Etv4 (ETS variant transcription factor 4) - Rat Genome Database

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Gene: Etv4 (ETS variant transcription factor 4) Rattus norvegicus
Analyze
Symbol: Etv4
Name: ETS variant transcription factor 4
RGD ID: 1306524
Description: Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in cell differentiation; positive regulation of keratinocyte differentiation; and regulation of gene expression. Predicted to act upstream of or within several processes, including branching involved in mammary gland duct morphogenesis; motor neuron axon guidance; and negative regulation of mammary gland epithelial cell proliferation. Predicted to be located in chromosome and nucleolus. Predicted to be active in nucleus. Orthologous to human ETV4 (ETS variant transcription factor 4); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; acetamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: ETS translocation variant 4; ets variant 4; ets variant gene 4 (E1A enhancer binding protein, E1AF); Pea3; polyomavirus enhancer activator-3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81087,206,977 - 87,222,202 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1087,206,977 - 87,222,318 (-)EnsemblGRCr8
mRatBN7.21086,706,749 - 86,721,974 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1086,706,749 - 86,721,974 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1091,741,654 - 91,757,041 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01091,217,278 - 91,232,667 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01086,610,569 - 86,625,960 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01089,685,058 - 89,700,300 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1089,685,058 - 89,700,283 (-)Ensemblrn6Rnor6.0
Rnor_5.01089,481,284 - 89,496,509 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41090,808,439 - 90,824,019 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1085,428,244 - 85,443,438 (-)NCBICelera
RGSC_v3.11090,823,391 - 90,918,794 (-)NCBI
Cytogenetic Map10q32.1NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-hydroxypropanoic acid  (ISO)
2-palmitoylglycerol  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-Nitrobenzanthrone  (ISO)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
acetaldehyde  (ISO)
acetamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsenous acid  (ISO)
atrazine  (EXP)
avobenzone  (ISO)
benzene-1,2,4-triol  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzoates  (ISO)
beta-lapachone  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bortezomib  (ISO)
C60 fullerene  (EXP)
cadmium dichloride  (ISO)
caffeine  (ISO)
calciol  (ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
chloroprene  (EXP)
chlorpyrifos  (ISO)
chromium(6+)  (ISO)
cisplatin  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
cyproconazole  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP,ISO)
dicrotophos  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
ethanol  (ISO)
flusilazole  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
furan  (EXP)
hexaconazole  (ISO)
hydroquinone  (ISO)
kahweol  (ISO)
lead diacetate  (ISO)
lead(0)  (ISO)
leflunomide  (ISO)
lipopolysaccharide  (ISO)
manganese(II) chloride  (EXP)
mercury dichloride  (EXP)
methotrexate  (ISO)
methylmercury chloride  (EXP,ISO)
mibolerone  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodiethylamine  (ISO)
okadaic acid  (ISO)
orlistat  (ISO)
ozone  (ISO)
paracetamol  (ISO)
PD 0325901  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
Phenylamil  (ISO)
potassium chromate  (ISO)
quercetin  (ISO)
quinolin-8-ol  (ISO)
quinomethionate  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sotorasib  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
tert-butyl hydroperoxide  (ISO)
thapsigargin  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
trametinib  (ISO)
trimellitic anhydride  (ISO)
triptonide  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vanadium atom  (ISO)
vanadium(0)  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
chromosome  (IEA,ISO)
nucleolus  (IEA,ISO)
nucleus  (IBA,IEA,ISO)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10482234   PMID:12372283   PMID:12477932   PMID:12527199   PMID:12855694   PMID:12871699   PMID:14625302   PMID:15253939   PMID:15466854   PMID:16394217   PMID:18977342   PMID:19293599  
PMID:22014525   PMID:24089499   PMID:24983502   PMID:25512490   PMID:27909004   PMID:32891673  


Genomics

Comparative Map Data
Etv4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81087,206,977 - 87,222,202 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1087,206,977 - 87,222,318 (-)EnsemblGRCr8
mRatBN7.21086,706,749 - 86,721,974 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1086,706,749 - 86,721,974 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1091,741,654 - 91,757,041 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01091,217,278 - 91,232,667 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01086,610,569 - 86,625,960 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01089,685,058 - 89,700,300 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1089,685,058 - 89,700,283 (-)Ensemblrn6Rnor6.0
