Meis2 (Meis homeobox 2) - Rat Genome Database

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Gene: Meis2 (Meis homeobox 2) Rattus norvegicus
Analyze
Symbol: Meis2
Name: Meis homeobox 2
RGD ID: 1305198
Description: Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in pancreas development; response to growth factor; and response to mechanical stimulus. Predicted to be located in nucleus. Biomarker of brain infarction. Human ortholog(s) of this gene implicated in cleft palate; cleft palate, cardiac defects, and intellectual disability; learning disability; open-angle glaucoma; and orofacial cleft. Orthologous to human MEIS2 (Meis homeobox 2); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: homeobox protein Meis2; LOC311311; Meis1, myeloid ecotropic viral integration site 1 homolog 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83123,197,066 - 123,399,002 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3123,197,066 - 123,397,751 (-)EnsemblGRCr8
mRatBN7.23102,742,904 - 102,944,833 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3102,742,900 - 102,949,696 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3106,398,249 - 106,600,359 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03114,997,287 - 115,199,382 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03112,659,875 - 112,860,693 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.03107,560,172 - 107,762,732 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3107,559,997 - 107,760,589 (-)Ensemblrn6Rnor6.0
Rnor_5.03114,124,722 - 114,327,367 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.43101,915,966 - 102,117,215 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera3101,688,008 - 101,887,707 (-)NCBICelera
RGSC_v3.13101,812,373 - 102,015,498 (-)NCBI
Cytogenetic Map3q35NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-methylcholine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
8'-apo-beta,psi-caroten-8'-al  (ISO)
9-cis-retinoic acid  (ISO)
aldrin  (ISO)
all-trans-4-oxoretinoic acid  (ISO)
all-trans-4-oxoretinol  (ISO)
all-trans-retinoic acid  (EXP,ISO)
all-trans-retinol  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
Benzo[k]fluoranthene  (ISO)
beta-carotene  (ISO)
beta-lapachone  (ISO)
bisphenol A  (EXP,ISO)
caffeine  (ISO)
captan  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (EXP)
cisplatin  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
diquat  (ISO)
disodium selenite  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
ethanol  (ISO)
fluoranthene  (ISO)
folic acid  (ISO)
folpet  (ISO)
fulvestrant  (ISO)
glyphosate  (EXP)
iron dichloride  (ISO)
leflunomide  (ISO)
lenalidomide  (ISO)
lipopolysaccharide  (ISO)
methimazole  (EXP)
methylmercury chloride  (ISO)
nickel atom  (ISO)
nickel sulfate  (ISO)
nitrogen dioxide  (ISO)
ozone  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
piroxicam  (ISO)
pomalidomide  (ISO)
potassium chromate  (ISO)
propiconazole  (EXP)
Ptaquiloside  (ISO)
quercetin  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
thalidomide  (ISO)
titanium dioxide  (ISO)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
nucleus  (IEA,ISO)

References

References - curated
# Reference Title Reference Citation
1. Neuronal replacement from endogenous precursors in the adult brain after stroke. Arvidsson A, etal., Nat Med. 2002 Sep;8(9):963-70. doi: 10.1038/nm747. Epub 2002 Aug 5.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Anterograde delivery of brain-derived neurotrophic factor to striatum via nigral transduction of recombinant adeno-associated virus increases neuronal death but promotes neurogenic response following stroke. Gustafsson E, etal., Eur J Neurosci. 2003 Jun;17(12):2667-78.
4. Haploinsufficiency of MEIS2 is associated with orofacial clefting and learning disability. Johansson S, etal., Am J Med Genet A. 2014 Jul;164A(7):1622-6. doi: 10.1002/ajmg.a.36498. Epub 2014 Mar 26.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Expression of stem cell markers and transcription factors during the remodeling of the rat pancreas after duct ligation. Peters K, etal., Virchows Arch. 2005 Jan;446(1):56-63. Epub 2004 Nov 30.
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Comprehensive gene review and curation RGD comprehensive gene curation
10. Genome-wide association study identifies seven novel susceptibility loci for primary open-angle glaucoma. Shiga Y, etal., Hum Mol Genet. 2018 Apr 15;27(8):1486-1496. doi: 10.1093/hmg/ddy053.
11. Meis2 represses the osteoblastic transdifferentiation of aortic valve interstitial cells through the Notch1/Twist1 pathway. Sun C, etal., Biochem Biophys Res Commun. 2019 Feb 5;509(2):455-461. doi: 10.1016/j.bbrc.2018.12.040. Epub 2018 Dec 26.
12. Expression of transcription factors and precursor cell markers during regeneration of beta cells in pancreata of rats treated with streptozotocin. Tiemann K, etal., Virchows Arch. 2007 Mar;450(3):261-6. Epub 2007 Jan 18.
13. Heterozygous loss-of-function variants of MEIS2 cause a triad of palatal defects, congenital heart defects, and intellectual disability. Verheije R, etal., Eur J Hum Genet. 2019 Feb;27(2):278-290. doi: 10.1038/s41431-018-0281-5. Epub 2018 Oct 5.
Additional References at PubMed
PMID:10764806   PMID:10842069   PMID:11279116   PMID:11358480   PMID:11438208   PMID:12183364   PMID:15465489   PMID:15617687   PMID:17049510   PMID:17178831   PMID:18787068   PMID:25834037  
PMID:26512644   PMID:26550823  


Genomics

Comparative Map Data
Meis2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83123,197,066 - 123,399,002 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3123,197,066 - 123,397,751 (-)EnsemblGRCr8
mRatBN7.23102,742,904 - 102,944,833 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3102,742,900 - 102,949,696 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3106,398,249 - 106,600,359 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03114,997,287 - 115,199,382 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03112,659,875 - 112,860,693 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.03107,560,172 - 107,762,732 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3107,559,997 - 107,760,589 (-)Ensemblrn6Rnor6.0
Rnor_5.03114,124,722 - 114,327,367 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.43101,915,966 - 102,117,215 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera3101,688,008 - 101,887,707 (-)NCBICelera
RGSC_v3.13101,812,373 - 102,015,498 (-)NCBI
Cytogenetic Map3q35NCBI
MEIS2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381536,889,204 - 37,101,311 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1536,889,204 - 37,101,299 (-)Ensemblhg38GRCh38
GRCh371537,181,405 - 37,393,512 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361534,970,524 - 35,180,792 (-)NCBIBuild 36Build 36hg18NCBI36
Celera1513,943,263 - 14,153,527 (-)NCBICelera
Cytogenetic Map15q14NCBI
HuRef1514,029,111 - 14,239,280 (-)NCBIHuRef
CHM1_11537,301,775 - 37,511,985 (-)NCBICHM1_1
T2T-CHM13v2.01534,694,657 - 34,906,720 (-)NCBIT2T-CHM13v2.0
Meis2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392115,691,745 - 115,897,925 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2115,693,545 - 115,896,320 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm382115,861,264 - 116,067,537 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2115,863,064 - 116,065,839 (-)Ensemblmm10GRCm38
MGSCv372115,687,000 - 115,890,794 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv362115,554,510 - 115,756,553 (-)NCBIMGSCv36mm8
Celera2117,003,666 - 117,210,747 (-)NCBICelera
Cytogenetic Map2E4- E5NCBI
cM Map258.28NCBI
Meis2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554164,101,977 - 4,311,791 (-)Ensembl
ChiLan1.0NW_0049554164,104,114 - 4,311,791 (-)NCBIChiLan1.0ChiLan1.0
MEIS2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21626,114,262 - 26,324,918 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11530,268,369 - 30,478,883 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01515,814,739 - 16,025,512 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11534,072,665 - 34,283,411 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1534,072,665 - 34,282,477 (-)EnsemblpanPan2panpan1.1
MEIS2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1304,422,451 - 4,627,277 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl304,422,440 - 4,741,335 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha304,476,676 - 4,681,235 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0304,544,212 - 4,749,027 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl304,544,217 - 4,749,667 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1304,471,642 - 4,676,294 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0304,569,335 - 4,774,290 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0304,703,783 - 4,908,705 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Meis2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864082,952,452 - 83,157,991 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936471798,739 - 1,006,047 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936471800,510 - 1,006,054 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MEIS2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1134,013,820 - 134,223,012 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11134,013,642 - 134,223,013 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21149,911,450 - 149,974,264 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MEIS2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12645,844,214 - 46,054,325 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604894,869,693 - 95,081,805 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Meis2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248044,210,770 - 4,413,261 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248044,210,765 - 4,413,284 (-)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Meis2
1138 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:97
Count of miRNA genes:84
Interacting mature miRNAs:89
Transcripts:ENSRNOT00000051638
Prediction methods:Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2301414Kidm37Kidney mass QTL 370.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)396509147141509147Rat
1582238Bw68Body weight QTL 683.20.0064body mass (VT:0001259)body weight (CMO:0000012)373592512136118980Rat
1582239Epfw1Epididymal fat weight QTL 14.50.0006epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)373592512136118980Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)351581665184004958Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)367641776167835660Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)358601291153936591Rat
1582216Bw65Body weight QTL 656.3body mass (VT:0001259)body weight (CMO:0000012)3122654702136118980Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)349872657138829559Rat
1582218Bw74Body weight QTL 743.90.0021body mass (VT:0001259)body weight (CMO:0000012)373592512136118980Rat
1582219Bw63Body weight QTL 633.80.001body mass (VT:0001259)body weight (CMO:0000012)3116582412136118980Rat
1582221Kidm30Kidney mass QTL 303.50.0008kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)385062224136118980Rat
1582210Bw71Body weight QTL 713.30.0012body mass (VT:0001259)body weight (CMO:0000012)385062224136118980Rat
7387306Bw124Body weight QTL 1243.20.0003body mass (VT:0001259)body weight (CMO:0000012)3104545086149545086Rat
1300111Rf12Renal function QTL 123.78renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)381425008141509147Rat
724523Tsu1Thymus enlargement suppressive QTL 13.84thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)370845569136091483Rat
1600376Arunc5Aerobic running capacity QTL 50.21exercise endurance trait (VT:0002332)longest distance run on treadmill (CMO:0001406)393829559138829559Rat
8694437Bw167Body weight QTL 16722.460.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)3112250810157250810Rat
2302273Gluco35Glucose level QTL 355.30.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)3101255536134750886Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)379649560177741895Rat
2292613Ept16Estrogen-induced pituitary tumorigenesis QTL 168.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)367641995130815812Rat
1581503Cm58Cardiac mass QTL 582.70.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)396509147141509147Rat
1354611Despr2Despair related QTL 23.030.0028locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)3117537367162537367Rat
631649Bp123Blood pressure QTL 1233.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3110225882155225882Rat
631200Cm25Cardiac mass QTL 254.80.0001heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)381541464126563126Rat
12879848Bw181Body weght QTL 1810.015body mass (VT:0001259)body weight (CMO:0000012)390755164141509147Rat
5686842Rf59Renal function QTL 59urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)3122395989167395989Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31141509147Rat
1354597Kidm13Kidney mass QTL 132.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)342158111124558371Rat
1581546Pur13Proteinuria QTL 132.930.0335urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)398651826167012663Rat
1354604Bw36Body weight QTL 362.9body mass (VT:0001259)body weight (CMO:0000012)342158111124558371Rat
1331758Bp207Blood pressure QTL 2072.848arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3110634702155634702Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35675975141509147Rat
1358186Ept2Estrogen-induced pituitary tumorigenesis QTL 28.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)367641995130815812Rat
724532Cm17Cardiac mass QTL 172heart mass (VT:0007028)calculated heart weight (CMO:0000073)3116188400161188400Rat

Markers in Region
D3Rat204  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr83123,215,338 - 123,215,601 (+)Marker Load Pipeline
mRatBN7.23102,761,177 - 102,761,440 (+)MAPPERmRatBN7.2
Rnor_6.03107,578,444 - 107,578,706NCBIRnor6.0
Rnor_5.03114,142,994 - 114,143,256UniSTSRnor5.0
RGSC_v3.43101,934,370 - 101,934,633RGDRGSC3.4
RGSC_v3.43101,934,371 - 101,934,633UniSTSRGSC3.4
Celera3101,706,233 - 101,706,473UniSTS
RGSC_v3.13101,830,703 - 101,831,085RGD
FHH x ACI Map358.3499UniSTS
FHH x ACI Map358.3499RGD
Cytogenetic Map3q35UniSTS
D3Got228  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23102,816,420 - 102,816,636 (+)MAPPERmRatBN7.2
Rnor_6.03107,633,685 - 107,633,904NCBIRnor6.0
Rnor_5.03114,198,235 - 114,198,454UniSTSRnor5.0
RGSC_v3.43101,989,612 - 101,989,831UniSTSRGSC3.4
Celera3101,761,392 - 101,761,599UniSTS
Cytogenetic Map3q35UniSTS
WI-18493  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23102,746,300 - 102,746,427 (+)MAPPERmRatBN7.2
Rnor_6.03107,563,568 - 107,563,694NCBIRnor6.0
Rnor_5.03114,128,118 - 114,128,244UniSTSRnor5.0
RGSC_v3.43101,919,337 - 101,919,463UniSTSRGSC3.4
Celera3101,691,381 - 101,691,507UniSTS
Cytogenetic Map3q35UniSTS
BF419355  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23102,880,339 - 102,880,554 (+)MAPPERmRatBN7.2
Rnor_6.03107,697,493 - 107,697,707NCBIRnor6.0
Rnor_5.03114,262,043 - 114,262,257UniSTSRnor5.0
RGSC_v3.43102,054,275 - 102,054,489UniSTSRGSC3.4
Celera3101,824,595 - 101,824,809UniSTS
RH 3.4 Map3787.9UniSTS
Cytogenetic Map3q35UniSTS
BF396365  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23102,932,338 - 102,932,478 (+)MAPPERmRatBN7.2
Rnor_6.03107,749,428 - 107,749,567NCBIRnor6.0
Rnor_6.03107,382,487 - 107,382,626NCBIRnor6.0
Rnor_5.03114,313,763 - 114,313,902UniSTSRnor5.0
Rnor_5.03113,948,629 - 113,948,768UniSTSRnor5.0
RGSC_v3.43102,106,052 - 102,106,191UniSTSRGSC3.4
Celera3101,876,568 - 101,876,707UniSTS
RH 3.4 Map3790.6UniSTS
Cytogenetic Map3q35UniSTS
RH132496  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23102,944,807 - 102,945,011 (+)MAPPERmRatBN7.2
Rnor_6.03107,761,886 - 107,762,089NCBIRnor6.0
Rnor_5.03114,326,201 - 114,326,404UniSTSRnor5.0
RGSC_v3.43102,118,851 - 102,119,054UniSTSRGSC3.4
Celera3101,889,063 - 101,889,266UniSTS
RH 3.4 Map3791.1UniSTS
Cytogenetic Map3q35UniSTS
BE097664  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23102,755,593 - 102,755,745 (+)MAPPERmRatBN7.2
Rnor_6.03107,572,861 - 107,573,012NCBIRnor6.0
Rnor_5.03114,137,411 - 114,137,562UniSTSRnor5.0
RGSC_v3.43101,928,630 - 101,928,781UniSTSRGSC3.4
Celera3101,700,650 - 101,700,801UniSTS
RH 3.4 Map3796.7UniSTS
Cytogenetic Map3q35UniSTS
BF395876  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23102,754,777 - 102,755,001 (+)MAPPERmRatBN7.2
Rnor_6.03107,572,045 - 107,572,268NCBIRnor6.0
Rnor_5.03114,136,595 - 114,136,818UniSTSRnor5.0
RGSC_v3.43101,927,814 - 101,928,037UniSTSRGSC3.4
Celera3101,699,834 - 101,700,057UniSTS
RH 3.4 Map3796.0UniSTS
Cytogenetic Map3q35UniSTS
RH138147  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23102,900,624 - 102,900,812 (+)MAPPERmRatBN7.2
Rnor_6.03107,718,033 - 107,718,220NCBIRnor6.0
Rnor_5.03114,282,368 - 114,282,555UniSTSRnor5.0
RGSC_v3.43102,074,336 - 102,074,523UniSTSRGSC3.4
Celera3101,844,868 - 101,845,055UniSTS
RH 3.4 Map3788.3UniSTS
Cytogenetic Map3q35UniSTS
AU048515  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23102,937,955 - 102,938,118 (+)MAPPERmRatBN7.2
Rnor_6.03107,755,041 - 107,755,203NCBIRnor6.0
Rnor_5.03114,319,376 - 114,319,538UniSTSRnor5.0
RGSC_v3.43102,111,665 - 102,111,827UniSTSRGSC3.4
Cytogenetic Map3q35UniSTS
UniSTS:234491  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23102,743,571 - 102,743,724 (+)MAPPERmRatBN7.2
Rnor_6.03107,560,839 - 107,560,991NCBIRnor6.0
Rnor_5.03114,125,389 - 114,125,541UniSTSRnor5.0
RGSC_v3.43101,916,608 - 101,916,760UniSTSRGSC3.4
Celera3101,688,652 - 101,688,804UniSTS
Cytogenetic Map3q35UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
23 12 83 195 91 90 59 38 59 6 368 163 21 170 115 124 31 30 30

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001415696 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006234743 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006234744 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006234745 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006234746 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006234747 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006234748 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006234749 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006234750 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006234751 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006234752 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006234753 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006234755 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039104936 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039104937 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide CH473949 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000003 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000051638   ⟹   ENSRNOP00000047254
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3123,197,254 - 123,397,751 (-)Ensembl
mRatBN7.2 Ensembl3102,742,930 - 102,949,696 (-)Ensembl
Rnor_6.0 Ensembl3107,560,197 - 107,760,589 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000077091   ⟹   ENSRNOP00000068546
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3123,197,066 - 123,397,043 (-)Ensembl
mRatBN7.2 Ensembl3102,742,900 - 102,942,351 (-)Ensembl
Rnor_6.0 Ensembl3107,559,997 - 107,760,550 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000098248   ⟹   ENSRNOP00000093627
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3123,197,066 - 123,397,751 (-)Ensembl
mRatBN7.2 Ensembl3102,742,900 - 102,949,696 (-)Ensembl
RefSeq Acc Id: NM_001415696   ⟹   NP_001402625
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83123,197,066 - 123,397,751 (-)NCBI
mRatBN7.23102,742,904 - 102,943,588 (-)NCBI
RefSeq Acc Id: XM_006234746   ⟹   XP_006234808
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83123,197,067 - 123,399,002 (-)NCBI
mRatBN7.23102,742,905 - 102,944,833 (-)NCBI
Rnor_6.03107,560,172 - 107,762,225 (-)NCBI
Rnor_5.03114,124,722 - 114,327,367 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006234747   ⟹   XP_006234809
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83123,197,067 - 123,397,754 (-)NCBI
mRatBN7.23102,742,905 - 102,943,588 (-)NCBI
Rnor_6.03107,560,172 - 107,760,584 (-)NCBI
Rnor_5.03114,124,722 - 114,327,367 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006234748   ⟹   XP_006234810
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83123,197,067 - 123,396,976 (-)NCBI
mRatBN7.23102,742,905 - 102,942,811 (-)NCBI
Rnor_6.03107,560,172 - 107,760,331 (-)NCBI
Rnor_5.03114,124,722 - 114,327,367 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006234749   ⟹   XP_006234811
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83123,197,067 - 123,397,754 (-)NCBI
mRatBN7.23102,742,905 - 102,943,588 (-)NCBI
Rnor_6.03107,560,172 - 107,760,583 (-)NCBI
Rnor_5.03114,124,722 - 114,327,367 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006234750   ⟹   XP_006234812
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83123,198,488 - 123,399,002 (-)NCBI
mRatBN7.23102,742,905 - 102,944,833 (-)NCBI
Rnor_6.03107,560,172 - 107,762,225 (-)NCBI
Rnor_5.03114,124,722 - 114,327,367 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006234751   ⟹   XP_006234813
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83123,198,488 - 123,399,002 (-)NCBI
mRatBN7.23102,742,905 - 102,944,833 (-)NCBI
Rnor_6.03107,560,172 - 107,762,225 (-)NCBI
Rnor_5.03114,124,722 - 114,327,367 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006234752   ⟹   XP_006234814
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83123,198,488 - 123,397,754 (-)NCBI
mRatBN7.23102,742,905 - 102,943,588 (-)NCBI
Rnor_6.03107,560,172 - 107,760,584 (-)NCBI
Rnor_5.03114,124,722 - 114,327,367 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006234753   ⟹   XP_006234815
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83123,198,488 - 123,396,976 (-)NCBI
mRatBN7.23102,742,905 - 102,942,811 (-)NCBI
Rnor_6.03107,560,172 - 107,760,332 (-)NCBI
Rnor_5.03114,124,722 - 114,327,367 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006234755   ⟹   XP_006234817
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83123,198,488 - 123,396,976 (-)NCBI
mRatBN7.23102,742,905 - 102,942,811 (-)NCBI
Rnor_6.03107,560,172 - 107,760,331 (-)NCBI
Rnor_5.03114,124,722 - 114,327,367 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039104936   ⟹   XP_038960864
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83123,197,067 - 123,399,002 (-)NCBI
mRatBN7.23102,742,905 - 102,944,833 (-)NCBI
RefSeq Acc Id: XM_039104937   ⟹   XP_038960865
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83123,197,067 - 123,396,976 (-)NCBI
mRatBN7.23102,742,905 - 102,942,811 (-)NCBI
RefSeq Acc Id: XP_006234813   ⟸   XM_006234751
- Peptide Label: isoform X8
- UniProtKB: A0A0G2JT27 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006234812   ⟸   XM_006234750
- Peptide Label: isoform X7
- UniProtKB: A0A0G2JT27 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006234808   ⟸   XM_006234746
- Peptide Label: isoform X2
- UniProtKB: A6HP86 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006234811   ⟸   XM_006234749
- Peptide Label: isoform X5
- UniProtKB: A6HP86 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006234809   ⟸   XM_006234747
- Peptide Label: isoform X3
- UniProtKB: A6HP86 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006234814   ⟸   XM_006234752
- Peptide Label: isoform X9
- UniProtKB: A0A0G2JT27 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006234817   ⟸   XM_006234755
- Peptide Label: isoform X11
- UniProtKB: A0A0G2JT27 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006234815   ⟸   XM_006234753
- Peptide Label: isoform X10
- UniProtKB: A0A8I6AHY1 (UniProtKB/TrEMBL),   A0A0G2JT27 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006234810   ⟸   XM_006234748
- Peptide Label: isoform X4
- UniProtKB: A6HP86 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000068546   ⟸   ENSRNOT00000077091
Ensembl Acc Id: ENSRNOP00000047254   ⟸   ENSRNOT00000051638
RefSeq Acc Id: XP_038960864   ⟸   XM_039104936
- Peptide Label: isoform X1
- UniProtKB: A6HP86 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038960865   ⟸   XM_039104937
- Peptide Label: isoform X6
- UniProtKB: D4A2T5 (UniProtKB/TrEMBL),   A6HP86 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000093627   ⟸   ENSRNOT00000098248
RefSeq Acc Id: NP_001402625   ⟸   NM_001415696
- UniProtKB: A0A0G2JT27 (UniProtKB/TrEMBL)
Protein Domains
Homeobox

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A2T5-F1-model_v2 AlphaFold D4A2T5 1-470 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1305198 AgrOrtholog
BioCyc Gene G2FUF-48306 BioCyc
Ensembl Genes ENSRNOG00000004730 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000051638 ENTREZGENE
  ENSRNOT00000051638.5 UniProtKB/TrEMBL
  ENSRNOT00000077091 ENTREZGENE
  ENSRNOT00000077091.2 UniProtKB/TrEMBL
  ENSRNOT00000098248 ENTREZGENE
  ENSRNOT00000098248.1 UniProtKB/TrEMBL
Gene3D-CATH Homeodomain-like UniProtKB/TrEMBL
InterPro Homeobox_KN_domain UniProtKB/TrEMBL
  Homeodomain UniProtKB/TrEMBL
  Homeodomain-like UniProtKB/TrEMBL
  PKNOX/Meis_N UniProtKB/TrEMBL
  TALE_homeobox UniProtKB/TrEMBL
NCBI Gene 311311 ENTREZGENE
PANTHER HOMEOBOX PROTEIN TRANSCRIPTION FACTORS UniProtKB/TrEMBL
Pfam Homeobox_KN UniProtKB/TrEMBL
  Meis_PKNOX_N UniProtKB/TrEMBL
PhenoGen Meis2 PhenoGen
PROSITE HOMEOBOX_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000004730 RatGTEx
SMART HOX UniProtKB/TrEMBL
Superfamily-SCOP Homeodomain_like UniProtKB/TrEMBL
UniProt A0A0G2JT27 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AHY1 ENTREZGENE, UniProtKB/TrEMBL
  A6HP86 ENTREZGENE, UniProtKB/TrEMBL
  D4A2T5 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2009-03-18 Meis2  Meis homeobox 2  Meis2  Meis1, myeloid ecotropic viral integration site 1 homolog 2   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Meis2  Meis1, myeloid ecotropic viral integration site 1 homolog 2   Meis2_predicted  Meis1, myeloid ecotropic viral integration site 1 homolog 2 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Meis2_predicted  Meis1, myeloid ecotropic viral integration site 1 homolog 2 (predicted)      Symbol and Name status set to approved 70820 APPROVED