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Gene: Prpf31 (pre-mRNA processing factor 31) Rattus norvegicus

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Symbol:

Prpf31

Name:

pre-mRNA processing factor 31

RGD ID:

1305832

Description:

Predicted to enable several functions, including identical protein binding activity; snRNA binding activity; and snRNP binding activity. Predicted to be involved in mRNA splicing, via spliceosome and ribonucleoprotein complex localization. Predicted to act upstream of or within spliceosomal tri-snRNP complex assembly. Predicted to be located in Cajal body and nuclear speck. Predicted to be part of nucleus. Human ortholog(s) of this gene implicated in retinitis pigmentosa 11. Orthologous to human PRPF31 (pre-mRNA processing factor 31); PARTICIPATES IN retinitis pigmentosa pathway; spliceosome pathway; INTERACTS WITH 2,4-dinitrotoluene; 4,4'-sulfonyldiphenol; aconitine.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

LOC292536; PRP31 pre-mRNA processing factor 31 homolog; PRP31 pre-mRNA processing factor 31 homolog (S. cerevisiae); PRP31 pre-mRNA processing factor 31 homolog (yeast); U4/U6 small nuclear ribonucleoprotein Prp31

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	PRPF31 (pre-mRNA processing factor 31)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, Panther
Mus musculus (house mouse):	Prpf31 (pre-mRNA processing factor 31)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Prpf31 (pre-mRNA processing factor 31)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	PRPF31 (pre-mRNA processing factor 31)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	PRPF31 (pre-mRNA processing factor 31)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Prpf31 (pre-mRNA processing factor 31)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	PRPF31 (pre-mRNA processing factor 31)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	PRPF31 (pre-mRNA processing factor 31)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Prpf31 (pre-mRNA processing factor 31)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	MEIOC (meiosis specific with coiled-coil domain)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	PRPF31 (pre-mRNA processing factor 31)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Prpf31 (pre-mRNA processing factor 31)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	prpf31 (PRP31 pre-mRNA processing factor 31 homolog (yeast))	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	PRP31	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Prp31	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	prp-31	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	prpf31	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	74,491,247 - 74,502,922 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	1	74,491,247 - 74,502,922 (-)	Ensembl				GRCr8
mRatBN7.2	1	65,575,887 - 65,587,561 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	65,575,887 - 65,587,873 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	1	71,024,011 - 71,035,686 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	79,446,985 - 79,458,662 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	72,773,892 - 72,785,559 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	64,150,786 - 64,162,461 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	64,150,786 - 64,162,461 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	1	63,143,068 - 63,154,743 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	1	63,888,815 - 63,900,490 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	1	63,300,810 - 63,312,485 (-)	NCBI		Celera
RGSC_v3.1	1	63,966,376 - 63,976,668 (-)	NCBI
Cytogenetic Map	1	q12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

fundus dystrophy (ISO)

genetic disease (ISO)

Intellectual Developmental Disorder with Speech Delay, Autism, and Dysmorphic Facies (ISO)

Leber congenital amaurosis (ISO)

retinitis pigmentosa (ISO)

retinitis pigmentosa 11 (ISO,ISS)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene (ISO)

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (ISO)

2,2',4,4',5,5'-hexachlorobiphenyl (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,2',5,5'-tetrachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,4,4'-trichlorobiphenyl (ISO)

2,4-dinitrotoluene (EXP)

3,4-methylenedioxymethamphetamine (ISO)

4,4'-sulfonyldiphenol (EXP,ISO)

aconitine (EXP)

aristolochic acid A (ISO)

arsane (ISO)

arsenic atom (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP)

bisphenol AF (ISO)

bisphenol F (EXP)

caffeine (ISO)

CGP 52608 (ISO)

coumarin (ISO)

cyclosporin A (ISO)

dibutyl phthalate (ISO)

ethyl methanesulfonate (ISO)

FR900359 (ISO)

ivermectin (ISO)

mercury atom (ISO)

mercury(0) (ISO)

methyl methanesulfonate (ISO)

PCB138 (ISO)

pirinixic acid (ISO)

SB 431542 (ISO)

sodium arsenite (ISO)

tamoxifen (ISO)

tetrachloromethane (ISO)

titanium dioxide (ISO)

trimellitic anhydride (ISO)

triticonazole (EXP)

valproic acid (ISO)

vinclozolin (EXP)

Yessotoxin (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

biological_process (ND)

mRNA processing (IEA)

mRNA splicing, via spliceosome (IBA,IEA,ISO)

ribonucleoprotein complex localization (IEA,ISO)

RNA splicing (IEA)

snoRNA localization (ISO)

spliceosomal tri-snRNP complex assembly (IEA,ISO)

Cellular Component

Cajal body (IEA,ISO)

MLL1 complex (IEA,ISO)

nuclear speck (IEA,ISO)

nucleoplasm (IEA,ISO)

nucleus (IEA,ISO)

precatalytic spliceosome (IBA)

ribonucleoprotein complex (IEA)

spliceosomal complex (IEA,ISO)

spliceosomal tri-snRNP complex (IBA)

U2-type precatalytic spliceosome (IEA,ISO)

U4 snRNP (IBA,IEA,ISO)

U4/U6 x U5 tri-snRNP complex (IEA,ISO)

U4atac snRNP (IEA,ISO)

Molecular Function

identical protein binding (IEA,ISO)

protein binding (ISO)

protein-macromolecule adaptor activity (IEA,ISO)

ribonucleoprotein complex binding (IEA,ISO)

RNA binding (IEA)

snRNP binding (IEA,ISO)

U4 snRNA binding (IEA,ISO)

U4atac snRNA binding (IEA,ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

retinitis pigmentosa pathway (ISO)

spliceosome pathway (IEA,ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Genes and mutations causing retinitis pigmentosa.	Daiger SP, etal., Clin Genet. 2013 Aug;84(2):132-41. doi: 10.1111/cge.12203. Epub 2013 Jun 19.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
4.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
5.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
6.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
8.	Comprehensive gene review and curation	RGD comprehensive gene curation
9.	The spliceosome: design principles of a dynamic RNP machine.	Wahl MC, etal., Cell. 2009 Feb 20;136(4):701-18. doi: 10.1016/j.cell.2009.02.009.

Additional References at PubMed

PMID:11867543	PMID:15257298	PMID:15960975	PMID:16857676	PMID:17412961	PMID:17636026	PMID:21784869	PMID:22658674	PMID:22681889	PMID:23793891	PMID:26912367	PMID:28781166

Genomics

Comparative Map Data

Prpf31
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	74,491,247 - 74,502,922 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	1	74,491,247 - 74,502,922 (-)	Ensembl				GRCr8
mRatBN7.2	1	65,575,887 - 65,587,561 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	65,575,887 - 65,587,873 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	1	71,024,011 - 71,035,686 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	79,446,985 - 79,458,662 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	72,773,892 - 72,785,559 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	64,150,786 - 64,162,461 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	64,150,786 - 64,162,461 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	1	63,143,068 - 63,154,743 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	1	63,888,815 - 63,900,490 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	1	63,300,810 - 63,312,485 (-)	NCBI		Celera
RGSC_v3.1	1	63,966,376 - 63,976,668 (-)	NCBI
Cytogenetic Map	1	q12	NCBI

PRPF31
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	19	54,115,754 - 54,131,713 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	19	54,115,410 - 54,131,719 (+)	Ensembl			hg38	GRCh38
GRCh37	19	54,619,134 - 54,635,144 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	19	59,310,649 - 59,326,954 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	19	59,310,648 - 59,326,952	NCBI
Celera	19	51,658,851 - 51,675,215 (+)	NCBI		Celera
Cytogenetic Map	19	q13.42	NCBI
HuRef	19	50,934,999 - 50,951,328 (+)	NCBI		HuRef
CHM1_1	19	54,620,429 - 54,636,738 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	19	57,194,406 - 57,210,410 (+)	NCBI		T2T-CHM13v2.0

Prpf31
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	7	3,632,984 - 3,645,484 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	7	3,632,984 - 3,645,485 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	7	3,629,985 - 3,642,485 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	7	3,629,985 - 3,642,486 (+)	Ensembl			mm10	GRCm38
MGSCv37	7	3,581,587 - 3,594,087 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	7	3,233,072 - 3,244,804 (+)	NCBI		MGSCv36	mm8
Celera	7	3,541,905 - 3,554,404 (+)	NCBI		Celera
Cytogenetic Map	7	A1	NCBI
cM Map	7	2.09	NCBI

Prpf31
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955604	124,686 - 136,901 (-)	Ensembl
ChiLan1.0	NW_004955604	125,489 - 136,209 (-)	NCBI	ChiLan1.0	ChiLan1.0

PRPF31
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	20	60,120,119 - 60,136,430 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	19	62,042,173 - 62,058,213 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	19	51,048,133 - 51,064,394 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	19	59,891,070 - 59,907,159 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	19	59,891,070 - 59,907,159 (+)	Ensembl			panPan2	panpan1.1

PRPF31
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	1	103,073,359 - 103,090,652 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	1	103,073,380 - 103,090,652 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	1	103,135,191 - 103,152,473 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	1	103,718,743 - 103,735,835 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	1	103,718,775 - 103,737,059 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	1	103,356,788 - 103,373,861 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	1	103,118,224 - 103,135,302 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	1	103,831,964 - 103,849,246 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Prpf31
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409349	2,685,530 - 2,698,185 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936994	239,682 - 252,317 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936994	239,688 - 252,269 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PRPF31
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	55,995,091 - 56,011,441 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	6	55,995,087 - 56,011,507 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	53,206,444 - 53,223,696 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

PRPF31
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	6	46,790,193 - 46,808,946 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	6	46,793,455 - 46,808,948 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666073	26,880,019 - 26,898,743 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Prpf31
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624832	2,445,143 - 2,454,808 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624832	2,445,143 - 2,455,461 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Variants

Variants in Prpf31
104 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	93
Count of miRNA genes:	81
Interacting mature miRNAs:	84
Transcripts:	ENSRNOT00000018683
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1331732	Srn4	Serum renin concentration QTL 4	4.467		renin activity (VT:0005581)	plasma renin activity level (CMO:0000116)	1	35239598	78430678	Rat
2313059	Bss55	Bone structure and strength QTL 55	3.2	0.0001	tibia size trait (VT:0100001)	tibia midshaft cross-sectional area (CMO:0001717)	1	43284731	118944897	Rat
631688	Hcas2	Hepatocarcinoma susceptibility QTL 2	3	0.0001	liver integrity trait (VT:0010547)	liver tumorous lesion number (CMO:0001068)	1	5925874	115540829	Rat
1578649	Bmd8	Bone mineral density QTL 8	4.9		femur mineral mass (VT:0010011)	trabecular volumetric bone mineral density (CMO:0001729)	1	49393172	94393172	Rat
1358359	Sradr1	Stress Responsive Adrenal Weight QTL 1	4.74		adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	1	30882023	123479925	Rat
634314	Niddm44	Non-insulin dependent diabetes mellitus QTL 44			blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	49393289	199050459	Rat
4889929	Bss87	Bone structure and strength QTL 87	6.7		tibia area (VT:1000281)	tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)	1	53895117	82174945	Rat
1331792	Rf29	Renal function QTL 29	4.589		urine potassium amount (VT:0010539)	urine potassium level (CMO:0000128)	1	35239598	78430678	Rat
2313062	Bmd73	Bone mineral density QTL 73	3.9	0.0001	tibia mineral mass (VT:1000283)	compact volumetric bone mineral density (CMO:0001730)	1	11481312	82174945	Rat
8552900	Pigfal1	Plasma insulin-like growth factor 1 level QTL 1	7.4		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	1	34836858	79836858	Rat
1578654	Bss10	Bone structure and strength QTL 10	4		femur morphology trait (VT:0000559)	femoral neck cortical cross-sectional area (CMO:0001702)	1	49393172	159356837	Rat
1554320	Bmd1	Bone mineral density QTL 1	12.2	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	1	509108	86060548	Rat
1354643	Foco2	Food consumption QTL 2	7.17	0.0001	eating behavior trait (VT:0001431)	food intake rate (CMO:0000427)	1	33449848	78449848	Rat
2302059	Pia36	Pristane induced arthritis QTL 36	3.8	0.001	blood immunoglobulin amount (VT:0002460)	serum immunoglobulin G1 level (CMO:0002115)	1	43333002	88333002	Rat
2313065	Bss67	Bone structure and strength QTL 67	3.1	0.0001	tibia area (VT:1000281)	tibia total energy absorbed before break (CMO:0001736)	1	11481312	82174945	Rat
1357400	Bw62	Body weight QTL62	4.05		inguinal fat pad mass (VT:0010424)	inguinal fat pad weight to body weight ratio (CMO:0001253)	1	22340647	67340647	Rat
2313069	Bss68	Bone structure and strength QTL 68	2.9	0.0001	tibia size trait (VT:0100001)	tibia total energy absorbed before break (CMO:0001736)	1	11481312	82174945	Rat
631495	Bp96	Blood pressure QTL 96	4.52		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	22340647	102268831	Rat
2313075	Bss66	Bone structure and strength QTL 66	3.4	0.0001	tibia length (VT:0004357)	tibia length (CMO:0000450)	1	11481312	82174945	Rat
70225	Bp58	Blood pressure QTL 58	3.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	32356093	162846471	Rat
2298545	Neuinf8	Neuroinflammation QTL 8	4.6		nervous system integrity trait (VT:0010566)	spinal cord beta-2 microglobulin mRNA level (CMO:0002125)	1	57336763	151090257	Rat
2313072	Bss53	Bone structure and strength QTL 53	4.3	0.0001	tibia length (VT:0004357)	tibia length (CMO:0000450)	1	43284731	118944897	Rat
1300167	Hrtrt2	Heart rate QTL 2	4.35		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	1	11481312	75088344	Rat
10059597	Bp377	Blood pressure QTL 377	3.42	0.025	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	32737458	199368955	Rat
2313078	Bss54	Bone structure and strength QTL 54	3.5	0.0001	tibia area (VT:1000281)	tibia midshaft cross-sectional area (CMO:0001717)	1	43284731	118944897	Rat
2313077	Bss69	Bone structure and strength QTL 69	3.5	0.0001	tibia strength trait (VT:1000284)	bone polar moment of inertia (CMO:0001558)	1	11481312	82174945	Rat
1331778	Rf28	Renal function QTL 28	4.66		urine potassium amount (VT:0010539)	urine potassium excretion rate (CMO:0000761)	1	45803140	78430678	Rat
2313402	Anxrr24	Anxiety related response QTL 24			aggression-related behavior trait (VT:0015014)	tameness/aggressiveness composite score (CMO:0002136)	1	48963584	144267916	Rat
1331785	Rf27	Renal function QTL 27	4.643		urine sodium amount (VT:0006274)	urine sodium level (CMO:0000129)	1	28879780	78430678	Rat
61342	Bp27	Blood pressure QTL 27	3.4	0.0006	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	56732668	98773277	Rat
1300172	Bp172	Blood pressure QTL 172	3.56		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	1	32737273	90665040	Rat
4889962	Bss94	Bone structure and strength QTL 94	3.8		tibia area (VT:1000281)	tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)	1	49361465	82174945	Rat
724520	Bp145	Blood pressure QTL 145	2.1	0.0024	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	20784828	65784828	Rat
2313094	Bss58	Bone structure and strength QTL 58	3.7	0.0001	tibia strength trait (VT:1000284)	tibia total energy absorbed before break (CMO:0001736)	1	43284731	118944897	Rat
6903308	Scl36	Serum cholesterol QTL 36	2	0.0125	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	1	53863041	90532583	Rat
2313092	Bmd72	Bone mineral density QTL 72	2.5	0.0001	tibia mineral mass (VT:1000283)	total volumetric bone mineral density (CMO:0001728)	1	11481312	82174945	Rat
2300164	Bmd44	Bone mineral density QTL 44	5.4	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	1	56949932	101949932	Rat
2313099	Bss56	Bone structure and strength QTL 56	2.4	0.0001	tibia size trait (VT:0100001)	tibia midshaft endosteal cross-sectional area (CMO:0001716)	1	43284731	118944897	Rat
2313098	Bmd70	Bone mineral density QTL 70	3.6	0.0001	tibia mineral mass (VT:1000283)	compact volumetric bone mineral density (CMO:0001730)	1	43284731	118944897	Rat
2313097	Bss70	Bone structure and strength QTL 70	3.5	0.0001	tibia strength trait (VT:1000284)	tibia total energy absorbed before break (CMO:0001736)	1	11481312	82174945	Rat
9589820	Insglur3	Insulin/glucose ratio QTL 3	10.75	0.001	blood insulin amount (VT:0001560)	calculated plasma insulin level (CMO:0002170)	1	34836858	79836858	Rat
152025249	Scl82	Serum cholesterol level QTL 82	4.77		blood cholesterol amount (VT:0000180)		1	50343510	99980958	Rat
738020	Pia8	Pristane induced arthritis QTL 8	4.7		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	1	1	65833076	Rat
1354599	Bw29	Body weight QTL 29	3.46	0.001	body mass (VT:0001259)	body weight (CMO:0000012)	1	33449848	78449848	Rat
4889919	Bss86	Bone structure and strength QTL 86	4.1		tibia area (VT:1000281)	tibia midshaft total cross-sectional area (CMO:0001715)	1	53895117	82174945	Rat
8552948	Pigfal11	Plasma insulin-like growth factor 1 level QTL 11	4.7		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	1	34836858	79836858	Rat
2313051	Bss57	Bone structure and strength QTL 57	3.7	0.0001	tibia strength trait (VT:1000284)	bone polar moment of inertia (CMO:0001558)	1	43284731	118944897	Rat

Markers in Region

UniSTS:235586

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	1	65,576,535 - 65,576,736 (+)	MAPPER	mRatBN7.2
Rnor_6.0	1	64,151,436 - 64,151,636	NCBI	Rnor6.0
Rnor_5.0	1	63,143,718 - 63,143,918	UniSTS	Rnor5.0
RGSC_v3.4	1	63,889,465 - 63,889,665	UniSTS	RGSC3.4
Celera	1	63,301,460 - 63,301,660	UniSTS
Cytogenetic Map	1	q12	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	164	91	90	59	92	59	6	356	192	11	143	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001106219	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC103574	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474101	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000001	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000091739 ⟹ ENSRNOP00000072903

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	1	74,491,247 - 74,502,922 (-)	Ensembl
mRatBN7.2 Ensembl	1	65,575,887 - 65,584,466 (-)	Ensembl
Rnor_6.0 Ensembl	1	64,150,786 - 64,162,461 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000099681 ⟹ ENSRNOP00000096697

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	1	65,576,602 - 65,587,873 (-)	Ensembl

RefSeq Acc Id:

NM_001106219 ⟹ NP_001099689

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	74,491,247 - 74,502,922 (-)	NCBI
mRatBN7.2	1	65,575,887 - 65,587,561 (-)	NCBI
Rnor_6.0	1	64,150,786 - 64,162,461 (-)	NCBI
Rnor_5.0	1	63,143,068 - 63,154,743 (-)	NCBI
RGSC_v3.4	1	63,888,815 - 63,900,490 (-)	RGD
Celera	1	63,300,810 - 63,312,485 (-)	RGD

Sequence:

show sequence

GTAAAGCGTCATCAAAGAGCGCCGAAGCTCTGGGGAAGCGGATTTCTTAGAAACGATCGTGAGA
GGATTGAAGCGGTCTTGGGATGTCGCTGGCAGATGAGCTCTTGGCTGACCTTGAGGAGGCAGCA
GAAGAAGAAGAAGGAGGAAGCTATGGAGAAGAAGAGGAGGAGCCAGCAATTGAGGATGTACAAG
AGGAGACACAACTGGATCTTTCTGGAGATTCAGTCAAGAGCATTGCCAAGCTATGGGATAGCAA
GATGTTTGCTGAGATCATGATGAAGATTGAGGAGTATATCAGCAAGCAAGCCAAAGCTTCAGAA
GTGATGGGACCGGTGGAGGCAGCCCCTGAGTACCGAGTCATTGTGGATGCCAACAACCTGACTG
TGGAGATAGAAAACGAGCTGAACATTATCCATAAGTTCATCCGGGATAAATACTCAAAGAGATT
CCCTGAGCTAGAATCCTTGGTGCCCAACGCTCTGGATTACATCCGCACAGTCAAGGAACTGGGC
AACAGCCTGGATAAGTGTAAGAACAATGAGAATCTCCAGCAGATCCTGACCAATGCTACCATCA
TGGTTGTTAGTGTTACTGCCTCTACCACCCAGGGGCAGCAGCTGTCAGATGAGGAACTAGAGCG
ACTAGAGGAGGCCTGTGACATGGCACTGGAGCTGAATGCCTCCAAGCACCGCATCTATGAGTAC
GTGGAGTCCCGGATGTCGTTCATTGCACCCAACTTGTCCATCATCATTGGAGCTTCCACGGCTG
CCAAGATCATGGGTGTGGCTGGAGGGCTGACCAACCTGTCTAAGATGCCTGCCTGCAACATCAT
GCTGTTGGGAGCCCAGCGCAAGACACTGTCTGGCTTCTCTTCTACCTCAGTGCTGCCTCACACT
GGCTACATCTACCACAGTGACATTGTGCAGTCTCTGCCCCCAGATCTTCGGCGGAAGGCAGCCC
GCCTAGTGGCTGCCAAATGTACACTGGCAGCTCGTGTGGACAGTTTCCATGAGAGCACAGAGGG
GAAGGTGGGCTATGAACTAAAGGACGAGATTGAGCGCAAGTTTGACAAGTGGCAGGAGCCACCA
CCTGTGAAGCAGGTGAAGCCCCTGCCTGCACCCCTTGATGGGCAGCGGAAGAAGCGAGGGGGCC
GAAGGTACCGCAAGATGAAAGAACGGCTAGGACTGACTGAGATCCGGAAGCAGGCCAACCGCAT
GAGCTTTGGAGAGATTGAGGAGGATGCCTATCAAGAAGACCTGGGCTTTAGCCTGGGCCACTTG
GGCAAGTCAGGCAGTGGGCGTGTGCGGCAGACACAGGTGAATGAGGCCACCAAGGCTAGGATCT
CCAAGACACTACAGCGGACCTTACAGAAACAGAGTGTGGTGTATGGTGGGAAGTCAACAATTCG
TGACCGCTCCTCGGGGACTGCCTCTAGTGTGGCCTTCACTCCACTCCAGGGTCTGGAGATTGTG
AACCCACAAGCAGCCGAGAAGAAGGTGGCAGAGGCCAATCAGAAGTATTTCTCTAGCATGGCCG
AGTTCCTCAAGGTCAAGGGTGAGAAAAGTGGCACCATGTCTACTTGAAGGGGCCCACAGCCCAG
GTGGCCATCCACTGAAAGGACATAAAGGACTGGAGCTTCTGAAGTGACAGATATCCAGCCAGGA
AGTTTGGTGTGGTGGAGGCAGCCTTCCATGCTCTGTCCTTGGCCCAAGGCCACAGCATCCAAGA
AAAGGATGAAGAACCTTAGCCTGTCTCCCCCAGCACTCATGCTGCTGCTGTTCCAATCGGGCAG
GAAGGTCTTCCACACACTCAGCTTTTTTACTTACAGGGGAAAAAGGAAGTGCTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTAGACTGAATACAATTAAATGCATAGTGTCTAGCTCTGAACAGAGGG
TATGATTTGTTTATGAAAGAACCAGAGGACTCAGAGCTGTGGGGCTTCCAGAGTGAGTAGCATG
GACCCAGCTCTCTTTTGCTCTTGTCCTGGAATCTAAGAAAAACCCTGTCTATCTCTTAACACCA
CACTTAATGAGAACATCAGCATCATGGCCAAACAGTATGGCCACCACAAAATTCCGGACCCAAC
AAGAGCCAGAGGATTATTGTCCCTCAGGCTAGAAACTTCACCCACACAAAGTGAAGCACCTAAA
AGGTTTGGGAAGTATGTTCAGAAAGCACCACCCAGTACTGCATTCATGGTGCAGCCTATTTTTA
ATTCATGTTCGTTAGGGGGCCACACCTAGGTCCTCAGCAAGGGTGAGGCAAGTGGGTACCCTGC
CCTATGAGGTACCAATGCCAGGTAAGCAAAAGAAGTGCAGTGCACACTACCCAGTTTGATTTGC
AAACTGGGGCTTCATCAAGGGAAAAGAAGAACAGTG

hide sequence

Protein Sequences


Protein RefSeqs	NP_001099689	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDL84934	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000072903
	ENSRNOP00000072903.2
	ENSRNOP00000096697.1

RefSeq Acc Id:

NP_001099689 ⟸ NM_001106219

- UniProtKB:

A0A8I6GLQ3 (UniProtKB/TrEMBL), A6KS26 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MSLADELLADLEEAAEEEEGGSYGEEEEEPAIEDVQEETQLDLSGDSVKSIAKLWDSKMFAEIM
MKIEEYISKQAKASEVMGPVEAAPEYRVIVDANNLTVEIENELNIIHKFIRDKYSKRFPELESL
VPNALDYIRTVKELGNSLDKCKNNENLQQILTNATIMVVSVTASTTQGQQLSDEELERLEEACD
MALELNASKHRIYEYVESRMSFIAPNLSIIIGASTAAKIMGVAGGLTNLSKMPACNIMLLGAQR
KTLSGFSSTSVLPHTGYIYHSDIVQSLPPDLRRKAARLVAAKCTLAARVDSFHESTEGKVGYEL
KDEIERKFDKWQEPPPVKQVKPLPAPLDGQRKKRGGRRYRKMKERLGLTEIRKQANRMSFGEIE
EDAYQEDLGFSLGHLGKSGSGRVRQTQVNEATKARISKTLQRTLQKQSVVYGGKSTIRDRSSGT
ASSVAFTPLQGLEIVNPQAAEKKVAEANQKYFSSMAEFLKVKGEKSGTMST

hide sequence

Ensembl Acc Id:

ENSRNOP00000072903 ⟸ ENSRNOT00000091739

Ensembl Acc Id:

ENSRNOP00000096697 ⟸ ENSRNOT00000099681

Protein Domains

Nop

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D3ZI68-F1-model_v2	AlphaFold	D3ZI68	1-499	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13689663

Promoter ID:

EPDNEW_R188

Type:

initiation region

Name:

Prpf31_1

Description:

pre-mRNA processing factor 31

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	1	64,162,451 - 64,162,511	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1305832	AgrOrtholog
BioCyc Gene	G2FUF-61035	BioCyc
Ensembl Genes	ENSRNOG00000061039	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000091739	ENTREZGENE
	ENSRNOT00000091739.2	UniProtKB/TrEMBL
	ENSRNOT00000099681.1	UniProtKB/TrEMBL
Gene3D-CATH	1.10.246.90	UniProtKB/TrEMBL
	1.10.287.4070	UniProtKB/TrEMBL
InterPro	Nop_C	UniProtKB/TrEMBL
	Nop_dom_sf	UniProtKB/TrEMBL
	NOSIC	UniProtKB/TrEMBL
	Prp31	UniProtKB/TrEMBL
	Prp31_C	UniProtKB/TrEMBL
	SnoRNA-bd_dom	UniProtKB/TrEMBL
KEGG Report	rno:292536	UniProtKB/TrEMBL
NCBI Gene	292536	ENTREZGENE
PANTHER	PTHR13904	UniProtKB/TrEMBL
	U4/U6 SMALL NUCLEAR RIBONUCLEOPROTEIN PRP31	UniProtKB/TrEMBL
Pfam	Nop	UniProtKB/TrEMBL
	Prp31_C	UniProtKB/TrEMBL
PhenoGen	Prpf31	PhenoGen
PROSITE	NOP	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000061039	RatGTEx
SMART	NOSIC	UniProtKB/TrEMBL
Superfamily-SCOP	SSF89124	UniProtKB/TrEMBL
UniProt	A0A8I6GLQ3	ENTREZGENE, UniProtKB/TrEMBL
	A6KS26	ENTREZGENE, UniProtKB/TrEMBL
	D3ZI68_RAT	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2013-07-09	Prpf31	pre-mRNA processing factor 31	Prpf31	PRP31 pre-mRNA processing factor 31 homolog (S. cerevisiae)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-10-24	Prpf31	PRP31 pre-mRNA processing factor 31 homolog (S. cerevisiae)	Prpf31	PRP31 pre-mRNA processing factor 31 homolog (yeast)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	Prpf31	PRP31 pre-mRNA processing factor 31 homolog (yeast)	Prpf31_predicted	PRP31 pre-mRNA processing factor 31 homolog (yeast) (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-12	Prpf31_predicted	PRP31 pre-mRNA processing factor 31 homolog (yeast) (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - MGI

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - MGI

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - KEGG (archival)