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Gene: Adamtsl1 (ADAMTS-like 1) Rattus norvegicus

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Symbol:

Adamtsl1

Name:

ADAMTS-like 1

RGD ID:

1306439

Description:

Predicted to be involved in extracellular matrix organization. Predicted to be located in extracellular region. Predicted to be active in extracellular matrix. Orthologous to human ADAMTSL1 (ADAMTS like 1); INTERACTS WITH 6-propyl-2-thiouracil; bisphenol A; Cuprizon.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

AABR07049085.1; ADAMTS-like protein 1; LOC362539

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	ADAMTSL1 (ADAMTS like 1)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Adamtsl1 (ADAMTS-like 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Adamtsl1 (ADAMTS like 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	ADAMTSL1 (ADAMTS like 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	ADAMTSL1 (ADAMTS like 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Adamtsl1 (ADAMTS like 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	ADAMTSL1 (ADAMTS like 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	ADAMTSL1 (ADAMTS like 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Adamtsl1 (ADAMTS like 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	MRPL17 (mitochondrial ribosomal protein L17)	HGNC	OMA
Homo sapiens (human):	TMEM238 (transmembrane protein 238)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	ADAMTSL1 (ADAMTS like 1)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Adamtsl1 (ADAMTS-like 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	nolo	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	nolo	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	madd-4	Alliance	DIOPT (Hieranoid\|InParanoid\|PhylomeDB)
Caenorhabditis elegans (roundworm):	madd-4	Alliance	DIOPT (Hieranoid\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	adamtsl1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	105,010,471 - 105,965,792 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	5	105,010,464 - 105,964,394 (+)	Ensembl				GRCr8
mRatBN7.2	5	99,964,406 - 100,919,786 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	99,964,486 - 100,918,384 (+)	Ensembl				mRatBN7.2
Rnor_6.0	5	103,789,443 - 104,753,866 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	104,362,971 - 104,753,863 (+)	NCBI			rn6	Rnor6.0
Rnor_5.0	5	107,788,824 - 108,739,600 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	5	105,037,301 - 105,423,414 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	5	98,471,336 - 99,412,967 (+)	NCBI		Celera
RGSC_v3.1	5	104,922,036 - 105,276,337 (+)	NCBI
Cytogenetic Map	5	q31	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

orofacial cleft 1 (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dichloroethane (ISO)

1,2-dimethylhydrazine (ISO)

17beta-estradiol (ISO)

2,4-dibromophenyl 2,4,5-tribromophenyl ether (ISO)

2-palmitoylglycerol (ISO)

3-isobutyl-1-methyl-7H-xanthine (ISO)

4,4'-sulfonyldiphenol (ISO)

6-propyl-2-thiouracil (EXP)

aflatoxin B1 (ISO)

antirheumatic drug (ISO)

arsane (ISO)

arsenic atom (ISO)

arsenite(3-) (ISO)

benzo[a]pyrene (ISO)

benzo[e]pyrene (ISO)

bisphenol A (EXP,ISO)

bisphenol AF (ISO)

Bisphenol B (ISO)

bisphenol F (ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

carbon nanotube (ISO)

cobalt dichloride (ISO)

copper(II) sulfate (ISO)

Cuprizon (EXP)

dexamethasone (ISO)

doxorubicin (ISO)

entinostat (ISO)

ethylparaben (ISO)

fulvestrant (ISO)

GSK-J4 (ISO)

indometacin (ISO)

lead diacetate (ISO)

manganese atom (ISO)

manganese(0) (ISO)

manganese(II) chloride (ISO)

methapyrilene (ISO)

methimazole (EXP)

methoxychlor (EXP)

nickel atom (ISO)

nickel sulfate (ISO)

ozone (ISO)

phenobarbital (ISO)

progesterone (ISO)

resveratrol (ISO)

silicon dioxide (ISO)

sodium arsenate (ISO)

sodium arsenite (ISO)

sulfadimethoxine (EXP)

sunitinib (ISO)

titanium dioxide (ISO)

toluene (ISO)

triclosan (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

biological_process (ND)

extracellular matrix organization (IEA)

Cellular Component

extracellular matrix (IBA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
3.	GOA pipeline	RGD automated data pipeline
4.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
6.	Comprehensive gene review and curation	RGD comprehensive gene curation

Genomics

Comparative Map Data

Adamtsl1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	105,010,471 - 105,965,792 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	5	105,010,464 - 105,964,394 (+)	Ensembl				GRCr8
mRatBN7.2	5	99,964,406 - 100,919,786 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	99,964,486 - 100,918,384 (+)	Ensembl				mRatBN7.2
Rnor_6.0	5	103,789,443 - 104,753,866 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	104,362,971 - 104,753,863 (+)	NCBI			rn6	Rnor6.0
Rnor_5.0	5	107,788,824 - 108,739,600 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	5	105,037,301 - 105,423,414 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	5	98,471,336 - 99,412,967 (+)	NCBI		Celera
RGSC_v3.1	5	104,922,036 - 105,276,337 (+)	NCBI
Cytogenetic Map	5	q31	NCBI

ADAMTSL1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	9	17,906,633 - 18,910,950 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	9	17,906,563 - 18,910,950 (+)	Ensembl			hg38	GRCh38
GRCh37	9	18,474,151 - 18,910,948 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	9	18,464,104 - 18,900,948 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	9	18,464,166 - 18,671,479	NCBI
Celera	9	18,399,808 - 18,837,144 (+)	NCBI		Celera
Cytogenetic Map	9	p22.2-p22.1	NCBI
HuRef	9	18,436,243 - 18,872,606 (+)	NCBI		HuRef
CHM1_1	9	18,473,863 - 18,910,945 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	9	17,919,720 - 18,923,930 (+)	NCBI		T2T-CHM13v2.0

Adamtsl1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	4	85,432,242 - 86,346,627 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	4	85,432,409 - 86,346,622 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	4	85,513,852 - 86,428,390 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	4	85,514,172 - 86,428,385 (+)	Ensembl			mm10	GRCm38
MGSCv37	4	85,699,819 - 86,074,286 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	4	85,525,183 - 85,747,822 (+)	NCBI		MGSCv36	mm8
Celera	4	84,566,896 - 84,943,706 (+)	NCBI		Celera
Cytogenetic Map	4	C4	NCBI
cM Map	4	40.32	NCBI

Adamtsl1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955434	21,006,135 - 21,392,937 (+)	Ensembl
ChiLan1.0	NW_004955434	20,929,569 - 21,392,319 (+)	NCBI	ChiLan1.0	ChiLan1.0

ADAMTSL1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	11	105,631,890 - 106,653,180 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	9	105,637,834 - 106,659,125 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	9	17,714,454 - 18,724,606 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	9	18,781,317 - 19,218,181 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	9	18,807,435 - 19,218,181 (+)	Ensembl			panPan2	panpan1.1

ADAMTSL1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	11	37,880,723 - 38,754,287 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	11	38,372,186 - 38,751,972 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	11	37,028,724 - 37,413,289 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	11	39,299,153 - 39,687,369 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	11	39,299,253 - 39,686,726 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	11	38,001,100 - 38,381,093 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	11	37,793,745 - 38,175,721 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	11	38,432,365 - 38,812,571 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Adamtsl1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	152,840,371 - 153,201,113 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936652	510,057 - 870,622 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936652	540,815 - 870,607 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ADAMTSL1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	203,936,657 - 204,942,412 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	1	203,936,654 - 204,944,236 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	227,766,939 - 227,856,082 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

ADAMTSL1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	12	60,805,450 - 61,221,464 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	12	60,805,479 - 61,056,333 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666038	48,931,205 - 49,353,576 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Adamtsl1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624736	21,827,706 - 22,899,800 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624736	22,455,837 - 22,901,566 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Variants

Variants in Adamtsl1
6014 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	125
Count of miRNA genes:	100
Interacting mature miRNAs:	115
Transcripts:	ENSRNOT00000009127, ENSRNOT00000058520
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1357396	Bw44	Body weight QTL 44	4.19		body mass (VT:0001259)	body weight (CMO:0000012)	5	73779642	118779642	Rat
1331796	Thshl2	Thyroid stimulating hormone level QTL 2	2.3		blood thyroid-stimulating hormone amount (VT:0005119)	serum thyroid stimulating hormone level (CMO:0001248)	5	102105698	152749382	Rat
2303586	Gluco52	Glucose level QTL 52	2		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	5	100826632	145826632	Rat
1549845	Scl44	Serum cholesterol level QTL 44	6		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	5	44924861	153890773	Rat
70212	Niddm25	Non-insulin dependent diabetes mellitus QTL 25	3.54		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	5	38207390	136631402	Rat
1298070	Scl18	Serum cholesterol level QTL 18	3.7		blood LDL cholesterol amount (VT:0000181)	calculated plasma low density lipoprotein cholesterol level (CMO:0001245)	5	84630798	129630798	Rat
61452	Ciaa5	CIA Autoantibody QTL 5	3.5		blood autoantibody amount (VT:0003725)	calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)	5	99905133	172190305	Rat
1331801	Rf33	Renal function QTL 33	4.149		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal vascular resistance (CMO:0001900)	5	48523123	134369373	Rat
2302381	Bw84	Body weight QTL 84	4.47		body mass (VT:0001259)	body mass index (BMI) (CMO:0000105)	5	73779642	118779642	Rat
1357402	Bw46	Body weight QTL 46	4.47		body mass (VT:0001259)	body mass index (BMI) (CMO:0000105)	5	73779642	118779642	Rat
7411582	Foco3	Food consumption QTL 3	7.5	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	5	92583776	137583776	Rat
61393	Bp7	Blood pressure QTL 7	4.5	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	65089051	166764498	Rat
1598859	Cm66	Cardiac mass QTL 66	2		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	5	84630798	129630798	Rat
1578766	Tcas11	Tongue tumor susceptibility QTL 11	4.12		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	5	51657967	166600247	Rat
1582212	Livw2	Liver weight QTL 2	3.5	0.0004	liver mass (VT:0003402)	liver weight to body weight ratio (CMO:0000633)	5	104018576	124314782	Rat
7411564	Bw135	Body weight QTL 135		0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	5	92583776	137583776	Rat
8657050	Bw146	Body weight QTL 146	19.84	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	5	98972960	143972960	Rat
1576312	Emca8	Estrogen-induced mammary cancer QTL 8	4.1		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	55124766	172190305	Rat
7411601	Foco12	Food consumption QTL 12	19.7	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	5	92583776	137583776	Rat
2303618	Vencon1	Ventilatory control QTL 1	3.8		respiration trait (VT:0001943)	oxygen consumption (CMO:0002169)	5	100826632	145826632	Rat
7394708	Emca11	Estrogen-induced mammary cancer QTL 11			mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	73176602	118176602	Rat
1598846	Bp293	Blood pressure QTL 293	3.9		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	84630798	129630798	Rat
7394710	Emca12	Estrogen-induced mammary cancer QTL 12			mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	94034903	139034903	Rat
1578673	Bmd13	Bone mineral density QTL 13	4.9		femur mineral mass (VT:0010011)	trabecular volumetric bone mineral density (CMO:0001729)	5	69474415	114474415	Rat
1358909	Kidm25	Kidney mass QTL 25	1.87		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	5	95062526	133270832	Rat
70189	Mcs5	Mammary carcinoma susceptibility QTL 5	10.51		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	60601597	137492949	Rat
61359	Eaex	Experimental allergic encephalomyelitis QTL x	3		nervous system integrity trait (VT:0010566)	post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)	5	60511627	105511627	Rat
2290448	Scl54	Serum cholesterol level QTL 54	2.93		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	5	36460764	136631402	Rat
61426	Scl2	Serum cholesterol level QTL 2	7.3	0.001	blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	5	64589016	109589016	Rat
1354598	Srn6	Serum renin concentration QTL 6	3.8		blood renin amount (VT:0003349)	plasma renin activity level (CMO:0000116)	5	74335621	156302135	Rat
1600362	Mcs19	Mammary carcinoma susceptibility QTL 19	2.5		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	82032155	127032155	Rat
1298086	Bp156	Blood pressure QTL 156			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	89369373	134369373	Rat
2290005	Mcs24	Mammary carcinoma susceptibility QTL 24			mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	69835120	114835120	Rat
2306971	Anxrr21	Anxiety related response QTL 21	9.47		fear/anxiety-related behavior trait (VT:1000241)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	5	70969494	136328156	Rat
1358895	Bp254	Blood pressure QTL 254	3.6	0.0003	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	5	97492524	133270832	Rat
2312671	Scl64	Serum cholesterol level QTL 64		0.001	blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	5	73779642	118779642	Rat
6903316	Bw113	Body weight QTL 113	2	0.0103	body mass (VT:0001259)	body weight (CMO:0000012)	5	92881678	137881678	Rat
1358889	Bp261	Blood pressure QTL 261	2.86		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	5	95062526	133270832	Rat
1358187	Emca1	Estrogen-induced mammary cancer QTL 1	4.4		mammary gland integrity trait (VT:0010552)	post-insult time to mammary tumor formation (CMO:0000345)	5	104262817	153890625	Rat

Markers in Region

D5Got30

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	5	100,749,175 - 100,749,308 (+)	MAPPER	mRatBN7.2
Rnor_6.0	5	104,577,904 - 104,578,036	NCBI	Rnor6.0
Rnor_5.0	5	108,570,666 - 108,570,798	UniSTS	Rnor5.0
RGSC_v3.4	5	105,254,629 - 105,254,762	RGD	RGSC3.4
RGSC_v3.4	5	105,254,630 - 105,254,762	UniSTS	RGSC3.4
Celera	5	99,248,412 - 99,248,544	UniSTS
RGSC_v3.1	5	105,259,856 - 105,259,988	RGD
RH 3.4 Map	5	735.4	UniSTS
RH 3.4 Map	5	735.4	RGD
RH 2.0 Map	5	657.4	RGD
Cytogenetic Map	5	q32	UniSTS

AU048191

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	5	100,713,273 - 100,713,383 (+)	MAPPER	mRatBN7.2
Rnor_6.0	5	104,541,999 - 104,542,108	NCBI	Rnor6.0
Rnor_5.0	5	108,534,761 - 108,534,870	UniSTS	Rnor5.0
RGSC_v3.4	5	105,218,679 - 105,218,788	UniSTS	RGSC3.4
Celera	5	99,212,468 - 99,212,577	UniSTS
Cytogenetic Map	5	q32	UniSTS

At-8BJ-008

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_6.0	5	104,598,267 - 104,599,484	NCBI	Rnor6.0
Rnor_5.0	5	108,591,029 - 108,592,187	UniSTS	Rnor5.0
Celera	5	99,268,753 - 99,270,096	UniSTS
Cytogenetic Map	5	q32	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	hemolymphoid system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	sensory system	visual system
3	1	18	40	35	101	63	11	39	35	32	13	13

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001431177	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001431178	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017593921	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017602897	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017602898	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017602899	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017602900	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017602901	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017602902	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039111079	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039111080	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039111081	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039111082	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039111083	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039111084	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039111086	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAXUCZ010000005	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000058520 ⟹ ENSRNOP00000055317

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	5	105,010,464 - 105,964,394 (+)	Ensembl
mRatBN7.2 Ensembl	5	99,964,486 - 100,918,384 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000093462 ⟹ ENSRNOP00000076109

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	5	105,578,591 - 105,964,394 (+)	Ensembl
mRatBN7.2 Ensembl	5	100,532,557 - 100,918,384 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000093557 ⟹ ENSRNOP00000076311

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	5	105,578,724 - 105,964,394 (+)	Ensembl
mRatBN7.2 Ensembl	5	100,532,557 - 100,918,384 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000124723 ⟹ ENSRNOP00000098750

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	5	105,697,012 - 105,964,394 (+)	Ensembl

RefSeq Acc Id:

XM_039111079 ⟹ XP_038967007

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	105,010,517 - 105,965,792 (+)	NCBI
mRatBN7.2	5	99,964,446 - 100,919,786 (+)	NCBI

RefSeq Acc Id:

XM_039111080 ⟹ XP_038967008

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	105,010,516 - 105,965,792 (+)	NCBI
mRatBN7.2	5	99,964,444 - 100,919,786 (+)	NCBI

RefSeq Acc Id:

XM_039111081 ⟹ XP_038967009

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	105,578,613 - 105,965,792 (+)	NCBI
mRatBN7.2	5	100,532,468 - 100,919,786 (+)	NCBI

RefSeq Acc Id:

XM_039111082 ⟹ XP_038967010

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	105,578,613 - 105,965,792 (+)	NCBI
mRatBN7.2	5	100,532,477 - 100,919,786 (+)	NCBI

RefSeq Acc Id:

XM_039111083 ⟹ XP_038967011

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	105,578,613 - 105,965,792 (+)	NCBI
mRatBN7.2	5	100,532,474 - 100,919,786 (+)	NCBI

RefSeq Acc Id:

XM_039111084 ⟹ XP_038967012

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	105,010,471 - 105,965,792 (+)	NCBI
mRatBN7.2	5	99,964,406 - 100,919,786 (+)	NCBI

RefSeq Acc Id:

XM_039111086 ⟹ XP_038967014

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	105,777,182 - 105,965,792 (+)	NCBI
mRatBN7.2	5	100,731,143 - 100,919,786 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001418106	(Get FASTA)	NCBI Sequence Viewer
	NP_001418107	(Get FASTA)	NCBI Sequence Viewer
	XP_038967007	(Get FASTA)	NCBI Sequence Viewer
	XP_038967008	(Get FASTA)	NCBI Sequence Viewer
	XP_038967009	(Get FASTA)	NCBI Sequence Viewer
	XP_038967010	(Get FASTA)	NCBI Sequence Viewer
	XP_038967011	(Get FASTA)	NCBI Sequence Viewer
	XP_038967012	(Get FASTA)	NCBI Sequence Viewer
	XP_038967014	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000055317
	ENSRNOP00000055317.5
	ENSRNOP00000076109
	ENSRNOP00000076109.2
	ENSRNOP00000076311
	ENSRNOP00000076311.2
	ENSRNOP00000098750.1

RefSeq Acc Id:	XP_038967012 ⟸ XM_039111084
- Peptide Label:	isoform X6

RefSeq Acc Id:	XP_038967008 ⟸ XM_039111080
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_038967007 ⟸ XM_039111079
- Peptide Label:	isoform X1
- UniProtKB:	F1LWA1 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038967009 ⟸ XM_039111081
- Peptide Label:	isoform X3

RefSeq Acc Id:	XP_038967011 ⟸ XM_039111083
- Peptide Label:	isoform X5
- UniProtKB:	A0A1W2Q6M9 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038967010 ⟸ XM_039111082
- Peptide Label:	isoform X4

RefSeq Acc Id:	XP_038967014 ⟸ XM_039111086
- Peptide Label:	isoform X7

Ensembl Acc Id:

ENSRNOP00000076311 ⟸ ENSRNOT00000093557

Ensembl Acc Id:

ENSRNOP00000055317 ⟸ ENSRNOT00000058520

Ensembl Acc Id:

ENSRNOP00000076109 ⟸ ENSRNOT00000093462

Ensembl Acc Id:

ENSRNOP00000098750 ⟸ ENSRNOT00000124723

Protein Domains

Ig-like PLAC

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-A0A1W2Q6M9-F1-model_v2	AlphaFold	A0A1W2Q6M9	1-1383	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1306439	AgrOrtholog
BioCyc Gene	G2FUF-40852	BioCyc
Ensembl Genes	ENSRNOG00000006956	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000058520	ENTREZGENE
	ENSRNOT00000058520.7	UniProtKB/TrEMBL
	ENSRNOT00000093462	ENTREZGENE
	ENSRNOT00000093462.3	UniProtKB/TrEMBL
	ENSRNOT00000093557	ENTREZGENE
	ENSRNOT00000093557.3	UniProtKB/TrEMBL
	ENSRNOT00000124723.1	UniProtKB/TrEMBL
Gene3D-CATH	2.20.100.10	UniProtKB/TrEMBL
	2.60.120.830	UniProtKB/TrEMBL
	2.60.40.10	UniProtKB/TrEMBL
InterPro	ADAMTS/ADAMTS-like	UniProtKB/TrEMBL
	ADAMTS_ADAMTS-like	UniProtKB/TrEMBL
	ADAMTS_CR_3	UniProtKB/TrEMBL
	ADAMTS_spacer1	UniProtKB/TrEMBL
	ADAMTSL1_dom	UniProtKB/TrEMBL
	Ig-like_dom	UniProtKB/TrEMBL
	Ig-like_dom_sf	UniProtKB/TrEMBL
	Ig-like_fold	UniProtKB/TrEMBL
	Ig_I-set	UniProtKB/TrEMBL
	Ig_sub	UniProtKB/TrEMBL
	Ig_sub2	UniProtKB/TrEMBL
	PLAC	UniProtKB/TrEMBL
	TSP1_rpt	UniProtKB/TrEMBL
	TSP1_rpt_sf	UniProtKB/TrEMBL
NCBI Gene	362539	ENTREZGENE
PANTHER	ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE	UniProtKB/TrEMBL
	ADAMTS-LIKE PROTEIN 1	UniProtKB/TrEMBL
Pfam	ADAM_CR_3	UniProtKB/TrEMBL
	ADAM_spacer1	UniProtKB/TrEMBL
	ADAMTSL1	UniProtKB/TrEMBL
	I-set	UniProtKB/TrEMBL
	Ig_3	UniProtKB/TrEMBL
	PLAC	UniProtKB/TrEMBL
	TSP1_ADAMTS	UniProtKB/TrEMBL
	TSP_1	UniProtKB/TrEMBL
PhenoGen	Adamtsl1	PhenoGen
PRINTS	ADAMTSFAMILY	UniProtKB/TrEMBL
PROSITE	IG_LIKE	UniProtKB/TrEMBL
	PLAC	UniProtKB/TrEMBL
	TSP1	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000006956	RatGTEx
SMART	IGc2	UniProtKB/TrEMBL
	SM00409	UniProtKB/TrEMBL
	TSP1	UniProtKB/TrEMBL
Superfamily-SCOP	SSF48726	UniProtKB/TrEMBL
	SSF82895	UniProtKB/TrEMBL
UniProt	A0A1W2Q621	ENTREZGENE, UniProtKB/TrEMBL
	A0A1W2Q6M9	ENTREZGENE, UniProtKB/TrEMBL
	A0ABK0L7P6_RAT	UniProtKB/TrEMBL
	F1LWA1	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2022-06-02	Adamtsl1	ADAMTS-like 1	AABR07049085.1		Data merged from RGD:15003322	737654	PROVISIONAL
2021-09-02	AABR07049085.1		Adamtsl1	ADAMTS-like 1	Symbol and/or name change	19259462	PROVISIONAL
2021-08-09	Adamtsl1	ADAMTS-like 1	AABR07049085.1		Symbol and/or name change	19259462	PROVISIONAL
2019-11-08	AABR07049085.1				Symbol and Name status set to provisional	45752	PROVISIONAL
2008-04-30	Adamtsl1	ADAMTS-like 1	Adamtsl1_predicted	ADAMTS-like 1 (predicted)	'predicted' is removed	2292626	APPROVED
2008-01-09	Adamtsl1_predicted	ADAMTS-like 1 (predicted)	LOC683529	similar to ADAMTS-like 1 isoform 1	Data merged from RGD:1585665	1643240	APPROVED
2006-11-19	LOC683529	similar to ADAMTS-like 1 isoform 1			Symbol and Name status set to provisional	70820	PROVISIONAL
2005-01-12	Adamtsl1_predicted	ADAMTS-like 1 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar