Clca1 (chloride channel accessory 1) - Rat Genome Database

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Gene: Clca1 (chloride channel accessory 1) Rattus norvegicus
Analyze
Symbol: Clca1
Name: chloride channel accessory 1
RGD ID: 1306258
Description: Predicted to enable intracellularly calcium-gated chloride channel activity. Involved in cellular response to hypoxia. Located in zymogen granule membrane. Human ortholog(s) of this gene implicated in asthma and chronic obstructive pulmonary disease. Orthologous to human CLCA1 (chloride channel accessory 1); INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 17beta-estradiol 3-benzoate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: calcium-activated chloride channel regulator 1; chloride channel calcium activated 3; Clca3; LOC308015
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82236,599,022 - 236,624,714 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2236,599,022 - 236,624,714 (-)EnsemblGRCr8
mRatBN7.22233,938,677 - 233,964,369 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2233,938,677 - 233,964,369 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2241,727,691 - 241,753,301 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02239,617,800 - 239,643,385 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02234,485,318 - 234,510,926 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02250,897,980 - 250,923,711 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2250,897,969 - 250,923,744 (-)Ensemblrn6Rnor6.0
Rnor_5.02269,425,672 - 269,451,524 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42243,057,135 - 243,084,146 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2225,927,785 - 225,953,924 (-)NCBICelera
RGSC_v3.12243,043,871 - 243,070,886 (-)NCBI
Cytogenetic Map2q44NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dichloroethane  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2-butoxyethanol  (ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
apigenin  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
Azoxymethane  (ISO)
benzo[a]pyrene  (ISO)
Benzo[ghi]perylene  (ISO)
beta-damascenone  (ISO)
bisphenol A  (EXP)
buta-1,3-diene  (ISO)
calcium silicate  (ISO)
carbon monoxide  (ISO)
carbon nanotube  (ISO)
carnosic acid  (ISO)
ceric oxide  (ISO)
chloroprene  (ISO)
chlorpyrifos  (ISO)
chromium(6+)  (ISO)
ciguatoxin CTX1B  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
dextran sulfate  (ISO)
dibutyl phthalate  (ISO)
diethylstilbestrol  (EXP,ISO)
doxorubicin  (ISO)
Erionite  (ISO)
ferroheme b  (EXP)
folic acid  (ISO)
formaldehyde  (EXP)
furan  (EXP)
genistein  (EXP)
heme b  (EXP)
histamine  (ISO)
hydrogen peroxide  (ISO)
isoprenaline  (ISO)
maneb  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
naphthalene  (EXP)
ozone  (ISO)
paraquat  (ISO)
phenobarbital  (ISO)
pirinixic acid  (ISO)
potassium dichromate  (ISO)
progesterone  (ISO)
resveratrol  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
sulfur dioxide  (ISO)
tamoxifen  (ISO)
testosterone  (EXP)
tetrachloromethane  (ISO)
titanium dioxide  (EXP,ISO)
tremolite asbestos  (ISO)
trimellitic anhydride  (ISO)
vancomycin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Expression of HCLCA1 in cystic fibrosis lungs is associated with mucus overproduction. Hauber HP, etal., Eur Respir J. 2004 Jun;23(6):846-50.
4. CLCA1 gene polymorphisms in chronic obstructive pulmonary disease. Hegab AE, etal., J Med Genet 2004 Mar;41(3):e27.
5. Association of the hCLCA1 gene with childhood and adult asthma. Kamada F, etal., Genes Immun. 2004 Nov;5(7):540-7.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Role of gob-5 in mucus overproduction and airway hyperresponsiveness in asthma. Nakanishi A, etal., Proc Natl Acad Sci U S A. 2001 Apr 24;98(9):5175-80. Epub 2001 Apr 10.
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Comprehensive gene review and curation RGD comprehensive gene curation
11. Hypoxic/ischemic conditions induce expression of the putative pro-death gene Clca1 via activation of extrasynaptic N-methyl-D-aspartate receptors. Wahl AS, etal., Neuroscience. 2009 Jan 12;158(1):344-52. Epub 2008 Jun 14.
12. Increased expression of human calcium-activated chloride channel 1 is correlated with mucus overproduction in the airways of Chinese patients with chronic obstructive pulmonary disease. Wang K, etal., Chin Med J (Engl). 2007 Jun 20;120(12):1051-7.
13. Genome-wide profiling identifies epithelial cell genes associated with asthma and with treatment response to corticosteroids. Woodruff PG, etal., Proc Natl Acad Sci U S A. 2007 Oct 2;104(40):15858-63. Epub 2007 Sep 26.
Additional References at PubMed
PMID:12019299   PMID:19558866   PMID:23266329   PMID:26510883  


Genomics

Comparative Map Data
Clca1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82236,599,022 - 236,624,714 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2236,599,022 - 236,624,714 (-)EnsemblGRCr8
mRatBN7.22233,938,677 - 233,964,369 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2233,938,677 - 233,964,369 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2241,727,691 - 241,753,301 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02239,617,800 - 239,643,385 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02234,485,318 - 234,510,926 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02250,897,980 - 250,923,711 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2250,897,969 - 250,923,744 (-)Ensemblrn6Rnor6.0
Rnor_5.02269,425,672 - 269,451,524 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42243,057,135 - 243,084,146 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2225,927,785 - 225,953,924 (-)NCBICelera
RGSC_v3.12243,043,871 - 243,070,886 (-)NCBI
Cytogenetic Map2q44NCBI
CLCA1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38186,468,927 - 86,500,259 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl186,468,368 - 86,501,400 (+)Ensemblhg38GRCh38
GRCh37186,934,610 - 86,965,942 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36186,707,114 - 86,738,565 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34186,646,071 - 86,677,963NCBI
Celera185,178,525 - 85,209,980 (+)NCBICelera
Cytogenetic Map1p22.3NCBI
HuRef185,045,156 - 85,076,624 (+)NCBIHuRef
CHM1_1187,049,378 - 87,080,831 (+)NCBICHM1_1
T2T-CHM13v2.0186,308,943 - 86,340,288 (+)NCBIT2T-CHM13v2.0
Clca1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393144,710,298 - 144,738,537 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3144,709,578 - 144,738,537 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm383145,004,537 - 145,032,776 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3145,003,817 - 145,032,776 (-)Ensemblmm10GRCm38
MGSCv373144,667,501 - 144,695,740 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv363144,941,924 - 144,970,145 (-)NCBIMGSCv36mm8
Celera3151,445,713 - 151,476,303 (-)NCBICelera
Cytogenetic Map3H2NCBI
cM Map369.26NCBI
Clca1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554237,684,709 - 7,714,449 (-)Ensembl
ChiLan1.0NW_0049554237,684,741 - 7,714,438 (-)NCBIChiLan1.0ChiLan1.0
CLCA1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21140,459,454 - 140,491,142 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11139,614,852 - 139,646,540 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01118,999,099 - 119,030,839 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1187,852,383 - 87,884,267 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl187,852,599 - 87,884,751 (+)EnsemblpanPan2panpan1.1
CLCA1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1661,620,755 - 61,650,111 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl661,620,995 - 61,650,083 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha664,334,464 - 64,364,165 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0662,160,281 - 62,189,982 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl662,160,878 - 62,189,975 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1661,693,037 - 61,722,731 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0661,656,245 - 61,686,130 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0662,162,204 - 62,191,927 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Clca1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505896,941,723 - 96,975,427 (+)NCBIHiC_Itri_2
SpeTri2.0NW_004936865155,284 - 188,988 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CLCA1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl4129,620,874 - 129,655,385 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.14129,621,259 - 129,655,385 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24142,139,255 - 142,173,314 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CLCA1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12046,930,713 - 46,964,301 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2046,927,412 - 46,963,737 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603370,846,708 - 70,880,438 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Clca1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474211,145,413 - 11,172,369 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462474211,145,406 - 11,172,369 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Clca1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1315,816,494 - 15,842,378 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Clca1
292 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:411
Count of miRNA genes:236
Interacting mature miRNAs:278
Transcripts:ENSRNOT00000018373
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331734Bp204Blood pressure QTL 2043.61192arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2170656145239614549Rat
631501Bp101Blood pressure QTL 1012.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2205135267250135267Rat
2307174Activ3Activity QTL 34.830.000058locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)2210956252251712708Rat
1598813Memor9Memory QTL 92.7exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)2202029709236904960Rat
8693697Alc36Alcohol consumption QTL 3620.592drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)2219814164239320906Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2143344967251712708Rat
1298075Scl17Serum cholesterol level QTL 173.4blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)2214404877251712708Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2143344967251712708Rat
1300126Bp175Blood pressure QTL 1753.46arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2204795005249795005Rat
7207484Bss108Bone structure and strength QTL 1085.3femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)2214404877251712708Rat
2313073Bmd75Bone mineral density QTL 754.10.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)2218051934251712708Rat
61398Bp50Blood pressure QTL 504.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2192287802237287802Rat
7207482Bss107Bone structure and strength QTL 1077femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)2214404877251712708Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2205135267250135267Rat
1549836Bss2Bone structure and strength QTL 27.5femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)2214404877251712708Rat
2317752Glom23Glomerulus QTL 233.6urine protein amount (VT:0005160)urine protein level (CMO:0000591)2196140964251540988Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)2205135267250135267Rat
1331767Hrtrt12Heart rate QTL 123.373heart pumping trait (VT:2000009)heart rate (CMO:0000002)2221088977243501206Rat
2293833Kiddil8Kidney dilation QTL 82.9kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)2220274283249795005Rat
1598835Anxrr18Anxiety related response QTL 182.98body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)2203664411248664411Rat
7207490Bss111Bone structure and strength QTL 1116.4femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)2214404877251712708Rat
8693622Alc26Alcohol consumption QTL 262.40.667drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)2223810546243965570Rat
61366Iddm3Insulin dependent diabetes mellitus QTL 34.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2192287802237287802Rat
2293844Kiddil7Kidney dilation QTL 73.5kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)2220274283249795005Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2151869660251712708Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 4 7 58 29 39 8 12 8 6 108 29 1 51 52 81 31 1 1

Sequence


Ensembl Acc Id: ENSRNOT00000084996   ⟹   ENSRNOP00000070057
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2236,599,022 - 236,624,714 (-)Ensembl
mRatBN7.2 Ensembl2233,938,677 - 233,964,369 (-)Ensembl
Rnor_6.0 Ensembl2250,897,969 - 250,923,744 (-)Ensembl
RefSeq Acc Id: NM_001107449   ⟹   NP_001100919
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82236,599,022 - 236,624,714 (-)NCBI
mRatBN7.22233,938,677 - 233,964,369 (-)NCBI
Rnor_6.02250,897,980 - 250,923,711 (-)NCBI
Rnor_5.02269,425,672 - 269,451,524 (-)NCBI
RGSC_v3.42243,057,135 - 243,084,146 (-)RGD
Celera2225,927,785 - 225,953,924 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001100919 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL82389 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000070057
  ENSRNOP00000070057.1
RefSeq Acc Id: NP_001100919   ⟸   NM_001107449
- Peptide Label: precursor
- UniProtKB: A0A0G2JWX9 (UniProtKB/TrEMBL),   A6HWA3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000070057   ⟸   ENSRNOT00000084996
Protein Domains
VWFA

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2JWX9-F1-model_v2 AlphaFold A0A0G2JWX9 1-910 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691805
Promoter ID:EPDNEW_R2330
Type:multiple initiation site
Name:Clca1_1
Description:chloride channel accessory 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02250,923,723 - 250,923,783EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1306258 AgrOrtholog
BioCyc Gene G2FUF-50932 BioCyc
Ensembl Genes ENSRNOG00000060831 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000084996 ENTREZGENE
  ENSRNOT00000084996.3 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
  3.40.50.410 UniProtKB/TrEMBL
InterPro CaCC_prot UniProtKB/TrEMBL
  Cl_channel_Ca UniProtKB/TrEMBL
  CLCR UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  VWF_A UniProtKB/TrEMBL
  vWFA_dom_sf UniProtKB/TrEMBL
KEGG Report rno:308015 UniProtKB/TrEMBL
NCBI Gene 308015 ENTREZGENE
PANTHER CALCIUM-ACTIVATED CHLORIDE CHANNEL REGULATOR UniProtKB/TrEMBL
  CALCIUM-ACTIVATED CHLORIDE CHANNEL REGULATOR 1 UniProtKB/TrEMBL
Pfam CLCA_N UniProtKB/TrEMBL
  VWA_2 UniProtKB/TrEMBL
PhenoGen Clca1 PhenoGen
PROSITE VWFA UniProtKB/TrEMBL
RatGTEx ENSRNOG00000060831 RatGTEx
SMART VWA UniProtKB/TrEMBL
Superfamily-SCOP SSF53300 UniProtKB/TrEMBL
UniProt A0A0G2JWX9 ENTREZGENE, UniProtKB/TrEMBL
  A6HWA3 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2010-11-11 Clca1  chloride channel accessory 1  Clca3  chloride channel calcium activated 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Clca3  chloride channel calcium activated 3   Clca3_predicted  chloride channel calcium activated 3 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Clca3_predicted  chloride channel calcium activated 3 (predicted)      Symbol and Name status set to approved 70820 APPROVED