Postn (periostin) - Rat Genome Database

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Gene: Postn (periostin) Rattus norvegicus
Analyze
Symbol: Postn
Name: periostin
RGD ID: 1305285
Description: Predicted to enable cell adhesion molecule binding activity; heparin binding activity; and metal ion binding activity. Involved in several processes, including bone regeneration; negative regulation of cell-substrate adhesion; and positive regulation of chemokine (C-X-C motif) ligand 2 production. Located in extracellular space and neuromuscular junction. Used to study congestive heart failure. Biomarker of artery disease (multiple); degenerative disc disease; end stage renal disease; periodontitis; and tendinitis. Orthologous to human POSTN (periostin); INTERACTS WITH (-)-anisomycin; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC361945; periostin, osteoblast specific factor; periostin-like factor; Plf
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82140,677,774 - 140,709,304 (+)NCBIGRCr8
mRatBN7.22138,527,714 - 138,559,098 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2138,527,696 - 138,559,099 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2145,095,839 - 145,127,099 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02143,207,896 - 143,239,160 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02137,839,726 - 137,870,988 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02143,656,820 - 143,688,087 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2143,656,793 - 143,688,087 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02163,331,229 - 163,362,444 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42143,537,099 - 143,568,341 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12143,487,061 - 143,518,300 (+)NCBI
Celera2133,010,117 - 133,041,246 (+)NCBICelera
Cytogenetic Map2q26NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-anisomycin  (EXP)
(1->4)-beta-D-glucan  (ISO)
1,1-dichloroethene  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3-methylcholanthrene  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
angiotensin II  (ISO)
aristolochic acids  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcium dichloride  (ISO)
chloroethene  (ISO)
choline  (ISO)
cisplatin  (ISO)
cobalt dichloride  (EXP)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
corosolic acid  (ISO)
curcumin  (ISO)
Curcumol  (ISO)
cyclophosphamide  (ISO)
cytarabine  (ISO)
decabromodiphenyl ether  (EXP)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP)
dioxygen  (ISO)
diquat  (ISO)
disulfiram  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
elemental selenium  (ISO)
entinostat  (ISO)
ethanol  (ISO)
etoposide  (ISO)
fenvalerate  (EXP)
fluorescein 5-isothiocyanate  (ISO)
folic acid  (ISO)
fulvestrant  (ISO)
furan  (EXP)
gamma-aminobutyric acid  (EXP)
gamma-Oryzanol (TN)  (EXP)
genistein  (EXP)
glyphosate  (ISO)
Ile(5)-angiotensin II  (ISO)
isoprenaline  (EXP,ISO)
ivermectin  (ISO)
L-methionine  (ISO)
lead diacetate  (ISO)
lead(0)  (ISO)
lidocaine  (EXP)
lipopolysaccharide  (ISO)
losartan  (EXP,ISO)
LY294002  (EXP)
mercury dibromide  (ISO)
methotrexate  (ISO)
milrinone  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
monocrotaline  (EXP)
N-acetyl-L-cysteine  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (EXP)
nickel atom  (ISO)
nickel sulfate  (ISO)
ochratoxin A  (EXP)
oxaliplatin  (EXP)
ozone  (ISO)
paclitaxel  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
paricalcitol  (ISO)
PD-166866  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
phosphorus atom  (ISO)
phosphorus(.)  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
raloxifene  (ISO)
razoxane  (EXP)
rofecoxib  (ISO)
rotenone  (EXP)
SB 203580  (EXP)
SB 431542  (ISO)
selenium atom  (ISO)
silicon dioxide  (EXP)
silver atom  (ISO)
silver(0)  (ISO)
sirolimus  (EXP)
sodium arsenite  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
testosterone  (EXP)
tetrachloromethane  (ISO)
thiram  (ISO)
topotecan  (EXP,ISO)
trichostatin A  (ISO)
triclosan  (ISO)
valproic acid  (ISO)
valsartan  (EXP)
vinclozolin  (EXP)
vincristine  (ISO)
wortmannin  (EXP)

References

References - curated
# Reference Title Reference Citation
1. Temporal healing in rat achilles tendon: ultrasound correlations. Chamberlain CS, etal., Ann Biomed Eng. 2013 Mar;41(3):477-87. doi: 10.1007/s10439-012-0689-y. Epub 2012 Nov 13.
2. Exposure-dependent increases in IL-1beta, substance P, CTGF, and tendinosis in flexor digitorum tendons with upper extremity repetitive strain injury. Fedorczyk JM, etal., J Orthop Res. 2009 Sep 9.
3. Thymic stromal lymphopoietin, IL-33, and periostin in hospitalized infants with viral bronchiolitis. García-García ML, etal., Medicine (Baltimore). 2017 May;96(18):e6787. doi: 10.1097/MD.0000000000006787.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Identification of periostin as a critical marker of progression/reversal of hypertensive nephropathy. Guerrot D, etal., PLoS One. 2012;7(3):e31974. doi: 10.1371/journal.pone.0031974. Epub 2012 Mar 5.
7. Expression and regulation of periostin/OSF-2 gene in rat uterus and human endometrium. Hiroi H, etal., Endocr J. 2008 Mar;55(1):183-9. Epub 2008 Feb 13.
8. [The expressions of periostin and the related factors during healing process of full-thickness cutaneous wound in rat]. Hou JJ, etal., Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2012 Jun;24(6):334-7.
9. Periostin as a novel factor responsible for ventricular dilation. Katsuragi N, etal., Circulation. 2004 Sep 28;110(13):1806-13. Epub 2004 Sep 20.
10. Corneal dystrophy-associated R124H mutation disrupts TGFBI interaction with Periostin and causes mislocalization to the lysosome. Kim BY, etal., J Biol Chem. 2009 Jul 17;284(29):19580-91. doi: 10.1074/jbc.M109.013607. Epub 2009 May 28.
11. Histochemical examinations on cortical bone regeneration induced by thermoplastic bioresorbable plates applied to bone defects of rat calvariae. Kojima T, etal., Biomed Res. 2007 Aug;28(4):219-29.
12. Phosphatidylinositol-3-kinase signaling mediates vascular smooth muscle cell expression of periostin in vivo and in vitro. Li G, etal., Atherosclerosis. 2006 Oct;188(2):292-300. Epub 2005 Dec 1.
13. [Roles of periostin in proliferation and migration of vascular smooth muscle cells and the effect of atorvastatin on them]. Li J, etal., Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2012 Jul;37(7):689-94. doi: 10.3969/j.issn.1672-7347.2012.07.007.
14. Hypoxia-responsive growth factors upregulate periostin and osteopontin expression via distinct signaling pathways in rat pulmonary arterial smooth muscle cells. Li P, etal., J Appl Physiol (1985). 2004 Oct;97(4):1550-8; discussion 1549. Epub 2004 Apr 30.
15. Vascular injury induces expression of periostin: implications for vascular cell differentiation and migration. Lindner V, etal., Arterioscler Thromb Vasc Biol. 2005 Jan;25(1):77-83. Epub 2004 Oct 28.
16. Periostin and periostin-like factor in the human heart: possible therapeutic targets. Litvin J, etal., Cardiovasc Pathol. 2006 Jan-Feb;15(1):24-32.
17. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
18. Periostin as a modulator of chronic cardiac remodeling after myocardial infarction. Minicucci MF, etal., Clinics (Sao Paulo). 2013 Oct;68(10):1344-9. doi: 10.6061/clinics/2013(10)09.
19. Left ventricular periostin gene expression is associated with fibrogenesis in experimental renal insufficiency. Pohjolainen V, etal., Nephrol Dial Transplant. 2012 Jan;27(1):115-22. doi: 10.1093/ndt/gfr279. Epub 2011 Jun 28.
20. Role of TNF alpha and PLF in bone remodeling in a rat model of repetitive reaching and grasping. Rani S, etal., J Cell Physiol. 2010 Oct;225(1):152-67. doi: 10.1002/jcp.22208.
21. Induction of periostin-like factor and periostin in forearm muscle, tendon, and nerve in an animal model of work-related musculoskeletal disorder. Rani S, etal., J Histochem Cytochem. 2009 Nov;57(11):1061-73. doi: 10.1369/jhc.2009.954081. Epub 2009 Jul 20.
22. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
23. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
24. Comprehensive gene review and curation RGD comprehensive gene curation
25. Periostin: novel tissue and urinary biomarker of progressive renal injury induces a coordinated mesenchymal phenotype in tubular cells. Satirapoj B, etal., Nephrol Dial Transplant. 2012 Jul;27(7):2702-11. doi: 10.1093/ndt/gfr670. Epub 2011 Dec 13.
26. Astroglial-derived periostin promotes axonal regeneration after spinal cord injury. Shih CH, etal., J Neurosci. 2014 Feb 12;34(7):2438-43. doi: 10.1523/JNEUROSCI.2947-13.2014.
27. Increased periostin gene expression in degenerative intervertebral disc cells. Tsai TT, etal., Spine J. 2013 Mar;13(3):289-98. doi: 10.1016/j.spinee.2013.01.040. Epub 2013 Feb 27.
28. Periostin links mechanical strain to inflammation in abdominal aortic aneurysm. Yamashita O, etal., PLoS One. 2013 Nov 19;8(11):e79753. doi: 10.1371/journal.pone.0079753. eCollection 2013.
29. Periostin-like-factor in osteogenesis. Zhu S, etal., J Cell Physiol. 2009 Mar;218(3):584-92. doi: 10.1002/jcp.21633.
Additional References at PubMed
PMID:7663166   PMID:10404027   PMID:12235007   PMID:16314533   PMID:18450759   PMID:19723774   PMID:20083223   PMID:20551380   PMID:21367774   PMID:21762408   PMID:24006456   PMID:24563484  
PMID:25173938   PMID:25303869   PMID:25894199   PMID:26281830   PMID:26541456   PMID:26644236   PMID:27068509   PMID:27220372   PMID:27559042   PMID:28849131   PMID:29941453   PMID:30890453  
PMID:31127625   PMID:31522346   PMID:32420385   PMID:32461137   PMID:33637721   PMID:33744420   PMID:33834866   PMID:35001858   PMID:35619555  


Genomics

Comparative Map Data
Postn
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82140,677,774 - 140,709,304 (+)NCBIGRCr8
mRatBN7.22138,527,714 - 138,559,098 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2138,527,696 - 138,559,099 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2145,095,839 - 145,127,099 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02143,207,896 - 143,239,160 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02137,839,726 - 137,870,988 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02143,656,820 - 143,688,087 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2143,656,793 - 143,688,087 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02163,331,229 - 163,362,444 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42143,537,099 - 143,568,341 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12143,487,061 - 143,518,300 (+)NCBI
Celera2133,010,117 - 133,041,246 (+)NCBICelera
Cytogenetic Map2q26NCBI
POSTN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381337,562,585 - 37,598,768 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1337,562,583 - 37,598,844 (-)EnsemblGRCh38hg38GRCh38
GRCh371338,136,722 - 38,172,905 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361337,034,779 - 37,070,874 (-)NCBINCBI36Build 36hg18NCBI36
Build 341337,034,778 - 37,070,874NCBI
Celera1319,190,321 - 19,226,587 (-)NCBICelera
Cytogenetic Map13q13.3NCBI
HuRef1318,936,182 - 18,972,459 (-)NCBIHuRef
CHM1_11338,104,259 - 38,140,559 (-)NCBICHM1_1
T2T-CHM13v2.01336,781,967 - 36,818,162 (-)NCBIT2T-CHM13v2.0
Postn
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39354,266,688 - 54,298,462 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl354,268,530 - 54,298,458 (+)EnsemblGRCm39 Ensembl
GRCm38354,359,267 - 54,391,041 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl354,361,109 - 54,391,037 (+)EnsemblGRCm38mm10GRCm38
MGSCv37354,165,047 - 54,194,954 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36354,449,054 - 54,478,961 (+)NCBIMGSCv36mm8
Celera354,083,066 - 54,112,946 (+)NCBICelera
Cytogenetic Map3CNCBI
cM Map325.46NCBI
Postn
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554318,510,624 - 8,544,971 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554318,510,646 - 8,544,901 (+)NCBIChiLan1.0ChiLan1.0
POSTN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21437,092,201 - 37,129,936 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11328,198,563 - 28,234,479 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01318,779,297 - 18,815,207 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11337,371,296 - 37,407,202 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1337,368,030 - 37,407,212 (-)Ensemblpanpan1.1panPan2
POSTN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1253,167,319 - 3,208,970 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl253,167,359 - 3,208,411 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha253,262,519 - 3,304,168 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0253,265,809 - 3,307,415 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl253,265,828 - 3,307,415 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1253,169,826 - 3,211,442 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0253,159,797 - 3,201,445 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0253,231,130 - 3,272,726 (+)NCBIUU_Cfam_GSD_1.0
Postn
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945164,274,642 - 164,307,376 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647231,644,778 - 31,677,572 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647231,644,778 - 31,677,572 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
