Ca9 (carbonic anhydrase 9) - Rat Genome Database

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Gene: Ca9 (carbonic anhydrase 9) Rattus norvegicus
Analyze
Symbol: Ca9 (Ensembl: Car9)
Name: carbonic anhydrase 9
RGD ID: 1306426
Description: Predicted to enable carbonate dehydratase activity; molecular function activator activity; and zinc ion binding activity. Involved in response to hypoxia; response to testosterone; and response to xenobiotic stimulus. Located in basolateral plasma membrane. Human ortholog(s) of this gene implicated in hepatitis B; lung non-small cell carcinoma; and renal cell carcinoma. Orthologous to human CA9 (carbonic anhydrase 9); PARTICIPATES IN hypoxia inducible factor pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; acetamide; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Car9; carbonic anhydrase IX; LOC313495
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8562,559,024 - 62,565,626 (+)NCBIGRCr8
GRCr8 Ensembl562,558,823 - 62,565,626 (+)EnsemblGRCr8 Ensembl
mRatBN7.2557,763,234 - 57,769,838 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl557,763,206 - 57,769,838 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx559,743,112 - 59,749,748 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0561,561,925 - 61,568,564 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0561,533,190 - 61,539,753 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0559,008,277 - 59,015,535 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl559,008,933 - 59,015,528 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0563,533,527 - 63,540,129 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4559,986,413 - 59,993,015 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera556,343,808 - 56,350,416 (+)NCBICelera
RGSC_v3.1559,986,589 - 59,992,484 (+)NCBI
Cytogenetic Map5q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,10-phenanthroline  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-hydroxypropanoic acid  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-methylumbelliferyl beta-D-galactoside  (ISO)
4-nitrophenol  (ISO)
acetamide  (EXP)
acetazolamide  (ISO)
acrylamide  (ISO)
amphotericin B  (ISO)
ampicillin  (ISO)
antirheumatic drug  (ISO)
Archazolid B  (ISO)
aristolochic acid A  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
betulin  (ISO)
betulinic acid  (ISO)
bezafibrate  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bleomycin A5  (ISO)
bortezomib  (ISO)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
butyric acid  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
captan  (ISO)
carbonates  (ISO)
CAY10591  (ISO)
ceric oxide  (ISO)
CGP 52608  (ISO)
chloric acid  (ISO)
chlorpyrifos  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
cobalt atom  (ISO)
cobalt dichloride  (EXP,ISO)
cobalt(2+) sulfate  (ISO)
copper(II) chloride  (ISO)
crocidolite asbestos  (ISO)
curcumin  (EXP)
cyclosporin A  (ISO)
deguelin  (ISO)
desferrioxamine B  (ISO)
diarsenic trioxide  (ISO)
diisononyl phthalate  (ISO)
dimethylarsinous acid  (ISO)
dioxygen  (EXP,ISO)
doxorubicin  (ISO)
ethanol  (ISO)
fenofibrate  (ISO)
folpet  (ISO)
gemfibrozil  (ISO)
Genipin  (ISO)
heptanal  (ISO)
hexanal  (ISO)
hydroquinone  (ISO)
iron(III) citrate  (ISO)
L-ascorbic acid  (ISO)
lead diacetate  (ISO)
lead nitrate  (ISO)
lead(0)  (ISO)
LY294002  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
molibresib  (ISO)
molybdate  (ISO)
N-Nitrosopyrrolidine  (ISO)
nickel dichloride  (ISO)
nickel sulfate  (ISO)
nitric acid  (ISO)
Nonidet P-40  (ISO)
O-methyleugenol  (ISO)
octanal  (ISO)
okadaic acid  (ISO)
oryzalin  (ISO)
oxaliplatin  (ISO)
paracetamol  (EXP,ISO)
pentanal  (ISO)
perchlorate  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
pirinixic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
propanal  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
serpentine asbestos  (ISO)
silibinin  (ISO)
silicon dioxide  (ISO)
SLC-0111  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
sotorasib  (ISO)
sulfamic acid  (ISO)
sulfates  (ISO)
sulindac  (ISO)
temozolomide  (ISO)
thiram  (ISO)
trametinib  (ISO)
tributylstannane  (EXP)
Triptolide  (ISO)
tungstate  (ISO)
Tungsten carbide  (ISO)
urethane  (ISO)
valproic acid  (EXP)
vorinostat  (ISO)
zinc dichloride  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Suppression of the hypoxia-inducible factor-1 response in cervical carcinoma xenografts by proteasome inhibitors. Birle DC and Hedley DW, Cancer Res. 2007 Feb 15;67(4):1735-43.
2. Hypomethylation of the MN/CA9 promoter and upregulated MN/CA9 expression in human renal cell carcinoma. Cho M, etal., Br J Cancer. 2001 Aug 17;85(4):563-7.
3. Immunotargeting of human cervical carcinoma xenograft expressing CA IX tumor-associated antigen by 125I-labeled M75 monoclonal antibody. Chrastina A, etal., Neoplasma. 2003;50(1):13-21.
4. New Gene Variants Associated with the Risk of Chronic HBV Infection. Fan M, etal., Virol Sin. 2020 Aug;35(4):378-387. doi: 10.1007/s12250-020-00200-x. Epub 2020 Apr 15.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. Induction of carbonic anhydrase IX by hypoxia and chemical disruption of oxygen sensing in rat fibroblasts and cardiomyocytes. Holotnakova T, etal., Pflugers Arch. 2008 May;456(2):323-37. Epub 2007 Dec 11.
8. p16 is consistently expressed in endometrial tubal metaplasia. Horree N, etal., Cell Oncol. 2007;29(1):37-45.
9. Hypoxia and angiogenesis in endometrioid endometrial carcinogenesis. Horree N, etal., Cell Oncol. 2007;29(3):219-27.
10. GLUT1 and CAIX as intrinsic markers of hypoxia in bladder cancer: relationship with vascularity and proliferation as predictors of outcome of ARCON. Hoskin PJ, etal., Br J Cancer. 2003 Oct 6;89(7):1290-7.
11. Carbonic anhydrase IX, a marker of hypoxia: correlation with clinical outcome in transitional cell carcinoma of the bladder. Hussain SA, etal., Oncol Rep. 2004 May;11(5):1005-10.
12. Response of CAIX and CAXII to in vitro re-oxygenation and clinical significance of the combined expression in NSCLC patients. Ilie M, etal., Lung Cancer. 2013 Oct;82(1):16-23. doi: 10.1016/j.lungcan.2013.07.005. Epub 2013 Jul 30.
13. pH regulators to target the tumor immune microenvironment in human hepatocellular carcinoma. Kuchuk O, etal., Oncoimmunology. 2018 Mar 26;7(7):e1445452. doi: 10.1080/2162402X.2018.1445452. eCollection 2018.
14. Tumor carbonic anhydrase 9 expression is associated with the presence of lymph node metastases in uterine cervical cancer. Lee S, etal., Cancer Sci. 2007 Mar;98(3):329-33. Epub 2007 Jan 12.
15. Hypoxia and its downstream targets in DMBA induced mammary carcinoma: protective role of Semecarpus anacardium nut extract. Mathivadhani P, etal., Chem Biol Interact. 2007 Apr 5;167(1):31-40. Epub 2007 Jan 10.
16. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
17. Carbonic anhydrase IX is highly expressed in hereditary nonpolyposis colorectal cancer. Niemelä AM, etal., Cancer Epidemiol Biomarkers Prev. 2007 Sep;16(9):1760-6. doi: 10.1158/1055-9965.EPI-07-0080.
18. Carbonic anhydrase IX, MN/CA IX: analysis of stomach complementary DNA sequence and expression in human and rat alimentary tracts. Pastorekova S, etal., Gastroenterology. 1997 Feb;112(2):398-408.
19. Low CAIX expression and absence of VHL gene mutation are associated with tumor aggressiveness and poor survival of clear cell renal cell carcinoma. Patard JJ, etal., Int J Cancer. 2008 May 7;123(2):395-400.
20. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
21. GOA pipeline RGD automated data pipeline
22. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
23. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
24. Comprehensive gene review and curation RGD comprehensive gene curation
25. Testosterone-stimulated growth of the rat prostate may be driven by tissue hypoxia and hypoxia-inducible factor-1alpha. Rudolfsson SH and Bergh A, J Endocrinol. 2008 Jan;196(1):11-9.
26. Induction of antigen specific cellular immunity by vaccination with peptides from MN/CA IX in renal cell carcinoma. Shimizu K, etal., Oncol Rep. 2003 Sep-Oct;10(5):1307-11.
27. Changes in the expression and/or activation of regulatory proteins in rat hearts adapted to chronic hypoxia. Strniskova M, etal., Gen Physiol Biophys. 2006 Mar;25(1):25-41.
28. HIF-1alpha and CA IX staining in invasive breast carcinomas: prognosis and treatment outcome. Trastour C, etal., Int J Cancer. 2007 Apr 1;120(7):1451-8.
29. Gene Expression Profiles Associated with the Presence of a Fibrotic Focus and the Growth Pattern in Lymph Node-Negative Breast Cancer. Van den Eynden GG, etal., Clin Cancer Res. 2008 May 15;14(10):2944-2952.
30. Soluble form of carbonic anhydrase IX (CA IX) in the serum and urine of renal carcinoma patients. Zavada J, etal., Br J Cancer. 2003 Sep 15;89(6):1067-71.
Additional References at PubMed
PMID:16217040   PMID:16831598   PMID:22087255   PMID:22538240   PMID:28940640   PMID:29631360   PMID:34231059   PMID:34251286  


Genomics

Comparative Map Data
Ca9
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8562,559,024 - 62,565,626 (+)NCBIGRCr8
GRCr8 Ensembl562,558,823 - 62,565,626 (+)EnsemblGRCr8 Ensembl
mRatBN7.2557,763,234 - 57,769,838 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl557,763,206 - 57,769,838 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx559,743,112 - 59,749,748 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0561,561,925 - 61,568,564 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0561,533,190 - 61,539,753 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0559,008,277 - 59,015,535 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl559,008,933 - 59,015,528 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0563,533,527 - 63,540,129 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4559,986,413 - 59,993,015 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera556,343,808 - 56,350,416 (+)NCBICelera
RGSC_v3.1559,986,589 - 59,992,484 (+)NCBI
Cytogenetic Map5q22NCBI
CA9
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38935,673,928 - 35,681,159 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl935,673,928 - 35,681,159 (+)EnsemblGRCh38hg38GRCh38
GRCh37935,673,925 - 35,681,156 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36935,663,915 - 35,671,152 (+)NCBINCBI36Build 36hg18NCBI36
Build 34935,663,914 - 35,671,152NCBI
Celera935,607,463 - 35,614,702 (+)NCBICelera
Cytogenetic Map9p13.3NCBI
HuRef935,629,523 - 35,636,764 (+)NCBIHuRef
CHM1_1935,673,743 - 35,680,984 (+)NCBICHM1_1
T2T-CHM13v2.0935,694,579 - 35,701,811 (+)NCBIT2T-CHM13v2.0
Car9
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39443,507,026 - 43,513,729 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl443,506,966 - 43,513,729 (+)EnsemblGRCm39 Ensembl
GRCm38443,507,026 - 43,513,729 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl443,506,966 - 43,513,729 (+)EnsemblGRCm38mm10GRCm38
MGSCv37443,519,898 - 43,526,597 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36443,528,107 - 43,534,829 (+)NCBIMGSCv36mm8
Celera443,540,895 - 43,547,584 (+)NCBICelera
Cytogenetic Map4A5NCBI
cM Map423.05NCBI
Ca9
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955472619,245 - 625,051 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955472619,084 - 625,570 (-)NCBIChiLan1.0ChiLan1.0
CA9
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21188,906,190 - 88,913,457 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1988,912,119 - 88,919,393 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0935,525,877 - 35,533,159 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1936,328,205 - 36,335,474 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl936,328,303 - 36,335,340 (+)Ensemblpanpan1.1panPan2
CA9
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11152,205,619 - 52,211,281 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1152,205,668 - 52,211,267 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1150,773,252 - 50,778,851 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01153,270,515 - 53,276,220 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1153,270,614 - 53,276,220 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11151,815,201 - 51,820,803 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01151,798,686 - 51,804,281 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01152,500,820 - 52,506,421 (+)NCBIUU_Cfam_GSD_1.0
Ca9
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947167,124,669 - 167,131,057 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365243,672,541 - 3,678,433 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365243,672,393 - 3,678,630 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CA9
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1236,394,306 - 236,400,822 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11236,393,727 - 236,400,994 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21264,118,816 - 264,126,024 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CA9
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11244,921,530 - 44,929,504 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1244,921,665 - 44,928,831 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603842,026,370 - 42,034,593 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ca9
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248685,109,846 - 5,116,949 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248685,110,602 - 5,131,167 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ca9
43 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:286
Count of miRNA genes:157
Interacting mature miRNAs:175
Transcripts:ENSRNOT00000023060
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578776Stresp18Stress response QTL 182.9thymus mass (VT:0004954)thymus wet weight (CMO:0000855)53275164977751649Rat
1298067Scl15Serum cholesterol level QTL 154.80.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)53801167083011670Rat
1300115Hrtrt7Heart rate QTL 72.76heart pumping trait (VT:2000009)heart rate (CMO:0000002)55266537294894052Rat
6907115Mcs29Mammary carcinoma susceptibility QTL 29mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)53800433183004331Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)544924861153890773Rat
1358353Srcrtb2Stress Responsive Cort Basal QTL 23.480.003blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)52367149379046465Rat
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)538207390136631402Rat
634305Mamtr1Mammary tumor resistance QTL 10.0001mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)51757663362576633Rat
1331801Rf33Renal function QTL 334.149kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)548523123134369373Rat
1598807Glom12Glomerulus QTL 122.7kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)53801167083011670Rat
1302786Kidm8Kidney mass QTL 828.15kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)53801167083011670Rat
1331782Rf36Renal function QTL 363.296kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)539019942102105896Rat
6903292Stl28Serum triglyceride level QTL 282.60.0073blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)53331167378311673Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)551657967166600247Rat
1578767Stresp17Stress response QTL 174.30.01blood aldosterone amount (VT:0005346)plasma aldosterone level (CMO:0000551)53275164977751649Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555124766172190305Rat
1641912Alcrsp18Alcohol response QTL 18response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)53998594884985948Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)5692228281330203Rat
6903306Scl35Serum cholesterol QTL 352.60.0073blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)53331167378311673Rat
1576317Eutr2Estrogen induced uterine response QTL 20.01uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)53952692484526924Rat
1331773Scl26Serum cholesterol level QTL 263.065blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)54852312391770353Rat
70189Mcs5Mammary carcinoma susceptibility QTL 510.51mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)560601597137492949Rat
1331771Rf35Renal function QTL 354.36965kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)51001906491770353Rat
61359EaexExperimental allergic encephalomyelitis QTL x3nervous system integrity trait (VT:0010566)post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)560511627105511627Rat
8662454Vetf3Vascular elastic tissue fragility QTL 327.4artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)5706553574335773Rat
2290448Scl54Serum cholesterol level QTL 542.93blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)536460764136631402Rat
1331756Rf34Renal function QTL 344.16275kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)51001906487027358Rat
8552954Pigfal14Plasma insulin-like growth factor 1 level QTL 149blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)52602321171023211Rat
2316959Gluco59Glucose level QTL 594.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)556546393101546393Rat
1600358Mamtr5Mammary tumor resistance QTL 5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)52367149368671493Rat

Markers in Region
BE110956  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2557,767,613 - 57,767,802 (+)MAPPERmRatBN7.2
Rnor_6.0559,013,311 - 59,013,499NCBIRnor6.0
Rnor_5.0563,537,905 - 63,538,093UniSTSRnor5.0
RGSC_v3.4559,990,791 - 59,990,979UniSTSRGSC3.4
Celera556,348,192 - 56,348,380UniSTS
RH 3.4 Map5378.7UniSTS
Cytogenetic Map5q22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
9 11 49 113 91 90 59 25 59 6 216 97 11 93 43 60 31 8 8

Sequence


Ensembl Acc Id: ENSRNOT00000023060   ⟹   ENSRNOP00000023060
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl562,558,823 - 62,565,626 (+)Ensembl
mRatBN7.2 Ensembl557,763,206 - 57,769,838 (+)Ensembl
Rnor_6.0 Ensembl559,008,933 - 59,015,528 (+)Ensembl
RefSeq Acc Id: NM_001107956   ⟹   NP_001101426
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8562,559,024 - 62,565,626 (+)NCBI
mRatBN7.2557,763,234 - 57,769,838 (+)NCBI
Rnor_6.0559,008,933 - 59,015,535 (+)NCBI
Rnor_5.0563,533,527 - 63,540,129 (+)NCBI
RGSC_v3.4559,986,413 - 59,993,015 (+)RGD
Celera556,343,808 - 56,350,416 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001101426 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein ABM64773 (Get FASTA)   NCBI Sequence Viewer  
  EDL98746 (Get FASTA)   NCBI Sequence Viewer  
  EDL98747 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000023060
  ENSRNOP00000023060.5
RefSeq Acc Id: NP_001101426   ⟸   NM_001107956
- Peptide Label: precursor
- UniProtKB: F7FL00 (UniProtKB/TrEMBL),   A6IJ26 (UniProtKB/TrEMBL),   A2IBE1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000023060   ⟸   ENSRNOT00000023060
Protein Domains
Alpha-carbonic anhydrase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F7FL00-F1-model_v2 AlphaFold F7FL00 1-437 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693676
Promoter ID:EPDNEW_R4201
Type:multiple initiation site
Name:Car9_1
Description:carbonic anhydrase 9
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0559,008,950 - 59,009,010EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1306426 AgrOrtholog
BioCyc Gene G2FUF-41507 BioCyc
Ensembl Genes ENSRNOG00000017073 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000023060 ENTREZGENE
  ENSRNOT00000023060.6 UniProtKB/TrEMBL
Gene3D-CATH 3.10.200.10 UniProtKB/TrEMBL
InterPro Carbonic_anhydrase_a UniProtKB/TrEMBL
  Carbonic_anhydrase_a-class UniProtKB/TrEMBL
  Carbonic_anhydrase_a-class_CS UniProtKB/TrEMBL
  Carbonic_anhydrase_a_sf UniProtKB/TrEMBL
KEGG Report rno:313495 UniProtKB/TrEMBL
NCBI Gene 313495 ENTREZGENE
PANTHER PTHR18952 UniProtKB/TrEMBL
  PTHR18952:SF18 UniProtKB/TrEMBL
Pfam Carb_anhydrase UniProtKB/TrEMBL
PhenoGen Ca9 PhenoGen
PROSITE ALPHA_CA_1 UniProtKB/TrEMBL
  ALPHA_CA_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000017073 RatGTEx
SMART Carb_anhydrase UniProtKB/TrEMBL
Superfamily-SCOP Euk_COanhd UniProtKB/TrEMBL
UniProt A2IBE1 ENTREZGENE
  A6IJ26 ENTREZGENE, UniProtKB/TrEMBL
  F7FL00 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary A2IBE1 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2025-04-28 Ca9  carbonic anhydrase 9  Car9  carbonic anhydrase 9  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2022-04-18 Car9  carbonic anhydrase 9  Ca9  carbonic anhydrase 9  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2019-04-16 Ca9  carbonic anhydrase 9  Car9  carbonic anhydrase 9  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Car9  carbonic anhydrase 9   Car9_predicted  carbonic anhydrase 9 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Car9_predicted  carbonic anhydrase 9 (predicted)      Symbol and Name status set to approved 70820 APPROVED