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Gene: Cybrd1 (cytochrome b reductase 1) Rattus norvegicus

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Symbol:

Cybrd1

Name:

cytochrome b reductase 1

RGD ID:

1305740

Description:

Predicted to enable identical protein binding activity; transmembrane ascorbate ferrireductase activity; and transmembrane monodehydroascorbate reductase activity. Predicted to be involved in ascorbate homeostasis; intracellular iron ion homeostasis; and multicellular organismal-level iron ion homeostasis. Predicted to act upstream of or within response to iron ion. Predicted to be located in apical plasma membrane and brush border membrane. Predicted to be active in lysosomal membrane. Orthologous to human CYBRD1 (cytochrome b reductase 1); PARTICIPATES IN iron uptake pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4',5-pentachlorobiphenyl; 6-propyl-2-thiouracil.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

Dcytb; duodenal cytochrome b; LOC295669; plasma membrane ascorbate-dependent reductase CYBRD1

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	CYBRD1 (cytochrome b reductase 1)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Cybrd1 (cytochrome b reductase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	LOC102019452 (cytochrome b reductase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	LOC100972759 (plasma membrane ascorbate-dependent reductase CYBRD1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	CYBRD1 (cytochrome b reductase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	LOC101976046 (cytochrome b reductase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	CYBRD1 (cytochrome b reductase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	CYBRD1 (cytochrome b reductase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	LOC101701182 (cytochrome b reductase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	ZEB1 (zinc finger E-box binding homeobox 1)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	CYBRD1 (cytochrome b reductase 1)	Alliance	DIOPT (HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Cybrd1 (cytochrome b reductase 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	cybrd1 (cytochrome b reductase 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG1275	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|OrthoFinder\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	F55H2.5	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|OrthoInspector\|PANTHER)
Xenopus tropicalis (tropical clawed frog):	cybrd1	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	76,342,231 - 76,369,846 (+)	NCBI		GRCr8
mRatBN7.2	3	55,934,874 - 55,962,132 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	55,934,874 - 55,962,108 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	59,332,726 - 59,359,977 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	67,916,303 - 67,943,578 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	65,678,375 - 65,705,591 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	57,718,496 - 57,745,749 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	57,718,364 - 57,746,097 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	64,212,933 - 64,240,184 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	53,381,122 - 53,408,375 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	3	53,277,493 - 53,304,724 (+)	NCBI
Celera	3	55,482,564 - 55,509,842 (+)	NCBI		Celera
Cytogenetic Map	3	q22	NCBI

JBrowse:

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Model

Annotation Click to see Annotation Detail View

RGD Manual Disease Annotations Click to see Annotation Detail View

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Cybrd1	Rat	COVID-19		ISO	RGD:1313951	9068941	mRNA:increased expression:peripheral blood mononuclear cell (human)	RGD	PMID:32228226\|REF_RGD_ID:28912744

Imported Disease Annotations - ClinVar

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Cybrd1	Rat	split hand-foot malformation 5		ISO	RGD:1313951	8554872	ClinVar Annotator: match by term: Split hand-foot malformation 5	ClinVar	PMID:25741868

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Cybrd1	Rat	1,1-dichloroethene	increases expression	ISO	RGD:1313952	6480464	vinylidene chloride results in increased expression of CYBRD1 mRNA	CTD	PMID:26682919
Cybrd1	Rat	1,2-dimethylhydrazine	decreases expression	ISO	RGD:1313952	6480464	1,2-Dimethylhydrazine results in decreased expression of CYBRD1 mRNA	CTD	PMID:22206623
Cybrd1	Rat	2,3,7,8-tetrachlorodibenzodioxine	decreases expression	ISO	RGD:1313951	6480464	Tetrachlorodibenzodioxin results in decreased expression of CYBRD1 mRNA	CTD	PMID:17101203
Cybrd1	Rat	2,3,7,8-tetrachlorodibenzodioxine	decreases expression	EXP		6480464	Tetrachlorodibenzodioxin results in decreased expression of CYBRD1 mRNA	CTD	PMID:33387578
Cybrd1	Rat	2,3,7,8-tetrachlorodibenzodioxine	decreases expression	ISO	RGD:1313952	6480464	Tetrachlorodibenzodioxin results in decreased expression of CYBRD1 mRNA	CTD	PMID:28213091
Cybrd1	Rat	2,3,7,8-tetrachlorodibenzodioxine	affects expression	ISO	RGD:1313951	6480464	Tetrachlorodibenzodioxin affects the expression of CYBRD1 mRNA	CTD	PMID:22298810
Cybrd1	Rat	3,3',4,4',5-pentachlorobiphenyl	decreases expression	EXP		6480464	3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of CYBRD1 mRNA	CTD	PMID:23196670
Cybrd1	Rat	4,4'-sulfonyldiphenol	decreases methylation	ISO	RGD:1313952	6480464	bisphenol S results in decreased methylation of CYBRD1 exon	CTD	PMID:33297965
Cybrd1	Rat	4,4'-sulfonyldiphenol	increases expression	ISO	RGD:1313951	6480464	bisphenol S results in increased expression of CYBRD1 protein	CTD	PMID:34186270
Cybrd1	Rat	6-propyl-2-thiouracil	increases expression	EXP		6480464	Propylthiouracil results in increased expression of CYBRD1 mRNA	CTD	PMID:24780913
Cybrd1	Rat	aflatoxin B1	decreases methylation	ISO	RGD:1313951	6480464	Aflatoxin B1 results in decreased methylation of CYBRD1 intron	CTD	PMID:30157460
Cybrd1	Rat	Aflatoxin B2 alpha	decreases methylation	ISO	RGD:1313951	6480464	aflatoxin B2 results in decreased methylation of CYBRD1 intron	CTD	PMID:30157460
Cybrd1	Rat	arsenous acid	increases expression	ISO	RGD:1313951	6480464	Arsenic Trioxide results in increased expression of CYBRD1 mRNA	CTD	PMID:15761015
Cybrd1	Rat	atrazine	increases expression	ISO	RGD:1313951	6480464	Atrazine results in increased expression of CYBRD1 mRNA	CTD	PMID:22378314
Cybrd1	Rat	atrazine	affects methylation	EXP		6480464	Atrazine affects the methylation of CYBRD1 gene	CTD	PMID:35440735
Cybrd1	Rat	bisphenol A	increases expression	EXP		6480464	bisphenol A results in increased expression of CYBRD1 mRNA	CTD	PMID:25181051
Cybrd1	Rat	bisphenol A	increases expression	ISO	RGD:1313952	6480464	bisphenol A results in increased expression of CYBRD1 mRNA	CTD	PMID:32156529
Cybrd1	Rat	bisphenol A	decreases methylation	ISO	RGD:1313951	6480464	bisphenol A results in decreased methylation of CYBRD1 gene	CTD	PMID:31601247
Cybrd1	Rat	bisphenol A	decreases expression	EXP		6480464	bisphenol A results in decreased expression of CYBRD1 mRNA	CTD	PMID:34947998
Cybrd1	Rat	bisphenol A	increases expression	ISO	RGD:1313951	6480464	bisphenol A results in increased expression of CYBRD1 mRNA; bisphenol A results in increased expression more ...	CTD	PMID:29275510\|PMID:34186270
Cybrd1	Rat	bisphenol AF	increases expression	ISO	RGD:1313951	6480464	bisphenol AF results in increased expression of CYBRD1 protein	CTD	PMID:34186270
Cybrd1	Rat	Bisphenol B	increases expression	ISO	RGD:1313951	6480464	bisphenol B results in increased expression of CYBRD1 protein	CTD	PMID:34186270
Cybrd1	Rat	butan-1-ol	multiple interactions	ISO	RGD:1313951	6480464	[[Gasoline co-treated with 1-Butanol] results in increased abundance of [Particulate Matter co-treated with Polycyclic Aromatic more ...	CTD	PMID:29432896
Cybrd1	Rat	cadmium atom	multiple interactions	ISO	RGD:1313952	6480464	[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of CYBRD1 more ...	CTD	PMID:32645461
Cybrd1	Rat	cadmium atom	increases expression	EXP		6480464	Cadmium results in increased expression of CYBRD1 mRNA	CTD	PMID:39025289
Cybrd1	Rat	cadmium atom	multiple interactions	ISO	RGD:1313951	6480464	[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of CYBRD1 more ...	CTD	PMID:32645461
Cybrd1	Rat	cadmium dichloride	multiple interactions	ISO	RGD:1313951	6480464	[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of CYBRD1 more ...	CTD	PMID:32645461
Cybrd1	Rat	cadmium dichloride	multiple interactions	ISO	RGD:1313952	6480464	[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of CYBRD1 more ...	CTD	PMID:32645461
Cybrd1	Rat	carbon nanotube	decreases expression	ISO	RGD:1313952	6480464	Nanotubes, Carbon analog results in decreased expression of CYBRD1 mRNA; Nanotubes, Carbon results in decreased more ...	CTD	PMID:25554681
Cybrd1	Rat	CGP 52608	multiple interactions	ISO	RGD:1313951	6480464	CGP 52608 promotes the reaction [RORA protein binds to CYBRD1 gene]	CTD	PMID:28238834
Cybrd1	Rat	chromium(6+)	decreases expression	ISO	RGD:1313952	6480464	chromium hexavalent ion results in decreased expression of CYBRD1 mRNA	CTD	PMID:24418189
Cybrd1	Rat	chromium(6+)	decreases expression	EXP		6480464	chromium hexavalent ion results in decreased expression of CYBRD1 mRNA	CTD	PMID:24418189
Cybrd1	Rat	cisplatin	increases expression	ISO	RGD:1313951	6480464	Cisplatin results in increased expression of CYBRD1 mRNA	CTD	PMID:27594783
Cybrd1	Rat	cisplatin	multiple interactions	ISO	RGD:1313951	6480464	[Cisplatin co-treated with jinfukang] results in increased expression of CYBRD1 mRNA	CTD	PMID:27392435
Cybrd1	Rat	cobalt dichloride	increases expression	EXP		6480464	cobaltous chloride results in increased expression of CYBRD1 mRNA	CTD	PMID:23814049
Cybrd1	Rat	cobalt dichloride	multiple interactions	EXP		6480464	Plicamycin inhibits the reaction [cobaltous chloride results in increased expression of CYBRD1 mRNA]	CTD	PMID:23814049
Cybrd1	Rat	copper atom	increases expression	EXP		6480464	Copper deficiency results in increased expression of CYBRD1 mRNA	CTD	PMID:19821111
Cybrd1	Rat	copper atom	increases expression	ISO	RGD:1313952	6480464	Copper deficiency results in increased expression of CYBRD1 mRNA; Copper deficiency results in increased expression more ...	CTD	PMID:23555700
Cybrd1	Rat	copper atom	multiple interactions	ISO	RGD:1313952	6480464	EPAS1 gene mutant form inhibits the reaction [Copper deficiency results in increased expression of CYBRD1 more ...	CTD	PMID:23555700
Cybrd1	Rat	copper(0)	increases expression	EXP		6480464	Copper deficiency results in increased expression of CYBRD1 mRNA	CTD	PMID:19821111
Cybrd1	Rat	copper(0)	multiple interactions	ISO	RGD:1313952	6480464	EPAS1 gene mutant form inhibits the reaction [Copper deficiency results in increased expression of CYBRD1 more ...	CTD	PMID:23555700
Cybrd1	Rat	copper(0)	increases expression	ISO	RGD:1313952	6480464	Copper deficiency results in increased expression of CYBRD1 mRNA; Copper deficiency results in increased expression more ...	CTD	PMID:23555700
Cybrd1	Rat	copper(II) chloride	decreases expression	ISO	RGD:1313951	6480464	cupric chloride results in decreased expression of CYBRD1 mRNA	CTD	PMID:38568856
Cybrd1	Rat	Cuprizon	increases expression	EXP		6480464	Cuprizone results in increased expression of CYBRD1 mRNA	CTD	PMID:26577399
Cybrd1	Rat	Cuprizon	decreases expression	EXP		6480464	Cuprizone results in decreased expression of CYBRD1 mRNA	CTD	PMID:27523638
Cybrd1	Rat	daidzein	multiple interactions	ISO	RGD:1313951	6480464	[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with more ...	CTD	PMID:27424125
Cybrd1	Rat	daidzein 7-O-beta-D-glucoside	multiple interactions	ISO	RGD:1313951	6480464	[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with more ...	CTD	PMID:27424125
Cybrd1	Rat	diallyl trisulfide	increases expression	EXP		6480464	diallyl trisulfide results in increased expression of CYBRD1 mRNA	CTD	PMID:34014027
Cybrd1	Rat	diarsenic trioxide	increases expression	ISO	RGD:1313951	6480464	Arsenic Trioxide results in increased expression of CYBRD1 mRNA	CTD	PMID:15761015
Cybrd1	Rat	dibutyl phthalate	increases expression	ISO	RGD:1313952	6480464	Dibutyl Phthalate results in increased expression of CYBRD1 mRNA	CTD	PMID:21266533
Cybrd1	Rat	dimethylarsinic acid	decreases expression	EXP		6480464	Cacodylic Acid results in decreased expression of CYBRD1 mRNA	CTD	PMID:37567419
Cybrd1	Rat	dioxygen	affects methylation	ISO	RGD:1313952	6480464	Oxygen deficiency affects the methylation of CYBRD1 promoter	CTD	PMID:24205000
Cybrd1	Rat	dioxygen	multiple interactions	ISO	RGD:1313952	6480464	[NFE2L2 protein affects the susceptibility to Oxygen] which affects the expression of CYBRD1 mRNA	CTD	PMID:30529165
Cybrd1	Rat	dioxygen	increases expression	ISO	RGD:1313952	6480464	Oxygen deficiency results in increased expression of CYBRD1 mRNA	CTD	PMID:24205000
Cybrd1	Rat	dorsomorphin	multiple interactions	ISO	RGD:1313951	6480464	[NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased more ...	CTD	PMID:27188386
Cybrd1	Rat	doxorubicin	affects expression	ISO	RGD:1313951	6480464	Doxorubicin affects the expression of CYBRD1 mRNA	CTD	PMID:29803840
Cybrd1	Rat	entinostat	increases expression	ISO	RGD:1313951	6480464	entinostat results in increased expression of CYBRD1 mRNA	CTD	PMID:27188386
Cybrd1	Rat	ethanol	multiple interactions	ISO	RGD:1313951	6480464	[[Gasoline co-treated with Ethanol] results in increased abundance of [Particulate Matter co-treated with Polycyclic Aromatic more ...	CTD	PMID:29432896
Cybrd1	Rat	ethanol	increases expression	ISO	RGD:1313952	6480464	Ethanol results in increased expression of CYBRD1 mRNA	CTD	PMID:30319688
Cybrd1	Rat	ethanol	affects expression	ISO	RGD:1313952	6480464	Ethanol affects the expression of CYBRD1 mRNA	CTD	PMID:30319688
Cybrd1	Rat	genistein	multiple interactions	ISO	RGD:1313951	6480464	[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with more ...	CTD	PMID:27424125
Cybrd1	Rat	genistein	increases expression	ISO	RGD:1313952	6480464	Genistein results in increased expression of CYBRD1 mRNA	CTD	PMID:32186404
Cybrd1	Rat	genistein 7-O-beta-D-glucoside	multiple interactions	ISO	RGD:1313951	6480464	[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with more ...	CTD	PMID:27424125
Cybrd1	Rat	gentamycin	decreases expression	EXP		6480464	Gentamicins results in decreased expression of CYBRD1 mRNA	CTD	PMID:33387578
Cybrd1	Rat	glycitein	multiple interactions	ISO	RGD:1313951	6480464	[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with more ...	CTD	PMID:27424125
Cybrd1	Rat	glycitin	multiple interactions	ISO	RGD:1313951	6480464	[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with more ...	CTD	PMID:27424125
Cybrd1	Rat	iron atom	decreases expression	ISO	RGD:1313951	6480464	Iron results in decreased expression of CYBRD1 protein	CTD	PMID:18815723
Cybrd1	Rat	iron atom	increases expression	EXP		6480464	Iron deficiency results in increased expression of CYBRD1 mRNA	CTD	PMID:16629162\|PMID:19821111\|PMID:21540277\|PMID:23814049
Cybrd1	Rat	iron atom	increases expression	ISO	RGD:1313952	6480464	Iron deficiency results in increased expression of CYBRD1 mRNA	CTD	PMID:23776592
Cybrd1	Rat	iron atom	increases expression	ISO	RGD:1313951	6480464	Iron results in increased expression of CYBRD1 protein	CTD	PMID:18815723
Cybrd1	Rat	iron(0)	increases expression	ISO	RGD:1313952	6480464	Iron deficiency results in increased expression of CYBRD1 mRNA	CTD	PMID:23776592
Cybrd1	Rat	iron(0)	increases expression	EXP		6480464	Iron deficiency results in increased expression of CYBRD1 mRNA	CTD	PMID:16629162\|PMID:19821111\|PMID:21540277\|PMID:23814049
Cybrd1	Rat	iron(0)	increases expression	ISO	RGD:1313951	6480464	Iron results in increased expression of CYBRD1 protein	CTD	PMID:18815723
Cybrd1	Rat	iron(0)	decreases expression	ISO	RGD:1313951	6480464	Iron results in decreased expression of CYBRD1 protein	CTD	PMID:18815723
Cybrd1	Rat	L-ascorbic acid	decreases expression	ISO	RGD:1313951	6480464	Ascorbic Acid results in decreased expression of CYBRD1 protein	CTD	PMID:18815723
Cybrd1	Rat	L-ascorbic acid	increases expression	ISO	RGD:1313951	6480464	Ascorbic Acid results in increased expression of CYBRD1 protein	CTD	PMID:18815723
Cybrd1	Rat	mithramycin	multiple interactions	EXP		6480464	Plicamycin inhibits the reaction [cobaltous chloride results in increased expression of CYBRD1 mRNA]	CTD	PMID:23814049
Cybrd1	Rat	mithramycin	decreases expression	EXP		6480464	Plicamycin results in decreased expression of CYBRD1 mRNA	CTD	PMID:23814049
Cybrd1	Rat	nickel atom	decreases expression	ISO	RGD:1313951	6480464	Nickel results in decreased expression of CYBRD1 mRNA	CTD	PMID:23195993\|PMID:24768652\|PMID:25583101
Cybrd1	Rat	okadaic acid	decreases expression	ISO	RGD:1313951	6480464	Okadaic Acid results in decreased expression of CYBRD1 mRNA	CTD	PMID:38832940
Cybrd1	Rat	oxybenzone	increases expression	EXP		6480464	oxybenzone results in increased expression of CYBRD1 mRNA	CTD	PMID:30316929
Cybrd1	Rat	ozone	multiple interactions	ISO	RGD:1313952	6480464	[Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which results in decreased more ...	CTD	PMID:34911549
Cybrd1	Rat	paracetamol	decreases expression	EXP		6480464	Acetaminophen results in decreased expression of CYBRD1 mRNA	CTD	PMID:33387578
Cybrd1	Rat	paraquat	decreases expression	EXP		6480464	Paraquat results in decreased expression of CYBRD1 mRNA	CTD	PMID:32680482
Cybrd1	Rat	phenylmercury acetate	increases expression	ISO	RGD:1313951	6480464	Phenylmercuric Acetate results in increased expression of CYBRD1 mRNA	CTD	PMID:26272509
Cybrd1	Rat	phenylmercury acetate	multiple interactions	ISO	RGD:1313951	6480464	[NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased more ...	CTD	PMID:27188386
Cybrd1	Rat	SB 431542	multiple interactions	ISO	RGD:1313951	6480464	[NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased more ...	CTD	PMID:27188386
Cybrd1	Rat	sodium arsenite	decreases expression	ISO	RGD:1313951	6480464	sodium arsenite results in decreased expression of CYBRD1 mRNA	CTD	PMID:34032870\|PMID:38568856
Cybrd1	Rat	sodium dichromate	decreases expression	EXP		6480464	sodium bichromate results in decreased expression of CYBRD1 mRNA	CTD	PMID:22561333
Cybrd1	Rat	sodium dichromate	increases expression	ISO	RGD:1313952	6480464	sodium bichromate results in increased expression of CYBRD1 mRNA	CTD	PMID:22155349
Cybrd1	Rat	sunitinib	increases expression	ISO	RGD:1313951	6480464	Sunitinib results in increased expression of CYBRD1 mRNA	CTD	PMID:31533062
Cybrd1	Rat	temozolomide	decreases expression	ISO	RGD:1313951	6480464	Temozolomide results in decreased expression of CYBRD1 mRNA	CTD	PMID:31758290
Cybrd1	Rat	thiram	decreases expression	ISO	RGD:1313951	6480464	Thiram results in decreased expression of CYBRD1 mRNA	CTD	PMID:38568856
Cybrd1	Rat	titanium dioxide	decreases expression	ISO	RGD:1313952	6480464	titanium dioxide results in decreased expression of CYBRD1 mRNA	CTD	PMID:27760801
Cybrd1	Rat	titanium dioxide	decreases methylation	ISO	RGD:1313952	6480464	titanium dioxide results in decreased methylation of CYBRD1 gene	CTD	PMID:35295148
Cybrd1	Rat	trichostatin A	decreases expression	ISO	RGD:1313951	6480464	trichostatin A results in decreased expression of CYBRD1 mRNA	CTD	PMID:24935251
Cybrd1	Rat	triphenyl phosphate	affects expression	ISO	RGD:1313951	6480464	triphenyl phosphate affects the expression of CYBRD1 mRNA	CTD	PMID:37042841
Cybrd1	Rat	triptonide	increases expression	ISO	RGD:1313952	6480464	triptonide results in increased expression of CYBRD1 mRNA	CTD	PMID:33045310
Cybrd1	Rat	valproic acid	affects expression	ISO	RGD:1313951	6480464	Valproic Acid affects the expression of CYBRD1 mRNA	CTD	PMID:25979313
Cybrd1	Rat	valproic acid	increases expression	ISO	RGD:1313951	6480464	Valproic Acid results in increased expression of CYBRD1 mRNA	CTD	PMID:23179753\|PMID:26272509\|PMID:27188386
Cybrd1	Rat	valproic acid	multiple interactions	ISO	RGD:1313951	6480464	[NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased more ...	CTD	PMID:27188386
Cybrd1	Rat	valproic acid	increases expression	ISO	RGD:1313952	6480464	Valproic Acid results in increased expression of CYBRD1 mRNA	CTD	PMID:24896083
Cybrd1	Rat	valproic acid	decreases expression	ISO	RGD:1313951	6480464	Valproic Acid results in decreased expression of CYBRD1 mRNA	CTD	PMID:23179753\|PMID:24935251\|PMID:28001369
Cybrd1	Rat	vinclozolin	affects expression	EXP		6480464	vinclozolin affects the expression of CYBRD1 mRNA	CTD	PMID:19015723
Cybrd1	Rat	vinclozolin	increases expression	EXP		6480464	vinclozolin results in increased expression of CYBRD1 mRNA	CTD	PMID:23034163

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Cybrd1	Rat	ascorbate homeostasis	involved_in	ISS	UniProtKB:Q53TN4	1600115	GO_REF:0000024	UniProt	GO_REF:0000024
Cybrd1	Rat	ascorbate homeostasis	involved_in	IEA	UniProtKB:Q53TN4\|ensembl:ENSP00000319141	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Cybrd1	Rat	ascorbate homeostasis	involved_in	ISO	RGD:1313951	1624291	PMID:17068337	RGD	PMID:17068337
Cybrd1	Rat	intracellular iron ion homeostasis	involved_in	ISO	RGD:1313951	1624291	PMID:14499595	RGD	PMID:14499595
Cybrd1	Rat	intracellular iron ion homeostasis	involved_in	IEA	UniProtKB:Q53TN4\|ensembl:ENSP00000319141	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Cybrd1	Rat	multicellular organismal-level iron ion homeostasis	involved_in	ISS	UniProtKB:Q53TN4	1600115	GO_REF:0000024	UniProt	GO_REF:0000024
Cybrd1	Rat	multicellular organismal-level iron ion homeostasis	involved_in	IEA	UniProtKB:Q53TN4\|ensembl:ENSP00000319141	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Cybrd1	Rat	multicellular organismal-level iron ion homeostasis	involved_in	ISO	RGD:1313951	1624291	PMID:30272000	RGD	PMID:30272000
Cybrd1	Rat	response to iron ion	acts_upstream_of_or_within	IEA	UniProtKB:Q925G2\|ensembl:ENSMUSP00000028403	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Cybrd1	Rat	response to iron ion	acts_upstream_of_or_within	ISO	RGD:1313952	1624291	PMID:11230685	RGD	PMID:11230685
Cybrd1	Rat	transmembrane transport	involved_in	IEA	GO:0140571	1600115	GO_REF:0000108	GOC	GO_REF:0000108

Cellular Component

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Cybrd1	Rat	apical plasma membrane	located_in	ISS	UniProtKB:Q53TN4	1600115	GO_REF:0000024	UniProt	GO_REF:0000024
Cybrd1	Rat	apical plasma membrane	located_in	IEA	UniProtKB:Q53TN4\|ensembl:ENSP00000319141	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Cybrd1	Rat	apical plasma membrane	located_in	IEA	UniProtKB-SubCell:SL-0015	1600115	GO_REF:0000044	UniProt	GO_REF:0000044
Cybrd1	Rat	apical plasma membrane	located_in	ISO	RGD:1313951	1624291	PMID:12949720	RGD	PMID:12949720
Cybrd1	Rat	brush border membrane	located_in	ISS	UniProtKB:Q53TN4	1600115	GO_REF:0000024	UniProt	GO_REF:0000024
Cybrd1	Rat	brush border membrane	located_in	IEA	UniProtKB:Q925G2\|ensembl:ENSMUSP00000028403	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Cybrd1	Rat	brush border membrane	located_in	IEA	UniProtKB:Q53TN4\|ensembl:ENSP00000319141	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Cybrd1	Rat	brush border membrane	located_in	ISO	RGD:1313952	1624291	PMID:11230685	RGD	PMID:11230685
Cybrd1	Rat	brush border membrane	located_in	ISO	RGD:1313951	1624291	PMID:12949720	RGD	PMID:12949720
Cybrd1	Rat	lysosomal membrane	is_active_in	IBA	MGI:2686925\|PANTHER:PTN001297406	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Cybrd1	Rat	membrane	located_in	ISO	RGD:1313951	1624291	PMID:30272000	RGD	PMID:30272000
Cybrd1	Rat	membrane	located_in	IEA	UniProtKB-KW:KW-0472	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Cybrd1	Rat	membrane	located_in	IEA	UniProtKB:Q53TN4\|ensembl:ENSP00000319141	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Cybrd1	Rat	membrane	located_in	ISS	UniProtKB:Q53TN4	1600115	GO_REF:0000024	UniProt	GO_REF:0000024
Cybrd1	Rat	plasma membrane	located_in	ISO	RGD:1313951	1624291	PMID:17068337	RGD	PMID:17068337
Cybrd1	Rat	plasma membrane	located_in	IEA	UniProtKB-SubCell:SL-0039	1600115	GO_REF:0000044	UniProt	GO_REF:0000044
Cybrd1	Rat	plasma membrane	located_in	IEA	UniProtKB-KW:KW-1003	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Cybrd1	Rat	plasma membrane	located_in	IEA	UniProtKB:Q53TN4\|ensembl:ENSP00000319141	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Cybrd1	Rat	plasma membrane	located_in	ISO	RGD:1313951\|UniProtKB:Q53TN4-1\|UniProtKB:Q53TN4-3	1624291		RGD	GO_REF:0000052

Molecular Function

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Cybrd1	Rat	identical protein binding	enables	ISS	UniProtKB:Q53TN4	1600115	GO_REF:0000024	UniProt	GO_REF:0000024
Cybrd1	Rat	identical protein binding	enables	IEA	UniProtKB:Q53TN4\|ensembl:ENSP00000319141	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Cybrd1	Rat	identical protein binding	enables	ISO	RGD:1313951	1624291	PMID:30272000	RGD	PMID:30272000
Cybrd1	Rat	metal ion binding	enables	IEA	UniProtKB-KW:KW-0479	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Cybrd1	Rat	oxidoreductase activity	enables	IEA	UniProtKB-KW:KW-0560	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Cybrd1	Rat	oxidoreductase activity	enables	IEA	InterPro:IPR043205	1600115	GO_REF:0000002	InterPro	GO_REF:0000002
Cybrd1	Rat	oxidoreductase activity	enables	IBA	MGI:103253\|MGI:2654575\|MGI:2686925\|PANTHER:PTN000010357\|TAIR:locus:2131859\|TAIR:locus:2159858\|UniProtKB:P10897\|UniProtKB:Q53TN4	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Cybrd1	Rat	oxidoreductase activity, acting on metal ions	enables	ISO	RGD:1313951	1624291	PMID:14499595	RGD	PMID:14499595
Cybrd1	Rat	oxidoreductase activity, acting on metal ions	enables	IEA	UniProtKB:Q53TN4\|ensembl:ENSP00000319141	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Cybrd1	Rat	protein binding	enables	ISO	RGD:1313951	1624291	UniProtKB:O14653\|UniProtKB:O15400\|UniProtKB:O75400-2\|UniProtKB:O95159\|UniProtKB:O95292\|UniProtKB:P09601\|UniProtKB:P13473-2\|UniProtKB:P55212\|UniProtKB:Q04941\|UniProtKB:Q12846\|UniProtKB:Q14318\|UniProtKB:Q6PI78\|UniProtKB:Q8N6R1\|UniProtKB:Q96F15\|UniProtKB:Q96IW7\|UniProtKB:Q9BXJ8\|UniProtKB:Q9P0L0\|UniProtKB:Q9UBY5\|UniProtKB:Q9UI14\|UniProtKB:Q9Y371\|UniProtKB:Q9Y6X1 PMID:21516116, PMID:25416956, PMID:25910212, PMID:32296183, PMID:32814053	RGD	PMID:21516116\|PMID:25416956\|PMID:25910212\|PMID:32296183\|PMID:32814053
Cybrd1	Rat	transmembrane ascorbate ferrireductase activity	enables	ISS	UniProtKB:Q53TN4	1600115	GO_REF:0000024	UniProt	GO_REF:0000024
Cybrd1	Rat	transmembrane ascorbate ferrireductase activity	enables	IEA	EC:7.2.1.3	1600115	GO_REF:0000003	UniProt	GO_REF:0000003
Cybrd1	Rat	transmembrane ascorbate ferrireductase activity	enables	IEA	RHEA:30403	1600115	GO_REF:0000116	RHEA	GO_REF:0000116
Cybrd1	Rat	transmembrane ascorbate ferrireductase activity	enables	IEA	UniProtKB:Q925G2\|ensembl:ENSMUSP00000028403	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Cybrd1	Rat	transmembrane ascorbate ferrireductase activity	enables	IEA	UniProtKB:Q53TN4\|ensembl:ENSP00000319141	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Cybrd1	Rat	transmembrane ascorbate ferrireductase activity	enables	ISO	RGD:1313952	1624291	PMID:17068337	RGD	PMID:17068337
Cybrd1	Rat	transmembrane ascorbate ferrireductase activity	enables	ISO	RGD:1313951	1624291	PMID:17068337, PMID:30272000	RGD	PMID:17068337\|PMID:30272000
Cybrd1	Rat	transmembrane monodehydroascorbate reductase activity	enables	ISS	UniProtKB:Q53TN4	1600115	GO_REF:0000024	UniProt	GO_REF:0000024
Cybrd1	Rat	transmembrane monodehydroascorbate reductase activity	enables	IEA	UniProtKB:Q53TN4\|ensembl:ENSP00000319141	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Cybrd1	Rat	transmembrane monodehydroascorbate reductase activity	enables	IEA	RHEA:66524	1600115	GO_REF:0000116	RHEA	GO_REF:0000116
Cybrd1	Rat	transmembrane monodehydroascorbate reductase activity	enables	ISO	RGD:1313951	1624291	PMID:17068337	RGD	PMID:17068337

Molecular Pathway Annotations Click to see Annotation Detail View

RGD Manual Annotations

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Cybrd1	Rat	iron uptake pathway		ISO	RGD:1313951	11554199		RGD

Disease Annotations Click to see Annotation Detail View

COVID-19 (ISO)

split hand-foot malformation 5 (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,1-dichloroethene (ISO)

1,2-dimethylhydrazine (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

3,3',4,4',5-pentachlorobiphenyl (EXP)

4,4'-sulfonyldiphenol (ISO)

6-propyl-2-thiouracil (EXP)

aflatoxin B1 (ISO)

Aflatoxin B2 alpha (ISO)

arsenous acid (ISO)

atrazine (EXP,ISO)

bisphenol A (EXP,ISO)

bisphenol AF (ISO)

Bisphenol B (ISO)

butan-1-ol (ISO)

cadmium atom (EXP,ISO)

cadmium dichloride (ISO)

carbon nanotube (ISO)

CGP 52608 (ISO)

chromium(6+) (EXP,ISO)

cisplatin (ISO)

cobalt dichloride (EXP)

copper atom (EXP,ISO)

copper(0) (EXP,ISO)

copper(II) chloride (ISO)

Cuprizon (EXP)

daidzein (ISO)

daidzein 7-O-beta-D-glucoside (ISO)

diallyl trisulfide (EXP)

diarsenic trioxide (ISO)

dibutyl phthalate (ISO)

dimethylarsinic acid (EXP)

dioxygen (ISO)

dorsomorphin (ISO)

doxorubicin (ISO)

entinostat (ISO)

ethanol (ISO)

genistein (ISO)

genistein 7-O-beta-D-glucoside (ISO)

gentamycin (EXP)

glycitein (ISO)

glycitin (ISO)

iron atom (EXP,ISO)

iron(0) (EXP,ISO)

L-ascorbic acid (ISO)

mithramycin (EXP)

nickel atom (ISO)

okadaic acid (ISO)

oxybenzone (EXP)

ozone (ISO)

paracetamol (EXP)

paraquat (EXP)

phenylmercury acetate (ISO)

SB 431542 (ISO)

sodium arsenite (ISO)

sodium dichromate (EXP,ISO)

sunitinib (ISO)

temozolomide (ISO)

thiram (ISO)

titanium dioxide (ISO)

trichostatin A (ISO)

triphenyl phosphate (ISO)

triptonide (ISO)

valproic acid (ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

ascorbate homeostasis (IEA,ISO,ISS)

intracellular iron ion homeostasis (IEA,ISO)

multicellular organismal-level iron ion homeostasis (IEA,ISO,ISS)

response to iron ion (IEA,ISO)

transmembrane transport (IEA)

Cellular Component

apical plasma membrane (IEA,ISO,ISS)

brush border membrane (IEA,ISO,ISS)

lysosomal membrane (IBA)

membrane (IEA,ISO,ISS)

plasma membrane (IEA,ISO)

Molecular Function

identical protein binding (IEA,ISO,ISS)

metal ion binding (IEA)

oxidoreductase activity (IBA,IEA)

oxidoreductase activity, acting on metal ions (IEA,ISO)

protein binding (ISO)

transmembrane ascorbate ferrireductase activity (IEA,ISO,ISS)

transmembrane monodehydroascorbate reductase activity (IEA,ISO,ISS)

Molecular Pathway Annotations Click to see Annotation Detail View

iron uptake pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Cellular iron uptake, trafficking and metabolism: Key molecules and mechanisms and their roles in disease.	Lane DJ, etal., Biochim Biophys Acta. 2015 May;1853(5):1130-44. doi: 10.1016/j.bbamcr.2015.01.021. Epub 2015 Feb 4.
3.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
4.	GOA pipeline	RGD automated data pipeline
5.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:11230685	PMID:12477932	PMID:14499595	PMID:16510471	PMID:19056867	PMID:23447582	PMID:23597830	PMID:25745840

Genomics

Comparative Map Data

Cybrd1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	76,342,231 - 76,369,846 (+)	NCBI		GRCr8
mRatBN7.2	3	55,934,874 - 55,962,132 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	55,934,874 - 55,962,108 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	59,332,726 - 59,359,977 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	67,916,303 - 67,943,578 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	65,678,375 - 65,705,591 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	57,718,496 - 57,745,749 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	57,718,364 - 57,746,097 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	64,212,933 - 64,240,184 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	53,381,122 - 53,408,375 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	3	53,277,493 - 53,304,724 (+)	NCBI
Celera	3	55,482,564 - 55,509,842 (+)	NCBI		Celera
Cytogenetic Map	3	q22	NCBI

CYBRD1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	2	171,522,233 - 171,558,129 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	2	171,522,247 - 171,558,129 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	2	172,378,743 - 172,414,639 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	172,087,229 - 172,122,885 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	2	172,204,493 - 172,240,144	NCBI
Celera	2	165,995,455 - 166,031,219 (+)	NCBI		Celera
Cytogenetic Map	2	q31.1	NCBI
HuRef	2	164,264,213 - 164,300,158 (+)	NCBI		HuRef
CHM1_1	2	172,385,534 - 172,421,413 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	2	171,999,382 - 172,035,283 (+)	NCBI		T2T-CHM13v2.0

Cybrd1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	70,948,398 - 70,973,270 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	70,948,267 - 70,973,270 (+)	Ensembl		GRCm39 Ensembl
GRCm38	2	71,118,054 - 71,142,926 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	71,117,923 - 71,142,926 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	70,956,111 - 70,980,983 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	2	70,913,320 - 70,943,769 (+)	NCBI		MGSCv36	mm8
Celera	2	72,782,272 - 72,807,772 (+)	NCBI		Celera
Cytogenetic Map	2	C2	NCBI
cM Map	2	42.38	NCBI

LOC102019452
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955449	3,368,670 - 3,394,306 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955449	3,368,976 - 3,394,405 (-)	NCBI	ChiLan1.0	ChiLan1.0

LOC100972759
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	13	74,199,308 - 74,237,028 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	2B	74,214,272 - 74,252,005 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	2B	58,813,554 - 58,849,162 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	2B	176,272,010 - 176,307,618 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	2B	176,272,010 - 176,307,618 (+)	Ensembl	panpan1.1		panPan2

CYBRD1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	36	15,970,873 - 16,001,296 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	36	15,970,946 - 15,997,983 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	36	15,980,919 - 16,011,331 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	36	16,094,110 - 16,124,607 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	36	16,094,120 - 16,124,603 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	36	16,179,767 - 16,210,220 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	36	16,179,569 - 16,209,953 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	36	16,281,609 - 16,312,312 (+)	NCBI		UU_Cfam_GSD_1.0

LOC101976046
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405303	133,216,918 - 133,245,746 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936509	1,770,477 - 1,800,619 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936509	1,770,931 - 1,797,442 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CYBRD1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	15	77,649,040 - 77,695,138 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	15	77,649,124 - 77,695,141 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	15	87,033,652 - 87,079,560 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

CYBRD1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	10	57,034,961 - 57,063,560 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	10	57,035,238 - 57,063,682 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666040	142,482,438 - 142,510,882 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

LOC101701182
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624787	8,937,620 - 8,964,737 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624787	8,937,521 - 8,965,279 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Cybrd1
135 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	610
Count of miRNA genes:	269
Interacting mature miRNAs:	339
Transcripts:	ENSRNOT00000012942
Prediction methods:	Microtar, Miranda, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1582238	Bw68	Body weight QTL 68	3.2	0.0064	body mass (VT:0001259)	body weight (CMO:0000012)	3	53184593	115665732	Rat
1582239	Epfw1	Epididymal fat weight QTL 1	4.5	0.0006	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	3	53184593	115665732	Rat
2298542	Neuinf11	Neuroinflammation QTL 11	3.9		nervous system integrity trait (VT:0010566)	spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)	3	15005422	76927699	Rat
1358362	Srcrt2	Stress Responsive Cort QTL 2	2.78		blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	3	38192233	133483320	Rat
737818	Hcar12	Hepatocarcinoma resistance QTL 12	2.6		liver integrity trait (VT:0010547)	volume of individual liver tumorous lesion (CMO:0001078)	3	29463235	118376539	Rat
1582218	Bw74	Body weight QTL 74	3.9	0.0021	body mass (VT:0001259)	body weight (CMO:0000012)	3	53184593	115665732	Rat
9590286	Uminl1	Urine mineral level QTL 1	3.5	0.001	urine mineral amount (VT:0015086)	urine electrolyte level (CMO:0000593)	3	28249687	73249687	Rat
724523	Tsu1	Thymus enlargement suppressive QTL 1	3.84		thymus mass (VT:0004954)	thymus weight to body weight ratio (CMO:0000612)	3	50437504	115638231	Rat
1581503	Cm58	Cardiac mass QTL 58	2.7	0.05	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	3	43827364	121056321	Rat
2292613	Ept16	Estrogen-induced pituitary tumorigenesis QTL 16	8.3		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	3	47233430	110362260	Rat
731180	Bp152	Blood pressure QTL 152		0.03	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	53781112	91609953	Rat
61356	Bp37	Blood pressure QTL 37	3		blood pressure trait (VT:0000183)	systolic blood pressure (CMO:0000004)	3	30684642	75684642	Rat
1358905	Hrtrt17	Heart rate QTL 17	5.9	0.000014	heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	3	10861912	89878372	Rat
8694196	Abfw2	Abdominal fat weight QTL 2	16.58	0.001	visceral adipose mass (VT:0010063)	abdominal fat pad weight to body weight ratio (CMO:0000095)	3	28249687	73249687	Rat
2301971	Cm71	Cardiac mass QTL 71	4.63		heart left ventricle mass (VT:0007031)	heart left ventricle weight (CMO:0000776)	3	41874578	155617519	Rat
1358885	Bp251	Blood pressure QTL 251	3.8		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	14489145	121056321	Rat
2301970	Bw81	Body weight QTL 81	5.19		body mass (VT:0001259)	body weight (CMO:0000012)	3	41874578	155617519	Rat
1582249	Bw77	Body weight QTL 77	3.2	0.0025	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	3	53184593	64655484	Rat
2290452	Scl56	Serum cholesterol level QTL 56	2.26		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	3	1	91609953	Rat
12879868	Am6	Aortic mass QTL 6		0.001	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	3	31426403	70668733	Rat
11565451	Bw177	Body weight QTL 177		0.002	body mass (VT:0001259)	body weight (CMO:0000012)	3	31426403	70668733	Rat
1358888	Bp264	Blood pressure QTL 264	4.43		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	14489145	121056321	Rat
11565452	Kidm57	Kidney mass QTL 57		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	3	31426403	70668733	Rat
12879866	Cm94	Cardiac mass QTL 94		0.001	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	3	31426403	70668733	Rat
12879867	Cm95	Cardiac mass QTL 95		0.047	heart right ventricle mass (VT:0007033)	heart right ventricle weight to body weight ratio (CMO:0000914)	3	31426403	70668733	Rat
1300178	Hrtrt4	Heart rate QTL 4	3.74		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	3	43827364	90905114	Rat
61377	Edpm3	Estrogen-dependent pituitary mass QTL 3	7.05	0.038	pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	3	53184692	89878207	Rat
2302055	Pia30	Pristane induced arthritis QTL 30	3.5	0.001	blood autoantibody amount (VT:0003725)	serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)	3	27936919	72936919	Rat
1331795	Rf30	Renal function QTL 30	3.708		urine potassium amount (VT:0010539)	urine potassium level (CMO:0000128)	3	39454637	89115240	Rat
70216	Cm14	Cardiac mass QTL 14	2.1		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	3	31172320	163586636	Rat
1354589	Bw31	Body weight QTL 31	3.3		body mass (VT:0001259)	body weight (CMO:0000012)	3	33703347	78196190	Rat
2303593	Gluco46	Glucose level QTL 46	3		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	3	28468571	73468571	Rat
1354590	Despr11	Despair related QTL 11		0.000031	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	3	28468571	73468571	Rat
2292591	Esta4	Estrogen-induced thymic atrophy QTL 4			thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	3	47233211	147415807	Rat
1331777	Bw24	Body weight QTL 24	3.503		body mass (VT:0001259)	body weight (CMO:0000012)	3	39454637	89115240	Rat
631647	Bp122	Blood pressure QTL 122	6.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	30684642	75684642	Rat
1300169	Bp177	Blood pressure QTL 177	2.96		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	3	33703347	61017857	Rat
1559282	Emca5	Estrogen-induced mammary cancer QTL 5	3.9		mammary gland integrity trait (VT:0010552)	percentage of study population developing mammary tumors during a period of time (CMO:0000948)	3	43827364	169034231	Rat
2302276	Bw82	Body weight QTL 82	4.32		body mass (VT:0001259)	body weight (CMO:0000012)	3	39454637	62951183	Rat
738019	Anxrr10	Anxiety related response QTL 10	3.9		exploratory behavior trait (VT:0010471)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	3	38517803	83517803	Rat
9590136	Scort3	Serum corticosterone level QTL 3	23.37	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	3	28249687	73249687	Rat
10450804	Scl70	Serum cholesterol level QTL 70	4.7	0.001	blood LDL cholesterol amount (VT:0000181)	blood low density lipoprotein cholesterol level (CMO:0000053)	3	20714090	65714090	Rat
61419	Cia11	Collagen induced arthritis QTL 11	5.6		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	3	30356773	98535386	Rat
1354597	Kidm13	Kidney mass QTL 13	2.9		kidney mass (VT:0002707)	right kidney wet weight (CMO:0000082)	3	41874578	104104347	Rat
8552950	Pigfal12	Plasma insulin-like growth factor 1 level QTL 12	7.3		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	3	28249687	73249687	Rat
631676	Cm8	Cardiac mass QTL 8	7.03	0.0001	aorta mass (VT:0002845)	aorta weight (CMO:0000076)	3	16954708	61954708	Rat
10450794	Scl69	Serum cholesterol level QTL 69	6.3	0.001	blood LDL cholesterol amount (VT:0000181)	blood low density lipoprotein cholesterol level (CMO:0000053)	3	20714090	65714090	Rat
8694386	Bw159	Body weight QTL 159	4.52	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	3	28249687	73249687	Rat
1354604	Bw36	Body weight QTL 36	2.9		body mass (VT:0001259)	body weight (CMO:0000012)	3	33703347	104104347	Rat
631665	Bw8	Body weight QTL 8	5.5		body mass (VT:0001259)	body weight (CMO:0000012)	3	50437042	119183768	Rat
2301400	Cm68	Cardiac mass QTL 68		0.001	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	3	31426403	70668733	Rat
1358186	Ept2	Estrogen-induced pituitary tumorigenesis QTL 2	8.3		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	3	47233430	110362260	Rat

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001011954	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063283275	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC107446	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC085768	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473949	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000003	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000012942 ⟹ ENSRNOP00000012942

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	3	55,934,874 - 55,962,108 (+)	Ensembl
Rnor_6.0 Ensembl	3	57,718,364 - 57,746,097 (+)	Ensembl

RefSeq Acc Id:

NM_001011954 ⟹ NP_001011954

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	76,342,593 - 76,369,846 (+)	NCBI
mRatBN7.2	3	55,934,874 - 55,962,132 (+)	NCBI
Rnor_6.0	3	57,718,496 - 57,745,749 (+)	NCBI
Rnor_5.0	3	64,212,933 - 64,240,184 (+)	NCBI
RGSC_v3.4	3	53,381,122 - 53,408,375 (+)	RGD
Celera	3	55,482,564 - 55,509,842 (+)	RGD

Sequence:

show sequence

TGCTGATGGCCATGGAAGGCTACCGGGGCTTCCTGGGACTGCTGGTGTCCGCGCTGCTCGTGGG
CTTCCTGTCGGTGATCTTCGTGCTCATCTGGGTCCTGCACTTCCGAGAGGGGCTTGGCTGGGAC
GGCGGCGCGCTCGAGTTTAACTGGCACCCGGTGCTCGCCGTGACCGGCTTCGTCTTCATCCAGG
GCATCGCCATCATCGTGTACAGATTGCCATGGACCTGGAAGTGCAGCAAGTTCTTGATGAAATC
CATCCACGCCGGGTTAAACGCTGTGGCTGCCATCCTGGCCATCATCTCAGTCGTGGCCGTGTTT
GATTATCACAATGTCCGAAAAATCCCCCACATGTACAGTCTGCACAGCTGGGTTGGACTGACAG
TTCTCATACTCTACATCCAACAGCTTGTTGTAGGCTTTTTCATCTTTCTGCTTCCATGGGCTCC
GCCCTCTCTCCGGGCAATCGTCATGCCCATACATGTGTATTCTGGACTCCTCCTCTTTGGAACA
GTGATTGCCACGGTCCTCATGGGAGTGACGGAAAAGCTGTTCTTTGTCCTGAAAAATCCTTCGT
ACCATTCATTCCCACCAGAAGGTGTTTTTACAAATACCCTGGGCCTTCTGATTCTGGTATTTGG
AGCCCTCATCTTTTGGATTGTCACCAGGCCACAATGGAAACGCCCTAGGGAACCAGGCTCTATC
CCTCTTCAGCTAAATGGAGGCAACGCAGACGGAATGGAGGGCGCCATAGCAATAAGCTCCGCCC
ACAACATGGACGCTGCAGACGCAGAGTTAAGCAGCGAGGGAGCAGCCCGGAAAAGAACCCTCGG
CCTTGTTGACACTGGCCAGAGGTCCACCATGTGAAATGTTGATGCAGCCACGTAACTTCTCTTC
CAAAGTCAGCCCTACGATTTAGCTTCTCCTACCTAGCCATAGGCCGATGTATATTGTGGTAACC
AAGGAGGTTTTCCTGAGAGCGATTGTGTTGACTGAGGCCTGTAAACTTACCAAATGTAAAAGGA
CATGATCAATATAAGTTGTGATTGTTTCCTCTTTCCTCTTGAGGACCCGGGCGTTGGATGTACC
TGCCAGTGGGTTGTCTGATGAACTGGTAGCACCCTTGGCCTCTGGCTATGCCCCATTAATTCGG
GGAGCCCAGTGATTTCAGAACTAGGTAGAACCTCTCTTAATCTTTAAAATTAGATCACAAATAC
CTGGAGAGGGATTTGGATCATTGTGCCACAAAGATATTGTGAGGAAAACATGGGGGTGGCAGCG
GTGGTGGTGCCTTAGGAAAATATCTAGTTCCCTCTCCAGCTGATTTGGCCTCACACAGACTCTG
AACGTGACAGAATATACGAGGGTGTTTTGGAGCAGTTTGGTTAGTTGCAGACAGCTGAAGAGAT
CTCTGGTTAGACTTGGAAGCTTTTGTAACACTCAGTCCAGTGCCAGTACTCCGAGGAGCCGGTA
TACTTCACGGTTCAGCTTCTGAACCTCTTGCAATGCAAACACGCTCAGGCCCCATAAACCCGCC
TTGTGTCCGCAGCCTGTGAAGGGTGCCCTCGAGATTCTGTTTTTATTTTCCAAAGTGCTTCTCT
AGCTCTTACTATGTGCTTTACAAATATTAGCTCCTTCAGTCTCCAGACAGACTCTGCGAGACAG
GTATTGTAACTAGCCCCATTTTAGGTGAAAGATCTGAAGCTTGGAAAGGTTATAACTTGGCCCA
GCATCACACACTTCTTTAATTGGTGGAACTGACATTCAAACCCTGGCGGTCTGGCTCCTCTGCC
CAAGATCCTATATTTCACCATATTCCTTCCCCTGTTTATTCTAATTGGCAGCACTATGGTCTAC
CTAGGAATAAAGTTGCAGATGAAGGCTAGTGGAATTGTTACAGGATGCTGCCTTACCTTTGGTC
CTCTTCCAAGGGGACCCCTTAGATGATGGGAAAGGCGCCGGAAAGACTTGGATGGAGATCCTGG
GGCATTAGCCATTGCCAACAAGCCAGAGCCTGCCTTGATGCTCTCTAATTTTAACAGGGCATCT
GTCTTGCCGACAAGAAGACTTGGACGAGGATACTCACAGCCTTCAAGCCATTACCATACTGGTT
CCTCGGGATCTTAGCGGCTGAACACAATTTGGAAACACACATATCCTGGTCTGCCCTTCCCTCG
GACCATAGGCAGGTTCCTTCCTGATTTCTGTGGAATTTGGAGTTCTTAGCAGGGAGCTGAGATT
TAGAAGTGATTTTCACATGGCCAGACTTCTCTCTCAGCTCTGATGGAAACCTGCAGTAGTAACT
GGGCCAAAACGATGCCTGTAGCGGGTAGTTTAGGCGACTGTGCTCTGAGCTCTCAGACAGTCGC
AGGCTCGTACCTGCCCAGGAGCTCTCTTCGATCCGAGGATGAAAGACACGCACATTAGCTAATT
TTTAAGTTGCCTTATTGGGTGTGTGGCTGAGCTCTTCTAAGCCATCCACGGCTACCATGCGCTT
ACCTTTACTCCTAGCTCAACATCTCTAAATCTACCCTCAACTTAGTTGCCCGCTCACTTTCTGC
GAAGCCCATTGGTCTTGCTGCTCAAGATGCTCTCAGGCTGCCCTTCCGTGGGCTGCTTTCCTTT
TCCGCCTACATTTTGGAAGATCTCCCCTGCAGCTCTGAGTCTATTCCACCTCTCTCCCCCAAGT
ACCTTAGTTCTACCTTTTCCACCTTCTCTCCTAGCCTGCAGAAACCTGGAAGTCCCGCCTATTT
CCGCCCAGCCATTGACCACTGGCATCTTTATTGATAGATCAAAAACCAATTGGGAGCAAGGACC
TTTAGTGTCAGTAAACACAGATTCCCGACTAAATCAAAGCTTCAAACCACTCCTCTACAGAGGC
CTGGTGCAGATTGCCTGGTTTTTGGTTTCTCTGCATTTTCTGATTGAGGCACTTGGGCACTAAA
GTGTGAGCCTTGTAGTTCCAGCTGCTCGAGAGGCTGAACTTAAGGTACAGTTCAAGGCCAGCCT
GGGCAACTGAGTGAAACTCTCTCTTAGGATTTTGGTTTCTCTAGTAACCCAAGTTGGCCTCTCT
CGTTGTATAATTAAGGGTGACCTTGAAGACGTGGTTCTCCTTGCCTTCCCAAAGCTGGATGACA
GGCGTGTACCACCAGCCACTGTGCCTTAGCACGGCTCCGTCTTTTAAATAAATAAAGCCAAACC
AAACAAGAATTTTAAGATGGAGAGAAAAAACGTGTAGTTTACAGAGAAATACACTTAACATGTT
TGGCGTGTAGCGAAATTCCTTTTAGGTAACATGATTTATTTCCAAAAGACCAAATACGGGGCGG
GGTTGGGGATTTAGCTCAGTGGTAGAGCACTTGCCTAGCAAGCGCAAGGCCCTGGGTTCGGTCC
TCAGCTCCGGAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_063283275 ⟹ XP_063139345

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	76,342,231 - 76,367,456 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001011954	(Get FASTA)	NCBI Sequence Viewer
	XP_063139345	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH85768	(Get FASTA)	NCBI Sequence Viewer
	EDL79093	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000012942
	ENSRNOP00000012942.4
GenBank Protein	Q5RKJ2	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_001011954 ⟸ NM_001011954

- UniProtKB:

Q5RKJ2 (UniProtKB/Swiss-Prot), A6HM42 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MAMEGYRGFLGLLVSALLVGFLSVIFVLIWVLHFREGLGWDGGALEFNWHPVLAVTGFVFIQGI
AIIVYRLPWTWKCSKFLMKSIHAGLNAVAAILAIISVVAVFDYHNVRKIPHMYSLHSWVGLTVL
ILYIQQLVVGFFIFLLPWAPPSLRAIVMPIHVYSGLLLFGTVIATVLMGVTEKLFFVLKNPSYH
SFPPEGVFTNTLGLLILVFGALIFWIVTRPQWKRPREPGSIPLQLNGGNADGMEGAIAISSAHN
MDAADAELSSEGAARKRTLGLVDTGQRSTM

hide sequence

Ensembl Acc Id:

ENSRNOP00000012942 ⟸ ENSRNOT00000012942

RefSeq Acc Id:	XP_063139345 ⟸ XM_063283275
- Peptide Label:	isoform X1

Protein Domains

Cytochrome b561

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q5RKJ2-F1-model_v2	AlphaFold	Q5RKJ2	1-286	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13692133

Promoter ID:

EPDNEW_R2657

Type:

initiation region

Name:

Cybrd1_1

Description:

cytochrome b reductase 1

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	3	57,718,432 - 57,718,492	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1305740	AgrOrtholog
BioCyc Gene	G2FUF-49477	BioCyc
Ensembl Genes	ENSRNOG00000009620	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000012942	ENTREZGENE
	ENSRNOT00000012942.7	UniProtKB/Swiss-Prot
Gene3D-CATH	1.20.120.1770	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:7108043	IMAGE-MGC_LOAD
InterPro	CYB561/CYBRD1-like	UniProtKB/Swiss-Prot
	Cyt_b561/ferric_Rdtase_TM	UniProtKB/Swiss-Prot
KEGG Report	rno:295669	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:93676	IMAGE-MGC_LOAD
NCBI Gene	295669	ENTREZGENE
PANTHER	PTHR10106	UniProtKB/Swiss-Prot
	PTHR10106:SF12	UniProtKB/Swiss-Prot
Pfam	Cytochrom_B561	UniProtKB/Swiss-Prot
PhenoGen	Cybrd1	PhenoGen
PROSITE	CYTOCHROME_B561	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000009620	RatGTEx
SMART	B561	UniProtKB/Swiss-Prot
UniProt	A6HM42	ENTREZGENE, UniProtKB/TrEMBL
	CYBR1_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2005-12-06	Cybrd1	cytochrome b reductase 1	Cybrd1_predicted	cytochrome b reductase 1 (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-12	Cybrd1_predicted	cytochrome b reductase 1 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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RGD Manual Annotations