Procr (protein C receptor) - Rat Genome Database

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Gene: Procr (protein C receptor) Rattus norvegicus
Analyze
Symbol: Procr
Name: protein C receptor
RGD ID: 1305991
Description: Predicted to enable signaling receptor activity. Predicted to be involved in negative regulation of coagulation. Located in extracellular space and perinuclear region of cytoplasm. Biomarker of acute kidney failure and carotid stenosis. Orthologous to human PROCR (protein C receptor); PARTICIPATES IN protease mediated signaling via protease-activated receptor 1; protein C anticoagulant pathway; INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 3,3',5,5'-tetrabromobisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: activated protein C receptor; APC receptor; endothelial cell protein C receptor; endothelial protein C receptor; EPCR; LOC362248; MGC114418; MGC116255; protein C receptor, endothelial
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83164,714,727 - 164,718,994 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3164,711,636 - 164,718,989 (+)EnsemblGRCr8
mRatBN7.23144,254,596 - 144,258,863 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3144,254,380 - 144,258,903 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3148,120,633 - 148,124,884 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03156,737,930 - 156,742,181 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03154,477,432 - 154,481,683 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.03151,285,321 - 151,289,581 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3151,285,249 - 151,289,595 (+)Ensemblrn6Rnor6.0
Rnor_5.03157,650,408 - 157,654,716 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.43146,268,567 - 146,273,718 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera3142,978,809 - 142,983,065 (+)NCBICelera
RGSC_v3.13146,174,188 - 146,179,297 (+)NCBI
Cytogenetic Map3q42NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-palmitoylglycerol  (ISO)
2-tert-butylhydroquinone  (ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP,ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
7,12-dimethyltetraphene  (ISO)
acetamide  (EXP)
acrolein  (ISO)
actinomycin D  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (EXP)
alpha-pinene  (ISO)
amphibole asbestos  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
Benzo[k]fluoranthene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
butyric acid  (ISO)
cadmium dichloride  (EXP,ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
choline  (ISO)
cisplatin  (ISO)
copper(II) sulfate  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
dexamethasone  (ISO)
dibenz[a,h]anthracene  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP,ISO)
diclofenac  (ISO)
dicrotophos  (ISO)
diethyl phthalate  (ISO)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dioxygen  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
etoposide  (ISO)
fluvastatin  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
furan  (EXP)
gentamycin  (EXP)
glutathione  (ISO)
hypochlorous acid  (ISO)
indometacin  (ISO)
ivermectin  (ISO)
L-methionine  (ISO)
lead diacetate  (ISO)
lipopolysaccharide  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
methotrexate  (ISO)
methoxychlor  (EXP)
methyl methacrylate  (ISO)
methyl methanesulfonate  (ISO)
Methylthiouracil  (ISO)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (EXP)
nickel atom  (ISO)
O-methyleugenol  (ISO)
okadaic acid  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
perfluorohexanesulfonic acid  (ISO)
phenylephrine  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (ISO)
propanal  (ISO)
quercetin  (ISO)
rosmarinic acid  (ISO)
rotenone  (EXP)
SB 203580  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
sodium fluoride  (ISO)
Soman  (EXP)
succimer  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
titanium dioxide  (EXP)
topotecan  (EXP)
troglitazone  (ISO)
trovafloxacin  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vorinostat  (ISO)
withaferin A  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Triggering receptor expressed on myeloid cells 1 (TREM-1) and cytokine gene variants in complicated and uncomplicated malaria. Adukpo S, etal., Trop Med Int Health. 2016 Dec;21(12):1592-1601. doi: 10.1111/tmi.12787. Epub 2016 Oct 24.
2. Mechanisms of anticoagulant and cytoprotective actions of the protein C pathway. Bouwens EA, etal., J Thromb Haemost. 2013 Jun;11 Suppl 1:242-53. doi: 10.1111/jth.12247.
3. The anticoagulant protein C pathway. Dahlback B and Villoutreix BO, FEBS Lett. 2005 Jun 13;579(15):3310-6. Epub 2005 Mar 13.
4. The protein C pathway. Esmon CT, Chest. 2003 Sep;124(3 Suppl):26S-32S.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Vascular endothelial injury and apoptosis in rats with severe acute pancreatitis. Ge N, etal., Gastroenterol Res Pract. 2015;2015:235017. doi: 10.1155/2015/235017. Epub 2015 Jan 22.
7. [Endothelial protection of tanshinone in rats of severe acute pancreatitis]. Ge N, etal., Sichuan Da Xue Xue Bao Yi Xue Ban. 2014 Mar;45(2):230-4.
8. Thrombin and protein C pathway in peripheral nerve Schwann cells. Gera O, etal., Neuroscience. 2016 Dec 17;339:587-598. doi: 10.1016/j.neuroscience.2016.10.034. Epub 2016 Oct 19.
9. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
10. Fondaparinux upregulates thrombomodulin and the endothelial protein C receptor during early-stage reperfusion in a rat model of myocardial infarction. Guillou S, etal., Thromb Res. 2016 May;141:98-103. doi: 10.1016/j.thromres.2016.02.009. Epub 2016 Feb 18.
11. Heme oxygenase 1 modulates thrombomodulin and endothelial protein C receptor levels to attenuate septic kidney injury. Kang K, etal., Shock. 2013 Aug;40(2):136-43. doi: 10.1097/SHK.0b013e31829d23f5.
12. Genome-wide microarray analyses identify the protein C receptor as a novel calcineurin/nuclear factor of activated T cells-dependent gene in vascular smooth muscle cell phenotypic modulation. Lee MY, etal., Arterioscler Thromb Vasc Biol. 2011 Nov;31(11):2665-75. doi: 10.1161/ATVBAHA.111.235960.
13. [Expression of thrombomodulin, endothelial protein C receptor in lung tissue of acute paraquat poisoned rats and intervention of sodium dimercaptopropane sulfonate]. Lu ZQ, etal., Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2009 Aug;27(8):453-6.
14. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
15. GOA pipeline RGD automated data pipeline
16. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
17. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
18. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:8449997   PMID:12477932   PMID:15489334   PMID:19581412   PMID:19680809   PMID:19696402   PMID:21423176   PMID:23376485   PMID:23533145  


Genomics

Comparative Map Data
Procr
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83164,714,727 - 164,718,994 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3164,711,636 - 164,718,989 (+)EnsemblGRCr8
mRatBN7.23144,254,596 - 144,258,863 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3144,254,380 - 144,258,903 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3148,120,633 - 148,124,884 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03156,737,930 - 156,742,181 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03154,477,432 - 154,481,683 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.03151,285,321 - 151,289,581 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3151,285,249 - 151,289,595 (+)Ensemblrn6Rnor6.0
Rnor_5.03157,650,408 - 157,654,716 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.43146,268,567 - 146,273,718 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera3142,978,809 - 142,983,065 (+)NCBICelera
RGSC_v3.13146,174,188 - 146,179,297 (+)NCBI
Cytogenetic Map3q42NCBI
PROCR
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382035,171,096 - 35,216,259 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2035,172,072 - 35,216,240 (+)Ensemblhg38GRCh38
GRCh372033,759,875 - 33,765,165 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362033,223,435 - 33,228,826 (+)NCBIBuild 36Build 36hg18NCBI36
Build 342033,223,434 - 33,228,826NCBI
Celera2030,508,610 - 30,514,000 (+)NCBICelera
Cytogenetic Map20q11.22NCBI
HuRef2030,537,700 - 30,543,125 (+)NCBIHuRef
CHM1_12033,661,021 - 33,666,433 (+)NCBICHM1_1
T2T-CHM13v2.02036,891,865 - 36,937,140 (+)NCBIT2T-CHM13v2.0
Procr
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392155,592,159 - 155,597,391 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2155,593,037 - 155,597,391 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm382155,751,125 - 155,755,478 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2155,751,117 - 155,755,471 (+)Ensemblmm10GRCm38
MGSCv372155,576,953 - 155,581,214 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv362155,442,784 - 155,446,899 (+)NCBIMGSCv36mm8
Celera2161,683,558 - 161,687,794 (+)NCBICelera
Cytogenetic Map2H1NCBI
cM Map277.26NCBI
Procr
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542226,216,002 - 26,220,101 (-)Ensembl
ChiLan1.0NW_00495542226,215,757 - 26,220,396 (-)NCBIChiLan1.0ChiLan1.0
PROCR
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22140,905,187 - 40,950,614 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12040,898,350 - 40,943,753 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02031,500,838 - 31,543,928 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12032,622,876 - 32,666,612 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2032,622,876 - 32,628,320 (+)EnsemblpanPan2panpan1.1
PROCR
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12424,184,063 - 24,188,452 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2424,184,370 - 24,187,910 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2423,830,354 - 23,833,824 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02424,857,382 - 24,880,396 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2424,875,523 - 24,879,994 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12424,163,467 - 24,166,936 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02424,258,471 - 24,261,941 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02424,697,534 - 24,701,002 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Procr
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640173,186,507 - 173,191,077 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365615,557,630 - 5,563,030 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365615,557,640 - 5,562,981 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PROCR
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1738,532,763 - 38,537,394 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11738,532,530 - 38,537,397 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21743,729,977 - 43,734,533 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PROCR
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1239,464,322 - 39,481,498 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl239,476,110 - 39,481,641 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605087,330,475 - 87,336,022 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Procr
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248424,226,900 - 4,231,264 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248424,187,635 - 4,231,277 (-)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Procr
32 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:315
Count of miRNA genes:195
Interacting mature miRNAs:234
Transcripts:ENSRNOT00000055254
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2312673Scl63Serum cholesterol level QTL 630.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)398535255168026850Rat
1578653Vnigr3Vascular neointimal growth QTL 33.1artery morphology trait (VT:0002191)artery neointimal hyperplastic lesion area (CMO:0001414)3130656562169034231Rat
1598877Bp285Blood pressure QTL 2851.50.03arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3120538241165538241Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)398535386161695835Rat
1298068Bp167Blood pressure QTL 1670.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3141074471169034231Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)347233211147415807Rat
2298477Eau4Experimental allergic uveoretinitis QTL 40.0011uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)3137398739169034231Rat
61335Bp20Blood pressure QTL 203arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3141339236155617360Rat
1581568Rf53Renal function QTL 53urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)356395968161299569Rat
1331726Bp208Blood pressure QTL 2083.129arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3141339013162184794Rat
1578754Stresp16Stress response QTL 1640.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)3112681431157681431Rat
1300173Rf11Renal function QTL 113.38renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)3121056165145956249Rat
9589106Insul23Insulin level QTL 2313.860.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)3131635904169034231Rat
10755461Coatc16Coat color QTL 16coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)3122438700167438700Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)359242096157323038Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
2303620Vencon4Ventilatory control QTL 43.9respiration trait (VT:0001943)tidal volume (CMO:0000222)3127162703168026850Rat
631841Niddm39Non-insulin dependent diabetes mellitus QTL 393.36blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)394856903159898684Rat
1576306Schws3Schwannoma susceptibility QTL 30.001nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)3118839124163839124Rat
619618Rf3Renal disease susceptibility QTL 36.50.001urine albumin amount (VT:0002871)urine albumin excretion rate to body weight ratio (CMO:0001270)3107693393152693393Rat
1300159Kidm4Kidney mass QTL 43.83kidney mass (VT:0002707)right kidney wet weight to body weight ratio (CMO:0001953)3121056165157309487Rat
5686842Rf59Renal function QTL 59urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)3140069424146976080Rat
631673Iddm13Insulin dependent diabetes mellitus QTL 131.30.663blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)3130193298161695983Rat
2312659Slep7Serum leptin concentration QTL 70.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)398535255168026850Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)341874578155617519Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)341874578155617519Rat
1581546Pur13Proteinuria QTL 132.930.0335urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)378196190146592722Rat
1578656Vnigr2Vascular neointimal growth QTL 24.2artery morphology trait (VT:0002191)lesioned artery residual lumen area (CMO:0001417)3130656562169034231Rat
8552952Pigfal13Plasma insulin-like growth factor 1 level QTL 13blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)3138799500169034231Rat
631541Bp81Blood pressure QTL 814arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3124122556169034231Rat
2312670Bw94Body weight QTL 940.01inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)398535255168026850Rat
2293087Iddm27Insulin dependent diabetes mellitus QTL 272.68blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)397551417147415807Rat

Markers in Region
AI072354  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23144,258,545 - 144,258,758 (+)MAPPERmRatBN7.2
Rnor_6.03151,289,260 - 151,289,476NCBIRnor6.0
Rnor_5.03157,654,395 - 157,654,611UniSTSRnor5.0
Celera3142,982,748 - 142,982,960UniSTS
RH 3.4 Map31303.7UniSTS
Cytogenetic Map3q42UniSTS
BF401256  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23144,255,469 - 144,255,586 (+)MAPPERmRatBN7.2
Rnor_6.03151,286,184 - 151,286,300NCBIRnor6.0
Rnor_5.03157,651,319 - 157,651,435UniSTSRnor5.0
RGSC_v3.43146,269,456 - 146,269,572UniSTSRGSC3.4
Celera3142,979,672 - 142,979,788UniSTS
RH 3.4 Map31306.0UniSTS
Cytogenetic Map3q42UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 160 91 90 59 82 59 6 344 182 11 139 79 92 31 12 12

Sequence


Ensembl Acc Id: ENSRNOT00000055254   ⟹   ENSRNOP00000052129
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3164,711,636 - 164,718,989 (+)Ensembl
mRatBN7.2 Ensembl3144,254,380 - 144,258,903 (+)Ensembl
Rnor_6.0 Ensembl3151,285,249 - 151,289,595 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000114811   ⟹   ENSRNOP00000076848
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3164,716,610 - 164,718,989 (+)Ensembl
mRatBN7.2 Ensembl3144,256,479 - 144,258,903 (+)Ensembl
RefSeq Acc Id: NM_001025733   ⟹   NP_001020904
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83164,714,727 - 164,718,994 (+)NCBI
mRatBN7.23144,254,596 - 144,258,863 (+)NCBI
Rnor_6.03151,285,321 - 151,289,581 (+)NCBI
Rnor_5.03157,650,408 - 157,654,716 (+)NCBI
RGSC_v3.43146,268,567 - 146,273,718 (+)RGD
Celera3142,978,809 - 142,983,065 (+)RGD
Sequence:
RefSeq Acc Id: NP_001020904   ⟸   NM_001025733
- Peptide Label: precursor
- UniProtKB: Q4V8I1 (UniProtKB/Swiss-Prot),   A6KI56 (UniProtKB/TrEMBL),   A0A8I5YBY0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000052129   ⟸   ENSRNOT00000055254
Ensembl Acc Id: ENSRNOP00000076848   ⟸   ENSRNOT00000114811
Protein Domains
MHC class I-like antigen recognition-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q4V8I1-F1-model_v2 AlphaFold Q4V8I1 1-241 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692588
Promoter ID:EPDNEW_R3113
Type:multiple initiation site
Name:Procr_1
Description:protein C receptor
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03151,285,312 - 151,285,372EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1305991 AgrOrtholog
BioCyc Gene G2FUF-47120 BioCyc
Ensembl Genes ENSRNOG00000019330 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000055254 ENTREZGENE
  ENSRNOT00000055254.5 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.500.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7445753 IMAGE-MGC_LOAD
  IMAGE:7462042 IMAGE-MGC_LOAD
InterPro Endothetial_C_recpt UniProtKB/Swiss-Prot
  MHC_I-like_Ag-recog UniProtKB/Swiss-Prot
  MHC_I-like_Ag-recog_sf UniProtKB/Swiss-Prot
  MHC_I/II-like_Ag-recog UniProtKB/Swiss-Prot
KEGG Report rno:362248 UniProtKB/Swiss-Prot
MGC_CLONE MGC:114418 IMAGE-MGC_LOAD
  MGC:116255 IMAGE-MGC_LOAD
NCBI Gene 362248 ENTREZGENE
PANTHER ENDOTHELIAL PROTEIN C RECEPTOR UniProtKB/Swiss-Prot
  PTHR15349 UniProtKB/Swiss-Prot
Pfam MHC_I_3 UniProtKB/Swiss-Prot
PhenoGen Procr PhenoGen
RatGTEx ENSRNOG00000019330 RatGTEx
Superfamily-SCOP SSF54452 UniProtKB/Swiss-Prot
UniProt A0A8I5YBY0 ENTREZGENE, UniProtKB/TrEMBL
  A6KI56 ENTREZGENE, UniProtKB/TrEMBL
  A6KI58_RAT UniProtKB/TrEMBL
  EPCR_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-23 Procr  protein C receptor  Procr  protein C receptor, endothelial  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Procr  protein C receptor, endothelial  Procr_predicted  protein C receptor, endothelial (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Procr_predicted  protein C receptor, endothelial (predicted)      Symbol and Name status set to approved 70820 APPROVED