Etv4 (ETS variant transcription factor 4) - Rat Genome Database

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Gene: Etv4 (ETS variant transcription factor 4) Rattus norvegicus
Analyze
Symbol: Etv4
Name: ETS variant transcription factor 4
RGD ID: 1306524
Description: Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in cell differentiation; positive regulation of keratinocyte differentiation; and regulation of gene expression. Predicted to act upstream of or within several processes, including branching involved in mammary gland duct morphogenesis; motor neuron axon guidance; and negative regulation of mammary gland epithelial cell proliferation. Predicted to be located in chromosome and nucleolus. Predicted to be active in nucleus. Orthologous to human ETV4 (ETS variant transcription factor 4); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; acetamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: ETS translocation variant 4; ets variant 4; ets variant gene 4 (E1A enhancer binding protein, E1AF); Pea3; polyomavirus enhancer activator-3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21086,706,749 - 86,721,974 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1086,706,749 - 86,721,974 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1091,741,654 - 91,757,041 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01091,217,278 - 91,232,667 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01086,610,569 - 86,625,960 (-)NCBIRnor_WKY
Rnor_6.01089,685,058 - 89,700,300 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1089,685,058 - 89,700,283 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01089,481,284 - 89,496,509 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41090,808,439 - 90,824,019 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11090,823,391 - 90,918,794 (-)NCBI
Celera1085,428,244 - 85,443,438 (-)NCBICelera
Cytogenetic Map10q32.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-hydroxypropanoic acid  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-Nitrobenzanthrone  (ISO)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
acetaldehyde  (ISO)
acetamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsenous acid  (ISO)
avobenzone  (ISO)
benzo[a]pyrene  (ISO)
benzoates  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bortezomib  (ISO)
C60 fullerene  (EXP)
caffeine  (ISO)
calciol  (ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
chloroprene  (EXP)
chromium(6+)  (ISO)
cisplatin  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
cyproconazole  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP,ISO)
dicrotophos  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
ethanol  (ISO)
flusilazole  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
furan  (EXP)
hexaconazole  (ISO)
hydroquinone  (ISO)
kahweol  (ISO)
leflunomide  (ISO)
lipopolysaccharide  (ISO)
manganese(II) chloride  (EXP)
mercury dichloride  (EXP)
methotrexate  (ISO)
methylmercury chloride  (EXP,ISO)
mibolerone  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodiethylamine  (ISO)
orlistat  (ISO)
ozone  (ISO)
paracetamol  (ISO)
PD 0325901  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctanoic acid  (ISO)
Phenylamil  (ISO)
potassium chromate  (ISO)
quercetin  (ISO)
quinolin-8-ol  (ISO)
quinomethionate  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sotorasib  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
tert-butyl hydroperoxide  (ISO)
thapsigargin  (ISO)
thioacetamide  (EXP)
trametinib  (ISO)
trimellitic anhydride  (ISO)
triptonide  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vanadium atom  (ISO)
vanadium(0)  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
chromosome  (IEA,ISO)
nucleolus  (IEA)
nucleolus  (ISO)
nucleolus  (ISO)
nucleus  (IBA,ISO)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10482234   PMID:12372283   PMID:12477932   PMID:12527199   PMID:12855694   PMID:12871699   PMID:14625302   PMID:15253939   PMID:15466854   PMID:16394217   PMID:18977342   PMID:19293599  
PMID:22014525   PMID:24089499   PMID:24983502   PMID:25512490   PMID:27909004   PMID:32891673  


Genomics

Comparative Map Data
Etv4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21086,706,749 - 86,721,974 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1086,706,749 - 86,721,974 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1091,741,654 - 91,757,041 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01091,217,278 - 91,232,667 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01086,610,569 - 86,625,960 (-)NCBIRnor_WKY
Rnor_6.01089,685,058 - 89,700,300 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1089,685,058 - 89,700,283 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01089,481,284 - 89,496,509 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41090,808,439 - 90,824,019 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11090,823,391 - 90,918,794 (-)NCBI
Celera1085,428,244 - 85,443,438 (-)NCBICelera
Cytogenetic Map10q32.1NCBI
ETV4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381743,527,846 - 43,546,340 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1743,527,844 - 43,579,620 (-)EnsemblGRCh38hg38GRCh38
GRCh371741,605,214 - 41,623,708 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361738,960,737 - 38,979,288 (-)NCBINCBI36Build 36hg18NCBI36
Build 341738,960,740 - 38,978,773NCBI
Celera1738,314,866 - 38,333,417 (-)NCBICelera
Cytogenetic Map17q21.31NCBI
HuRef1737,370,108 - 37,388,652 (-)NCBIHuRef
CHM1_11741,840,934 - 41,859,527 (-)NCBICHM1_1
T2T-CHM13v2.01744,380,321 - 44,398,821 (-)NCBIT2T-CHM13v2.0
Etv4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911101,660,573 - 101,677,963 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11101,660,568 - 101,676,197 (-)EnsemblGRCm39 Ensembl
GRCm3811101,769,747 - 101,785,310 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11101,769,742 - 101,785,371 (-)EnsemblGRCm38mm10GRCm38
MGSCv3711101,631,056 - 101,646,624 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611101,585,841 - 101,601,353 (-)NCBIMGSCv36mm8
Celera11113,471,367 - 113,487,011 (-)NCBICelera
Cytogenetic Map11DNCBI
cM Map1165.48NCBI
Etv4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545116,965,125 - 16,976,127 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545116,965,404 - 16,976,503 (-)NCBIChiLan1.0ChiLan1.0
ETV4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11714,099,908 - 14,116,186 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1714,099,160 - 14,116,186 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01713,850,823 - 13,869,347 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
ETV4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1919,715,259 - 19,731,085 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl919,715,535 - 19,730,456 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha919,104,222 - 19,119,467 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0920,410,313 - 20,425,587 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl920,410,648 - 20,425,573 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1919,263,277 - 19,278,546 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0919,445,948 - 19,461,216 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0919,591,463 - 19,606,744 (+)NCBIUU_Cfam_GSD_1.0
Etv4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560219,055,407 - 19,071,438 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936541123,049 - 139,256 (-)EnsemblSpeTri2.0
SpeTri2.0NW_004936541120,533 - 138,463 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ETV4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1219,531,603 - 19,548,301 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11219,531,507 - 19,548,303 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21219,893,682 - 19,910,632 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ETV4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11662,864,628 - 62,883,574 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1662,865,275 - 62,883,563 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607733,629,816 - 33,648,805 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Etv4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247951,079,537 - 1,089,964 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247951,079,024 - 1,090,364 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Etv4
57 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:109
Count of miRNA genes:76
Interacting mature miRNAs:89
Transcripts:ENSRNOT00000028213
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101448701189062041Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
1554317Bmd4Bone mineral density QTL 49.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)101981604299406971Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102242750090627625Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102652195798952741Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040035094102359817Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042045676104670812Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)14232313287323132Rat
70198BpQTLcluster9Blood pressure QTL cluster 92.94arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)104232313287323132Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104444169989441699Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104444169989441699Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104444169989441699Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104502965095600334Rat
631547Bp87Blood pressure QTL 874.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104736947092369470Rat
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105057470795574707Rat
70364Bp72Blood pressure QTL 72arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105112110096121100Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1051770177107211142Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1051770177107211142Rat
1359017Hrtrt21Heart rate QTL 212.4heart pumping trait (VT:2000009)heart rate (CMO:0000002)105177294096772940Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)105177461295600334Rat
631535Cm51Cardiac mass QTL 513heart mass (VT:0007028)calculated heart weight (CMO:0000073)105178628291669536Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1053797385107211142Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105379749498952626Rat
1354608Cm33Cardiac mass QTL 332.8heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)105480929299809292Rat
2312662Slep8Serum leptin concentration QTL 80.05blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1057134272102134272Rat
2312668Scl65Serum cholesterol level QTL 650.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1057134272102134272Rat
2312672Insul15Insulin level QTL 150.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1057134272102134272Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1057576521102576521Rat
2293698Bss43Bone structure and strength QTL 435.330.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1059209888104209888Rat
2306970Anxrr22Anxiety related response QTL 225.95fear/anxiety-related behavior trait (VT:1000241)number of periods of voluntary immobility (CMO:0001045)106134527698211570Rat
6893336Cm75Cardiac mass QTL 750.10.87heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)106134527699703528Rat
1558643Cm44Cardiac mass QTL 444.80.0000368heart mass (VT:0007028)heart wet weight (CMO:0000069)106134527699703528Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062057807107057807Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062057807107057807Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063221094107211142Rat
1357344Bp249Blood pressure QTL 2490.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)106674365598003205Rat
2317029Aia19Adjuvant induced arthritis QTL 192.98joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)1066978955107211142Rat
2317039Aia6Adjuvant induced arthritis QTL 64.31joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)1066978955107211142Rat
10450498Bp384Blood pressure QTL 3840.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1067750049107211142Rat
1642980Bp300Blood pressure QTL 300arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068383129107211142Rat
61396Bp9Blood pressure QTL 94.80.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068420376107211142Rat
2300172Bmd57Bone mineral density QTL 579.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1069738412107211142Rat
2293646Bss25Bone structure and strength QTL 2510.960.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1069738412107211142Rat
2293663Bss33Bone structure and strength QTL 339.340.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1069738412107211142Rat
6893366Bw106Body weight QTL 1060.30.47body mass (VT:0001259)body weight (CMO:0000012)1070199100107211142Rat
70193Mcs7Mammary carcinoma susceptibility QTL 72.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072224939107211142Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1072224939107211142Rat
2306793Ean5Experimental allergic neuritis QTL 54.7nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)107255241693995749Rat
1358188Ept9Estrogen-induced pituitary tumorigenesis QTL 93.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107345313696120911Rat
2292617Ept18Estrogen-induced pituitary tumorigenesis QTL 183.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107345313696120911Rat
1579919Bp281Blood pressure QTL 2810.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107437208494965338Rat
631537Oia4Oil induced arthritis QTL 4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)107563188787055282Rat
10450495Bp383Blood pressure QTL 3830.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107624608594965338Rat
2292438Bp311Blood pressure QTL 311arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1076246085107211142Rat
1302404Cia27Collagen induced arthritis QTL 272.60.0045joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)1076452683107211142Rat
4889492Pancm2Pancreatic morphology QTL 23.2pancreatic beta cell morphology trait (VT:0005217)ratio of insulin-positive cell area to total area of splenic region of pancreas (CMO:0001814)1076748906107211142Rat
1300107Rf18Renal function QTL 183.41urine output (VT:0003620)timed urine volume (CMO:0000260)107877551698279596Rat
1358915Stresp7Stress response QTL 73.52blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)107889965587307728Rat
631555Bp134Blood pressure QTL 1340.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)108051528791230079Rat
6893357Bw102Body weight QTL 1020.50.36body mass (VT:0001259)body weight (CMO:0000012)1080515287101325465Rat
2303589Bw87Body weight QTL 872body mass (VT:0001259)body weight (CMO:0000012)1081285008107211142Rat
4889948Bss91Bone structure and strength QTL 914tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)108256485692369470Rat
2317754Glom25Glomerulus QTL 253.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)1082685200107211142Rat
12880055Am11Aortic mass QTL 110.004aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)108400727295933025Rat
2301398Kidm38Kidney mass QTL 380.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)108400727295933025Rat
2306792Ean4Experimental allergic neuritis QTL 44nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)108402232193995963Rat
1600367Mcs15Mammary carcinoma susceptibility QTL 154.5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1085565469103884409Rat

Markers in Region
X63190  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21086,707,132 - 86,707,264 (+)MAPPERmRatBN7.2
Rnor_6.01089,685,442 - 89,685,573NCBIRnor6.0
Rnor_5.01089,481,668 - 89,481,799UniSTSRnor5.0
RGSC_v3.41090,808,823 - 90,808,954UniSTSRGSC3.4
Celera1085,428,628 - 85,428,759UniSTS
Cytogenetic Map10q32.1UniSTS
RH132517  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21086,706,770 - 86,706,985 (+)MAPPERmRatBN7.2
Rnor_6.01089,685,080 - 89,685,294NCBIRnor6.0
Rnor_5.01089,481,306 - 89,481,520UniSTSRnor5.0
RGSC_v3.41090,808,461 - 90,808,675UniSTSRGSC3.4
Celera1085,428,266 - 85,428,480UniSTS
Cytogenetic Map10q32.1UniSTS
RH142884  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21086,710,111 - 86,710,402 (+)MAPPERmRatBN7.2
Rnor_6.01089,688,421 - 89,688,711NCBIRnor6.0
Rnor_5.01089,484,647 - 89,484,937UniSTSRnor5.0
RGSC_v3.41090,811,802 - 90,812,092UniSTSRGSC3.4
Celera1085,431,607 - 85,431,897UniSTS
RH 3.4 Map10886.9UniSTS
Cytogenetic Map10q32.1UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 14 35 16 23 7
Low 3 23 18 10 7 10 8 11 39 14 17 4 8
Below cutoff 6 36 28 12 28 5 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000028213   ⟹   ENSRNOP00000028213
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1086,706,749 - 86,721,974 (-)Ensembl
Rnor_6.0 Ensembl1089,685,058 - 89,700,283 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000084311   ⟹   ENSRNOP00000070185
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1086,706,754 - 86,721,527 (-)Ensembl
Rnor_6.0 Ensembl1089,685,063 - 89,699,836 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000105588   ⟹   ENSRNOP00000096295
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1086,706,749 - 86,718,848 (-)Ensembl
RefSeq Acc Id: NM_001108299   ⟹   NP_001101769
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21086,706,749 - 86,721,974 (-)NCBI
Rnor_6.01089,685,058 - 89,700,283 (-)NCBI
Rnor_5.01089,481,284 - 89,496,509 (-)NCBI
RGSC_v3.41090,808,439 - 90,824,019 (-)RGD
Celera1085,428,244 - 85,443,438 (-)RGD
Sequence:
RefSeq Acc Id: XM_006247369   ⟹   XP_006247431
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21086,706,750 - 86,721,967 (-)NCBI
Rnor_6.01089,685,060 - 89,700,298 (-)NCBI
Rnor_5.01089,481,284 - 89,496,509 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006247370   ⟹   XP_006247432
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21086,707,349 - 86,721,598 (-)NCBI
Rnor_6.01089,685,060 - 89,699,944 (-)NCBI
Rnor_5.01089,481,284 - 89,496,509 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006247371   ⟹   XP_006247433
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21086,706,754 - 86,721,603 (-)NCBI
Rnor_6.01089,685,060 - 89,699,944 (-)NCBI
Rnor_5.01089,481,284 - 89,496,509 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006247372   ⟹   XP_006247434
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21086,707,349 - 86,721,955 (-)NCBI
Rnor_6.01089,685,060 - 89,700,298 (-)NCBI
Rnor_5.01089,481,284 - 89,496,509 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008768085   ⟹   XP_008766307
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21086,707,349 - 86,721,967 (-)NCBI
Rnor_6.01089,685,060 - 89,700,297 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008768086   ⟹   XP_008766308
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21086,706,756 - 86,721,968 (-)NCBI
Rnor_6.01089,685,060 - 89,700,300 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017597400   ⟹   XP_017452889
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21086,706,756 - 86,721,967 (-)NCBI
Rnor_6.01089,685,060 - 89,700,299 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039086407   ⟹   XP_038942335
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21086,707,349 - 86,721,603 (-)NCBI
RefSeq Acc Id: XM_039086408   ⟹   XP_038942336
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21086,706,754 - 86,721,897 (-)NCBI
RefSeq Acc Id: XM_039086409   ⟹   XP_038942337
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21086,707,349 - 86,721,954 (-)NCBI
RefSeq Acc Id: XM_039086410   ⟹   XP_038942338
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21086,707,349 - 86,718,714 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_001101769   ⟸   NM_001108299
- UniProtKB: E9PTJ2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006247434   ⟸   XM_006247372
- Peptide Label: isoform X5
- UniProtKB: A0A0G2JX95 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006247431   ⟸   XM_006247369
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006247433   ⟸   XM_006247371
- Peptide Label: isoform X5
- UniProtKB: A0A0G2JX95 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006247432   ⟸   XM_006247370
- Peptide Label: isoform X5
- UniProtKB: A0A0G2JX95 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008766308   ⟸   XM_008768086
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_008766307   ⟸   XM_008768085
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_017452889   ⟸   XM_017597400
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: ENSRNOP00000028213   ⟸   ENSRNOT00000028213
RefSeq Acc Id: ENSRNOP00000070185   ⟸   ENSRNOT00000084311
RefSeq Acc Id: XP_038942336   ⟸   XM_039086408
- Peptide Label: isoform X7
RefSeq Acc Id: XP_038942337   ⟸   XM_039086409
- Peptide Label: isoform X8
RefSeq Acc Id: XP_038942335   ⟸   XM_039086407
- Peptide Label: isoform X6
- UniProtKB: E9PTJ2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038942338   ⟸   XM_039086410
- Peptide Label: isoform X9
- UniProtKB: A0A8I6AQD4 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000096295   ⟸   ENSRNOT00000105588
Protein Domains
ETS

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2JX95-F1-model_v2 AlphaFold A0A0G2JX95 1-487 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697769
Promoter ID:EPDNEW_R8293
Type:single initiation site
Name:Etv4_1
Description:ets variant 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01089,700,225 - 89,700,285EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1306524 AgrOrtholog
BioCyc Gene G2FUF-23147 BioCyc
Ensembl Genes ENSRNOG00000020792 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000028213 ENTREZGENE
  ENSRNOP00000028213.4 UniProtKB/TrEMBL
  ENSRNOP00000070185 ENTREZGENE
  ENSRNOP00000070185.2 UniProtKB/TrEMBL
  ENSRNOP00000096295 ENTREZGENE
  ENSRNOP00000096295.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000028213 ENTREZGENE
  ENSRNOT00000028213.7 UniProtKB/TrEMBL
  ENSRNOT00000084311 ENTREZGENE
  ENSRNOT00000084311.2 UniProtKB/TrEMBL
  ENSRNOT00000105588 ENTREZGENE
  ENSRNOT00000105588.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.10.10 UniProtKB/TrEMBL
InterPro Ets_dom UniProtKB/TrEMBL
  ETS_fam UniProtKB/TrEMBL
  ETS_PEA3_N UniProtKB/TrEMBL
  WH-like_DNA-bd_sf UniProtKB/TrEMBL
  WH_DNA-bd_sf UniProtKB/TrEMBL
KEGG Report rno:360635 UniProtKB/TrEMBL
NCBI Gene 360635 ENTREZGENE
PANTHER ETS TRANSLOCATION VARIANT 4 UniProtKB/TrEMBL
  PTHR11849 UniProtKB/TrEMBL
Pfam Ets UniProtKB/TrEMBL
  ETS_PEA3_N UniProtKB/TrEMBL
PhenoGen Etv4 PhenoGen
PRINTS ETSDOMAIN UniProtKB/TrEMBL
PROSITE ETS_DOMAIN_1 UniProtKB/TrEMBL
  ETS_DOMAIN_2 UniProtKB/TrEMBL
  ETS_DOMAIN_3 UniProtKB/TrEMBL
SMART ETS UniProtKB/TrEMBL
Superfamily-SCOP SSF46785 UniProtKB/TrEMBL
UniProt A0A0G2JX95 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AQD4 ENTREZGENE, UniProtKB/TrEMBL
  B5DF72_RAT UniProtKB/TrEMBL
  E9PTJ2 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-08-29 Etv4  ETS variant transcription factor 4  Etv4  ets variant 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-10-23 Etv4  ets variant 4  Etv4  ets variant gene 4 (E1A enhancer binding protein, E1AF)   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Etv4  ets variant gene 4 (E1A enhancer binding protein, E1AF)   Etv4_predicted  ets variant gene 4 (E1A enhancer binding protein, E1AF) (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Etv4_predicted  ets variant gene 4 (E1A enhancer binding protein, E1AF) (predicted)      Symbol and Name status set to approved 70820 APPROVED