Antkmt (adenine nucleotide translocase lysine methyltransferase) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Antkmt (adenine nucleotide translocase lysine methyltransferase) Rattus norvegicus
Analyze
Symbol: Antkmt
Name: adenine nucleotide translocase lysine methyltransferase
RGD ID: 1306126
Description: Predicted to enable protein-lysine N-methyltransferase activity. Predicted to be involved in peptidyl-lysine trimethylation and regulation of mitochondrial ATP synthesis coupled proton transport. Predicted to be located in membrane. Predicted to be active in mitochondrion. Orthologous to human ANTKMT (adenine nucleotide translocase lysine methyltransferase); INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; acrylamide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: adenine nucleotide translocase lysine N-methyltransferase; Fam173a; family with sequence similarity 173, member A; hypothetical protein LOC287150; LOC287150; MGC125270; RGD1306126; similar to hypothetical protein MGC2494; uncharacterized protein LOC287150
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81015,316,797 - 15,320,950 (-)NCBIGRCr8
GRCr8 Ensembl1015,316,772 - 15,318,656 (-)EnsemblGRCr8 Ensembl
mRatBN7.21014,812,274 - 14,814,798 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1014,812,269 - 14,814,193 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1019,551,288 - 19,553,148 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01019,040,165 - 19,042,025 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01014,540,282 - 14,542,144 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01015,160,037 - 15,161,895 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1015,159,803 - 15,161,938 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01014,972,980 - 14,974,838 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41015,057,680 - 15,059,538 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1014,481,258 - 14,483,116 (-)NCBICelera
RGSC_v3.11015,057,679 - 15,059,538 (-)NCBI
Cytogenetic Map10q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
membrane  (IEA)
mitochondrion  (IBA,IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:31213526  


Genomics

Comparative Map Data
Antkmt
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81015,316,797 - 15,320,950 (-)NCBIGRCr8
GRCr8 Ensembl1015,316,772 - 15,318,656 (-)EnsemblGRCr8 Ensembl
mRatBN7.21014,812,274 - 14,814,798 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1014,812,269 - 14,814,193 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1019,551,288 - 19,553,148 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01019,040,165 - 19,042,025 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01014,540,282 - 14,542,144 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01015,160,037 - 15,161,895 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1015,159,803 - 15,161,938 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01014,972,980 - 14,974,838 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41015,057,680 - 15,059,538 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1014,481,258 - 14,483,116 (-)NCBICelera
RGSC_v3.11015,057,679 - 15,059,538 (-)NCBI
Cytogenetic Map10q12NCBI
ANTKMT
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3816721,146 - 722,590 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl16720,581 - 722,590 (+)EnsemblGRCh38hg38GRCh38
GRCh3716771,146 - 772,590 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3616711,159 - 712,591 (+)NCBINCBI36Build 36hg18NCBI36
Celera16971,323 - 972,755 (+)NCBICelera
Cytogenetic Map16p13.3NCBI
HuRef16693,043 - 694,491 (+)NCBIHuRef
CHM1_116771,112 - 772,560 (+)NCBICHM1_1
T2T-CHM13v2.016725,320 - 726,764 (+)NCBIT2T-CHM13v2.0
Antkmt
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391726,009,474 - 26,011,761 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1726,009,054 - 26,011,875 (-)EnsemblGRCm39 Ensembl
GRCm381725,790,500 - 25,792,787 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1725,790,080 - 25,792,901 (-)EnsemblGRCm38mm10GRCm38
MGSCv371725,927,451 - 25,929,229 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361725,518,106 - 25,519,884 (-)NCBIMGSCv36mm8
Celera1726,323,312 - 26,325,090 (-)NCBICelera
Cytogenetic Map17A3.3NCBI
cM Map1712.89NCBI
Antkmt
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544216,482,450 - 16,484,164 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495544216,482,450 - 16,484,164 (-)NCBIChiLan1.0ChiLan1.0
ANTKMT
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v218961,681 - 963,197 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1164,745,726 - 4,747,059 (+)NCBINHGRI_mPanPan1
PanPan1.116733,726 - 735,794 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl16733,726 - 735,794 (+)Ensemblpanpan1.1panPan2
ANTKMT
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1639,861,436 - 39,863,872 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha641,126,109 - 41,127,442 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0640,204,585 - 40,205,918 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl640,203,499 - 40,227,542 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1639,893,189 - 39,894,522 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0639,853,397 - 39,854,729 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0640,332,281 - 40,333,614 (-)NCBIUU_Cfam_GSD_1.0
ANTKMT
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl341,057,649 - 41,062,032 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1341,057,727 - 41,059,309 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2341,418,611 - 41,420,186 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ANTKMT
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.15639,508 - 642,305 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366606830,493,382 - 30,494,800 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Antkmt
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249131,529,628 - 1,531,333 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249131,528,289 - 1,531,333 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Antkmt
77 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:54
Count of miRNA genes:52
Interacting mature miRNAs:54
Transcripts:ENSRNOT00000026641
Prediction methods:Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10589381150893811Rat
631660Hcar1Hepatocarcinoma resistance QTL 13.40.0001liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)10666111835509383Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10666092373950353Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10589381150893811Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10125055464349221Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)10589381150893811Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101499153586964295Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014991535107713808Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)101465354159653541Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10687714251877142Rat
2293680Bss40Bone structure and strength QTL 405.660.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)10135730538Rat
7387235Uae41Urinary albumin excretion QTL 415.260.1874urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)10130004247Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10589381150893811Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10686461896620484Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1092219745922197Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014991535107556066Rat
2317754Glom25Glomerulus QTL 253.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)10210370847103708Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10589381150893811Rat
631828Alc5Alcohol consumption QTL 52.4consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)10117749933Rat
634327Hc4Hypercalciuria QTL 42.4urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)10138832698Rat

Markers in Region
AA998064  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81015,316,927 - 15,317,265 (+)Marker Load Pipeline
mRatBN7.21014,812,411 - 14,812,749 (+)MAPPERmRatBN7.2
Rnor_6.01015,160,167 - 15,160,504NCBIRnor6.0
Rnor_5.01014,973,110 - 14,973,447UniSTSRnor5.0
RGSC_v3.41015,057,810 - 15,058,147UniSTSRGSC3.4
Celera1014,481,388 - 14,481,725UniSTS
RH 3.4 Map10151.66UniSTS
Cytogenetic Map10q12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
9 11 49 113 91 90 59 25 59 6 218 97 11 93 45 60 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000026641   ⟹   ENSRNOP00000026641
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1015,316,798 - 15,318,656 (-)Ensembl
mRatBN7.2 Ensembl1014,812,281 - 14,814,177 (-)Ensembl
Rnor_6.0 Ensembl1015,159,803 - 15,161,938 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000115955   ⟹   ENSRNOP00000085813
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1015,316,772 - 15,318,656 (-)Ensembl
mRatBN7.2 Ensembl1014,812,269 - 14,814,193 (-)Ensembl
RefSeq Acc Id: NM_001127447   ⟹   NP_001120919
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81015,316,798 - 15,318,656 (-)NCBI
mRatBN7.21014,812,282 - 14,814,140 (-)NCBI
Rnor_6.01015,160,037 - 15,161,895 (-)NCBI
Rnor_5.01014,972,980 - 14,974,838 (-)NCBI
RGSC_v3.41015,057,680 - 15,059,538 (-)RGD
Celera1014,481,258 - 14,483,116 (-)RGD
Sequence:
RefSeq Acc Id: XM_039085364   ⟹   XP_038941292
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81015,316,797 - 15,320,950 (-)NCBI
mRatBN7.21014,812,281 - 14,814,798 (-)NCBI
RefSeq Acc Id: XM_039085365   ⟹   XP_038941293
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81015,316,797 - 15,320,950 (-)NCBI
mRatBN7.21014,812,274 - 14,814,044 (-)NCBI
RefSeq Acc Id: NP_001120919   ⟸   NM_001127447
- UniProtKB: D4A1T7 (UniProtKB/TrEMBL),   A6HD51 (UniProtKB/TrEMBL),   A6HD52 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000026641   ⟸   ENSRNOT00000026641
RefSeq Acc Id: XP_038941293   ⟸   XM_039085365
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038941292   ⟸   XM_039085364
- Peptide Label: isoform X1
- UniProtKB: A0A8I6A4W6 (UniProtKB/TrEMBL),   A6HD52 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000085813   ⟸   ENSRNOT00000115955

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A1T7-F1-model_v2 AlphaFold D4A1T7 1-222 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697058
Promoter ID:EPDNEW_R7583
Type:multiple initiation site
Name:Fam173a_1
Description:family with sequence similarity 173, member A
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01015,161,926 - 15,161,986EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1306126 AgrOrtholog
BioCyc Gene G2FUF-25759 BioCyc
Ensembl Genes ENSRNOG00000019684 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000026641 ENTREZGENE
  ENSRNOT00000026641.5 UniProtKB/TrEMBL
  ENSRNOT00000115955 ENTREZGENE
  ENSRNOT00000115955.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.150 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7113617 IMAGE-MGC_LOAD
InterPro FAM173A/B UniProtKB/TrEMBL
  SAM-dependent_MTases-like UniProtKB/TrEMBL
KEGG Report rno:287150 UniProtKB/TrEMBL
MGC_CLONE MGC:93938 IMAGE-MGC_LOAD
NCBI Gene 287150 ENTREZGENE
PANTHER ADENINE NUCLEOTIDE TRANSLOCASE LYSINE N-METHYLTRANSFERASE UniProtKB/TrEMBL
  PTHR13610 UniProtKB/TrEMBL
PhenoGen Antkmt PhenoGen
RatGTEx ENSRNOG00000019684 RatGTEx
Superfamily-SCOP SSF53335 UniProtKB/TrEMBL
UniProt A0A8I6A4W6 ENTREZGENE, UniProtKB/TrEMBL
  A6HD51 ENTREZGENE, UniProtKB/TrEMBL
  A6HD52 ENTREZGENE, UniProtKB/TrEMBL
  D4A1T7 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-08-05 Antkmt  adenine nucleotide translocase lysine methyltransferase  Fam173a  family with sequence similarity 173, member A  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-09 Fam173a  family with sequence similarity 173, member A  RGD1306126  similar to hypothetical protein MGC2494  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 RGD1306126  similar to hypothetical protein MGC2494  RGD1306126_predicted  similar to hypothetical protein MGC2494 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-20 RGD1306126_predicted  similar to hypothetical protein MGC2494 (predicted)  LOC287150_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC287150_predicted  similar to hypothetical protein MGC2494 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL