Herc1 (HECT and RLD domain containing E3 ubiquitin protein ligase family member 1) - Rat Genome Database

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Gene: Herc1 (HECT and RLD domain containing E3 ubiquitin protein ligase family member 1) Rattus norvegicus
Analyze
Symbol: Herc1
Name: HECT and RLD domain containing E3 ubiquitin protein ligase family member 1
RGD ID: 1306366
Description: Predicted to enable ubiquitin-protein transferase activity. Predicted to act upstream of or within several processes, including bone mineralization; bone remodeling; and nervous system development. Predicted to be located in cytoplasm. Orthologous to human HERC1 (HECT and RLD domain containing E3 ubiquitin protein ligase family member 1); PARTICIPATES IN ubiquitin/proteasome degradation pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: hect (homologous to the E6-AP (UBE3A) carboxyl terminus) domain and RCC1 (CHC1)-like domain (RLD) 1; LOC315771; probable E3 ubiquitin-protein ligase HERC1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8875,796,347 - 75,965,347 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl875,796,357 - 75,965,347 (+)EnsemblGRCr8
mRatBN7.2866,857,169 - 67,070,318 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl866,856,935 - 67,070,312 (+)EnsemblmRatBN7.2
Rnor_6.0872,029,550 - 72,198,363 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl872,029,489 - 72,198,358 (+)Ensemblrn6Rnor6.0
Rnor_5.0871,696,247 - 71,866,080 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4870,642,670 - 70,811,822 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera866,287,307 - 66,455,898 (+)NCBICelera
RGSC_v3.1870,685,007 - 70,830,421 (+)NCBI
Cytogenetic Map8q24NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
2. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
3. GOA pipeline RGD automated data pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:7891151   PMID:19182904   PMID:20041218   PMID:30140388  


Genomics

Comparative Map Data
Herc1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8875,796,347 - 75,965,347 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl875,796,357 - 75,965,347 (+)EnsemblGRCr8
mRatBN7.2866,857,169 - 67,070,318 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl866,856,935 - 67,070,312 (+)EnsemblmRatBN7.2
Rnor_6.0872,029,550 - 72,198,363 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl872,029,489 - 72,198,358 (+)Ensemblrn6Rnor6.0
Rnor_5.0871,696,247 - 71,866,080 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4870,642,670 - 70,811,822 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera866,287,307 - 66,455,898 (+)NCBICelera
RGSC_v3.1870,685,007 - 70,830,421 (+)NCBI
Cytogenetic Map8q24NCBI
HERC1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381563,608,618 - 63,833,948 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1563,608,618 - 63,833,948 (-)Ensemblhg38GRCh38
GRCh371563,900,817 - 64,126,147 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361561,687,870 - 61,913,200 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341561,687,870 - 61,913,141NCBI
Celera1540,780,251 - 41,005,485 (-)NCBICelera
Cytogenetic Map15q22.31NCBI
HuRef1540,725,245 - 40,950,861 (-)NCBIHuRef
CHM1_11564,020,042 - 64,245,382 (-)NCBICHM1_1
T2T-CHM13v2.01561,415,858 - 61,641,183 (-)NCBIT2T-CHM13v2.0
Herc1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39966,257,694 - 66,416,057 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl966,257,732 - 66,416,057 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38966,350,412 - 66,508,775 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl966,350,450 - 66,508,775 (+)Ensemblmm10GRCm38
MGSCv37966,198,257 - 66,356,582 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36966,148,456 - 66,309,055 (+)NCBIMGSCv36mm8
Celera963,584,587 - 63,742,741 (+)NCBICelera
Cytogenetic Map9CNCBI
cM Map935.86NCBI
Herc1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545011,525,246 - 11,719,992 (+)Ensembl
ChiLan1.0NW_00495545011,525,245 - 11,719,992 (+)NCBIChiLan1.0ChiLan1.0
HERC1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21652,856,563 - 53,087,506 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11557,032,688 - 57,262,796 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01542,555,131 - 42,785,228 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11560,848,030 - 61,017,273 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1560,848,493 - 61,017,244 (-)EnsemblpanPan2panpan1.1
