Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Cdkn2aip | Rat | (-)-epigallocatechin 3-gallate | multiple interactions | ISO | CDKN2AIP (Homo sapiens) | 6480464 | [potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of CDKN2AIP mRNA | CTD | PMID:22079256 | Cdkn2aip | Rat | (1->4)-beta-D-glucan | multiple interactions | ISO | Cdkn2aip (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of CDKN2AIP mRNA | CTD | PMID:36331819 | Cdkn2aip | Rat | 1,2-dimethylhydrazine | decreases expression | ISO | Cdkn2aip (Mus musculus) | 6480464 | 1 and 2-Dimethylhydrazine results in decreased expression of CDKN2AIP mRNA | CTD | PMID:22206623 | Cdkn2aip | Rat | 2-hydroxypropanoic acid | increases expression | ISO | CDKN2AIP (Homo sapiens) | 6480464 | Lactic Acid results in increased expression of CDKN2AIP mRNA | CTD | PMID:30851411 | Cdkn2aip | Rat | 2-palmitoylglycerol | increases expression | ISO | CDKN2AIP (Homo sapiens) | 6480464 | 2-palmitoylglycerol results in increased expression of CDKN2AIP mRNA | CTD | PMID:37199045 | Cdkn2aip | Rat | 3,4-methylenedioxymethamphetamine | decreases expression | ISO | Cdkn2aip (Mus musculus) | 6480464 | N-Methyl-3 and 4-methylenedioxyamphetamine results in decreased expression of CDKN2AIP mRNA | CTD | PMID:26251327 | Cdkn2aip | Rat | 4,4'-diaminodiphenylmethane | affects expression | ISO | Cdkn2aip (Mus musculus) | 6480464 | 4 and 4'-diaminodiphenylmethane affects the expression of CDKN2AIP mRNA | CTD | PMID:18648102 | Cdkn2aip | Rat | 5-fluorouracil | affects response to substance | ISO | CDKN2AIP (Homo sapiens) | 6480464 | CDKN2AIP protein affects the susceptibility to Fluorouracil | CTD | PMID:16217747 | Cdkn2aip | Rat | 6-propyl-2-thiouracil | decreases expression | EXP | | 6480464 | Propylthiouracil results in decreased expression of CDKN2AIP mRNA | CTD | PMID:30047161 | Cdkn2aip | Rat | acrylamide | increases expression | ISO | CDKN2AIP (Homo sapiens) | 6480464 | Acrylamide results in increased expression of CDKN2AIP mRNA | CTD | PMID:32763439 | Cdkn2aip | Rat | aflatoxin B1 | increases expression | ISO | Cdkn2aip (Mus musculus) | 6480464 | Aflatoxin B1 results in increased expression of CDKN2AIP mRNA | CTD | PMID:19770486 | Cdkn2aip | Rat | aflatoxin B1 | decreases methylation | ISO | CDKN2AIP (Homo sapiens) | 6480464 | Aflatoxin B1 results in decreased methylation of CDKN2AIP gene | CTD | PMID:27153756 | Cdkn2aip | Rat | amitrole | decreases expression | EXP | | 6480464 | Amitrole results in decreased expression of CDKN2AIP mRNA | CTD | PMID:30047161 | Cdkn2aip | Rat | aristolochic acid A | increases expression | ISO | CDKN2AIP (Homo sapiens) | 6480464 | aristolochic acid I results in increased expression of CDKN2AIP mRNA | CTD | PMID:33212167 | Cdkn2aip | Rat | Aroclor 1254 | decreases expression | ISO | Cdkn2aip (Mus musculus) | 6480464 | Chlorodiphenyl (54% Chlorine) results in decreased expression of CDKN2AIP mRNA | CTD | PMID:23650126 | Cdkn2aip | Rat | arsenite(3-) | increases expression | ISO | Cdkn2aip (Mus musculus) | 6480464 | arsenite results in increased expression of CDKN2AIP protein | CTD | PMID:37955338 | Cdkn2aip | Rat | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of CDKN2AIP mRNA | CTD | PMID:25181051 | Cdkn2aip | Rat | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of CDKN2AIP mRNA | CTD | PMID:30816183 and PMID:32145629 | Cdkn2aip | Rat | Brodifacoum | decreases expression | EXP | | 6480464 | bromfenacoum results in decreased expression of CDKN2AIP protein | CTD | PMID:28903499 | Cdkn2aip | Rat | cadmium atom | multiple interactions | ISO | CDKN2AIP (Homo sapiens) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of CDKN2AIP mRNA | CTD | PMID:35301059 | Cdkn2aip | Rat | cadmium dichloride | multiple interactions | ISO | CDKN2AIP (Homo sapiens) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of CDKN2AIP mRNA | CTD | PMID:35301059 | Cdkn2aip | Rat | caffeine | increases phosphorylation | ISO | CDKN2AIP (Homo sapiens) | 6480464 | Caffeine results in increased phosphorylation of CDKN2AIP protein | CTD | PMID:35688186 | Cdkn2aip | Rat | cisplatin | affects response to substance | ISO | CDKN2AIP (Homo sapiens) | 6480464 | CDKN2AIP protein affects the susceptibility to Cisplatin | CTD | PMID:16217747 | Cdkn2aip | Rat | cisplatin | multiple interactions | ISO | CDKN2AIP (Homo sapiens) | 6480464 | Cisplatin promotes the reaction [jinfukang results in decreased expression of CDKN2AIP mRNA] and jinfukang promotes the reaction [Cisplatin results in decreased expression of CDKN2AIP mRNA] | CTD | PMID:27392435 | Cdkn2aip | Rat | cisplatin | decreases expression | ISO | CDKN2AIP (Homo sapiens) | 6480464 | Cisplatin results in decreased expression of CDKN2AIP mRNA | CTD | PMID:27392435 | Cdkn2aip | Rat | cisplatin | increases expression | ISO | CDKN2AIP (Homo sapiens) | 6480464 | Cisplatin results in increased expression of CDKN2AIP mRNA | CTD | PMID:27594783 | Cdkn2aip | Rat | clotrimazole | decreases expression | EXP | | 6480464 | Clotrimazole results in decreased expression of CDKN2AIP mRNA | CTD | PMID:30047161 | Cdkn2aip | Rat | copper atom | multiple interactions | ISO | CDKN2AIP (Homo sapiens) | 6480464 | [Disulfiram binds to Copper] which results in decreased expression of CDKN2AIP mRNA | CTD | PMID:24690739 | Cdkn2aip | Rat | copper(0) | multiple interactions | ISO | CDKN2AIP (Homo sapiens) | 6480464 | [Disulfiram binds to Copper] which results in decreased expression of CDKN2AIP mRNA | CTD | PMID:24690739 | Cdkn2aip | Rat | copper(II) sulfate | increases expression | ISO | CDKN2AIP (Homo sapiens) | 6480464 | Copper Sulfate results in increased expression of CDKN2AIP mRNA | CTD | PMID:19549813 | Cdkn2aip | Rat | coumestrol | decreases expression | ISO | CDKN2AIP (Homo sapiens) | 6480464 | Coumestrol results in decreased expression of CDKN2AIP mRNA | CTD | PMID:19167446 | Cdkn2aip | Rat | crocidolite asbestos | increases expression | ISO | CDKN2AIP (Homo sapiens) | 6480464 | Asbestos and Crocidolite results in increased expression of CDKN2AIP mRNA | CTD | PMID:18687144 | Cdkn2aip | Rat | crocidolite asbestos | decreases expression | ISO | Cdkn2aip (Mus musculus) | 6480464 | Asbestos and Crocidolite results in decreased expression of CDKN2AIP mRNA | CTD | PMID:29279043 | Cdkn2aip | Rat | CU-O LINKAGE | increases expression | ISO | CDKN2AIP (Homo sapiens) | 6480464 | cupric oxide results in increased expression of CDKN2AIP mRNA | CTD | PMID:22077320 | Cdkn2aip | Rat | cyclosporin A | increases expression | ISO | CDKN2AIP (Homo sapiens) | 6480464 | Cyclosporine results in increased expression of CDKN2AIP mRNA | CTD | PMID:20106945 | Cdkn2aip | Rat | Dibutyl phosphate | affects expression | ISO | CDKN2AIP (Homo sapiens) | 6480464 | di-n-butylphosphoric acid affects the expression of CDKN2AIP mRNA | CTD | PMID:37042841 | Cdkn2aip | Rat | dicrotophos | decreases expression | ISO | CDKN2AIP (Homo sapiens) | 6480464 | dicrotophos results in decreased expression of CDKN2AIP mRNA | CTD | PMID:28302478 | Cdkn2aip | Rat | disulfiram | multiple interactions | ISO | CDKN2AIP (Homo sapiens) | 6480464 | [Disulfiram binds to Copper] which results in decreased expression of CDKN2AIP mRNA | CTD | PMID:24690739 | Cdkn2aip | Rat | ethyl methanesulfonate | increases expression | ISO | CDKN2AIP (Homo sapiens) | 6480464 | Ethyl Methanesulfonate results in increased expression of CDKN2AIP mRNA | CTD | PMID:23649840 | Cdkn2aip | Rat | formaldehyde | increases expression | ISO | CDKN2AIP (Homo sapiens) | 6480464 | Formaldehyde results in increased expression of CDKN2AIP mRNA | CTD | PMID:23649840 | Cdkn2aip | Rat | FR900359 | decreases phosphorylation | ISO | CDKN2AIP (Homo sapiens) | 6480464 | FR900359 results in decreased phosphorylation of CDKN2AIP protein | CTD | PMID:37730182 | Cdkn2aip | Rat | gentamycin | increases expression | EXP | | 6480464 | Gentamicins results in increased expression of CDKN2AIP mRNA | CTD | PMID:33387578 | Cdkn2aip | Rat | gold atom | decreases expression | ISO | CDKN2AIP (Homo sapiens) | 6480464 | Gold results in decreased expression of CDKN2AIP mRNA | CTD | PMID:25523186 | Cdkn2aip | Rat | gold(0) | decreases expression | ISO | CDKN2AIP (Homo sapiens) | 6480464 | Gold results in decreased expression of CDKN2AIP mRNA | CTD | PMID:25523186 | Cdkn2aip | Rat | ivermectin | decreases expression | ISO | CDKN2AIP (Homo sapiens) | 6480464 | Ivermectin results in decreased expression of CDKN2AIP protein | CTD | PMID:32959892 | Cdkn2aip | Rat | leflunomide | increases expression | ISO | CDKN2AIP (Homo sapiens) | 6480464 | leflunomide results in increased expression of CDKN2AIP mRNA | CTD | PMID:28988120 | Cdkn2aip | Rat | methyl methanesulfonate | increases expression | ISO | CDKN2AIP (Homo sapiens) | 6480464 | Methyl Methanesulfonate results in increased expression of CDKN2AIP mRNA | CTD | PMID:23649840 | Cdkn2aip | Rat | ozone | multiple interactions | ISO | CDKN2AIP (Homo sapiens) | 6480464 | [Air Pollutants results in increased abundance of Ozone] which affects the expression of CDKN2AIP mRNA | CTD | PMID:35430440 | Cdkn2aip | Rat | paracetamol | increases expression | ISO | CDKN2AIP (Homo sapiens) | 6480464 | Acetaminophen results in increased expression of CDKN2AIP mRNA | CTD | PMID:21420995 | Cdkn2aip | Rat | paracetamol | increases expression | EXP | | 6480464 | Acetaminophen results in increased expression of CDKN2AIP mRNA | CTD | PMID:33387578 | Cdkn2aip | Rat | perfluorooctane-1-sulfonic acid | multiple interactions | ISO | Cdkn2aip (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of CDKN2AIP mRNA | CTD | PMID:36331819 | Cdkn2aip | Rat | potassium chromate | increases expression | ISO | CDKN2AIP (Homo sapiens) | 6480464 | potassium chromate(VI) results in increased expression of CDKN2AIP mRNA | CTD | PMID:22079256 | Cdkn2aip | Rat | potassium chromate | multiple interactions | ISO | CDKN2AIP (Homo sapiens) | 6480464 | [potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of CDKN2AIP mRNA | CTD | PMID:22079256 | Cdkn2aip | Rat | progesterone | increases expression | ISO | CDKN2AIP (Homo sapiens) | 6480464 | Progesterone results in increased expression of CDKN2AIP mRNA | CTD | PMID:18070364 | Cdkn2aip | Rat | rac-lactic acid | increases expression | ISO | CDKN2AIP (Homo sapiens) | 6480464 | Lactic Acid results in increased expression of CDKN2AIP mRNA | CTD | PMID:30851411 | Cdkn2aip | Rat | rotenone | increases expression | EXP | | 6480464 | Rotenone results in increased expression of CDKN2AIP protein | CTD | PMID:35544339 | Cdkn2aip | Rat | silver atom | decreases expression | ISO | Cdkn2aip (Mus musculus) | 6480464 | Silver results in decreased expression of CDKN2AIP mRNA | CTD | PMID:27131904 | Cdkn2aip | Rat | silver(0) | decreases expression | ISO | Cdkn2aip (Mus musculus) | 6480464 | Silver results in decreased expression of CDKN2AIP mRNA | CTD | PMID:27131904 | Cdkn2aip | Rat | sodium arsenite | increases expression | ISO | CDKN2AIP (Homo sapiens) | 6480464 | sodium arsenite results in increased expression of CDKN2AIP mRNA | CTD | PMID:38568856 | Cdkn2aip | Rat | sulforaphane | decreases expression | ISO | CDKN2AIP (Homo sapiens) | 6480464 | sulforaphane results in decreased expression of CDKN2AIP mRNA | CTD | PMID:31838189 | Cdkn2aip | Rat | sunitinib | increases expression | ISO | CDKN2AIP (Homo sapiens) | 6480464 | Sunitinib results in increased expression of CDKN2AIP mRNA | CTD | PMID:31533062 | Cdkn2aip | Rat | tetrachloromethane | increases expression | ISO | Cdkn2aip (Mus musculus) | 6480464 | Carbon Tetrachloride results in increased expression of CDKN2AIP mRNA | CTD | PMID:31919559 | Cdkn2aip | Rat | thioacetamide | increases expression | EXP | | 6480464 | Thioacetamide results in increased expression of CDKN2AIP mRNA | CTD | PMID:34492290 | Cdkn2aip | Rat | thiram | increases expression | ISO | CDKN2AIP (Homo sapiens) | 6480464 | Thiram results in increased expression of CDKN2AIP mRNA | CTD | PMID:38568856 | Cdkn2aip | Rat | titanium dioxide | decreases expression | ISO | Cdkn2aip (Mus musculus) | 6480464 | titanium dioxide results in decreased expression of CDKN2AIP mRNA | CTD | PMID:29264374 | Cdkn2aip | Rat | titanium dioxide | decreases methylation | ISO | Cdkn2aip (Mus musculus) | 6480464 | titanium dioxide results in decreased methylation of CDKN2AIP gene | CTD | PMID:35295148 | Cdkn2aip | Rat | triphenyl phosphate | affects expression | ISO | CDKN2AIP (Homo sapiens) | 6480464 | triphenyl phosphate affects the expression of CDKN2AIP mRNA | CTD | PMID:37042841 | Cdkn2aip | Rat | triptonide | increases expression | ISO | Cdkn2aip (Mus musculus) | 6480464 | triptonide results in increased expression of CDKN2AIP mRNA | CTD | PMID:33045310 | Cdkn2aip | Rat | valdecoxib | increases expression | EXP | | 6480464 | valdecoxib results in increased expression of CDKN2AIP mRNA | CTD | PMID:24136188 | Cdkn2aip | Rat | valproic acid | affects expression | ISO | CDKN2AIP (Homo sapiens) | 6480464 | Valproic Acid affects the expression of CDKN2AIP mRNA | CTD | PMID:25979313 | Cdkn2aip | Rat | valproic acid | decreases expression | ISO | CDKN2AIP (Homo sapiens) | 6480464 | Valproic Acid results in decreased expression of CDKN2AIP mRNA | CTD | PMID:23179753 and PMID:27188386 | Cdkn2aip | Rat | withaferin A | decreases expression | ISO | CDKN2AIP (Homo sapiens) | 6480464 | withaferin A results in decreased expression of CDKN2AIP protein | CTD | PMID:22973447 | Cdkn2aip | Rat | zoledronic acid | decreases expression | ISO | CDKN2AIP (Homo sapiens) | 6480464 | zoledronic acid results in decreased expression of CDKN2AIP mRNA | CTD | PMID:24714768 | |