Stat4 (signal transducer and activator of transcription 4) - Rat Genome Database

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Gene: Stat4 (signal transducer and activator of transcription 4) Rattus norvegicus
Symbol: Stat4
Name: signal transducer and activator of transcription 4
RGD ID: 1305747
Description: Enables sequence-specific DNA binding activity. Acts upstream of or within cellular response to cytokine stimulus and cellular response to organic cyclic compound. Predicted to be part of RNA polymerase II transcription regulator complex. Predicted to be active in nucleus. Used to study obesity. Biomarker of asthma and chronic obstructive pulmonary disease. Human ortholog(s) of this gene implicated in several diseases, including IgA glomerulonephritis; autoimmune disease (multiple); breast cancer (multiple); carcinoma (multiple); and scleroderma (multiple). Orthologous to several human genes including STAT1 (signal transducer and activator of transcription 1); PARTICIPATES IN interleukin-12 signaling pathway; interleukin-23 signaling pathway; interleukin-27 signaling pathway; INTERACTS WITH 7,12-dimethyltetraphene; acetamide; aconitine.
Type: protein-coding
Previously known as: LOC367264
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr8956,964,617 - 57,080,523 (-)NCBIGRCr8
mRatBN7.2949,472,660 - 49,588,540 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl949,419,340 - 49,588,540 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx958,021,896 - 58,130,745 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0963,144,732 - 63,253,572 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0961,440,716 - 61,549,562 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0954,340,649 - 54,457,753 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl954,287,541 - 54,484,533 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0954,051,154 - 54,167,491 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4946,510,251 - 46,650,076 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1946,511,665 - 46,651,490 (-)NCBI
Celera947,135,713 - 47,243,684 (-)NCBICelera
Cytogenetic Map9q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-amphetamine  (ISO)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
6alpha-methylprednisolone  (ISO)
7,12-dimethyltetraphene  (EXP)
acetamide  (EXP)
aconitine  (EXP)
acrylamide  (EXP)
ammonium chloride  (EXP)
antigen  (ISO)
antimycin A  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
azoxystrobin  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
buta-1,3-diene  (ISO)
carbon nanotube  (ISO)
choline  (ISO)
cisplatin  (ISO)
crocidolite asbestos  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
cypermethrin  (EXP,ISO)
deguelin  (ISO)
deoxynivalenol  (ISO)
diarsenic trioxide  (ISO)
diclofenac  (ISO)
disodium selenite  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
eugenol  (ISO)
folic acid  (ISO)
genistein  (ISO)
gentamycin  (EXP)
L-methionine  (ISO)
leptomycin B  (ISO)
lipopolysaccharide  (ISO)
maneb  (ISO)
melatonin  (ISO)
methotrexate  (ISO)
N-methyl-N-nitrosourea  (ISO)
nickel atom  (ISO)
nickel sulfate  (ISO)
ochratoxin A  (ISO)
ozone  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
perfluorooctanoic acid  (ISO)
phenytoin  (ISO)
picoxystrobin  (ISO)
piroxicam  (ISO)
prednisolone  (ISO)
propanal  (ISO)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sunitinib  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
toluene  (ISO)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View

References - curated
# Reference Title Reference Citation
1. Disease susceptibility genes shared by primary biliary cirrhosis and Crohn's disease in the Japanese population. Aiba Y, etal., J Hum Genet. 2015 Sep;60(9):525-31. doi: 10.1038/jhg.2015.59. Epub 2015 Jun 18.
2. Further evidence of subphenotype association with systemic lupus erythematosus susceptibility loci: a European cases only study. Alonso-Perez E, etal., PLoS One. 2012;7(9):e45356. doi: 10.1371/journal.pone.0045356. Epub 2012 Sep 26.
3. Simvastatin treatment ameliorates autoimmune disease associated with accelerated atherosclerosis in a murine lupus model. Aprahamian T, etal., J Immunol. 2006 Sep 1;177(5):3028-34.
4. Inactivation of the transcription factor STAT-4 prevents inflammation-driven fibrosis in animal models of systemic sclerosis. Avouac J, etal., Arthritis Rheum. 2011 Mar;63(3):800-9. doi: 10.1002/art.30171.
5. Role of Stat4-mediated signal transduction events in the generation of aggressor CD4+ T cells in herpetic stromal keratitis pathogenesis. Banerjee K, etal., J Interferon Cytokine Res. 2007 Jan;27(1):65-75.
6. Comprehensive assessment of rheumatoid arthritis susceptibility loci in a large psoriatic arthritis cohort. Bowes J, etal., Ann Rheum Dis. 2012 Aug;71(8):1350-4. doi: 10.1136/annrheumdis-2011-200802. Epub 2012 Feb 10.
7. Evidence for activation of inflammatory lipoxygenase pathways in visceral adipose tissue of obese Zucker rats. Chakrabarti SK, etal., Am J Physiol Endocrinol Metab. 2011 Jan;300(1):E175-87. Epub 2010 Oct 26.
8. Chronic exposure to staphylococcal superantigen elicits a systemic inflammatory disease mimicking lupus. Chowdhary VR, etal., J Immunol. 2012 Aug 15;189(4):2054-62. doi: 10.4049/jimmunol.1201097. Epub 2012 Jul 13.
9. STAT4 is a genetic risk factor for systemic sclerosis having additive effects with IRF5 on disease susceptibility and related pulmonary fibrosis. Dieude P, etal., Arthritis Rheum. 2009 Aug;60(8):2472-9. doi: 10.1002/art.24688.
10. Jak-Stat signaling pathway may play a role in the pathogenesis of cholesteatoma. Eskiizmir G, etal., Am J Otolaryngol. 2014 Mar-Apr;35(2):130-6. doi: 10.1016/j.amjoto.2013.10.005. Epub 2013 Oct 30.
11. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
12. STAT4 is a confirmed genetic risk factor for Sjogren's syndrome and could be involved in type 1 interferon pathway signaling. Gestermann N, etal., Genes Immun. 2010 Jul;11(5):432-8. doi: 10.1038/gene.2010.29. Epub 2010 Jun 10.
13. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
14. Polymorphisms in TBX21 and STAT4 increase the risk of systemic sclerosis: evidence of possible gene-gene interaction and alterations in Th1/Th2 cytokines. Gourh P, etal., Arthritis Rheum. 2009 Dec;60(12):3794-806. doi: 10.1002/art.24958.
15. Polymorphisms of signal transducers and activators of transcription 1 and 4 (STAT1 and STAT4) contribute to progression of childhood IgA nephropathy. Hahn WH, etal., Cytokine. 2010 Apr;50(1):69-74. doi: 10.1016/j.cyto.2009.12.004. Epub 2010 Jan 4.
16. Disruption of the STAT4 signaling pathway protects from autoimmune diabetes while retaining antiviral immune competence. Holz A, etal., J Immunol. 1999 Nov 15;163(10):5374-82.
17. Identification of a susceptibility locus in STAT4 for Behcet's disease in Han Chinese in a genome-wide association study. Hou S, etal., Arthritis Rheum. 2012 Dec;64(12):4104-13. doi: 10.1002/art.37708.
18. STAT4 polymorphism in a Chinese Han population with Vogt-Koyanagi-Harada syndrome and Behcet's disease. Hu K, etal., Hum Immunol. 2010 Jul;71(7):723-6. doi: 10.1016/j.humimm.2010.04.007. Epub 2010 May 14.
19. STAT expression and localization in the central nervous system during autoimmune encephalomyelitis in Lewis rats. Jee Y, etal., J Neuroimmunol. 2001 Mar 1;114(1-2):40-7.
20. STAT4 gene polymorphisms are associated with susceptibility and ANA status in primary biliary cirrhosis. Joshita S, etal., Dis Markers. 2014;2014:727393. doi: 10.1155/2014/727393. Epub 2014 Feb 4.
21. Role of STAT4 polymorphisms in systemic lupus erythematosus in a Japanese population: a case-control association study of the STAT1-STAT4 region. Kawasaki A, etal., Arthritis Res Ther. 2008;10(5):R113. doi: 10.1186/ar2516. Epub 2008 Sep 19.
22. Signaling through the JAK/STAT pathway, recent advances and future challenges. Kisseleva T, etal., Gene 2002 Feb 20;285(1-2):1-24.
23. Variant form of STAT4 is associated with primary Sjogren's syndrome. Korman BD, etal., Genes Immun. 2008 Apr;9(3):267-70. doi: 10.1038/gene.2008.1. Epub 2008 Feb 14.
24. Favored T helper 1 response in a mouse model of hepatosteatosis is associated with enhanced T cell-mediated hepatitis. Kremer M, etal., Hepatology. 2006 Jul;44(1):216-27. doi: 10.1002/hep.21221.
25. Differential requirement of signal transducer and activator of transcription-4 (Stat4) and Stat6 in a thyrotropin receptor-289-adenovirus-induced model of Graves' hyperthyroidism. Land KJ, etal., Endocrinology. 2006 Jan;147(1):111-9. Epub 2005 Sep 29.
26. [Effect of Radix Astragali on signal transducer and activator of transcription activator-4 and its mRNA expression in a rat model of asthma] Li CC, etal., Zhonghua Er Ke Za Zhi. 2007 Oct;45(10):727-31.
27. Association of STAT4 and PTPN22 polymorphisms and their interactions with type-1 autoimmune hepatitis susceptibility in Chinese Han children. Li X, etal., Oncotarget. 2017 Apr 27;8(37):60933-60940. doi: 10.18632/oncotarget.17458. eCollection 2017 Sep 22.
28. STAT4 genetic polymorphisms association with spontaneous clearance of hepatitis B virus infection. Lu Y, etal., Immunol Res. 2015 Jun;62(2):146-52. doi: 10.1007/s12026-015-8645-1.
29. JANEX-1, a JAK3 inhibitor, protects pancreatic islets from cytokine toxicity through downregulation of NF-kappaB activation and the JAK/STAT pathway. Lv N, etal., Exp Cell Res. 2009 Jul 15;315(12):2064-71. doi: 10.1016/j.yexcr.2009.04.021. Epub 2009 May 3.
30. Pivotal role of signal transducer and activator of transcription (Stat)4 and Stat6 in the innate immune response during sepsis. Matsukawa A, etal., J Exp Med. 2001 Mar 19;193(6):679-88.
31. Targeting transcription factor Stat4 uncovers a role for interleukin-18 in the pathogenesis of severe lupus nephritis in mice. Menke J, etal., Kidney Int. 2011 Feb;79(4):452-63. Epub 2010 Oct 27.
32. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
33. The JAK-STAT signaling pathway: input and output integration. Murray PJ J Immunol. 2007 Mar 1;178(5):2623-9.
34. Quantitative PCR on 5 genes reliably identifies CTCL patients with 5% to 99% circulating tumor cells with 90% accuracy. Nebozhyn M, etal., Blood. 2006 Apr 15;107(8):3189-96. Epub 2006 Jan 10.
35. STAT4 is critical for immunity but not for antileishmanial activity of antimonials in experimental visceral leishmaniasis. Oghumu S, etal., Eur J Immunol. 2014 Feb;44(2):450-9. doi: 10.1002/eji.201343477. Epub 2013 Nov 15.
36. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
37. Influence of STAT4 polymorphism in primary Sjogren's syndrome. Palomino-Morales RJ, etal., J Rheumatol. 2010 May;37(5):1016-9. doi: 10.3899/jrheum.091007. Epub 2010 Apr 1.
38. Activation of the 12-lipoxygenase and signal transducer and activator of transcription pathway during neointima formation in a model of the metabolic syndrome. Pei H, etal., Am J Physiol Endocrinol Metab. 2006 Jan;290(1):E92-E102. Epub 2005 Aug 23.
39. Contribution of STAT4 gene single-nucleotide polymorphism to systemic lupus erythematosus in the Polish population. Piotrowski P, etal., Mol Biol Rep. 2012 Sep;39(9):8861-6. doi: 10.1007/s11033-012-1752-3. Epub 2012 Jun 24.
40. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
41. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
42. GOA pipeline RGD automated data pipeline
43. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
44. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
45. Comprehensive gene review and curation RGD comprehensive gene curation
46. Peptide YY attenuates STAT1 and STAT3 activation induced by TNF-alpha in acinar cell line AR42J. Robinson K, etal., J Am Coll Surg. 2006 May;202(5):788-96.
47. Cytokine and chemokine expression associated with steatohepatitis and hepatocyte proliferation in rats fed ethanol via total enteral nutrition. Ronis MJ, etal., Exp Biol Med (Maywood). 2008 Mar;233(3):344-55. doi: 10.3181/0707-RM-203.
48. The STAT4 gene influences the genetic predisposition to systemic sclerosis phenotype. Rueda B, etal., Hum Mol Genet. 2009 Jun 1;18(11):2071-7. doi: 10.1093/hmg/ddp119. Epub 2009 Mar 13.
49. Phenotypic associations of genetic susceptibility loci in systemic lupus erythematosus. Sanchez E, etal., Ann Rheum Dis. 2011 Jun 30.
50. Association of variants in innate immune genes with asthma and eczema. Sharma S, etal., Pediatr Allergy Immunol. 2012 Jun;23(4):315-23. doi: 10.1111/j.1399-3038.2011.01243.x. Epub 2011 Dec 23.
51. JAK/STAT/SOCS-signaling pathway and colon and rectal cancer. Slattery ML, etal., Mol Carcinog. 2013 Feb;52(2):155-66. doi: 10.1002/mc.21841. Epub 2011 Nov 28.
52. STAT-4 mediated IL-12 signaling pathway is critical for the development of protective immunity in cutaneous leishmaniasis. Stamm LM, etal., Eur J Immunol. 1999 Aug;29(8):2524-9.
53. Positive association between STAT4 polymorphisms and polymyositis/dermatomyositis in a Japanese population. Sugiura T, etal., Ann Rheum Dis. 2012 Oct;71(10):1646-50. doi: 10.1136/annrheumdis-2011-200839. Epub 2012 Mar 8.
54. Association between a C8orf13-BLK polymorphism and polymyositis/dermatomyositis in the Japanese population: an additive effect with STAT4 on disease susceptibility. Sugiura T, etal., PLoS One. 2014 Mar 14;9(3):e90019. doi: 10.1371/journal.pone.0090019. eCollection 2014.
55. STAT4 regulates antiviral gamma interferon responses and recurrent disease during herpes simplex virus 2 infection. Svensson A, etal., J Virol. 2012 Sep;86(17):9409-15. doi: 10.1128/JVI.00947-12. Epub 2012 Jun 20.
56. Specificity of the STAT4 genetic association for severe disease manifestations of systemic lupus erythematosus. Taylor KE, etal., PLoS Genet. 2008 May 30;4(5):e1000084. doi: 10.1371/journal.pgen.1000084.
57. Genetic risk factors in lupus nephritis and IgA nephropathy--no support of an overlap. Vuong MT, etal., PLoS One. 2010 May 10;5(5):e10559. doi: 10.1371/journal.pone.0010559.
58. [Relationship of reduced lung function with Th1/Th2 polarization, STAT4/6 expression in rats of chronic obstructive pulmonary disease]. Wang C and Li Z, Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2013 Dec;29(12):1233-6.
59. STAT4 knockout mice are more susceptible to concanavalin A-induced T-cell hepatitis. Wang Y, etal., Am J Pathol. 2014 Jun;184(6):1785-94. doi: 10.1016/j.ajpath.2014.02.023. Epub 2014 Apr 13.
60. Polymorphisms in STAT4 increase the risk of acute renal allograft rejection in the Chinese population. Yang H, etal., Transpl Immunol. 2011 May;24(4):216-9. doi: 10.1016/j.trim.2011.01.001. Epub 2011 Jan 13.
61. STAT4 is a genetic risk factor for systemic sclerosis in a Chinese population. Yi L, etal., Int J Immunopathol Pharmacol. 2013 Apr-Jun;26(2):473-8.
62. Role of hepatic resident and infiltrating macrophages in liver repair after acute injury. You Q, etal., Biochem Pharmacol. 2013 Sep 15;86(6):836-43. doi: 10.1016/j.bcp.2013.07.006. Epub 2013 Jul 19.
63. STAT4 gene polymorphism is associated with psoriasis in the genetically homogeneous population of Crete, Greece. Zervou MI, etal., Hum Immunol. 2009 Sep;70(9):738-41. doi: 10.1016/j.humimm.2009.05.008. Epub 2009 Jun 17.
64. [Single nucleotide polymorphism of STAT4 rs7574865 is associated with the susceptibility of primary biliary cirrhosis in Han population of partial regions of Jiangsu province]. Zheng L and Zhou H, Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2017 Apr;33(4):521-525.
Additional References at PubMed
PMID:11489994   PMID:11894097   PMID:12213961   PMID:12372421   PMID:12477932   PMID:18591661   PMID:19666510   PMID:20399120   PMID:20861313   PMID:22851706   PMID:23772023   PMID:30848408  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr8956,964,617 - 57,080,523 (-)NCBIGRCr8
mRatBN7.2949,472,660 - 49,588,540 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl949,419,340 - 49,588,540 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx958,021,896 - 58,130,745 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0963,144,732 - 63,253,572 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0961,440,716 - 61,549,562 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0954,340,649 - 54,457,753 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl954,287,541 - 54,484,533 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0954,051,154 - 54,167,491 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4946,510,251 - 46,650,076 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1946,511,665 - 46,651,490 (-)NCBI
Celera947,135,713 - 47,243,684 (-)NCBICelera
Cytogenetic Map9q22NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh382191,029,576 - 191,151,596 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2191,029,576 - 191,151,596 (-)EnsemblGRCh38hg38GRCh38
GRCh372191,894,302 - 192,016,322 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362191,602,551 - 191,724,170 (-)NCBINCBI36Build 36hg18NCBI36
Build 342191,719,811 - 191,841,431NCBI
Celera2185,488,908 - 185,610,548 (-)NCBICelera
Cytogenetic Map2q32.2-q32.3NCBI
HuRef2183,753,956 - 183,875,743 (-)NCBIHuRef
CHM1_12191,900,128 - 192,022,113 (-)NCBICHM1_1
T2T-CHM13v2.02191,518,699 - 191,663,236 (-)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39152,026,265 - 52,146,348 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl152,026,307 - 52,146,348 (+)EnsemblGRCm39 Ensembl
GRCm38151,987,106 - 52,107,189 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl151,987,148 - 52,107,189 (+)EnsemblGRCm38mm10GRCm38
MGSCv37152,065,088 - 52,164,028 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36151,952,789 - 52,051,729 (+)NCBIMGSCv36mm8
Celera152,546,764 - 52,645,629 (+)NCBICelera
Cytogenetic Map1C1.1NCBI
cM Map126.67NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_0049554038,061,471 - 8,144,276 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554038,061,471 - 8,144,252 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan1-v21393,711,969 - 93,930,627 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B93,727,052 - 93,945,611 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B78,331,402 - 78,549,231 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B196,247,617 - 196,394,154 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B196,247,881 - 196,366,011 (-)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.1371,566,563 - 1,685,378 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl371,566,585 - 1,829,894 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha372,514,598 - 2,633,404 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0371,453,968 - 1,572,676 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl371,453,990 - 1,550,821 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1371,463,313 - 1,581,898 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0371,431,241 - 1,549,848 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0371,459,885 - 1,578,875 (-)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_024405303149,652,139 - 149,767,224 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365067,095,009 - 7,184,689 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365067,091,982 - 7,185,938 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl1595,656,077 - 95,763,472 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11595,656,206 - 95,764,099 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215106,914,582 - 106,960,243 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Sscrofa10.215107,069,138 - 107,073,997 (-)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.11076,553,626 - 76,708,540 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1076,553,606 - 76,674,928 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040122,773,405 - 122,923,766 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_0046248544,976,507 - 5,057,391 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248544,975,724 - 5,056,940 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Stat4
998 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:82
Count of miRNA genes:66
Interacting mature miRNAs:72
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10054125Srcrt7Stress Responsive Cort QTL 73.330.0011blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)9187073594Rat
1331757Cdexp1CD45RC expression in CD8 T cells QTL 14.3CD8-positive T cell quantity (VT:0008077)blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)9102453767509080Rat
631211Bw4Body weight QTL45.31retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)9510982650109826Rat
11353947Bp392Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)9728325252283252Rat
9589133Insul26Insulin level QTL 2617.960.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)9895256053952560Rat
7411609Foco16Food consumption QTL 1625.60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)9895256053952560Rat
631680Cm11Cardiac mass QTL 113.10.00089heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)92043051965430519Rat
70186Niddm26Non-insulin dependent diabetes mellitus QTL 263.87blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)92207116986369743Rat
631643Bp120Blood pressure QTL 12030.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)92207120067071200Rat
1598823Memor16Memory QTL 161.9exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)92213332249968732Rat
7207805Bmd88Bone mineral density QTL 884femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)92375402458157242Rat
1300180Bw14Body weight QTL 143.776body mass (VT:0001259)body weight (CMO:0000012)92375402461381613Rat
7207814Bmd91Bone mineral density QTL 913.5femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)92375414483851531Rat
70218Cm28Cardiac mass QTL 288.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)92526804479271759Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)925268044114175309Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)925661188100929786Rat
1641894Alcrsp12Alcohol response QTL 12response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)92746863972468639Rat
7411656Foco26Food consumption QTL 269.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)93253550577535505Rat
7411571Bw138Body weight QTL 13814.30.001body mass (VT:0001259)body weight gain (CMO:0000420)93253550577535505Rat
1598834Memor11Memory QTL 112.5exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)93696235977814038Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)93696235992058970Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)93696235995410867Rat
6903941Pur31Proteinuria QTL 310.036urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)94019418885194188Rat
11353949Bp393Blood pressure QTL 393arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94019418885194188Rat
61352Bp34Blood pressure QTL 345arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94249534379271511Rat
10058949Gmadr5Adrenal mass QTL 520.014adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)94279151387976209Rat
11353951Bp394Blood pressure QTL 394arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94464992189649921Rat
12879506Pur33Proteinuria QTL 33urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)94464992189649921Rat
11353957Bmd92Bone mineral density QTL 920.01tibia mineral mass (VT:1000283)volumetric bone mineral density (CMO:0001553)94611419991114199Rat
6903937Bp356Blood pressure QTL 3560.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94790220852283252Rat
631656Bp108Blood pressure QTL 1085.970.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94859825193598251Rat



RefSeq Acc Id: NM_001012226   ⟹   NP_001012226
Rat AssemblyChrPosition (strand)Source
GRCr8956,964,617 - 57,080,523 (-)NCBI
mRatBN7.2949,472,660 - 49,588,540 (-)NCBI
Rnor_6.0954,340,649 - 54,457,753 (-)NCBI
Rnor_5.0954,051,154 - 54,167,491 (-)NCBI
RGSC_v3.4946,510,251 - 46,650,076 (-)RGD
Celera947,135,713 - 47,243,684 (-)RGD
Protein Sequences
Protein RefSeqs NP_001012226 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC12758 (Get FASTA)   NCBI Sequence Viewer  
  AAH81938 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000019465.7
RefSeq Acc Id: NP_001012226   ⟸   NM_001012226
- UniProtKB: Q66HB2 (UniProtKB/TrEMBL),   F7FAC1 (UniProtKB/TrEMBL)
- Sequence:
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2JX93-F1-model_v2 AlphaFold A0A0G2JX93 1-1083 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1305747 AgrOrtholog
BioCyc Gene G2FUF-27606 BioCyc
Ensembl Genes ENSRNOG00000014079 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000019465.8 UniProtKB/TrEMBL
  ENSRNOT00000020032.7 UniProtKB/TrEMBL
  ENSRNOT00000080522.2 UniProtKB/TrEMBL
  ENSRNOT00000083514.2 UniProtKB/TrEMBL
Gene3D-CATH 1.10.532.10 UniProtKB/TrEMBL UniProtKB/TrEMBL
  3.30.505.10 UniProtKB/TrEMBL UniProtKB/TrEMBL
  EF-hand UniProtKB/TrEMBL
  STAT transcription factor, all-alpha domain UniProtKB/TrEMBL
InterPro p53-like_TF_DNA-bd UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SH2_dom_sf UniProtKB/TrEMBL
  STAT1_C_sf UniProtKB/TrEMBL
  STAT1_TAZ2-bd_C UniProtKB/TrEMBL
  STAT_linker UniProtKB/TrEMBL
  STAT_N_sf UniProtKB/TrEMBL
  STAT_TF_alpha UniProtKB/TrEMBL
  STAT_TF_coiled-coil UniProtKB/TrEMBL
  STAT_TF_core UniProtKB/TrEMBL
  STAT_TF_DNA-bd_sub UniProtKB/TrEMBL
  STAT_TF_prot_interaction UniProtKB/TrEMBL
KEGG Report rno:367264 UniProtKB/TrEMBL
Pfam SH2 UniProtKB/TrEMBL
  STAT1_TAZ2bind UniProtKB/TrEMBL
  STAT_alpha UniProtKB/TrEMBL
  STAT_bind UniProtKB/TrEMBL
  STAT_int UniProtKB/TrEMBL
  STAT_linker UniProtKB/TrEMBL
PhenoGen Stat4 PhenoGen
RatGTEx ENSRNOG00000014079 RatGTEx
Superfamily-SCOP P53_like_DNA_bnd UniProtKB/TrEMBL
  SSF55550 UniProtKB/TrEMBL
UniProt A0A0G2JX93_RAT UniProtKB/TrEMBL
  O70428_RAT UniProtKB/TrEMBL

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-12-06 Stat4  signal transducer and activator of transcription 4  Stat4_predicted  signal transducer and activator of transcription 4 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Stat4_predicted  signal transducer and activator of transcription 4 (predicted)      Symbol and Name status set to approved 70820 APPROVED