HERC1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13028,195,296 - 28,379,343 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3028,195,673 - 28,379,444 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3028,116,109 - 28,299,721 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03028,369,387 - 28,553,435 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3028,369,389 - 28,553,406 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13028,306,763 - 28,490,386 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03028,368,982 - 28,552,605 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03028,607,198 - 28,791,048 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Herc1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640106,294,164 - 106,482,872 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647124,141,928 - 24,330,967 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647124,142,227 - 24,330,966 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HERC1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1108,205,580 - 108,403,862 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11108,206,172 - 108,404,149 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21119,362,017 - 119,560,531 (+)NCBISscrofa10.2Sscrofa10.2susScr3
HERC1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12619,713,780 - 19,930,807 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2619,713,617 - 19,930,937 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666048121,468,297 - 121,687,435 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Herc1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247818,745,780 - 8,907,701 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247818,694,044 - 8,907,701 (+)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Herc1
544 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:92
Count of miRNA genes:74
Interacting mature miRNAs:81
Transcripts:ENSRNOT00000023646
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298065Scl16Serum cholesterol level QTL 163.8blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)83975280384752803Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)849849908118871671Rat
1578769Uae31Urinary albumin excretion QTL 313.30.001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)839106363103375781Rat
1298079Activ2Activity QTL 29.50.000001voluntary movement trait (VT:0003491)rearing measurement (CMO:0001515)85076395195763951Rat
11556286Cm81Cardiac mass QTL 810.01heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)83910625884106258Rat
70161Bp62Blood pressure QTL 622.90.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)85158969999045312Rat
1578765Klgr1Kidney lesion grade QTL 13.30.0001kidney morphology trait (VT:0002135)organ lesion measurement (CMO:0000677)839106363103375781Rat
61464Niddm11Non-insulin dependent diabetes mellitus QTL 113.10.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)84447792689477926Rat
4889938Bss89Bone structure and strength QTL 893.8tibia size trait (VT:0100001)tibia cortical bone volume (CMO:0001725)85899169791341052Rat
1578755Pur5Proteinuria QTL 53.30.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)839106258103375958Rat
631210Bw3Body weight QTL35.9mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)861019838121662124Rat
2313088Bss75Bone structure and strength QTL 753.10.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)83910625891341052Rat
8662823Vetf5Vascular elastic tissue fragility QTL 51.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)863404444108404444Rat
1358896Bp262Blood pressure QTL 2622.89arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)835464071107982864Rat
731182Uae24Urinary albumin excretion QTL 246.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)84754141992541419Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)83910625884106258Rat
631842Inf1Infertility severity QTL 14.10.001seminal gland mass (VT:0010524)seminal vesicle wet weight (CMO:0001603)83154366176543661Rat
1331769Rf39Renal function QTL 393.871urine output (VT:0003620)timed urine volume (CMO:0000260)850763951107970527Rat
1359033Bp273Blood pressure QTL 273arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83910625884106258Rat
1358906Bp253Blood pressure QTL 25340.0004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)84961020494610204Rat
61358Bp39Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)84444783789447837Rat
1358907Cm40Cardiac mass QTL 401.89heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)835464071107982864Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)855428333127966348Rat
2316950Scl66Serum cholesterol level QTL 664.1blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)839106363114525825Rat
1582254Kidm31Kidney mass QTL 313kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)84924517894245178Rat
724540Uae8Urinary albumin excretion QTL 85urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)839106258103375958Rat
10402857Bp380Blood pressure QTL 3800.95arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)862848139107848139Rat
1358892Kidm26Kidney mass QTL 263.69kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)835464071107982864Rat
1582243Bw66Body weight QTL 663.40.0048body mass (VT:0001259)body weight (CMO:0000012)84924517894245178Rat
5684973Bss100Bone structure and strength QTL 1004.7tibia area (VT:1000281)tibia area measurement (CMO:0001382)85899169791341052Rat
61373Mcs4Mammary carcinoma susceptibility QTL 41.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)84447504389475043Rat
1300177Cm2Cardiac mass QTL 23.65heart mass (VT:0007028)heart weight (CMO:0000017)863141536109261840Rat
2313057Bss76Bone structure and strength QTL 7630.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)83910625891341052Rat
12879878Bw183Body weight QTL 1830.001body mass (VT:0001259)body weight (CMO:0000012)862848139107848139Rat
1549908Neudeg1Neurodegradation QTL 15.50nervous system integrity trait (VT:0010566)logarithm of the ratio of the lesioned side motor neuron count to contralateral side motor neuron count (CMO:0001986)858337123103337123Rat
12879879Cm99Cardiac mass QTL 990.001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)862848139107848139Rat
1331804Cm30Cardiac mass QTL 303.77443heart mass (VT:0007028)heart wet weight (CMO:0000069)862970527107970527Rat
2313067Bss77Bone structure and strength QTL 773.10.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)83910625891341052Rat
12879880Cm100Cardiac mass QTL 1000.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)862848139107848139Rat
12879881Cm101Cardiac mass QTL 1010.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)862848139107848139Rat
12879882Am8Aortic mass QTL 80.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)862848139107848139Rat
12879883Kidm65Kidney mass QTL 650.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)862848139107848139Rat
71120Niddm21Non-insulin dependent diabetes mellitus QTL 213.73blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)866992095111992095Rat
1358912Bw51Body weight QTL 512.95body mass (VT:0001259)body weight (CMO:0000012)860248093105248093Rat
2313086Bss60Bone structure and strength QTL 604.10.0001tibia length (VT:0004357)tibia length (CMO:0000450)85899169791341052Rat
2293697Bmd39Bone mineral density QTL 39femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)862848139107848139Rat
1331837Bw23Body weight QTL 234.190.00007body mass (VT:0001259)body weight (CMO:0000012)855428416107963099Rat
1331838Niddm61Non-insulin dependent diabetes mellitus QTL 613.530.0004blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)862963099107963099Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)870041301121080908Rat
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)868690349119799881Rat
2313046Bss78Bone structure and strength QTL 783.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)83910625891341052Rat
631664Hcar3Hepatocarcinoma resistance QTL 32.90.0005liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)862982864107982864Rat
2301402Bp316Blood pressure QTL 3160.005arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)862848139107848139Rat

Markers in Region
A002A45  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2867,070,065 - 67,070,219 (+)MAPPERmRatBN7.2
Rnor_6.0872,198,111 - 72,198,264NCBIRnor6.0
Rnor_5.0871,865,828 - 71,865,981UniSTSRnor5.0
RGSC_v3.4870,811,570 - 70,811,723UniSTSRGSC3.4
Celera866,455,646 - 66,455,799UniSTS
Cytogenetic Map8q24UniSTS
RH142779  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2866,984,419 - 66,984,659 (+)MAPPERmRatBN7.2
Rnor_6.0872,112,620 - 72,112,859NCBIRnor6.0
RGSC_v3.4870,726,332 - 70,726,571UniSTSRGSC3.4
Celera866,370,369 - 66,370,608UniSTS
RH 3.4 Map8849.4UniSTS
Cytogenetic Map8q24UniSTS
RH143164  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2866,900,501 - 66,900,690 (+)MAPPERmRatBN7.2
Rnor_6.0872,028,734 - 72,028,922NCBIRnor6.0
Rnor_5.0871,695,389 - 71,695,577UniSTSRnor5.0
RGSC_v3.4870,641,887 - 70,642,075UniSTSRGSC3.4
Celera866,286,491 - 66,286,679UniSTS
RH 3.4 Map8845.9UniSTS
Cytogenetic Map8q24UniSTS
BE102721  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2867,029,165 - 67,029,347 (+)MAPPERmRatBN7.2
Rnor_6.0872,157,212 - 72,157,393NCBIRnor6.0
Rnor_5.0871,824,928 - 71,825,109UniSTSRnor5.0
RGSC_v3.4870,770,670 - 70,770,851UniSTSRGSC3.4
Celera866,414,745 - 66,414,926UniSTS
RH 3.4 Map8848.0UniSTS
Cytogenetic Map8q24UniSTS
G19869  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2867,070,065 - 67,070,219 (+)MAPPERmRatBN7.2
Rnor_6.0872,198,111 - 72,198,264NCBIRnor6.0
Rnor_5.0871,865,828 - 71,865,981UniSTSRnor5.0
RGSC_v3.4870,811,570 - 70,811,723UniSTSRGSC3.4
Celera866,455,646 - 66,455,799UniSTS
Cytogenetic Map8q24UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
23 13 84 213 91 90 59 148 59 6 481 274 21 192 117 124 31 34 34

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001420916 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_001075834 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006226450 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006226451 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006226452 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008766397 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008766398 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008766399 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017596078 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017603670 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039082477 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063265523 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063265524 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063265525 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063265526 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063265527 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063265528 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063265529 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063265530 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063265531 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063265532 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063265533 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC110705 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226077 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ227048 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000008 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000089336   ⟹   ENSRNOP00000068838
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl875,796,357 - 75,965,347 (+)Ensembl
mRatBN7.2 Ensembl866,856,935 - 67,070,312 (+)Ensembl
Rnor_6.0 Ensembl872,029,489 - 72,198,358 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000094464   ⟹   ENSRNOP00000083024
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl866,856,935 - 67,070,312 (+)Ensembl
RefSeq Acc Id: NM_001420916   ⟹   NP_001407845
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8875,796,357 - 75,965,347 (+)NCBI
mRatBN7.2866,901,315 - 67,070,318 (+)NCBI
RefSeq Acc Id: XM_017596078   ⟹   XP_017451567
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8875,796,347 - 75,965,347 (+)NCBI
mRatBN7.2866,857,169 - 67,070,318 (+)NCBI
Rnor_6.0872,029,550 - 72,198,363 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039082477   ⟹   XP_038938405
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8875,858,749 - 75,965,347 (+)NCBI
mRatBN7.2866,963,716 - 67,070,318 (+)NCBI
RefSeq Acc Id: XM_063265523   ⟹   XP_063121593
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8875,796,347 - 75,965,347 (+)NCBI
RefSeq Acc Id: XM_063265524   ⟹   XP_063121594
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8875,796,347 - 75,965,347 (+)NCBI
RefSeq Acc Id: XM_063265525   ⟹   XP_063121595
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8875,796,347 - 75,965,347 (+)NCBI
RefSeq Acc Id: XM_063265526   ⟹   XP_063121596
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8875,796,347 - 75,965,347 (+)NCBI
RefSeq Acc Id: XM_063265527   ⟹   XP_063121597
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8875,796,347 - 75,965,347 (+)NCBI
RefSeq Acc Id: XM_063265528   ⟹   XP_063121598
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8875,796,347 - 75,965,347 (+)NCBI
RefSeq Acc Id: XM_063265529   ⟹   XP_063121599
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8875,796,347 - 75,965,347 (+)NCBI
RefSeq Acc Id: XM_063265530   ⟹   XP_063121600
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8875,796,347 - 75,965,347 (+)NCBI
RefSeq Acc Id: XM_063265531   ⟹   XP_063121601
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8875,796,347 - 75,965,347 (+)NCBI
RefSeq Acc Id: XM_063265532   ⟹   XP_063121602
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8875,796,347 - 75,965,347 (+)NCBI
RefSeq Acc Id: XM_063265533   ⟹   XP_063121603
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8875,796,347 - 75,923,066 (+)NCBI
RefSeq Acc Id: XP_017451567   ⟸   XM_017596078
- Peptide Label: isoform X8
- UniProtKB: A0A8I5ZV70 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000068838   ⟸   ENSRNOT00000089336
RefSeq Acc Id: XP_038938405   ⟸   XM_039082477
- Peptide Label: isoform X12
- UniProtKB: A6J5I1 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000083024   ⟸   ENSRNOT00000094464
RefSeq Acc Id: NP_001407845   ⟸   NM_001420916
- UniProtKB: A0A0G2JTT6 (UniProtKB/TrEMBL),   A0A8I5ZV70 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063121593   ⟸   XM_063265523
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZV70 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063121599   ⟸   XM_063265529
- Peptide Label: isoform X7
- UniProtKB: A0A8I5ZV70 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063121595   ⟸   XM_063265525
- Peptide Label: isoform X3
- UniProtKB: A0A8I5ZV70 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063121601   ⟸   XM_063265531
- Peptide Label: isoform X10
- UniProtKB: A0A8I5ZV70 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063121597   ⟸   XM_063265527
- Peptide Label: isoform X5
- UniProtKB: A0A8I5ZV70 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063121594   ⟸   XM_063265524
- Peptide Label: isoform X2
- UniProtKB: A0A8I5ZV70 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063121596   ⟸   XM_063265526
- Peptide Label: isoform X4
- UniProtKB: A0A8I5ZV70 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063121598   ⟸   XM_063265528
- Peptide Label: isoform X6
- UniProtKB: A0A8I5ZV70 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063121602   ⟸   XM_063265532
- Peptide Label: isoform X11
- UniProtKB: A0A8I5ZV70 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063121600   ⟸   XM_063265530
- Peptide Label: isoform X9
- UniProtKB: A0A8I5ZV70 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063121603   ⟸   XM_063265533
- Peptide Label: isoform X13
Protein Domains
B30.2/SPRY   HECT

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696096
Promoter ID:EPDNEW_R6611
Type:multiple initiation site
Name:Herc1_1
Description:HECT and RLD domain containing E3 ubiquitin protein ligase familymember 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0872,029,547 - 72,029,607EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1306366 AgrOrtholog
BioCyc Gene G2FUF-30022 BioCyc
Ensembl Genes ENSRNOG00000051671 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000089336 ENTREZGENE
  ENSRNOT00000089336.2 UniProtKB/TrEMBL
  ENSRNOT00000094464.1 UniProtKB/TrEMBL
Gene3D-CATH 2.130.10.10 UniProtKB/TrEMBL
  2.130.10.30 UniProtKB/TrEMBL
  2.60.120.920 UniProtKB/TrEMBL
  Hect, E3 ligase catalytic domain UniProtKB/TrEMBL
  Hect, E3 ligase catalytic domain UniProtKB/TrEMBL
  Hect, E3 ligase catalytic domains UniProtKB/TrEMBL
InterPro B30.2/SPRY UniProtKB/TrEMBL
  B30.2/SPRY_sf UniProtKB/TrEMBL
  ConA-like_dom UniProtKB/TrEMBL
  HECT UniProtKB/TrEMBL
  Hect_E3_ubiquitin_ligase UniProtKB/TrEMBL
  RCC1/BLIP-II UniProtKB/TrEMBL
  Reg_chr_condens UniProtKB/TrEMBL
  Signaling_Regulatory_Domain UniProtKB/TrEMBL
  SPRY_HERC1 UniProtKB/TrEMBL
  SPRY_rcpt UniProtKB/TrEMBL
  WD40/YVTN_repeat-like_dom UniProtKB/TrEMBL
  WD40_repeat UniProtKB/TrEMBL
  WD40_repeat_CS UniProtKB/TrEMBL
  WD40_repeat_dom_sf UniProtKB/TrEMBL
NCBI Gene 315771 ENTREZGENE
PANTHER BTK-BINDING PROTEIN-RELATED UniProtKB/TrEMBL
  HECT AND RLD DOMAIN CONTAINING E3 UBIQUITIN PROTEIN LIGASE FAMILY MEMBER 1 UniProtKB/TrEMBL
Pfam HECT UniProtKB/TrEMBL
  RCC1 UniProtKB/TrEMBL
  SPRY UniProtKB/TrEMBL
  WD40 UniProtKB/TrEMBL
  WD40_RLD UniProtKB/TrEMBL
PhenoGen Herc1 PhenoGen
PRINTS RCCNDNSATION UniProtKB/TrEMBL
PROSITE B302_SPRY UniProtKB/TrEMBL
  HECT UniProtKB/TrEMBL
  RCC1_2 UniProtKB/TrEMBL
  RCC1_3 UniProtKB/TrEMBL
  WD_REPEATS_1 UniProtKB/TrEMBL
  WD_REPEATS_2 UniProtKB/TrEMBL
  WD_REPEATS_REGION UniProtKB/TrEMBL
RatGTEx ENSRNOG00000051671 RatGTEx
SMART HECTc UniProtKB/TrEMBL
  SPRY UniProtKB/TrEMBL
  WD40 UniProtKB/TrEMBL
Superfamily-SCOP ConA_like_lec_gl UniProtKB/TrEMBL
  HECT UniProtKB/TrEMBL
  RCC1/BLIP-II UniProtKB/TrEMBL
  WD40_like UniProtKB/TrEMBL
UniProt A0A0G2JTT6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZV70 ENTREZGENE, UniProtKB/TrEMBL
  A6J5I1 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-07-17 Herc1  HECT and RLD domain containing E3 ubiquitin protein ligase family member 1  Herc1  hect (homologous to the E6-AP (UBE3A) carboxyl terminus) domain and RCC1 (CHC1)-like domain (RLD) 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Herc1  hect (homologous to the E6-AP (UBE3A) carboxyl terminus) domain and RCC1 (CHC1)-like domain (RLD) 1   Herc1_predicted  hect (homologous to the E6-AP (UBE3A) carboxyl terminus) domain and RCC1 (CHC1)-like domain (RLD) 1 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Herc1_predicted  hect (homologous to the E6-AP (UBE3A) carboxyl terminus) domain and RCC1 (CHC1)-like domain (RLD) 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED