Arpc2 (actin related protein 2/3 complex, subunit 2) - Rat Genome Database

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Gene: Arpc2 (actin related protein 2/3 complex, subunit 2) Rattus norvegicus
Analyze
Symbol: Arpc2
Name: actin related protein 2/3 complex, subunit 2
RGD ID: 1305848
Description: Enables several functions, including AP-1 adaptor complex binding activity; ATPase binding activity; and Arp2/3 complex binding activity. Involved in several processes, including cellular response to epidermal growth factor stimulus; cellular response to platelet-derived growth factor stimulus; and positive regulation of cellular component organization. Located in several cellular components, including actin cytoskeleton; dendrite; and distal axon. Part of filamentous actin. Is active in Schaffer collateral - CA1 synapse and postsynapse. Biomarker of silicosis. Orthologous to human ARPC2 (actin related protein 2/3 complex subunit 2); PARTICIPATES IN insulin responsive facilitative sugar transporter mediated glucose transport pathway; Rab family mediated signaling pathway; platelet-derived growth factor signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; aconitine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: actin-related protein 2/3 complex subunit 2; arp2/3 complex 34 kDa subunit; LOC301511; p34-ARC; p34Arc
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8983,269,884 - 83,300,610 (+)NCBIGRCr8
mRatBN7.2975,820,782 - 75,851,471 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl975,820,770 - 75,851,471 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx984,271,669 - 84,296,962 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0989,400,588 - 89,425,881 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0987,786,805 - 87,812,098 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0981,518,163 - 81,548,871 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl981,518,176 - 81,548,871 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0981,285,084 - 81,315,844 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4973,563,617 - 73,594,263 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1973,710,470 - 73,741,240 (+)NCBI
Celera973,397,334 - 73,427,983 (+)NCBICelera
Cytogenetic Map9q33NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
17alpha-ethynylestradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
aconitine  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
antirheumatic drug  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
bisphenol F  (ISO)
C60 fullerene  (EXP)
cadmium dichloride  (ISO)
carmustine  (ISO)
chloropicrin  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
cobalt dichloride  (ISO)
cyclosporin A  (ISO)
dextran sulfate  (ISO)
dibutyl phthalate  (EXP,ISO)
disodium selenite  (ISO)
diuron  (EXP,ISO)
doxorubicin  (ISO)
ethanol  (ISO)
folic acid  (ISO)
fonofos  (ISO)
furfural  (ISO)
genistein  (ISO)
gentamycin  (EXP)
hydrogen peroxide  (EXP)
inulin  (ISO)
ionomycin  (ISO)
ivermectin  (ISO)
lead(0)  (ISO)
methimazole  (EXP)
methylparaben  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
nickel sulfate  (ISO)
nitrates  (ISO)
Nonylphenol  (EXP)
okadaic acid  (ISO)
paracetamol  (ISO)
parathion  (ISO)
PCB138  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
permethrin  (EXP)
phenobarbital  (EXP)
phorbol 13-acetate 12-myristate  (EXP,ISO)
pyrrolidine dithiocarbamate  (ISO)
rotenone  (EXP)
SB 203580  (EXP)
silicon dioxide  (EXP)
sodium arsenate  (ISO)
sodium arsenite  (EXP)
sodium chloride  (ISO)
sodium fluoride  (ISO)
succimer  (ISO)
sulfadimethoxine  (EXP)
terbufos  (ISO)
tetrachloromethane  (ISO)
titanium dioxide  (ISO)
triphenyl phosphate  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Proteomic analysis identifies an NADPH oxidase 1 (Nox1)-mediated role for actin-related protein 2/3 complex subunit 2 (ARPC2) in promoting smooth muscle cell migration. Al Ghouleh I, etal., Int J Mol Sci. 2013 Oct 11;14(10):20220-35. doi: 10.3390/ijms141020220.
2. Coronin 1B coordinates Arp2/3 complex and cofilin activities at the leading edge. Cai L, etal., Cell. 2007 Mar 9;128(5):915-29.
3. Coronin 1B antagonizes cortactin and remodels Arp2/3-containing actin branches in lamellipodia. Cai L, etal., Cell. 2008 Sep 5;134(5):828-42. doi: 10.1016/j.cell.2008.06.054.
4. Phosphorylation of coronin 1B by protein kinase C regulates interaction with Arp2/3 and cell motility. Cai L, etal., J Biol Chem. 2005 Sep 9;280(36):31913-23. Epub 2005 Jul 18.
5. F-actin binding is essential for coronin 1B function in vivo. Cai L, etal., J Cell Sci. 2007 May 15;120(Pt 10):1779-90. Epub 2007 Apr 24.
6. A WASp-VASP complex regulates actin polymerization at the plasma membrane. Castellano F, etal., EMBO J. 2001 Oct 15;20(20):5603-14.
7. Arp2/3- and cofilin-coordinated actin dynamics is required for insulin-mediated GLUT4 translocation to the surface of muscle cells. Chiu TT, etal., Mol Biol Cell. 2010 Oct 15;21(20):3529-39. doi: 10.1091/mbc.E10-04-0316. Epub 2010 Aug 25.
8. Proteomic analysis of alternative protein tyrosine phosphorylation in 1,2-dichlorovinyl-cysteine-induced cytotoxicity in primary cultured rat renal proximal tubular cells. de Graauw M, etal., J Pharmacol Exp Ther. 2007 Jul;322(1):89-100. Epub 2007 Apr 18.
9. Synergistic interaction between the Arp2/3 complex and cofilin drives stimulated lamellipod extension. DesMarais V, etal., J Cell Sci. 2004 Jul 15;117(Pt 16):3499-510.
10. Regulated exocytosis in neuroendocrine cells: a role for subplasmalemmal Cdc42/N-WASP-induced actin filaments. Gasman S, etal., Mol Biol Cell. 2004 Feb;15(2):520-31. Epub 2003 Nov 14.
11. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
12. Specific proteins identified in whole saliva from patients with diffuse systemic sclerosis. Giusti L, etal., J Rheumatol. 2007 Oct;34(10):2063-9. Epub 2007 Aug 15.
13. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
14. Recruitment of the Arp2/3 complex and mena for the stimulation of actin polymerization in growth cones by nerve growth factor. Goldberg DJ, etal., J Neurosci Res. 2000 May 15;60(4):458-67.
15. Identification of differentially expressed genes in rat silicosis model by suppression subtractive hybridization analysis. Jin Z, etal., Acta Biochim Biophys Sin (Shanghai). 2008 Aug;40(8):740-6.
16. A multi-marker assay to distinguish malignant melanomas from benign nevi. Kashani-Sabet M, etal., Proc Natl Acad Sci U S A. 2009 Apr 14;106(15):6268-72. doi: 10.1073/pnas.0901185106. Epub 2009 Mar 30.
17. Proteomic analysis of breast cancer tissue reveals upregulation of actin-remodeling proteins and its relevance to cancer invasiveness. Kim DH, etal., Proteomics Clin Appl. 2009 Jan;3(1):30-40. doi: 10.1002/prca.200800167. Epub 2008 Nov 20.
18. Arp2/3 complex is important for filopodia formation, growth cone motility, and neuritogenesis in neuronal cells. Korobova F and Svitkina T, Mol Biol Cell. 2008 Apr;19(4):1561-74. Epub 2008 Feb 6.
19. Pair-wise comparison analysis of differential expression of mRNAs in early and advanced stage primary colorectal adenocarcinomas. Lau TP, etal., BMJ Open. 2014 Aug 8;4(8):e004930. doi: 10.1136/bmjopen-2014-004930.
20. Gadkin negatively regulates cell spreading and motility via sequestration of the actin-nucleating ARP2/3 complex. Maritzen T, etal., Proc Natl Acad Sci U S A. 2012 Jun 26;109(26):10382-7. doi: 10.1073/pnas.1206468109. Epub 2012 Jun 11.
21. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
22. Changes in the balance between caldesmon regulated by p21-activated kinases and the Arp2/3 complex govern podosome formation. Morita T, etal., J Biol Chem. 2007 Mar 16;282(11):8454-63. Epub 2007 Jan 15.
23. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
24. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
25. Breast cancer resistance protein regulates apical ectoplasmic specialization dynamics stage specifically in the rat testis. Qian X, etal., Am J Physiol Endocrinol Metab. 2013 Apr 1;304(7):E757-69. doi: 10.1152/ajpendo.00645.2012. Epub 2013 Feb 12.
26. Palladin is a regulator of actin filament bundles at the ectoplasmic specialization in adult rat testes. Qian X, etal., Endocrinology. 2013 May;154(5):1907-20. doi: 10.1210/en.2012-2269. Epub 2013 Apr 1.
27. Organization of the Arp2/3 complex in hippocampal spines. Racz B and Weinberg RJ, J Neurosci. 2008 May 28;28(22):5654-9. doi: 10.1523/JNEUROSCI.0756-08.2008.
28. GOA pipeline RGD automated data pipeline
29. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
30. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
31. Inhibition of Arp2/3-mediated actin polymerization by PICK1 regulates neuronal morphology and AMPA receptor endocytosis. Rocca DL, etal., Nat Cell Biol. 2008 Mar;10(3):259-71. doi: 10.1038/ncb1688. Epub 2008 Feb 24.
32. Role of coronin 1B in PDGF-induced migration of vascular smooth muscle cells. Williams HC, etal., Circ Res. 2012 Jun 22;111(1):56-65. doi: 10.1161/CIRCRESAHA.111.255745. Epub 2012 May 22.
33. Molecular mechanisms of invadopodium formation: the role of the N-WASP-Arp2/3 complex pathway and cofilin. Yamaguchi H, etal., J Cell Biol. 2005 Jan 31;168(3):441-52.
Additional References at PubMed
PMID:9230079   PMID:11741539   PMID:12473693   PMID:18560548   PMID:18836449   PMID:19056867   PMID:20308062   PMID:20458337   PMID:21423176   PMID:22553210   PMID:22748316   PMID:23376485  
PMID:23533145   PMID:23889934   PMID:24413018   PMID:30053369  


Genomics

Comparative Map Data
Arpc2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8983,269,884 - 83,300,610 (+)NCBIGRCr8
mRatBN7.2975,820,782 - 75,851,471 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl975,820,770 - 75,851,471 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx984,271,669 - 84,296,962 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0989,400,588 - 89,425,881 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0987,786,805 - 87,812,098 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0981,518,163 - 81,548,871 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl981,518,176 - 81,548,871 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0981,285,084 - 81,315,844 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4973,563,617 - 73,594,263 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1973,710,470 - 73,741,240 (+)NCBI
Celera973,397,334 - 73,427,983 (+)NCBICelera
Cytogenetic Map9q33NCBI
ARPC2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382218,217,189 - 218,254,348 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2218,217,141 - 218,254,356 (+)EnsemblGRCh38hg38GRCh38
GRCh372219,081,912 - 219,119,071 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362218,790,119 - 218,827,316 (+)NCBINCBI36Build 36hg18NCBI36
Build 342218,907,379 - 218,944,576NCBI
Celera2212,848,449 - 212,885,654 (+)NCBICelera
Cytogenetic Map2q35NCBI
HuRef2210,934,975 - 210,972,151 (+)NCBIHuRef
CHM1_12219,088,288 - 219,125,558 (+)NCBICHM1_1
T2T-CHM13v2.02218,702,891 - 218,740,055 (+)NCBIT2T-CHM13v2.0
Arpc2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39174,275,656 - 74,307,368 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl174,275,243 - 74,307,368 (+)EnsemblGRCm39 Ensembl
GRCm38174,236,490 - 74,268,209 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl174,236,084 - 74,268,209 (+)EnsemblGRCm38mm10GRCm38
MGSCv37174,283,124 - 74,314,787 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36174,169,706 - 74,201,416 (+)NCBIMGSCv36mm8
Celera174,797,918 - 74,829,569 (+)NCBICelera
Cytogenetic Map1C3NCBI
cM Map138.49NCBI
Arpc2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545315,116,093 - 15,146,041 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545315,117,978 - 15,145,895 (-)NCBIChiLan1.0ChiLan1.0
ARPC2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v213120,849,631 - 120,886,474 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B120,865,788 - 120,901,441 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B105,478,035 - 105,513,665 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B224,076,356 - 224,111,643 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B224,076,356 - 224,111,643 (+)Ensemblpanpan1.1panPan2
ARPC2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13724,914,389 - 24,935,998 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3724,914,642 - 24,935,824 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3725,726,741 - 25,756,145 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03724,922,615 - 24,952,042 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3724,922,535 - 24,952,248 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13724,827,991 - 24,857,388 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03724,762,177 - 24,791,643 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03724,781,773 - 24,811,231 (+)NCBIUU_Cfam_GSD_1.0
Arpc2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303174,415,593 - 174,443,979 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936569758,199 - 786,760 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936569758,358 - 786,995 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ARPC2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15120,297,025 - 120,328,542 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115120,297,122 - 120,328,795 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215133,376,755 - 133,421,942 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ARPC2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.110104,098,275 - 104,144,043 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl10104,098,402 - 104,135,791 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604095,260,455 - 95,302,739 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Arpc2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248236,774,855 - 6,804,219 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Arpc2
141 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:56
Count of miRNA genes:50
Interacting mature miRNAs:52
Transcripts:ENSRNOT00000019265
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7411571Bw138Body weight QTL 13814.30.001body mass (VT:0001259)body weight gain (CMO:0000420)93253550577535505Rat
11353957Bmd92Bone mineral density QTL 920.01tibia mineral mass (VT:1000283)volumetric bone mineral density (CMO:0001553)94611419991114199Rat
61385Edpm9Estrogen-dependent pituitary mass QTL 93.430.05pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)963869687108869687Rat
70218Cm28Cardiac mass QTL 288.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)92526804479271759Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)925268044114175309Rat
1578760Cm53Cardiac mass QTL 533.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)956771635101771635Rat
1581580Uae34Urinary albumin excretion QTL 34urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)96207227596470995Rat
12879506Pur33Proteinuria QTL 33urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)94464992189649921Rat
1354626Bvd1Brain ventricular dilatation QTL 13.730.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)975712843111552878Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)925661188100929786Rat
10058949Gmadr5Adrenal mass QTL 520.014adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)94279151387976209Rat
1578757Pur6Proteinuria QTL 63.30.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)96207227596470995Rat
631656Bp108Blood pressure QTL 1085.970.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94859825193598251Rat
2303170Bp332Blood pressure QTL 3323.730.027arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)95584784177026453Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)93696235992058970Rat
61352Bp34Blood pressure QTL 345arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94249534379271511Rat
724515Uae16Urinary albumin excretion QTL 168urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)958163035100929646Rat
731171Glom6Glomerulus QTL 62.80.0003kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)964573531109573531Rat
1598834Memor11Memory QTL 112.5exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)93696235977814038Rat
70186Niddm26Non-insulin dependent diabetes mellitus QTL 263.87blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)92207116986369743Rat
7207814Bmd91Bone mineral density QTL 913.5femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)92375414483851531Rat
6903941Pur31Proteinuria QTL 310.036urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)94019418885194188Rat
2303180Bp333Blood pressure QTL 3330.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)95662771378595166Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)93696235995410867Rat
11353949Bp393Blood pressure QTL 393arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94019418885194188Rat
11353951Bp394Blood pressure QTL 394arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94464992189649921Rat
10054125Srcrt7Stress Responsive Cort QTL 73.330.0011blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)9187073594Rat
1300134Bp185Blood pressure QTL 1853.73arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)961381434104821652Rat
7411656Foco26Food consumption QTL 269.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)93253550577535505Rat

Markers in Region
BE110216  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2975,847,832 - 75,847,994 (+)MAPPERmRatBN7.2
Rnor_6.0981,545,233 - 81,545,394NCBIRnor6.0
Rnor_5.0981,312,206 - 81,312,367UniSTSRnor5.0
RGSC_v3.4973,590,625 - 73,590,786UniSTSRGSC3.4
Celera973,424,345 - 73,424,506UniSTS
RH 3.4 Map9767.7UniSTS
Cytogenetic Map9q33UniSTS
BF397552  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2975,822,676 - 75,822,883 (+)MAPPERmRatBN7.2
Rnor_6.0981,520,076 - 81,520,282NCBIRnor6.0
Rnor_5.0981,286,979 - 81,287,185UniSTSRnor5.0
RGSC_v3.4973,565,498 - 73,565,704UniSTSRGSC3.4
Celera973,399,215 - 73,399,421UniSTS
RH 3.4 Map9706.2UniSTS
Cytogenetic Map9q33UniSTS
RH139221  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2975,821,214 - 75,821,388 (+)MAPPERmRatBN7.2
Rnor_6.0981,518,614 - 81,518,787NCBIRnor6.0
Rnor_5.0981,285,517 - 81,285,690UniSTSRnor5.0
RGSC_v3.4973,564,036 - 73,564,209UniSTSRGSC3.4
Celera973,397,753 - 73,397,926UniSTS
RH 3.4 Map9707.79UniSTS
Cytogenetic Map9q33UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000019265   ⟹   ENSRNOP00000019265
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl975,820,774 - 75,851,463 (+)Ensembl
Rnor_6.0 Ensembl981,518,195 - 81,548,871 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000077285   ⟹   ENSRNOP00000072002
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl981,535,483 - 81,548,724 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000078316
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl981,544,814 - 81,545,473 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000078317   ⟹   ENSRNOP00000074919
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl975,821,315 - 75,851,471 (+)Ensembl
Rnor_6.0 Ensembl981,518,176 - 81,548,866 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000083412
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl981,529,481 - 81,543,943 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000084309   ⟹   ENSRNOP00000074808
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl975,820,770 - 75,848,434 (+)Ensembl
Rnor_6.0 Ensembl981,518,584 - 81,548,657 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000084682   ⟹   ENSRNOP00000071740
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl975,820,917 - 75,851,466 (+)Ensembl
Rnor_6.0 Ensembl981,518,271 - 81,548,656 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000085124
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl981,548,353 - 81,548,865 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000088246   ⟹   ENSRNOP00000072262
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl975,820,774 - 75,851,078 (+)Ensembl
Rnor_6.0 Ensembl981,518,251 - 81,537,230 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000088680
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl981,527,312 - 81,528,273 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000092060
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl981,537,259 - 81,544,512 (+)Ensembl
RefSeq Acc Id: NM_001106919   ⟹   NP_001100389
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8983,269,935 - 83,300,610 (+)NCBI
mRatBN7.2975,820,796 - 75,851,471 (+)NCBI
Rnor_6.0981,518,195 - 81,548,871 (+)NCBI
Rnor_5.0981,285,084 - 81,315,844 (+)NCBI
RGSC_v3.4973,563,617 - 73,594,263 (+)RGD
Celera973,397,334 - 73,427,983 (+)RGD
Sequence:
RefSeq Acc Id: XM_006245165   ⟹   XP_006245227
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8983,269,925 - 83,300,605 (+)NCBI
mRatBN7.2975,820,800 - 75,851,466 (+)NCBI
Rnor_6.0981,518,254 - 81,548,866 (+)NCBI
Rnor_5.0981,285,084 - 81,315,844 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006245166   ⟹   XP_006245228
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8983,269,884 - 83,300,605 (+)NCBI
mRatBN7.2975,820,782 - 75,851,466 (+)NCBI
Rnor_6.0981,518,163 - 81,548,866 (+)NCBI
Rnor_5.0981,285,084 - 81,315,844 (+)NCBI
Sequence:
RefSeq Acc Id: NP_001100389   ⟸   NM_001106919
- UniProtKB: A0A0H2UHL5 (UniProtKB/TrEMBL),   A6JVT0 (UniProtKB/TrEMBL),   A0A0G2K185 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006245228   ⟸   XM_006245166
- Peptide Label: isoform X1
- UniProtKB: A0A0H2UHL5 (UniProtKB/TrEMBL),   A6JVT0 (UniProtKB/TrEMBL),   A0A0G2K185 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006245227   ⟸   XM_006245165
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000071740   ⟸   ENSRNOT00000084682
Ensembl Acc Id: ENSRNOP00000072002   ⟸   ENSRNOT00000077285
Ensembl Acc Id: ENSRNOP00000074919   ⟸   ENSRNOT00000078317
Ensembl Acc Id: ENSRNOP00000019265   ⟸   ENSRNOT00000019265
Ensembl Acc Id: ENSRNOP00000074808   ⟸   ENSRNOT00000084309
Ensembl Acc Id: ENSRNOP00000072262   ⟸   ENSRNOT00000088246

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P85970-F1-model_v2 AlphaFold P85970 1-300 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696742
Promoter ID:EPDNEW_R7267
Type:initiation region
Name:Arpc2_1
Description:actin related protein 2/3 complex, subunit 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0981,518,242 - 81,518,302EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1305848 AgrOrtholog
BioCyc Gene G2FUF-27145 BioCyc
Ensembl Genes ENSRNOG00000014289 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000019265 ENTREZGENE
  ENSRNOT00000078317 ENTREZGENE
  ENSRNOT00000084309 ENTREZGENE
Gene3D-CATH 3.30.1460.20 UniProtKB/Swiss-Prot
InterPro ARPC2 UniProtKB/Swiss-Prot
  ARPC2/4 UniProtKB/Swiss-Prot
NCBI Gene 301511 ENTREZGENE
PANTHER ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 2 UniProtKB/Swiss-Prot
  PTHR12058 UniProtKB/Swiss-Prot
Pfam P34-Arc UniProtKB/Swiss-Prot
PhenoGen Arpc2 PhenoGen
RatGTEx ENSRNOG00000014289 RatGTEx
Superfamily-SCOP SSF69645 UniProtKB/Swiss-Prot
UniProt A0A0G2K185 ENTREZGENE, UniProtKB/TrEMBL
  A0A0G2K2J1_RAT UniProtKB/TrEMBL
  A0A0G2K905 ENTREZGENE, UniProtKB/TrEMBL
  A0A0G2K9A2_RAT UniProtKB/TrEMBL
  A0A0H2UHL5 ENTREZGENE, UniProtKB/TrEMBL
  A6JVT0 ENTREZGENE, UniProtKB/TrEMBL
  ARPC2_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Arpc2  actin related protein 2/3 complex, subunit 2   Arpc2_predicted  actin related protein 2/3 complex, subunit 2 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Arpc2_predicted  actin related protein 2/3 complex, subunit 2 (predicted)      Symbol and Name status set to approved 70820 APPROVED