POSTN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1113,224,959 - 13,258,978 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11113,225,183 - 13,258,973 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21113,200,044 - 13,233,804 (-)NCBISscrofa10.2Sscrofa10.2susScr3
POSTN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1316,060,013 - 16,095,867 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl316,059,965 - 16,095,791 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605728,185,692 - 28,221,490 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Postn
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624920540,750 - 575,855 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624920542,479 - 575,760 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Postn
46 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:232
Count of miRNA genes:153
Interacting mature miRNAs:175
Transcripts:ENSRNOT00000017453
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)225413423143657569Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
2293835Kiddil5Kidney dilation QTL 53.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607157142209Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607182042367Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)243154682202446871Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)243154682202446871Rat
2293671Bss44Bone structure and strength QTL 4410.970.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)243162366148478373Rat
1354601Slep1Serum leptin concentration QTL 15.39blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)243171017184114403Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)246123260202447032Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)256043031202447032Rat
61438Cia7Collagen induced arthritis QTL 74.60.0001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)259324377141596857Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118275202447032Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
1558653Prcr1Prostate cancer resistance QTL 15prostate integrity trait (VT:0010571)area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)272532993157142209Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)274786664206665859Rat
631198Cm22Cardiac mass QTL 224.30.0008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)276539322150540526Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)276539322202447032Rat
2299162Iddm32Insulin dependent diabetes mellitus QTL 322.36blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)278665616143657569Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)278665619219826953Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)281689826221035911Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)281754530222436696Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
631566Bp90Blood pressure QTL 900.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2102803808147803808Rat
8662836Vetf8Vascular elastic tissue fragility QTL 80.66thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2104559726149559726Rat
1581552Pur12Proteinuria QTL 125.190.0009urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)2112103657148076632Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2112456140212696837Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2112456140212696837Rat
1354594Despr10Despair related QTL 100.00000249locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)2114654253159654253Rat
1359035Bp276Blood pressure QTL 276arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2114837527143657569Rat
1359035Bp276Blood pressure QTL 276arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2114837527143657569Rat
1359030Bp277Blood pressure QTL 277arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2114837527185876470Rat
1359030Bp277Blood pressure QTL 277arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2114837527185876470Rat
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2114837527211674221Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2114837675212549332Rat
5135226Leukc2Leukocyte quantity QTL 2eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)2118111229149559726Rat
1582257Gluco21Glucose level QTL 213.10.0035blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2118111229157142209Rat
738007Anxrr7Anxiety related response QTL 74.4exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)2118189491163189491Rat
1581578Cm49Cardiac mass QTL 494.90.01heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2127447387143657569Rat
1358360Sradr2Stress Responsive Adrenal Weight QTL 210.24adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)2129164097152195315Rat
6907363Bp357Blood pressure QTL 3574.10.002arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2129540907174540907Rat
1300165Rf9Renal function QTL 93.28kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)2133914684202447032Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)2135552573202446871Rat
1298076Bp166Blood pressure QTL 1660.0009arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2136445150202447032Rat
1581502Esta3Estrogen-induced thymic atrophy QTL 3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2136916935189599348Rat
1359022Ppulsi1Prepulse inhibition QTL 13.63prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)2136916935213594495Rat
12879830Bw178Body weight QTL 1780.001body mass (VT:0001259)body weight (CMO:0000012)2137219876142323610Rat
12879831Cm82Cardiac mass QTL 820.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)2137219876142323610Rat
12879832Cm83Cardiac mass QTL 830.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2137219876142323610Rat
12879833Cm84Cardiac mass QTL 840.001heart right ventricle mass (VT:0007033)heart weight to body weight ratio (CMO:0000074)2137219876142323610Rat
12879834Am1Aortic mass QTL 10.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)2137219876142323610Rat
12879835Kidm60Kidney mass QTL 600.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2137219876142323610Rat
1549841Bp256Blood pressure QTL 2560.03arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2137219876142323610Rat

Markers in Region
D2Got432  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22138,555,474 - 138,555,761 (+)MAPPERmRatBN7.2
Rnor_6.02143,684,464 - 143,684,750NCBIRnor6.0
Rnor_5.02163,358,821 - 163,359,107UniSTSRnor5.0
Cytogenetic Map2q26UniSTS
RH132037  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22138,550,436 - 138,550,629 (+)MAPPERmRatBN7.2
Rnor_6.02143,679,426 - 143,679,618NCBIRnor6.0
Rnor_5.02163,353,843 - 163,354,035UniSTSRnor5.0
RGSC_v3.42143,559,680 - 143,559,872UniSTSRGSC3.4
Celera2133,032,697 - 133,032,889UniSTS
RH 3.4 Map2860.5UniSTS
Cytogenetic Map2q26UniSTS
AI747096  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22138,558,701 - 138,558,848 (+)MAPPERmRatBN7.2
Rnor_6.02143,687,691 - 143,687,837NCBIRnor6.0
Rnor_5.02163,362,048 - 163,362,194UniSTSRnor5.0
RGSC_v3.42143,567,945 - 143,568,091UniSTSRGSC3.4
Celera2133,040,850 - 133,040,996UniSTS
Cytogenetic Map2q26UniSTS
RH143459  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22138,546,955 - 138,547,131 (+)MAPPERmRatBN7.2
Rnor_6.02143,675,945 - 143,676,120NCBIRnor6.0
Rnor_5.02163,350,362 - 163,350,537UniSTSRnor5.0
RGSC_v3.42143,556,199 - 143,556,374UniSTSRGSC3.4
Celera2133,029,216 - 133,029,391UniSTS
RH 3.4 Map2860.5UniSTS
Cytogenetic Map2q26UniSTS
AA997633  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22138,558,825 - 138,558,936 (+)MAPPERmRatBN7.2
Rnor_6.02143,687,815 - 143,687,925NCBIRnor6.0
Rnor_5.02163,362,172 - 163,362,282UniSTSRnor5.0
RGSC_v3.42143,568,069 - 143,568,179UniSTSRGSC3.4
Celera2133,040,974 - 133,041,084UniSTS
RH 3.4 Map2860.7UniSTS
Cytogenetic Map2q26UniSTS
UniSTS:234679  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22138,533,942 - 138,534,072 (+)MAPPERmRatBN7.2
Rnor_6.02143,662,932 - 143,663,061NCBIRnor6.0
Rnor_5.02163,337,349 - 163,337,478UniSTSRnor5.0
RGSC_v3.42143,543,186 - 143,543,315UniSTSRGSC3.4
Celera2133,016,203 - 133,016,332UniSTS
Cytogenetic Map2q26UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 7
Medium 3 38 31 15 18 15 7 10 39 22 26 11 7
Low 5 19 19 1 19 1 1 35 12 5 1
Below cutoff 6 6 6 1 3

Sequence


RefSeq Acc Id: ENSRNOT00000017453   ⟹   ENSRNOP00000017453
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2138,527,842 - 138,559,099 (+)Ensembl
Rnor_6.0 Ensembl2143,656,845 - 143,688,087 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000084527   ⟹   ENSRNOP00000073724
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2138,527,701 - 138,559,096 (+)Ensembl
Rnor_6.0 Ensembl2143,656,793 - 143,688,085 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000110012   ⟹   ENSRNOP00000077367
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2138,527,696 - 138,553,668 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000110085   ⟹   ENSRNOP00000087898
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2138,527,757 - 138,559,088 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000110263   ⟹   ENSRNOP00000093637
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2138,527,842 - 138,559,096 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000113750   ⟹   ENSRNOP00000076441
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2138,527,834 - 138,559,093 (+)Ensembl
RefSeq Acc Id: NM_001108550   ⟹   NP_001102020
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82140,678,061 - 140,709,303 (+)NCBI
mRatBN7.22138,527,856 - 138,559,098 (+)NCBI
Rnor_6.02143,656,845 - 143,688,087 (+)NCBI
Rnor_5.02163,331,229 - 163,362,444 (+)NCBI
RGSC_v3.42143,537,099 - 143,568,341 (+)RGD
Celera2133,010,117 - 133,041,246 (+)RGD
Sequence:
RefSeq Acc Id: XM_006232335   ⟹   XP_006232397
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82140,677,774 - 140,709,304 (+)NCBI
mRatBN7.22138,527,853 - 138,559,096 (+)NCBI
Rnor_6.02143,656,820 - 143,688,085 (+)NCBI
Rnor_5.02163,331,229 - 163,362,444 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006232336   ⟹   XP_006232398
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82140,678,025 - 140,709,304 (+)NCBI
mRatBN7.22138,527,714 - 138,559,096 (+)NCBI
Rnor_6.02143,656,822 - 143,688,085 (+)NCBI
Rnor_5.02163,331,229 - 163,362,444 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006232337   ⟹   XP_006232399
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82140,677,903 - 140,709,304 (+)NCBI
mRatBN7.22138,527,853 - 138,559,096 (+)NCBI
Rnor_6.02143,656,822 - 143,688,085 (+)NCBI
Rnor_5.02163,331,229 - 163,362,444 (+)NCBI
Sequence:
RefSeq Acc Id: NP_001102020   ⟸   NM_001108550
- Peptide Label: precursor
- UniProtKB: D3ZAF5 (UniProtKB/TrEMBL),   A6JVB5 (UniProtKB/TrEMBL),   A0A8I6AK89 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006232397   ⟸   XM_006232335
- Peptide Label: isoform X1
- UniProtKB: A0A8I6AHK0 (UniProtKB/TrEMBL),   A0A8I6AK89 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006232398   ⟸   XM_006232336
- Peptide Label: isoform X2
- UniProtKB: A0A0G2K692 (UniProtKB/TrEMBL),   A6JVB6 (UniProtKB/TrEMBL),   A0A8I5Y6L2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006232399   ⟸   XM_006232337
- Peptide Label: isoform X3
- UniProtKB: A0A097BW25 (UniProtKB/TrEMBL),   A6JVB8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000073724   ⟸   ENSRNOT00000084527
RefSeq Acc Id: ENSRNOP00000017453   ⟸   ENSRNOT00000017453
RefSeq Acc Id: ENSRNOP00000093637   ⟸   ENSRNOT00000110263
RefSeq Acc Id: ENSRNOP00000077367   ⟸   ENSRNOT00000110012
RefSeq Acc Id: ENSRNOP00000076441   ⟸   ENSRNOT00000113750
RefSeq Acc Id: ENSRNOP00000087898   ⟸   ENSRNOT00000110085
Protein Domains
EMI   FAS1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZAF5-F1-model_v2 AlphaFold D3ZAF5 1-810 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691333
Promoter ID:EPDNEW_R1851
Type:single initiation site
Name:Postn_1
Description:periostin
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02143,656,830 - 143,656,890EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1305285 AgrOrtholog
BioCyc Gene G2FUF-53082 BioCyc
Ensembl Genes ENSRNOG00000012660 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000017453 ENTREZGENE
  ENSRNOT00000017453.4 UniProtKB/TrEMBL
  ENSRNOT00000084527.2 UniProtKB/TrEMBL
  ENSRNOT00000110012.1 UniProtKB/TrEMBL
  ENSRNOT00000110085.1 UniProtKB/TrEMBL
  ENSRNOT00000110263.1 UniProtKB/TrEMBL
  ENSRNOT00000113750.1 UniProtKB/TrEMBL
Gene3D-CATH 2.30.180.10 UniProtKB/TrEMBL
InterPro EMI_domain UniProtKB/TrEMBL
  FAS1_dom_sf UniProtKB/TrEMBL
  FAS1_domain UniProtKB/TrEMBL
  TGFb-ind_bIGH3/osteoblast_fac2 UniProtKB/TrEMBL
KEGG Report rno:361945 UniProtKB/TrEMBL
NCBI Gene 361945 ENTREZGENE
PANTHER FI05614P UniProtKB/TrEMBL
  PERIOSTIN-RELATED UniProtKB/TrEMBL
Pfam Fasciclin UniProtKB/TrEMBL
PhenoGen Postn PhenoGen
PIRSF BIGH3_OSF2 UniProtKB/TrEMBL
PROSITE EMI UniProtKB/TrEMBL
  FAS1 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000012660 RatGTEx
SMART FAS1 UniProtKB/TrEMBL
Superfamily-SCOP BIgH3_FAS1 UniProtKB/TrEMBL
UniProt A0A097BW25 ENTREZGENE, UniProtKB/TrEMBL
  A0A0G2K692 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5Y5Q6_RAT UniProtKB/TrEMBL
  A0A8I5Y6L2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AHK0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AK89 ENTREZGENE, UniProtKB/TrEMBL
  A6JVB5 ENTREZGENE, UniProtKB/TrEMBL
  A6JVB6 ENTREZGENE, UniProtKB/TrEMBL
  A6JVB8 ENTREZGENE, UniProtKB/TrEMBL
  D3ZAF5 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-05-11 Postn  periostin  Postn  periostin, osteoblast specific factor  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Postn  periostin, osteoblast specific factor   Postn_predicted  periostin, osteoblast specific factor (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Postn_predicted  periostin, osteoblast specific factor (predicted)      Symbol and Name status set to approved 70820 APPROVED