C1qc (complement C1q C chain) - Rat Genome Database

Name: C1qc
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: C1qc (complement C1q C chain) Rattus norvegicus

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Symbol:

C1qc

Name:

complement C1q C chain

RGD ID:

1306828

Description:

Predicted to be involved in complement activation, classical pathway; negative regulation of myeloid leukocyte differentiation; and synapse pruning. Located in synapse. Orthologous to human C1QC (complement C1q C chain); PARTICIPATES IN Chagas disease pathway; coagulation cascade pathway; complement system pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 17beta-estradiol 3-benzoate.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

Adib; adiponectin b; C1qg; complement C1q subcomponent subunit C; complement component 1, q subcomponent, C chain; complement component 1, q subcomponent, gamma polypeptide; LOC362634; MGC105681

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	154,410,845 - 154,414,208 (-)	NCBI		GRCr8
mRatBN7.2	5	149,127,412 - 149,130,757 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	149,127,415 - 149,131,017 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	5	151,825,173 - 151,828,528 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	153,599,460 - 153,602,815 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	153,581,457 - 153,584,813 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	155,255,013 - 155,258,631 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	155,255,005 - 155,258,392 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	5	159,017,512 - 159,021,130 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	5	155,656,104 - 155,659,430 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	5	155,666,143 - 155,669,469 (-)	NCBI
Celera	5	147,525,168 - 147,528,479 (-)	NCBI		Celera
Cytogenetic Map	5	q36	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

3-hydroxy-3-methylglutaryl-CoA lyase deficiency (ISO)

C1q Deficiency (ISO)

C1q Deficiency 3 (ISO)

congenital disorder of glycosylation Ir (ISO)

COVID-19 (ISO)

Drug Hypersensitivity Syndrome (ISO)

Experimental Liver Cirrhosis (ISO)

genetic disease (ISO)

hepatitis C (ISO)

hyperprolinemia type 2 (ISO)

metabolic dysfunction and alcohol associated liver disease (ISO)

metabolic dysfunction-associated steatotic liver disease (ISO)

Parkinson's disease 6 (ISO)

Stevens-Johnson syndrome (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

1,1-dichloroethene (ISO)

1,2-dimethylhydrazine (ISO)

1-naphthyl isothiocyanate (EXP)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (EXP,ISO)

17beta-estradiol 3-benzoate (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4,6-tribromophenol (ISO)

2,4,6-trinitrobenzenesulfonic acid (ISO)

2,4-dibromophenyl 2,4,5-tribromophenyl ether (ISO)

3,3',4,4',5-pentachlorobiphenyl (EXP)

3,3',5,5'-tetrabromobisphenol A (ISO)

3H-1,2-dithiole-3-thione (EXP)

4,4'-diaminodiphenylmethane (EXP)

4,4'-sulfonyldiphenol (ISO)

4-amino-2,6-dinitrotoluene (EXP)

5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole (EXP)

7,12-dimethyltetraphene (ISO)

acetamide (EXP)

acrylamide (EXP)

aflatoxin B1 (EXP,ISO)

amitriptyline (EXP)

antirheumatic drug (ISO)

aristolochic acid A (EXP)

azoxystrobin (EXP)

benzo[a]pyrene (EXP,ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

C60 fullerene (EXP)

cadmium atom (ISO)

cadmium dichloride (EXP)

calcitriol (ISO)

cannabidiol (EXP)

captan (ISO)

carbon nanotube (ISO)

chlordecone (ISO)

chlormequat chloride (EXP)

chlorpyrifos (EXP)

copper atom (ISO)

copper(0) (ISO)

cyclosporin A (EXP)

diclofenac (ISO)

disodium selenite (ISO)

diuron (EXP)

doxorubicin (EXP)

endosulfan (EXP)

ethanol (ISO)

flutamide (EXP)

folpet (ISO)

gentamycin (EXP)

glyphosate (EXP)

imidacloprid (EXP)

indoles (EXP)

irinotecan (ISO)

ketamine (EXP)

lansoprazole (EXP)

lidocaine (EXP)

lipopolysaccharide (ISO)

medroxyprogesterone acetate (ISO)

methidathion (ISO)

N-nitrosodiethylamine (EXP,ISO)

N-nitrosodimethylamine (EXP)

nickel atom (ISO)

nickel sulfate (ISO)

nimesulide (EXP)

omeprazole (EXP)

ozone (ISO)

paclitaxel (EXP)

pantoprazole (EXP)

paracetamol (ISO)

perfluorooctane-1-sulfonic acid (ISO)

phenobarbital (ISO)

pirinixic acid (ISO)

pravastatin (EXP,ISO)

probucol (ISO)

rabeprazole (EXP)

resveratrol (EXP)

silicon dioxide (ISO)

sirolimus (EXP)

Soman (EXP)

streptozocin (EXP)

tacrolimus hydrate (ISO)

testosterone (EXP,ISO)

tetrachloromethane (ISO)

thiabendazole (EXP)

titanium dioxide (ISO)

trimellitic anhydride (ISO)

triphenyl phosphate (EXP)

troglitazone (ISO)

valproic acid (ISO)

vinclozolin (EXP)

zinc atom (ISO)

zinc(0) (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

biological_process (ND)

complement activation, classical pathway (IEA,ISO)

innate immune response (IEA)

negative regulation of granulocyte differentiation (IEA,ISO)

negative regulation of macrophage differentiation (IEA,ISO)

synapse pruning (ISO)

Cellular Component

collagen trimer (IEA)

complement component C1q complex (IEA,ISO)

extracellular region (IEA,ISO)

extrinsic component of postsynaptic membrane (ISO)

extrinsic component of presynaptic membrane (ISO)

glutamatergic synapse (ISO)

postsynapse (ISO)

synapse (IDA,ISO)

Molecular Function

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

Chagas disease pathway (IEA)

coagulation cascade pathway (IEA)

complement system pathway (IEA)

prion disease pathway (IEA)

Staphylococcus aureus infection pathway (IEA)

systemic lupus erythematosus pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
2.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
3.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
4.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
5.	GOA pipeline	RGD automated data pipeline
6.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
8.	Comprehensive gene review and curation	RGD comprehensive gene curation
9.	The classical complement cascade mediates CNS synapse elimination.	Stevens B, etal., Cell. 2007 Dec 14;131(6):1164-78. doi: 10.1016/j.cell.2007.10.036.

Additional References at PubMed

PMID:8464426	PMID:10961870	PMID:12477932	PMID:15489334	PMID:22516433	PMID:22664934	PMID:23376485	PMID:24006456	PMID:24939307	PMID:25931508	PMID:26316108	PMID:27033548
PMID:29476059

Genomics

Comparative Map Data

C1qc
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	154,410,845 - 154,414,208 (-)	NCBI		GRCr8
mRatBN7.2	5	149,127,412 - 149,130,757 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	149,127,415 - 149,131,017 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	5	151,825,173 - 151,828,528 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	153,599,460 - 153,602,815 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	153,581,457 - 153,584,813 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	155,255,013 - 155,258,631 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	155,255,005 - 155,258,392 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	5	159,017,512 - 159,021,130 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	5	155,656,104 - 155,659,430 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	5	155,666,143 - 155,669,469 (-)	NCBI
Celera	5	147,525,168 - 147,528,479 (-)	NCBI		Celera
Cytogenetic Map	5	q36	NCBI

C1QC
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	22,643,633 - 22,648,108 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	22,643,014 - 22,648,110 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	22,970,126 - 22,974,601 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	22,842,734 - 22,847,190 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	1	22,715,452 - 22,719,908	NCBI
Celera	1	21,294,833 - 21,299,316 (+)	NCBI		Celera
Cytogenetic Map	1	p36.12	NCBI
HuRef	1	21,214,476 - 21,218,943 (+)	NCBI		HuRef
CHM1_1	1	23,082,633 - 23,087,117 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	1	22,468,666 - 22,473,122 (+)	NCBI		T2T-CHM13v2.0

C1qc
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	4	136,617,115 - 136,620,225 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	4	136,617,115 - 136,620,376 (-)	Ensembl		GRCm39 Ensembl
GRCm38	4	136,889,801 - 136,892,936 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	4	136,889,804 - 136,893,065 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	4	136,445,717 - 136,448,829 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	4	136,161,886 - 136,164,949 (-)	NCBI		MGSCv36	mm8
Celera	4	135,097,110 - 135,100,232 (-)	NCBI		Celera
Cytogenetic Map	4	D3	NCBI
cM Map	4	69.05	NCBI

C1qc
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955452	2,758,821 - 2,762,522 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955452	2,759,079 - 2,762,522 (+)	NCBI	ChiLan1.0	ChiLan1.0

C1QA
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	204,307,981 - 204,311,074 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	203,410,999 - 203,414,092 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	21,821,927 - 21,825,020 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	22,770,557 - 22,773,682 (+)	NCBI	panpan1.1	PanPan1.1	panPan2

C1QC
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	2	76,660,039 - 76,664,602 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	2	76,660,035 - 76,664,577 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	2	73,164,924 - 73,169,492 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	2	77,219,290 - 77,223,860 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	2	77,219,286 - 77,223,830 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	2	74,040,178 - 74,044,743 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	2	75,048,597 - 75,053,163 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	2	76,052,212 - 76,056,780 (-)	NCBI		UU_Cfam_GSD_1.0

LOC101960229
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	42,188,570 - 42,192,175 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936474	8,013,359 - 8,016,959 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936474	8,013,395 - 8,016,937 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

C1QC
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	80,592,473 - 80,597,452 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	6	80,592,591 - 80,597,464 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	74,616,498 - 74,621,232 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

C1QC
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	110,016,355 - 110,021,123 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	20	110,016,362 - 110,020,854 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666033	6,293,137 - 6,297,626 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

C1qc
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624764	7,369,338 - 7,373,436 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624764	7,369,365 - 7,373,238 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in C1qc
20 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	59
Count of miRNA genes:	45
Interacting mature miRNAs:	56
Transcripts:	ENSRNOT00000017065
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
10053720	Scort26	Serum corticosterone level QTL 26	2.06	0.0147	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	5	124965598	166875058	Rat
8552960	Pigfal15	Plasma insulin-like growth factor 1 level QTL 15			blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	5	111416838	156416838	Rat
2302369	Scl60	Serum cholesterol level QTL 60	3.13		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	5	143608201	161165651	Rat
631562	Apr2	Acute phase response QTL 2	3.7		blood murinoglobulin 1 amount (VT:0010597)	plasma murinoglobulin 1 level (CMO:0001931)	5	135927956	166875058	Rat
61444	Strs2	Sensitivity to stroke QTL 2	4.7		cerebrum integrity trait (VT:0010549)	post-insult time to onset of cerebrovascular lesion (CMO:0002343)	5	135929696	166875058	Rat
1300119	Bp180	Blood pressure QTL 180	3.82		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	5	144358090	157869054	Rat
70156	Niddm30	Non-insulin dependent diabetes mellitus QTL 30	3.98		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	5	129132447	151006154	Rat
8552908	Pigfal4	Plasma insulin-like growth factor 1 level QTL 4	6.6		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	5	128506074	166875058	Rat
61393	Bp7	Blood pressure QTL 7	4.5	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	60293434	161481680	Rat
7794791	Mcs33	Mammary carcinoma susceptibility QTL 33	1.93		mammary gland integrity trait (VT:0010552)	mammary tumor incidence/prevalence measurement (CMO:0000946)	5	131345754	166875058	Rat
7207486	Bss109	Bone structure and strength QTL 109			femur strength trait (VT:0010010)	femur total energy absorbed before break (CMO:0001677)	5	106906205	151906205	Rat
7207481	Bss106	Bone structure and strength QTL 106	7.9		femur strength trait (VT:0010010)	femur ultimate force (CMO:0001675)	5	106906205	151906205	Rat
1302790	Scl20	Serum cholesterol level QTL 20	6.4	0.0001	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	5	82394392	166664054	Rat
1598861	Cm64	Cardiac mass QTL 64	2.9		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	5	127798274	166875058	Rat
1578766	Tcas11	Tongue tumor susceptibility QTL 11	4.12		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	5	46711509	161317411	Rat
631263	Cm24	Cardiac mass QTL 24	3.5		heart mass (VT:0007028)	heart left ventricle weight to body weight ratio (CMO:0000530)	5	143799107	158428037	Rat
631505	Bp103	Blood pressure QTL 103	3.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	132717196	165560427	Rat
1549838	Bss4	Bone structure and strength QTL 4	9.2		femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	5	106906205	151906205	Rat
1641920	Colcs1	Colorectal carcinoma susceptibility QTL 1	2.99	0.0055	intestine integrity trait (VT:0010554)	benign colorectal tumor surface area measurement (CMO:0001799)	5	121846814	166846814	Rat
8694169	Bw148	Body weight QTL 148	5	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	5	128506074	166875058	Rat
1331721	Bp210	Blood pressure QTL 210	3.413		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	5	143069996	166846814	Rat
8657050	Bw146	Body weight QTL 146	19.84	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	5	108938288	153938288	Rat
1576314	Eutr1	Estrogen induced uterine response QTL 1			uterus integrity trait (VT:0010575)	pyometritis severity score (CMO:0002009)	5	2138965	166875058	Rat
2317056	Wbc3	White blood cell count QTL 3	2.51	0.01	leukocyte quantity (VT:0000217)	white blood cell count (CMO:0000027)	5	105999803	150999803	Rat
634349	Bp139	Blood pressure QTL 139		0.001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	128924607	166875058	Rat
724525	Bp147	Blood pressure QTL 147	4.3	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	126424772	166875058	Rat
1598847	Cm62	Cardiac mass QTL 62	3.4		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	5	108845856	153845856	Rat
2293642	Bss37	Bone structure and strength QTL 37	4.64	0.0001	femur strength trait (VT:0010010)	femur ultimate force (CMO:0001675)	5	120740824	151018848	Rat
738018	Anxrr4	Anxiety related response QTL 4	5.1		exploratory behavior trait (VT:0010471)	percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)	5	130130159	166875058	Rat
2313096	Bmd78	Bone mineral density QTL 78	3.1	0.0001	tibia mineral mass (VT:1000283)	total volumetric bone mineral density (CMO:0001728)	5	144377876	161317411	Rat
7207488	Bss110	Bone structure and strength QTL 1	8.4		femur strength trait (VT:0010010)	femur stiffness (CMO:0001674)	5	106906205	151906205	Rat
8694441	Bw169	Body weight QTL 169	17.61	0.001	retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	5	111416838	156416838	Rat
7207491	Bss112	Bone structure and strength QTL 112	7		femur morphology trait (VT:0000559)	femur midshaft cortical cross-sectional area (CMO:0001663)	5	106906205	151906205	Rat
8694389	Bw160	Body weight QTL 160	6.17	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	5	111416838	156416838	Rat
1354598	Srn6	Serum renin concentration QTL 6	3.8		blood renin amount (VT:0003349)	plasma renin activity level (CMO:0000116)	5	69540295	151018848	Rat
8694198	Abfw3	Abdominal fat weight QTL 3	16.13	0.001	visceral adipose mass (VT:0010063)	abdominal fat pad weight to body weight ratio (CMO:0000095)	5	111416838	156416838	Rat
1298089	Scl14	Serum cholesterol level QTL 14	5.8	0.0004	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	5	108845856	153845856	Rat
1598819	Bp292	Blood pressure QTL 292	4.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	127798274	166875058	Rat

Markers in Region

RH133915

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	5	149,127,433 - 149,127,637 (+)	MAPPER	mRatBN7.2
Rnor_6.0	5	155,255,035 - 155,255,238	NCBI	Rnor6.0
Rnor_5.0	5	159,017,534 - 159,017,737	UniSTS	Rnor5.0
RGSC_v3.4	5	155,656,114 - 155,656,317	UniSTS	RGSC3.4
Celera	5	147,525,178 - 147,525,381	UniSTS
RH 3.4 Map	5	1008.4	UniSTS
Cytogenetic Map	5	q36	UniSTS

AA851367

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	5	149,127,432 - 149,127,632 (+)	MAPPER	mRatBN7.2
Rnor_6.0	5	155,255,034 - 155,255,233	NCBI	Rnor6.0
Rnor_5.0	5	159,017,533 - 159,017,732	UniSTS	Rnor5.0
RGSC_v3.4	5	155,656,113 - 155,656,312	UniSTS	RGSC3.4
Celera	5	147,525,177 - 147,525,376	UniSTS
RH 3.4 Map	5	1008.8	UniSTS
Cytogenetic Map	5	q36	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001008524	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006239225	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC113790	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC086409	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473968	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ218827	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ219610	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ220269	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ228978	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000005	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	LT963068	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000017065 ⟹ ENSRNOP00000017065

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	5	149,127,415 - 149,130,650 (-)	Ensembl
Rnor_6.0 Ensembl	5	155,255,005 - 155,258,392 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000100767 ⟹ ENSRNOP00000080593

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	5	149,127,415 - 149,130,759 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000108361 ⟹ ENSRNOP00000083386

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	5	149,127,415 - 149,131,017 (-)	Ensembl

RefSeq Acc Id:

NM_001008524 ⟹ NP_001008524

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	154,410,845 - 154,414,208 (-)	NCBI
mRatBN7.2	5	149,127,412 - 149,130,757 (-)	NCBI
Rnor_6.0	5	155,255,025 - 155,258,351 (-)	NCBI
Rnor_5.0	5	159,017,512 - 159,021,130 (-)	NCBI
RGSC_v3.4	5	155,656,104 - 155,659,430 (-)	RGD
Celera	5	147,525,168 - 147,528,479 (-)	RGD

Sequence:

show sequence

GCCTGAAGTCCCCTACATGCTCAGGATGGTTGTAGGAACCAGCTGCCAGCCCCAGCATGGACTC
TACCTGCTGCTGCTCCTTCTGGCCCTACCCCTCAGGAGCCAGGCCAACGCTGGCTGCTATGGGA
TCCCAGGGATGCCAGGCCTGCCGGGAACCCCTGGGAAGGATGGGCATGATGGACTTCAGGGGCC
CAAGGGTGAGCCGGGAATCCCAGCCATCCCTGGGACACAAGGACCCAAGGGTCAGAAGGGCGAG
CCGGGTATGCCTGGCCATCGTGGGAAAAACGGCCCCATGGGGACCTCTGGGTCGCCAGGGGATC
CAGGCCCCAGGGGTCCTCCCGGGGAGCCGGGTGAGGAGGGTCGATACAAACAGAAGCATCAGTC
GGTGTTCACGGTCACCCGGCAGACCGCGCAGTACCCAGCGGCCAATGGCCTTGTCAAGTTCAAT
TCCGCCATCACCAATCCTCAGGGGGATTACAACACAAACACGGGGAAGTTCACCTGCAAAGTGC
CCGGCCTCTACTACTTCGTCCACCACACATCCCAGACGGCCAACCTGTGCGTGCAGCTGCTCCT
CAACAATGCCAAGGTGACCAGCTTCTGCGACCACATGTCCAACAGCAAGCAGGTCAGCTCAGGA
GGAGTACTCCTGCGGCTGCAGAGGGGCGACGAGGTGTGGCTGGCCGTCAACGACTACAACGGCA
TGGTGGGCACTGAGGGCTCTGACAGCGTCTTCTCTGGTTTCCTACTGTTTCCTGACTAGAATGG
CAGGCTGGGTCCAGCACCCGGACGCCCGCCTCGCTCCCTCTGCTTTCCCCATCCTCACTCAGAC
CTCTTCCTTCAGGAAGTCCACCCTGGTTCCTGACCCATCAGCCCTCTGTCTCCTCAGAGTTTCT
CTGGGAATCACTGACTGGTTCCATTCCAGTGGCAGTTTATCGAGACCTTTATGAGACTATTTTT
TTTTCAGGTGGGAAGAGAGAAAAATAAATAGATCACTAAATAAATATGCCTGGCCCAGATTTCT
CACTAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001008524	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH86409	(Get FASTA)	NCBI Sequence Viewer
	EDL80826	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000017065.5
	ENSRNOP00000080593.1
	ENSRNOP00000083386.1
GenBank Protein	P31722	(Get FASTA)	NCBI Sequence Viewer
	SOR70286	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_001008524 ⟸ NM_001008524
- Peptide Label:	precursor
- UniProtKB:	Q5RJZ8 (UniProtKB/Swiss-Prot), P31722 (UniProtKB/Swiss-Prot), A0A8I5ZWV4 (UniProtKB/TrEMBL), A6ITC5 (UniProtKB/TrEMBL)
- Sequence:	show sequence MVVGTSCQPQHGLYLLLLLLALPLRSQANAGCYGIPGMPGLPGTPGKDGHDGLQGPKGEPGIPA IPGTQGPKGQKGEPGMPGHRGKNGPMGTSGSPGDPGPRGPPGEPGEEGRYKQKHQSVFTVTRQT AQYPAANGLVKFNSAITNPQGDYNTNTGKFTCKVPGLYYFVHHTSQTANLCVQLLLNNAKVTSF CDHMSNSKQVSSGGVLLRLQRGDEVWLAVNDYNGMVGTEGSDSVFSGFLLFPD hide sequence

Ensembl Acc Id:

ENSRNOP00000017065 ⟸ ENSRNOT00000017065

Ensembl Acc Id:

ENSRNOP00000080593 ⟸ ENSRNOT00000100767

Ensembl Acc Id:

ENSRNOP00000083386 ⟸ ENSRNOT00000108361

Protein Domains

C1q Collagen-like

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P31722-F1-model_v2	AlphaFold	P31722	1-245	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13694174

Promoter ID:

EPDNEW_R4699

Type:

initiation region

Name:

C1qc_1

Description:

complement C1q C chain

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	5	155,258,398 - 155,258,458	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1306828	AgrOrtholog
BioCyc Gene	G2FUF-39488	BioCyc
Ensembl Genes	ENSRNOG00000012804	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000017065.6	UniProtKB/TrEMBL
	ENSRNOT00000100767.1	UniProtKB/TrEMBL
	ENSRNOT00000108361.1	UniProtKB/TrEMBL
Gene3D-CATH	2.60.120.40	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7306579	IMAGE-MGC_LOAD
InterPro	C1q_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Collagen	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Collagen/C1q_domain	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Tumour_necrosis_fac-like_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:362634	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:105681	IMAGE-MGC_LOAD
NCBI Gene	362634	ENTREZGENE
PANTHER	COMPLEMENT C1Q SUBCOMPONENT SUBUNIT C	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	EMILIN ELASTIN MICROFIBRIL INTERFACE-LOCATED PROTEIN ELASTIN MICROFIBRIL INTERFACER	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	C1q	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Collagen	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	C1qc	PhenoGen
PRINTS	COMPLEMNTC1Q	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	C1Q	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000012804	RatGTEx
SMART	C1Q	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF49842	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A0H2UHK1_RAT	UniProtKB/TrEMBL
	A0A3B0IYY4_RAT	UniProtKB/TrEMBL
	A0A8I5ZWV4	ENTREZGENE, UniProtKB/TrEMBL
	A6ITC5	ENTREZGENE, UniProtKB/TrEMBL
	C1QC_RAT	UniProtKB/Swiss-Prot, ENTREZGENE
	Q5RJZ8	ENTREZGENE
UniProt Secondary	Q5RJZ8	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-07-13	C1qc	complement C1q C chain	C1qc	complement component 1, q subcomponent, C chain	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-03-03	C1qc	complement component 1, q subcomponent, C chain	C1qg	complement component 1, q subcomponent, gamma polypeptide	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-12-06	C1qg	complement component 1, q subcomponent, gamma polypeptide	C1qg_predicted	complement component 1, q subcomponent, gamma polypeptide (predicted)	Symbol and Name updated	1559027	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - KEGG (archival)