Mdm2 Rat (+)-catechin decreases expression ISO MDM2 (Homo sapiens) 6480464 Catechin results in decreased expression of MDM2 mRNA CTD PMID:23706674 Mdm2 Rat (+)-schisandrin B multiple interactions EXP 6480464 schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of MDM2 mRNA] CTD PMID:31150632 Mdm2 Rat (-)-demecolcine increases expression ISO MDM2 (Homo sapiens) 6480464 Demecolcine results in increased expression of MDM2 mRNA CTD PMID:23649840 Mdm2 Rat (-)-epigallocatechin 3-gallate multiple interactions ISO Mdm2 (Mus musculus) 6480464 [epigallocatechin gallate co-treated with polylactic acid-polyglycolic acid copolymer analog] inhibits the reaction [9 more ... CTD PMID:23717041 Mdm2 Rat (S)-naringenin multiple interactions ISO MDM2 (Homo sapiens) 6480464 [naringenin co-treated with bisphenol A] results in increased expression of MDM2 mRNA and [naringenin metabolite co-treated with bisphenol A] results in increased expression of MDM2 mRNA CTD PMID:36235125 Mdm2 Rat (S)-naringenin increases expression ISO MDM2 (Homo sapiens) 6480464 naringenin metabolite results in increased expression of MDM2 mRNA CTD PMID:36235125 Mdm2 Rat (S)-nicotine multiple interactions ISO MDM2 (Homo sapiens) 6480464 [[Nicotine results in decreased expression of RPS27A protein] which results in increased phosphorylation of MDM2 protein] which results in increased ubiquitination of TP53 protein and [Nicotine results in decreased expression of RPS27A protein] which results in increased phosphorylation of MDM2 protein CTD PMID:30272249 Mdm2 Rat 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane affects expression ISO Mdm2 (Mus musculus) 6480464 o and p'-DDT affects the expression of MDM2 mRNA CTD PMID:18925944 Mdm2 Rat 1,10-phenanthroline increases expression ISO MDM2 (Homo sapiens) 6480464 1 and 10-phenanthroline results in increased expression of MDM2 mRNA CTD PMID:19502547 Mdm2 Rat 1,2-dimethylhydrazine multiple interactions ISO Mdm2 (Mus musculus) 6480464 [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in increased expression of MDM2 mRNA CTD PMID:22206623 Mdm2 Rat 1-nitropyrene increases expression ISO MDM2 (Homo sapiens) 6480464 1-nitropyrene results in increased expression of MDM2 mRNA more ... CTD PMID:10837373 and PMID:22044530 Mdm2 Rat 1-nitropyrene multiple interactions ISO MDM2 (Homo sapiens) 6480464 nutlin 3 results in increased susceptibility to [1-nitropyrene results in increased expression of MDM2 protein modified form] more ... CTD PMID:10837373 and PMID:22044530 Mdm2 Rat 10-Hydroxycamptothecin affects response to substance ISO MDM2 (Homo sapiens) 6480464 MDM2 protein affects the susceptibility to 10-hydroxycamptothecin CTD PMID:13130078 Mdm2 Rat 17alpha-ethynylestradiol increases expression ISO MDM2 (Homo sapiens) 6480464 Ethinyl Estradiol results in increased expression of MDM2 mRNA alternative form and Ethinyl Estradiol results in increased expression of MDM2 protein CTD PMID:12168835 Mdm2 Rat 17alpha-ethynylestradiol increases expression ISO Mdm2 (Mus musculus) 6480464 Ethinyl Estradiol results in increased expression of MDM2 mRNA CTD PMID:17942748 Mdm2 Rat 17alpha-ethynylestradiol multiple interactions ISO Mdm2 (Mus musculus) 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MDM2 mRNA CTD PMID:17942748 Mdm2 Rat 17alpha-ethynylestradiol affects expression ISO Mdm2 (Mus musculus) 6480464 Ethinyl Estradiol affects the expression of MDM2 mRNA CTD PMID:17555576 Mdm2 Rat 17beta-estradiol increases expression ISO MDM2 (Homo sapiens) 6480464 Estradiol results in increased expression of MDM2 mRNA alternative form and Estradiol results in increased expression of MDM2 protein CTD PMID:12168835 Mdm2 Rat 17beta-estradiol increases expression ISO Mdm2 (Mus musculus) 6480464 Estradiol results in increased expression of MDM2 mRNA and Estradiol results in increased expression of MDM2 protein CTD PMID:23684557 Mdm2 Rat 17beta-estradiol multiple interactions ISO MDM2 (Homo sapiens) 6480464 [Estradiol co-treated with Parathion] results in increased expression of MDM2 mRNA and [Estradiol co-treated with TGFB1 protein] results in decreased expression of MDM2 mRNA CTD PMID:17622325 and PMID:30165855 Mdm2 Rat 17beta-estradiol decreases phosphorylation ISO Mdm2 (Mus musculus) 6480464 Estradiol results in decreased phosphorylation of MDM2 protein CTD PMID:22314386 Mdm2 Rat 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one increases expression ISO MDM2 (Homo sapiens) 6480464 1H-(1 more ... CTD PMID:16288207 Mdm2 Rat 2,2',3,3',6,6'-hexachlorobiphenyl increases phosphorylation ISO MDM2 (Homo sapiens) 6480464 2 more ... CTD PMID:19751709 Mdm2 Rat 2,2',4,4',5,5'-hexachlorobiphenyl multiple interactions ISO MDM2 (Homo sapiens) 6480464 2 more ... CTD PMID:20840854 Mdm2 Rat 2,2',4,4',5,5'-hexachlorobiphenyl increases phosphorylation ISO MDM2 (Homo sapiens) 6480464 2 more ... CTD PMID:19751709 and PMID:20840854 Mdm2 Rat 2,2',4,4'-tetrachlorobiphenyl increases phosphorylation ISO MDM2 (Homo sapiens) 6480464 2 more ... CTD PMID:19751709 Mdm2 Rat 2,2',4,5-tetrachlorobiphenyl increases phosphorylation ISO MDM2 (Homo sapiens) 6480464 2 more ... CTD PMID:19751709 Mdm2 Rat 2,2',5,5'-tetrachlorobiphenyl increases phosphorylation ISO MDM2 (Homo sapiens) 6480464 2 more ... CTD PMID:19751709 Mdm2 Rat 2,2-bis(hydroxymethyl)-1-azabicyclo[2.2.2]octan-3-one increases expression ISO MDM2 (Homo sapiens) 6480464 2 more ... CTD PMID:21647879 Mdm2 Rat 2,3,3',4,4',5,5'-Heptachlorobiphenyl increases phosphorylation ISO MDM2 (Homo sapiens) 6480464 2 more ... CTD PMID:19751709 Mdm2 Rat 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO MDM2 (Homo sapiens) 6480464 alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [Oxygen deficiency results in increased expression of MDM2 mRNA]] more ... CTD PMID:19578757 and PMID:22044530 Mdm2 Rat 2,3,7,8-tetrachlorodibenzodioxine increases expression EXP 6480464 Tetrachlorodibenzodioxin results in increased expression of MDM2 mRNA CTD PMID:33387578 Mdm2 Rat 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO Mdm2 (Mus musculus) 6480464 Tetrachlorodibenzodioxin results in increased expression of MDM2 mRNA CTD PMID:12167310 more ... Mdm2 Rat 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO Mdm2 (Mus musculus) 6480464 Tetrachlorodibenzodioxin affects the expression of MDM2 mRNA CTD PMID:21570461 Mdm2 Rat 2,3,7,8-tetrachlorodibenzodioxine increases phosphorylation EXP 6480464 Tetrachlorodibenzodioxin results in increased phosphorylation of MDM2 protein CTD PMID:15459018 Mdm2 Rat 2,3,7,8-tetrachlorodibenzodioxine multiple interactions EXP 6480464 Tetrachlorodibenzodioxin inhibits the reaction [Etoposide results in increased expression of MDM2 protein] and Tetrachlorodibenzodioxin results in increased expression of and results in increased phosphorylation of and results in increased activity of MDM2 protein CTD PMID:15459018 Mdm2 Rat 2,3,7,8-tetrachlorodibenzodioxine increases degradation EXP 6480464 Tetrachlorodibenzodioxin results in increased degradation of MDM2 protein CTD PMID:15459018 Mdm2 Rat 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO Mdm2 (Mus musculus) 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MDM2 mRNA CTD PMID:17942748 Mdm2 Rat 2,3,7,8-tetrachlorodibenzodioxine increases phosphorylation ISO MDM2 (Homo sapiens) 6480464 Tetrachlorodibenzodioxin results in increased phosphorylation of MDM2 protein CTD PMID:19751709 Mdm2 Rat 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO MDM2 (Homo sapiens) 6480464 Tetrachlorodibenzodioxin results in increased expression of MDM2 mRNA CTD PMID:19578757 Mdm2 Rat 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO MDM2 (Homo sapiens) 6480464 Tetrachlorodibenzodioxin results in decreased expression of MDM2 mRNA CTD PMID:16039398 Mdm2 Rat 2,4-dinitrotoluene affects expression EXP 6480464 2 and 4-dinitrotoluene affects the expression of MDM2 mRNA CTD PMID:21346803 Mdm2 Rat 2,6-dinitrotoluene affects expression EXP 6480464 2 and 6-dinitrotoluene affects the expression of MDM2 mRNA CTD PMID:21346803 Mdm2 Rat 2-acetamidofluorene multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] affects the expression of and affects the localization of MDM2 protein CTD PMID:11003613 Mdm2 Rat 2-acetamidofluorene increases expression EXP 6480464 2-Acetylaminofluorene results in increased expression of MDM2 mRNA and 2-Acetylaminofluorene results in increased expression of MDM2 protein CTD PMID:19167416 more ... Mdm2 Rat 2-acetamidofluorene increases expression ISO Mdm2 (Mus musculus) 6480464 2-Acetylaminofluorene results in increased expression of MDM2 mRNA CTD PMID:21607683 Mdm2 Rat 2-nitrofluorene increases expression EXP 6480464 2-nitrofluorene results in increased expression of MDM2 mRNA CTD PMID:14600272 more ... Mdm2 Rat 3,3',4,4',5-pentachlorobiphenyl increases phosphorylation ISO MDM2 (Homo sapiens) 6480464 3 more ... CTD PMID:19751709 and PMID:20840854 Mdm2 Rat 3,3',4,4',5-pentachlorobiphenyl multiple interactions ISO MDM2 (Homo sapiens) 6480464 3 more ... CTD PMID:20840854 Mdm2 Rat 3,3'-diindolylmethane decreases expression ISO Mdm2 (Mus musculus) 6480464 3 and 3'-diindolylmethane analog results in decreased expression of MDM2 mRNA CTD PMID:26593444 Mdm2 Rat 3,4,8-Trimethyl-1H,2H,3H-imidazo[4,5-F]quinoxalin-2-imine increases expression ISO MDM2 (Homo sapiens) 6480464 3 more ... CTD PMID:23810796 Mdm2 Rat 3-phenylprop-2-enal increases expression ISO MDM2 (Homo sapiens) 6480464 cinnamaldehyde results in increased expression of MDM2 mRNA CTD PMID:19000754 Mdm2 Rat 4,4'-diaminodiphenylmethane increases expression ISO Mdm2 (Mus musculus) 6480464 4 and 4'-diaminodiphenylmethane results in increased expression of MDM2 mRNA CTD PMID:18648102 Mdm2 Rat 4,4'-sulfonyldiphenol increases methylation ISO Mdm2 (Mus musculus) 6480464 bisphenol S results in increased methylation of MDM2 promoter CTD PMID:33297965 Mdm2 Rat 4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one increases expression EXP 6480464 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of MDM2 mRNA CTD PMID:14600272 more ... Mdm2 Rat 4-hydroperoxycyclophosphamide increases expression ISO MDM2 (Homo sapiens) 6480464 perfosfamide results in increased expression of MDM2 CTD PMID:18034189 Mdm2 Rat 4-hydroxyphenyl retinamide decreases expression ISO MDM2 (Homo sapiens) 6480464 Fenretinide results in decreased expression of MDM2 mRNA CTD PMID:16570282 Mdm2 Rat 4-hydroxyphenyl retinamide increases expression ISO Mdm2 (Mus musculus) 6480464 Fenretinide results in increased expression of MDM2 mRNA CTD PMID:28973697 Mdm2 Rat 5-aza-2'-deoxycytidine affects expression ISO MDM2 (Homo sapiens) 6480464 Decitabine affects the expression of MDM2 mRNA CTD PMID:17145863 Mdm2 Rat 5-azacytidine increases expression ISO MDM2 (Homo sapiens) 6480464 Azacitidine results in increased expression of MDM2 mRNA CTD PMID:20823114 Mdm2 Rat 5-fluorouracil increases expression ISO Mdm2 (Mus musculus) 6480464 Fluorouracil results in increased expression of MDM2 mRNA CTD PMID:16949053 Mdm2 Rat 5-fluorouracil increases phosphorylation ISO MDM2 (Homo sapiens) 6480464 Fluorouracil results in increased phosphorylation of MDM2 protein CTD PMID:25744307 Mdm2 Rat 5-fluorouracil increases expression ISO MDM2 (Homo sapiens) 6480464 Fluorouracil results in increased expression of MDM2 mRNA more ... CTD PMID:14665630 more ... Mdm2 Rat 5-fluorouracil multiple interactions ISO MDM2 (Homo sapiens) 6480464 Cadmium Chloride affects the reaction [Fluorouracil results in increased phosphorylation of MDM2 protein] more ... CTD PMID:15546879 more ... Mdm2 Rat 7,12-dimethyltetraphene multiple interactions ISO Mdm2 (Mus musculus) 6480464 [epigallocatechin gallate co-treated with polylactic acid-polyglycolic acid copolymer analog] inhibits the reaction [9 more ... CTD PMID:23717041 Mdm2 Rat 7,12-dimethyltetraphene increases expression ISO Mdm2 (Mus musculus) 6480464 9 more ... CTD PMID:23717041 and PMID:32553695 Mdm2 Rat acetamide increases expression EXP 6480464 acetamide results in increased expression of MDM2 mRNA CTD PMID:31881176 Mdm2 Rat acetylsalicylic acid decreases expression ISO MDM2 (Homo sapiens) 6480464 Aspirin results in decreased expression of MDM2 mRNA CTD PMID:20457246 Mdm2 Rat actinomycin D increases expression ISO MDM2 (Homo sapiens) 6480464 Dactinomycin results in increased expression of MDM2 mRNA CTD PMID:38460933 Mdm2 Rat actinomycin D multiple interactions ISO MDM2 (Homo sapiens) 6480464 [Dactinomycin co-treated with nutlin 3] results in increased expression of MDM2 mRNA and [Dactinomycin co-treated with nutlin 3] results in increased secretion of MDM2 protein CTD PMID:38460933 Mdm2 Rat adefovir pivoxil increases expression ISO MDM2 (Homo sapiens) 6480464 adefovir dipivoxil results in increased expression of MDM2 mRNA CTD PMID:25596134 Mdm2 Rat aflatoxin B1 affects expression ISO MDM2 (Homo sapiens) 6480464 Aflatoxin B1 affects the expression of MDM2 protein CTD PMID:20106945 Mdm2 Rat aflatoxin B1 increases expression ISO MDM2 (Homo sapiens) 6480464 Aflatoxin B1 results in increased expression of MDM2 mRNA CTD PMID:21632981 more ... Mdm2 Rat aflatoxin B1 decreases methylation ISO MDM2 (Homo sapiens) 6480464 Aflatoxin B1 results in decreased methylation of MDM2 gene CTD PMID:27153756 Mdm2 Rat aflatoxin B1 increases expression EXP 6480464 Aflatoxin B1 results in increased expression of MDM2 mRNA CTD PMID:14600272 more ... Mdm2 Rat aflatoxin B1 increases expression ISO Mdm2 (Mus musculus) 6480464 Aflatoxin B1 results in increased expression of MDM2 mRNA CTD PMID:19770486 Mdm2 Rat aflatoxin M1 decreases expression ISO MDM2 (Homo sapiens) 6480464 Aflatoxin M1 results in decreased expression of MDM2 mRNA CTD PMID:30928695 Mdm2 Rat alpha-naphthoflavone multiple interactions ISO MDM2 (Homo sapiens) 6480464 alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [Oxygen deficiency results in increased expression of MDM2 mRNA]] and alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of MDM2 mRNA] CTD PMID:19578757 Mdm2 Rat alvocidib decreases expression ISO MDM2 (Homo sapiens) 6480464 alvocidib results in decreased expression of MDM2 mRNA and alvocidib results in decreased expression of MDM2 protein CTD PMID:12589031 Mdm2 Rat amifostine decreases expression ISO MDM2 (Homo sapiens) 6480464 Amifostine results in decreased expression of MDM2 mRNA CTD PMID:14555708 Mdm2 Rat amitrole decreases expression EXP 6480464 Amitrole results in decreased expression of MDM2 mRNA CTD PMID:38685447 Mdm2 Rat ammonium chloride increases expression EXP 6480464 Ammonium Chloride results in increased expression of MDM2 mRNA and Ammonium Chloride results in increased expression of MDM2 protein CTD PMID:12420312 and PMID:16483693 Mdm2 Rat amphetamine increases expression EXP 6480464 Amphetamine results in increased expression of MDM2 mRNA CTD PMID:30779732 Mdm2 Rat amphibole asbestos decreases expression ISO MDM2 (Homo sapiens) 6480464 Asbestos and Amphibole results in decreased expression of MDM2 protein CTD PMID:20855422 Mdm2 Rat amsacrine decreases response to substance ISO MDM2 (Homo sapiens) 6480464 MDM2 promoter SNP results in decreased susceptibility to Amsacrine CTD PMID:17575151 Mdm2 Rat androstane multiple interactions ISO Mdm2 (Mus musculus) 6480464 Androstanols inhibits the reaction [DDT results in increased expression of MDM2 mRNA] CTD PMID:23684557 Mdm2 Rat antimycin A increases expression ISO MDM2 (Homo sapiens) 6480464 Antimycin A results in increased expression of MDM2 mRNA CTD PMID:33512557 Mdm2 Rat arsane affects response to substance ISO MDM2 (Homo sapiens) 6480464 MDM2 SNP affects the susceptibility to Arsenic CTD PMID:21982800 Mdm2 Rat arsane increases expression ISO MDM2 (Homo sapiens) 6480464 Arsenic results in increased expression of MDM2 protein CTD PMID:35821281 Mdm2 Rat arsane multiple interactions ISO MDM2 (Homo sapiens) 6480464 USP7 protein affects the reaction [Arsenic results in increased expression of MDM2 protein] CTD PMID:35821281 Mdm2 Rat arsane affects methylation ISO MDM2 (Homo sapiens) 6480464 Arsenic affects the methylation of MDM2 gene CTD PMID:25304211 Mdm2 Rat arsenic atom affects response to substance ISO MDM2 (Homo sapiens) 6480464 MDM2 SNP affects the susceptibility to Arsenic CTD PMID:21982800 Mdm2 Rat arsenic atom increases expression ISO MDM2 (Homo sapiens) 6480464 Arsenic results in increased expression of MDM2 protein CTD PMID:35821281 Mdm2 Rat arsenic atom multiple interactions ISO MDM2 (Homo sapiens) 6480464 USP7 protein affects the reaction [Arsenic results in increased expression of MDM2 protein] CTD PMID:35821281 Mdm2 Rat arsenic atom affects methylation ISO MDM2 (Homo sapiens) 6480464 Arsenic affects the methylation of MDM2 gene CTD PMID:25304211 Mdm2 Rat arsenite(3-) multiple interactions ISO MDM2 (Homo sapiens) 6480464 [[[arsenite results in increased activity of PRKDC protein] which results in increased phosphorylation of and results in increased activity of MAPK9 protein] promotes the reaction [MAPK9 protein binds to TP53 protein]] inhibits the reaction [MDM2 results in increased degradation of and results in decreased stability of TP53 protein] more ... CTD PMID:22366412 more ... Mdm2 Rat arsenite(3-) increases expression ISO MDM2 (Homo sapiens) 6480464 arsenite results in increased expression of MDM2 mRNA more ... CTD PMID:30177839 and PMID:34425169 Mdm2 Rat arsenous acid decreases expression ISO MDM2 (Homo sapiens) 6480464 Arsenic Trioxide results in decreased expression of MDM2 mRNA CTD PMID:20458559 Mdm2 Rat arsenous acid multiple interactions EXP 6480464 pifithrin inhibits the reaction [Arsenic Trioxide results in increased expression of MDM2 mRNA] CTD PMID:17487067 Mdm2 Rat arsenous acid increases expression EXP 6480464 Arsenic Trioxide results in increased expression of MDM2 mRNA CTD PMID:17487067 Mdm2 Rat arsenous acid decreases expression EXP 6480464 Arsenic Trioxide results in decreased expression of MDM2 mRNA CTD PMID:21145380 Mdm2 Rat arsenous acid increases expression ISO MDM2 (Homo sapiens) 6480464 Arsenic Trioxide results in increased expression of MDM2 mRNA CTD PMID:20862710 more ... Mdm2 Rat aspartame multiple interactions ISO Mdm2 (Mus musculus) 6480464 [Fats and Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of MDM2 mRNA CTD PMID:23783067 Mdm2 Rat atorvastatin calcium increases expression ISO MDM2 (Homo sapiens) 6480464 Atorvastatin results in increased expression of MDM2 protein CTD PMID:29630879 Mdm2 Rat atrazine affects methylation EXP 6480464 Atrazine affects the methylation of MDM2 gene CTD PMID:28931070 and PMID:35440735 Mdm2 Rat avobenzone increases expression ISO MDM2 (Homo sapiens) 6480464 avobenzone results in increased expression of MDM2 mRNA CTD PMID:31016361 Mdm2 Rat azoxystrobin increases expression ISO MDM2 (Homo sapiens) 6480464 azoxystrobin results in increased expression of MDM2 protein CTD PMID:32339800 Mdm2 Rat benzene multiple interactions ISO Mdm2 (Mus musculus) 6480464 TRP53 protein affects the reaction [Benzene results in increased expression of MDM2 mRNA] CTD PMID:11896287 Mdm2 Rat benzene increases expression ISO Mdm2 (Mus musculus) 6480464 Benzene results in increased expression of MDM2 mRNA CTD PMID:11896287 more ... Mdm2 Rat benzene multiple interactions ISO MDM2 (Homo sapiens) 6480464 MDM2 gene polymorphism affects the reaction [CDKN2A gene polymorphism affects the susceptibility to Benzene] CTD PMID:19596022 Mdm2 Rat benzene multiple interactions EXP 6480464 [Benzene co-treated with methylmercury II co-treated with Trichloroethylene] results in increased expression of MDM2 mRNA CTD PMID:17905399 Mdm2 Rat benzo[a]pyrene increases expression ISO MDM2 (Homo sapiens) 6480464 Benzo(a)pyrene results in increased expression of MDM2 mRNA more ... CTD PMID:10837373 more ... Mdm2 Rat benzo[a]pyrene decreases expression ISO MDM2 (Homo sapiens) 6480464 Benzo(a)pyrene results in decreased expression of MDM2 mRNA CTD PMID:30562542 Mdm2 Rat benzo[a]pyrene multiple interactions ISO Mdm2 (Mus musculus) 6480464 [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of MDM2 mRNA CTD PMID:27858113 Mdm2 Rat benzo[a]pyrene increases phosphorylation ISO MDM2 (Homo sapiens) 6480464 Benzo(a)pyrene results in increased phosphorylation of MDM2 protein CTD PMID:20840854 and PMID:25744307 Mdm2 Rat benzo[a]pyrene increases expression ISO Mdm2 (Mus musculus) 6480464 Benzo(a)pyrene metabolite results in increased expression of MDM2 mRNA and Benzo(a)pyrene results in increased expression of MDM2 mRNA CTD PMID:18656336 more ... Mdm2 Rat benzo[a]pyrene decreases expression EXP 6480464 Benzo(a)pyrene results in decreased expression of MDM2 protein CTD PMID:21467743 Mdm2 Rat benzo[a]pyrene multiple interactions ISO MDM2 (Homo sapiens) 6480464 2 more ... CTD PMID:10837373 more ... Mdm2 Rat benzo[a]pyrene diol epoxide I increases expression ISO MDM2 (Homo sapiens) 6480464 7 more ... CTD PMID:20382639 more ... Mdm2 Rat benzo[b]fluoranthene increases expression ISO Mdm2 (Mus musculus) 6480464 benzo(b)fluoranthene results in increased expression of MDM2 mRNA CTD PMID:26377693 Mdm2 Rat benzo[b]fluoranthene multiple interactions ISO Mdm2 (Mus musculus) 6480464 [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of MDM2 mRNA CTD PMID:27858113 Mdm2 Rat beta-naphthoflavone increases phosphorylation EXP 6480464 beta-Naphthoflavone results in increased phosphorylation of MDM2 protein CTD PMID:26558467 Mdm2 Rat biphenyl-4-amine increases expression ISO MDM2 (Homo sapiens) 6480464 4-biphenylamine results in increased expression of MDM2 mRNA CTD PMID:32905825 Mdm2 Rat biphenyl-4-amine multiple interactions ISO MDM2 (Homo sapiens) 6480464 TP53 protein inhibits the reaction [4-biphenylamine results in increased expression of MDM2 mRNA] CTD PMID:32905825 Mdm2 Rat bis(2-chloroethyl) sulfide affects expression EXP 6480464 Mustard Gas affects the expression of MDM2 mRNA CTD PMID:15651846 Mdm2 Rat bis(2-chloroethyl) sulfide increases expression ISO MDM2 (Homo sapiens) 6480464 Mustard Gas results in increased expression of MDM2 mRNA CTD PMID:33491125 Mdm2 Rat bis(2-chloroethyl) sulfide increases expression ISO Mdm2 (Mus musculus) 6480464 Mustard Gas results in increased expression of MDM2 mRNA CTD PMID:15674843 and PMID:18955075 Mdm2 Rat bis(2-ethylhexyl) phthalate increases expression ISO MDM2 (Homo sapiens) 6480464 Diethylhexyl Phthalate results in increased expression of MDM2 mRNA CTD PMID:31163220 Mdm2 Rat bis(2-ethylhexyl) phthalate decreases phosphorylation ISO MDM2 (Homo sapiens) 6480464 Diethylhexyl Phthalate results in decreased phosphorylation of MDM2 protein CTD PMID:31163220 Mdm2 Rat bisphenol A increases expression ISO Mdm2 (Mus musculus) 6480464 bisphenol A results in increased expression of MDM2 mRNA CTD PMID:26063408 Mdm2 Rat bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of MDM2 mRNA CTD PMID:30816183 more ... Mdm2 Rat bisphenol A increases expression ISO MDM2 (Homo sapiens) 6480464 bisphenol A analog results in increased expression of MDM2 mRNA and bisphenol A results in increased expression of MDM2 mRNA CTD PMID:29275510 and PMID:32387340 Mdm2 Rat bisphenol A affects expression ISO MDM2 (Homo sapiens) 6480464 bisphenol A affects the expression of MDM2 mRNA CTD PMID:30903817 Mdm2 Rat bisphenol A multiple interactions ISO MDM2 (Homo sapiens) 6480464 [naringenin co-treated with bisphenol A] results in increased expression of MDM2 mRNA more ... CTD PMID:24831732 and PMID:36235125 Mdm2 Rat bisphenol A increases phosphorylation ISO MDM2 (Homo sapiens) 6480464 bisphenol A results in increased phosphorylation of MDM2 protein CTD PMID:24831732 Mdm2 Rat bisphenol A affects expression EXP 6480464 bisphenol A affects the expression of MDM2 mRNA CTD PMID:25181051 Mdm2 Rat bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of MDM2 mRNA CTD PMID:26982218 Mdm2 Rat bisphenol F increases expression ISO Mdm2 (Mus musculus) 6480464 bisphenol F results in increased expression of MDM2 mRNA CTD PMID:35387338 Mdm2 Rat bortezomib multiple interactions ISO MDM2 (Homo sapiens) 6480464 [CASP8 protein results in increased activity of CASP3 protein] affects the reaction [Bortezomib results in increased cleavage of MDM2 protein] and Bortezomib promotes the reaction [TP53 protein binds to MDM2 protein] CTD PMID:12393500 Mdm2 Rat bortezomib increases cleavage ISO MDM2 (Homo sapiens) 6480464 Bortezomib results in increased cleavage of MDM2 protein CTD PMID:12393500 Mdm2 Rat bortezomib affects expression ISO MDM2 (Homo sapiens) 6480464 Bortezomib affects the expression of MDM2 protein CTD PMID:12393500 Mdm2 Rat brassinolide decreases expression ISO MDM2 (Homo sapiens) 6480464 brassinolide results in decreased expression of MDM2 protein CTD PMID:20833159 Mdm2 Rat cadmium atom decreases expression EXP 6480464 Cadmium results in decreased expression of MDM2 mRNA CTD PMID:21467746 Mdm2 Rat cadmium atom increases expression ISO Mdm2 (Mus musculus) 6480464 Cadmium results in increased expression of MDM2 mRNA CTD PMID:22666406 Mdm2 Rat cadmium dichloride affects expression EXP 6480464 Cadmium Chloride affects the expression of MDM2 mRNA CTD PMID:22110744 Mdm2 Rat cadmium dichloride decreases expression ISO MDM2 (Homo sapiens) 6480464 Cadmium Chloride results in decreased expression of MDM2 mRNA CTD PMID:38568856 Mdm2 Rat cadmium dichloride decreases expression EXP 6480464 Cadmium Chloride results in decreased expression of MDM2 mRNA CTD PMID:31077537 Mdm2 Rat cadmium dichloride multiple interactions EXP 6480464 [Cadmium Chloride co-treated with diallyl disulfide] results in decreased expression of MDM2 mRNA CTD PMID:31077537 Mdm2 Rat cadmium dichloride increases expression EXP 6480464 Cadmium Chloride results in increased expression of MDM2 mRNA CTD PMID:23405080 Mdm2 Rat cadmium dichloride multiple interactions ISO MDM2 (Homo sapiens) 6480464 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MDM2 protein] more ... CTD PMID:25744307 Mdm2 Rat cadmium dichloride increases phosphorylation ISO MDM2 (Homo sapiens) 6480464 Cadmium Chloride results in increased phosphorylation of MDM2 protein CTD PMID:25744307 Mdm2 Rat cadmium dichloride increases expression ISO Mdm2 (Mus musculus) 6480464 Cadmium Chloride results in increased expression of MDM2 mRNA CTD PMID:11958953 more ... Mdm2 Rat cadmium dichloride increases phosphorylation ISO Mdm2 (Mus musculus) 6480464 Cadmium Chloride results in increased phosphorylation of MDM2 protein CTD PMID:20525538 and PMID:22314386 Mdm2 Rat cadmium dichloride multiple interactions ISO Mdm2 (Mus musculus) 6480464 Cadmium Chloride promotes the reaction [Methylnitronitrosoguanidine results in increased expression of MDM2 protein] more ... CTD PMID:11958953 and PMID:12135628 Mdm2 Rat caffeine decreases phosphorylation ISO MDM2 (Homo sapiens) 6480464 Caffeine results in decreased phosphorylation of MDM2 protein CTD PMID:35688186 Mdm2 Rat camptothecin increases expression ISO MDM2 (Homo sapiens) 6480464 Camptothecin results in increased expression of MDM2 protein CTD PMID:17555331 Mdm2 Rat cannabidiol multiple interactions ISO Mdm2 (Mus musculus) 6480464 [lipopolysaccharide and E coli O55-B5 co-treated with Cannabidiol] results in increased expression of MDM2 mRNA CTD PMID:30742662 Mdm2 Rat cannabidiol increases expression ISO MDM2 (Homo sapiens) 6480464 Cannabidiol results in increased expression of MDM2 mRNA CTD PMID:27932991 and PMID:30713602 Mdm2 Rat cannabidiol increases expression ISO Mdm2 (Mus musculus) 6480464 Cannabidiol results in increased expression of MDM2 mRNA CTD PMID:30742662 Mdm2 Rat cantharidin decreases expression ISO MDM2 (Homo sapiens) 6480464 Cantharidin results in decreased expression of MDM2 mRNA CTD PMID:31945315 Mdm2 Rat capsaicin multiple interactions ISO MDM2 (Homo sapiens) 6480464 Capsaicin promotes the reaction [resveratrol results in decreased expression of MDM2 protein] more ... CTD PMID:19846903 Mdm2 Rat capsaicin increases expression ISO MDM2 (Homo sapiens) 6480464 Capsaicin results in increased expression of MDM2 mRNA CTD PMID:19502594 Mdm2 Rat capsaicin decreases expression ISO MDM2 (Homo sapiens) 6480464 Capsaicin results in decreased expression of MDM2 protein CTD PMID:19846903 Mdm2 Rat Carbadox increases expression EXP 6480464 Carbadox results in increased expression of MDM2 mRNA CTD PMID:26558467 Mdm2 Rat carbamazepine affects expression ISO MDM2 (Homo sapiens) 6480464 Carbamazepine affects the expression of MDM2 mRNA CTD PMID:25979313 Mdm2 Rat carbonyl cyanide p-trifluoromethoxyphenylhydrazone decreases expression ISO MDM2 (Homo sapiens) 6480464 Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in decreased expression of MDM2 mRNA CTD PMID:16039398 Mdm2 Rat chlorambucil increases expression ISO MDM2 (Homo sapiens) 6480464 Chlorambucil results in increased expression of MDM2 mRNA CTD PMID:17476690 Mdm2 Rat chloroacetaldehyde increases expression ISO MDM2 (Homo sapiens) 6480464 chloroacetaldehyde results in increased expression of MDM2 mRNA CTD PMID:25596134 Mdm2 Rat chloroethene affects response to substance ISO MDM2 (Homo sapiens) 6480464 MDM2 polymorphism affects the susceptibility to Vinyl Chloride CTD PMID:24464562 Mdm2 Rat chloroprene increases expression ISO Mdm2 (Mus musculus) 6480464 Chloroprene results in increased expression of MDM2 mRNA CTD PMID:23125180 Mdm2 Rat chlorpromazine increases expression EXP 6480464 Chlorpromazine results in increased expression of MDM2 mRNA CTD PMID:25596134 Mdm2 Rat chlorpyrifos increases expression ISO MDM2 (Homo sapiens) 6480464 Chlorpyrifos results in increased expression of MDM2 mRNA CTD PMID:30981936 Mdm2 Rat chlorpyrifos decreases expression ISO Mdm2 (Mus musculus) 6480464 Chlorpyrifos results in decreased expression of MDM2 mRNA CTD PMID:37019170 Mdm2 Rat choline multiple interactions ISO Mdm2 (Mus musculus) 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of MDM2 gene CTD PMID:20938992 Mdm2 Rat chrysene multiple interactions ISO Mdm2 (Mus musculus) 6480464 [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of MDM2 mRNA CTD PMID:27858113 Mdm2 Rat cidofovir anhydrous affects expression ISO MDM2 (Homo sapiens) 6480464 Cidofovir affects the expression of MDM2 mRNA CTD PMID:25596134 Mdm2 Rat cisplatin increases expression EXP 6480464 Cisplatin results in increased expression of MDM2 mRNA CTD PMID:24880025 Mdm2 Rat cisplatin decreases expression EXP 6480464 Cisplatin results in decreased expression of MDM2 mRNA and Cisplatin results in decreased expression of MDM2 protein CTD PMID:35842499 Mdm2 Rat cisplatin multiple interactions EXP 6480464 Cisplatin promotes the reaction [NFE2L2 protein results in increased expression of MDM2 mRNA] more ... CTD PMID:35842499 Mdm2 Rat cisplatin increases expression ISO Mdm2 (Mus musculus) 6480464 Cisplatin results in increased expression of MDM2 mRNA and Cisplatin results in increased expression of MDM2 protein CTD PMID:21151649 more ... Mdm2 Rat cisplatin multiple interactions ISO Mdm2 (Mus musculus) 6480464 Cisplatin promotes the reaction [TRP53 protein results in increased expression of MDM2] more ... CTD PMID:21552291 more ... Mdm2 Rat cisplatin increases expression ISO MDM2 (Homo sapiens) 6480464 Cisplatin results in increased expression of MDM2 mRNA and Cisplatin results in increased expression of MDM2 protein CTD PMID:16797627 more ... Mdm2 Rat cisplatin multiple interactions ISO MDM2 (Homo sapiens) 6480464 [Cisplatin co-treated with eprenetapopt co-treated with Oxygen deficiency] results in increased expression of MDM2 mRNA more ... CTD PMID:21509038 more ... Mdm2 Rat clofibrate multiple interactions ISO Mdm2 (Mus musculus) 6480464 [Clofibrate co-treated with Acetaminophen] affects the expression of MDM2 mRNA and PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of MDM2 mRNA] CTD PMID:17585979 Mdm2 Rat cobalt atom increases expression ISO MDM2 (Homo sapiens) 6480464 Cobalt results in increased expression of MDM2 mRNA CTD PMID:24068677 Mdm2 Rat cobalt atom multiple interactions ISO MDM2 (Homo sapiens) 6480464 TP53 protein affects the reaction [Cobalt results in increased expression of MDM2 mRNA] CTD PMID:24068677 Mdm2 Rat cobalt dichloride increases expression ISO MDM2 (Homo sapiens) 6480464 cobaltous chloride results in increased expression of MDM2 protein CTD PMID:19714248 Mdm2 Rat cobalt dichloride increases expression EXP 6480464 cobaltous chloride results in increased expression of MDM2 mRNA CTD PMID:24386269 Mdm2 Rat cobalt dichloride multiple interactions ISO MDM2 (Homo sapiens) 6480464 MDM2 protein promotes the reaction [cobaltous chloride inhibits the reaction [HIPK2 protein promotes the reaction [Doxorubicin results in increased phosphorylation of and results in increased activity of TP53 protein]]] CTD PMID:19714248 Mdm2 Rat copper atom increases expression ISO Mdm2 (Mus musculus) 6480464 Copper results in increased expression of MDM2 mRNA CTD PMID:16629173 Mdm2 Rat copper atom multiple interactions ISO MDM2 (Homo sapiens) 6480464 [Chelating Agents binds to Copper] which results in increased expression of MDM2 mRNA CTD PMID:30911355 Mdm2 Rat copper(0) increases expression ISO Mdm2 (Mus musculus) 6480464 Copper results in increased expression of MDM2 mRNA CTD PMID:16629173 Mdm2 Rat copper(0) multiple interactions ISO MDM2 (Homo sapiens) 6480464 [Chelating Agents binds to Copper] which results in increased expression of MDM2 mRNA CTD PMID:30911355 Mdm2 Rat corn oil decreases expression EXP 6480464 Corn Oil results in decreased expression of MDM2 mRNA CTD PMID:22760963 Mdm2 Rat coumarin decreases expression ISO MDM2 (Homo sapiens) 6480464 coumarin analog results in decreased expression of MDM2 mRNA CTD PMID:32578917 Mdm2 Rat crocidolite asbestos decreases expression ISO Mdm2 (Mus musculus) 6480464 Asbestos and Crocidolite results in decreased expression of MDM2 mRNA CTD PMID:29279043 Mdm2 Rat cryptolepine increases expression ISO MDM2 (Homo sapiens) 6480464 cryptolepine results in increased expression of MDM2 mRNA and cryptolepine results in increased expression of MDM2 protein CTD PMID:16120219 Mdm2 Rat curcumin decreases expression ISO MDM2 (Homo sapiens) 6480464 [Curcumin results in decreased expression of MDM2 protein] which results in decreased expression of CDKN1A mRNA more ... CTD PMID:17332326 Mdm2 Rat curcumin increases expression ISO MDM2 (Homo sapiens) 6480464 Curcumin analog results in increased expression of MDM2 mRNA CTD PMID:26409325 Mdm2 Rat curcumin multiple interactions ISO MDM2 (Homo sapiens) 6480464 Curcumin inhibits the reaction [bisphenol A results in increased phosphorylation of MDM2 protein] CTD PMID:24831732 Mdm2 Rat cyclosporin A increases expression ISO MDM2 (Homo sapiens) 6480464 Cyclosporine results in increased expression of MDM2 mRNA CTD PMID:20106945 more ... Mdm2 Rat cylindrospermopsin increases expression ISO MDM2 (Homo sapiens) 6480464 cylindrospermopsin results in increased expression of MDM2 mRNA CTD PMID:21607682 Mdm2 Rat cylindrospermopsin multiple interactions ISO MDM2 (Homo sapiens) 6480464 [4 and 4'-hexafluorisopropylidene diphenol co-treated with cylindrospermopsin] results in increased expression of MDM2 mRNA CTD PMID:32244372 Mdm2 Rat cyproconazole multiple interactions EXP 6480464 [cyproconazole co-treated with epoxiconazole co-treated with prochloraz] results in increased expression of MDM2 mRNA and [cyproconazole co-treated with epoxiconazole] results in increased expression of MDM2 mRNA CTD PMID:29038839 Mdm2 Rat DAPT increases expression ISO MDM2 (Homo sapiens) 6480464 N-(N-(3 and 5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester results in increased expression of MDM2 protein CTD PMID:25005833 Mdm2 Rat DAPT multiple interactions ISO MDM2 (Homo sapiens) 6480464 Hydrogen Peroxide inhibits the reaction [N-(N-(3 and 5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester results in increased expression of MDM2 protein] CTD PMID:25005833 Mdm2 Rat DDT multiple interactions ISO Mdm2 (Mus musculus) 6480464 Androstanols inhibits the reaction [DDT results in increased expression of MDM2 mRNA] CTD PMID:23684557 Mdm2 Rat DDT increases expression ISO Mdm2 (Mus musculus) 6480464 DDT results in increased expression of MDM2 mRNA and DDT results in increased expression of MDM2 protein CTD PMID:23684557 Mdm2 Rat deguelin increases expression ISO MDM2 (Homo sapiens) 6480464 deguelin results in increased expression of MDM2 mRNA CTD PMID:33512557 Mdm2 Rat DENSPM multiple interactions ISO MDM2 (Homo sapiens) 6480464 Fluorouracil promotes the reaction [N(1) more ... CTD PMID:15546879 Mdm2 Rat DENSPM increases expression ISO MDM2 (Homo sapiens) 6480464 N(1) and N(11)-diethylnorspermine results in increased expression of MDM2 protein CTD PMID:15546879 Mdm2 Rat deoxynivalenol increases expression ISO MDM2 (Homo sapiens) 6480464 deoxynivalenol results in increased expression of MDM2 mRNA CTD PMID:31863870 Mdm2 Rat desferrioxamine B increases expression EXP 6480464 Deferoxamine results in increased expression of MDM2 protein CTD PMID:19950214 Mdm2 Rat diallyl disulfide multiple interactions EXP 6480464 [Cadmium Chloride co-treated with diallyl disulfide] results in decreased expression of MDM2 mRNA CTD PMID:31077537 Mdm2 Rat diallyl trisulfide decreases expression ISO MDM2 (Homo sapiens) 6480464 diallyl trisulfide results in decreased expression of MDM2 protein CTD PMID:24415872 Mdm2 Rat diallyl trisulfide increases degradation ISO MDM2 (Homo sapiens) 6480464 diallyl trisulfide results in increased degradation of MDM2 protein CTD PMID:23754639 Mdm2 Rat diarsenic trioxide multiple interactions EXP 6480464 pifithrin inhibits the reaction [Arsenic Trioxide results in increased expression of MDM2 mRNA] CTD PMID:17487067 Mdm2 Rat diarsenic trioxide decreases expression EXP 6480464 Arsenic Trioxide results in decreased expression of MDM2 mRNA CTD PMID:21145380 Mdm2 Rat diarsenic trioxide increases expression EXP 6480464 Arsenic Trioxide results in increased expression of MDM2 mRNA CTD PMID:17487067 Mdm2 Rat diarsenic trioxide decreases expression ISO MDM2 (Homo sapiens) 6480464 Arsenic Trioxide results in decreased expression of MDM2 mRNA CTD PMID:20458559 Mdm2 Rat diarsenic trioxide increases expression ISO MDM2 (Homo sapiens) 6480464 Arsenic Trioxide results in increased expression of MDM2 mRNA CTD PMID:20862710 more ... Mdm2 Rat diazinon affects expression EXP 6480464 Diazinon affects the expression of MDM2 mRNA CTD PMID:22546817 Mdm2 Rat dibenz[a,h]anthracene increases expression ISO Mdm2 (Mus musculus) 6480464 1 more ... CTD PMID:26377693 Mdm2 Rat diclofenac decreases expression EXP 6480464 Diclofenac results in decreased expression of MDM2 mRNA CTD PMID:17202759 Mdm2 Rat dieldrin affects expression EXP 6480464 Dieldrin affects the expression of MDM2 mRNA CTD PMID:22546817 Mdm2 Rat dieldrin affects methylation ISO Mdm2 (Mus musculus) 6480464 Dieldrin affects the methylation of MDM2 gene CTD PMID:38995845 Mdm2 Rat diepoxybutane multiple interactions ISO MDM2 (Homo sapiens) 6480464 diepoxybutane inhibits the reaction [TP53 protein binds to MDM2 protein] CTD PMID:20024960 Mdm2 Rat diethylstilbestrol affects mutagenesis ISO Mdm2 (Mus musculus) 6480464 Diethylstilbestrol affects the mutagenesis of MDM2 gene CTD PMID:7916985 Mdm2 Rat diethylstilbestrol decreases expression ISO Mdm2 (Mus musculus) 6480464 Diethylstilbestrol results in decreased expression of MDM2 mRNA CTD PMID:21041162 Mdm2 Rat diethylstilbestrol increases expression EXP 6480464 Diethylstilbestrol results in increased expression of MDM2 mRNA CTD PMID:15890375 Mdm2 Rat diethylstilbestrol increases expression ISO Mdm2 (Mus musculus) 6480464 Diethylstilbestrol results in increased expression of MDM2 mRNA CTD PMID:15545218 Mdm2 Rat dimethylarsinic acid increases expression EXP 6480464 Cacodylic Acid results in increased expression of MDM2 mRNA CTD PMID:17481689 Mdm2 Rat dimethylarsinic acid multiple interactions ISO MDM2 (Homo sapiens) 6480464 [sodium arsenite co-treated with monomethylarsonic acid co-treated with Cacodylic Acid] affects the expression of MDM2 mRNA CTD PMID:23192986 Mdm2 Rat dioxygen multiple interactions ISO MDM2 (Homo sapiens) 6480464 [Cisplatin co-treated with eprenetapopt co-treated with Oxygen deficiency] results in increased expression of MDM2 mRNA more ... CTD PMID:19578757 and PMID:29690507 Mdm2 Rat dioxygen multiple interactions ISO Mdm2 (Mus musculus) 6480464 [NFE2L2 protein affects the susceptibility to Oxygen] which affects the expression of MDM2 mRNA CTD PMID:30529165 Mdm2 Rat dioxygen increases expression ISO MDM2 (Homo sapiens) 6480464 Oxygen deficiency results in increased expression of MDM2 mRNA and Oxygen deficiency results in increased expression of MDM2 protein CTD PMID:19502547 more ... Mdm2 Rat disodium selenite increases expression ISO MDM2 (Homo sapiens) 6480464 Sodium Selenite results in increased expression of MDM2 mRNA CTD PMID:24383545 Mdm2 Rat dorsomorphin multiple interactions ISO MDM2 (Homo sapiens) 6480464 [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 Mdm2 Rat doxorubicin multiple interactions ISO MDM2 (Homo sapiens) 6480464 Doxorubicin inhibits the reaction [TP53 protein binds to MDM2 protein] more ... CTD PMID:17935137 more ... Mdm2 Rat doxorubicin affects expression ISO Mdm2 (Mus musculus) 6480464 Doxorubicin affects the expression of MDM2 mRNA CTD PMID:29653124 Mdm2 Rat doxorubicin increases expression EXP 6480464 Doxorubicin results in increased expression of MDM2 mRNA CTD PMID:12187937 more ... Mdm2 Rat doxorubicin increases expression ISO MDM2 (Homo sapiens) 6480464 Doxorubicin results in increased expression of MDM2 mRNA and Doxorubicin results in increased expression of MDM2 protein CTD PMID:14665630 more ... Mdm2 Rat doxorubicin decreases response to substance ISO MDM2 (Homo sapiens) 6480464 MDM2 protein results in decreased susceptibility to Doxorubicin CTD PMID:26317544 Mdm2 Rat doxorubicin affects expression ISO MDM2 (Homo sapiens) 6480464 Doxorubicin affects the expression of MDM2 mRNA CTD PMID:25529476 and PMID:29803840 Mdm2 Rat doxorubicin increases expression ISO Mdm2 (Mus musculus) 6480464 Doxorubicin results in increased expression of MDM2 mRNA CTD PMID:14766674 more ... Mdm2 Rat doxorubicin multiple interactions ISO Mdm2 (Mus musculus) 6480464 pifithrin inhibits the reaction [Doxorubicin results in increased expression of MDM2 mRNA] CTD PMID:14766674 Mdm2 Rat doxorubicin increases phosphorylation ISO MDM2 (Homo sapiens) 6480464 Doxorubicin results in increased phosphorylation of MDM2 protein CTD PMID:17935137 Mdm2 Rat eflornithine decreases expression EXP 6480464 Eflornithine results in decreased expression of MDM2 mRNA CTD PMID:11502571 Mdm2 Rat ellipticine decreases response to substance ISO MDM2 (Homo sapiens) 6480464 MDM2 promoter SNP results in decreased susceptibility to ellipticine CTD PMID:17575151 Mdm2 Rat endosulfan increases expression EXP 6480464 Endosulfan results in increased expression of MDM2 mRNA CTD PMID:29391264 Mdm2 Rat epoxiconazole increases expression EXP 6480464 epoxiconazole results in increased expression of MDM2 mRNA CTD PMID:29038839 Mdm2 Rat epoxiconazole multiple interactions EXP 6480464 [cyproconazole co-treated with epoxiconazole co-treated with prochloraz] results in increased expression of MDM2 mRNA and [cyproconazole co-treated with epoxiconazole] results in increased expression of MDM2 mRNA CTD PMID:29038839 Mdm2 Rat ethanol decreases expression ISO Mdm2 (Mus musculus) 6480464 Ethanol results in decreased expression of MDM2 mRNA CTD PMID:22535522 Mdm2 Rat ethyl methanesulfonate increases expression ISO MDM2 (Homo sapiens) 6480464 Ethyl Methanesulfonate results in increased expression of MDM2 mRNA CTD PMID:23649840 Mdm2 Rat etoposide increases expression ISO MDM2 (Homo sapiens) 6480464 Etoposide results in increased expression of MDM2 mRNA more ... CTD PMID:16120219 more ... Mdm2 Rat etoposide decreases expression ISO MDM2 (Homo sapiens) 6480464 Etoposide results in decreased expression of MDM2 protein CTD PMID:26259609 Mdm2 Rat etoposide increases phosphorylation ISO MDM2 (Homo sapiens) 6480464 Etoposide results in increased phosphorylation of MDM2 protein CTD PMID:17935137 and PMID:25744307 Mdm2 Rat etoposide increases expression EXP 6480464 Etoposide results in increased expression of MDM2 protein CTD PMID:15459018 Mdm2 Rat etoposide multiple interactions EXP 6480464 Tetrachlorodibenzodioxin inhibits the reaction [Etoposide results in increased expression of MDM2 protein] CTD PMID:15459018 Mdm2 Rat etoposide decreases response to substance ISO MDM2 (Homo sapiens) 6480464 MDM2 promoter SNP results in decreased susceptibility to Etoposide CTD PMID:17575151 Mdm2 Rat etoposide multiple interactions ISO MDM2 (Homo sapiens) 6480464 benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [Etoposide promotes the reaction [MDM2 protein binds to TOP2A protein]] more ... CTD PMID:17575151 more ... Mdm2 Rat EUK-134 multiple interactions ISO MDM2 (Homo sapiens) 6480464 EUK-134 inhibits the reaction [Hydrogen Peroxide results in decreased expression of MDM2 protein] and EUK-134 inhibits the reaction [Vitamin K 3 results in decreased expression of MDM2 protein] CTD PMID:25005833 Mdm2 Rat fenbendazole increases expression EXP 6480464 Fenbendazole results in increased expression of MDM2 mRNA CTD PMID:23411599 Mdm2 Rat fenofibrate decreases expression EXP 6480464 Fenofibrate results in decreased expression of MDM2 mRNA CTD PMID:25596134 Mdm2 Rat fipronil increases expression EXP 6480464 fipronil results in increased expression of MDM2 mRNA CTD PMID:23962444 Mdm2 Rat flavanones increases phosphorylation ISO MDM2 (Homo sapiens) 6480464 Flavanones results in increased phosphorylation of MDM2 protein CTD PMID:21616090 Mdm2 Rat flucytosine increases expression ISO MDM2 (Homo sapiens) 6480464 Flucytosine results in increased expression of MDM2 protein CTD PMID:15592511 Mdm2 Rat fluoranthene multiple interactions ISO MDM2 (Homo sapiens) 6480464 [Benzo(a)pyrene co-treated with fluoranthene] affects the expression of MDM2 mRNA CTD PMID:17690111 Mdm2 Rat flutamide increases expression EXP 6480464 Flutamide results in increased expression of MDM2 mRNA CTD PMID:24136188 Mdm2 Rat folic acid affects expression ISO MDM2 (Homo sapiens) 6480464 Folic Acid affects the expression of MDM2 mRNA CTD PMID:16361273 Mdm2 Rat folic acid multiple interactions ISO Mdm2 (Mus musculus) 6480464 [1 more ... CTD PMID:20938992 and PMID:22206623 Mdm2 Rat formaldehyde increases expression EXP 6480464 Formaldehyde results in increased expression of MDM2 mRNA and Formaldehyde results in increased expression of MDM2 protein CTD PMID:18045764 Mdm2 Rat formaldehyde increases expression ISO MDM2 (Homo sapiens) 6480464 Formaldehyde results in increased expression of MDM2 mRNA and Formaldehyde results in increased expression of MDM2 protein CTD PMID:18045764 and PMID:23649840 Mdm2 Rat formononetin increases expression EXP 6480464 formononetin results in increased expression of MDM2 protein CTD PMID:28414026 Mdm2 Rat FR900359 decreases phosphorylation ISO MDM2 (Homo sapiens) 6480464 FR900359 results in decreased phosphorylation of MDM2 protein CTD PMID:37730182 Mdm2 Rat fumonisin B1 multiple interactions ISO MDM2 (Homo sapiens) 6480464 fumonisin B1 inhibits the reaction [AGT protein results in increased expression of MDM2 mRNA] and fumonisin B1 inhibits the reaction [AGT protein results in increased expression of MDM2 protein] CTD PMID:18206046 Mdm2 Rat furan increases expression EXP 6480464 furan results in increased expression of MDM2 mRNA CTD PMID:22079235 Mdm2 Rat furosemide affects expression EXP 6480464 Furosemide affects the expression of MDM2 mRNA CTD PMID:17497460 Mdm2 Rat ganciclovir increases expression ISO MDM2 (Homo sapiens) 6480464 Ganciclovir results in increased expression of MDM2 protein CTD PMID:15592511 Mdm2 Rat geldanamycin increases expression ISO MDM2 (Homo sapiens) 6480464 geldanamycin results in increased expression of MDM2 mRNA CTD PMID:26705709 Mdm2 Rat gemcitabine increases expression ISO MDM2 (Homo sapiens) 6480464 Gemcitabine results in increased expression of MDM2 mRNA CTD PMID:17039268 Mdm2 Rat gemcitabine decreases expression ISO MDM2 (Homo sapiens) 6480464 Gemcitabine results in decreased expression of MDM2 mRNA CTD PMID:20103597 Mdm2 Rat genistein decreases expression ISO Mdm2 (Mus musculus) 6480464 Genistein results in decreased expression of MDM2 mRNA CTD PMID:21048042 Mdm2 Rat gentamycin increases expression EXP 6480464 Gentamicins results in increased expression of MDM2 mRNA CTD PMID:22061828 and PMID:33387578 Mdm2 Rat glyphosate decreases expression ISO MDM2 (Homo sapiens) 6480464 Glyphosate results in decreased expression of MDM2 mRNA CTD PMID:31295307 Mdm2 Rat gold atom decreases expression ISO MDM2 (Homo sapiens) 6480464 Gold analog results in decreased expression of MDM2 mRNA CTD PMID:36057382 Mdm2 Rat gold(0) decreases expression ISO MDM2 (Homo sapiens) 6480464 Gold analog results in decreased expression of MDM2 mRNA CTD PMID:36057382 Mdm2 Rat GW 501516 multiple interactions EXP 6480464 MDM2 protein inhibits the reaction [GW 501516 results in increased activity of PPARB protein] CTD PMID:19103650 Mdm2 Rat hydrogen peroxide multiple interactions ISO MDM2 (Homo sapiens) 6480464 EUK-134 inhibits the reaction [Hydrogen Peroxide results in decreased expression of MDM2 protein] more ... CTD PMID:21552291 and PMID:25005833 Mdm2 Rat hydrogen peroxide increases expression ISO MDM2 (Homo sapiens) 6480464 Hydrogen Peroxide results in increased expression of MDM2 mRNA CTD PMID:21751221 Mdm2 Rat hydrogen peroxide increases expression EXP 6480464 Hydrogen Peroxide results in increased expression of MDM2 mRNA CTD PMID:14689451 and PMID:27525270 Mdm2 Rat hydrogen peroxide multiple interactions EXP 6480464 [Quercetin co-treated with Hydrogen Peroxide] results in increased expression of MDM2 mRNA more ... CTD PMID:14689451 and PMID:27525270 Mdm2 Rat hydrogen peroxide decreases expression ISO MDM2 (Homo sapiens) 6480464 Hydrogen Peroxide results in decreased expression of MDM2 protein CTD PMID:25005833 Mdm2 Rat hydrogen peroxide multiple interactions ISO Mdm2 (Mus musculus) 6480464 Hydrogen Peroxide promotes the reaction [TRP53 protein results in increased expression of MDM2] CTD PMID:21552291 Mdm2 Rat hydroquinone increases expression ISO MDM2 (Homo sapiens) 6480464 hydroquinone results in increased expression of MDM2 mRNA CTD PMID:29221148 Mdm2 Rat hydroxyurea increases expression ISO MDM2 (Homo sapiens) 6480464 Hydroxyurea results in increased expression of MDM2 mRNA CTD PMID:18647660 Mdm2 Rat hydroxyurea increases expression ISO Mdm2 (Mus musculus) 6480464 Hydroxyurea results in increased expression of MDM2 mRNA CTD PMID:16356682 Mdm2 Rat hydroxyurea affects expression ISO Mdm2 (Mus musculus) 6480464 Hydroxyurea affects the expression of MDM2 protein CTD PMID:16356682 Mdm2 Rat Icaritin decreases expression ISO MDM2 (Homo sapiens) 6480464 icaritin results in decreased expression of MDM2 protein CTD PMID:38431053 Mdm2 Rat ifosfamide increases expression ISO MDM2 (Homo sapiens) 6480464 Ifosfamide results in increased expression of MDM2 mRNA CTD PMID:25596134 Mdm2 Rat Indeno[1,2,3-cd]pyrene increases expression ISO MDM2 (Homo sapiens) 6480464 indeno(1 more ... CTD PMID:32251684 Mdm2 Rat irinotecan increases expression ISO MDM2 (Homo sapiens) 6480464 Irinotecan metabolite results in increased expression of MDM2 mRNA and Irinotecan results in increased expression of MDM2 mRNA CTD PMID:15956246 Mdm2 Rat isoflurane decreases expression EXP 6480464 Isoflurane results in decreased expression of MDM2 mRNA CTD PMID:16978161 Mdm2 Rat kojic acid multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of MDM2 mRNA CTD PMID:18544905 Mdm2 Rat L-ascorbic acid multiple interactions EXP 6480464 Ascorbic Acid inhibits the reaction [Potassium Dichromate results in decreased expression of MDM2 protein] CTD PMID:21262251 Mdm2 Rat L-methionine multiple interactions ISO Mdm2 (Mus musculus) 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of MDM2 gene CTD PMID:20938992 Mdm2 Rat leflunomide increases expression ISO MDM2 (Homo sapiens) 6480464 leflunomide results in increased expression of MDM2 mRNA CTD PMID:28988120 Mdm2 Rat leptomycin B increases expression ISO MDM2 (Homo sapiens) 6480464 leptomycin B results in increased expression of MDM2 mRNA CTD PMID:20803015 Mdm2 Rat Leucomalachite green increases phosphorylation EXP 6480464 leucomalachite green results in increased phosphorylation of MDM2 protein CTD PMID:26558467 Mdm2 Rat linalool increases expression ISO MDM2 (Homo sapiens) 6480464 linalool results in increased expression of MDM2 mRNA CTD PMID:19922762 Mdm2 Rat lipopolysaccharide multiple interactions ISO Mdm2 (Mus musculus) 6480464 Indirubin E804 inhibits the reaction [Lipopolysaccharides results in increased expression of MDM2 mRNA] CTD PMID:23107598 Mdm2 Rat lipopolysaccharide increases expression ISO MDM2 (Homo sapiens) 6480464 Lipopolysaccharides results in increased expression of MDM2 mRNA CTD PMID:35953652 Mdm2 Rat lipopolysaccharide increases expression ISO Mdm2 (Mus musculus) 6480464 Lipopolysaccharides results in increased expression of MDM2 mRNA CTD PMID:10975854 and PMID:23107598 Mdm2 Rat lupeol multiple interactions ISO MDM2 (Homo sapiens) 6480464 lupeol inhibits the reaction [mancozeb results in increased expression of MDM2 mRNA] CTD PMID:27235710 Mdm2 Rat luteolin increases expression EXP 6480464 Luteolin results in increased expression of MDM2 mRNA CTD PMID:31201582 Mdm2 Rat luteolin multiple interactions EXP 6480464 Luteolin promotes the reaction [Hydrogen Peroxide results in increased expression of MDM2 mRNA] CTD PMID:27525270 Mdm2 Rat LY294002 increases expression ISO MDM2 (Homo sapiens) 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of MDM2 protein CTD PMID:16412023 Mdm2 Rat mancozeb multiple interactions ISO MDM2 (Homo sapiens) 6480464 lupeol inhibits the reaction [mancozeb results in increased expression of MDM2 mRNA] CTD PMID:27235710 Mdm2 Rat mancozeb increases expression ISO MDM2 (Homo sapiens) 6480464 mancozeb results in increased expression of MDM2 mRNA CTD PMID:27235710 Mdm2 Rat manganese atom multiple interactions EXP 6480464 [Manganese co-treated with NGF protein] results in decreased expression of MDM2 protein and PPM1D protein inhibits the reaction [[Manganese co-treated with NGF protein] results in decreased expression of MDM2 protein] CTD PMID:25791630 Mdm2 Rat manganese atom decreases expression EXP 6480464 Manganese results in decreased expression of MDM2 protein CTD PMID:25791630 Mdm2 Rat manganese(0) decreases expression EXP 6480464 Manganese results in decreased expression of MDM2 protein CTD PMID:25791630 Mdm2 Rat manganese(0) multiple interactions EXP 6480464 [Manganese co-treated with NGF protein] results in decreased expression of MDM2 protein and PPM1D protein inhibits the reaction [[Manganese co-treated with NGF protein] results in decreased expression of MDM2 protein] CTD PMID:25791630 Mdm2 Rat manganese(II) chloride increases expression EXP 6480464 manganese chloride results in increased expression of MDM2 mRNA CTD PMID:28801915 Mdm2 Rat menadione decreases expression ISO MDM2 (Homo sapiens) 6480464 Vitamin K 3 results in decreased expression of MDM2 protein CTD PMID:25005833 Mdm2 Rat menadione multiple interactions ISO MDM2 (Homo sapiens) 6480464 EUK-134 inhibits the reaction [Vitamin K 3 results in decreased expression of MDM2 protein] CTD PMID:25005833 Mdm2 Rat mercury dibromide increases expression ISO MDM2 (Homo sapiens) 6480464 mercuric bromide results in increased expression of MDM2 mRNA CTD PMID:26272509 Mdm2 Rat mercury dibromide multiple interactions ISO MDM2 (Homo sapiens) 6480464 [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MDM2 mRNA CTD PMID:27188386 Mdm2 Rat mercury dichloride decreases expression ISO Mdm2 (Mus musculus) 6480464 Mercuric Chloride results in decreased expression of MDM2 mRNA CTD PMID:23202902 Mdm2 Rat metformin increases expression EXP 6480464 Metformin results in increased expression of MDM2 mRNA CTD PMID:25596134 Mdm2 Rat methapyrilene decreases expression EXP 6480464 Methapyrilene results in decreased expression of MDM2 mRNA CTD PMID:22584684 Mdm2 Rat methapyrilene increases phosphorylation EXP 6480464 Methapyrilene results in increased phosphorylation of MDM2 protein CTD PMID:26558467 Mdm2 Rat methapyrilene increases expression EXP 6480464 Methapyrilene results in increased expression of MDM2 mRNA CTD PMID:15890375 more ... Mdm2 Rat methotrexate multiple interactions ISO MDM2 (Homo sapiens) 6480464 Methotrexate results in increased activity of and results in increased expression of MDM2 protein more ... CTD PMID:21624110 Mdm2 Rat methotrexate affects expression ISO Mdm2 (Mus musculus) 6480464 Methotrexate affects the expression of MDM2 mRNA CTD PMID:18502557 Mdm2 Rat methotrexate increases expression ISO MDM2 (Homo sapiens) 6480464 Methotrexate results in increased expression of MDM2 mRNA and Methotrexate results in increased expression of MDM2 protein CTD PMID:17637740 more ... Mdm2 Rat methyl caffeate affects binding ISO MDM2 (Homo sapiens) 6480464 methyl caffeate binds to MDM2 protein CTD PMID:26415618 Mdm2 Rat methyl methanesulfonate increases expression ISO MDM2 (Homo sapiens) 6480464 Methyl Methanesulfonate results in increased expression of MDM2 mRNA and Methyl Methanesulfonate results in increased expression of MDM2 protein CTD PMID:23649840 and PMID:25078064 Mdm2 Rat methylarsonic acid increases expression EXP 6480464 monomethylarsonic acid results in increased expression of MDM2 mRNA CTD PMID:17481689 Mdm2 Rat methylarsonic acid multiple interactions ISO MDM2 (Homo sapiens) 6480464 [sodium arsenite co-treated with monomethylarsonic acid co-treated with Cacodylic Acid] affects the expression of MDM2 mRNA CTD PMID:23192986 Mdm2 Rat methylmercury chloride decreases expression ISO Mdm2 (Mus musculus) 6480464 methylmercuric chloride results in decreased expression of MDM2 mRNA CTD PMID:23202902 Mdm2 Rat methylmercury chloride increases expression ISO MDM2 (Homo sapiens) 6480464 methylmercuric chloride results in increased expression of MDM2 mRNA CTD PMID:28001369 Mdm2 Rat methylmercury(1+) multiple interactions EXP 6480464 [Benzene co-treated with methylmercury II co-treated with Trichloroethylene] results in increased expression of MDM2 mRNA CTD PMID:17905399 Mdm2 Rat microcystin-LR decreases expression EXP 6480464 cyanoginosin LR results in decreased expression of MDM2 protein CTD PMID:31157505 Mdm2 Rat microcystin-LR decreases expression ISO Mdm2 (Mus musculus) 6480464 cyanoginosin LR results in decreased expression of MDM2 mRNA and cyanoginosin LR results in decreased expression of MDM2 protein CTD PMID:28414124 Mdm2 Rat mifepristone increases expression ISO Mdm2 (Mus musculus) 6480464 Mifepristone results in increased expression of MDM2 mRNA CTD PMID:12605714 Mdm2 Rat mitomycin C multiple interactions ISO MDM2 (Homo sapiens) 6480464 [Mitomycin results in increased stability of TP53 protein] which results in increased expression of MDM2 mRNA CTD PMID:20536192 Mdm2 Rat mitomycin C increases expression ISO MDM2 (Homo sapiens) 6480464 Mitomycin results in increased expression of MDM2 protein CTD PMID:18096571 Mdm2 Rat mitomycin C increases expression ISO Mdm2 (Mus musculus) 6480464 Mitomycin results in increased expression of MDM2 mRNA CTD PMID:25270620 Mdm2 Rat mitoxantrone decreases response to substance ISO MDM2 (Homo sapiens) 6480464 MDM2 promoter SNP results in decreased susceptibility to Mitoxantrone CTD PMID:17575151 Mdm2 Rat mono(2-ethylhexyl) phthalate decreases expression ISO MDM2 (Homo sapiens) 6480464 mono-(2-ethylhexyl)phthalate results in decreased expression of MDM2 protein CTD PMID:24706461 Mdm2 Rat monocrotaline multiple interactions ISO Mdm2 (Mus musculus) 6480464 [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of MDM2 mRNA CTD PMID:21224054 Mdm2 Rat monosodium L-glutamate multiple interactions ISO Mdm2 (Mus musculus) 6480464 [Fats and Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of MDM2 mRNA CTD PMID:23783067 Mdm2 Rat motexafin gadolinium multiple interactions ISO MDM2 (Homo sapiens) 6480464 motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of MDM2 mRNA] CTD PMID:16357179 Mdm2 Rat motexafin gadolinium increases expression ISO MDM2 (Homo sapiens) 6480464 motexafin gadolinium results in increased expression of MDM2 mRNA CTD PMID:16357179 Mdm2 Rat N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine increases expression ISO MDM2 (Homo sapiens) 6480464 N more ... CTD PMID:33645215 Mdm2 Rat N-acetylsphingosine decreases expression ISO MDM2 (Homo sapiens) 6480464 N-acetylsphingosine results in decreased expression of MDM2 mRNA and N-acetylsphingosine results in decreased expression of MDM2 protein CTD PMID:18206046 Mdm2 Rat N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal increases expression ISO Mdm2 (Mus musculus) 6480464 benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of MDM2 mRNA CTD PMID:20061341 Mdm2 Rat N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal multiple interactions ISO MDM2 (Homo sapiens) 6480464 benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [Etoposide promotes the reaction [MDM2 protein binds to TOP2A protein]] CTD PMID:17575151 Mdm2 Rat N-ethyl-N-nitrosourea increases expression EXP 6480464 Ethylnitrosourea results in increased expression of MDM2 mRNA CTD PMID:15954086 Mdm2 Rat N-ethyl-N-nitrosourea increases expression ISO Mdm2 (Mus musculus) 6480464 Ethylnitrosourea results in increased expression of MDM2 mRNA CTD PMID:19100860 Mdm2 Rat N-methyl-N'-nitro-N-nitrosoguanidine increases expression ISO MDM2 (Homo sapiens) 6480464 Methylnitronitrosoguanidine results in increased expression of MDM2 mRNA CTD PMID:12634122 Mdm2 Rat N-methyl-N'-nitro-N-nitrosoguanidine multiple interactions ISO Mdm2 (Mus musculus) 6480464 Cadmium Chloride promotes the reaction [Methylnitronitrosoguanidine results in increased expression of MDM2 protein] CTD PMID:12135628 Mdm2 Rat N-methyl-N'-nitro-N-nitrosoguanidine increases expression ISO Mdm2 (Mus musculus) 6480464 Methylnitronitrosoguanidine results in increased expression of MDM2 protein CTD PMID:12135628 Mdm2 Rat N-methyl-N-nitrosourea increases expression EXP 6480464 Methylnitrosourea results in increased expression of MDM2 mRNA CTD PMID:28688903 Mdm2 Rat N-nitrosodiethylamine multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] affects the expression of and affects the localization of MDM2 protein and [Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of MDM2 mRNA CTD PMID:11003613 and PMID:18544905 Mdm2 Rat N-nitrosodiethylamine increases expression EXP 6480464 Diethylnitrosamine results in increased expression of MDM2 mRNA and Diethylnitrosamine results in increased expression of MDM2 protein CTD PMID:14555611 more ... Mdm2 Rat N-nitrosodiethylamine multiple interactions ISO Mdm2 (Mus musculus) 6480464 RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of MDM2 mRNA] CTD PMID:17854601 Mdm2 Rat N-nitrosodiethylamine increases expression ISO Mdm2 (Mus musculus) 6480464 Diethylnitrosamine results in increased expression of MDM2 mRNA and Diethylnitrosamine results in increased expression of MDM2 protein CTD PMID:17854601 more ... Mdm2 Rat N-nitrosodimethylamine increases expression EXP 6480464 Dimethylnitrosamine results in increased expression of MDM2 mRNA CTD PMID:14600272 and PMID:15890375 Mdm2 Rat N-nitrosomorpholine increases expression EXP 6480464 N-nitrosomorpholine results in increased expression of MDM2 mRNA and N-nitrosomorpholine results in increased expression of MDM2 protein CTD PMID:14587038 and PMID:19716841 Mdm2 Rat N-Vinyl-2-pyrrolidone multiple interactions EXP 6480464 [N-vinyl-2-pyrrolidinone binds to N-vinyl-2-pyrrolidinone] which affects the expression of MDM2 mRNA CTD PMID:22037397 Mdm2 Rat nefazodone increases expression EXP 6480464 nefazodone results in increased expression of MDM2 mRNA CTD PMID:24136188 Mdm2 Rat nickel atom increases expression ISO MDM2 (Homo sapiens) 6480464 Nickel results in increased expression of MDM2 mRNA CTD PMID:24068677 Mdm2 Rat nickel atom multiple interactions ISO MDM2 (Homo sapiens) 6480464 TP53 protein affects the reaction [Nickel results in increased expression of MDM2 mRNA] CTD PMID:24068677 Mdm2 Rat nickel dichloride increases expression ISO MDM2 (Homo sapiens) 6480464 nickel chloride results in increased expression of MDM2 mRNA CTD PMID:23566959 and PMID:28552779 Mdm2 Rat nickel dichloride affects expression EXP 6480464 nickel chloride affects the expression of MDM2 mRNA CTD PMID:22546817 Mdm2 Rat nickel dichloride multiple interactions ISO MDM2 (Homo sapiens) 6480464 TP53 protein affects the reaction [nickel chloride results in increased expression of MDM2 mRNA] CTD PMID:23566959 Mdm2 Rat nicotinamide increases expression ISO MDM2 (Homo sapiens) 6480464 Niacinamide results in increased expression of MDM2 mRNA CTD PMID:16998810 Mdm2 Rat nicotine multiple interactions ISO MDM2 (Homo sapiens) 6480464 [[Nicotine results in decreased expression of RPS27A protein] which results in increased phosphorylation of MDM2 protein] which results in increased ubiquitination of TP53 protein and [Nicotine results in decreased expression of RPS27A protein] which results in increased phosphorylation of MDM2 protein CTD PMID:30272249 Mdm2 Rat nimesulide increases expression EXP 6480464 nimesulide results in increased expression of MDM2 mRNA CTD PMID:24136188 Mdm2 Rat nitenpyram increases expression ISO MDM2 (Homo sapiens) 6480464 nitenpyram results in increased expression of MDM2 mRNA CTD PMID:35568224 Mdm2 Rat Nodularin increases expression ISO MDM2 (Homo sapiens) 6480464 nodularin results in increased expression of MDM2 mRNA CTD PMID:30562542 Mdm2 Rat Nutlin-3 multiple interactions ISO MDM2 (Homo sapiens) 6480464 [Dactinomycin co-treated with nutlin 3] results in increased expression of MDM2 mRNA more ... CTD PMID:16439685 more ... Mdm2 Rat Nutlin-3 decreases expression ISO MDM2 (Homo sapiens) 6480464 nutlin 3 results in decreased expression of MDM2 protein CTD PMID:35213076 Mdm2 Rat Nutlin-3 multiple interactions ISO Mdm2 (Mus musculus) 6480464 nutlin 3 inhibits the reaction [Cisplatin results in increased expression of MDM2 protein] CTD PMID:32856486 Mdm2 Rat Nutlin-3 increases expression ISO Mdm2 (Mus musculus) 6480464 nutlin 3 results in increased expression of MDM2 mRNA CTD PMID:16949053 Mdm2 Rat Nutlin-3 increases expression ISO MDM2 (Homo sapiens) 6480464 nutlin 3 results in increased expression of MDM2 mRNA more ... CTD PMID:16014563 more ... Mdm2 Rat O-methyleugenol increases expression EXP 6480464 methyleugenol results in increased expression of MDM2 mRNA CTD PMID:26011634 Mdm2 Rat ochratoxin A increases expression EXP 6480464 ochratoxin A results in increased expression of MDM2 mRNA CTD PMID:23358140 Mdm2 Rat ochratoxin A decreases expression ISO MDM2 (Homo sapiens) 6480464 ochratoxin A results in decreased expression of MDM2 mRNA CTD PMID:30763683 Mdm2 Rat Octicizer increases expression ISO MDM2 (Homo sapiens) 6480464 2-ethylhexyldiphenylphosphate results in increased expression of MDM2 mRNA CTD PMID:30981936 Mdm2 Rat ortho-Aminoazotoluene increases expression ISO Mdm2 (Mus musculus) 6480464 o-Aminoazotoluene results in increased expression of MDM2 mRNA CTD PMID:15346788 Mdm2 Rat ouabain multiple interactions ISO MDM2 (Homo sapiens) 6480464 Ouabain results in decreased expression of and results in decreased phosphorylation of MDM2 protein CTD PMID:31436044 Mdm2 Rat oxaliplatin increases expression EXP 6480464 oxaliplatin results in increased expression of MDM2 mRNA CTD PMID:25729387 Mdm2 Rat oxaliplatin multiple interactions EXP 6480464 [oxaliplatin co-treated with Topotecan] results in increased expression of MDM2 mRNA CTD PMID:25729387 Mdm2 Rat oxfendazole decreases phosphorylation EXP 6480464 oxfendazole results in decreased phosphorylation of MDM2 protein CTD PMID:26558467 Mdm2 Rat oxfendazole increases expression EXP 6480464 oxfendazole results in increased expression of MDM2 mRNA CTD PMID:26558467 Mdm2 Rat p-chloromercuribenzoic acid increases expression ISO MDM2 (Homo sapiens) 6480464 p-Chloromercuribenzoic Acid results in increased expression of MDM2 mRNA CTD PMID:26272509 Mdm2 Rat p-chloromercuribenzoic acid multiple interactions ISO MDM2 (Homo sapiens) 6480464 [NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MDM2 mRNA CTD PMID:27188386 Mdm2 Rat paclitaxel decreases response to substance ISO MDM2 (Homo sapiens) 6480464 MDM2 protein results in decreased susceptibility to Paclitaxel CTD PMID:13130078 Mdm2 Rat palmatine affects binding ISO MDM2 (Homo sapiens) 6480464 palmatine binds to MDM2 protein CTD PMID:35997646 Mdm2 Rat paracetamol multiple interactions ISO Mdm2 (Mus musculus) 6480464 [Clofibrate co-treated with Acetaminophen] affects the expression of MDM2 mRNA and PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of MDM2 mRNA] CTD PMID:17585979 Mdm2 Rat paracetamol increases expression ISO MDM2 (Homo sapiens) 6480464 Acetaminophen results in increased expression of MDM2 mRNA CTD PMID:22230336 Mdm2 Rat paracetamol decreases expression ISO MDM2 (Homo sapiens) 6480464 Acetaminophen results in decreased expression of MDM2 mRNA CTD PMID:21420995 Mdm2 Rat paracetamol decreases expression EXP 6480464 Acetaminophen results in decreased expression of MDM2 mRNA CTD PMID:21807079 Mdm2 Rat paracetamol increases phosphorylation EXP 6480464 Acetaminophen results in increased phosphorylation of MDM2 protein CTD PMID:16330492 Mdm2 Rat paracetamol increases expression EXP 6480464 Acetaminophen results in increased expression of MDM2 mRNA CTD PMID:17202762 and PMID:33387578 Mdm2 Rat paracetamol multiple interactions EXP 6480464 Acetaminophen promotes the reaction [MDM2 protein binds to TP53 protein] CTD PMID:16330492 Mdm2 Rat paracetamol affects expression ISO Mdm2 (Mus musculus) 6480464 Acetaminophen affects the expression of MDM2 mRNA CTD PMID:17562736 Mdm2 Rat paracetamol increases expression ISO Mdm2 (Mus musculus) 6480464 Acetaminophen results in increased expression of MDM2 mRNA CTD PMID:26056430 Mdm2 Rat Paraoxon-methyl increases expression ISO MDM2 (Homo sapiens) 6480464 methylparaoxon results in increased expression of MDM2 mRNA CTD PMID:18418871 Mdm2 Rat paraquat multiple interactions ISO Mdm2 (Mus musculus) 6480464 GPX1 protein affects the reaction [Paraquat affects the expression of MDM2 mRNA] CTD PMID:12654481 Mdm2 Rat paraquat increases expression EXP 6480464 Paraquat results in increased expression of MDM2 mRNA CTD PMID:32680482 Mdm2 Rat paraquat increases expression ISO MDM2 (Homo sapiens) 6480464 Paraquat results in increased expression of MDM2 mRNA CTD PMID:20883675 and PMID:34097952 Mdm2 Rat parathion multiple interactions ISO MDM2 (Homo sapiens) 6480464 [Estradiol co-treated with Parathion] results in increased expression of MDM2 mRNA CTD PMID:17622325 Mdm2 Rat parathion-methyl increases expression ISO MDM2 (Homo sapiens) 6480464 Methyl Parathion results in increased expression of MDM2 mRNA CTD PMID:18418871 Mdm2 Rat PCB138 increases phosphorylation ISO MDM2 (Homo sapiens) 6480464 2 more ... CTD PMID:19751709 Mdm2 Rat PD123319 multiple interactions ISO MDM2 (Homo sapiens) 6480464 PD 123319 inhibits the reaction [AGT protein results in increased expression of MDM2 mRNA] and PD 123319 inhibits the reaction [AGT protein results in increased expression of MDM2 protein] CTD PMID:18206046 Mdm2 Rat pentachlorophenol increases expression ISO Mdm2 (Mus musculus) 6480464 Pentachlorophenol results in increased expression of MDM2 mRNA CTD PMID:23892564 Mdm2 Rat perfluorooctanoic acid increases expression EXP 6480464 perfluorooctanoic acid results in increased expression of MDM2 mRNA CTD PMID:19162173 Mdm2 Rat phenobarbital increases expression ISO Mdm2 (Mus musculus) 6480464 Phenobarbital results in increased expression of MDM2 mRNA CTD PMID:19482888 more ... Mdm2 Rat phenobarbital multiple interactions ISO Mdm2 (Mus musculus) 6480464 NR1I3 protein affects the reaction [Phenobarbital results in increased expression of MDM2 mRNA] and NR1I3 protein promotes the reaction [Phenobarbital results in increased expression of MDM2 mRNA] CTD PMID:19482888 Mdm2 Rat phenobarbital increases phosphorylation ISO MDM2 (Homo sapiens) 6480464 Phenobarbital results in increased phosphorylation of MDM2 protein CTD PMID:19751709 Mdm2 Rat phenobarbital increases expression EXP 6480464 Phenobarbital results in increased expression of MDM2 mRNA CTD PMID:25145657 Mdm2 Rat phenylmercury acetate increases expression ISO MDM2 (Homo sapiens) 6480464 Phenylmercuric Acetate results in increased expression of MDM2 mRNA CTD PMID:26272509 Mdm2 Rat phenylmercury acetate multiple interactions ISO MDM2 (Homo sapiens) 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MDM2 mRNA CTD PMID:27188386 Mdm2 Rat phenytoin multiple interactions ISO Mdm2 (Mus musculus) 6480464 [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of MDM2 mRNA CTD PMID:21224054 Mdm2 Rat PhIP increases expression ISO MDM2 (Homo sapiens) 6480464 2-amino-1-methyl-6-phenylimidazo(4 and 5-b)pyridine results in increased expression of MDM2 protein CTD PMID:15635149 Mdm2 Rat phlorizin decreases expression ISO Mdm2 (Mus musculus) 6480464 Phlorhizin results in decreased expression of MDM2 mRNA CTD PMID:22538082 Mdm2 Rat phosphoramide mustard increases expression EXP 6480464 phosphoramide mustard results in increased expression of MDM2 mRNA CTD PMID:26708502 Mdm2 Rat picoxystrobin increases expression ISO MDM2 (Homo sapiens) 6480464 picoxystrobin results in increased expression of MDM2 mRNA CTD PMID:33512557 Mdm2 Rat pifithrin-? multiple interactions EXP 6480464 pifithrin inhibits the reaction [Arsenic Trioxide results in increased expression of MDM2 mRNA] CTD PMID:17487067 Mdm2 Rat pifithrin-? multiple interactions ISO Mdm2 (Mus musculus) 6480464 pifithrin inhibits the reaction [Doxorubicin results in increased expression of MDM2 mRNA] and pifithrin inhibits the reaction [Vehicle Emissions results in decreased expression of MDM2 protein] CTD PMID:14766674 and PMID:18940243 Mdm2 Rat piperonyl butoxide increases expression EXP 6480464 Piperonyl Butoxide results in increased expression of MDM2 mRNA CTD PMID:15890375 and PMID:22484513 Mdm2 Rat pirinixic acid multiple interactions EXP 6480464 MDM2 protein affects the reaction [pirinixic acid results in increased activity of PPARA protein] more ... CTD PMID:19103650 Mdm2 Rat pirinixic acid increases expression EXP 6480464 pirinixic acid results in increased expression of MDM2 mRNA CTD PMID:15890375 and PMID:19162173 Mdm2 Rat platycodin D decreases expression ISO MDM2 (Homo sapiens) 6480464 platycodin D results in decreased expression of MDM2 protein CTD PMID:25431082 and PMID:27432230 Mdm2 Rat platycodin D multiple interactions ISO MDM2 (Homo sapiens) 6480464 MDM2 protein inhibits the reaction [platycodin D results in increased expression of FOXO3 protein] CTD PMID:25431082 Mdm2 Rat poly(vinylpyrrolidone) multiple interactions ISO MDM2 (Homo sapiens) 6480464 [Silver co-treated with Povidone] affects the expression of MDM2 protein and [Silver co-treated with Povidone] results in decreased expression of MDM2 mRNA CTD PMID:27387714 Mdm2 Rat potassium bromate increases expression ISO MDM2 (Homo sapiens) 6480464 potassium bromate results in increased expression of MDM2 mRNA CTD PMID:30559759 Mdm2 Rat potassium dichromate multiple interactions EXP 6480464 Ascorbic Acid inhibits the reaction [Potassium Dichromate results in decreased expression of MDM2 protein] CTD PMID:21262251 Mdm2 Rat potassium dichromate decreases expression EXP 6480464 Potassium Dichromate results in decreased expression of MDM2 protein CTD PMID:21262251 Mdm2 Rat pravastatin increases phosphorylation ISO MDM2 (Homo sapiens) 6480464 Pravastatin results in increased phosphorylation of MDM2 protein CTD PMID:15625077 Mdm2 Rat pravastatin increases expression EXP 6480464 Pravastatin results in increased expression of MDM2 protein CTD PMID:15625077 Mdm2 Rat pravastatin multiple interactions ISO MDM2 (Homo sapiens) 6480464 [Pravastatin results in increased phosphorylation of MDM2 protein] which results in increased degradation of TP53 protein more ... CTD PMID:15625077 Mdm2 Rat pregnenolone 16alpha-carbonitrile increases expression EXP 6480464 Pregnenolone Carbonitrile results in increased expression of MDM2 mRNA CTD PMID:19162173 Mdm2 Rat prochloraz multiple interactions EXP 6480464 [cyproconazole co-treated with epoxiconazole co-treated with prochloraz] results in increased expression of MDM2 mRNA CTD PMID:29038839 Mdm2 Rat procymidone decreases expression EXP 6480464 procymidone results in decreased expression of MDM2 mRNA CTD PMID:15686871 Mdm2 Rat promethazine increases phosphorylation EXP 6480464 Promethazine results in increased phosphorylation of MDM2 protein CTD PMID:26558467 Mdm2 Rat propanal increases expression ISO MDM2 (Homo sapiens) 6480464 propionaldehyde results in increased expression of MDM2 mRNA CTD PMID:26079696 Mdm2 Rat PX-866 decreases phosphorylation ISO MDM2 (Homo sapiens) 6480464 PX-866 results in decreased phosphorylation of MDM2 protein CTD PMID:27017931 Mdm2 Rat PX-866 multiple interactions ISO MDM2 (Homo sapiens) 6480464 [Raloxifene Hydrochloride co-treated with PX-866] results in decreased phosphorylation of MDM2 protein CTD PMID:27017931 Mdm2 Rat quercetin multiple interactions ISO MDM2 (Homo sapiens) 6480464 Quercetin results in decreased phosphorylation of and results in decreased expression of MDM2 protein CTD PMID:17973296 Mdm2 Rat quercetin increases expression ISO MDM2 (Homo sapiens) 6480464 Quercetin results in increased expression of MDM2 mRNA CTD PMID:21632981 more ... Mdm2 Rat quercetin multiple interactions EXP 6480464 [Quercetin co-treated with Hydrogen Peroxide] results in increased expression of MDM2 mRNA CTD PMID:27525270 Mdm2 Rat quercetin decreases expression ISO MDM2 (Homo sapiens) 6480464 Quercetin results in decreased expression of MDM2 protein CTD PMID:21933852 Mdm2 Rat quercetin increases expression EXP 6480464 Quercetin results in increased expression of MDM2 mRNA CTD PMID:31201582 Mdm2 Rat raloxifene multiple interactions ISO MDM2 (Homo sapiens) 6480464 [Raloxifene Hydrochloride co-treated with PX-866] results in decreased phosphorylation of MDM2 protein CTD PMID:27017931 Mdm2 Rat reactive oxygen species multiple interactions ISO MDM2 (Homo sapiens) 6480464 [[[CD40LG protein co-treated with IL4 protein] results in increased abundance of Reactive Oxygen Species] which results in increased expression of and results in increased phosphorylation of and results in increased stability of TP53 protein] which results in increased expression of MDM2 protein CTD PMID:27634759 Mdm2 Rat resveratrol multiple interactions ISO MDM2 (Homo sapiens) 6480464 [Plant Extracts co-treated with Resveratrol] results in increased expression of MDM2 mRNA more ... CTD PMID:15542774 more ... Mdm2 Rat resveratrol increases expression ISO MDM2 (Homo sapiens) 6480464 resveratrol results in increased expression of MDM2 mRNA CTD PMID:15280659 more ... Mdm2 Rat resveratrol multiple interactions ISO Mdm2 (Mus musculus) 6480464 [resveratrol results in increased phosphorylation of TRP53 protein] inhibits the reaction [TRP53 protein binds to MDM2 protein] CTD PMID:11245472 Mdm2 Rat resveratrol decreases expression ISO MDM2 (Homo sapiens) 6480464 resveratrol results in decreased expression of MDM2 mRNA and resveratrol results in decreased expression of MDM2 protein CTD PMID:16998810 more ... Mdm2 Rat resveratrol increases expression ISO Mdm2 (Mus musculus) 6480464 resveratrol results in increased expression of MDM2 mRNA and resveratrol results in increased expression of MDM2 protein CTD PMID:11245472 more ... Mdm2 Rat resveratrol affects expression ISO Mdm2 (Mus musculus) 6480464 resveratrol affects the expression of MDM2 protein CTD PMID:16369916 Mdm2 Rat rifampicin multiple interactions ISO Mdm2 (Mus musculus) 6480464 [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of MDM2 mRNA CTD PMID:21224054 Mdm2 Rat rotenone increases expression ISO MDM2 (Homo sapiens) 6480464 Rotenone results in increased expression of MDM2 mRNA CTD PMID:33512557 Mdm2 Rat ruthenium atom decreases expression ISO MDM2 (Homo sapiens) 6480464 Ruthenium results in decreased expression of MDM2 protein CTD PMID:17210701 Mdm2 Rat S-(1,2-dichlorovinyl)-L-cysteine increases expression ISO MDM2 (Homo sapiens) 6480464 S-(1 and 2-dichlorovinyl)cysteine results in increased expression of MDM2 mRNA CTD PMID:36576512 Mdm2 Rat SB 431542 multiple interactions ISO MDM2 (Homo sapiens) 6480464 [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 Mdm2 Rat selinexor multiple interactions ISO MDM2 (Homo sapiens) 6480464 [INCB057643 co-treated with selinexor] results in increased expression of MDM2 protein CTD PMID:37899423 Mdm2 Rat selinexor increases expression ISO MDM2 (Homo sapiens) 6480464 selinexor results in increased expression of MDM2 protein CTD PMID:37899423 Mdm2 Rat silicon dioxide increases expression ISO Mdm2 (Mus musculus) 6480464 Silicon Dioxide results in increased expression of MDM2 mRNA CTD PMID:19073995 Mdm2 Rat silver atom multiple interactions ISO MDM2 (Homo sapiens) 6480464 [Silver co-treated with Povidone] affects the expression of MDM2 protein and [Silver co-treated with Povidone] results in decreased expression of MDM2 mRNA CTD PMID:27387714 Mdm2 Rat silver atom decreases expression ISO MDM2 (Homo sapiens) 6480464 Silver results in decreased expression of MDM2 mRNA CTD PMID:26014281 Mdm2 Rat silver(0) multiple interactions ISO MDM2 (Homo sapiens) 6480464 [Silver co-treated with Povidone] affects the expression of MDM2 protein and [Silver co-treated with Povidone] results in decreased expression of MDM2 mRNA CTD PMID:27387714 Mdm2 Rat silver(0) decreases expression ISO MDM2 (Homo sapiens) 6480464 Silver results in decreased expression of MDM2 mRNA CTD PMID:26014281 Mdm2 Rat simvastatin increases phosphorylation ISO MDM2 (Homo sapiens) 6480464 Simvastatin results in increased phosphorylation of MDM2 protein CTD PMID:15625077 Mdm2 Rat simvastatin multiple interactions ISO MDM2 (Homo sapiens) 6480464 Simvastatin promotes the reaction [Benzo(a)pyrene promotes the reaction [TP53 protein binds to MDM2 protein]] CTD PMID:15625077 Mdm2 Rat sirolimus multiple interactions ISO MDM2 (Homo sapiens) 6480464 EIF4E protein inhibits the reaction [Sirolimus results in decreased expression of MDM2 protein] more ... CTD PMID:15625077 more ... Mdm2 Rat sirolimus decreases expression ISO MDM2 (Homo sapiens) 6480464 Sirolimus results in decreased expression of MDM2 protein CTD PMID:19560264 Mdm2 Rat sodium arsenate increases expression ISO Mdm2 (Mus musculus) 6480464 sodium arsenate results in increased expression of MDM2 mRNA CTD PMID:11353140 Mdm2 Rat sodium arsenite multiple interactions ISO MDM2 (Homo sapiens) 6480464 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [sodium arsenite results in increased expression of MDM2 protein] more ... CTD PMID:20375080 more ... Mdm2 Rat sodium arsenite affects expression ISO MDM2 (Homo sapiens) 6480464 sodium arsenite affects the expression of MDM2 mRNA CTD PMID:29319823 Mdm2 Rat sodium arsenite increases expression ISO Mdm2 (Mus musculus) 6480464 sodium arsenite results in increased expression of MDM2 mRNA CTD PMID:11353140 and PMID:20477944 Mdm2 Rat sodium arsenite decreases expression ISO Mdm2 (Mus musculus) 6480464 sodium arsenite results in decreased expression of MDM2 protein CTD PMID:16166651 Mdm2 Rat sodium arsenite increases expression ISO MDM2 (Homo sapiens) 6480464 sodium arsenite results in increased expression of MDM2 mRNA more ... CTD PMID:11813266 more ... Mdm2 Rat sodium dichromate affects expression EXP 6480464 sodium bichromate affects the expression of MDM2 mRNA CTD PMID:11960910 and PMID:22110744 Mdm2 Rat sodium dichromate increases expression EXP 6480464 sodium bichromate results in increased expression of MDM2 mRNA CTD PMID:25993096 Mdm2 Rat sorafenib increases expression ISO MDM2 (Homo sapiens) 6480464 sorafenib results in increased expression of MDM2 mRNA CTD PMID:26409325 Mdm2 Rat staurosporine multiple interactions ISO MDM2 (Homo sapiens) 6480464 Staurosporine inhibits the reaction [EGF protein inhibits the reaction [resveratrol inhibits the reaction [TP53 protein binds to MDM2 protein]]] CTD PMID:15542774 Mdm2 Rat succimer multiple interactions ISO Mdm2 (Mus musculus) 6480464 [Succimer co-treated with Magnetite Nanoparticles] results in increased expression of MDM2 mRNA CTD PMID:26378955 Mdm2 Rat sunitinib increases expression ISO MDM2 (Homo sapiens) 6480464 Sunitinib results in increased expression of MDM2 mRNA CTD PMID:31533062 Mdm2 Rat T-2 toxin increases expression EXP 6480464 T-2 Toxin results in increased expression of MDM2 mRNA CTD PMID:26141394 Mdm2 Rat T-2 toxin increases expression ISO MDM2 (Homo sapiens) 6480464 T-2 Toxin results in increased expression of MDM2 mRNA CTD PMID:31863870 Mdm2 Rat tamoxifen affects expression ISO Mdm2 (Mus musculus) 6480464 Tamoxifen affects the expression of MDM2 mRNA CTD PMID:17555576 Mdm2 Rat tamoxifen decreases expression ISO MDM2 (Homo sapiens) 6480464 Tamoxifen results in decreased expression of MDM2 mRNA CTD PMID:34821461 Mdm2 Rat tanespimycin increases degradation ISO MDM2 (Homo sapiens) 6480464 tanespimycin results in increased degradation of MDM2 protein CTD PMID:17157164 Mdm2 Rat tauroursodeoxycholic acid increases expression EXP 6480464 ursodoxicoltaurine results in increased expression of MDM2 mRNA CTD PMID:15885361 Mdm2 Rat tebufenpyrad increases expression ISO MDM2 (Homo sapiens) 6480464 4-chloro-N-((4-(1 and 1-dimethylethyl)phenyl)methyl)-3-ethyl-1-methyl-1H-pyrazole-5-carboxamide results in increased expression of MDM2 mRNA CTD PMID:33512557 Mdm2 Rat tert-butyl hydroperoxide increases expression ISO MDM2 (Homo sapiens) 6480464 tert-Butylhydroperoxide results in increased expression of MDM2 mRNA CTD PMID:27509014 Mdm2 Rat testosterone decreases expression ISO Mdm2 (Mus musculus) 6480464 Testosterone results in decreased expression of MDM2 mRNA CTD PMID:20403060 Mdm2 Rat tetrachloromethane multiple interactions EXP 6480464 schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of MDM2 mRNA] CTD PMID:31150632 Mdm2 Rat tetrachloromethane increases expression ISO Mdm2 (Mus musculus) 6480464 Carbon Tetrachloride results in increased expression of MDM2 mRNA CTD PMID:31919559 Mdm2 Rat tetrachloromethane increases expression EXP 6480464 Carbon Tetrachloride results in increased expression of MDM2 mRNA CTD PMID:31150632 Mdm2 Rat tetraphene multiple interactions ISO Mdm2 (Mus musculus) 6480464 [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of MDM2 mRNA CTD PMID:27858113 Mdm2 Rat theaflavin multiple interactions ISO Mdm2 (Mus musculus) 6480464 [theaflavin co-treated with polylactic acid-polyglycolic acid copolymer analog] inhibits the reaction [9 more ... CTD PMID:23717041 Mdm2 Rat thioacetamide increases expression EXP 6480464 Thioacetamide results in increased expression of MDM2 mRNA CTD PMID:18619722 more ... Mdm2 Rat thioacetamide increases phosphorylation EXP 6480464 Thioacetamide results in increased phosphorylation of MDM2 protein CTD PMID:26558467 Mdm2 Rat thymoquinone decreases expression ISO MDM2 (Homo sapiens) 6480464 thymoquinone results in decreased expression of MDM2 protein CTD PMID:31433961 and PMID:34627931 Mdm2 Rat titanium dioxide increases expression ISO MDM2 (Homo sapiens) 6480464 titanium dioxide results in increased expression of MDM2 mRNA CTD PMID:21067279 Mdm2 Rat titanium dioxide decreases methylation ISO Mdm2 (Mus musculus) 6480464 titanium dioxide results in decreased methylation of MDM2 gene CTD PMID:35295148 Mdm2 Rat topotecan multiple interactions EXP 6480464 [oxaliplatin co-treated with Topotecan] results in increased expression of MDM2 mRNA CTD PMID:25729387 Mdm2 Rat topotecan multiple interactions ISO MDM2 (Homo sapiens) 6480464 [N-(oxo-5 more ... CTD PMID:23376119 Mdm2 Rat topotecan increases expression EXP 6480464 Topotecan results in increased expression of MDM2 mRNA CTD PMID:25729387 Mdm2 Rat trichloroethene affects expression ISO Mdm2 (Mus musculus) 6480464 Trichloroethylene affects the expression of MDM2 mRNA CTD PMID:21135412 Mdm2 Rat trichloroethene increases expression EXP 6480464 Trichloroethylene results in increased expression of MDM2 mRNA CTD PMID:33387578 Mdm2 Rat trichloroethene multiple interactions EXP 6480464 [Benzene co-treated with methylmercury II co-treated with Trichloroethylene] results in increased expression of MDM2 mRNA CTD PMID:17905399 Mdm2 Rat trichostatin A affects expression ISO MDM2 (Homo sapiens) 6480464 trichostatin A affects the expression of MDM2 mRNA CTD PMID:28542535 Mdm2 Rat triphenyl phosphate increases expression EXP 6480464 triphenyl phosphate results in increased expression of MDM2 mRNA CTD PMID:30589522 Mdm2 Rat triphenyl phosphate affects expression ISO MDM2 (Homo sapiens) 6480464 triphenyl phosphate affects the expression of MDM2 mRNA CTD PMID:37042841 Mdm2 Rat Triptolide increases expression ISO Mdm2 (Mus musculus) 6480464 triptolide results in increased expression of MDM2 mRNA CTD PMID:32835833 Mdm2 Rat Triptolide decreases expression ISO MDM2 (Homo sapiens) 6480464 triptolide results in decreased expression of MDM2 protein CTD PMID:36990132 Mdm2 Rat triptonide affects expression ISO Mdm2 (Mus musculus) 6480464 triptonide affects the expression of MDM2 mRNA CTD PMID:33045310 Mdm2 Rat trovafloxacin multiple interactions ISO Mdm2 (Mus musculus) 6480464 [trovafloxacin co-treated with lipopolysaccharide and E coli O55-B5] results in increased expression of MDM2 mRNA CTD PMID:18930950 Mdm2 Rat trovafloxacin increases expression ISO Mdm2 (Mus musculus) 6480464 trovafloxacin results in increased expression of MDM2 mRNA CTD PMID:35537566 Mdm2 Rat urethane multiple interactions ISO Mdm2 (Mus musculus) 6480464 [Urethane co-treated with Freund's Adjuvant] results in increased expression of MDM2 mRNA CTD PMID:12400877 Mdm2 Rat ursodeoxycholic acid multiple interactions EXP 6480464 [Ursodeoxycholic Acid promotes the reaction [TP53 protein binds to MDM2 protein]] which results in increased degradation of TP53 protein more ... CTD PMID:14514686 more ... Mdm2 Rat ursodeoxycholic acid increases expression EXP 6480464 Ursodeoxycholic Acid results in increased expression of MDM2 mRNA CTD PMID:15885361 Mdm2 Rat ursodeoxycholic acid multiple interactions ISO MDM2 (Homo sapiens) 6480464 MDM2 mutant form inhibits the reaction [Ursodeoxycholic Acid results in increased ubiquitination of TP53 protein] CTD PMID:20807506 Mdm2 Rat valdecoxib increases expression EXP 6480464 valdecoxib results in increased expression of MDM2 mRNA CTD PMID:24136188 Mdm2 Rat valproic acid increases expression ISO MDM2 (Homo sapiens) 6480464 Valproic Acid results in increased expression of MDM2 mRNA CTD PMID:23179753 Mdm2 Rat valproic acid decreases expression ISO MDM2 (Homo sapiens) 6480464 Valproic Acid results in decreased expression of MDM2 mRNA CTD PMID:28001369 Mdm2 Rat valproic acid affects expression ISO MDM2 (Homo sapiens) 6480464 Valproic Acid affects the expression of MDM2 mRNA CTD PMID:25979313 Mdm2 Rat vincristine increases expression ISO MDM2 (Homo sapiens) 6480464 Vincristine results in increased expression of MDM2 mRNA CTD PMID:23649840 Mdm2 Rat vincristine decreases expression ISO MDM2 (Homo sapiens) 6480464 Vincristine results in decreased expression of MDM2 mRNA CTD PMID:16001973 Mdm2 Rat vorinostat decreases expression ISO MDM2 (Homo sapiens) 6480464 vorinostat results in decreased expression of MDM2 mRNA CTD PMID:27188386 Mdm2 Rat wortmannin multiple interactions ISO MDM2 (Homo sapiens) 6480464 wortmannin promotes the reaction [Doxorubicin results in increased phosphorylation of MDM2 protein] and wortmannin promotes the reaction [Etoposide results in increased phosphorylation of MDM2 protein] CTD PMID:17935137 Mdm2 Rat zidovudine increases expression ISO MDM2 (Homo sapiens) 6480464 Zidovudine results in increased expression of MDM2 protein CTD PMID:16797627 Mdm2 Rat zinc acetate multiple interactions ISO MDM2 (Homo sapiens) 6480464 motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of MDM2 mRNA] CTD PMID:16357179 Mdm2 Rat zinc acetate increases expression ISO MDM2 (Homo sapiens) 6480464 Zinc Acetate results in increased expression of MDM2 mRNA CTD PMID:16357179 Mdm2 Rat zinc atom multiple interactions ISO MDM2 (Homo sapiens) 6480464 Zinc binds to and results in increased folding of MDM2 protein more ... CTD PMID:16965791 Mdm2 Rat zinc atom increases ubiquitination ISO MDM2 (Homo sapiens) 6480464 Zinc results in increased ubiquitination of MDM2 protein CTD PMID:16965791 Mdm2 Rat zinc atom affects expression ISO MDM2 (Homo sapiens) 6480464 Zinc affects the expression of MDM2 protein CTD PMID:16636310 Mdm2 Rat zinc pyrithione increases expression ISO MDM2 (Homo sapiens) 6480464 pyrithione zinc results in increased expression of MDM2 mRNA CTD PMID:21424779 Mdm2 Rat zinc(0) multiple interactions ISO MDM2 (Homo sapiens) 6480464 Zinc binds to and results in increased folding of MDM2 protein more ... CTD PMID:16965791 Mdm2 Rat zinc(0) affects expression ISO MDM2 (Homo sapiens) 6480464 Zinc affects the expression of MDM2 protein CTD PMID:16636310 Mdm2 Rat zinc(0) increases ubiquitination ISO MDM2 (Homo sapiens) 6480464 Zinc results in increased ubiquitination of MDM2 protein CTD PMID:16965791