Rnor_5.01089,481,284 - 89,496,509 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41090,808,439 - 90,824,019 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1085,428,244 - 85,443,438 (-)NCBICelera
RGSC_v3.11090,823,391 - 90,918,794 (-)NCBI
Cytogenetic Map10q32.1NCBI
ETV4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381743,527,846 - 43,546,340 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1743,527,844 - 43,579,620 (-)Ensemblhg38GRCh38
GRCh371741,605,214 - 41,623,708 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361738,960,737 - 38,979,288 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341738,960,740 - 38,978,773NCBI
Celera1738,314,866 - 38,333,417 (-)NCBICelera
Cytogenetic Map17q21.31NCBI
HuRef1737,370,108 - 37,388,652 (-)NCBIHuRef
CHM1_11741,840,934 - 41,859,527 (-)NCBICHM1_1
T2T-CHM13v2.01744,380,321 - 44,398,821 (-)NCBIT2T-CHM13v2.0
Etv4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911101,660,573 - 101,677,963 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11101,660,568 - 101,676,197 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm3811101,769,747 - 101,785,310 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11101,769,742 - 101,785,371 (-)Ensemblmm10GRCm38
MGSCv3711101,631,056 - 101,646,624 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3611101,585,841 - 101,601,353 (-)NCBIMGSCv36mm8
Celera11113,471,367 - 113,487,011 (-)NCBICelera
Cytogenetic Map11DNCBI
cM Map1165.48NCBI
Etv4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545116,965,125 - 16,976,127 (-)Ensembl
ChiLan1.0NW_00495545116,965,404 - 16,976,503 (-)NCBIChiLan1.0ChiLan1.0
ETV4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21921,361,475 - 21,380,028 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11723,325,853 - 23,344,363 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01713,850,823 - 13,869,347 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11714,099,908 - 14,116,186 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1714,099,160 - 14,116,186 (+)EnsemblpanPan2panpan1.1
ETV4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1919,715,259 - 19,731,085 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl919,715,535 - 19,730,456 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha919,104,222 - 19,119,467 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0920,410,313 - 20,425,587 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl920,410,648 - 20,425,573 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1919,263,277 - 19,278,546 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0919,445,948 - 19,461,216 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0919,591,463 - 19,606,744 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Etv4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560219,055,407 - 19,071,438 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936541123,049 - 139,256 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936541120,533 - 138,463 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ETV4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1219,531,603 - 19,548,301 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11219,531,507 - 19,548,303 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21219,893,682 - 19,910,632 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ETV4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11662,864,628 - 62,883,574 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1662,865,275 - 62,883,563 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366607733,629,816 - 33,648,805 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Etv4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247951,079,537 - 1,089,964 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247951,079,024 - 1,090,364 (+)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Etv4
46 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:109
Count of miRNA genes:76
Interacting mature miRNAs:89
Transcripts:ENSRNOT00000028213
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105107189796071897Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102702353598502431Rat
8657410Bp374Blood pressure QTL 374heart left ventricle size trait (VT:0002753)heart left ventricle end-diastolic diameter (CMO:0000982)1067476608107713808Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063719161107713808Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)103550938391417879Rat
631555Bp134Blood pressure QTL 1340.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)108101207791729860Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042546145107713808Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1058073360103073360Rat
12903252Cm113Cardiac mass QTL 1130.047heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)1066817119107713808Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105429633699451733Rat
4889948Bss91Bone structure and strength QTL 914tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)108306123692869129Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1064939013107713808Rat
1302404Cia27Collagen induced arthritis QTL 272.60.0045joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)1076951790107713808Rat
1579919Bp281Blood pressure QTL 2810.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105046480295464802Rat
1300107Rf18Renal function QTL 183.41urine output (VT:0003620)timed urine volume (CMO:0000260)1079272424102982300Rat
70168Eae12Experimental allergic encephalomyelitis QTL 120.0009nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)1073599825107713808Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104552916496099749Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104493935989939359Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1054296227107713808Rat
10450495Bp383Blood pressure QTL 3830.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107674313395464802Rat
12903269Am15Aortic mass QTL 150.042aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1066817119107713808Rat
10450493Bp382Blood pressure QTL 3820.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105086028895860288Rat
12903266Cm114Cardiac mass QTL 1140.02heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)1066817119107713808Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2292617Ept18Estrogen-induced pituitary tumorigenesis QTL 183.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107395035396620293Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062556066107556066Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)14282327487823274Rat
70193Mcs7Mammary carcinoma susceptibility QTL 72.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072724423107713808Rat
12880372Am12Aortic mass QTL 120.003aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1066817119107713808Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062556066107556066Rat
12880375Kidm66Kidney mass QTL 660.009kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1066817119107713808Rat
1357344Bp249Blood pressure QTL 2490.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)106724133498502431Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104493935989939359Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014991535107556066Rat
12880370Cm105Cardiac mass QTL 1050.008heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)1066817119107713808Rat
70198BpQTLcluster9Blood pressure QTL cluster 92.94arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)104282327487823274Rat
12880371Cm106Cardiac mass QTL 1060.007heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)1066817119107713808Rat
2306970Anxrr22Anxiety related response QTL 225.95fear/anxiety-related behavior trait (VT:1000241)number of periods of voluntary immobility (CMO:0001045)106184349698710773Rat
1359017Hrtrt21Heart rate QTL 212.4heart pumping trait (VT:2000009)heart rate (CMO:0000002)107369533997272278Rat
11565453Kidm58Kidney mass QTL 580.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1066817119107713808Rat
7387312Bw125Body weight QTL 12530.0047retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight (CMO:0000356)1065390777107713808Rat
6893357Bw102Body weight QTL 1020.50.36body mass (VT:0001259)body weight (CMO:0000012)1081012077101828297Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102293137391127454Rat
2306793Ean5Experimental allergic neuritis QTL 54.7nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)107304965694495280Rat
2306792Ean4Experimental allergic neuritis QTL 44nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)104949549294495492Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1052269185107713808Rat
61396Bp9Blood pressure QTL 94.80.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068920187107713808Rat
1358915Stresp7Stress response QTL 73.52blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)1065307813107713808Rat
70363Bp71Blood pressure QTL 710.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1061843496106843496Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)102980091091417879Rat
6893366Bw106Body weight QTL 1060.30.47body mass (VT:0001259)body weight (CMO:0000012)1070698731107713808Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)102758722696099902Rat
1354608Cm33Cardiac mass QTL 332.8heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)105530797293608131Rat
1558643Cm44Cardiac mass QTL 444.80.0000368heart mass (VT:0007028)heart wet weight (CMO:0000069)1061843496100198886Rat
8552805Bw145Body weight QTL 1452.2body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)104360879388608793Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040535708107713808Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014991535107713808Rat
7207811Bmd90Bone mineral density QTL 905.2femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)104994371094943710Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
1581559Eae18Experimental allergic encephalomyelitis QTL 180.00002nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1066108888107555881Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104493935989939359Rat
6893336Cm75Cardiac mass QTL 750.10.87heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)1061843496100198886Rat
631547Bp87Blood pressure QTL 874.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104786912992869129Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10686461896620484Rat
12880055Am11Aortic mass QTL 110.004aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)108450348796432422Rat
2292438Bp311Blood pressure QTL 311arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107674313395604677Rat
2301398Kidm38Kidney mass QTL 380.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)108450348796432422Rat
2292436Bp310Blood pressure QTL 310arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105060467795604677Rat
1600367Mcs15Mammary carcinoma susceptibility QTL 154.5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072724423107713808Rat
6893342Cm78Cardiac mass QTL 780.10.88heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)103550938388177745Rat
631537Oia4Oil induced arthritis QTL 4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1076128947107713808Rat
1358188Ept9Estrogen-induced pituitary tumorigenesis QTL 93.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107395035396620293Rat
634354Rends3Renal damage susceptibility QTL 30.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)1061997479106997479Rat
2301405Cm69Cardiac mass QTL 690.031heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)1066817119107713808Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102702353599451848Rat

Markers in Region
X63190  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21086,707,132 - 86,707,264 (+)MAPPERmRatBN7.2
Rnor_6.01089,685,442 - 89,685,573NCBIRnor6.0
Rnor_5.01089,481,668 - 89,481,799UniSTSRnor5.0
RGSC_v3.41090,808,823 - 90,808,954UniSTSRGSC3.4
Celera1085,428,628 - 85,428,759UniSTS
Cytogenetic Map10q32.1UniSTS
RH132517  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21086,706,770 - 86,706,985 (+)MAPPERmRatBN7.2
Rnor_6.01089,685,080 - 89,685,294NCBIRnor6.0
Rnor_5.01089,481,306 - 89,481,520UniSTSRnor5.0
RGSC_v3.41090,808,461 - 90,808,675UniSTSRGSC3.4
Celera1085,428,266 - 85,428,480UniSTS
Cytogenetic Map10q32.1UniSTS
RH142884  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21086,710,111 - 86,710,402 (+)MAPPERmRatBN7.2
Rnor_6.01089,688,421 - 89,688,711NCBIRnor6.0
Rnor_5.01089,484,647 - 89,484,937UniSTSRnor5.0
RGSC_v3.41090,811,802 - 90,812,092UniSTSRGSC3.4
Celera1085,431,607 - 85,431,897UniSTS
RH 3.4 Map10886.9UniSTS
Cytogenetic Map10q32.1UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 11 67 157 88 87 56 57 56 6 314 156 9 135 78 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000028213   ⟹   ENSRNOP00000028213
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1087,206,977 - 87,222,318 (-)Ensembl
mRatBN7.2 Ensembl1086,706,749 - 86,721,974 (-)Ensembl
Rnor_6.0 Ensembl1089,685,058 - 89,700,283 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000084311   ⟹   ENSRNOP00000070185
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1087,206,982 - 87,221,755 (-)Ensembl
mRatBN7.2 Ensembl1086,706,754 - 86,721,527 (-)Ensembl
Rnor_6.0 Ensembl1089,685,063 - 89,699,836 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000105588   ⟹   ENSRNOP00000096295
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1087,206,977 - 87,222,017 (-)Ensembl
mRatBN7.2 Ensembl1086,706,749 - 86,718,848 (-)Ensembl
RefSeq Acc Id: NM_001108299   ⟹   NP_001101769
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81087,206,977 - 87,222,202 (-)NCBI
mRatBN7.21086,706,749 - 86,721,974 (-)NCBI
Rnor_6.01089,685,058 - 89,700,283 (-)NCBI
Rnor_5.01089,481,284 - 89,496,509 (-)NCBI
RGSC_v3.41090,808,439 - 90,824,019 (-)RGD
Celera1085,428,244 - 85,443,438 (-)RGD
Sequence:
RefSeq Acc Id: XM_006247369   ⟹   XP_006247431
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81087,206,978 - 87,222,196 (-)NCBI
mRatBN7.21086,706,750 - 86,721,967 (-)NCBI
Rnor_6.01089,685,060 - 89,700,298 (-)NCBI
Rnor_5.01089,481,284 - 89,496,509 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006247370   ⟹   XP_006247432
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81087,206,978 - 87,221,806 (-)NCBI
mRatBN7.21086,707,349 - 86,721,598 (-)NCBI
Rnor_6.01089,685,060 - 89,699,944 (-)NCBI
Rnor_5.01089,481,284 - 89,496,509 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006247371   ⟹   XP_006247433
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81087,206,978 - 87,221,823 (-)NCBI
mRatBN7.21086,706,754 - 86,721,603 (-)NCBI
Rnor_6.01089,685,060 - 89,699,944 (-)NCBI
Rnor_5.01089,481,284 - 89,496,509 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006247372   ⟹   XP_006247434
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81087,206,978 - 87,222,192 (-)NCBI
mRatBN7.21086,707,349 - 86,721,955 (-)NCBI
Rnor_6.01089,685,060 - 89,700,298 (-)NCBI
Rnor_5.01089,481,284 - 89,496,509 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008768086   ⟹   XP_008766308
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81087,206,978 - 87,222,197 (-)NCBI
mRatBN7.21086,706,756 - 86,721,968 (-)NCBI
Rnor_6.01089,685,060 - 89,700,300 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017597400   ⟹   XP_017452889
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81087,206,978 - 87,221,730 (-)NCBI
mRatBN7.21086,706,756 - 86,721,967 (-)NCBI
Rnor_6.01089,685,060 - 89,700,299 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039086407   ⟹   XP_038942335
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81087,206,978 - 87,221,823 (-)NCBI
mRatBN7.21086,707,349 - 86,721,603 (-)NCBI
RefSeq Acc Id: XM_039086410   ⟹   XP_038942338
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81087,206,978 - 87,218,941 (-)NCBI
mRatBN7.21086,707,349 - 86,718,714 (-)NCBI
RefSeq Acc Id: XM_063269443   ⟹   XP_063125513
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81087,206,978 - 87,221,824 (-)NCBI
RefSeq Acc Id: XM_063269444   ⟹   XP_063125514
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81087,206,978 - 87,221,350 (-)NCBI
RefSeq Acc Id: NP_001101769   ⟸   NM_001108299
- UniProtKB: E9PTJ2 (UniProtKB/TrEMBL),   A6HJF1 (UniProtKB/TrEMBL),   B5DF72 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006247434   ⟸   XM_006247372
- Peptide Label: isoform X4
- UniProtKB: B5DF72 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006247431   ⟸   XM_006247369
- Peptide Label: isoform X2
- UniProtKB: B5DF72 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006247433   ⟸   XM_006247371
- Peptide Label: isoform X4
- UniProtKB: B5DF72 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006247432   ⟸   XM_006247370
- Peptide Label: isoform X4
- UniProtKB: B5DF72 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008766308   ⟸   XM_008768086
- Peptide Label: isoform X3
- UniProtKB: B5DF72 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017452889   ⟸   XM_017597400
- Peptide Label: isoform X1
- UniProtKB: B5DF72 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000028213   ⟸   ENSRNOT00000028213
Ensembl Acc Id: ENSRNOP00000070185   ⟸   ENSRNOT00000084311
RefSeq Acc Id: XP_038942335   ⟸   XM_039086407
- Peptide Label: isoform X5
- UniProtKB: E9PTJ2 (UniProtKB/TrEMBL),   A6HJF1 (UniProtKB/TrEMBL),   B5DF72 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038942338   ⟸   XM_039086410
- Peptide Label: isoform X6
- UniProtKB: A0A8I6AQD4 (UniProtKB/TrEMBL),   A6HJF2 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000096295   ⟸   ENSRNOT00000105588
RefSeq Acc Id: XP_063125513   ⟸   XM_063269443
- Peptide Label: isoform X1
- UniProtKB: B5DF72 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063125514   ⟸   XM_063269444
- Peptide Label: isoform X7
Protein Domains
ETS

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2JX95-F1-model_v2 AlphaFold A0A0G2JX95 1-487 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697769
Promoter ID:EPDNEW_R8293
Type:single initiation site
Name:Etv4_1
Description:ets variant 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01089,700,225 - 89,700,285EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1306524 AgrOrtholog
BioCyc Gene G2FUF-23147 BioCyc
Ensembl Genes ENSRNOG00000020792 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000028213 ENTREZGENE
  ENSRNOT00000028213.7 UniProtKB/TrEMBL
  ENSRNOT00000084311 ENTREZGENE
  ENSRNOT00000084311.2 UniProtKB/TrEMBL
  ENSRNOT00000105588.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.10.10 UniProtKB/TrEMBL
InterPro Ets_dom UniProtKB/TrEMBL
  ETS_fam UniProtKB/TrEMBL
  ETS_PEA3_N UniProtKB/TrEMBL
  WH-like_DNA-bd_sf UniProtKB/TrEMBL
  WH_DNA-bd_sf UniProtKB/TrEMBL
KEGG Report rno:360635 UniProtKB/TrEMBL
NCBI Gene 360635 ENTREZGENE
PANTHER ETS TRANSLOCATION VARIANT 4 UniProtKB/TrEMBL
  PTHR11849 UniProtKB/TrEMBL
Pfam Ets UniProtKB/TrEMBL
  ETS_PEA3_N UniProtKB/TrEMBL
PhenoGen Etv4 PhenoGen
PRINTS ETSDOMAIN UniProtKB/TrEMBL
PROSITE ETS_DOMAIN_1 UniProtKB/TrEMBL
  ETS_DOMAIN_2 UniProtKB/TrEMBL
  ETS_DOMAIN_3 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000020792 RatGTEx
SMART ETS UniProtKB/TrEMBL
Superfamily-SCOP SSF46785 UniProtKB/TrEMBL
UniProt A0A0G2JX95_RAT UniProtKB/TrEMBL
  A0A8I6AQD4 ENTREZGENE, UniProtKB/TrEMBL
  A6HJF1 ENTREZGENE, UniProtKB/TrEMBL
  A6HJF2 ENTREZGENE, UniProtKB/TrEMBL
  B5DF72 ENTREZGENE, UniProtKB/TrEMBL
  E9PTJ2 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-08-29 Etv4  ETS variant transcription factor 4  Etv4  ets variant 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-10-23 Etv4  ets variant 4  Etv4  ets variant gene 4 (E1A enhancer binding protein, E1AF)   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Etv4  ets variant gene 4 (E1A enhancer binding protein, E1AF)   Etv4_predicted  ets variant gene 4 (E1A enhancer binding protein, E1AF) (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Etv4_predicted  ets variant gene 4 (E1A enhancer binding protein, E1AF) (predicted)      Symbol and Name status set to approved 70820 APPROVED