Adgrf2 (adhesion G protein-coupled receptor F2) - Rat Genome Database

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Gene: Adgrf2 (adhesion G protein-coupled receptor F2) Rattus norvegicus
Analyze
Symbol: Adgrf2
Name: adhesion G protein-coupled receptor F2
RGD ID: 1306718
Description: Predicted to enable G protein-coupled receptor activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway. Predicted to be located in membrane. Orthologous to human ADGRF2P (adhesion G protein-coupled receptor F2, pseudogene); INTERACTS WITH bisphenol A; lead diacetate; trichloroethene.
Type: protein-coding
RefSeq Status: MODEL
Previously known as: adhesion G-protein coupled receptor F2; G protein-coupled receptor 111; G protein-coupled receptor 115; G-protein coupled receptor 111; G-protein coupled receptor PGR20; Gpr111; Gpr115; LOC301269; probable G-protein coupled receptor 111
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8925,735,607 - 25,745,962 (+)NCBIGRCr8
mRatBN7.2918,238,389 - 18,248,745 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl918,219,714 - 18,269,038 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0920,898,943 - 20,948,284 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl920,917,673 - 20,950,386 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0919,771,781 - 19,810,350 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4913,960,770 - 13,973,241 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1913,936,316 - 13,968,349 (+)NCBI
Celera915,923,302 - 15,971,903 (+)NCBICelera
Cytogenetic Map9q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
membrane  (IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. GOA pipeline RGD automated data pipeline
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Adgrf2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8925,735,607 - 25,745,962 (+)NCBIGRCr8
mRatBN7.2918,238,389 - 18,248,745 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl918,219,714 - 18,269,038 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0920,898,943 - 20,948,284 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl920,917,673 - 20,950,386 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0919,771,781 - 19,810,350 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4913,960,770 - 13,973,241 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1913,936,316 - 13,968,349 (+)NCBI
Celera915,923,302 - 15,971,903 (+)NCBICelera
Cytogenetic Map9q13NCBI
ADGRF2P
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38647,656,472 - 47,697,794 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl647,673,420 - 47,693,719 (+)EnsemblGRCh38hg38GRCh38
GRCh37647,624,208 - 47,665,530 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36647,732,285 - 47,766,296 (+)NCBINCBI36Build 36hg18NCBI36
Build 34647,732,181 - 47,758,379NCBI
Celera649,180,394 - 49,221,792 (+)NCBICelera
Cytogenetic Map6p12.3NCBI
HuRef647,352,079 - 47,393,449 (+)NCBIHuRef
CHM1_1647,627,133 - 47,668,488 (+)NCBICHM1_1
T2T-CHM13v2.0647,498,118 - 47,539,580 (+)NCBIT2T-CHM13v2.0
Adgrf2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391743,004,919 - 43,054,646 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1743,007,021 - 43,053,070 (-)EnsemblGRCm39 Ensembl
GRCm381742,694,028 - 42,743,753 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1742,696,130 - 42,742,179 (-)EnsemblGRCm38mm10GRCm38
GRCm38.p6 Ensembl1742,708,936 - 42,742,179 (-)EnsemblGRCm38mm10GRCm38
MGSCv371742,845,886 - 42,879,128 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361742,172,421 - 42,205,663 (-)NCBIMGSCv36mm8
Celera1746,129,553 - 46,162,658 (-)NCBICelera
Cytogenetic Map17B3NCBI
cM Map1719.66NCBI
Adgrf2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543712,095,601 - 12,126,710 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543712,104,938 - 12,126,649 (+)NCBIChiLan1.0ChiLan1.0
LOC100991737
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2562,169,248 - 62,189,580 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1658,018,353 - 58,060,742 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0647,239,514 - 47,279,734 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1648,502,919 - 48,529,581 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl648,502,919 - 48,537,453 (+)Ensemblpanpan1.1panPan2
ADGRF2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11215,716,866 - 15,739,690 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1215,701,981 - 15,735,213 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1215,733,024 - 15,770,650 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01216,204,945 - 16,242,393 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1216,204,948 - 16,240,571 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11215,714,103 - 15,751,846 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01215,806,684 - 15,844,322 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01215,954,135 - 15,991,995 (+)NCBIUU_Cfam_GSD_1.0
Adgrf2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494651,086,555 - 51,123,314 (+)NCBIHiC_Itri_2
SpeTri2.0NW_00493647612,836,901 - 12,857,743 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ADGRF4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl742,373,211 - 42,430,700 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1742,357,184 - 42,401,773 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2392,015,231 - 92,060,068 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ADGRF2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11724,595,746 - 24,632,284 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604447,671,850 - 47,721,653 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Adgrf2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475413,383,349 - 13,414,132 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Adgrf2
9 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:106
Count of miRNA genes:86
Interacting mature miRNAs:96
Transcripts:ENSRNOT00000033075
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70226Eae4Experimental allergic encephalomyelitis QTL 4nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)9125661317Rat
9589055Scfw5Subcutaneous fat weight QTL 55.550.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)9137999212Rat
7411592Foco8Food consumption QTL 87.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)9137999212Rat
9589158Gluco65Glucose level QTL 656.820.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)9137999212Rat
1300124Cm4Cardiac mass QTL 43.55heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)9140594091Rat
1298088Edpm11Estrogen-dependent pituitary mass QTL 112.5pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)9143718459Rat
1641911Alcrsp13Alcohol response QTL 13response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)9143718459Rat
10054125Srcrt7Stress Responsive Cort QTL 73.330.0011blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)9187073594Rat
1331757Cdexp1CD45RC expression in CD8 T cells QTL 14.3CD8-positive T cell quantity (VT:0008077)blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)9102453767509080Rat
1354650Despr5Despair related QTL 54.010.0017locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)9125408446254084Rat
2303559Gluco54Glucose level QTL 542blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)9125408446254084Rat
61425Cia15Collagen induced arthritis QTL 154.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)9510982642921101Rat
631211Bw4Body weight QTL45.31retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)9510982650109826Rat
11353947Bp392Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)9728325252283252Rat
61450Ciaa3CIA Autoantibody QTL 36.5blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)9795472022071169Rat
9589133Insul26Insulin level QTL 2617.960.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)9895256053952560Rat
7411609Foco16Food consumption QTL 1625.60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)9895256053952560Rat
1600365Mcs20Mammary carcinoma susceptibility QTL 203mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)91353377042791750Rat
724543Cm20Cardiac mass QTL 203.9heart mass (VT:0007028)calculated heart weight (CMO:0000073)91696139840594091Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium
Low 10 13 10 6 10 8
Below cutoff 3 12 17 11 6 11 8 9 44 23 11 3 8

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_001069077 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017596752 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017596753 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017596754 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017596755 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017596756 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017596757 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017596758 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017596759 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017603818 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017603819 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017603820 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017603821 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017603822 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017603823 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017603824 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017603825 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_236958 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide CH473987 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000009 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSRNOT00000033075   ⟹   ENSRNOP00000035606
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl918,219,714 - 18,269,038 (+)Ensembl
Rnor_6.0 Ensembl920,917,673 - 20,950,386 (+)Ensembl
RefSeq Acc Id: XM_017596752   ⟹   XP_017452241
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8925,735,607 - 25,745,962 (+)NCBI
mRatBN7.2918,238,389 - 18,248,745 (+)NCBI
Rnor_6.0920,917,433 - 20,948,284 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_017452241 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein D4A3T6 (Get FASTA)   NCBI Sequence Viewer  
  EDM18683 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000035606.6
RefSeq Acc Id: XP_017452241   ⟸   XM_017596752
- UniProtKB: A6JJ49 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000035606   ⟸   ENSRNOT00000033075
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A3T6-F1-model_v2 AlphaFold D4A3T6 1-638 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1306718 AgrOrtholog
BioCyc Gene G2FUF-28095 BioCyc
Ensembl Genes ENSRNOG00000025603 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000033075.6 UniProtKB/TrEMBL
Gene3D-CATH 2.60.220.50 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro GAIN_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_2-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_2_Ig-hepta-like_rcpt UniProtKB/TrEMBL
  GPCR_2_secretin-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 301269 ENTREZGENE
PANTHER ADHESION G-PROTEIN COUPLED RECEPTOR F2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR45813 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 7tm_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Adgrf2 PhenoGen
PRINTS GPCRSECRETIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IGHEPTARCPTR UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F2_4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000025603 RatGTEx
SMART GPS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0H2UHU8_RAT UniProtKB/TrEMBL
  A6JJ49 ENTREZGENE, UniProtKB/TrEMBL
  AGRF2_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-03-16 Adgrf2  adhesion G protein-coupled receptor F2  Gpr111  G protein-coupled receptor 111  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-04 Gpr111  G protein-coupled receptor 111  Gpr115_predicted  G protein-coupled receptor 115 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-12 Gpr115_predicted  G protein-coupled receptor 115 (predicted)      Symbol and Name status set to approved 70820 APPROVED