Als2cl (ALS2 C-terminal like) - Rat Genome Database

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Pathways
Gene: Als2cl (ALS2 C-terminal like) Rattus norvegicus
Analyze
Symbol: Als2cl
Name: ALS2 C-terminal like
RGD ID: 1305208
Description: Predicted to enable guanyl-nucleotide exchange factor activity and small GTPase binding activity. Predicted to be involved in endosomal transport. Predicted to act upstream of or within intracellular protein localization. Predicted to be active in cytoplasmic vesicle. Orthologous to human ALS2CL (ALS2 C-terminal like); INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; bisphenol A; bromobenzene.
Type: protein-coding
RefSeq Status: MODEL
Previously known as: ALS2 C-terminal-like protein; LOC316017; RGD1305208; similar to RN49018
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88119,746,498 - 119,762,824 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl8119,743,248 - 119,762,843 (+)EnsemblGRCr8
mRatBN7.28110,863,753 - 110,884,434 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8110,864,975 - 110,884,419 (+)EnsemblmRatBN7.2
Rnor_6.08119,156,081 - 119,176,680 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8119,160,731 - 119,174,830 (+)Ensemblrn6Rnor6.0
Rnor_5.08118,494,443 - 118,515,055 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.48115,269,448 - 115,287,976 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera8110,146,276 - 110,166,876 (+)NCBICelera
RGSC_v3.18115,288,197 - 115,306,337 (+)NCBI
Cytogenetic Map8q32NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA,IEA)
cytoplasmic vesicle  (IBA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:15388334   PMID:17239822  


Genomics

Comparative Map Data
Als2cl
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88119,746,498 - 119,762,824 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl8119,743,248 - 119,762,843 (+)EnsemblGRCr8
mRatBN7.28110,863,753 - 110,884,434 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8110,864,975 - 110,884,419 (+)EnsemblmRatBN7.2
Rnor_6.08119,156,081 - 119,176,680 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8119,160,731 - 119,174,830 (+)Ensemblrn6Rnor6.0
Rnor_5.08118,494,443 - 118,515,055 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.48115,269,448 - 115,287,976 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera8110,146,276 - 110,166,876 (+)NCBICelera
RGSC_v3.18115,288,197 - 115,306,337 (+)NCBI
Cytogenetic Map8q32NCBI
ALS2CL
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38346,668,995 - 46,693,679 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl346,668,994 - 46,694,071 (-)Ensemblhg38GRCh38
GRCh37346,710,485 - 46,735,169 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36346,685,683 - 46,710,175 (-)NCBIBuild 36Build 36hg18NCBI36
Celera346,648,229 - 46,672,945 (-)NCBICelera
Cytogenetic Map3p21.31NCBI
HuRef346,753,355 - 46,778,070 (-)NCBIHuRef
CHM1_1346,660,601 - 46,685,310 (-)NCBICHM1_1
T2T-CHM13v2.0346,685,103 - 46,709,793 (-)NCBIT2T-CHM13v2.0
Als2cl
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399110,709,203 - 110,729,598 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9110,708,938 - 110,729,598 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm389110,880,120 - 110,900,530 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9110,879,870 - 110,900,530 (+)Ensemblmm10GRCm38
MGSCv379110,782,678 - 110,803,034 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv369110,724,990 - 110,745,340 (+)NCBIMGSCv36mm8
Celera9110,606,134 - 110,626,473 (+)NCBICelera
Cytogenetic Map9F2NCBI
cM Map960.79NCBI
Als2cl
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495542025,440,641 - 25,455,872 (+)NCBIChiLan1.0ChiLan1.0
ALS2CL
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2246,626,013 - 46,649,108 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1346,630,748 - 46,653,872 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0346,568,200 - 46,591,331 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1347,671,265 - 47,695,772 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl347,671,286 - 47,695,772 (-)EnsemblpanPan2panpan1.1
ALS2CL
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12042,067,018 - 42,091,125 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2042,066,833 - 42,088,321 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2041,982,917 - 42,007,069 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02042,549,320 - 42,573,473 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2042,541,177 - 42,570,324 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12041,790,574 - 41,811,579 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02042,191,649 - 42,212,661 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02042,472,701 - 42,493,718 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Als2cl
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118200,956,940 - 200,976,633 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936596506,077 - 525,746 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936596506,088 - 525,576 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ALS2CL
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1329,596,700 - 29,618,919 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11329,596,696 - 29,618,915 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21332,829,891 - 32,901,030 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ALS2CL
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1228,093,439 - 8,116,940 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl228,091,528 - 8,110,881 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666041159,033,261 - 159,058,130 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Als2cl
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473074,509,658 - 74,525,221 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Als2cl
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v18101,465,833 - 101,481,930 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Als2cl
57 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:202
Count of miRNA genes:81
Interacting mature miRNAs:84
Transcripts:ENSRNOT00000046745, ENSRNOT00000049210
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303171Bp331Blood pressure QTL 3315.570.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)8105462581132782436Rat
1549909Stresp11Stress response QTL 116.830.0019stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)882352698127352698Rat
631210Bw3Body weight QTL35.9mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)861019838121662124Rat
9590292Uminl3Urine mineral level QTL 33.620.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)880768445125768445Rat
8694446Bw170Body weight QTL 17012.070.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)880768445125768445Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)870041301121080908Rat
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)868690349119799881Rat
10450865Bw175Body weight QTL 1754.1total fat pad mass (VT:0015008)adipose tissue molecular composition measurement (CMO:0000484)884192326129192326Rat
738011Anxrr9Anxiety related response QTL 96.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)8102413464132782436Rat
724539Cm19Cardiac mass QTL 192.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)8103375781129871912Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)855428333127966348Rat
634332Pia18Pristane induced arthritis QTL 184joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)884192326132782436Rat
2300181Bmd55Bone mineral density QTL 555.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)885348065130348065Rat
1300171Bp184Blood pressure QTL 1843.66arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)879394435132782436Rat
2313400Anxrr25Anxiety related response QTL 25aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)898145073122898010Rat
8694200Abfw4Abdominal fat weight QTL 49.070.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)880768445125768445Rat
8694392Bw161Body weight QTL 1618.060.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)880768445125768445Rat
61437Cia6Collagen induced arthritis QTL 6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)891340911131690273Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 151 91 90 59 78 59 6 342 178 11 130 81 92 31 9 9

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_001076120 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006226582 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006226584 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006226585 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006226586 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006226589 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008757871 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008766654 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017603722 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039082651 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039082659 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039082661 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039082662 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039082663 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039082664 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005488472 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005488473 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC114361 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473954 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000008 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000046745   ⟹   ENSRNOP00000043561
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl8119,743,248 - 119,762,843 (+)Ensembl
mRatBN7.2 Ensembl8110,864,975 - 110,884,419 (+)Ensembl
Rnor_6.0 Ensembl8119,160,731 - 119,174,830 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000107601   ⟹   ENSRNOP00000091022
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl8119,743,248 - 119,762,843 (+)Ensembl
mRatBN7.2 Ensembl8110,864,975 - 110,884,419 (+)Ensembl
RefSeq Acc Id: XM_039082651   ⟹   XP_038938579
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88119,746,498 - 119,762,824 (+)NCBI
mRatBN7.28110,868,083 - 110,884,434 (+)NCBI
RefSeq Acc Id: XM_039082659   ⟹   XP_038938587
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88119,746,859 - 119,757,729 (+)NCBI
mRatBN7.28110,864,808 - 110,879,315 (+)NCBI
RefSeq Acc Id: XM_039082661   ⟹   XP_038938589
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88119,746,859 - 119,757,193 (+)NCBI
mRatBN7.28110,864,808 - 110,878,777 (+)NCBI
RefSeq Acc Id: XM_039082662   ⟹   XP_038938590
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88119,746,859 - 119,755,779 (+)NCBI
mRatBN7.28110,864,808 - 110,877,362 (+)NCBI
RefSeq Acc Id: XM_039082663   ⟹   XP_038938591
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88119,752,011 - 119,762,824 (+)NCBI
mRatBN7.28110,873,595 - 110,884,434 (+)NCBI
RefSeq Acc Id: XM_039082664   ⟹   XP_038938592
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88119,746,859 - 119,755,457 (+)NCBI
mRatBN7.28110,864,808 - 110,877,041 (+)NCBI
RefSeq Acc Id: XR_005488472
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88119,746,859 - 119,760,543 (+)NCBI
mRatBN7.28110,864,808 - 110,882,128 (+)NCBI
RefSeq Acc Id: XR_005488473
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88119,746,859 - 119,756,627 (+)NCBI
mRatBN7.28110,864,808 - 110,878,211 (+)NCBI
Ensembl Acc Id: ENSRNOP00000043561   ⟸   ENSRNOT00000046745
RefSeq Acc Id: XP_038938587   ⟸   XM_039082659
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038938589   ⟸   XM_039082661
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038938590   ⟸   XM_039082662
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038938592   ⟸   XM_039082664
- Peptide Label: isoform X6
RefSeq Acc Id: XP_038938579   ⟸   XM_039082651
- Peptide Label: isoform X1
- UniProtKB: D3ZG75 (UniProtKB/TrEMBL),   A0A8I6AEV4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038938591   ⟸   XM_039082663
- Peptide Label: isoform X5
Ensembl Acc Id: ENSRNOP00000091022   ⟸   ENSRNOT00000107601
Protein Domains
VPS9

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZG75-F1-model_v2 AlphaFold D3ZG75 1-952 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1305208 AgrOrtholog
BioCyc Gene G2FUF-29044 BioCyc
Ensembl Genes ENSRNOG00000033921 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000046745 ENTREZGENE
  ENSRNOT00000046745.6 UniProtKB/TrEMBL
  ENSRNOT00000107601.2 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1050.80 UniProtKB/TrEMBL
  1.20.900.10 UniProtKB/TrEMBL
  Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain UniProtKB/TrEMBL
InterPro Alsin-like_PH UniProtKB/TrEMBL
  Alsin_GEFs/MotNeuronReg UniProtKB/TrEMBL
  DBL_dom_sf UniProtKB/TrEMBL
  MORN UniProtKB/TrEMBL
  VPS9 UniProtKB/TrEMBL
  VPS9_dom_sf UniProtKB/TrEMBL
NCBI Gene 316017 ENTREZGENE
PANTHER ALS2 C-TERMINAL-LIKE PROTEIN UniProtKB/TrEMBL
  ALSIN HOMOLOG UniProtKB/TrEMBL
Pfam MORN UniProtKB/TrEMBL
  PH_alsin UniProtKB/TrEMBL
  VPS9 UniProtKB/TrEMBL
PhenoGen Als2cl PhenoGen
PROSITE VPS9 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000033921 RatGTEx
SMART MORN UniProtKB/TrEMBL
Superfamily-SCOP Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain UniProtKB/TrEMBL
  SSF109993 UniProtKB/TrEMBL
  SSF48065 UniProtKB/TrEMBL
UniProt A0A8I6AEV4 ENTREZGENE, UniProtKB/TrEMBL
  D3ZG75 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-06 Als2cl  ALS2 C-terminal like  RGD1305208_predicted  similar to RN49018 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 RGD1305208_predicted  similar to RN49018 (predicted)  LOC316017_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC316017_predicted  similar to RN49018 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL