Auh (AU RNA binding methylglutaconyl-CoA hydratase) - Rat Genome Database

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Gene: Auh (AU RNA binding methylglutaconyl-CoA hydratase) Rattus norvegicus
Analyze
Symbol: Auh
Name: AU RNA binding methylglutaconyl-CoA hydratase
RGD ID: 1306087
Description: Predicted to enable enoyl-CoA hydratase activity; mRNA 3'-UTR binding activity; and methylglutaconyl-CoA hydratase activity. Predicted to be involved in fatty acid beta-oxidation. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in 3-methylglutaconic aciduria type 1 and renal tubular transport disease. Orthologous to human AUH (AU RNA binding methylglutaconyl-CoA hydratase); PARTICIPATES IN 3-hydroxy-3-methylglutaryl-CoA lyase deficiency pathway; 3-hydroxyisobutyric aciduria pathway; 3-methylcrotonyl CoA carboxylase 1 deficiency pathway; INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 3-MG-CoA hydratase; AU RNA binding protein/enoyl-CoA hydratase; AU RNA binding protein/enoyl-Coenzyme A hydratase; AU-binding enoyl-CoA hydratase; AU-specific RNA-binding enoyl-CoA hydratase; itaconyl-CoA hydratase; LOC361215; methylglutaconyl-CoA hydratase, mitochondrial
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81712,481,396 - 12,576,748 (+)NCBIGRCr8
mRatBN7.21712,329,522 - 12,424,882 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1712,329,524 - 12,424,896 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1712,264,027 - 12,359,120 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01713,861,533 - 13,956,350 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01712,178,505 - 12,273,314 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01712,310,178 - 12,405,224 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1712,310,214 - 12,405,205 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01714,407,790 - 14,501,296 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41718,147,850 - 18,251,863 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11718,141,903 - 18,251,849 (+)NCBI
Celera1712,101,042 - 12,189,320 (+)NCBICelera
Cytogenetic Map17p14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
1,1-dichloroethene  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dinitrotoluene  (EXP)
4-hydroxyphenyl retinamide  (ISO)
acetamide  (EXP)
aflatoxin B1  (ISO)
aristolochic acid A  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
butanal  (ISO)
cadmium atom  (ISO)
carbon nanotube  (ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
dicrotophos  (ISO)
diuron  (EXP)
doxorubicin  (ISO)
entacapone  (EXP)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
fipronil  (EXP)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
furan  (EXP)
genistein  (EXP)
gentamycin  (EXP)
glyphosate  (ISO)
indometacin  (EXP)
inulin  (ISO)
menadione  (ISO)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
N,N-diethyl-m-toluamide  (EXP)
nefazodone  (EXP)
ozone  (ISO)
paracetamol  (ISO)
PCB138  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
permethrin  (EXP)
phenobarbital  (ISO)
PhIP  (EXP)
phlorizin  (ISO)
pirinixic acid  (ISO)
quartz  (ISO)
quercetin  (EXP,ISO)
resveratrol  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (EXP)
Soman  (EXP)
sulindac  (EXP)
sunitinib  (ISO)
tetrachloromethane  (EXP)
tetracycline  (ISO)
thapsigargin  (ISO)
thioacetamide  (EXP)
tolcapone  (EXP)
trichloroethene  (EXP)
trimellitic anhydride  (ISO)
tunicamycin  (ISO)
vancomycin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
mitochondrion  (IBA,IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. 3-Methylglutaconic aciduria type I is caused by mutations in AUH. IJlst L, etal., Am J Hum Genet. 2002 Dec;71(6):1463-6. Epub 2002 Nov 14.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:7892223   PMID:10072761   PMID:12477932   PMID:14651853   PMID:18614015  


Genomics

Comparative Map Data
Auh
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81712,481,396 - 12,576,748 (+)NCBIGRCr8
mRatBN7.21712,329,522 - 12,424,882 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1712,329,524 - 12,424,896 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1712,264,027 - 12,359,120 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01713,861,533 - 13,956,350 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01712,178,505 - 12,273,314 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01712,310,178 - 12,405,224 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1712,310,214 - 12,405,205 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01714,407,790 - 14,501,296 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41718,147,850 - 18,251,863 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11718,141,903 - 18,251,849 (+)NCBI
Celera1712,101,042 - 12,189,320 (+)NCBICelera
Cytogenetic Map17p14NCBI
AUH
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38991,213,823 - 91,361,918 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl991,213,815 - 91,361,918 (-)EnsemblGRCh38hg38GRCh38
GRCh37993,976,105 - 94,124,200 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36993,015,926 - 93,163,996 (-)NCBINCBI36Build 36hg18NCBI36
Build 34991,055,663 - 91,203,730NCBI
Celera964,410,745 - 64,558,849 (-)NCBICelera
Cytogenetic Map9q22.31NCBI
HuRef963,656,405 - 63,804,572 (-)NCBIHuRef
CHM1_1994,122,573 - 94,270,676 (-)NCBICHM1_1
T2T-CHM13v2.09103,379,966 - 103,528,055 (-)NCBIT2T-CHM13v2.0
Auh
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391352,989,155 - 53,083,742 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1352,989,155 - 53,083,717 (-)EnsemblGRCm39 Ensembl
GRCm381352,835,107 - 52,929,704 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1352,835,119 - 52,929,681 (-)EnsemblGRCm38mm10GRCm38
MGSCv371352,930,479 - 53,025,046 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361352,847,551 - 52,942,093 (-)NCBIMGSCv36mm8
Celera1353,911,509 - 54,006,402 (-)NCBICelera
Cytogenetic Map13A5- B1NCBI
cM Map1327.68NCBI
Auh
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955515971,800 - 1,123,474 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955515971,778 - 1,124,019 (+)NCBIChiLan1.0ChiLan1.0
AUH
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21148,130,027 - 48,280,795 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1948,132,422 - 48,283,191 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0962,269,809 - 62,420,577 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1990,369,250 - 90,519,789 (-)NCBIpanpan1.1PanPan1.1panPan2
AUH
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1195,547,822 - 95,707,654 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl195,547,843 - 95,707,471 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha196,001,456 - 96,161,244 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0196,148,200 - 96,308,147 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl196,148,210 - 96,308,147 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1195,780,326 - 95,939,995 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0195,500,167 - 95,659,929 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0196,260,104 - 96,419,890 (+)NCBIUU_Cfam_GSD_1.0
Auh
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494412,840,014 - 12,999,988 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936796161,003 - 303,250 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936796160,335 - 302,458 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AUH
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl142,398,462 - 2,546,342 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1142,398,456 - 2,546,329 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2143,074,971 - 3,222,311 (-)NCBISscrofa10.2Sscrofa10.2susScr3
AUH
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.112101,654,957 - 101,799,863 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl12101,653,386 - 101,799,792 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603889,980,978 - 90,122,961 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Auh
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248681,200,800 - 1,392,461 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248681,200,862 - 1,392,844 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Auh
506 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:59
Count of miRNA genes:52
Interacting mature miRNAs:59
Transcripts:ENSRNOT00000015786
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9590316Scort21Serum corticosterone level QTL 214.750.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17122871563Rat
10401807Kidm52Kidney mass QTL 52kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)17131701463Rat
70184BpQTLcluster14Blood pressure QTL cluster 143.38arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)17131990913Rat
631207Niddm41Non-insulin dependent diabetes mellitus QTL 41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)17137830672Rat
1354658Spl8Serum phospholipid level QTL 83.8blood VLDL phospholipid amount (VT:0010507)blood very low density lipoprotein phospholipid level (CMO:0001571)17160781592Rat
1354581Bp247Blood pressure QTL 2474.5arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)17169599340Rat
1354662Rf49Renal function QTL 492.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)17169599340Rat
1641902Colcr7Colorectal carcinoma resistance QTL 73.350.0044intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)17211514921881669Rat
1300123Bp194Blood pressure QTL 1942.82arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)17211514934551001Rat
631499Stl1Serum triglyceride level QTL 13.6blood triglyceride amount (VT:0002644)blood triglyceride level (CMO:0000118)17327139827389946Rat
2324619Coatc4Coat color QTL 40.001coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)17429913021293263Rat
2324619Coatc4Coat color QTL 40.001coat/hair pigmentation trait (VT:0010463)pigmented dorsal coat/hair area to total dorsal coat/hair area ratio (CMO:0001811)17429913021293263Rat
1354613Kidm14Kidney mass QTL 146.2kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)17429913035837242Rat
1354596Bw32Body weight QTL 324.5body mass (VT:0001259)body weight (CMO:0000012)17429913060781592Rat
1354630Cm34Cardiac mass QTL 348.7heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)17429913069599340Rat
1354638Insul1Insulin level QTL 14.8blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)17429913069599340Rat
1354651Lmblg2Limb length QTL 26tibia length (VT:0004357)tibia length (CMO:0000450)17429913069599340Rat
2293648Bmd31Bone mineral density QTL 314.50.0001femur size trait (VT:1000369)femoral neck cortical cross-sectional area (CMO:0001702)17435448727028127Rat
2293664Bmd28Bone mineral density QTL 285.10.0001femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)17435448727028127Rat
2303627Vencon8Ventilatory control QTL 80.001respiration trait (VT:0001943)tidal volume (CMO:0000222)17452803849528038Rat
10054088Scort28Serum corticosterone level QTL 282.040.0102blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17452803849528038Rat
1581553Pur14Proteinuria QTL 145.30.0001urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)17797996816317111Rat
2303561Bw91Body weight QTL 912body mass (VT:0001259)body weight (CMO:0000012)17886846253868462Rat
1582199Insul5Insulin level QTL 53.40.0119blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)17920136523653323Rat
1582208Kidm32Kidney mass QTL 323.90.0018kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)17920136523653323Rat
1582224Epfw4Epididymal fat weight QTL 43.50.0058epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)17920136523653323Rat
1582225Bw67Body weight QTL 676.20.0001body mass (VT:0001259)body weight (CMO:0000012)17920136523653323Rat
1582226Bw64Body weight QTL 644.20.0017body mass (VT:0001259)body weight (CMO:0000012)17920136523653323Rat
1582241Bw70Body weight QTL 704.60.0003body mass (VT:0001259)body weight (CMO:0000012)17920136523653323Rat
1582245Bw73Body weight QTL 734.60.0004body mass (VT:0001259)body weight (CMO:0000012)17920136523653323Rat
1582258Bw76Body weight QTL 764.60.0005body mass (VT:0001259)body weight (CMO:0000012)17920136523653323Rat
2300002Iddm36Insulin dependent diabetes mellitus QTL 361.98blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)17999128640540197Rat

Markers in Region
D17Rat184  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21712,345,331 - 12,345,554 (+)MAPPERmRatBN7.2
Rnor_6.01712,325,985 - 12,326,207NCBIRnor6.0
Rnor_5.01714,423,577 - 14,423,799UniSTSRnor5.0
RGSC_v3.41718,157,669 - 18,157,892RGDRGSC3.4
RGSC_v3.41718,157,670 - 18,157,892UniSTSRGSC3.4
RGSC_v3.11718,157,669 - 18,157,892RGD
Celera1712,110,862 - 12,111,084UniSTS
SHRSP x BN Map174.23RGD
SHRSP x BN Map174.23UniSTS
Cytogenetic Map17p14UniSTS
RH128092  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21712,424,457 - 12,424,666 (+)MAPPERmRatBN7.2
Rnor_6.01712,404,786 - 12,404,994NCBIRnor6.0
Rnor_5.01714,500,858 - 14,501,066UniSTSRnor5.0
RGSC_v3.41718,251,425 - 18,251,633UniSTSRGSC3.4
Celera1712,188,882 - 12,189,090UniSTS
RH 3.4 Map1310.32UniSTS
Cytogenetic Map17p14UniSTS
RAN  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21712,347,191 - 12,348,109 (+)MAPPERmRatBN7.2
Rnor_6.01712,327,845 - 12,328,762NCBIRnor6.0
Rnor_5.01714,425,437 - 14,426,354UniSTSRnor5.0
Celera1712,112,722 - 12,113,639UniSTS
Cytogenetic Map17p14UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 34 11 8
Low 7
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000015786   ⟹   ENSRNOP00000015786
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1712,329,524 - 12,424,881 (+)Ensembl
Rnor_6.0 Ensembl1712,310,214 - 12,405,205 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000096716   ⟹   ENSRNOP00000090436
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1712,329,524 - 12,424,881 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000100823   ⟹   ENSRNOP00000083165
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1712,329,524 - 12,363,629 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000115280   ⟹   ENSRNOP00000077598
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1712,329,540 - 12,424,882 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000115684   ⟹   ENSRNOP00000077435
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1712,329,524 - 12,352,103 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000116031   ⟹   ENSRNOP00000095770
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1712,335,512 - 12,424,896 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000117360   ⟹   ENSRNOP00000095703
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1712,329,524 - 12,421,561 (+)Ensembl
RefSeq Acc Id: NM_001399250   ⟹   NP_001386179
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81712,481,421 - 12,576,748 (+)NCBI
mRatBN7.21712,329,546 - 12,424,882 (+)NCBI
RefSeq Acc Id: XM_006253675   ⟹   XP_006253737
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81712,481,400 - 12,576,748 (+)NCBI
mRatBN7.21712,329,525 - 12,424,882 (+)NCBI
Rnor_6.01712,310,178 - 12,405,210 (+)NCBI
Rnor_5.01714,407,790 - 14,501,296 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008771499   ⟹   XP_008769721
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81712,481,423 - 12,576,748 (+)NCBI
mRatBN7.21712,329,886 - 12,424,882 (+)NCBI
Rnor_6.01712,310,430 - 12,405,210 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039095856   ⟹   XP_038951784
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81712,481,397 - 12,576,748 (+)NCBI
mRatBN7.21712,329,524 - 12,424,882 (+)NCBI
RefSeq Acc Id: XR_005495293
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81712,481,399 - 12,571,093 (+)NCBI
mRatBN7.21712,329,525 - 12,419,228 (+)NCBI
RefSeq Acc Id: XR_005495294
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81712,481,396 - 12,571,093 (+)NCBI
mRatBN7.21712,329,524 - 12,419,228 (+)NCBI
RefSeq Acc Id: XP_006253737   ⟸   XM_006253675
- Peptide Label: isoform X1
- UniProtKB: A0A8I6AAT9 (UniProtKB/TrEMBL),   A0A8I5Y7Q4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008769721   ⟸   XM_008771499
- Peptide Label: isoform X2
- UniProtKB: A0A8I6B3A4 (UniProtKB/TrEMBL),   A6J6R8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000015786   ⟸   ENSRNOT00000015786
RefSeq Acc Id: XP_038951784   ⟸   XM_039095856
- Peptide Label: isoform X3
- UniProtKB: A6J6R7 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000083165   ⟸   ENSRNOT00000100823
RefSeq Acc Id: ENSRNOP00000095770   ⟸   ENSRNOT00000116031
RefSeq Acc Id: ENSRNOP00000090436   ⟸   ENSRNOT00000096716
RefSeq Acc Id: ENSRNOP00000077598   ⟸   ENSRNOT00000115280
RefSeq Acc Id: ENSRNOP00000095703   ⟸   ENSRNOT00000117360
RefSeq Acc Id: ENSRNOP00000077435   ⟸   ENSRNOT00000115684
RefSeq Acc Id: NP_001386179   ⟸   NM_001399250
- UniProtKB: F1LU71 (UniProtKB/Swiss-Prot),   A0A8I5Y7Q4 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1LU71-F1-model_v2 AlphaFold F1LU71 1-315 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700334
Promoter ID:EPDNEW_R10858
Type:multiple initiation site
Name:Auh_1
Description:AU RNA binding methylglutaconyl-CoA hydratase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01712,310,199 - 12,310,259EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1306087 AgrOrtholog
BioCyc Gene G2FUF-10109 BioCyc
BioCyc Pathway LEU-DEG2-PWY [L-leucine degradation I] BioCyc
BioCyc Pathway Image LEU-DEG2-PWY BioCyc
Ensembl Genes ENSRNOG00000011684 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055015556 UniProtKB/Swiss-Prot
  ENSRNOG00060018132 UniProtKB/Swiss-Prot
  ENSRNOG00065010094 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000015786 ENTREZGENE
  ENSRNOT00000015786.8 UniProtKB/Swiss-Prot
  ENSRNOT00000096716 ENTREZGENE
  ENSRNOT00000096716.1 UniProtKB/TrEMBL
  ENSRNOT00000100823.1 UniProtKB/TrEMBL
  ENSRNOT00000115280.1 UniProtKB/TrEMBL
  ENSRNOT00000115684.1 UniProtKB/TrEMBL
  ENSRNOT00000116031.1 UniProtKB/TrEMBL
  ENSRNOT00000117360.1 UniProtKB/TrEMBL
  ENSRNOT00055026562 UniProtKB/Swiss-Prot
  ENSRNOT00060031240 UniProtKB/Swiss-Prot
  ENSRNOT00065016269 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.12.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro ClpP/crotonase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Enoyl-CoA_hyd/isom_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Enoyl-CoA_hydra/iso UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Enoyl-CoA_hydra_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:361215 UniProtKB/TrEMBL
NCBI Gene 361215 ENTREZGENE
PANTHER ENOYL-COA HYDRATASE-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  METHYLGLUTACONYL-COA HYDRATASE, MITOCHONDRIAL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam ECH_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Auh PhenoGen
PROSITE ENOYL_COA_HYDRATASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000011684 RatGTEx
  ENSRNOG00055015556 RatGTEx
  ENSRNOG00060018132 RatGTEx
  ENSRNOG00065010094 RatGTEx
Superfamily-SCOP SSF52096 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5Y7Q4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZJH2_RAT UniProtKB/TrEMBL
  A0A8I5ZWD4_RAT UniProtKB/TrEMBL
  A0A8I6AAT9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6B3A4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GL97_RAT UniProtKB/TrEMBL
  A6J6R7 ENTREZGENE, UniProtKB/TrEMBL
  A6J6R8 ENTREZGENE, UniProtKB/TrEMBL
  AUHM_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-07-27 Auh  AU RNA binding methylglutaconyl-CoA hydratase  Auh  AU RNA binding protein/enoyl-CoA hydratase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-07-28 Auh  AU RNA binding protein/enoyl-CoA hydratase  Auh  AU RNA binding protein/enoyl-coenzyme A hydratase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Auh  AU RNA binding protein/enoyl-coenzyme A hydratase   Auh_predicted  AU RNA binding protein/enoyl-coenzyme A hydratase (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Auh_predicted  AU RNA binding protein/enoyl-coenzyme A hydratase (predicted)      Symbol and Name status set to approved 70820 APPROVED