Cmbl (carboxymethylenebutenolidase homolog) - Rat Genome Database

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Gene: Cmbl (carboxymethylenebutenolidase homolog) Rattus norvegicus
Analyze
Symbol: Cmbl
Name: carboxymethylenebutenolidase homolog
RGD ID: 1306952
Description: Predicted to enable hydrolase activity. Predicted to be located in cytosol and membrane. Orthologous to human CMBL (carboxymethylenebutenolidase homolog); INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,2',4,4'-Tetrabromodiphenyl ether.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Ab2-225; carboxymethylenebutenolidase homolog (Pseudomonas); carboxymethylenebutenolidase-like; liver regeneration-related protein LRRG072; LOC310201; MGC95111; RGD1306952; similar to Ab2-225
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2282,569,257 - 82,591,007 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl282,571,888 - 82,591,009 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx289,611,485 - 89,633,262 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0287,733,060 - 87,754,837 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0282,789,344 - 82,811,125 (+)NCBIRnor_WKY
Rnor_6.0284,645,084 - 84,666,836 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl284,645,084 - 84,666,835 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02104,317,820 - 104,339,572 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4283,659,292 - 83,681,042 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1283,617,546 - 83,626,004 (+)NCBI
Celera278,093,828 - 78,114,831 (+)NCBICelera
Cytogenetic Map2q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-methylcholine  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-chloropropane-1,2-diol  (EXP)
5-aza-2'-deoxycytidine  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrylamide  (ISO)
adefovir pivoxil  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (EXP,ISO)
amiodarone  (EXP,ISO)
ampicillin  (EXP)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
benzbromarone  (EXP)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (EXP,ISO)
butanal  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
carbon nanotube  (ISO)
chloroacetaldehyde  (ISO)
cidofovir anhydrous  (ISO)
cisplatin  (ISO)
clodronic acid  (ISO)
clofibrate  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
dichloroacetic acid  (ISO)
dioxygen  (ISO)
endosulfan  (EXP)
enzyme inhibitor  (ISO)
ethanol  (ISO)
fenofibrate  (EXP)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
gentamycin  (EXP)
glafenine  (EXP)
ibuprofen  (EXP,ISO)
ifosfamide  (ISO)
ivermectin  (ISO)
L-ethionine  (EXP)
lead diacetate  (ISO)
levofloxacin  (EXP)
lipopolysaccharide  (ISO)
menadione  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
metformin  (EXP)
methapyrilene  (EXP)
metronidazole  (EXP)
morphine  (EXP)
Muraglitazar  (EXP)
N-nitrosodiethylamine  (ISO)
N-nitrosomorpholine  (EXP)
nefazodone  (EXP)
neomycin  (EXP)
nickel atom  (ISO)
nickel sulfate  (ISO)
nimesulide  (EXP)
nitrofen  (EXP)
omeprazole  (EXP)
ozone  (ISO)
paracetamol  (ISO)
pentanal  (ISO)
pirinixic acid  (EXP,ISO)
progesterone  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sunitinib  (ISO)
temozolomide  (ISO)
Tesaglitazar  (EXP)
testosterone  (EXP,ISO)
tetrachloromethane  (EXP,ISO)
thapsigargin  (EXP)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichloroethene  (EXP)
troglitazone  (EXP,ISO)
trovafloxacin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vancomycin  (EXP)
vinclozolin  (EXP)
zinc protoporphyrin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytosol  (IEA)
membrane  (IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
2. GOA pipeline RGD automated data pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:12477932   PMID:19056867   PMID:23376485  


Genomics

Comparative Map Data
Cmbl
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2282,569,257 - 82,591,007 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl282,571,888 - 82,591,009 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx289,611,485 - 89,633,262 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0287,733,060 - 87,754,837 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0282,789,344 - 82,811,125 (+)NCBIRnor_WKY
Rnor_6.0284,645,084 - 84,666,836 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl284,645,084 - 84,666,835 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02104,317,820 - 104,339,572 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4283,659,292 - 83,681,042 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1283,617,546 - 83,626,004 (+)NCBI
Celera278,093,828 - 78,114,831 (+)NCBICelera
Cytogenetic Map2q22NCBI
CMBL
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38510,277,595 - 10,307,902 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl510,275,875 - 10,307,902 (-)EnsemblGRCh38hg38GRCh38
GRCh37510,277,707 - 10,308,014 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36510,330,707 - 10,361,168 (-)NCBINCBI36Build 36hg18NCBI36
Celera510,315,760 - 10,346,293 (-)NCBICelera
Cytogenetic Map5p15.2NCBI
HuRef510,262,174 - 10,292,589 (-)NCBIHuRef
CHM1_1510,277,580 - 10,308,025 (-)NCBICHM1_1
T2T-CHM13v2.0510,216,896 - 10,247,204 (-)NCBIT2T-CHM13v2.0
Cmbl
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391531,565,314 - 31,590,266 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1531,565,535 - 31,590,265 (+)EnsemblGRCm39 Ensembl
GRCm381531,565,342 - 31,590,119 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1531,565,389 - 31,590,119 (+)EnsemblGRCm38mm10GRCm38
MGSCv371531,498,667 - 31,519,874 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361531,513,494 - 31,534,708 (+)NCBIMGSCv36mm8
Celera1532,260,559 - 32,283,934 (+)NCBICelera
Cytogenetic Map15B2NCBI
Cmbl
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955426144,997 - 166,970 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955426146,749 - 166,922 (-)NCBIChiLan1.0ChiLan1.0
CMBL
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1510,451,378 - 10,481,731 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl510,451,369 - 10,481,731 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0510,594,567 - 10,623,214 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
CMBL
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1344,008,022 - 4,031,637 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl344,021,118 - 4,033,904 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha348,510,530 - 8,534,153 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0343,910,437 - 3,934,077 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl343,910,479 - 3,934,068 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1343,962,357 - 3,985,932 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0343,941,665 - 3,965,258 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0344,172,202 - 4,195,845 (+)NCBIUU_Cfam_GSD_1.0
Cmbl
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213237,013,266 - 237,031,583 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366432,371,187 - 2,386,228 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049366432,371,191 - 2,389,506 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CMBL
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1672,170,885 - 72,204,364 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11672,170,813 - 72,204,695 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
CMBL
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.149,816,762 - 9,847,077 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl49,814,074 - 9,846,278 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606418,696,945 - 18,729,179 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cmbl
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247517,630,779 - 7,648,996 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247517,630,773 - 7,652,328 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cmbl
91 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:51
Count of miRNA genes:47
Interacting mature miRNAs:51
Transcripts:ENSRNOT00000015448
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61355Bp36Blood pressure QTL 362.9blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)25873687102844969Rat
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)225413423143657569Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
1354603Bp243Blood pressure QTL 2433.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)226917817127469484Rat
2290453Scl55Serum cholesterol level QTL 552.83blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)226917817136917119Rat
61371Edpm1Estrogen-dependent pituitary mass QTL 140.05pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)23513484188029593Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)240067944102785628Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)240067944102785628Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)240067944102785628Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)240067944102785628Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)240067944102785628Rat
2293835Kiddil5Kidney dilation QTL 53.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607157142209Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607182042367Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)243154682202446871Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)243154682202446871Rat
2293676Bmd19Bone mineral density QTL 1910.70.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)243162366111362592Rat
2293682Bmd24Bone mineral density QTL 248.90.0001femur mineral mass (VT:0010011)cortical volumetric bone mineral density (CMO:0001730)243162366111362592Rat
2293671Bss44Bone structure and strength QTL 4410.970.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)243162366148478373Rat
631208Bw1Body weight QTL15.09mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)24317101783575226Rat
1354601Slep1Serum leptin concentration QTL 15.39blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)243171017184114403Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)246123260202447032Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)256043031202447032Rat
1558648Smcn1Smooth muscle cell number QTL 10.039blood vessel smooth muscle cell quantity (VT:0010525)aorta smooth muscle cell count per unit vessel length (CMO:0001646)259134147127460910Rat
5684990Bmd82Bone mineral density QTL 822.8tibia mineral mass (VT:1000283)bone mineral content (CMO:0001554)259324377103795077Rat
5684996Bmd85Bone mineral density QTL 854.70.024tibia mineral mass (VT:1000283)bone mineral density (CMO:0001226)259324377103795077Rat
61438Cia7Collagen induced arthritis QTL 74.60.0001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)259324377141596857Rat
631500Bp99Blood pressure QTL 992.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)259324719102755241Rat
1578777Stresp15Stress response QTL 1520.05blood aldosterone amount (VT:0005346)plasma aldosterone level (CMO:0000551)259846005104846005Rat
2306903Bp336Blood pressure QTL 3360.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)264366971109366971Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118275202447032Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
7411551Bw131Body weight QTL 13129.60.001body mass (VT:0001259)body weight gain (CMO:0000420)267942638112942638Rat
1558653Prcr1Prostate cancer resistance QTL 15prostate integrity trait (VT:0010571)area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)272532993157142209Rat
1359034Bp274Blood pressure QTL 274arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)27478666494359546Rat
1359034Bp274Blood pressure QTL 274arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)27478666494359546Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)274786664206665859Rat
61465Bp13Blood pressure QTL 133.3blood pressure trait (VT:0000183)diastolic blood pressure (CMO:0000005)276539322102785628Rat
61465Bp13Blood pressure QTL 133.3blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)276539322102785628Rat
631198Cm22Cardiac mass QTL 224.30.0008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)276539322150540526Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)276539322202447032Rat
2299162Iddm32Insulin dependent diabetes mellitus QTL 322.36blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)278665616143657569Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)278665619219826953Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
61392Bp6Blood pressure QTL 67arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)280270434125270434Rat
1598865Bp296Blood pressure QTL 2962.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)281018907126018907Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)281689826221035911Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)281754530222436696Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
1578772Stresp14Stress response QTL 1450.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)282345893130923501Rat

Markers in Region
RH128841  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2282,590,801 - 82,590,964 (+)MAPPERmRatBN7.2
Rnor_6.0284,666,630 - 84,666,792NCBIRnor6.0
Rnor_5.02104,339,366 - 104,339,528UniSTSRnor5.0
RGSC_v3.4283,680,837 - 83,680,999UniSTSRGSC3.4
Celera278,114,626 - 78,114,788UniSTS
RH 3.4 Map2516.7UniSTS
Cytogenetic Map2q22UniSTS
RH129775  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2282,590,802 - 82,590,963 (+)MAPPERmRatBN7.2
Rnor_6.0284,666,631 - 84,666,791NCBIRnor6.0
Rnor_5.02104,339,367 - 104,339,527UniSTSRnor5.0
RGSC_v3.4283,680,838 - 83,680,998UniSTSRGSC3.4
Celera278,114,627 - 78,114,787UniSTS
RH 3.4 Map2517.1UniSTS
Cytogenetic Map2q22UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 23 47 35 4 35 8 11 25 23 10 11 8
Low 20 10 6 15 6 35 12 31
Below cutoff 14

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000015448   ⟹   ENSRNOP00000015448
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl282,572,352 - 82,591,007 (+)Ensembl
Rnor_6.0 Ensembl284,645,084 - 84,666,835 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000118086   ⟹   ENSRNOP00000079112
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl282,571,888 - 82,591,009 (+)Ensembl
RefSeq Acc Id: NM_001008770   ⟹   NP_001008770
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2282,569,257 - 82,591,007 (+)NCBI
Rnor_6.0284,645,084 - 84,666,835 (+)NCBI
Rnor_5.02104,317,820 - 104,339,572 (+)NCBI
RGSC_v3.4283,659,292 - 83,681,042 (+)RGD
Celera278,093,828 - 78,114,831 (+)RGD
Sequence:
RefSeq Acc Id: XM_006232097   ⟹   XP_006232159
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2282,572,006 - 82,591,007 (+)NCBI
Rnor_6.0284,646,229 - 84,666,836 (+)NCBI
Rnor_5.02104,317,820 - 104,339,572 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_001008770   ⟸   NM_001008770
- UniProtKB: Q7TP52 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006232159   ⟸   XM_006232097
- Peptide Label: isoform X1
- UniProtKB: Q7TP52 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000015448   ⟸   ENSRNOT00000015448
RefSeq Acc Id: ENSRNOP00000079112   ⟸   ENSRNOT00000118086
Protein Domains
DLH

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q7TP52-F1-model_v2 AlphaFold Q7TP52 1-245 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691211
Promoter ID:EPDNEW_R1736
Type:initiation region
Name:Cmbl_1
Description:carboxymethylenebutenolidase homolog
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0284,645,063 - 84,645,123EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1306952 AgrOrtholog
BioCyc Gene G2FUF-53861 BioCyc
Ensembl Genes ENSRNOG00000011260 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000015448 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000079112.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000015448 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000118086.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.1820 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7127481 IMAGE-MGC_LOAD
InterPro AB_hydrolase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CMBL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Dienelactn_hydro UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:310201 UniProtKB/Swiss-Prot
MGC_CLONE MGC:95111 IMAGE-MGC_LOAD
NCBI Gene 310201 ENTREZGENE
PANTHER PTHR46812 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam DLH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cmbl PhenoGen
Superfamily-SCOP SSF53474 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5ZMF1_RAT UniProtKB/TrEMBL
  CMBL_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-06-29 Cmbl  carboxymethylenebutenolidase homolog  Cmbl  carboxymethylenebutenolidase homolog (Pseudomonas)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-07 Cmbl  carboxymethylenebutenolidase homolog (Pseudomonas)  RGD1306952  similar to Ab2-225  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 RGD1306952  similar to Ab2-225  RGD1306952_predicted  similar to Ab2-225 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-20 RGD1306952_predicted  similar to Ab2-225 (predicted)  LOC310201_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC310201_predicted  similar to Ab2-225 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL