Eml1 (EMAP like 1) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Eml1 (EMAP like 1) Rattus norvegicus
Analyze
Symbol: Eml1
Name: EMAP like 1
RGD ID: 1306374
Description: Predicted to enable microtubule binding activity. Predicted to be involved in brain development; mitotic spindle organization; and neuroblast proliferation. Predicted to act upstream of or within hematopoietic progenitor cell differentiation. Predicted to be located in cytosol and microtubule cytoskeleton. Predicted to colocalize with mitotic spindle. Used to study epilepsy and subcortical band heterotopia. Human ortholog(s) of this gene implicated in skin melanoma and subcortical band heterotopia. Orthologous to human EML1 (EMAP like 1); INTERACTS WITH acetamide; atrazine; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: echinoderm microtubule associated protein like 1; echinoderm microtubule-associated protein-like 1; EMAP-1; LOC362783; MGC114510
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Eml1tish
Genetic Models: SD-Eml1tish/Scrb
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86133,048,271 - 133,221,642 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl6133,048,427 - 133,221,642 (+)EnsemblGRCr8
mRatBN7.26127,283,968 - 127,457,246 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6127,284,029 - 127,457,246 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx6127,408,913 - 127,581,347 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06127,703,970 - 127,876,401 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06127,061,846 - 127,234,628 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.06132,367,342 - 132,450,488 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6132,383,337 - 132,450,393 (+)Ensemblrn6Rnor6.0
Rnor_5.06141,536,753 - 141,619,726 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.46132,825,590 - 132,880,169 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera6124,926,667 - 125,013,010 (+)NCBICelera
RGSC_v3.16132,831,776 - 132,886,352 (+)NCBI
Cytogenetic Map6q32NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4,6-tribromophenol  (ISO)
2-hydroxypropanoic acid  (ISO)
2-palmitoylglycerol  (ISO)
4,4'-sulfonyldiphenol  (ISO)
acetamide  (EXP)
acrolein  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
bisphenol A  (EXP,ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cantharidin  (ISO)
carbon nanotube  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
chrysene  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
decabromodiphenyl ether  (ISO)
diarsenic trioxide  (ISO)
diuron  (EXP)
doxorubicin  (ISO)
ethanol  (ISO)
folic acid  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
ivermectin  (ISO)
L-methionine  (ISO)
Mesaconitine  (EXP)
methamphetamine  (EXP)
methylmercury chloride  (ISO)
N,N-diethyl-m-toluamide  (EXP)
nickel sulfate  (ISO)
okadaic acid  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
permethrin  (EXP)
potassium chromate  (ISO)
rac-lactic acid  (ISO)
scopolamine  (EXP)
sodium arsenite  (ISO)
sunitinib  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
tetraphene  (ISO)
triptonide  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function
microtubule binding  (IBA,IEA,ISO,ISS)
protein binding  (ISO)
tubulin binding  (IEA,ISO,ISS)

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. The neuroanatomy of Eml1 knockout mice, a model of subcortical heterotopia. Collins SC, etal., J Anat. 2019 Sep;235(3):637-650. doi: 10.1111/joa.13013. Epub 2019 Jun 7.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. A deletion in Eml1 leads to bilateral subcortical heterotopia in the tish rat. Grosenbaugh DK, etal., Neurobiol Dis. 2020 Jul;140:104836. doi: 10.1016/j.nbd.2020.104836. Epub 2020 Mar 13.
4. Genetic variants of EML1 and HIST1H4E in myeloid cell-related pathway genes independently predict cutaneous melanoma-specific survival. He Y, etal., Am J Cancer Res. 2021 Jun 15;11(6):3252-3262. eCollection 2021.
5. Mutations in Eml1 lead to ectopic progenitors and neuronal heterotopia in mouse and human. Kielar M, etal., Nat Neurosci. 2014 Jul;17(7):923-33. doi: 10.1038/nn.3729. Epub 2014 May 25.
6. A genetic animal model of human neocortical heterotopia associated with seizures. Lee KS, etal., J Neurosci. 1997 Aug 15;17(16):6236-42. doi: 10.1523/JNEUROSCI.17-16-06236.1997.
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:24029230   PMID:24625528   PMID:24706829   PMID:38897390  


Genomics

Comparative Map Data
Eml1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86133,048,271 - 133,221,642 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl6133,048,427 - 133,221,642 (+)EnsemblGRCr8
mRatBN7.26127,283,968 - 127,457,246 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6127,284,029 - 127,457,246 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx6127,408,913 - 127,581,347 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06127,703,970 - 127,876,401 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06127,061,846 - 127,234,628 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.06132,367,342 - 132,450,488 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6132,383,337 - 132,450,393 (+)Ensemblrn6Rnor6.0
Rnor_5.06141,536,753 - 141,619,726 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.46132,825,590 - 132,880,169 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera6124,926,667 - 125,013,010 (+)NCBICelera
RGSC_v3.16132,831,776 - 132,886,352 (+)NCBI
Cytogenetic Map6q32NCBI
EML1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381499,737,722 - 99,942,060 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1499,737,693 - 99,942,060 (+)Ensemblhg38GRCh38
GRCh3714100,204,059 - 100,408,397 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361499,329,498 - 99,478,150 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341499,329,497 - 99,478,146NCBI
Celera1480,314,618 - 80,463,271 (+)NCBICelera
Cytogenetic Map14q32.2NCBI
HuRef1480,500,729 - 80,591,998 (+)NCBIHuRef
CHM1_114100,197,512 - 100,346,159 (+)NCBICHM1_1
T2T-CHM13v2.01493,969,151 - 94,174,609 (+)NCBIT2T-CHM13v2.0
Eml1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3912108,337,265 - 108,505,835 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl12108,337,216 - 108,505,876 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm3812108,371,002 - 108,539,576 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12108,370,957 - 108,539,617 (+)Ensemblmm10GRCm38
MGSCv3712109,648,865 - 109,777,774 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3612108,818,764 - 108,987,383 (+)NCBIMGSCv36mm8
MGSCv3612102,632,098 - 102,805,540 (+)NCBIMGSCv36mm8
Celera12109,653,344 - 109,775,028 (+)NCBICelera
Cytogenetic Map12F1NCBI
cM Map1259.46NCBI
Eml1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543821,078,760 - 21,137,926 (+)Ensembl
ChiLan1.0NW_00495543820,991,432 - 21,137,570 (+)NCBIChiLan1.0ChiLan1.0
EML1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v215100,893,344 - 101,097,011 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan114100,109,839 - 100,313,506 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01480,362,837 - 80,566,996 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11499,717,220 - 99,885,359 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1499,793,812 - 99,885,359 (+)EnsemblpanPan2panpan1.1
EML1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1868,139,741 - 68,295,363 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl868,216,857 - 68,294,080 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha867,628,246 - 67,816,902 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0868,391,782 - 68,580,690 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl868,391,815 - 68,580,640 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1868,052,800 - 68,241,854 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0868,119,216 - 68,308,068 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0868,516,950 - 68,705,827 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Eml1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244086406,420,280 - 6,584,031 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366043,498,304 - 3,662,244 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366043,498,413 - 3,662,188 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EML1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl7120,703,258 - 120,890,791 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.17120,703,282 - 120,890,792 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
EML1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12477,694,931 - 77,907,574 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2477,694,971 - 77,907,909 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605364,834,630 - 65,042,702 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Eml1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247344,089,986 - 4,236,776 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247344,090,077 - 4,150,706 (-)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Eml1
8363 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:268
Count of miRNA genes:91
Interacting mature miRNAs:98
Transcripts:ENSRNOT00000066611, ENSRNOT00000071733, ENSRNOT00000071863
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4145118Mcs26Mammary carcinoma susceptibility QTL 260.0001mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)6112483610147156653Rat
1331797Bp213Blood pressure QTL 2133.291arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)6114241077147156653Rat
2293088Iddm28Insulin dependent diabetes mellitus QTL 285.21blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)668767270135411972Rat
1331799Bp211Blood pressure QTL 2113.66407arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)688019181136741135Rat
10054138Gmadr3Adrenal mass QTL 33.680.00045adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)690871046135871046Rat
1581563Uae33Urinary albumin excretion QTL 33urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)693560258136550638Rat
1641917Colcr5Colorectal carcinoma resistance QTL 53.180.0009intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)698944780143944780Rat
61414Pia3Pristane induced arthritis QTL 34.5joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)6100704576136029228Rat
71111Iddm8Insulin dependent diabetes mellitus QTL 81.90.002blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)6110921244147156653Rat
724524Uae2Urinary albumin excretion QTL 22.70.0005urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)679198463144254945Rat
1358355Srcrt4Stress Responsive Cort QTL 46.39blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)6106095977147156653Rat
2303624Vencon5Ventilatory control QTL 54.45respiration trait (VT:0001943)minute ventilation (CMO:0000132)693778632138778632Rat
10054123Srcrt6Stress Responsive Cort QTL 62.50.0043blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)690871046135871046Rat
724536Uae7Urinary albumin excretion QTL 73.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)693560258136550638Rat
737976Pia24Pristane induced arthritis QTL 24joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)6118366855147156653Rat
2312560Pur20Proteinuria QTL 202.10.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)6131392689143944780Rat
2313399Anxrr28Anxiety related response QTL 28aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)6101593607138161926Rat
1298087Iddm18Insulin dependent diabetes mellitus QTL 180.0001urine glucose amount (VT:0001758)percentage of study population developing diabetes mellitus during a period of time (CMO:0001114)6122236101147156653Rat
1581550Pur8Proteinuria QTL 8urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)693560258136550638Rat
12801471Schws9Schwannoma susceptibility QTL 9nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)6101593607146593607Rat
2293085Iddm29Insulin dependent diabetes mellitus QTL 297.66blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)6121444670147156653Rat

Markers in Region
BF409188  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26127,363,119 - 127,363,238 (+)MAPPERmRatBN7.2
Rnor_6.06132,361,194 - 132,361,312NCBIRnor6.0
Rnor_5.06141,530,620 - 141,530,738UniSTSRnor5.0
RGSC_v3.46132,819,396 - 132,819,514UniSTSRGSC3.4
Celera6124,920,892 - 124,921,010UniSTS
RH 3.4 Map6796.4UniSTS
Cytogenetic Map6q32UniSTS
BM390550  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26127,304,943 - 127,305,163 (+)MAPPERmRatBN7.2
Rnor_6.06132,303,846 - 132,304,065NCBIRnor6.0
Rnor_5.06141,473,785 - 141,474,004UniSTSRnor5.0
RGSC_v3.46132,762,243 - 132,762,462UniSTSRGSC3.4
Celera6124,863,617 - 124,863,836UniSTS
RH 3.4 Map6791.5UniSTS
Cytogenetic Map6q32UniSTS


Genetic Models
This gene Eml1 is modified in the following models/strains:
SD-Eml1tish/Scrb    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 163 91 90 59 78 59 6 342 178 11 142 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001025741 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001399709 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001399710 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001399711 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001399712 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_174190 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_174191 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039112546 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039112547 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039112550 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039112551 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039112552 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039112553 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063262135 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide BC097450 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474034 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000071733   ⟹   ENSRNOP00000067418
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl6133,133,620 - 133,221,628 (+)Ensembl
mRatBN7.2 Ensembl6127,385,187 - 127,455,903 (+)Ensembl
Rnor_6.0 Ensembl6132,383,337 - 132,450,393 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000071863   ⟹   ENSRNOP00000067636
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl6133,048,427 - 133,220,299 (+)Ensembl
mRatBN7.2 Ensembl6127,284,029 - 127,455,903 (+)Ensembl
Rnor_6.0 Ensembl6132,383,370 - 132,450,393 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000107380   ⟹   ENSRNOP00000085896
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl6133,048,427 - 133,221,639 (+)Ensembl
mRatBN7.2 Ensembl6127,284,029 - 127,457,235 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000108825   ⟹   ENSRNOP00000097362
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl6133,105,934 - 133,221,642 (+)Ensembl
mRatBN7.2 Ensembl6127,284,075 - 127,457,246 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000114172   ⟹   ENSRNOP00000090244
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl6133,105,902 - 133,221,629 (+)Ensembl
mRatBN7.2 Ensembl6127,341,559 - 127,457,235 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000118546   ⟹   ENSRNOP00000096898
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl6133,048,430 - 133,221,642 (+)Ensembl
mRatBN7.2 Ensembl6127,284,083 - 127,457,245 (+)Ensembl
RefSeq Acc Id: NM_001025741   ⟹   NP_001020912
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86133,133,659 - 133,221,642 (+)NCBI
mRatBN7.26127,369,259 - 127,457,246 (+)NCBI
Rnor_6.06132,367,342 - 132,450,488 (+)NCBI
Rnor_5.06141,536,753 - 141,619,726 (+)NCBI
RGSC_v3.46132,825,590 - 132,880,169 (+)RGD
Celera6124,926,667 - 125,013,010 (+)RGD
Sequence:
RefSeq Acc Id: NM_001399709   ⟹   NP_001386638
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86133,048,430 - 133,221,642 (+)NCBI
mRatBN7.26127,284,024 - 127,457,246 (+)NCBI
RefSeq Acc Id: NM_001399710   ⟹   NP_001386639
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86133,105,934 - 133,221,642 (+)NCBI
mRatBN7.26127,341,530 - 127,457,246 (+)NCBI
RefSeq Acc Id: NM_001399711   ⟹   NP_001386640
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86133,105,934 - 133,221,642 (+)NCBI
mRatBN7.26127,341,530 - 127,457,246 (+)NCBI
RefSeq Acc Id: NM_001399712   ⟹   NP_001386641
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86133,048,430 - 133,221,642 (+)NCBI
mRatBN7.26127,284,024 - 127,457,246 (+)NCBI
RefSeq Acc Id: NR_174190
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86133,048,430 - 133,221,642 (+)NCBI
mRatBN7.26127,284,024 - 127,457,246 (+)NCBI
RefSeq Acc Id: NR_174191
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86133,105,934 - 133,221,642 (+)NCBI
mRatBN7.26127,341,530 - 127,457,246 (+)NCBI
RefSeq Acc Id: XM_039112546   ⟹   XP_038968474
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86133,105,856 - 133,221,631 (+)NCBI
mRatBN7.26127,341,396 - 127,457,246 (+)NCBI
RefSeq Acc Id: XM_039112547   ⟹   XP_038968475
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86133,048,271 - 133,221,631 (+)NCBI
mRatBN7.26127,283,968 - 127,457,246 (+)NCBI
RefSeq Acc Id: XM_039112550   ⟹   XP_038968478
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86133,133,617 - 133,221,631 (+)NCBI
mRatBN7.26127,369,216 - 127,457,246 (+)NCBI
RefSeq Acc Id: XM_039112551   ⟹   XP_038968479
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86133,091,524 - 133,221,631 (+)NCBI
mRatBN7.26127,327,111 - 127,457,246 (+)NCBI
RefSeq Acc Id: XM_039112552   ⟹   XP_038968480
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86133,181,394 - 133,221,631 (+)NCBI
mRatBN7.26127,416,984 - 127,457,246 (+)NCBI
RefSeq Acc Id: XM_039112553   ⟹   XP_038968481
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86133,181,394 - 133,221,631 (+)NCBI
mRatBN7.26127,416,984 - 127,457,235 (+)NCBI
RefSeq Acc Id: XM_063262135   ⟹   XP_063118205
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86133,091,777 - 133,221,631 (+)NCBI
RefSeq Acc Id: NP_001020912   ⟸   NM_001025741
- Peptide Label: isoform 5
- UniProtKB: A0A8I6ASI8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000067636   ⟸   ENSRNOT00000071863
Ensembl Acc Id: ENSRNOP00000067418   ⟸   ENSRNOT00000071733
RefSeq Acc Id: XP_038968475   ⟸   XM_039112547
- Peptide Label: isoform X2
- UniProtKB: A0A8I6A157 (UniProtKB/TrEMBL),   A0A8I6ASI8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038968479   ⟸   XM_039112551
- Peptide Label: isoform X3
- UniProtKB: A0A8I6ASI8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038968474   ⟸   XM_039112546
- Peptide Label: isoform X1
- UniProtKB: A0A8I6AD94 (UniProtKB/TrEMBL),   A0A8I6ASI8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038968478   ⟸   XM_039112550
- Peptide Label: isoform X3
- UniProtKB: A0A8I6ASI8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038968480   ⟸   XM_039112552
- Peptide Label: isoform X5
- UniProtKB: A6KBG3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038968481   ⟸   XM_039112553
- Peptide Label: isoform X6
- UniProtKB: A6KBG3 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000085896   ⟸   ENSRNOT00000107380
Ensembl Acc Id: ENSRNOP00000096898   ⟸   ENSRNOT00000118546
Ensembl Acc Id: ENSRNOP00000090244   ⟸   ENSRNOT00000114172
Ensembl Acc Id: ENSRNOP00000097362   ⟸   ENSRNOT00000108825
RefSeq Acc Id: NP_001386638   ⟸   NM_001399709
- Peptide Label: isoform 1
- UniProtKB: A0A8I6AVR0 (UniProtKB/TrEMBL),   A0A8I6ASI8 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001386641   ⟸   NM_001399712
- Peptide Label: isoform 4
- UniProtKB: A0A8I6ASI8 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001386640   ⟸   NM_001399711
- Peptide Label: isoform 3
- UniProtKB: Q4V8C3 (UniProtKB/Swiss-Prot),   A0A8I6ASI8 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001386639   ⟸   NM_001399710
- Peptide Label: isoform 2
- UniProtKB: A0A8I6ASI8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063118205   ⟸   XM_063262135
- Peptide Label: isoform X4
- UniProtKB: A0A8I6ASI8 (UniProtKB/TrEMBL)
Protein Domains
Echinoderm microtubule-associated protein-like first   EML-like second beta-propeller

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q4V8C3-F1-model_v2 AlphaFold Q4V8C3 1-814 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1306374 AgrOrtholog
BioCyc Gene G2FUF-36298 BioCyc
Ensembl Genes ENSRNOG00000043143 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000071733 ENTREZGENE
  ENSRNOT00000107380 ENTREZGENE
  ENSRNOT00000108825 ENTREZGENE
  ENSRNOT00000114172 ENTREZGENE
  ENSRNOT00000118546 ENTREZGENE
Gene3D-CATH 2.130.10.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7456735 IMAGE-MGC_LOAD
InterPro Beta-prop_EML-like_2nd UniProtKB/Swiss-Prot
  Beta-prop_EML_1st UniProtKB/Swiss-Prot
  HELP UniProtKB/Swiss-Prot
  Quinoprotein_ADH-like_supfam UniProtKB/Swiss-Prot
  WD40/YVTN_repeat-like_dom_sf UniProtKB/Swiss-Prot
  WD40_repeat UniProtKB/Swiss-Prot
  WD40_repeat_dom_sf UniProtKB/Swiss-Prot
  WD_repeat_EMAP UniProtKB/Swiss-Prot
KEGG Report rno:362783 UniProtKB/Swiss-Prot
MGC_CLONE MGC:114510 IMAGE-MGC_LOAD
NCBI Gene 362783 ENTREZGENE
PANTHER ECHINODERM MICROTUBULE-ASSOCIATED PROTEIN-LIKE 1 UniProtKB/Swiss-Prot
  WD-40 REPEAT PROTEIN UniProtKB/Swiss-Prot
Pfam Beta-prop_EML UniProtKB/Swiss-Prot
  Beta-prop_EML_2 UniProtKB/Swiss-Prot
  HELP UniProtKB/Swiss-Prot
PhenoGen Eml1 PhenoGen
PROSITE WD_REPEATS_1 UniProtKB/Swiss-Prot
  WD_REPEATS_2 UniProtKB/Swiss-Prot
  WD_REPEATS_REGION UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000043143 RatGTEx
SMART WD40 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF50978 UniProtKB/Swiss-Prot
  SSF50998 UniProtKB/Swiss-Prot
UniProt A0A8I6A157 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AD94 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6ASI8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AVR0 ENTREZGENE, UniProtKB/TrEMBL
  A6KBG1_RAT UniProtKB/TrEMBL
  A6KBG2_RAT UniProtKB/TrEMBL
  A6KBG3 ENTREZGENE, UniProtKB/TrEMBL
  EMAL1_RAT UniProtKB/Swiss-Prot
  M0RCT5_RAT UniProtKB/TrEMBL
  M0RDD8_RAT UniProtKB/TrEMBL
  Q4V8C3 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-12-04 Eml1  EMAP like 1  Eml1  echinoderm microtubule associated protein like 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Eml1  echinoderm microtubule associated protein like 1  Eml1_predicted  echinoderm microtubule associated protein like 1 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Eml1_predicted  echinoderm microtubule associated protein like 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED