Mroh2b (maestro heat-like repeat family member 2B) - Rat Genome Database

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Gene: Mroh2b (maestro heat-like repeat family member 2B) Rattus norvegicus
Analyze
Symbol: Mroh2b
Name: maestro heat-like repeat family member 2B
RGD ID: 1305413
Description: Predicted to be involved in protein kinase A signaling. Predicted to be located in acrosomal vesicle and sperm midpiece. Orthologous to human MROH2B (maestro heat like repeat family member 2B); INTERACTS WITH acrylamide; atrazine; lead nitrate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: HEAT repeat family member 7B2; HEAT repeat-containing protein 7B2; Heatr7b2; LOC102553573; LOC361902; maestro heat-like repeat-containing protein family member 2B; RGD1305413; similar to FLJ40243 protein; uncharacterized LOC102553573
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2254,003,870 - 54,063,992 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl254,003,862 - 54,063,984 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx261,115,950 - 61,173,486 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0259,174,634 - 59,232,166 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0254,182,500 - 54,240,010 (+)NCBIRnor_WKY
Rnor_6.0254,621,140 - 54,675,142 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0273,646,764 - 73,713,660 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4254,098,254 - 54,118,036 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1253,851,950 - 54,046,237 (+)NCBI
Celera249,655,507 - 49,715,921 (+)NCBICelera
Cytogenetic Map2q16NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12783626   PMID:27105888  


Genomics

Comparative Map Data
Mroh2b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2254,003,870 - 54,063,992 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl254,003,862 - 54,063,984 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx261,115,950 - 61,173,486 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0259,174,634 - 59,232,166 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0254,182,500 - 54,240,010 (+)NCBIRnor_WKY
Rnor_6.0254,621,140 - 54,675,142 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0273,646,764 - 73,713,660 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4254,098,254 - 54,118,036 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1253,851,950 - 54,046,237 (+)NCBI
Celera249,655,507 - 49,715,921 (+)NCBICelera
Cytogenetic Map2q16NCBI
MROH2B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38540,998,020 - 41,071,342 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl540,998,017 - 41,071,342 (-)EnsemblGRCh38hg38GRCh38
GRCh37540,998,122 - 41,071,444 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36541,033,879 - 41,107,201 (-)NCBINCBI36Build 36hg18NCBI36
Celera540,886,706 - 40,960,038 (-)NCBICelera
Cytogenetic Map5p13.1NCBI
HuRef540,950,091 - 41,023,450 (-)NCBIHuRef
CHM1_1541,000,124 - 41,073,451 (-)NCBICHM1_1
T2T-CHM13v2.0541,254,444 - 41,327,790 (-)NCBIT2T-CHM13v2.0
Mroh2b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39154,927,697 - 4,991,689 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl154,928,219 - 4,991,687 (+)EnsemblGRCm39 Ensembl
GRCm38154,898,215 - 4,962,207 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl154,898,737 - 4,962,205 (+)EnsemblGRCm38mm10GRCm38
MGSCv37154,848,737 - 4,912,203 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36154,846,402 - 4,909,418 (+)NCBIMGSCv36mm8
Celera154,749,005 - 4,811,892 (+)NCBICelera
Cytogenetic Map15A1NCBI
Mroh2b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542625,237,272 - 25,312,082 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542625,245,920 - 25,311,757 (-)NCBIChiLan1.0ChiLan1.0
MROH2B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1574,359,683 - 74,432,447 (+)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v0569,316,605 - 69,389,958 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
MROH2B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1468,369,175 - 68,432,433 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl468,370,210 - 68,432,432 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha468,052,250 - 68,115,487 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0468,881,691 - 68,944,699 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl468,881,636 - 68,944,698 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1468,642,867 - 68,704,780 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0468,754,892 - 68,817,156 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0469,293,102 - 69,356,037 (+)NCBIUU_Cfam_GSD_1.0
Mroh2b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213229,706,220 - 229,785,003 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365181,593,156 - 1,665,577 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049365181,593,156 - 1,665,577 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MROH2B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1625,919,679 - 25,985,273 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11625,920,647 - 25,985,074 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21627,005,559 - 27,038,380 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MROH2B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1439,772,623 - 39,848,262 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl439,772,655 - 39,846,191 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607130,200,253 - 30,274,388 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mroh2b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475913,924,050 - 13,981,645 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475913,906,288 - 13,981,645 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Mroh2b
389 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61355Bp36Blood pressure QTL 362.9blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)25873687102844969Rat
738012Anxrr3Anxiety related response QTL 33.8exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)2902351954023519Rat
10755430Coatc6Coat color QTL 60.02576coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)21159110056591100Rat
731184Mamtr4Mammary tumor resistance QTL 40.0003mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)21649174061491740Rat
1357990Ael1Aortic elastin QTL 13.10.00091aorta elastin amount (VT:0003905)aortic elastin21907682564076825Rat
731167Glom4Glomerulus QTL 42.40.0082kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)22030467265304672Rat
2300168Bmd47Bone mineral density QTL 476.60.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)22066244865662448Rat
10402051Gdil2Gastrointestinal dilation QTL 2enteric ganglion morphology trait (VT:0001045)length of intestine affected by colonic aganglionosis to total length of colon ratio (CMO:0001836)22490385374786777Rat
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)225413423143657569Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
1354617Bp240Blood pressure QTL 2404arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)22691781781754745Rat
1354617Bp240Blood pressure QTL 2404arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)22691781781754745Rat
1354617Bp240Blood pressure QTL 2404arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)22691781781754745Rat
1354603Bp243Blood pressure QTL 2433.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)226917817127469484Rat
2290453Scl55Serum cholesterol level QTL 552.83blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)226917817136917119Rat
9590095Sffal3Serum free fatty acids level QTL 36.780.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)22715716072157160Rat
10755434Coatc7Coat color QTL 70.04794coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)23064806575648065Rat
10755436Coatc8Coat color QTL 80.02431coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)23502311780023117Rat
61371Edpm1Estrogen-dependent pituitary mass QTL 140.05pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)23513484188029593Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)240067944102785628Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)240067944102785628Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)240067944102785628Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)240067944102785628Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)240067944102785628Rat
12879863Bp402Blood pressure QTL 4020.003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)24112578956532139Rat
1300155Bp174Blood pressure QTL 1744.09arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)24280460760653831Rat
2293835Kiddil5Kidney dilation QTL 53.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607157142209Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607182042367Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)243154682202446871Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)243154682202446871Rat
2293676Bmd19Bone mineral density QTL 1910.70.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)243162366111362592Rat
2293682Bmd24Bone mineral density QTL 248.90.0001femur mineral mass (VT:0010011)cortical volumetric bone mineral density (CMO:0001730)243162366111362592Rat
2293671Bss44Bone structure and strength QTL 4410.970.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)243162366148478373Rat
631208Bw1Body weight QTL15.09mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)24317101783575226Rat
1354601Slep1Serum leptin concentration QTL 15.39blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)243171017184114403Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)246123260202447032Rat
1354592Rf50Renal function QTL 503.5urine output (VT:0003620)timed urine volume (CMO:0000260)25382274774786777Rat


Expression


Sequence


Reference Sequences
RefSeq Acc Id: NM_001047908   ⟹   NP_001041373
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2254,006,472 - 54,063,984 (+)NCBI
RefSeq Acc Id: XM_039102574   ⟹   XP_038958502
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2254,003,870 - 54,063,992 (+)NCBI
RefSeq Acc Id: XM_039102575   ⟹   XP_038958503
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2254,003,870 - 54,060,937 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001041373 (Get FASTA)   NCBI Sequence Viewer  
  XP_038958502 (Get FASTA)   NCBI Sequence Viewer  
  XP_038958503 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein DAA01460 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_038958502   ⟸   XM_039102574
- Peptide Label: isoform X1
- UniProtKB: A0A8J8YRC8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038958503   ⟸   XM_039102575
- Peptide Label: isoform X2
RefSeq Acc Id: NP_001041373   ⟸   NM_001047908

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q7M6Y9-F1-model_v2 AlphaFold Q7M6Y9 1-563 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1305413 AgrOrtholog
BioCyc Gene G2FUF-54185 BioCyc
Ensembl Genes ENSRNOG00000042327 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000057119 ENTREZGENE
  ENSRNOP00000057119.5 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000060376 ENTREZGENE
  ENSRNOT00000060376.5 UniProtKB/TrEMBL
Gene3D-CATH 1.25.10.10 UniProtKB/TrEMBL
InterPro ARM-like UniProtKB/TrEMBL
  ARM-type_fold UniProtKB/TrEMBL
  Maestro_heat-like_prot UniProtKB/TrEMBL
NCBI Gene 361902 ENTREZGENE
PANTHER PTHR23120 UniProtKB/TrEMBL
PhenoGen Mroh2b PhenoGen
Superfamily-SCOP SSF48371 UniProtKB/TrEMBL
UniProt A0A8J8YRC8 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Mroh2b  maestro heat-like repeat family member 2B  LOC102553573  uncharacterized LOC102553573  Data Merged 737654 PROVISIONAL
2013-12-18 LOC102553573  uncharacterized LOC102553573      Symbol and Name status set to provisional 70820 PROVISIONAL
2013-01-02 Mroh2b  maestro heat-like repeat family member 2B  Heatr7b2  HEAT repeat family member 7B2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-12-30 Heatr7b2  HEAT repeat family member 7B2  RGD1305413  similar to FLJ40243 protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1305413  similar to FLJ40243 protein  RGD1305413_predicted  similar to FLJ40243 protein (predicted)  Symbol and Name status set to approved 1299863 APPROVED
2005-01-20 RGD1305413_predicted  similar to FLJ40243 protein (predicted)  LOC361902_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC361902_predicted  similar to FLJ40243 protein (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL