Nod2 (nucleotide-binding oligomerization domain containing 2) - Rat Genome Database

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Gene: Nod2 (nucleotide-binding oligomerization domain containing 2) Rattus norvegicus
Symbol: Nod2
Name: nucleotide-binding oligomerization domain containing 2
RGD ID: 1306368
Description: Enables muramyl dipeptide binding activity. Involved in several processes, including cellular response to peptidoglycan; positive regulation of dendritic cell cytokine production; and response to muramyl dipeptide. Predicted to be located in several cellular components, including Golgi apparatus; basolateral plasma membrane; and phagocytic vesicle. Predicted to be part of protein-containing complex. Predicted to be active in cytosol and plasma membrane. Predicted to be extrinsic component of plasma membrane. Biomarker of colitis; middle cerebral artery infarction; and pancreatitis. Human ortholog(s) of this gene implicated in several diseases, including Blau syndrome; autoimmune disease (multiple); gastrointestinal carcinoma; intestinal disease (multiple); and lung disease (multiple). Orthologous to human NOD2 (nucleotide binding oligomerization domain containing 2); PARTICIPATES IN NOD-like receptor signaling pathway; nuclear factor kappa B signaling pathway; tuberculosis pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4,6-trinitrobenzenesulfonic acid; 4,4'-sulfonyldiphenol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Card15; caspase recruitment domain family, member 15; LOC291912; nucleotide-binding oligomerization domain-containing protein 2
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr81934,555,832 - 34,596,281 (-)NCBIGRCr8
mRatBN7.21918,382,369 - 18,422,817 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1918,382,439 - 18,417,177 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1920,062,002 - 20,096,735 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01925,256,605 - 25,291,343 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01928,214,380 - 28,249,133 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01919,342,061 - 19,389,366 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1919,332,594 - 19,377,492 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01930,375,065 - 30,409,527 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41919,662,337 - 19,697,341 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11919,670,606 - 19,715,845 (-)NCBI
Celera1918,269,940 - 18,304,004 (-)NCBICelera
Cytogenetic Map19p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View
acne  (ISO)
Acute Lung Injury  (IDA)
allergic rhinitis  (ISO)
asthma  (ISO)
atherosclerosis  (ISO)
autoimmune disease  (ISO)
Bacteremia  (ISO)
bacterial infectious disease  (ISO)
bacterial pneumonia  (ISO)
Behcet's disease  (ISO)
Blau syndrome  (ISO)
breast cancer  (ISO)
bronchiolitis obliterans  (ISO)
Chediak-Higashi syndrome  (ISO)
chronic obstructive pulmonary disease  (ISO)
colitis  (IEP,ISO)
Colonic Neoplasms  (ISO)
colorectal adenocarcinoma  (ISO)
coronary artery disease  (ISO)
Crohn's disease  (ISO)
dermatitis  (ISO)
Experimental Arthritis  (ISO)
Experimental Colitis  (IEP)
familial mediterranean fever  (ISO)
gastritis  (ISO)
gastrointestinal carcinoma  (ISO)
genetic disease  (ISO)
graft-versus-host disease  (ISO)
Granuloma  (ISO)
hidradenitis suppurativa  (ISO)
inflammatory bowel disease  (ISO)
inflammatory bowel disease 1  (ISO,ISS)
intestinal disease  (ISO)
larynx cancer  (ISO)
Legionnaires' disease  (ISO)
leprosy  (ISO)
lung cancer  (ISO)
Lyme disease  (ISO)
meningococcal meningitis  (ISO)
Metaplasia  (ISO)
middle cerebral artery infarction  (IEP)
nephronophthisis 14  (ISO)
Ocular Toxoplasmosis  (ISO)
ovarian cancer  (ISO)
pancreatitis  (IEP)
perinatal necrotizing enterocolitis  (ISO)
PFAPA Syndrome  (ISO)
Pneumococcal Meningitis  (ISO)
psoriatic arthritis  (ISO)
pulmonary sarcoidosis  (ISO)
pulmonary tuberculosis  (ISO)
pyoderma gangrenosum  (ISO)
relapsing-remitting multiple sclerosis  (ISO)
Reperfusion Injury  (IEP)
rhinitis  (ISO)
Seasonal Allergic Rhinitis  (ISO)
Sepsis  (IEP,ISO)
Splenomegaly  (ISO)
Staphylococcal Pneumonia  (ISO)
systemic lupus erythematosus  (ISO)
transient cerebral ischemia  (ISO)
ulcerative colitis  (ISO)
uveitis  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of immune response  (ISO)
adaptive immune response  (IEA)
antibacterial innate immune response  (ISO)
biosynthetic process of antibacterial peptides active against Gram-positive bacteria  (ISO)
cellular response to lipopolysaccharide  (ISO)
cellular response to muramyl dipeptide  (ISO)
cellular response to organic cyclic compound  (IEP)
cellular response to peptidoglycan  (IEP,ISO)
defense response to bacterium  (IBA,ISO)
defense response to Gram-positive bacterium  (ISO)
detection of bacterium  (ISO)
detection of muramyl dipeptide  (ISO)
ERK1 and ERK2 cascade  (ISO)
establishment of localization in cell  (ISO)
host-mediated regulation of intestinal microbiota composition  (ISO)
inflammatory response  (IEA)
innate immune response  (ISO)
innate immune response in mucosa  (ISO)
intestinal stem cell homeostasis  (ISO)
intracellular signal transduction  (IBA,ISO)
JNK cascade  (ISO)
maintenance of gastrointestinal epithelium  (ISO)
MAPK cascade  (ISO)
negative regulation of cellular defense response  (IEA)
negative regulation of inflammatory response to antigenic stimulus  (ISO)
negative regulation of interleukin-12 production  (ISO)
negative regulation of interleukin-18 production  (ISO)
negative regulation of interleukin-2 production  (ISO)
negative regulation of macrophage apoptotic process  (ISO)
negative regulation of macrophage cytokine production  (ISO)
negative regulation of T cell mediated immunity  (ISO)
negative regulation of toll-like receptor 2 signaling pathway  (ISO)
negative regulation of tumor necrosis factor production  (ISO)
negative regulation of type II interferon production  (ISO)
nucleotide-binding oligomerization domain containing 2 signaling pathway  (ISO)
pattern recognition receptor signaling pathway  (ISO)
phagocytosis  (ISO)
positive regulation of antibacterial peptide biosynthetic process  (ISO)
positive regulation of autophagy  (ISO)
positive regulation of B cell activation  (ISO)
positive regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria  (ISO)
positive regulation of canonical NF-kappaB signal transduction  (IBA,ISO)
positive regulation of cell population proliferation  (IDA)
positive regulation of cytokine production involved in immune response  (ISO)
positive regulation of cytokine production involved in inflammatory response  (ISO)
positive regulation of dendritic cell antigen processing and presentation  (ISO)
positive regulation of dendritic cell cytokine production  (IDA)
positive regulation of epithelial cell proliferation  (ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of humoral immune response mediated by circulating immunoglobulin  (ISO)
positive regulation of innate immune response  (ISO)
positive regulation of interleukin-1 beta production  (ISO)
positive regulation of interleukin-10 production  (ISO)
positive regulation of interleukin-12 production  (ISO)
positive regulation of interleukin-17 production  (ISO)
positive regulation of interleukin-6 production  (ISO)
positive regulation of interleukin-8 production  (ISO)
positive regulation of JNK cascade  (ISO)
positive regulation of macrophage cytokine production  (ISO)
positive regulation of MAPK cascade  (ISO)
positive regulation of mitophagy  (ISO)
positive regulation of monocyte chemotactic protein-1 production  (ISO)
positive regulation of nitric-oxide synthase biosynthetic process  (ISO)
positive regulation of non-canonical NF-kappaB signal transduction  (ISO)
positive regulation of Notch signaling pathway  (ISO)
positive regulation of peptidyl-tyrosine phosphorylation  (ISO)
positive regulation of phagocytosis  (ISO)
positive regulation of protein K63-linked ubiquitination  (ISO)
positive regulation of protein ubiquitination  (ISO)
positive regulation of pyroptosis  (IEA)
positive regulation of stress-activated MAPK cascade  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of tumor necrosis factor production  (ISO)
positive regulation of type 2 immune response  (ISO)
positive regulation of xenophagy  (ISO)
regulation of appetite  (ISO)
regulation of inflammatory response  (ISO)
regulation of neutrophil chemotaxis  (ISO)
response to endoplasmic reticulum stress  (ISO)
response to exogenous dsRNA  (ISO)
response to lipopolysaccharide  (ISO)
response to muramyl dipeptide  (IBA,IDA,ISO)
response to nutrient  (IEP)
response to peptidoglycan  (ISO)
stress-activated MAPK cascade  (ISO)
temperature homeostasis  (ISO)
toll-like receptor 2 signaling pathway  (ISO)
xenophagy  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View

References - curated
# Reference Title Reference Citation
1. Common nonsynonymous polymorphisms in the NOD2 gene are associated with resistance or susceptibility to tuberculosis disease in African Americans. Austin CM, etal., J Infect Dis. 2008 Jun 15;197(12):1713-6.
2. Protective effect of naringenin in experimental ischemic stroke: down-regulated NOD2, RIP2, NF-¿B, MMP-9 and up-regulated claudin-5 expression. Bai X, etal., Neurochem Res. 2014 Aug;39(8):1405-15. doi: 10.1007/s11064-014-1326-y. Epub 2014 May 20.
3. NOD2/CARD15 gene mutations in patients with familial Mediterranean fever. Berkun Y, etal., Semin Arthritis Rheum. 2012 Aug;42(1):84-8. doi: 10.1016/j.semarthrit.2011.12.002. Epub 2012 Jan 12.
4. Common polymorphisms in the NOD2 gene region are associated with leprosy and its reactive states. Berrington WR, etal., J Infect Dis. 2010 May 1;201(9):1422-35.
5. Induction and rescue of Nod2-dependent Th1-driven granulomatous inflammation of the ileum. Biswas A, etal., Proc Natl Acad Sci U S A. 2010 Aug 17;107(33):14739-44. Epub 2010 Aug 2.
6. NOD2 receptors in adenopituitary folliculostellate cells: expression and function. Correa-de-Santana E, etal., J Endocrinol. 2009 Oct;203(1):111-22. Epub 2009 Jul 16.
7. The role of inflammatory bowel disease susceptibility loci in multiple sclerosis and systemic lupus erythematosus. De Jager PL, etal., Genes Immun. 2006 Jun;7(4):327-34. Epub 2006 Apr 27.
8. Innate signals from Nod2 block respiratory tolerance and program T(H)2-driven allergic inflammation. Duan W, etal., J Allergy Clin Immunol. 2010 Dec;126(6):1284-93.e10. Epub 2010 Nov 4.
9. Association of a NOD2 gene polymorphism and T-helper 17 cells with presumed ocular toxoplasmosis. Dutra MS, etal., J Infect Dis. 2013 Jan 1;207(1):152-63. doi: 10.1093/infdis/jis640. Epub 2012 Oct 24.
10. Polymorphisms of innate pattern recognition receptors, response to interferon-beta and development of neutralizing antibodies in multiple sclerosis patients. Enevold C, etal., Mult Scler. 2010 Aug;16(8):942-9. doi: 10.1177/1352458510373264. Epub 2010 Jul 1.
11. Anti-inflammatory capacity of selected lactobacilli in experimental colitis is driven by NOD2-mediated recognition of a specific peptidoglycan-derived muropeptide. Fernandez EM, etal., Gut. 2011 Aug;60(8):1050-9. Epub 2011 Apr 6.
12. The pattern recognition receptors Nod1 and Nod2 account for neutrophil recruitment to the lungs of mice infected with Legionella pneumophila. Frutuoso MS, etal., Microbes Infect. 2010 Oct;12(11):819-27. Epub 2010 Jun 2.
13. Identification of Card15/Nod2 mRNA in intestinal tissue of experimentally induced colitis in rats. Fujisawa M, etal., J Vet Med Sci. 2006 Jul;68(7):701-8.
14. Association between NOD2/CARD15 polymorphisms and coronary artery disease: a case-control study. Galluzzo S, etal., Hum Immunol. 2011 Aug;72(8):636-40. Epub 2011 Apr 29.
15. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
16. Nod1 and Nod2 regulation of inflammation in the Salmonella colitis model. Geddes K, etal., Infect Immun. 2010 Dec;78(12):5107-15. Epub 2010 Oct 4.
17. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
18. Combinations of TLR and NOD2 ligands stimulate rat microglial P2X4R expression. Guo LH, etal., Biochem Biophys Res Commun. 2006 Oct 27;349(3):1156-62. Epub 2006 Sep 1.
19. Total parenteral-nutrition-mediated dendritic-cell activation and infiltration into the small intestine in a rat model. Hagiwara S, etal., J Anesth. 2011 Feb;25(1):57-64. Epub 2010 Nov 6.
20. Dendritic cell activation in response to ischemia-reperfusion injury of the small intestine. Hagiwara S, etal., Surg Today. 2010;40(2):137-45. Epub 2010 Jan 28.
21. Recipient NOD2/CARD15 variants: a novel independent risk factor for the development of bronchiolitis obliterans after allogeneic stem cell transplantation. Hildebrandt GC, etal., Biol Blood Marrow Transplant. 2008 Jan;14(1):67-74.
22. Association of c.802C>T polymorphism of NOD2/CARD15 gene with the chronic gastritis and predisposition to cancer in H. pylori infected patients. Hnatyszyn A, etal., Exp Mol Pathol. 2010 Jun;88(3):388-93. Epub 2010 Mar 15.
23. Both donor and recipient NOD2/CARD15 mutations associate with transplant-related mortality and GvHD following allogeneic stem cell transplantation. Holler E, etal., Blood. 2004 Aug 1;104(3):889-94. Epub 2004 Apr 15.
24. [The expression of NOD1 and NOD2 and the regulation of glucocorticoids on them in allergic rhinitis]. Hu S, etal., Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2013 Apr;27(8):393-6.
25. Differential pattern recognition receptor expression but stereotyped responsiveness in rat spleen dendritic cell subsets. Hubert FX, etal., J Immunol. 2006 Jul 15;177(2):1007-16.
26. Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease. Hugot JP, etal., Nature. 2001 May 31;411(6837):599-603.
27. Association between polymorphisms in caspase recruitment domain containing protein 15 and allergy in two German populations. Kabesch M, etal., J Allergy Clin Immunol. 2003 Apr;111(4):813-7.
28. Impact of Genetic Variation in MicroRNA-binding Site on Susceptibility to Colorectal Cancer. Kang BW, etal., Anticancer Res. 2016 Jul;36(7):3353-61.
29. Contribution of NOD2 to lung inflammation during Staphylococcus aureus-induced pneumonia. Kapetanovic R, etal., Microbes Infect. 2010 Sep;12(10):759-67. Epub 2010 May 21.
30. Low prevalence of NOD2 SNPs in Behcet's disease suggests protective association in Caucasians. Kappen JH, etal., Rheumatology (Oxford). 2009 Nov;48(11):1375-7. doi: 10.1093/rheumatology/kep292. Epub 2009 Sep 11.
31. Viral infection augments Nod1/2 signaling to potentiate lethality associated with secondary bacterial infections. Kim YG, etal., Cell Host Microbe. 2011 Jun 16;9(6):496-507.
32. A NOD2 gene polymorphism is associated with the prevalence and severity of chronic obstructive pulmonary disease in a Japanese population. Kinose D, etal., Respirology. 2011 Sep 22. doi: 10.1111/j.1440-1843.2011.02069.x.
33. Prevalence of the NOD2 3020insC mutation in aggregations of breast and lung cancer. Lener MR, etal., Breast Cancer Res Treat. 2006 Jan;95(2):141-5.
34. Comprehensive study of baicalin down-regulating NOD2 receptor expression of neurons with oxygen-glucose deprivation in vitro and cerebral ischemia-reperfusion in vivo. Li H, etal., Eur J Pharmacol. 2010 Dec 15;649(1-3):92-9. Epub 2010 Sep 20.
35. Analysis of nucleotide-binding oligomerization domain proteins in a murine model of pneumococcal meningitis. Liu X, etal., BMC Infect Dis. 2014 Dec 2;14(1):648.
36. The 3020insC Allele of NOD2 Predisposes to Cancers of Multiple Organs. Lubinski J, etal., Hered Cancer Clin Pract. 2005 Mar 15;3(2):59-63.
37. Common variants in NOD2 and IL23R are not associated with inflammatory bowel disease in Indians. Mahurkar S, etal., J Gastroenterol Hepatol. 2011 Apr;26(4):694-9. doi: 10.1111/j.1440-1746.2010.06533.x.
38. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
39. CARD15 mutations in Blau syndrome. Miceli-Richard C, etal., Nat Genet. 2001 Sep;29(1):19-20.
40. Activation of NOD2/RIPK2 pathway induces mitochondrial injury to oligodendrocyte precursor cells in vitro and CNS demyelination in vivo. Natarajan C, etal., J Neuroimmunol. 2013 Dec 15;265(1-2):51-60. doi: 10.1016/j.jneuroim.2013.09.009. Epub 2013 Oct 9.
41. Role of the NOD2 genotype in the clinical phenotype of Blau syndrome and early-onset sarcoidosis. Okafuji I, etal., Arthritis Rheum. 2009 Jan;60(1):242-50. doi: 10.1002/art.24134.
42. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
43. Nucleotide-binding oligomerization domain proteins are innate immune receptors for internalized Streptococcus pneumoniae. Opitz B, etal., J Biol Chem. 2004 Aug 27;279(35):36426-32. Epub 2004 Jun 23.
44. Significance of mannose-binding lectin deficiency and nucleotide-binding oligomerization domain 2 polymorphisms in Staphylococcus aureus bloodstream infections: a case-control study. Osthoff M, etal., PLoS One. 2013 Sep 27;8(9):e76218. doi: 10.1371/journal.pone.0076218. eCollection 2013.
45. NOD2 polymorphisms in clinical phenotypes of common variable immunodeficiency disorders. Packwood K, etal., Clin Exp Immunol. 2010 Sep;161(3):536-41. doi: 10.1111/j.1365-2249.2010.04216.x.
46. Effects of ghrelin on pulmonary NOD2 mRNA expression and NF-kappaB activation when protects against acute lung injury in rats challenged with cecal ligation and puncture. Peng Z, etal., Int Immunopharmacol. 2012 Aug;13(4):440-5. doi: 10.1016/j.intimp.2012.04.006. Epub 2012 May 7.
47. Nod2 suppresses Borrelia burgdorferi mediated murine Lyme arthritis and carditis through the induction of tolerance. Petnicki-Ocwieja T, etal., PLoS One. 2011 Feb 28;6(2):e17414.
48. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
49. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
50. Expression of NOD2 in a rat model of acute pancreatitis. Qian M, etal., Pancreas. 2010 Oct;39(7):1034-40.
51. GOA pipeline RGD automated data pipeline
52. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
53. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
54. Comprehensive gene review and curation RGD comprehensive gene curation
55. Nucleotide-binding oligomerization domain-2 inhibits toll-like receptor-4 signaling in the intestinal epithelium. Richardson WM, etal., Gastroenterology. 2010 Sep;139(3):904-17, 917.e1-6. doi: 10.1053/j.gastro.2010.05.038. Epub 2010 May 24.
56. Deep resequencing of GWAS loci identifies independent rare variants associated with inflammatory bowel disease. Rivas MA, etal., Nat Genet. 2011 Oct 9. doi: 10.1038/ng.952.
57. NOD2-associated pediatric granulomatous arthritis, an expanding phenotype: study of an international registry and a national cohort in Spain. Rose CD, etal., Arthritis Rheum. 2009 Jun;60(6):1797-803. doi: 10.1002/art.24533.
58. Nucleotide-binding oligomerization domain 2 and Toll-like receptor 2 function independently in a murine model of arthritis triggered by intraarticular peptidoglycan. Rosenzweig HL, etal., Arthritis Rheum. 2010 Apr;62(4):1051-9. doi: 10.1002/art.27335.
59. Dectin-1 and NOD2 mediate cathepsin activation in zymosan-induced arthritis in mice. Rosenzweig HL, etal., Inflamm Res. 2011 Jul;60(7):705-14. Epub 2011 Mar 20.
60. NOD2 deficiency results in increased susceptibility to peptidoglycan-induced uveitis in mice. Rosenzweig HL, etal., Invest Ophthalmol Vis Sci. 2011 Jun 9;52(7):4106-12. Print 2011 Jun.
61. CARD15/NOD2 polymorphisms are associated with severe pulmonary sarcoidosis. Sato H, etal., Eur Respir J. 2010 Feb;35(2):324-30. Epub 2009 Aug 13.
62. The NOD/RIP2 pathway is essential for host defenses against Chlamydophila pneumoniae lung infection. Shimada K, etal., PLoS Pathog. 2009 Apr;5(4):e1000379. Epub 2009 Apr 10.
63. TLR and NOD2 ligands induce cell proliferation in the rat intact spinal cord. Su Y, etal., J Neuropathol Exp Neurol. 2005 Nov;64(11):991-7.
64. [Study on protective mechanism of kushenin injection on colonic mucosa of experimental colitis rats]. Tang Q, etal., Zhongguo Zhong Yao Za Zhi. 2012 Jun;37(12):1814-7.
65. Importance of NOD2/CARD15 gene variants for susceptibility to and outcome of sepsis in Turkish children. Tekin D, etal., Pediatr Crit Care Med. 2011 Mar 31.
66. Common Crohn's disease-predisposing variants of the CARD15/NOD2 gene are not associated with Behçet's disease in Turkey. Uyar FA, etal., Clin Exp Rheumatol. 2004 Jul-Aug;22(4 Suppl 34):S50-2.
67. A new CARD15 mutation in Blau syndrome. van Duist MM, etal., Eur J Hum Genet. 2005 Jun;13(6):742-7.
68. Single nucleotide polymorphisms in pathogen recognition receptor genes are associated with susceptibility to meningococcal meningitis in a pediatric cohort. van Well GT, etal., PLoS One. 2013 May 14;8(5):e64252. doi: 10.1371/journal.pone.0064252. Print 2013.
69. Association of CARD15 polymorphisms with atopy-related traits in a population-based cohort of Caucasian adults. Weidinger S, etal., Clin Exp Allergy. 2005 Jul;35(7):866-72.
70. [Effect mechanism of NOD like receptor signaling pathway on intestinal mucosal barrier of rat during early phase of acute intra-abdominal infection]. Xiao YT, etal., Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2013 Sep;25(9):527-32. doi: 10.3760/cma.j.issn.2095-4352.2013.09.005.
71. A new category of autoinflammatory disease associated with NOD2 gene mutations. Yao Q, etal., Arthritis Res Ther. 2011;13(5):R148. doi: 10.1186/ar3462. Epub 2011 Sep 14.
72. Down-Regulated NOD2 by Immunosuppressants in Peripheral Blood Cells in Patients with SLE Reduces the Muramyl Dipeptide-Induced IL-10 Production. Yu SL, etal., PLoS One. 2011;6(8):e23855. Epub 2011 Aug 19.
73. Pivotal role of NOD2 in inflammatory processes affecting atherosclerosis and periodontal bone loss. Yuan H, etal., Proc Natl Acad Sci U S A. 2013 Dec 24;110(52):E5059-68. doi: 10.1073/pnas.1320862110. Epub 2013 Dec 9.
Additional References at PubMed
PMID:11087742   PMID:11385577   PMID:12527755   PMID:14560001   PMID:15075345   PMID:15107016   PMID:15220916   PMID:15620648   PMID:15653568   PMID:15692051   PMID:15753091   PMID:15998797  
PMID:16203728   PMID:16260731   PMID:16414084   PMID:16714539   PMID:16949315   PMID:17058067   PMID:17187069   PMID:17337451   PMID:17919942   PMID:17971865   PMID:18167348   PMID:18261938  
PMID:18511561   PMID:18855982   PMID:19139201   PMID:19218085   PMID:20008287   PMID:20441518   PMID:20844241   PMID:20926588   PMID:21040358   PMID:21156799   PMID:21172192   PMID:21887730  
PMID:22033934   PMID:23806334   PMID:23892723   PMID:24671169   PMID:24790089   PMID:25093298   PMID:25502289   PMID:25528059   PMID:25891078   PMID:25990971   PMID:26138652   PMID:27812135  
PMID:29303910   PMID:29913461   PMID:31649195   PMID:33843019   PMID:35764993  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr81934,555,832 - 34,596,281 (-)NCBIGRCr8
mRatBN7.21918,382,369 - 18,422,817 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1918,382,439 - 18,417,177 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1920,062,002 - 20,096,735 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01925,256,605 - 25,291,343 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01928,214,380 - 28,249,133 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01919,342,061 - 19,389,366 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1919,332,594 - 19,377,492 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01930,375,065 - 30,409,527 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41919,662,337 - 19,697,341 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11919,670,606 - 19,715,845 (-)NCBI
Celera1918,269,940 - 18,304,004 (-)NCBICelera
Cytogenetic Map19p11NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381650,693,606 - 50,733,075 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1650,693,588 - 50,733,077 (+)EnsemblGRCh38hg38GRCh38
GRCh371650,727,517 - 50,766,986 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361649,288,551 - 49,324,488 (+)NCBINCBI36Build 36hg18NCBI36
Build 341649,288,550 - 49,324,488NCBI
Celera1635,246,377 - 35,282,313 (+)NCBICelera
Cytogenetic Map16q12.1NCBI
HuRef1636,618,016 - 36,653,950 (+)NCBIHuRef
CHM1_11652,138,579 - 52,174,513 (+)NCBICHM1_1
T2T-CHM13v2.01656,491,240 - 56,530,709 (+)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39889,373,943 - 89,415,103 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl889,373,943 - 89,415,102 (+)EnsemblGRCm39 Ensembl
GRCm38888,647,315 - 88,688,474 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl888,647,315 - 88,688,474 (+)EnsemblGRCm38mm10GRCm38
MGSCv37891,171,246 - 91,212,373 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36891,537,452 - 91,578,579 (+)NCBIMGSCv36mm8
Celera892,927,621 - 92,968,882 (+)NCBICelera
Cytogenetic Map8C3NCBI
cM Map843.51NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_0049554338,746,004 - 8,782,710 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554338,746,213 - 8,780,119 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan1-v21860,150,040 - 60,189,509 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11666,055,771 - 66,095,149 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01630,955,976 - 30,995,451 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11649,834,385 - 49,873,783 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1649,837,891 - 49,873,773 (+)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.1264,636,850 - 64,667,232 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl264,635,519 - 64,667,232 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha261,209,788 - 61,240,085 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0265,182,339 - 65,218,538 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl265,182,339 - 65,212,649 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1262,006,039 - 62,036,328 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0263,025,931 - 63,056,292 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0263,913,478 - 63,943,824 (-)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440934955,844,066 - 55,881,006 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364753,713,362 - 3,745,982 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364753,708,069 - 3,742,845 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl634,130,938 - 34,177,534 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1634,132,127 - 34,167,446 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.1536,492,158 - 36,531,766 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl536,496,414 - 36,530,499 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604739,970,704 - 40,009,792 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_0046247575,958,486 - 6,000,103 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247575,956,873 - 6,000,052 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Nod2
164 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:103
Count of miRNA genes:83
Interacting mature miRNAs:92
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7411590Foco7Food consumption QTL 76.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)19124688055Rat
10054132Srcrt9Stress Responsive Cort QTL 92.870.0017blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19127355345Rat
631678Cm9Cardiac mass QTL 94.270.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)19128982497Rat
631681Cm12Cardiac mass QTL 123.330.00053heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)19128982497Rat
1549847Bss8Bone structure and strength QTL 84lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)19131963836Rat
9590298Uminl5Urine mineral level QTL 53.590.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)19136824771Rat
8552935Pigfal10Plasma insulin-like growth factor 1 level QTL 105.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)19136824771Rat
9590250Scort11Serum corticosterone level QTL 1123.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19136824771Rat
9590090Insglur8Insulin/glucose ratio QTL 810.810.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)19136824771Rat
9589102Slep13Serum leptin concentration QTL 134.630.001blood leptin amount (VT:0005667)plasma leptin level (CMO:0000781)1956937445569374Rat
8694186Bw152Body weight QTL 1523.340.001body mass (VT:0001259)body weight gain (CMO:0000420)1956937445569374Rat
7247442Uae39Urinary albumin excretion QTL 39urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19218792746708701Rat
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19218792756457239Rat
61447Tcas1Tongue tumor susceptibility QTL 16.08tongue integrity trait (VT:0010553)squamous cell carcinoma of the tongue maximum tumor diameter (CMO:0001875)19231612147316121Rat
2317848Alcrsp21Alcohol response QTL 211.8999999761581420.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)19320477748204777Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19409615555283277Rat
724518Uae19Urinary albumin excretion QTL 195.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19745724942983518Rat
724565Tcas5Tongue tumor susceptibility QTL 510.04tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)19997775339654489Rat
631840Niddm38Non-insulin dependent diabetes mellitus QTL 383.86blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)191032318023069265Rat
61423Cia14Collagen induced arthritis QTL 143joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)191082797043544039Rat
61407Scl12Serum cholesterol level QTL 120.001blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)191392640130303727Rat
1558656Prcs1Prostate cancer susceptibility QTL 15prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)191511459834521833Rat
7411549Bw130Body weight QTL 13050.001body mass (VT:0001259)body weight gain (CMO:0000420)191545586057337602Rat
1331788Rf45Renal function QTL 452.818kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)191560502346559041Rat
1578764Stresp19Stress response QTL 193.60.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)191563020157337602Rat
2298478Eau8Experimental allergic uveoretinitis QTL 80.0163uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)191715443357337602Rat


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 1
Low 3 30 14 18 14 8 3 18 11
Below cutoff 27 23 23 23 8 11 66 32 21 8


RefSeq Acc Id: ENSRNOT00000065103   ⟹   ENSRNOP00000061463
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1918,382,439 - 18,417,177 (-)Ensembl
Rnor_6.0 Ensembl1919,332,594 - 19,376,789 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000080964   ⟹   ENSRNOP00000073236
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1918,382,571 - 18,417,177 (-)Ensembl
Rnor_6.0 Ensembl1919,334,619 - 19,377,492 (-)Ensembl
RefSeq Acc Id: NM_001414911   ⟹   NP_001401840
RefSeq Status: VALIDATED
Rat AssemblyChrPosition (strand)Source
GRCr81934,555,832 - 34,596,242 (-)NCBI
mRatBN7.21918,382,369 - 18,422,778 (-)NCBI
RefSeq Acc Id: XM_008772373   ⟹   XP_008770595
Rat AssemblyChrPosition (strand)Source
GRCr81934,555,906 - 34,596,281 (-)NCBI
mRatBN7.21918,395,441 - 18,422,817 (-)NCBI
Rnor_6.01919,343,174 - 19,382,301 (-)NCBI
RefSeq Acc Id: XM_039097571   ⟹   XP_038953499
Rat AssemblyChrPosition (strand)Source
GRCr81934,573,348 - 34,596,281 (-)NCBI
mRatBN7.21918,399,888 - 18,422,817 (-)NCBI
RefSeq Acc Id: XM_063277866   ⟹   XP_063133936
Rat AssemblyChrPosition (strand)Source
GRCr81934,555,906 - 34,596,281 (-)NCBI
RefSeq Acc Id: XM_063277867   ⟹   XP_063133937
Rat AssemblyChrPosition (strand)Source
GRCr81934,555,906 - 34,596,281 (-)NCBI
RefSeq Acc Id: XM_063277868   ⟹   XP_063133938
Rat AssemblyChrPosition (strand)Source
GRCr81934,555,906 - 34,596,259 (-)NCBI
RefSeq Acc Id: XP_008770595   ⟸   XM_008772373
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000061463   ⟸   ENSRNOT00000065103
RefSeq Acc Id: ENSRNOP00000073236   ⟸   ENSRNOT00000080964
RefSeq Acc Id: XP_038953499   ⟸   XM_039097571
- Peptide Label: isoform X5
- UniProtKB: A6KD97 (UniProtKB/TrEMBL),   D4A5W3 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001401840   ⟸   NM_001414911
- UniProtKB: A6KD97 (UniProtKB/TrEMBL),   D4A5W3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063133937   ⟸   XM_063277867
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063133936   ⟸   XM_063277866
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063133938   ⟸   XM_063277868
- Peptide Label: isoform X4
Protein Domains

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2K4Z7-F1-model_v2 AlphaFold A0A0G2K4Z7 1-989 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1306368 AgrOrtholog
BioCyc Gene G2FUF-6280 BioCyc
Ensembl Genes ENSRNOG00000014124 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000065103.3 UniProtKB/TrEMBL
  ENSRNOT00000080964.2 UniProtKB/TrEMBL
Gene3D-CATH 1.10.533.10 UniProtKB/TrEMBL UniProtKB/TrEMBL UniProtKB/TrEMBL
InterPro CARD UniProtKB/TrEMBL
  DEATH-like UniProtKB/TrEMBL
  Leu-rich_rpt UniProtKB/TrEMBL
  LRR_dom_sf UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
KEGG Report rno:291912 UniProtKB/TrEMBL
  LRR_6 UniProtKB/TrEMBL
PhenoGen Nod2 PhenoGen
RatGTEx ENSRNOG00000014124 RatGTEx
Superfamily-SCOP DEATH_like UniProtKB/TrEMBL
  RNI-like UniProtKB/TrEMBL
  SSF52540 UniProtKB/TrEMBL
UniProt A0A0G2K4Z7_RAT UniProtKB/TrEMBL

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2007-12-12 Nod2  nucleotide-binding oligomerization domain containing 2  Card15_predicted  caspase recruitment domain family, member 15 (predicted)  Symbol and Name updated to reflect Human and Mouse nomenclature 1299863 APPROVED
2005-01-12 Card15_predicted  caspase recruitment domain family, member 15 (predicted)      Symbol and Name status set to approved 70820 APPROVED