Lrp1b (LDL receptor related protein 1B) - Rat Genome Database

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Gene: Lrp1b (LDL receptor related protein 1B) Rattus norvegicus
Analyze
Symbol: Lrp1b
Name: LDL receptor related protein 1B
RGD ID: 1306160
Description: Predicted to enable low-density lipoprotein particle receptor activity. Involved in response to organic cyclic compound. Predicted to be located in membrane. Predicted to be part of receptor complex. Human ortholog(s) of this gene implicated in gastrointestinal system cancer (multiple); lung disease (multiple); and melanoma. Orthologous to human LRP1B (LDL receptor related protein 1B); INTERACTS WITH 17alpha-ethynylestradiol; 6-propyl-2-thiouracil; bisphenol A.
Type: protein-coding
RefSeq Status: MODEL
Previously known as: AABR07051892.1; LOC311926; low density lipoprotein receptor-related protein 1B; low density lipoprotein-related protein 1B (deleted in tumors); low-density lipoprotein receptor-related protein 1B; null
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2324,594,302 - 26,715,037 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl324,594,991 - 26,715,505 (-)Ensembl
Rnor_6.0325,201,194 - 27,348,126 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl325,921,427 - 26,056,818 (-)NCBIRnor6.0rn6Rnor6.0
Rnor_5.0330,416,590 - 32,551,691 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4320,761,304 - 22,918,609 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1320,657,918 - 22,334,356 (-)NCBI
Celera322,989,759 - 25,068,930 (-)NCBICelera
Cytogenetic Map3q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. C1q-induced LRP1B and GPR6 proteins expressed early in Alzheimer disease mouse models, are essential for the C1q-mediated protection against amyloid-β neurotoxicity. Benoit ME, etal., J Biol Chem. 2013 Jan 4;288(1):654-65. doi: 10.1074/jbc.M112.400168. Epub 2012 Nov 13.
2. Association of LRP1B Mutation With Tumor Mutation Burden and Outcomes in Melanoma and Non-small Cell Lung Cancer Patients Treated With Immune Check-Point Blockades. Chen H, etal., Front Immunol. 2019 May 21;10:1113. doi: 10.3389/fimmu.2019.01113. eCollection 2019.
3. Somatic mutations affect key pathways in lung adenocarcinoma. Ding L, etal., Nature. 2008 Oct 23;455(7216):1069-75. doi: 10.1038/nature07423.
4. High-risk Stage III colon cancer patients identified by a novel five-gene mutational signature are characterized by upregulation of IL-23A and gut bacterial translocation of the tumor microenvironment. Ge W, etal., Int J Cancer. 2020 Apr 1;146(7):2027-2035. doi: 10.1002/ijc.32775. Epub 2019 Nov 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Hypolipidemic effect of novel 2,5-bis(4-hydroxybenzylidenamino)-1,3,4-thiadiazole as potential peroxisome proliferation-activated receptor-α agonist in acute hyperlipidemic rat model. Hamadneh LA, etal., Mol Cell Biochem. 2019 Aug;458(1-2):39-47. doi: 10.1007/s11010-019-03528-5. Epub 2019 Mar 23.
7. Genomic determinants of triglyceride and cholesterol distribution into lipoprotein fractions in the rat. Hodulova M, etal., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014.
8. RNF213 gene mutation in circulating tumor DNA detected by targeted next-generation sequencing in the assisted discrimination of early-stage lung cancer from pulmonary nodules. Jiang N, etal., Thorac Cancer. 2021 Jan;12(2):181-193. doi: 10.1111/1759-7714.13741. Epub 2020 Nov 16.
9. Integrative clinical and molecular analysis of advanced biliary tract cancers on immune checkpoint blockade reveals potential markers of response. Li J, etal., Clin Transl Med. 2020 Aug;10(4):e118. doi: 10.1002/ctm2.118.
10. Effects of LRP1B Regulated by HSF1 on Lipid Metabolism in Hepatocellular Carcinoma. Li M, etal., J Hepatocell Carcinoma. 2020 Dec 8;7:361-376. doi: 10.2147/JHC.S279123. eCollection 2020.
11. Aberrant methylation impairs low density lipoprotein receptor-related protein 1B tumor suppressor function in gastric cancer. Lu YJ, etal., Genes Chromosomes Cancer. 2010 May;49(5):412-24. doi: 10.1002/gcc.20752.
12. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
13. GOA pipeline RGD automated data pipeline
14. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. Comprehensive genomic profile of Chinese lung cancer patients and mutation characteristics of individuals resistant to icotinib/gefitinib. Shang Y, etal., Sci Rep. 2020 Nov 20;10(1):20243. doi: 10.1038/s41598-020-76791-y.
17. LRP1B or TP53 mutations are associated with higher tumor mutational burden and worse survival in hepatocellular carcinoma. Wang L, etal., J Cancer. 2021 Jan 1;12(1):217-223. doi: 10.7150/jca.48983. eCollection 2021.
18. Down-regulation of LRP1B in colon cancer promoted the growth and migration of cancer cells. Wang Z, etal., Exp Cell Res. 2017 Aug 1;357(1):1-8. doi: 10.1016/j.yexcr.2017.04.010. Epub 2017 Apr 11.
19. Integrative analysis of genomic sequencing data reveals higher prevalence of LRP1B mutations in lung adenocarcinoma patients with COPD. Xiao D, etal., Sci Rep. 2017 May 18;7(1):2121. doi: 10.1038/s41598-017-02405-9.
20. Somatic Mutation Profiling of Intrahepatic Cholangiocarcinoma: Comparison between Primary and Metastasis Tumor Tissues. Xu SF, etal., J Oncol. 2020 Sep 17;2020:5675020. doi: 10.1155/2020/5675020. eCollection 2020.
21. Multi gene mutation signatures in colorectal cancer patients: predict for the diagnosis, pathological classification, staging and prognosis. Zhuang Y, etal., BMC Cancer. 2021 Apr 9;21(1):380. doi: 10.1186/s12885-021-08108-9.
Additional References at PubMed
PMID:21873635  


Genomics

Comparative Map Data
Lrp1b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2324,594,302 - 26,715,037 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl324,594,991 - 26,715,505 (-)Ensembl
Rnor_6.0325,201,194 - 27,348,126 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl325,921,427 - 26,056,818 (-)NCBIRnor6.0rn6Rnor6.0
Rnor_5.0330,416,590 - 32,551,691 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4320,761,304 - 22,918,609 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1320,657,918 - 22,334,356 (-)NCBI
Celera322,989,759 - 25,068,930 (-)NCBICelera
Cytogenetic Map3q12NCBI
LRP1B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382140,231,423 - 142,131,016 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl2140,231,423 - 142,131,016 (-)EnsemblGRCh38hg38GRCh38
GRCh372140,988,992 - 142,888,585 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362140,705,466 - 142,605,740 (-)NCBINCBI36hg18NCBI36
Build 342140,822,727 - 142,723,002NCBI
Celera2134,700,555 - 136,601,626 (-)NCBI
Cytogenetic Map2q22.1-q22.2NCBI
HuRef2132,979,804 - 134,880,174 (-)NCBIHuRef
CHM1_12140,994,306 - 142,894,408 (-)NCBICHM1_1
T2T-CHM13v2.02140,677,183 - 142,576,386 (-)NCBI
Lrp1b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39240,485,302 - 42,543,747 (-)NCBIGRCm39mm39
GRCm39 Ensembl240,485,258 - 42,543,636 (-)Ensembl
GRCm38240,595,290 - 42,653,598 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl240,595,246 - 42,653,624 (-)EnsemblGRCm38mm10GRCm38
MGSCv37240,452,293 - 42,509,118 (-)NCBIGRCm37mm9NCBIm37
MGSCv36240,418,782 - 42,475,607 (-)NCBImm8
Celera242,315,294 - 44,349,825 (-)NCBICelera
Cytogenetic Map2BNCBI
Lrp1b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554407,050,135 - 8,475,122 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554407,048,527 - 8,475,566 (-)NCBIChiLan1.0ChiLan1.0
LRP1B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12B144,316,387 - 146,222,214 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B144,382,759 - 146,221,243 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02B17,702,178 - 19,611,567 (+)NCBIMhudiblu_PPA_v0panPan3
LRP1B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11942,608,167 - 44,427,492 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1942,609,684 - 44,427,262 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1942,862,037 - 44,679,502 (-)NCBI
ROS_Cfam_1.01944,045,875 - 45,876,524 (-)NCBI
ROS_Cfam_1.0 Ensembl1944,045,827 - 45,876,493 (-)Ensembl
UMICH_Zoey_3.11942,706,549 - 44,535,337 (-)NCBI
UNSW_CanFamBas_1.01942,860,287 - 44,675,163 (-)NCBI
UU_Cfam_GSD_1.01944,109,034 - 46,068,924 (-)NCBI
Lrp1b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303105,453,907 - 107,220,269 (-)NCBI
SpeTri2.0NW_00493646935,000,773 - 36,160,216 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LRP1B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl159,613,238 - 11,499,530 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1159,612,805 - 11,499,969 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21510,898,196 - 11,701,298 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LRP1B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11025,611,400 - 27,511,903 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl1025,616,590 - 26,609,111 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666040172,851,084 - 173,703,822 (+)NCBIVero_WHO_p1.0
Lrp1b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473239,993,907 - 41,902,824 (-)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_00462473239,993,972 - 41,903,552 (-)NCBIHetGla_female_1.0hetGla2

Position Markers
D3Got19  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.0330,463,327 - 30,463,421NCBIRnor5.0
RGSC_v3.4320,828,838 - 20,828,959UniSTSRGSC3.4
RGSC_v3.4320,828,837 - 20,828,959RGDRGSC3.4
RGSC_v3.1320,725,210 - 20,725,331RGD
Celera323,036,558 - 23,036,679UniSTS
RH 3.4 Map3270.6RGD
RH 3.4 Map3270.6UniSTS
Cytogenetic Map3q12UniSTS
D3Mco16  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2325,013,650 - 25,013,911 (+)MAPPERmRatBN7.2
Rnor_6.0325,633,106 - 25,633,366NCBIRnor6.0
Rnor_5.0330,840,788 - 30,841,048UniSTSRnor5.0
RGSC_v3.4321,200,942 - 21,201,203RGDRGSC3.4
RGSC_v3.4321,200,943 - 21,201,203UniSTSRGSC3.4
RGSC_v3.1321,097,314 - 21,097,575RGD
Celera323,396,620 - 23,396,880UniSTS
Cytogenetic Map3q12UniSTS
BE121112  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2326,167,821 - 26,167,972 (+)MAPPERmRatBN7.2
Rnor_6.0326,802,444 - 26,802,594NCBIRnor6.0
Rnor_5.0332,004,275 - 32,004,425UniSTSRnor5.0
RGSC_v3.4322,403,392 - 22,403,542UniSTSRGSC3.4
Celera324,521,671 - 24,521,821UniSTS
RH 3.4 Map3294.3UniSTS
Cytogenetic Map3q12UniSTS
RH138233  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2326,341,658 - 26,341,846 (+)MAPPERmRatBN7.2
Rnor_6.0326,975,047 - 26,975,234NCBIRnor6.0
Rnor_5.0332,176,663 - 32,176,850UniSTSRnor5.0
RGSC_v3.4322,579,859 - 22,580,046UniSTSRGSC3.4
Celera324,695,195 - 24,695,382UniSTS
RH 3.4 Map3293.22UniSTS
Cytogenetic Map3q12UniSTS
RH138426  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2325,194,287 - 25,194,478 (+)MAPPERmRatBN7.2
mRatBN7.2X131,869,048 - 131,869,238 (+)MAPPERmRatBN7.2
Rnor_6.0X139,579,331 - 139,579,520NCBIRnor6.0
Rnor_6.0325,813,337 - 25,813,526NCBIRnor6.0
Rnor_5.0331,021,019 - 31,021,208UniSTSRnor5.0
Rnor_5.0X139,625,446 - 139,625,635UniSTSRnor5.0
RGSC_v3.4X139,192,178 - 139,192,367UniSTSRGSC3.4
RGSC_v3.4321,381,930 - 21,382,119UniSTSRGSC3.4
Celera323,577,159 - 23,577,348UniSTS
CeleraX130,783,132 - 130,783,321UniSTS
RH 3.4 Map51174.5UniSTS
Cytogenetic MapXq36UniSTS
Cytogenetic Map3q12UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70202Alc19Alcohol consumption QTL 192.5drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)3127494778Rat
631679Cm10Cardiac mass QTL 107.340.0001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3131158234Rat
631831Alc8Alcohol consumption QTL 82.7consumption behavior trait (VT:0002069)calculated ethanol drink intake rate (CMO:0001615)3133230976Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)diastolic blood pressure (CMO:0000005)3133278763Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)3133278763Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)pulse pressure (CMO:0000292)3133278763Rat
631545Bp85Blood pressure QTL 853.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3133278763Rat
4889966Bss95Bone structure and strength QTL 954.4tibia area (VT:1000281)tibia-fibula cross-sectional area (CMO:0001718)3136847613Rat
2312664Scl62Serum cholesterol level QTL 620.05blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)3138710544Rat
631568Bp92Blood pressure QTL 922.20.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3139874793Rat
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)3191609953Rat
1298526Arunc3Aerobic running capacity QTL 32.2exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)3822719433703538Rat
10401810Kidm53Kidney mass QTL 53kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3822719447233430Rat
70203Gcr2Gastric cancer resistance QTL 22.6stomach morphology trait (VT:0000470)stomach tumor susceptibility score (CMO:0002043)3865816227494778Rat
1358357Srcrtb1Stress Responsive Cort Basal QTL 16.360.002blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)3865816227494778Rat
6893355Bw101Body weight QTL 1010.40.38body mass (VT:0001259)body weight (CMO:0000012)31077870430357018Rat
6893363Bw105Body weight QTL 1052.60.0036body mass (VT:0001259)body weight (CMO:0000012)31077870430357018Rat
1558654Bw56Body weight QTL 564.50.0000171body mass (VT:0001259)body weight (CMO:0000012)31077870430357018Rat
70191BpQTLcluster4Blood pressure QTL cluster 43arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)31077870450302886Rat
70191BpQTLcluster4Blood pressure QTL cluster 43arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)31077870450302886Rat
1558647Cm46Cardiac mass QTL 465.40.0000055heart mass (VT:0007028)heart wet weight (CMO:0000069)31077882330356773Rat
1558650Cm48Cardiac mass QTL 4840.0001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)31077882330356773Rat
1558657Cm43Cardiac mass QTL 436.60.0000000293heart mass (VT:0007028)heart wet weight (CMO:0000069)31077882330356773Rat
1358905Hrtrt17Heart rate QTL 175.90.000014heart pumping trait (VT:2000009)heart rate (CMO:0000002)31086191289878372Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
2298542Neuinf11Neuroinflammation QTL 113.9nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)31500542276927699Rat
631676Cm8Cardiac mass QTL 87.030.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)31695470861954708Rat
634306Bp140Blood pressure QTL 1403.30.0013arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)31737470335528639Rat
634306Bp140Blood pressure QTL 1403.30.0013arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)31737470335528639Rat
634306Bp140Blood pressure QTL 1403.30.0013arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)31737470335528639Rat
634306Bp140Blood pressure QTL 1403.30.0013arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)31737470335528639Rat
634306Bp140Blood pressure QTL 1403.30.0013arterial blood pressure trait (VT:2000000)heart rate (CMO:0000002)31737470335528639Rat
634306Bp140Blood pressure QTL 1403.30.0013arterial blood pressure trait (VT:2000000)heart rate (CMO:0000002)31737470335528639Rat
634306Bp140Blood pressure QTL 1403.30.0013arterial blood pressure trait (VT:2000000)body weight (CMO:0000012)31737470335528639Rat
634306Bp140Blood pressure QTL 1403.30.0013arterial blood pressure trait (VT:2000000)body weight (CMO:0000012)31737470335528639Rat
2325840Bp345Blood pressure QTL 3450.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31831145428441896Rat
731172Bp151Blood pressure QTL 1510.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31831145447233430Rat
12879849Bw180Body weight QTL 1800.037body mass (VT:0001259)body weight (CMO:0000012)31831145447233430Rat
12879850Cm91Cardiac mass QTL 910.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)31831145447233430Rat
12879851Cm92Cardiac mass QTL 920.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)31831145447233430Rat
12879852Cm93Cardiac mass QTL 930.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)31831145447233430Rat
12879853Am5Aortic mass QTL 50.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)31831145447233430Rat
12879854Kidm63Kidney mass QTL 630.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)31831145447233430Rat
10450804Scl70Serum cholesterol level QTL 704.70.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)32071409065714090Rat
10450794Scl69Serum cholesterol level QTL 696.30.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)32071409065714090Rat
10450806Scl71Serum cholesterol level QTL 715.80.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)32419245527494778Rat
10450811Scl73Serum cholesterol level QTL 734.70.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)32419245527494778Rat
10450808Scl72Serum cholesterol level QTL 724.40.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)32419245527494778Rat
1298073Cm13Cardiac mass QTL 132.5heart mass (VT:0007028)heart wet weight (CMO:0000069)32501391138192233Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:21
Count of miRNA genes:19
Interacting mature miRNAs:21
Transcripts:ENSRNOT00000044209
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000044209   ⟹   ENSRNOP00000047160
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl324,594,991 - 26,715,505 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000096788   ⟹   ENSRNOP00000096806
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl324,594,991 - 26,715,505 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000103918   ⟹   ENSRNOP00000078520
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl326,714,530 - 26,714,948 (-)Ensembl
RefSeq Acc Id: XM_039106103   ⟹   XP_038962031
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2324,594,302 - 26,715,037 (-)NCBI
Protein Sequences
Protein RefSeqs XP_038962031 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM00491 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_038962031   ⟸   XM_039106103
RefSeq Acc Id: ENSRNOP00000047160   ⟸   ENSRNOT00000044209
RefSeq Acc Id: ENSRNOP00000078520   ⟸   ENSRNOT00000103918
RefSeq Acc Id: ENSRNOP00000096806   ⟸   ENSRNOT00000096788
Protein Domains
EGF-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1M443-F1-model_v2 AlphaFold F1M443 1-752 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (mRatBN7.2)
ACI/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN-Lx/CubMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BUF/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
DA/OlaHsd (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE16/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/FarMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB10/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF10A/StmMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/NRrrcMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MWF/Hsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHR/OlalpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WAG/RijCrl (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1306160 AgrOrtholog
BioCyc Gene G2FUF-49860 BioCyc
Ensembl Genes ENSRNOG00000030243 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000047160.5 UniProtKB/TrEMBL
  ENSRNOP00000078520.1 UniProtKB/TrEMBL
  ENSRNOP00000096806 ENTREZGENE
  ENSRNOP00000096806.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000044209.5 UniProtKB/TrEMBL
  ENSRNOT00000096788 ENTREZGENE
  ENSRNOT00000096788.1 UniProtKB/TrEMBL
  ENSRNOT00000103918.1 UniProtKB/TrEMBL
Gene3D-CATH 2.120.10.30 UniProtKB/TrEMBL
  4.10.400.10 UniProtKB/TrEMBL
InterPro 6-blade_b-propeller_TolB-like UniProtKB/TrEMBL
  cEGF UniProtKB/TrEMBL
  DUF5050 UniProtKB/TrEMBL
  EGF-like_Ca-bd_dom UniProtKB/TrEMBL
  EGF-like_dom UniProtKB/TrEMBL
  EGF-type_Asp/Asn_hydroxyl_site UniProtKB/TrEMBL
  EGF_Ca-bd_CS UniProtKB/TrEMBL
  Growth_fac_rcpt_cys_sf UniProtKB/TrEMBL
  LDL_receptor-like_sf UniProtKB/TrEMBL
  LDLR_class-A_CS UniProtKB/TrEMBL
  LDLR_classB_rpt UniProtKB/TrEMBL
  LDrepeatLR_classA_rpt UniProtKB/TrEMBL
NCBI Gene 311926 ENTREZGENE
Pfam cEGF UniProtKB/TrEMBL
  DUF5050 UniProtKB/TrEMBL
  EGF UniProtKB/TrEMBL
  EGF_CA UniProtKB/TrEMBL
  Ldl_recept_a UniProtKB/TrEMBL
  Ldl_recept_b UniProtKB/TrEMBL
PhenoGen Lrp1b PhenoGen
PRINTS LDLRECEPTOR UniProtKB/TrEMBL
PROSITE ASX_HYDROXYL UniProtKB/TrEMBL
  EGF_1 UniProtKB/TrEMBL
  EGF_2 UniProtKB/TrEMBL
  EGF_3 UniProtKB/TrEMBL
  EGF_CA UniProtKB/TrEMBL
  LDLRA_1 UniProtKB/TrEMBL
  LDLRA_2 UniProtKB/TrEMBL
  LDLRB UniProtKB/TrEMBL
SMART EGF UniProtKB/TrEMBL
  EGF_CA UniProtKB/TrEMBL
  LDLa UniProtKB/TrEMBL
  SM00135 UniProtKB/TrEMBL
Superfamily-SCOP SSF57184 UniProtKB/TrEMBL
  SSF57424 UniProtKB/TrEMBL
UniProt A0A8I5ZMX7_RAT UniProtKB/TrEMBL
  A0A8I6AQY2_RAT UniProtKB/TrEMBL
  F1M443_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-06-02 Lrp1b  LDL receptor related protein 1B  AABR07051892.1    Data Merged 737654 PROVISIONAL
2021-11-19 AABR07051892.1    AABR07051892.1    Data Merged 737654 PROVISIONAL
2021-11-19 AABR07051892.1    AABR07051892.1    Data Merged 737654 PROVISIONAL
2021-11-19 AABR07051892.1    AABR07051892.1    Data Merged 737654 PROVISIONAL
2021-11-19 AABR07051892.1    AABR07051892.1    Data Merged 737654 PROVISIONAL
2021-11-19 AABR07051892.1    AABR07051892.1    Data Merged 737654 PROVISIONAL
2021-11-19 AABR07051892.1    AABR07051892.1    Data Merged 737654 PROVISIONAL
2021-09-02 AABR07051892.1    Lrp1b  LDL receptor related protein 1B  Symbol and/or name change 19259462 PROVISIONAL
2021-08-09 Lrp1b  LDL receptor related protein 1B  AABR07051892.1    Symbol and/or name change 19259462 PROVISIONAL
2019-11-08 AABR07051892.1        Symbol and Name status set to provisional 45752 PROVISIONAL
2015-12-11 Lrp1b  LDL receptor related protein 1B  Lrp1b  low density lipoprotein receptor-related protein 1B  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-08-14 Lrp1b  low density lipoprotein receptor-related protein 1B  Lrp1b  low density lipoprotein-related protein 1B (deleted in tumors)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Lrp1b  low density lipoprotein-related protein 1B (deleted in tumors)   Lrp1b_predicted  low density lipoprotein-related protein 1B (deleted in tumors) (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Lrp1b_predicted  low density lipoprotein-related protein 1B (deleted in tumors) (predicted)      Symbol and Name status set to approved 70820 APPROVED