Sirt7 (sirtuin 7) - Rat Genome Database

Name: Sirt7
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: Sirt7 (sirtuin 7) Rattus norvegicus

Analyze

Symbol:

Sirt7

Name:

sirtuin 7

RGD ID:

1305876

Description:

Predicted to enable several functions, including chromatin binding activity; hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides; and protein-propionyllysine depropionylase activity. Predicted to be involved in several processes, including chromatin remodeling; protein deacylation; and regulation of nucleobase-containing compound metabolic process. Predicted to be located in nuclear speck; nucleolus organizer region; and site of double-strand break. Predicted to be part of chromatin. Predicted to be active in nucleus. Orthologous to human SIRT7 (sirtuin 7); PARTICIPATES IN histone modification pathway; RNA polymerase I transcription pathway; Sirtuin mediated pathway; INTERACTS WITH (-)-epigallocatechin 3-gallate; 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

LOC303745; NAD-dependent deacetylase sirtuin-7; NAD-dependent protein deacetylase sirtuin-7; NAD-dependent protein deacylase sirtuin-7; regulatory protein SIR2 homolog 7; SIR2-like protein 7; sirtuin 7 (silent mating type information regulation 2, homolog) 7 (S. cerevisiae)

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	SIRT7 (sirtuin 7)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Sirt7 (sirtuin 7)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Sirt7 (sirtuin 7)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	SIRT7 (sirtuin 7)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	SIRT7 (sirtuin 7)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Sirt7 (sirtuin 7)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	SIRT7 (sirtuin 7)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	SIRT7 (sirtuin 7)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Sirt7 (sirtuin 7)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	SIM2 (SIM bHLH transcription factor 2)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	SIRT7 (sirtuin 7)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Sirt7 (sirtuin 7)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	sirt7 (sirtuin 7)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Sirt7	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	sirt7	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	10	105,896,476 - 105,903,301 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	105,896,476 - 105,903,172 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	10	111,000,317 - 111,006,939 (-)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	10	110,463,345 - 110,469,976 (-)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	10	105,816,930 - 105,823,624 (-)	NCBI	Rnor_WKY
Rnor_6.0	10	109,796,046 - 109,802,821 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	109,796,020 - 109,802,739 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	10	109,389,098 - 109,395,852 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	10	110,009,669 - 110,016,346 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	10	110,024,660 - 110,030,830 (-)	NCBI
Celera	10	104,439,874 - 104,446,570 (-)	NCBI		Celera
Cytogenetic Map	10	q32.3	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

fatty liver disease (ISO)

genetic disease (ISO)

Reperfusion Injury (ISO)

systemic scleroderma (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-epigallocatechin 3-gallate (EXP)

1,2-dimethylhydrazine (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

acrolein (ISO)

acrylamide (ISO)

aldehydo-D-glucose (ISO)

alpha-pinene (ISO)

aristolochic acid A (ISO)

atrazine (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

Butylbenzyl phthalate (ISO)

cadmium atom (EXP)

cerium trichloride (ISO)

CGP 52608 (ISO)

chlordecone (ISO)

cisplatin (ISO)

clofibrate (ISO)

cobalt dichloride (ISO)

copper(II) chloride (ISO)

copper(II) sulfate (ISO)

curcumin (ISO)

cyclosporin A (ISO)

D-glucose (ISO)

dioxygen (ISO)

folic acid (ISO)

glucose (ISO)

Licochalcone B (ISO)

metformin (ISO)

methamphetamine (ISO)

mono(2-ethylhexyl) phthalate (ISO)

ozone (ISO)

paclitaxel (ISO)

paracetamol (EXP,ISO)

perfluorooctanoic acid (ISO)

pirinixic acid (ISO)

propiconazole (ISO)

quercetin (ISO)

sunitinib (ISO)

tamoxifen (ISO)

tetrachloromethane (ISO)

thapsigargin (ISO)

thioacetamide (EXP)

triptonide (ISO)

tunicamycin (ISO)

valproic acid (ISO)

very-low-density lipoprotein triglyceride (ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

biological_process (ND)

DNA damage response (ISO)

DNA repair (IEA)

DNA repair-dependent chromatin remodeling (ISO,ISS)

histone H3 deacetylation (IBA)

homologous chromosome pairing at meiosis (ISO,ISS)

negative regulation of gene expression, epigenetic (ISO)

negative regulation of protein ubiquitination (ISO,ISS)

negative regulation of transcription by RNA polymerase II (ISO,ISS)

osteoblast differentiation (ISO,ISS)

positive regulation of gluconeogenesis (ISO,ISS)

positive regulation of rRNA processing (ISO,ISS)

positive regulation of transcription by RNA polymerase I (ISO,ISS)

positive regulation of transcription involved in exit from mitosis (ISO)

protein deacetylation (ISO,ISS)

protein deglutarylation (ISO,ISS)

protein depropionylation (ISO,ISS)

R-loop processing (ISO,ISS)

regulation of DNA repair (ISO)

regulation of mitochondrion organization (ISO,ISS)

regulation of protein export from nucleus (ISO,ISS)

regulation of transcription by RNA polymerase II (ISO,ISS)

regulation of transcription of nucleolar large rRNA by RNA polymerase I (ISO,ISS)

retrotransposon silencing (ISO,ISS)

rRNA transcription (ISO)

transcription initiation-coupled chromatin remodeling (ISO)

Cellular Component

chromatin (ISO,ISS)

cytoplasm (IEA)

nuclear speck (IEA,ISO)

nucleolus (ISO)

nucleolus organizer region (ISO)

nucleoplasm (ISO)

nucleus (ISO)

site of double-strand break (ISO,ISS)

Molecular Function

chromatin binding (ISO,ISS)

metal ion binding (IEA)

NAD+ binding (IEA)

NAD-dependent histone H3K18 deacetylase activity (IBA,ISO,ISS)

NAD-dependent protein deacetylase activity (ISO,ISS)

protein binding (ISO)

protein methyltransferase activity (ISO)

protein-glutaryllysine deglutarylase activity (ISO,ISS)

protein-propionyllysine depropionylase activity (ISO,ISS)

protein-succinyllysine desuccinylase activity (ISO,ISS)

transferase activity (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

histone modification pathway (ISO)

RNA polymerase I transcription pathway (ISO)

Sirtuin mediated pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	The nucleolus-guardian of cellular homeostasis and genome integrity.	Grummt I Chromosoma. 2013 Dec;122(6):487-97.
3.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
4.	Physical and functional HAT/HDAC interplay regulates protein acetylation balance.	Peserico A and Simone C, J Biomed Biotechnol. 2011;2011:371832. doi: 10.1155/2011/371832. Epub 2010 Dec 5.
5.	GOA pipeline	RGD automated data pipeline
6.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
7.	Comprehensive gene review and curation	RGD comprehensive gene curation
8.	NAD(+) in aging, metabolism, and neurodegeneration.	Verdin E Science. 2015 Dec 4;350(6265):1208-13. doi: 10.1126/science.aac4854.

Additional References at PubMed

PMID:12477932	PMID:16079181	PMID:19174463	PMID:22722849	PMID:24207024	PMID:24535021	PMID:25200183	PMID:26595207	PMID:26867678	PMID:26907567	PMID:27225932	PMID:27436229
PMID:27581932	PMID:28426094	PMID:28582407	PMID:28655758	PMID:28772218	PMID:28790157	PMID:28880264	PMID:28886238	PMID:30026585	PMID:30420520	PMID:30540930	PMID:30653310
PMID:30944854	PMID:31075303	PMID:31226208	PMID:31256246	PMID:31542297	PMID:31858380	PMID:33558457	PMID:34477918	PMID:35941302

Genomics

Comparative Map Data

Sirt7
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	10	105,896,476 - 105,903,301 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	105,896,476 - 105,903,172 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	10	111,000,317 - 111,006,939 (-)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	10	110,463,345 - 110,469,976 (-)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	10	105,816,930 - 105,823,624 (-)	NCBI	Rnor_WKY
Rnor_6.0	10	109,796,046 - 109,802,821 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	109,796,020 - 109,802,739 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	10	109,389,098 - 109,395,852 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	10	110,009,669 - 110,016,346 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	10	110,024,660 - 110,030,830 (-)	NCBI
Celera	10	104,439,874 - 104,446,570 (-)	NCBI		Celera
Cytogenetic Map	10	q32.3	NCBI

SIRT7
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	17	81,911,939 - 81,918,176 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	17	81,911,939 - 81,921,323 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	17	79,869,815 - 79,876,052 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	17	77,463,107 - 77,469,332 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	17	76,473,883 - 76,480,126 (-)	NCBI		Celera
Cytogenetic Map	17	q25.3	NCBI
HuRef	17	75,271,436 - 75,277,679 (-)	NCBI		HuRef
CHM1_1	17	79,956,019 - 79,962,262 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	17	82,779,099 - 82,785,336 (-)	NCBI		T2T-CHM13v2.0

Sirt7
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	11	120,509,197 - 120,515,840 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	11	120,509,198 - 120,516,066 (-)	Ensembl		GRCm39 Ensembl
GRCm38	11	120,618,371 - 120,625,014 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	11	120,618,372 - 120,625,240 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	11	120,479,686 - 120,486,316 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	11	120,434,461 - 120,441,057 (-)	NCBI		MGSCv36	mm8
Celera	11	132,353,665 - 132,360,296 (-)	NCBI		Celera
Cytogenetic Map	11	E2	NCBI

Sirt7
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955506	1,252,274 - 1,258,728 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955506	1,252,271 - 1,258,728 (+)	NCBI	ChiLan1.0	ChiLan1.0

SIRT7
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	17	103,348,854 - 103,355,095 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	17	76,317,560 - 76,323,761 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	17	82,020,077 - 82,026,016 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	17	82,020,077 - 82,026,289 (-)	Ensembl	panpan1.1		panPan2

SIRT7
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	9	377,141 - 383,355 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	9	376,445 - 442,919 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	9	979,255 - 985,455 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	9	970,474 - 976,673 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	9	969,764 - 976,672 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	9	995,625 - 1,001,822 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	9	1,122,234 - 1,128,418 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	9	1,200,924 - 1,207,098 (+)	NCBI		UU_Cfam_GSD_1.0

Sirt7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405602	987,406 - 993,628 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936594	5,418,796 - 5,424,988 (-)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936594	5,418,331 - 5,425,050 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SIRT7
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	12	1,078,166 - 1,084,119 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	12	1,078,155 - 1,084,112 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

SIRT7
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	16	73,785,223 - 73,792,773 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	16	73,785,695 - 73,791,947 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666077	45,237,380 - 45,244,127 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Sirt7
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624801	10,753,333 - 10,764,122 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624801	10,753,480 - 10,760,601 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Sirt7
19 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	68
Count of miRNA genes:	63
Interacting mature miRNAs:	66
Transcripts:	ENSRNOT00000054951
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2316949	Gluco60	Glucose level QTL 60	3.7		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	10	14487011	107057807	Rat
1331791	Cm31	Cardiac mass QTL 31	3.84606		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	10	29299504	107211142	Rat
61387	Bp1	Blood pressure QTL 1	5.1		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	51770177	107211142	Rat
61387	Bp1	Blood pressure QTL 1	5.1		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	10	51770177	107211142	Rat
70171	Cari1	Carrageenan-induced inflammation QTL 1	4.9	0.0005	hypodermis integrity trait (VT:0010550)	inflammatory exudate volume (CMO:0001429)	10	53797385	107211142	Rat
2313103	Bss80	Bone structure and strength QTL 80	2	0.0001	tibia strength trait (VT:1000284)	tibia midshaft endosteal cross-sectional area (CMO:0001716)	10	62057807	107057807	Rat
2313105	Bss79	Bone structure and strength QTL 79	1.8	0.0001	tibia size trait (VT:0100001)	tibia midshaft cross-sectional area (CMO:0001717)	10	62057807	107057807	Rat
61449	Ciaa2	CIA Autoantibody QTL 2	7.1		blood autoantibody amount (VT:0003725)	calculated serum anti-type 2 collagen antibody titer (CMO:0001279)	10	63221094	107211142	Rat
2317029	Aia19	Adjuvant induced arthritis QTL 19	2.98		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	10	66978955	107211142	Rat
2317039	Aia6	Adjuvant induced arthritis QTL 6	4.31		joint integrity trait (VT:0010548)	right rear ankle joint diameter (CMO:0002150)	10	66978955	107211142	Rat
10450498	Bp384	Blood pressure QTL 384		0.002	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	67750049	107211142	Rat
1642980	Bp300	Blood pressure QTL 300			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	68383129	107211142	Rat
61396	Bp9	Blood pressure QTL 9	4.8	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	68420376	107211142	Rat
2300172	Bmd57	Bone mineral density QTL 57	9.8	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	10	69738412	107211142	Rat
2293646	Bss25	Bone structure and strength QTL 25	10.96	0.0001	femur morphology trait (VT:0000559)	femur cross-sectional area (CMO:0001661)	10	69738412	107211142	Rat
2293663	Bss33	Bone structure and strength QTL 33	9.34	0.0001	femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	10	69738412	107211142	Rat
6893366	Bw106	Body weight QTL 106	0.3	0.47	body mass (VT:0001259)	body weight (CMO:0000012)	10	70199100	107211142	Rat
70193	Mcs7	Mammary carcinoma susceptibility QTL 7	2.38		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	10	72224939	107211142	Rat
2298548	Neuinf7	Neuroinflammation QTL 7	3.4		nervous system integrity trait (VT:0010566)	spinal cord RT1-B protein level (CMO:0002132)	10	72224939	107211142	Rat
2292438	Bp311	Blood pressure QTL 311			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	76246085	107211142	Rat
1302404	Cia27	Collagen induced arthritis QTL 27	2.6	0.0045	joint integrity trait (VT:0010548)	experimental arthritis severity measurement (CMO:0001459)	10	76452683	107211142	Rat
4889492	Pancm2	Pancreatic morphology QTL 2	3.2		pancreatic beta cell morphology trait (VT:0005217)	ratio of insulin-positive cell area to total area of splenic region of pancreas (CMO:0001814)	10	76748906	107211142	Rat
2303589	Bw87	Body weight QTL 87	2		body mass (VT:0001259)	body weight (CMO:0000012)	10	81285008	107211142	Rat
2317754	Glom25	Glomerulus QTL 25	3.5		urine protein amount (VT:0005160)	urine protein level (CMO:0000591)	10	82685200	107211142	Rat
631538	Oia5	Oil induced arthritis QTL 5			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	87055121	107211142	Rat
61363	Oia3	Oil induced arthritis QTL 3		0.001	joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	87307617	107211142	Rat
634320	Niddm49	Non-insulin dependent diabetes mellitus QTL 49	4.41		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	10	88539139	107211142	Rat
12880395	Cm109	Cardiac mass QTL 109		0.001	heart right ventricle mass (VT:0007033)	heart right ventricle weight to body weight ratio (CMO:0000914)	10	90404397	107211142	Rat
12880396	Am13	Aortic mass QTL 13		0.001	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	10	90404397	107211142	Rat
12880398	Kidm67	Kidney mass QTL 67		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	10	90404397	107211142	Rat
12880384	Cm107	Cardiac mass QTL 107		0.001	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)		90404397	107211142	Rat
12880385	Cm108	Cardiac mass QTL 108		0.001	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)		90404397	107211142	Rat
1579915	Bp280	Blood pressure QTL 280		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	90404397	107211142	Rat
1300137	Bp186	Blood pressure QTL 186	3.57		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	10	90627439	107057807	Rat
724530	Bp149	Blood pressure QTL 149		0.0001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	90627439	107211142	Rat
1558652	Bw57	Body weight QTL 57	4.2	0.0008	body mass (VT:0001259)	body weight (CMO:0000012)	10	90910316	107211142	Rat
1354641	Bvd2	Brain ventricular dilatation QTL 2	6.36	0.001	brain ventricle morphology trait (VT:0000822)	hydrocephalus severity score (CMO:0001881)	10	93223816	107057807	Rat
10450493	Bp382	Blood pressure QTL 382		0.002	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	94759759	107211142	Rat
2292436	Bp310	Blood pressure QTL 310			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	94759759	107211142	Rat
1578663	Bss18	Bone structure and strength QTL 18	3.6		femur width (VT:1000666)	femoral neck width (CMO:0001695)	10	96703043	107057807	Rat
1578672	Bmd16	Bone mineral density QTL 16	6.2		femur mineral mass (VT:0010011)	compact volumetric bone mineral density (CMO:0001730)	10	96703043	107057807	Rat

Markers in Region

RH130955

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	10	105,896,533 - 105,896,745 (+)	MAPPER	mRatBN7.2
Rnor_6.0	10	109,796,104 - 109,796,315	NCBI	Rnor6.0
Rnor_5.0	10	109,389,156 - 109,389,367	UniSTS	Rnor5.0
RGSC_v3.4	10	110,009,727 - 110,009,938	UniSTS	RGSC3.4
Celera	10	104,439,932 - 104,440,143	UniSTS
Cytogenetic Map	10	q32.3	UniSTS

RH138691

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	10	105,901,884 - 105,902,004 (+)	MAPPER	mRatBN7.2
Rnor_6.0	10	109,801,455 - 109,801,574	NCBI	Rnor6.0
Rnor_5.0	10	109,394,507 - 109,394,626	UniSTS	Rnor5.0
RGSC_v3.4	10	110,015,059 - 110,015,178	UniSTS	RGSC3.4
Celera	10	104,445,283 - 104,445,402	UniSTS
Cytogenetic Map	10	q32.3	UniSTS

G73110

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	10	105,898,276 - 105,898,878 (+)	MAPPER	mRatBN7.2
Rnor_6.0	10	109,797,847 - 109,798,448	NCBI	Rnor6.0
Rnor_5.0	10	109,390,899 - 109,391,500	UniSTS	Rnor5.0
RGSC_v3.4	10	110,011,470 - 110,012,071	UniSTS	RGSC3.4
Celera	10	104,441,675 - 104,442,276	UniSTS
Cytogenetic Map	10	q32.3	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	10	46	31	19	31			66	35	40	11
Low		33	11	10		10	8	11	8		1		8
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001107073	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006247889	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008768477	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039086225	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_005489874	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC131537	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC167031	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473948	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000220	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000054951 ⟹ ENSRNOP00000051834

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	10	105,896,476 - 105,903,172 (-)	Ensembl
Rnor_6.0 Ensembl	10	109,796,020 - 109,802,739 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000108043 ⟹ ENSRNOP00000086879

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	10	105,896,476 - 105,903,172 (-)	Ensembl

RefSeq Acc Id:

NM_001107073 ⟹ NP_001100543

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	10	105,896,476 - 105,903,172 (-)	NCBI
Rnor_6.0	10	109,796,046 - 109,802,742 (-)	NCBI
Rnor_5.0	10	109,389,098 - 109,395,852 (-)	NCBI
RGSC_v3.4	10	110,009,669 - 110,016,346 (-)	RGD
Celera	10	104,439,874 - 104,446,570 (-)	RGD

Sequence:

show sequence

GAAGCGCAGTCCAGGGAGCGATGGCAGCCGGTGGCGGTCTGAGCCGCTCGGAGCGCAAAGCGGC
TGAGCGGGTCCGGAGGTTGCGGGAGGAGCAGCAGCGGGAGCGCCTCCGTCAGGTGTCACGCATC
CTGAGGAAGGCGGCTGCAGAGCGCAGCGCGGAGGAGGGCCGGCTTCTAGCTGAGAGTGAGGATC
TGGTGACCGAGCTTCAGGGTCGGAGCCGGCGGCGTGAGGGCCTCAAGCGCCGCCAGGAGGAGGT
GTGTGATGACCCAGAGGAGTTGCGGAGGAAGGTCCGCGAACTAGCCGGAGCTGTCCGAAGTGCC
AGACACTTGGTTGTCTACACAGGCGCTGGGATCAGCACGGCAGCCTCTATCCCAGATTACCGGG
GTCCTAATGGAGTGTGGACACTGCTCCAGAAAGGAAGGCCTGTGAGTGCTGCCGACCTAAGCGA
AGCAGAGCCTACCCTCACCCACATGAGCATCACCCAGCTGCACAAGCATAAGCTGGTGCAACAC
GTGGTGTCTCAGAACTGCGACGGGCTCCACCTGCGCAGTGGGCTGCCACGGACCGCCATCTCTG
AGCTCCATGGGAATATGTATATTGAAGTCTGCACCTCCTGCATCCCTAACAGAGAGTACGTCCG
AGTGTTTGACGTGACGGAGCGTACCGCCCTTCACCGACACCTGACAGGCCGGACGTGCCACAAG
TGTGGGACTCAGCTTCGGGACACCATTGTGCACTTTGGGGAGAGGGGGACGCTAGGGCAGCCCC
TGAACTGGGAGGCAGCGACTGAGGCCGCTAGCAAAGCAGACACAATCCTGTGTTTAGGGTCCAG
CTTGAAGGTACTGAAGAAGTACCCCCGTCTCTGGTGCATGACGAAGCCCCCAAGCCGTCGGCCC
AAACTCTACATTGTGAACCTGCAGTGGACCCCGAAGGATGACTGGGCTGCCCTGAAGCTTCATG
GGAAATGTGATGATGTAATGCGGCTCCTCATGGACGAACTGGGCCTGGAGATCCCTGTCTACAA
CCGGTGGCAGGACCCAATCTTCTCCTTGGCAACTCCACTCCGTGCTGGCGAAGAAGGTAGCCAC
AGTAGGAAGTCACTGTGCAGGAGCAGAGAAGAGCCCCCACCCGGGGACCAGAGTGCCCCTCTTG
CCTCAGCCACCCCCATCCTAGGAGGCTGGTTCGGCAGGGGCTGTGCTAAGCGTGCAAAAAGGAA
GAAAGCGGCGTAGCCCCGGTGTTGACAAAGAGCAGTCGGCACCTTGCAGATGGCTTGACCCATG
TTTAGGGTCCTGTGTCACAGTGAAGGCTAGAGTGCCCCCACCAGATCTAGTGGAAAGAACTCTG
GGGTTGGGGGTGACACTTCCTGGTGACGGTCGTTTTTAGCCATCTGTCCTTGTGGAAAGCCTCA
CTTGCACTGCTGTGATCGCCCCACTACGGGCTTGATCTTCAAGGACACCTCCATCCTATCCCCC
CCTATACAAAGGTGGCAGCAAGGCCTTTGCAAGAAGAGCTCCCGTCTTTCCCAGGCCTGGCCCA
CAGAGGAGTCCACCACTGCCTTACCTCACTCTCCAGGCTAGTCTCAGGGCCTCCCTCTTTCTAC
TACTTACTACTTAAAAGTGTTCACTTTATAGAAACCTTTTTCTGTATTGGGTATGCGGCACAGG
GAGGATCTAAGCCTCCGGTCTGAGCAAGTCTTATTAAACATCTCTCTATTGCC

hide sequence

RefSeq Acc Id:

XM_008768477 ⟹ XP_008766699

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	10	105,896,477 - 105,903,301 (-)	NCBI
Rnor_6.0	10	109,796,046 - 109,802,821 (-)	NCBI

Sequence:

show sequence

GGCGAGCCGGAAGGGGTGGGAAAGGCAGGGCGCGCGCATGCGTCTTTGTAGCTGCCGGATGAGG
CGGAAGCGGAAGCCGGAAGCGCAGTCCAGGGAGCGATGGCAGCCGGTGGCGGTCTGAGCCGCTC
GGAGCGCAAAGCGGCTGAGCGGGTCCGGAGGTTGCGGGAGGAGCAGCAGCGGGAGCGCCTCCGT
CAGGTGTCACGCATCCTGAGGAAGGCGGCTGCAGAGCGCAGCGCGGAGGAGGGCCGGCTTCTAG
CTGAGAGTGAGGATCTGGTGACCGAGCTTCAGGGTCGGAGCCGGCGGCGTGAGGGCCTCAAGCG
CCGCCAGGAGGAGGTGTGTGATGACCCAGAGGAGTTGCGGAGGAAGGTCCGCGAACTAGCCGGA
GCTGTCCGAAGTGCCAGACACTTGGTTGTCTACACAGGCGCTGGGATCAGCACGGCAGCCTCTA
TCCCAGATTACCGGGGTCCTAATGGAGTGTGGACACTGCTCCAGAAAGGAAGGCCTGTGAGTGC
TGCCGACCTAAGCGAAGCAGAGCCTACCCTCACCCACATGAGCATCACCCAGCTGCACAAGCAT
AAGCTGGTGCAACACGTGGTGTCTCAGAACTGCGACGGGCTCCACCTGCGCAGTGGGCTGCCAC
GGACCGCCATCTCTGAGCTCCATGGGAATATGTATATTGAAGTGAGCAGTGCCCAGAGGACTCA
GGGCCTGGGGGACAAGCAGATGTCACTCACTGTGCCCTCTCTTCCTCAGGTCTGCACCTCCTGC
ATCCCTAACAGAGAGTACGTCCGAGTGTTTGACGTGACGGAGCGTACCGCCCTTCACCGACACC
TGACAGGCCGGACGTGCCACAAGTGTGGGACTCAGCTTCGGGACACCATTGTGCACTTTGGGGA
GAGGGGGACGCTAGGGCAGCCCCTGAACTGGGAGGCAGCGACTGAGGCCGCTAGCAAAGCAGAC
ACAATCCTGTGTTTAGGGTCCAGCTTGAAGGTACTGAAGAAGTACCCCCGTCTCTGGTGCATGA
CGAAGCCCCCAAGCCGTCGGCCCAAACTCTACATTGTGAACCTGCAGTGGACCCCGAAGGATGA
CTGGGCTGCCCTGAAGCTTCATGGGAAATGTGATGATGTAATGCGGCTCCTCATGGACGAACTG
GGCCTGGAGATCCCTGTCTACAACCGGTGGCAGGACCCAATCTTCTCCTTGGCAACTCCACTCC
GTGCTGGCGAAGAAGGTAGCCACAGTAGGAAGTCACTGTGCAGGAGCAGAGAAGAGCCCCCACC
CGGGGACCAGAGTGCCCCTCTTGCCTCAGCCACCCCCATCCTAGGAGGCTGGTTCGGCAGGGGC
TGTGCTAAGCGTGCAAAAAGGAAGAAAGCGGCGTAGCCCCGGTGTTGACAAAGAGCAGTCGGCA
CCTTGCAGATGGCTTGACCCATGTTTAGGGTCCTGTGTCACAGTGAAGGCTAGAGTGCCCCCAC
CAGATCTAGTGGAAAGAACTCTGGGGTTGGGGGTGACACTTCCTGGTGACGGTCGTTTTTAGCC
ATCTGTCCTTGTGGAAAGCCTCACTTGCACTGCTGTGATCGCCCCACTACGGGCTTGATCTTCA
AGGACACCTCCATCCTATCCCCCCCTATACAAAGGTGGCAGCAAGGCCTTTGCAAGAAGAGCTC
CCGTCTTTCCCAGGCCTGGCCCACAGAGGAGTCCACCACTGCCTTACCTCACTCTCCAGGCTAG
TCTCAGGGCCTCCCTCTTTCTACTACTTACTACTTAAAAGTGTTCACTTTATAGAAACCTTTTT
CTGTATTGGGTATGCGGCACAGGGAGGATCTAAGCCTCCGGTCTGAGCAAGTCTTATTAAACAT
CTCTCTATTGCC

hide sequence

RefSeq Acc Id:

XM_039086225 ⟹ XP_038942153

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	10	105,896,477 - 105,903,301 (-)	NCBI

RefSeq Acc Id:

XR_005489874

RefSeq Status:

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	10	105,897,029 - 105,903,301 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001100543	(Get FASTA)	NCBI Sequence Viewer
	XP_008766699	(Get FASTA)	NCBI Sequence Viewer
	XP_038942153	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAI67031	(Get FASTA)	NCBI Sequence Viewer
	B2RZ55	(Get FASTA)	NCBI Sequence Viewer
	EDM06871	(Get FASTA)	NCBI Sequence Viewer
	EDM06872	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

NP_001100543 ⟸ NM_001107073

- UniProtKB:

F1LQY4 (UniProtKB/Swiss-Prot), B2RZ55 (UniProtKB/Swiss-Prot)

- Sequence:

show sequence

MAAGGGLSRSERKAAERVRRLREEQQRERLRQVSRILRKAAAERSAEEGRLLAESEDLVTELQG
RSRRREGLKRRQEEVCDDPEELRRKVRELAGAVRSARHLVVYTGAGISTAASIPDYRGPNGVWT
LLQKGRPVSAADLSEAEPTLTHMSITQLHKHKLVQHVVSQNCDGLHLRSGLPRTAISELHGNMY
IEVCTSCIPNREYVRVFDVTERTALHRHLTGRTCHKCGTQLRDTIVHFGERGTLGQPLNWEAAT
EAASKADTILCLGSSLKVLKKYPRLWCMTKPPSRRPKLYIVNLQWTPKDDWAALKLHGKCDDVM
RLLMDELGLEIPVYNRWQDPIFSLATPLRAGEEGSHSRKSLCRSREEPPPGDQSAPLASATPIL
GGWFGRGCAKRAKRKKAA

hide sequence

RefSeq Acc Id:

XP_008766699 ⟸ XM_008768477

- Peptide Label:

isoform X1

- Sequence:

show sequence

MAAGGGLSRSERKAAERVRRLREEQQRERLRQVSRILRKAAAERSAEEGRLLAESEDLVTELQG
RSRRREGLKRRQEEVCDDPEELRRKVRELAGAVRSARHLVVYTGAGISTAASIPDYRGPNGVWT
LLQKGRPVSAADLSEAEPTLTHMSITQLHKHKLVQHVVSQNCDGLHLRSGLPRTAISELHGNMY
IEVSSAQRTQGLGDKQMSLTVPSLPQVCTSCIPNREYVRVFDVTERTALHRHLTGRTCHKCGTQ
LRDTIVHFGERGTLGQPLNWEAATEAASKADTILCLGSSLKVLKKYPRLWCMTKPPSRRPKLYI
VNLQWTPKDDWAALKLHGKCDDVMRLLMDELGLEIPVYNRWQDPIFSLATPLRAGEEGSHSRKS
LCRSREEPPPGDQSAPLASATPILGGWFGRGCAKRAKRKKAA

hide sequence

RefSeq Acc Id:

ENSRNOP00000051834 ⟸ ENSRNOT00000054951

RefSeq Acc Id:	XP_038942153 ⟸ XM_039086225
- Peptide Label:	isoform X2

RefSeq Acc Id:

ENSRNOP00000086879 ⟸ ENSRNOT00000108043

Protein Domains

Deacetylase sirtuin-type

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-B2RZ55-F1-model_v2	AlphaFold	B2RZ55	1-402	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13697969

Promoter ID:

EPDNEW_R8494

Type:

multiple initiation site

Name:

Sirt7_1

Description:

sirtuin 7

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	10	109,802,735 - 109,802,795	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1305876	AgrOrtholog
BioCyc Gene	G2FUF-22402	BioCyc
Ensembl Genes	ENSRNOG00000036683	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000051834	ENTREZGENE
	ENSRNOP00000051834.3	UniProtKB/Swiss-Prot
	ENSRNOP00000086879.1	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000054951	ENTREZGENE
	ENSRNOT00000054951.5	UniProtKB/Swiss-Prot
	ENSRNOT00000108043.1	UniProtKB/TrEMBL
Gene3D-CATH	2.20.28.200	UniProtKB/Swiss-Prot
	3.30.1600.10	UniProtKB/TrEMBL
	TPP-binding domain	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7099085	IMAGE-MGC_LOAD
InterPro	DHS-like_NAD/FAD-binding_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Sirtuin	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Sirtuin_cat_small_dom_sf	UniProtKB/TrEMBL
	Ssirtuin_cat_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:303745	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:189272	IMAGE-MGC_LOAD
NCBI Gene	303745	ENTREZGENE
PANTHER	DEACETYLASE SIRTUIN-TYPE DOMAIN-CONTAINING PROTEIN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	NAD-DEPENDENT HISTONE DEACETYLASE HST4	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	SIR2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Sirt7	PhenoGen
PROSITE	SIRTUIN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF52467	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A8I6A4L4_RAT	UniProtKB/TrEMBL
	B2RZ55	ENTREZGENE
	F1LQY4	ENTREZGENE
	SIR7_RAT	UniProtKB/Swiss-Prot
UniProt Secondary	F1LQY4	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2012-10-16	Sirt7	sirtuin 7	Sirt7	sirtuin 7 (silent mating type information regulation 2, homolog) 7 (S. cerevisiae)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	Sirt7	sirtuin 7 (silent mating type information regulation 2, homolog) 7 (S. cerevisiae)	Sirt7_predicted	sirtuin 7 (silent mating type information regulation 2, homolog) 7 (S. cerevisiae) (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-12	Sirt7_predicted	sirtuin 7 (silent mating type information regulation 2, homolog) 7 (S. cerevisiae) (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD

RGD Manual Annotations

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Imported Disease Annotations - ClinVar

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RGD Manual Annotations