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Gene: Lamp5 (lysosomal-associated membrane protein family, member 5) Rattus norvegicus

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Symbol:

Lamp5

Name:

lysosomal-associated membrane protein family, member 5

RGD ID:

1306991

Description:

Predicted to be involved in establishment of protein localization to organelle and presynaptic modulation of chemical synaptic transmission. Predicted to be located in several cellular components, including endoplasmic reticulum-Golgi intermediate compartment membrane; endosome; and growth cone membrane. Predicted to be active in several cellular components, including GABA-ergic synapse; cytoplasmic vesicle; and lysosomal membrane. Orthologous to human LAMP5 (lysosomal associated membrane protein family member 5); INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

BAD-LAMP; brain and dendritic cell-associated LAMP; brain-associated LAMP-like protein; LAMP family protein C20orf103 homolog; LAMP-5; LOC362220; lysosome-associated membrane glycoprotein 5; lysosome-associated membrane protein 5; RGD1306991; similar to Protein C20orf103 precursor

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	143,825,197 - 143,837,699 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	3	143,819,281 - 143,837,678 (+)	Ensembl				GRCr8
mRatBN7.2	3	123,372,462 - 123,384,973 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	123,372,462 - 123,384,952 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	3	127,272,344 - 127,284,976 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	135,849,326 - 135,861,964 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	133,527,966 - 133,540,604 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	129,012,677 - 129,031,522 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	129,018,592 - 129,031,521 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	3	135,507,575 - 135,519,611 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	3	124,126,095 - 124,140,577 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	3	122,103,532 - 122,115,537 (+)	NCBI		Celera
RGSC_v3.1	3	124,031,667 - 124,046,150 (+)	NCBI
Cytogenetic Map	3	q36	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

congenital myasthenic syndrome 18 (ISO)

developmental and epileptic encephalopathy 12 (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

2,2',4,4'-Tetrabromodiphenyl ether (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP)

2,3,7,8-Tetrachlorodibenzofuran (EXP)

2,4-dibromophenyl 2,4,5-tribromophenyl ether (ISO)

6-propyl-2-thiouracil (EXP)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

arsenite(3-) (ISO)

arsenous acid (ISO)

atrazine (ISO)

benzo[a]pyrene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP)

chlorpyrifos (ISO)

diarsenic trioxide (ISO)

ethanol (ISO)

iron atom (ISO)

iron(0) (ISO)

isoflurane (ISO)

ketamine (EXP)

methylmercury chloride (ISO)

mono(2-ethylhexyl) phthalate (ISO)

perfluorooctanoic acid (ISO)

Soman (EXP)

sulforaphane (ISO)

testosterone (EXP)

thapsigargin (ISO)

triphenyl phosphate (ISO)

tunicamycin (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

establishment of protein localization to organelle (IBA)

presynaptic modulation of chemical synaptic transmission (IEA,ISO)

Cellular Component

cytoplasmic vesicle (IEA)

cytoplasmic vesicle membrane (IEA,ISO,ISS)

dendrite (IEA)

dendrite membrane (IEA,ISO,ISS)

early endosome membrane (IEA,ISO,ISS)

endoplasmic reticulum-Golgi intermediate compartment membrane (IEA,ISO,ISS)

endosome membrane (IEA,ISO,ISS)

GABA-ergic synapse (IEA,ISO)

growth cone membrane (IEA,ISO,ISS)

late endosome (IEA,ISO)

late endosome membrane (IBA)

lysosomal membrane (IBA)

lysosome (IEA,ISO)

membrane (IEA)

plasma membrane (IBA,IEA,ISO,ISS)

recycling endosome (IEA)

recycling endosome membrane (IEA,ISO,ISS)

synaptic vesicle (IEA,ISO)

synaptic vesicle membrane (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	GOA pipeline	RGD automated data pipeline
3.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
5.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.

Additional References at PubMed

PMID:17215451	PMID:21642595	PMID:25592972

Genomics

Comparative Map Data

Lamp5
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	143,825,197 - 143,837,699 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	3	143,819,281 - 143,837,678 (+)	Ensembl				GRCr8
mRatBN7.2	3	123,372,462 - 123,384,973 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	123,372,462 - 123,384,952 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	3	127,272,344 - 127,284,976 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	135,849,326 - 135,861,964 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	133,527,966 - 133,540,604 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	129,012,677 - 129,031,522 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	129,018,592 - 129,031,521 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	3	135,507,575 - 135,519,611 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	3	124,126,095 - 124,140,577 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	3	122,103,532 - 122,115,537 (+)	NCBI		Celera
RGSC_v3.1	3	124,031,667 - 124,046,150 (+)	NCBI
Cytogenetic Map	3	q36	NCBI

LAMP5
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	20	9,514,590 - 9,530,524 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	20	9,514,316 - 9,530,541 (+)	Ensembl			hg38	GRCh38
GRCh37	20	9,495,237 - 9,511,171 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	20	9,443,271 - 9,459,171 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	20	9,443,270 - 9,459,171	NCBI
Celera	20	9,565,283 - 9,581,196 (+)	NCBI		Celera
Cytogenetic Map	20	p12.2	NCBI
HuRef	20	9,446,942 - 9,463,136 (+)	NCBI		HuRef
CHM1_1	20	9,496,119 - 9,512,324 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	20	9,557,493 - 9,573,427 (+)	NCBI		T2T-CHM13v2.0

Lamp5
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	135,893,945 - 135,911,837 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	135,894,159 - 135,911,837 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	2	136,052,025 - 136,069,917 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	136,052,239 - 136,069,917 (+)	Ensembl			mm10	GRCm38
MGSCv37	2	135,883,663 - 135,895,653 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	2	135,749,368 - 135,761,358 (+)	NCBI		MGSCv36	mm8
Celera	2	137,256,215 - 137,268,204 (+)	NCBI		Celera
Cytogenetic Map	2	F3	NCBI
cM Map	2	67.26	NCBI

Lamp5
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955415	19,488,527 - 19,502,640 (+)	Ensembl
ChiLan1.0	NW_004955415	19,488,533 - 19,502,599 (+)	NCBI	ChiLan1.0	ChiLan1.0

LAMP5
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	21	10,413,731 - 10,429,484 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	20	10,410,210 - 10,426,311 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	20	9,487,971 - 9,503,912 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	20	9,489,969 - 9,506,137 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	20	9,489,849 - 9,506,137 (+)	Ensembl			panPan2	panpan1.1

LAMP5
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	24	12,678,209 - 12,693,847 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	24	12,678,837 - 12,694,284 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	24	12,503,699 - 12,519,030 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	24	13,091,592 - 13,106,970 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	24	13,090,626 - 13,112,707 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	24	12,697,277 - 12,712,659 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	24	12,796,787 - 12,812,122 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	24	13,140,965 - 13,156,359 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Lamp5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	161,521,587 - 161,525,562 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936485	9,952,159 - 9,957,016 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936485	9,952,975 - 9,964,358 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

LAMP5
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	17	18,434,658 - 18,452,927 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	17	18,434,106 - 18,452,689 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	17	20,802,370 - 20,820,480 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

LAMP5
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	2	28,602,479 - 28,619,632 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	2	28,601,497 - 28,624,572 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666071	15,950,356 - 15,967,723 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Lamp5
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624741	10,453,982 - 10,468,969 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624741	10,454,012 - 10,468,662 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Lamp5
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	5	115,692,151 - 115,704,331 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Lamp5
42 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	111
Count of miRNA genes:	86
Interacting mature miRNAs:	102
Transcripts:	ENSRNOT00000007274
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
12879876	Bw182	Body weight QTL 182		0.003	body mass (VT:0001259)	body weight (CMO:0000012)	3	141555229	186555229	Rat
2301411	Bp320	Blood pressure QTL 320		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	141555229	186555229	Rat
1582233	Insul10	Insulin level QTL 10	5.4	0.0015	blood insulin amount (VT:0001560)	serum insulin level times blood glucose level (CMO:0002040)	3	133259579	178259579	Rat
12879872	Cm97	Cardiac mass QTL 97		0.001	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	3	141555229	186555229	Rat
12879873	Cm96	Cardiac mass QTL 96		0.001	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	3	141555229	186555229	Rat
2302373	Gluco39	Glucose level QTL 39	5.01		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	3	129154923	182114333	Rat
12879874	Cm98	Cardiac mass QTL 98		0.005	heart right ventricle mass (VT:0007033)	heart right ventricle weight to body weight ratio (CMO:0000914)	3	141555229	186555229	Rat
12879875	Kidm64	Kidney mass QTL 64		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	3	141555229	186555229	Rat
70216	Cm14	Cardiac mass QTL 14	2.1		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	3	51581665	184004958	Rat
2292591	Esta4	Estrogen-induced thymic atrophy QTL 4			thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	3	67641776	167835660	Rat
1358362	Srcrt2	Stress Responsive Cort QTL 2	2.78		blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	3	58601291	153936591	Rat
7387306	Bw124	Body weight QTL 124	3.2	0.0003	body mass (VT:0001259)	body weight (CMO:0000012)	3	104545086	149545086	Rat
1578754	Stresp16	Stress response QTL 16	4	0.001	blood renin amount (VT:0003349)	plasma renin activity level (CMO:0000116)	3	133134628	178134628	Rat
1300173	Rf11	Renal function QTL 11	3.38		renal blood flow trait (VT:2000006)	absolute change in renal blood flow rate (CMO:0001168)	3	141508991	166376254	Rat
8694437	Bw167	Body weight QTL 167	22.46	0.001	retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	3	112250810	157250810	Rat
10755461	Coatc16	Coat color QTL 16			coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	3	142898802	187898802	Rat
8662816	Vetf4	Vascular elastic tissue fragility QTL 4	4		renal artery integrity trait (VT:0010642)	number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)	3	79649560	177741895	Rat
1354611	Despr2	Despair related QTL 2	3.03	0.0028	locomotor behavior trait (VT:0001392)	amount of time spent in voluntary immobility (CMO:0001043)	3	117537367	162537367	Rat
2303620	Vencon4	Ventilatory control QTL 4	3.9		respiration trait (VT:0001943)	tidal volume (CMO:0000222)	3	125116475	170116475	Rat
631649	Bp123	Blood pressure QTL 123	3.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	110225882	155225882	Rat
1358204	Insglur1	Insulin/glucose ratio QTL 1	3.8		blood glucose amount (VT:0000188)	serum glucose level (CMO:0000543)	3	136091420	155634702	Rat
1576306	Schws3	Schwannoma susceptibility QTL 3		0.001	nervous system integrity trait (VT:0010566)	percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)	3	139299381	184299381	Rat
5686842	Rf59	Renal function QTL 59			urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	3	122395989	167395989	Rat
1300159	Kidm4	Kidney mass QTL 4	3.83		kidney mass (VT:0002707)	right kidney wet weight to body weight ratio (CMO:0001953)	3	141508991	177728348	Rat
2301971	Cm71	Cardiac mass QTL 71	4.63		heart left ventricle mass (VT:0007031)	heart left ventricle weight (CMO:0000776)	3	131036586	176036586	Rat
631673	Iddm13	Insulin dependent diabetes mellitus QTL 13	1.3	0.663	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	3	137114333	182114333	Rat
2301970	Bw81	Body weight QTL 81	5.19		body mass (VT:0001259)	body weight (CMO:0000012)	3	131036586	176036586	Rat
1581546	Pur13	Proteinuria QTL 13	2.93	0.0335	urine total protein amount (VT:0000032)	urine protein excretion rate (CMO:0000759)	3	98651826	167012663	Rat
1331758	Bp207	Blood pressure QTL 207	2.848		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	110634702	155634702	Rat
12879871	Am7	Aortic mass QTL 7		0.001	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	3	141555229	186555229	Rat
724532	Cm17	Cardiac mass QTL 17	2		heart mass (VT:0007028)	calculated heart weight (CMO:0000073)	3	116188400	161188400	Rat

Markers in Region

RH128853

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	3	123,384,746 - 123,384,932 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	129,031,294 - 129,031,479	NCBI	Rnor6.0
Rnor_5.0	3	135,519,388 - 135,519,573	UniSTS	Rnor5.0
RGSC_v3.4	3	124,140,354 - 124,140,539	UniSTS	RGSC3.4
Celera	3	122,115,314 - 122,115,499	UniSTS
RH 3.4 Map	3	1077.7	UniSTS
Cytogenetic Map	3	q36	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
7	3	10	127	32	25	9	17	9	6	103	40	2	110	44	60	16	15	15

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001014183	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017591911	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC087680	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473949	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GM048034	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GM048065	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GM675600	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000003	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000007274 ⟹ ENSRNOP00000007274

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	3	143,819,281 - 143,837,678 (+)	Ensembl
mRatBN7.2 Ensembl	3	123,372,462 - 123,384,952 (+)	Ensembl
Rnor_6.0 Ensembl	3	129,018,592 - 129,031,521 (+)	Ensembl

RefSeq Acc Id:

NM_001014183 ⟹ NP_001014205

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	143,825,197 - 143,837,699 (+)	NCBI
mRatBN7.2	3	123,372,462 - 123,384,973 (+)	NCBI
Rnor_6.0	3	129,018,802 - 129,031,517 (+)	NCBI
Rnor_5.0	3	135,507,575 - 135,519,611 (+)	NCBI
RGSC_v3.4	3	124,126,095 - 124,140,577 (+)	RGD
Celera	3	122,103,532 - 122,115,537 (+)	RGD

Sequence:

show sequence

TTCCTCCCCCACACCACCCCAATCCTATTGGCCTTCTCCACAAGCCAAATTACAAATCCTGCAA
CACAACCTCGTTGTTTCCAGAACTCTCAGCGTGGACAGCTCCCGCATCCTGGGTGCCTCCTCTG
CAGTGTGCGGCAAGGGAGCTGTAGCGCCTGGTGAAGCACGAGACAATCCCGCGCGCTCGCTCCT
CCCTGTCCGCCCCCTCCCTTAGCTCACTCTACCGGCCACTTTGAGGGATTTCCTCCCGGGGCGG
CCTTTGCAGCAGAAACACATCTGCCTGGTTCCCGGCAACAGCATGGATCTACGAGGAAGAGCCC
TTCTCGGTGGAGACAGACTTCGGATTCTCCTAATGTTCTTCCATGCAATGGCCCAAACCGTGGC
AGAACAAGAAGTGGAAAATCTTTCGGGCCTTTCCACGAACCCGGAGAAAGACATATTTGTGGTG
CGGGAAAATGGGACGACGTGTCTCATGGCAGAGTTTGCAGCCAAATTTATTGTACCTTATGATG
TGTGGGCCAGCAATTATGTGGATCTGATCACAGAGCAGGCTGAGATCTCCTTGACCCGGGGAGC
TGAGGTGAAGGGCCGCTGTGGTCACAACGAGTCGGAGCTGCAGGTGTTCTGGGTAGATCGCGCC
TACACACTCAAAATGCTCTTTGTAAAGGAAAGTCACAACACTTCCAAAGGACTAGAGGCGACTT
GGAAGCTGAGCAAGGTGCAGTTTGTCTATGATTCCTCAGAGAAGACCCACTTTAAAGATGCTGT
GAGTGCTGGGAAGCATACCGCCAACTCTCACCACCTCTCTGCCTTGGTGACCCCAGCTGGGATG
TCCTATGAGTGCCAGGCTCAGCAGACCATTTCTCTGGCCTCCAGTGATCCTCAGAAGACTGTCA
CCATGATCCTGTCTGCAGTGCACATTCAGCCCTTTGATATCATCTCTGACTTTGTCTTCAGTGA
AGAGCATAAATGTCCAGTGGATGAGCGAGAACAGTTGGAAGAGACCCTGCCCCTGATCCTGGGC
CTCATCTTAGGCCTGGTCATTGTCATAACACTTGTGATTTACCACATTCATCACAAAATGACTG
CCAACCAAGTGCAGATCCCCAGAGACCGTTCCCAGTACAAGCACATGGGCTAGAGCCATCAGGC
AGACAGCCTCCACGTCCTGCCCCCAAACCGGATGACGTAGAGTGGCAATGACACTTTTTCACCT
GTATACAGGATCCACCAACATAGCTACACTCCAACAGGCCCAGGCACCTGAGGTCTGACTGGCC
TGTGTCCATGCTTAAACCCAGGGATGAAAGACAGGCCTTGGGGTTTGGGGGATTAATGGTGACT
GTTGTGTCCATGCTGGGCAGTAAGGGTGGGTGAGTAGGGTAACAGCTTTCGTGCTCATGATGGC
TTAACTTTGGCTCTCTGACTTTGTAAGTCTACAGCATGTAGAAGGGACGATATGGTCCTTATAT
TTAGAAAGTGGACCACTTCCTTTGGGAGACCTCTTTAGATCTAAAGACACCGGGTGCTTCAGTC
CCTTGGCCTCAGCTGGCATATTACACAGTTTTCAATGCACACAAAATACAACCTCATGCTCCTT
GCAAGCAGCAAGACCCCTGAAAGTGACCCATGCTTCTGGCTGGCACTCTGCATGTCTAGTGATT
GTTTTGGGAATGTTTCACTGCTACCTGCACCCAGTGACTCTGCAGCACAAGAACCCGTCTAATG
TCACTATGCACGGTTGTTTGGAATTCATAATGTGTCGGTTCCAAGTGAGGGGACCTCAAGAATT
TATGTGAGTTTGCTTTTGAAAATGAATTAAAAAGAAAAAAACAGCAAAAAAAAAAAAAAAAAAA
AAAAAAGG

hide sequence

Protein Sequences


Protein RefSeqs	NP_001014205	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH87680	(Get FASTA)	NCBI Sequence Viewer
	CAT03713	(Get FASTA)	NCBI Sequence Viewer
	CAT03725	(Get FASTA)	NCBI Sequence Viewer
	CAV33177	(Get FASTA)	NCBI Sequence Viewer
	EDL80298	(Get FASTA)	NCBI Sequence Viewer
	EDL80299	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000007274
	ENSRNOP00000007274.5
GenBank Protein	Q5PPI4	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_001014205 ⟸ NM_001014183
- Peptide Label:	precursor
- UniProtKB:	Q5PPI4 (UniProtKB/Swiss-Prot)
- Sequence:	show sequence MDLRGRALLGGDRLRILLMFFHAMAQTVAEQEVENLSGLSTNPEKDIFVVRENGTTCLMAEFAA KFIVPYDVWASNYVDLITEQAEISLTRGAEVKGRCGHNESELQVFWVDRAYTLKMLFVKESHNT SKGLEATWKLSKVQFVYDSSEKTHFKDAVSAGKHTANSHHLSALVTPAGMSYECQAQQTISLAS SDPQKTVTMILSAVHIQPFDIISDFVFSEEHKCPVDEREQLEETLPLILGLILGLVIVITLVIY HIHHKMTANQVQIPRDRSQYKHMG hide sequence

Ensembl Acc Id:

ENSRNOP00000007274 ⟸ ENSRNOT00000007274

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q5PPI4-F1-model_v2	AlphaFold	Q5PPI4	1-280	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1306991	AgrOrtholog
BioCyc Gene	G2FUF-47726	BioCyc
Ensembl Genes	ENSRNOG00000005457	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000007274	ENTREZGENE
	ENSRNOT00000007274.8	UniProtKB/Swiss-Prot
Gene3D-CATH	2.40.160.110	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:7318802	IMAGE-MGC_LOAD
InterPro	Lamp2-like_luminal	UniProtKB/Swiss-Prot
	Lysosome-assoc_membr_glycop	UniProtKB/Swiss-Prot
KEGG Report	rno:362220	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:105629	IMAGE-MGC_LOAD
NCBI Gene	362220	ENTREZGENE
PANTHER	LYSOSOME-ASSOCIATED MEMBRANE GLYCOPROTEIN 5	UniProtKB/Swiss-Prot
	PTHR11506	UniProtKB/Swiss-Prot
Pfam	Lamp	UniProtKB/Swiss-Prot
PhenoGen	Lamp5	PhenoGen
PROSITE	LAMP_1	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000005457	RatGTEx
UniProt	LAMP5_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2011-12-06	Lamp5	lysosomal-associated membrane protein family, member 5	RGD1306991	similar to Protein C20orf103 precursor	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-12-06	RGD1306991	similar to Protein C20orf103 precursor	RGD1306991_predicted	similar to Protein C20orf103 precursor (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-20	RGD1306991_predicted	similar to Protein C20orf103 precursor (predicted)	LOC362220_predicted		Symbol and Name status set to approved	1331353	APPROVED
2005-01-12	LOC362220_predicted	similar to Protein C20orf103 precursor (predicted)			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar