Aldh1b1 (aldehyde dehydrogenase 1 family, member B1) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Aldh1b1 (aldehyde dehydrogenase 1 family, member B1) Rattus norvegicus
Analyze
Symbol: Aldh1b1
Name: aldehyde dehydrogenase 1 family, member B1
RGD ID: 1306737
Description: Predicted to enable aldehyde dehydrogenase (NAD+) activity. Predicted to be involved in aldehyde metabolic process. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in mitochondrion. Orthologous to human ALDH1B1 (aldehyde dehydrogenase 1 family member B1); PARTICIPATES IN disulfiram pharmacodynamics pathway; arginine and proline metabolic pathway; ascorbate and aldarate metabolic pathway; INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: aldehyde dehydrogenase 1B1; aldehyde dehydrogenase family 1 member B1; aldehyde dehydrogenase X, mitochondrial; LOC298079
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8564,859,000 - 64,864,008 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl564,858,934 - 64,864,365 (+)EnsemblGRCr8
mRatBN7.2560,063,370 - 60,068,378 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl560,063,225 - 60,068,378 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx562,037,951 - 62,042,973 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0563,857,464 - 63,862,486 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0563,826,704 - 63,831,726 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0561,382,351 - 61,387,359 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl561,382,351 - 61,387,358 (+)Ensemblrn6Rnor6.0
Rnor_5.0565,898,607 - 65,903,615 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4562,311,268 - 62,316,276 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera558,627,944 - 58,632,952 (+)NCBICelera
RGSC_v3.1562,311,446 - 62,316,454 (+)NCBI
Cytogenetic Map5q22NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1-aminobenzotriazole  (ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2-amino-4,6-dinitrotoluene  (EXP)
3,7-dihydropurine-6-thione  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-amino-2,6-dinitrotoluene  (EXP)
4-hydroperoxycyclophosphamide  (ISO)
8'-apo-beta,psi-caroten-8'-al  (ISO)
acetaldehyde  (ISO)
acetamide  (EXP)
acrylamide  (EXP,ISO)
actinomycin D  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsenous acid  (ISO)
Azoxymethane  (ISO)
benzo[a]pyrene  (ISO)
beta-naphthoflavone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
buspirone  (EXP)
butylated hydroxyanisole  (ISO)
cadmium dichloride  (EXP,ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
chlorohydrocarbon  (EXP)
chloroquine  (EXP)
choline  (EXP)
chromium(6+)  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
clofibric acid  (ISO)
cobalt dichloride  (EXP,ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
cyhalothrin  (EXP)
D-glucose  (ISO)
DDE  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP,ISO)
diclofenac  (ISO)
diethyl maleate  (EXP)
dorsomorphin  (ISO)
elemental selenium  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
epoxiconazole  (ISO)
ethoxyquin  (ISO)
fipronil  (EXP)
folic acid  (EXP,ISO)
formaldehyde  (ISO)
furan  (EXP)
genistein  (ISO)
glucose  (ISO)
hydrogen peroxide  (ISO)
indometacin  (EXP)
inulin  (ISO)
isoniazide  (ISO)
ivermectin  (ISO)
L-methionine  (EXP)
lead(0)  (ISO)
leflunomide  (EXP,ISO)
levofloxacin  (EXP)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
mercaptopurine  (EXP)
Mesaconitine  (EXP)
methyl methanesulfonate  (ISO)
methylmercury chloride  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
monobenzyl phthalate  (ISO)
Monobutylphthalate  (ISO)
monoethyl phthalate  (ISO)
N-nitrosodiethylamine  (ISO)
N-nitrosomorpholine  (EXP)
NAD zwitterion  (ISO)
NAD(+)  (ISO)
nefazodone  (EXP)
nickel dichloride  (EXP)
nimesulide  (EXP)
Nutlin-3  (ISO)
okadaic acid  (ISO)
ozone  (ISO)
paracetamol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
PhIP  (EXP)
pirinixic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
propanal  (ISO)
purine-6-thiol  (EXP)
quercetin  (ISO)
rac-1,2-dichloropropane  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
selenium atom  (ISO)
senecionine  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
sodium fluoride  (ISO)
Soman  (EXP)
spironolactone  (ISO)
tamibarotene  (ISO)
tamoxifen  (ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (EXP,ISO)
thiram  (ISO)
titanium dioxide  (ISO)
tolcapone  (EXP)
trichloroethene  (ISO)
triphenyl phosphate  (ISO)
trovafloxacin  (EXP)
urethane  (ISO)
valdecoxib  (EXP)
valproic acid  (EXP,ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytosol  (IEA,ISO)
mitochondrial matrix  (IEA)
mitochondrion  (IBA,IEA,ISO)
nucleoplasm  (IEA,ISO)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
5. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
6. GOA pipeline RGD automated data pipeline
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:12477932   PMID:15489334   PMID:18614015  


Genomics

Comparative Map Data
Aldh1b1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8564,859,000 - 64,864,008 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl564,858,934 - 64,864,365 (+)EnsemblGRCr8
mRatBN7.2560,063,370 - 60,068,378 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl560,063,225 - 60,068,378 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx562,037,951 - 62,042,973 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0563,857,464 - 63,862,486 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0563,826,704 - 63,831,726 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0561,382,351 - 61,387,359 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl561,382,351 - 61,387,358 (+)Ensemblrn6Rnor6.0
Rnor_5.0565,898,607 - 65,903,615 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4562,311,268 - 62,316,276 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera558,627,944 - 58,632,952 (+)NCBICelera
RGSC_v3.1562,311,446 - 62,316,454 (+)NCBI
Cytogenetic Map5q22NCBI
ALDH1B1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38938,392,702 - 38,398,661 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl938,392,702 - 38,398,661 (+)Ensemblhg38GRCh38
GRCh37938,392,699 - 38,398,658 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36938,382,702 - 38,388,658 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34938,382,701 - 38,388,655NCBI
Celera938,325,642 - 38,331,598 (+)NCBICelera
Cytogenetic Map9p13.1NCBI
HuRef938,345,031 - 38,351,031 (+)NCBIHuRef
CHM1_1938,394,431 - 38,400,431 (+)NCBICHM1_1
T2T-CHM13v2.0938,416,866 - 38,422,841 (+)NCBIT2T-CHM13v2.0
Aldh1b1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39445,799,022 - 45,804,608 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl445,799,022 - 45,804,604 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38445,799,022 - 45,804,608 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl445,799,022 - 45,804,604 (+)Ensemblmm10GRCm38
MGSCv37445,811,894 - 45,817,480 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36445,820,149 - 45,825,699 (+)NCBIMGSCv36mm8
Celera445,823,557 - 45,829,141 (+)NCBICelera
Cytogenetic Map4B1NCBI
cM Map424.35NCBI
Aldh1b1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541928,155,174 - 28,159,752 (-)Ensembl
ChiLan1.0NW_00495541928,155,174 - 28,159,752 (-)NCBIChiLan1.0ChiLan1.0
ALDH1B1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21186,193,222 - 86,198,060 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1986,199,143 - 86,204,000 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0938,239,413 - 38,244,751 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1939,161,296 - 39,167,289 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl939,164,392 - 39,165,945 (+)EnsemblpanPan2panpan1.1
ALDH1B1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11154,566,883 - 54,579,773 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1154,577,123 - 54,578,685 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1153,002,860 - 53,007,802 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01155,686,048 - 55,690,990 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1155,671,876 - 55,690,975 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11154,183,751 - 54,188,692 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01154,213,829 - 54,218,771 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01154,910,294 - 54,915,236 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Aldh1b1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947169,535,898 - 169,539,584 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365246,083,482 - 6,087,801 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365246,083,482 - 6,087,802 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ALDH1B1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1239,109,809 - 239,114,730 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11239,109,814 - 239,114,736 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21267,164,003 - 267,168,786 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ALDH1B1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11242,191,112 - 42,450,267 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1242,192,629 - 42,194,182 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603839,249,732 - 39,256,308 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Aldh1b1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248253,538,210 - 3,539,640 (-)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Aldh1b1
42 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:289
Count of miRNA genes:188
Interacting mature miRNAs:212
Transcripts:ENSRNOT00000015281
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578776Stresp18Stress response QTL 182.9thymus mass (VT:0004954)thymus wet weight (CMO:0000855)52795544072955440Rat
1298067Scl15Serum cholesterol level QTL 154.80.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)53321566578215665Rat
1300115Hrtrt7Heart rate QTL 72.76heart pumping trait (VT:2000009)heart rate (CMO:0000002)54786906290099692Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)540128307148607290Rat
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)51131345958Rat
1358353Srcrtb2Stress Responsive Cort Basal QTL 23.480.003blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)51887394774251464Rat
634305Mamtr1Mammary tumor resistance QTL 10.0001mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)512789751113558310Rat
1331801Rf33Renal function QTL 334.149kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)543726656129132602Rat
1598807Glom12Glomerulus QTL 122.7kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)53321566578215665Rat
1302786Kidm8Kidney mass QTL 828.15kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)53321566578215665Rat
6903292Stl28Serum triglyceride level QTL 282.60.0073blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)52851548973515489Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)546711509161317411Rat
1578767Stresp17Stress response QTL 174.30.01blood aldosterone amount (VT:0005346)plasma aldosterone level (CMO:0000551)52795544072955440Rat
7411561Bw134Body weight QTL 134240.001body mass (VT:0001259)body weight gain (CMO:0000420)54946360094463600Rat
1641922Alcrsp8Alcohol response QTL 8alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)53518915368564008Rat
2303615Vencon7Ventilatory control QTL 70.001respiration trait (VT:0001943)respiration rate (CMO:0000289)55098389595983895Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)550328551141643988Rat
1641912Alcrsp18Alcohol response QTL 18response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)535189153141643988Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
6903306Scl35Serum cholesterol QTL 352.60.0073blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)52851548973515489Rat
1576317Eutr2Estrogen induced uterine response QTL 20.01uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)534730116104251008Rat
7394712Emca13Estrogen-induced mammary cancer QTL 13mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)5982326699753708Rat
1331773Scl26Serum cholesterol level QTL 263.065blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)54372665686724018Rat
70189Mcs5Mammary carcinoma susceptibility QTL 510.51mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555805606132207589Rat
1331771Rf35Renal function QTL 354.36965kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)572947086724018Rat
61359EaexExperimental allergic encephalomyelitis QTL x3nervous system integrity trait (VT:0010566)post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)555715622100715622Rat
8662454Vetf3Vascular elastic tissue fragility QTL 327.4artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)5228222669540447Rat
2290448Scl54Serum cholesterol level QTL 542.93blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)531663789131345958Rat
61426Scl2Serum cholesterol level QTL 27.30.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)559793399143070159Rat
9589025Epfw7Epididymal fat weight QTL 720.660.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)54946360094463600Rat
2303574Gluco42Glucose level QTL 422blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)55349671998496719Rat
1331756Rf34Renal function QTL 344.16275kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)5190450412Rat
8552954Pigfal14Plasma insulin-like growth factor 1 level QTL 149blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)52122674466226744Rat
2316954Rf57Renal function QTL 570kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)55979352890450144Rat
1358895Bp254Blood pressure QTL 2543.60.0003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)558829236128034027Rat
2316959Gluco59Glucose level QTL 594.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)534944474113558310Rat
1600358Mamtr5Mammary tumor resistance QTL 5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)51887394763873947Rat
2316957Pur21Proteinuria QTL 216.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)559793528113558156Rat

Markers in Region
RH129900  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2560,068,159 - 60,068,341 (+)MAPPERmRatBN7.2
Rnor_6.0561,387,141 - 61,387,322NCBIRnor6.0
Rnor_5.0565,903,397 - 65,903,578UniSTSRnor5.0
RGSC_v3.4562,316,058 - 62,316,239UniSTSRGSC3.4
Celera558,632,734 - 58,632,915UniSTS
RH 3.4 Map5382.9UniSTS
Cytogenetic Map5q22UniSTS
GDB:280630  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2560,066,366 - 60,066,541 (+)MAPPERmRatBN7.2
Rnor_6.0561,385,348 - 61,385,522NCBIRnor6.0
Rnor_5.0565,901,604 - 65,901,778UniSTSRnor5.0
RGSC_v3.4562,314,265 - 62,314,439UniSTSRGSC3.4
Celera558,630,941 - 58,631,115UniSTS
Cytogenetic Map5q22UniSTS
UniSTS:546646  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2560,067,449 - 60,068,286 (+)MAPPERmRatBN7.2
Rnor_6.0561,386,431 - 61,387,267NCBIRnor6.0
Rnor_5.0565,902,687 - 65,903,523UniSTSRnor5.0
Celera558,632,024 - 58,632,860UniSTS
Cytogenetic Map5q22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 8 64 148 91 89 59 50 59 6 289 142 11 125 65 83 30 11 11

Sequence


Ensembl Acc Id: ENSRNOT00000015281   ⟹   ENSRNOP00000015282
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl564,858,934 - 64,864,365 (+)Ensembl
mRatBN7.2 Ensembl560,063,225 - 60,068,378 (+)Ensembl
Rnor_6.0 Ensembl561,382,351 - 61,387,358 (+)Ensembl
RefSeq Acc Id: NM_001011975   ⟹   NP_001011975
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8564,859,000 - 64,864,008 (+)NCBI
mRatBN7.2560,063,370 - 60,068,378 (+)NCBI
Rnor_6.0561,382,351 - 61,387,359 (+)NCBI
Rnor_5.0565,898,607 - 65,903,615 (+)NCBI
RGSC_v3.4562,311,268 - 62,316,276 (+)RGD
Celera558,627,944 - 58,632,952 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001011975 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH81884 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000015282
GenBank Protein Q66HF8 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001011975   ⟸   NM_001011975
- Peptide Label: precursor
- UniProtKB: Q66HF8 (UniProtKB/Swiss-Prot),   A6IJA2 (UniProtKB/TrEMBL),   G3V7I5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000015282   ⟸   ENSRNOT00000015281
Protein Domains
Aldehyde dehydrogenase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q66HF8-F1-model_v2 AlphaFold Q66HF8 1-519 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693705
Promoter ID:EPDNEW_R4229
Type:multiple initiation site
Name:Aldh1b1_1
Description:aldehyde dehydrogenase 1 family, member B1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0561,382,368 - 61,382,428EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1306737 AgrOrtholog
BioCyc Gene G2FUF-41436 BioCyc
Ensembl Genes ENSRNOG00000011497 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000015281 ENTREZGENE
Gene3D-CATH Aldehyde Dehydrogenase, Chain A, domain 1 UniProtKB/Swiss-Prot
  Aldehyde Dehydrogenase, Chain A, domain 2 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7108511 IMAGE-MGC_LOAD
InterPro Ald_DH/histidinol_DH UniProtKB/Swiss-Prot
  Ald_DH_C UniProtKB/Swiss-Prot
  Ald_DH_CS_CYS UniProtKB/Swiss-Prot
  Ald_DH_CS_GLU UniProtKB/Swiss-Prot
  Ald_DH_N UniProtKB/Swiss-Prot
  Aldehyde_DH_dom UniProtKB/Swiss-Prot
KEGG Report rno:298079 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93759 IMAGE-MGC_LOAD
NCBI Gene 298079 ENTREZGENE
PANTHER ALDEHYDE DEHYDROGENASE-RELATED UniProtKB/Swiss-Prot
Pfam Aldedh UniProtKB/Swiss-Prot
PhenoGen Aldh1b1 PhenoGen
PROSITE ALDEHYDE_DEHYDR_CYS UniProtKB/Swiss-Prot
  ALDEHYDE_DEHYDR_GLU UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000011497 RatGTEx
Superfamily-SCOP SSF53720 UniProtKB/Swiss-Prot
UniProt A6IJA2 ENTREZGENE, UniProtKB/TrEMBL
  AL1B1_RAT UniProtKB/Swiss-Prot
  G3V7I5 ENTREZGENE, UniProtKB/TrEMBL
  Q66HF8 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-12-06 Aldh1b1  aldehyde dehydrogenase 1 family, member B1  Aldh1b1_predicted  aldehyde dehydrogenase 1 family, member B1 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Aldh1b1_predicted  aldehyde dehydrogenase 1 family, member B1 (predicted)      Symbol and Name status set to approved 70820 APPROVED