein CTD PMID:32416088 diallyl trisulfide multiple interactions ISO RGD:1316000 6480464 MAP2K4 protein affects the reaction [diallyl trisulfide results in increased abundance of Reactive Oxygen Species], MAP2K4 protein affects the reaction [diallyl trisulfide results in increased degradation of FTL protein] CTD PMID:16707465 diarsenic trioxide multiple interactions ISO RGD:1316000 6480464 MAP2K4 gene mutant form inhibits the reaction [Arsenic Trioxide results in increased activity of MAPK8 protein] more ... CTD PMID:14701702 , PMID:15978632 diarsenic trioxide increases response to substance ISO RGD:1316001 6480464 MAP2K4 protein results in increased susceptibility to Arsenic Trioxide CTD PMID:16184197 diarsenic trioxide increases response to substance ISO RGD:1316000 6480464 MAP2K4 protein results in increased susceptibility to Arsenic Trioxide, MAP2K4 results in increased susceptibility to Arsenic Trioxide CTD PMID:14701702 , PMID:18633430 dicrotophos decreases expression ISO RGD:1316000 6480464 dicrotophos results in decreased expression of MAP2K4 mRNA CTD PMID:28302478 disodium selenite multiple interactions ISO RGD:1316001 6480464 Sodium Selenite promotes the reaction [[Streptozocin co-treated with Dietary Fats] results in increased phosphorylation of MAP2K4 protein] CTD PMID:26522834 doxorubicin affects activity ISO RGD:1316000 6480464 Doxorubicin affects the activity of MAP2K4 protein CTD PMID:15870702 doxorubicin decreases response to substance ISO RGD:1316000 6480464 MAP2K4 protein results in decreased susceptibility to Doxorubicin CTD PMID:14701702 doxorubicin increases expression ISO RGD:1316000 6480464 Doxorubicin results in increased expression of MAP2K4 mRNA CTD PMID:16001973 endosulfan decreases expression ISO RGD:1316000 6480464 Endosulfan results in decreased expression of MAP2K4 mRNA CTD PMID:28108160 ethanol affects splicing ISO RGD:1316001 6480464 Ethanol affects the splicing of MAP2K4 mRNA CTD PMID:30319688 folic acid decreases expression ISO RGD:1316001 6480464 Folic Acid results in decreased expression of MAP2K4 mRNA CTD PMID:25629700 fulvestrant multiple interactions ISO RGD:1316000 6480464 [bis(4-hydroxyphenyl)sulfone co-treated with Fulvestrant] results in increased methylation of MAP2K4 gene CTD PMID:31601247 gallic acid increases expression ISO RGD:1316000 6480464 Gallic Acid results in increased expression of MAP2K4 mRNA CTD PMID:34408198 gingerol multiple interactions ISO RGD:1316001 6480464 gingerol inhibits the reaction [TNF protein results in increased phosphorylation of MAP2K4 protein] CTD PMID:18577375 glyphosate decreases expression ISO RGD:1316000 6480464 glyphosate results in decreased expression of MAP2K4 mRNA CTD PMID:31295307 glyphosate affects methylation ISO RGD:1316000 6480464 glyphosate affects the methylation of MAP2K4 gene CTD PMID:35377194 hydrogen cyanide decreases expression ISO RGD:1316001 6480464 Hydrogen Cyanide results in decreased expression of MKK4 mRNA CTD PMID:33914522 hydrogen peroxide multiple interactions ISO RGD:1316000 6480464 MAP2K4 protein affects the reaction [Hydrogen Peroxide results in increased degradation of FTL protein] CTD PMID:16707465 indometacin increases expression ISO RGD:1316000 6480464 Indomethacin results in increased expression of MAP2K4 protein CTD PMID:15804060 isoprenaline multiple interactions EXP 6480464 [Isoproterenol co-treated with POSTN protein] results in decreased expression of MAP2K4 mRNA CTD PMID:30303030 ivermectin decreases expression ISO RGD:1316000 6480464 Ivermectin results in decreased expression of MAP2K4 protein CTD PMID:32959892 Licochalcone A decreases phosphorylation ISO RGD:1316000 6480464 licochalcone A results in decreased phosphorylation of MAP2K4 protein CTD PMID:30187994 Licochalcone A multiple interactions ISO RGD:1316000 6480464 licochalcone A promotes the reaction [Sorafenib results in decreased phosphorylation of MAP2K4 protein], Sorafenib promotes the reaction [licochalcone A results in decreased phosphorylation of MAP2K4 protein] CTD PMID:30187994 lipopolysaccharide increases phosphorylation ISO RGD:1316000 150429951 lipopolysaccharide increases phosphorylation of MAP2K4 protein in the pulmonary alveolus epithelium RGD lipopolysaccharide increases phosphorylation ISO RGD:1316001 6480464 Lipopolysaccharides results in increased phosphorylation of MAP2K4 protein CTD PMID:21548916 lipopolysaccharide increases activity ISO RGD:1316001 6480464 Lipopolysaccharides results in increased activity of MAP2K4 protein CTD PMID:20589745 lipopolysaccharide multiple interactions ISO RGD:1316001 6480464 [Manganese co-treated with Lipopolysaccharides] results in increased activity of and results in increased phosphorylation of MAP2K4 protein more ... CTD PMID:20589745 , PMID:21548916 lipopolysaccharide multiple interactions ISO RGD:1316000 6480464 MYD88 protein promotes the reaction [Lipopolysaccharides results in increased phosphorylation of MAP2K4 protein], TLR2 protein promotes the reaction [Lipopolysaccharides results in increased phosphorylation of MAP2K4 protein] CTD PMID:21112663 lipopolysaccharide increases phosphorylation ISO RGD:1316000 6480464 Lipopolysaccharides results in increased phosphorylation of MAP2K4 protein CTD PMID:21112663 lycopene decreases expression ISO RGD:1316000 6480464 lycopene results in decreased expression of MAP2K4 protein CTD PMID:17337101 maneb multiple interactions ISO RGD:1316001 6480464 [Maneb co-treated with Paraquat] results in decreased expression of MAP2K4 mRNA CTD PMID:36117858 manganese atom multiple interactions ISO RGD:1316001 6480464 [Manganese co-treated with Lipopolysaccharides] results in increased activity of and results in increased phosphorylation of MAP2K4 protein more ... CTD PMID:20589745 manganese atom decreases phosphorylation ISO RGD:1316001 6480464 Manganese results in decreased phosphorylation of MAP2K4 protein CTD PMID:20589745 manganese(0) multiple interactions ISO RGD:1316001 6480464 [Manganese co-treated with Lipopolysaccharides] results in increased activity of and results in increased phosphorylation of MAP2K4 protein more ... CTD PMID:20589745 manganese(0) decreases phosphorylation ISO RGD:1316001 6480464 Manganese results in decreased phosphorylation of MAP2K4 protein CTD PMID:20589745 manganese(II) chloride increases phosphorylation EXP 6480464 manganese chloride results in increased phosphorylation of MAP2K4 protein CTD PMID:15342272 , PMID:9751194 methidathion affects expression ISO RGD:1316001 6480464 methidathion affects the expression of MAP2K4 mRNA CTD PMID:34813904 methotrexate increases expression ISO RGD:1316000 6480464 Methotrexate results in increased expression of MAP2K4 mRNA CTD PMID:21678067 mevinphos increases phosphorylation EXP 6480464 Mevinphos results in increased phosphorylation of MAP2K4 protein CTD PMID:23157661 monosodium L-glutamate decreases expression EXP 6480464 Sodium Glutamate results in decreased expression of MAP2K4 mRNA CTD PMID:28954212 N-acetyl-L-cysteine multiple interactions ISO RGD:1316000 6480464 Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAP2K4 protein] CTD PMID:18703135 N-acetyl-L-cysteine multiple interactions ISO RGD:1316000 150429751 N-acetyl-L-cysteine inhibits the reaction [Curcumin increases phosphorylation of MAP2K4 protein in uterine cervix] RGD N-acetyl-L-cysteine multiple interactions EXP 6480464 Acetylcysteine inhibits the reaction [[Copper co-treated with pyrrolidine dithiocarbamic acid] results in increased phosphorylation of MAP2K4 protein], Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAP2K4 protein] CTD PMID:18703135 , PMID:22085843 N-nitrosodiethylamine multiple interactions ISO RGD:1316001 6480464 Diethylnitrosamine results in increased phosphorylation of and results in increased activity of MAP2K4 protein, MAPK14 protein inhibits the reaction [Diethylnitrosamine results in increased phosphorylation of and results in increased activity of MAP2K4 protein] CTD PMID:18691550 N-nitrosodimethylamine multiple interactions EXP 6480464 [GJB1 protein affects the susceptibility to [Dietary Fats co-treated with Dimethylnitrosamine]] which affects the phosphorylation of MAP2K4 protein CTD PMID:32833043 nickel dichloride multiple interactions ISO RGD:1316001 6480464 GADD45A protein inhibits the reaction [nickel chloride results in increased activity of MAP2K4 protein] CTD PMID:23536762 p-menthan-3-ol increases expression ISO RGD:1316000 6480464 Menthol results in increased expression of MAP2K4 mRNA CTD PMID:26760959 paclitaxel multiple interactions ISO RGD:1316000 6480464 MAP2K4 protein affects the reaction [Paclitaxel results in increased activity of CASP3 protein], MAP2K4 protein affects the reaction [Paclitaxel results in increased cleavage of PARP1 protein] CTD PMID:10075725 paracetamol affects expression ISO RGD:1316001 6480464 Acetaminophen affects the expression of MAP2K4 mRNA CTD PMID:17562736 paracetamol increases expression EXP 6480464 Acetaminophen results in increased expression of MAP2K4 mRNA CTD PMID:33387578 paracetamol multiple interactions ISO RGD:1316001 6480464 [RIPK1 protein affects the susceptibility to Acetaminophen] which affects the phosphorylation of MAP2K4 protein more ... CTD PMID:22687999 more ... paracetamol increases phosphorylation ISO RGD:1316001 6480464 Acetaminophen results in increased phosphorylation of MAP2K4 protein CTD PMID:22687999 more ... paracetamol increases response to substance EXP 6480464 MAP2K4 results in increased susceptibility to Acetaminophen CTD PMID:11562448 paracetamol multiple interactions EXP 6480464 Acetaminophen results in increased phosphorylation of and results in increased activity of MAP2K4 protein, MAP2K4 mutant form inhibits the reaction [Acetaminophen results in increased activity of MAPK8 protein] CTD PMID:11562448 paraquat multiple interactions ISO RGD:1316001 6480464 [Maneb co-treated with Paraquat] results in decreased expression of MAP2K4 mRNA CTD PMID:36117858 perfluorooctane-1-sulfonic acid decreases expression ISO RGD:1316001 6480464 perfluorooctane sulfonic acid results in decreased expression of MAP2K4 protein CTD PMID:26178269 phorbol 13-acetate 12-myristate multiple interactions ISO RGD:1316001 6480464 Chlorogenic Acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAP2K4 protein] CTD PMID:15944151 picoxystrobin decreases expression ISO RGD:1316000 6480464 picoxystrobin results in decreased expression of MAP2K4 mRNA CTD PMID:33512557 pyrrolidine dithiocarbamate multiple interactions EXP 6480464 [Copper co-treated with pyrrolidine dithiocarbamic acid] results in increased phosphorylation of MAP2K4 protein, Acetylcysteine inhibits the reaction [[Copper co-treated with pyrrolidine dithiocarbamic acid] results in increased phosphorylation of MAP2K4 protein] CTD PMID:22085843 quercetin increases expression ISO RGD:1316000 6480464 Quercetin results in increased expression of MAP2K4 mRNA CTD PMID:23727915 quercetin increases expression EXP 6480464 Quercetin results in increased expression of MAP2K4 mRNA CTD PMID:17103110 quercetin decreases expression ISO RGD:1316000 6480464 Quercetin results in decreased expression of MAP2K4 mRNA CTD PMID:15309432 quercetin multiple interactions ISO RGD:1316000 6480464 [Cisplatin co-treated with Quercetin] results in increased expression of MAP2K4 mRNA, Quercetin inhibits the reaction [[CYP2E1 protein results in increased susceptibility to Docosahexaenoic Acids] which results in increased phosphorylation of MAP2K4 protein] CTD PMID:16963249 , PMID:27514524 reactive oxygen species multiple interactions ISO RGD:1316000 6480464 MAP2K4 protein affects the reaction [diallyl trisulfide results in increased abundance of Reactive Oxygen Species] CTD PMID:16707465 scutellarin multiple interactions ISO RGD:1316001 6480464 scutellarin inhibits the reaction [Zearalenone results in increased expression of MAP2K4 protein] CTD PMID:36252740 sodium arsenite increases expression ISO RGD:1316000 6480464 sodium arsenite results in increased expression of MAP2K4 mRNA CTD PMID:12760830 sodium arsenite decreases expression ISO RGD:1316001 6480464 sodium arsenite results in decreased expression of MAP2K4 mRNA CTD PMID:31233874 sodium arsenite multiple interactions ISO RGD:1316000 6480464 MAP2K4 mutant form affects the reaction [sodium arsenite results in increased expression of TP53 protein], MAP2K4 mutant form inhibits the reaction [sodium arsenite results in increased expression of CDKN1A protein] CTD PMID:15734884 sodium arsenite multiple interactions ISO RGD:1316001 6480464 CDKN1B protein inhibits the reaction [sodium arsenite results in increased activity of MAP2K4 protein] CTD PMID:20566634 sorafenib multiple interactions ISO RGD:1316000 6480464 licochalcone A promotes the reaction [Sorafenib results in decreased phosphorylation of MAP2K4 protein], Sorafenib promotes the reaction [licochalcone A results in decreased phosphorylation of MAP2K4 protein] CTD PMID:30187994 sorafenib decreases phosphorylation ISO RGD:1316000 6480464 Sorafenib results in decreased phosphorylation of MAP2K4 protein CTD PMID:30187994 streptozocin multiple interactions ISO RGD:1316001 6480464 [Streptozocin co-treated with Dietary Fats] results in increased phosphorylation of MAP2K4 protein, Sodium Selenite promotes the reaction [[Streptozocin co-treated with Dietary Fats] results in increased phosphorylation of MAP2K4 protein] CTD PMID:26522834 sulforaphane increases expression ISO RGD:1316000 6480464 sulforaphane results in increased expression of MAP2K4 mRNA CTD PMID:31838189 sulindac sulfone multiple interactions ISO RGD:1316000 6480464 sulindac sulfone results in increased phosphorylation of and results in increased activity of MAP2K4 protein CTD PMID:11051267 tamoxifen increases expression ISO RGD:1316000 6480464 Tamoxifen results in increased expression of MAP2K4 mRNA CTD PMID:15590111 tebufenpyrad decreases expression ISO RGD:1316000 6480464 4-chloro-N-((4-(1, 1-dimethylethyl)phenyl)methyl)-3-ethyl-1-methyl-1H-pyrazole-5-carboxamide results in decreased expression of MAP2K4 mRNA CTD PMID:33512557 tert-butyl hydroperoxide increases phosphorylation ISO RGD:1316000 6480464 tert-Butylhydroperoxide results in increased phosphorylation of MAP2K4 protein CTD PMID:17003459 testosterone decreases expression ISO RGD:1316000 6480464 Testosterone results in decreased expression of MAP2K4 mRNA CTD PMID:33359661 thapsigargin decreases expression ISO RGD:1316001 6480464 Thapsigargin results in decreased expression of MAP2K4 protein CTD PMID:24648495 topotecan decreases expression EXP 6480464 Topotecan results in decreased expression of MAP2K4 mRNA CTD PMID:25729387 valproic acid decreases expression ISO RGD:1316000 6480464 Valproic Acid results in decreased expression of MAP2K4 mRNA CTD PMID:23179753 valproic acid affects expression ISO RGD:1316000 6480464 Valproic Acid affects the expression of MAP2K4 mRNA CTD PMID:25979313 vinclozolin increases expression EXP 6480464 vinclozolin results in increased expression of MAP2K4 mRNA CTD PMID:23555832 zearalenone decreases expression ISO RGD:1316001 6480464 Zearalenone results in decreased expression of MAP2K4 protein CTD PMID:36252740 zearalenone multiple interactions ISO RGD:1316001 6480464 scutellarin inhibits the reaction [Zearalenone results in increased expression of MAP2K4 protein] CTD PMID:36252740 zearalenone increases expression ISO RGD:1316001 6480464 Zearalenone results in increased expression of MAP2K4 protein CTD PMID:36252740 zinc dichloride increases activity ISO RGD:1316001 6480464 zinc chloride results in increased activity of MAP2K4 protein CTD PMID:11306679
