Afg3l2 (AFG3 like matrix AAA peptidase subunit 2)

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Gene: Afg3l2 (AFG3 like matrix AAA peptidase subunit 2) Rattus norvegicus

Analyze

Symbol:

Afg3l2

Name:

AFG3 like matrix AAA peptidase subunit 2

RGD ID:

1305259

Description:

Predicted to enable metalloendopeptidase activity. Predicted to be involved in calcium import into the mitochondrion; mitochondrial calcium ion homeostasis; and proteolysis. Predicted to act upstream of or within several processes, including mitochondrion organization; nervous system development; and righting reflex. Predicted to be located in mitochondrial inner membrane. Predicted to be part of m-AAA complex. Human ortholog(s) of this gene implicated in optic atrophy 12; spastic ataxia; spastic ataxia 5; and spinocerebellar ataxia type 28. Orthologous to human AFG3L2 (AFG3 like matrix AAA peptidase subunit 2); INTERACTS WITH 2,6-dinitrotoluene; 3-chloropropane-1,2-diol; 4-amino-2,6-dinitrotoluene.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

AFG3 ATPase family gene 3-like 2; AFG3 ATPase family gene 3-like 2 (S. cerevisiae); AFG3 ATPase family member 3-like 2; AFG3 ATPase family member 3-like 2 (S. cerevisiae); AFG3(ATPase family gene 3)-like 2; AFG3(ATPase family gene 3)-like 2 (yeast); AFG3-like AAA ATPase 2; AFG3-like protein 2; LOC307350; MGC109579

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	AFG3L2 (AFG3 like matrix AAA peptidase subunit 2)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Afg3l2 (AFG3-like AAA ATPase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Afg3l2 (AFG3 like matrix AAA peptidase subunit 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	AFG3L2 (AFG3 like matrix AAA peptidase subunit 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	AFG3L2 (AFG3 like matrix AAA peptidase subunit 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Afg3l2 (AFG3 like matrix AAA peptidase subunit 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	AFG3L2 (AFG3 like matrix AAA peptidase subunit 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	AFG3L2 (AFG3 like matrix AAA peptidase subunit 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Afg3l2 (AFG3 like matrix AAA peptidase subunit 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	AFG3L2 (AFG3 like matrix AAA peptidase subunit 2)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Afg3l2 (AFG3-like AAA ATPase 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	afg3l2 (AFG3-like AAA ATPase 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	AFG3	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG6512	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	spg-7	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	18	60,954,268 - 60,999,110 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	18	60,954,268 - 60,999,110 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	18	63,024,645 - 63,069,520 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	18	63,723,408 - 63,768,273 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	18	61,575,667 - 61,620,477 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	18	63,141,418 - 63,185,510 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	18	63,141,418 - 63,185,510 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	18	62,325,697 - 62,369,789 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	18	63,930,652 - 63,976,211 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	18	64,004,342 - 64,049,237 (-)	NCBI
Celera	18	59,060,862 - 59,105,674 (-)	NCBI		Celera
Cytogenetic Map	18	q12.1	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autosomal dominant cerebellar ataxia (ISO)

chromosome 18p deletion syndrome (ISO)

dystonia (ISO)

genetic disease (ISO)

intellectual disability (ISO)

optic atrophy (ISO)

optic atrophy 12 (ISO)

progressive myoclonus epilepsy (ISO)

sensorineural hearing loss (ISO)

spastic ataxia (ISO)

spastic ataxia 5 (ISO)

spinocerebellar ataxia type 28 (ISO,ISS)

Spinocerebellar Ataxias (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

1,2-dimethylhydrazine (ISO)

2,3',4,4',5-Pentachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,6-dinitrotoluene (EXP)

2-methylcholine (ISO)

3,3',4,4'-tetrachlorobiphenyl (ISO)

3,4-methylenedioxymethamphetamine (ISO)

3-chloropropane-1,2-diol (EXP)

3-isobutyl-1-methyl-7H-xanthine (ISO)

4,4'-sulfonyldiphenol (ISO)

4-amino-2,6-dinitrotoluene (EXP)

all-trans-retinoic acid (ISO)

apigenin (ISO)

Aroclor 1254 (ISO)

atrazine (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

Bisphenol B (ISO)

bisphenol F (ISO)

cobalt dichloride (EXP)

dexamethasone (ISO)

doxorubicin (ISO)

endosulfan (EXP)

epoxiconazole (ISO)

ethanol (ISO)

flutamide (EXP)

folic acid (ISO)

hydralazine (ISO)

indometacin (ISO)

ivermectin (ISO)

maneb (ISO)

nefazodone (EXP)

paracetamol (ISO)

paraquat (ISO)

perfluorooctane-1-sulfonic acid (ISO)

pirinixic acid (ISO)

resveratrol (ISO)

thioacetamide (EXP)

trichostatin A (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

axonogenesis (ISO)

biological_process (ND)

calcium import into the mitochondrion (ISO)

cristae formation (ISO)

membrane protein proteolysis (ISO)

mitochondrial calcium ion homeostasis (ISO)

mitochondrial fusion (ISO)

mitochondrial protein processing (IBA,ISO)

mitochondrion organization (ISO)

muscle cell development (ISO)

myelination (ISO)

nerve development (ISO)

neuromuscular junction development (ISO)

protein autoprocessing (ISO)

protein processing (ISO)

proteolysis (ISO)

regulation of multicellular organism growth (ISO)

righting reflex (ISO)

Cellular Component

m-AAA complex (IBA,ISO)

mitochondrial inner membrane (ISO)

mitochondrion (ISO)

Molecular Function

ATP binding (IEA)

ATP hydrolysis activity (IEA)

ATP-dependent peptidase activity (IEA)

metalloendopeptidase activity (IBA,ISO)

metallopeptidase activity (ISO)

protein binding (ISO)

zinc ion binding (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	StAR enhances transcription of genes encoding the mitochondrial proteases involved in its own degradation.	Bahat A, etal., Mol Endocrinol. 2014 Feb;28(2):208-24. doi: 10.1210/me.2013-1275. Epub 2013 Jan 1.
2.	Missense mutations in the AFG3L2 proteolytic domain account for approximately 1.5% of European autosomal dominant cerebellar ataxias.	Cagnoli C, etal., Hum Mutat. 2010 Oct;31(10):1117-24. doi: 10.1002/humu.21342.
3.	Mutations in the mitochondrial protease gene AFG3L2 cause dominant hereditary ataxia SCA28.	Di Bella D, etal., Nat Genet. 2010 Apr;42(4):313-21. doi: 10.1038/ng.544. Epub 2010 Mar 7.
4.	Early onset and slow progression of SCA28, a rare dominant ataxia in a large four-generation family with a novel AFG3L2 mutation.	Edener U, etal., Eur J Hum Genet. 2010 Aug;18(8):965-8. doi: 10.1038/ejhg.2010.40. Epub 2010 Mar 31.
5.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
7.	Purkinje neuron Ca2+ influx reduction rescues ataxia in SCA28 model.	Maltecca F, etal., J Clin Invest. 2015 Jan;125(1):263-74. doi: 10.1172/JCI74770. Epub 2014 Dec 8.
8.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
9.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
10.	Whole-exome sequencing identifies homozygous AFG3L2 mutations in a spastic ataxia-neuropathy syndrome linked to mitochondrial m-AAA proteases.	Pierson TM, etal., PLoS Genet. 2011 Oct;7(10):e1002325. doi: 10.1371/journal.pgen.1002325. Epub 2011 Oct 13.
11.	GOA pipeline	RGD automated data pipeline
12.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
14.	Comprehensive gene review and curation	RGD comprehensive gene curation
15.	Partial deletion of AFG3L2 causing spinocerebellar ataxia type 28.	Smets K, etal., Neurology. 2014 Jun 10;82(23):2092-100. doi: 10.1212/WNL.0000000000000491. Epub 2014 May 9.
16.	SCA28: Novel Mutation in the AFG3L2 Proteolytic Domain Causes a Mild Cerebellar Syndrome with Selective Type-1 Muscle Fiber Atrophy.	Svenstrup K, etal., Cerebellum. 2016 Feb 11.

Additional References at PubMed

PMID:2917690	PMID:12477932	PMID:12865426	PMID:18614015	PMID:19656850	PMID:20038678	PMID:22354088	PMID:27642048	PMID:36786711

Genomics

Comparative Map Data

Afg3l2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	18	60,954,268 - 60,999,110 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	18	60,954,268 - 60,999,110 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	18	63,024,645 - 63,069,520 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	18	63,723,408 - 63,768,273 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	18	61,575,667 - 61,620,477 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	18	63,141,418 - 63,185,510 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	18	63,141,418 - 63,185,510 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	18	62,325,697 - 62,369,789 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	18	63,930,652 - 63,976,211 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	18	64,004,342 - 64,049,237 (-)	NCBI
Celera	18	59,060,862 - 59,105,674 (-)	NCBI		Celera
Cytogenetic Map	18	q12.1	NCBI

AFG3L2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	18	12,328,944 - 12,377,227 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	18	12,328,944 - 12,377,227 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	18	12,328,943 - 12,377,226 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	18	12,319,108 - 12,367,194 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	18	12,319,107 - 12,367,194	NCBI
Celera	18	12,209,592 - 12,258,040 (-)	NCBI		Celera
Cytogenetic Map	18	p11.21	NCBI
HuRef	18	12,282,720 - 12,330,985 (-)	NCBI		HuRef
CHM1_1	18	12,328,344 - 12,376,662 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	18	12,491,960 - 12,540,204 (-)	NCBI		T2T-CHM13v2.0

Afg3l2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	18	67,537,830 - 67,582,277 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	18	67,537,834 - 67,582,242 (-)	Ensembl		GRCm39 Ensembl
GRCm38	18	67,404,764 - 67,449,192 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	18	67,404,764 - 67,449,172 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	18	67,564,418 - 67,608,790 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	18	67,530,647 - 67,573,748 (-)	NCBI		MGSCv36	mm8
MGSCv36	18	67,744,570 - 67,787,917 (-)	NCBI		MGSCv36	mm8
Celera	18	68,681,846 - 68,732,097 (-)	NCBI		Celera
Cytogenetic Map	18	E1	NCBI
cM Map	18	39.96	NCBI

Afg3l2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955402	1,037,402 - 1,069,165 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955402	1,037,414 - 1,069,165 (+)	NCBI	ChiLan1.0	ChiLan1.0

AFG3L2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	18	11,361,288 - 11,409,633 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	18	1,951,279 - 1,999,313 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	18	17,062,250 - 17,109,400 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	18	17,062,250 - 17,109,400 (+)	Ensembl	panpan1.1		panPan2

AFG3L2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	7	77,749,029 - 77,787,466 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	7	77,737,808 - 77,787,472 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	7	77,150,018 - 77,188,528 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	7	77,807,611 - 77,846,122 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	7	77,807,620 - 77,846,169 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	7	77,504,323 - 77,543,062 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	7	77,551,535 - 77,590,352 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	7	77,837,991 - 77,876,512 (-)	NCBI		UU_Cfam_GSD_1.0

Afg3l2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404944	922,646 - 961,521 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936626	150,974 - 189,218 (+)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936626	150,953 - 189,980 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

AFG3L2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	97,200,922 - 97,235,366 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	6	97,200,890 - 97,234,577 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	90,816,080 - 90,833,767 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

AFG3L2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	18	70,890,939 - 70,939,504 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	18	70,891,554 - 70,939,352 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666050	45,917,807 - 45,966,505 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Afg3l2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624770	19,591,215 - 19,631,722 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624770	19,590,829 - 19,631,663 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Afg3l2
171 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	70
Count of miRNA genes:	65
Interacting mature miRNAs:	67
Transcripts:	ENSRNOT00000024632
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2293708	Bss46	Bone structure and strength QTL 46	8.8	0.0001	lumbar vertebra morphology trait (VT:0010494)	lumbar vertebra cortical cross-sectional area (CMO:0001690)	18	11791518	63636873	Rat
1578661	Bss20	Bone structure and strength QTL 20	3.7		femur morphology trait (VT:0000559)	femoral neck cross-sectional area (CMO:0001697)	18	11791518	83218561	Rat
1578667	Bss21	Bone structure and strength QTL 21	3.5		femur morphology trait (VT:0000559)	femoral neck cortical cross-sectional area (CMO:0001702)	18	11791518	83218561	Rat
1358193	Emca2	Estrogen-induced mammary cancer QTL 2	1.6		mammary gland integrity trait (VT:0010552)	post-insult time to mammary tumor formation (CMO:0000345)	18	18007599	63571040	Rat
1600373	Mamtr6	Mammary tumor resistance QTL 6			mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	18	19278901	83218561	Rat
1331741	Bp232	Blood pressure QTL 232	3.59112		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	18	21372893	83213037	Rat
1331733	Bp233	Blood pressure QTL 233	3.97196		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	24796977	79788953	Rat
2325839	Bp348	Blood pressure QTL 348		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	25570985	70570985	Rat
2293704	Bss35	Bone structure and strength QTL 35	4.59	0.0002	femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	18	28964853	73964853	Rat
2300157	Bmd66	Bone mineral density QTL 66	13.1	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	18	28964853	73964853	Rat
2300177	Bmd65	Bone mineral density QTL 65	19.7	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	18	28964853	73964853	Rat
9589816	Gluco68	Glucose level QTL 68	7.25	0.001	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	18	29792965	74792965	Rat
8694378	Bw157	Body weight QTL 157	3.59	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	18	29792965	74792965	Rat
9590318	Scort22	Serum corticosterone level QTL 22	7.64	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	18	29792965	74792965	Rat
1331754	Bp230	Blood pressure QTL 230	4.61609		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	29792965	74792965	Rat
738005	Anxrr11	Anxiety related response QTL 11	3.4		exploratory behavior trait (VT:0010471)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	18	30039813	75039813	Rat
1331727	Bp237	Blood pressure QTL 237	3.053		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	31359408	61698465	Rat
61429	Cia17	Collagen induced arthritis QTL 17	4.6		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	18	31359408	70263868	Rat
2303120	Mamtr8	Mammary tumor resistance QTL 8		0.001	mammary gland integrity trait (VT:0010552)	mammary tumor growth rate (CMO:0000344)	18	31359408	83218561	Rat
631274	Sprol1	Serum protein level QTL 1	5.3		blood total protein amount (VT:0005567)	serum total protein level (CMO:0000661)	18	31393320	77209694	Rat
631518	Bw11	Body weight QTL 11	2.8		body mass (VT:0001259)	body weight (CMO:0000012)	18	35870723	80870723	Rat
61367	Iddm4	Insulin dependent diabetes mellitus QTL 4	2.33	0.0074	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	18	38192455	83192455	Rat
1598826	Anxrr20	Anxiety related response QTL 20	3.04		body movement coordination trait (VT:0005424)	number of rearing movements in an experimental apparatus (CMO:0001752)	18	41432971	83828827	Rat
6893683	Bw110	Body weight QTL 110	2.7	0.002	body mass (VT:0001259)	body weight (CMO:0000012)	18	43345022	83828827	Rat
8694366	Abfw8	Abdominal fat weight QTL 8	6.38	0.001	visceral adipose mass (VT:0010063)	abdominal fat pad weight to body weight ratio (CMO:0000095)	18	46640675	83828827	Rat
8694432	Bw165	Body weight QTL 165	3.81	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	18	46640675	83828827	Rat
9589041	Epfw12	Epididymal fat weight QTL 12	17.08	0.001	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	18	46640675	83828827	Rat
2303571	Bw92	Body weight QTL 92	3		body mass (VT:0001259)	body weight (CMO:0000012)	18	48520044	83828827	Rat
2303584	Gluco55	Glucose level QTL 55	2		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	18	48520044	83828827	Rat
7411719	Strs5	Sensitivity to stroke QTL 5	9.4		cerebrum integrity trait (VT:0010549)	percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)	18	49999958	65845095	Rat
2293658	Bmd23	Bone mineral density QTL 23	7.3	0.0001	femur mineral mass (VT:0010011)	total volumetric bone mineral density (CMO:0001728)	18	51464733	63636873	Rat
738008	Hcar14	Hepatocarcinoma resistance QTL 14	4.3		liver integrity trait (VT:0010547)	liver nonremodeling tumorous lesion number (CMO:0001462)	18	51464733	83218561	Rat
1331752	Bw27	Body weight QTL 27	2.963		body mass (VT:0001259)	body weight (CMO:0000012)	18	52292875	65845095	Rat
1359020	Ppulsi2	Prepulse inhibition QTL 2	2.71		prepulse inhibition trait (VT:0003088)	acoustic startle response measurement (CMO:0001519)	18	52292875	73997283	Rat
1600375	Mcs22	Mammary carcinoma susceptibility QTL 22	3.3		mammary gland integrity trait (VT:0010552)	mammary tumor growth rate (CMO:0000344)	18	52539763	63933058	Rat
631509	Sald2	Serum aldosterone level QTL 2	2.9		blood aldosterone amount (VT:0005346)	serum aldosterone level (CMO:0000487)	18	52539763	69140759	Rat
12880368	Bw187	Body weight QTL 187		0.045	body mass (VT:0001259)	body weight (CMO:0000012)	18	52539763	76104388	Rat
12904067	Cm122	Cardiac mass QTL 122		0.001	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	18	52539763	76104388	Rat
12904069	Cm123	Cardiac mass QTL 123		0.001	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	18	52539763	76104388	Rat
12904070	Cm124	Cardiac mass QTL 124		0.01	heart right ventricle mass (VT:0007033)	heart right ventricle weight to body weight ratio (CMO:0000914)	18	52539763	76104388	Rat
12904071	Am18	Aortic mass QTL 18		0.001	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	18	52539763	76104388	Rat
12904073	Kidm71	Kidney mass QTL 71		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	18	52539763	76104388	Rat
2301417	Bp319	Blood pressure QTL 319		0.002	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	52539763	76104388	Rat
1300125	Rf26	Renal function QTL 26	3.2		urine potassium amount (VT:0010539)	urine potassium excretion rate (CMO:0000761)	18	52539863	65844950	Rat
1298072	Cia26	Collagen induced arthritis QTL 26	3.6		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	18	54709769	83828827	Rat
631834	Sach3	Saccharin preference QTL 3	3.9	0.01	consumption behavior trait (VT:0002069)	calculated saccharin drink intake volume (CMO:0001600)	18	58805687	63636873	Rat
724542	Kidm2	Kidney mass QTL 2	2.6		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	18	59172115	83828827	Rat
2312600	Bp341	Blood pressure QTL 341		0.05	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	18	59330409	70263868	Rat
2301969	Bp324	Blood pressure QTL 324	4.05		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	18	59712417	76477814	Rat
70185	BpQTLcluster15	Blood pressure QTL cluster 15	4.61		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	18	59712417	76477814	Rat
70185	BpQTLcluster15	Blood pressure QTL cluster 15	4.61		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	59712417	76477814	Rat
70185	BpQTLcluster15	Blood pressure QTL cluster 15	4.61		arterial blood pressure trait (VT:2000000)	absolute change in mean arterial blood pressure (CMO:0000533)	18	59712417	76477814	Rat
70185	BpQTLcluster15	Blood pressure QTL cluster 15	4.61		arterial blood pressure trait (VT:2000000)	absolute change in systolic blood pressure (CMO:0000607)	18	59712417	76477814	Rat
1331770	Bp234	Blood pressure QTL 234	3.807		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	59796478	71893566	Rat
6903353	Bp353	Blood pressure QTL 353	2.8		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	18	59796478	83828827	Rat
6903356	Bp354	Blood pressure QTL 354	4.6		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	59796478	83828827	Rat
61384	Bp48	Blood pressure QTL 48	19.4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	18	60622311	77209844	Rat
631675	Iddm15	Insulin dependent diabetes mellitus QTL 15			urine glucose amount (VT:0001758)	percentage of study population developing diabetes mellitus during a period of time (CMO:0001114)	18	60622311	77209844	Rat

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	43	57	41	19	41	8	11	74	35	40	11	8
Low											1
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001134864	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039096796	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039096797	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC091419	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473971	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000301	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000024632 ⟹ ENSRNOP00000024632

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	18	60,954,268 - 60,999,110 (-)	Ensembl
Rnor_6.0 Ensembl	18	63,141,418 - 63,185,510 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000102128 ⟹ ENSRNOP00000078320

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	18	60,954,268 - 60,995,289 (-)	Ensembl

RefSeq Acc Id:

NM_001134864 ⟹ NP_001128336

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	18	60,954,268 - 60,999,110 (-)	NCBI
Rnor_6.0	18	63,141,418 - 63,185,510 (-)	NCBI
Rnor_5.0	18	62,325,697 - 62,369,789 (-)	NCBI
RGSC_v3.4	18	63,930,652 - 63,976,211 (-)	RGD
Celera	18	59,060,862 - 59,105,674 (-)	RGD

Sequence:

show sequence

GTCCGCACGCTGGGGCGGGGCCTGACGAGCGCGCGTGGAGCGTGGGTTCGCGTTCTGCCGCGGG
TCTCCTGCGCCGGTGGCGCGCAGCTCCCGGATAAGTTGCGGAAGCTGAGGGTTGCCGACCGCCG
GCTTTGGCTCGGTCCCTGCGCGCGCCCCGGAGCGGGCCGGGCCCATCATGGCTCACCGCTGCCT
GCTGCTGTGGGGTCGGGGCGGCTGCCGTCGCGGCCTTCCTCCCCTGCTCGTGCCCAGCGGCTGC
CTGGGTCCCGGCCGGCGGCCCTGCCTCCGTACGCTTTATCAGTACGCTACGGTCCAAACAGCAA
ACAGCAGAAGTTCTCTTCTAAGGGATGTAATTGCTGCTTATCAAAGATTCTGTTCTCGACCTCC
CAAAGGATTTGAAAAATACTTTCCTAATGGGAAAAATGGAAAAAAGGCCAGCGAATCTAAGGAA
GCTGTTGGAGAAAAAAAAGAATCACAACTCTCCGGTCCCCAGTCTTCTGGAGGTGCAAGTGGTG
GGGGAGGGAAGCGCCGTGGCAAGAAAGAAGATTCTCACTGGTGGTCCAGGTTCCAGAAGGGTGA
CTTTCCATGGGATGACAAGGATTTCAGGATGTACTTTCTCTGGACTGCTCTTTTTTGGAGTGGA
GTCATGATTTACTTCCTGTTCAAGAGCTCTGGGAGAGAAATCACATGGAAAGACTTTGTCAATA
ACTATCTTTCTAAAGGAGTGGTGGACAGACTAGAAGTTGTCAACAAACGTTTTGTTCGTGTGAC
CTTTACTCCAGGAAAAACTCCAGTTGATGGGCAATACGTCTGGTTTAATATTGGCAGTGTTGAC
ACATTTGAGCGGAATCTGGAGACTTTGCAGCAAGAATTGGGCATAGAAGGGGAGAACCGGGTGC
CTGTGGTTTACATTGCTGAAAGCGATGGCTCCTTCCTGCTGAGCATGTTGCCCACGGTACTCAT
TATTGCTTTTCTACTCTACACCATAAGAAGAGGGCCCGCTGGCATTGGTCGGACCGGTCGGGGA
ATGGGTGGACTCTTCAGTGTTGGGGAAACGACAGCCAAGGTCTTAAAGGATGAGATAGATGTGA
AGTTTAAAGATGTGGCTGGCTGTGAGGAGGCCAAGCTAGAAATAATGGAATTTGTGAATTTCTT
GAAAAATCCAAAGCAGTATCAAGACCTAGGAGCAAAAATCCCAAAGGGTGCCATTCTCACTGGT
CCCCCAGGTACTGGGAAGACACTGCTAGCTAAGGCCACAGCTGGAGAAGCCAATGTCCCCTTCA
TCACTGTCAGTGGATCTGAGTTTCTGGAGATGTTTGTCGGTGTTGGTCCAGCCAGGGTCCGAGA
CTTATTTGCCCTTGCACGGAAGAATGCTCCTTGCATTCTCTTCATTGACGAGATTGATGCTGTG
GGAAGGAAGCGTGGTAGAGGCAACTTTGGAGGACAGAGTGAGCAGGAGAACACACTCAATCAGC
TGCTCGTGGAGATGGACGGCTTCAACACCACCACCAACGTGGTCATCCTGGCAGGCACAAATCG
ACCAGACATCCTTGATCCAGCTCTGCTGAGACCAGGCCGCTTTGACAGGCAGATCTTCATTGGA
CCCCCAGACATAAAAGGACGAGCTTCAATCTTCAAAGTTCACCTTCGACCATTGAAACTAGACA
GTGCCTTGGAAAAAGATAAATTGGCCAGAAAACTGGCGTCCTTGACTCCAGGGTTTTCAGGCGC
TGATGTTGCCAATGTCTGTAATGAAGCTGCTTTGATTGCTGCCAGACACCTTTCAGATGCCATT
AACGAGAAGCACTTCGAACAAGCGATTGAGCGAGTGATTGGAGGCTTGGAGAAAAAAACCCAAG
TTCTGCAACCCGAGGAGAAGAAGACTGTGGCTTACCACGAAGCAGGCCACGCAGTCGCCGGCTG
GTATCTGGAGCATGCAGACCCACTCTTAAAGGTGTCCATCATCCCGCGTGGAAAGGGGCTGGGC
TATGCTCAGTACTTGCCCAAGGAGCAGTATCTGTACACAAAGGAGCAGCTGCTGGACAGGATGT
GCATGACTCTGGGTGGCCGTGTCTCCGAGGAGATCTTCTTTGGAAGAATTACGACCGGTGCCCA
GGATGACTTGAGGAAGGTTACCCAGAGTGCCTATGCCCAGATTGTTCAGTTTGGCATGAATGAG
AAAGTGGGGCAGATCTCCTTTGACCTCCCACGACAGGGGGACATGGTATTAGAGAAGCCTTACA
GTGAAGCCACTGCAAGAATGATAGACGATGAAGTGAGGATACTCATTAGTGAAGCCTATAAAAG
AACTGTGGCTCTTCTCACAGAGAAGAAGGCTGACGTGGAGAAGGTTGCTCTCCTACTGTTAGAG
AAAGAAGTATTAGACAAGAACGACATGGTTGAACTTCTGGGTCCCAGACCATTTACAGAAAAAT
CCACATATGAAGAATTTGTGGAAGGCACTGGCAGCTTAGATGAGGACACTTCTCTTCCTGAAGG
CCTTCAGGATTGGAACAAGGAGCGGGAGAAGGAGAAGAAGGAGAAGAAGGAGAAGGAGGAGCCC
GTGAATGAGAAGGTGGTCAGCTAGGCTCTCCCAGGGCTGGAGGCCCATTTACCTTCCCCTCTCG
GGCCGTCAGAACAGCAGCCCTGATGCAGCCCGCTGCTGACTCAGCCAGGCTGAGGACGGCCTCC
ACTGAGCTGCAGTGTCAGCACTGCCCGCCCTCAGCCTGGCCTCACGAACACTGGCTGGAACAGG
AGAGACAGCACCACCTGCCATCGCCTGTCCCGTGGACTCTATCACGAGGGAGAAGACTCTTCCC
ATCGATGGCCCTCTTCAGTCCTCTTCCTGCGATATCTCTGCAGGAGTGCTGTGAAATTCGGTTG
GAGTCCTGATGAGAATATTTTGATTCAACCAAATATTTTCAAATTTGAATTCAGATCACTCGTT
GATGTTTTAATGGAGTGGTTTTCTATAGAGAACTGTAACATATTTAAAAACATGAATGTATTGT
GTAAATATGGATTCTTTACATTAGAAATAAAAGGTGGACATTGTACTTTTTTCCTGAGCATATG
AA

hide sequence

RefSeq Acc Id:

XM_039096796 ⟹ XP_038952724

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	18	60,954,274 - 60,994,515 (-)	NCBI

RefSeq Acc Id:

XM_039096797 ⟹ XP_038952725

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	18	60,954,274 - 60,982,739 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001128336	(Get FASTA)	NCBI Sequence Viewer
	XP_038952724	(Get FASTA)	NCBI Sequence Viewer
	XP_038952725	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH91419	(Get FASTA)	NCBI Sequence Viewer
	EDM14729	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_001128336 ⟸ NM_001134864

- UniProtKB:

F1LN92 (UniProtKB/TrEMBL), A0A8I5ZLF3 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MAHRCLLLWGRGGCRRGLPPLLVPSGCLGPGRRPCLRTLYQYATVQTANSRSSLLRDVIAAYQR
FCSRPPKGFEKYFPNGKNGKKASESKEAVGEKKESQLSGPQSSGGASGGGGKRRGKKEDSHWWS
RFQKGDFPWDDKDFRMYFLWTALFWSGVMIYFLFKSSGREITWKDFVNNYLSKGVVDRLEVVNK
RFVRVTFTPGKTPVDGQYVWFNIGSVDTFERNLETLQQELGIEGENRVPVVYIAESDGSFLLSM
LPTVLIIAFLLYTIRRGPAGIGRTGRGMGGLFSVGETTAKVLKDEIDVKFKDVAGCEEAKLEIM
EFVNFLKNPKQYQDLGAKIPKGAILTGPPGTGKTLLAKATAGEANVPFITVSGSEFLEMFVGVG
PARVRDLFALARKNAPCILFIDEIDAVGRKRGRGNFGGQSEQENTLNQLLVEMDGFNTTTNVVI
LAGTNRPDILDPALLRPGRFDRQIFIGPPDIKGRASIFKVHLRPLKLDSALEKDKLARKLASLT
PGFSGADVANVCNEAALIAARHLSDAINEKHFEQAIERVIGGLEKKTQVLQPEEKKTVAYHEAG
HAVAGWYLEHADPLLKVSIIPRGKGLGYAQYLPKEQYLYTKEQLLDRMCMTLGGRVSEEIFFGR
ITTGAQDDLRKVTQSAYAQIVQFGMNEKVGQISFDLPRQGDMVLEKPYSEATARMIDDEVRILI
SEAYKRTVALLTEKKADVEKVALLLLEKEVLDKNDMVELLGPRPFTEKSTYEEFVEGTGSLDED
TSLPEGLQDWNKEREKEKKEKKEKEEPVNEKVVS

hide sequence

RefSeq Acc Id:

ENSRNOP00000024632 ⟸ ENSRNOT00000024632

RefSeq Acc Id:	XP_038952724 ⟸ XM_039096796
- Peptide Label:	isoform X1
- UniProtKB:	A0A8I5ZLF3 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038952725 ⟸ XM_039096797
- Peptide Label:	isoform X2

RefSeq Acc Id:

ENSRNOP00000078320 ⟸ ENSRNOT00000102128

Protein Domains

AAA+ ATPase Peptidase M41

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-F1LN92-F1-model_v2	AlphaFold	F1LN92	1-802	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1305259	AgrOrtholog
BioCyc Gene	G2FUF-7143	BioCyc
Ensembl Genes	ENSRNOG00000017965	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000024632	ENTREZGENE
	ENSRNOP00000024632.4	UniProtKB/TrEMBL
	ENSRNOP00000078320.1	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000024632	ENTREZGENE
	ENSRNOT00000024632.6	UniProtKB/TrEMBL
	ENSRNOT00000102128.1	UniProtKB/TrEMBL
Gene3D-CATH	1.10.8.60	UniProtKB/TrEMBL
	1.20.58.760	UniProtKB/TrEMBL
	3.40.1690.20	UniProtKB/TrEMBL
	3.40.50.300	UniProtKB/TrEMBL
InterPro	AAA+_ATPase	UniProtKB/TrEMBL
	AAA_lid_3	UniProtKB/TrEMBL
	ATPase_AAA_core	UniProtKB/TrEMBL
	ATPase_AAA_CS	UniProtKB/TrEMBL
	FtsH	UniProtKB/TrEMBL
	P-loop_NTPase	UniProtKB/TrEMBL
	Pept_M41_FtsH_extracell	UniProtKB/TrEMBL
	Peptidase_M41	UniProtKB/TrEMBL
	Peptidase_M41-like	UniProtKB/TrEMBL
KEGG Report	rno:307350	UniProtKB/TrEMBL
NCBI Gene	307350	ENTREZGENE
PANTHER	AFG3-LIKE PROTEIN 2	UniProtKB/TrEMBL
	ATP-DEPENDENT PROTEASE	UniProtKB/TrEMBL
Pfam	AAA	UniProtKB/TrEMBL
	AAA_lid_3	UniProtKB/TrEMBL
	FtsH_ext	UniProtKB/TrEMBL
	Peptidase_M41	UniProtKB/TrEMBL
PhenoGen	Afg3l2	PhenoGen
PROSITE	AAA	UniProtKB/TrEMBL
SMART	AAA	UniProtKB/TrEMBL
Superfamily-SCOP	SSF140990	UniProtKB/TrEMBL
	SSF52540	UniProtKB/TrEMBL
UniProt	A0A8I5ZLF3	ENTREZGENE, UniProtKB/TrEMBL
	A6IXU8_RAT	UniProtKB/TrEMBL
	F1LN92	ENTREZGENE, UniProtKB/TrEMBL
	Q5BJM6_RAT	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-03-01	Afg3l2	AFG3 like matrix AAA peptidase subunit 2	Afg3l2	AFG3-like AAA ATPase 2	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2013-11-11	Afg3l2	AFG3-like AAA ATPase 2	Afg3l2	AFG3 ATPase family member 3-like 2 (S. cerevisiae)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2012-11-21	Afg3l2	AFG3 ATPase family member 3-like 2 (S. cerevisiae)	Afg3l2	AFG3 ATPase family gene 3-like 2 (S. cerevisiae)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2011-07-28	Afg3l2	AFG3 ATPase family gene 3-like 2 (S. cerevisiae)	Afg3l2	AFG3(ATPase family gene 3)-like 2 (yeast)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-12-06	Afg3l2	AFG3(ATPase family gene 3)-like 2 (yeast)	Afg3l2_predicted	AFG3(ATPase family gene 3)-like 2 (yeast) (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-12	Afg3l2_predicted	AFG3(ATPase family gene 3)-like 2 (yeast) (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

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Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

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MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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