Mcm3 (minichromosome maintenance complex component 3)

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Gene: Mcm3 (minichromosome maintenance complex component 3) Rattus norvegicus

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Symbol:

Mcm3

Name:

minichromosome maintenance complex component 3

RGD ID:

1305168

Description:

Predicted to enable single-stranded DNA binding activity. Predicted to contribute to single-stranded DNA helicase activity. Predicted to be involved in DNA metabolic process. Predicted to be located in centrosome; nucleoplasm; and perinuclear region of cytoplasm. Predicted to be part of CMG complex and MCM complex. Predicted to be active in nucleus. Orthologous to human MCM3 (minichromosome maintenance complex component 3); PARTICIPATES IN cell cycle pathway, mitotic; DNA replication pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 17beta-estradiol 3-benzoate.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

DNA replication licensing factor MCM3; LOC316273; minichromosome maintenance deficient 3; minichromosome maintenance deficient 3 (S. cerevisiae)

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	9	30,715,602 - 30,733,746 (-)	NCBI		GRCr8
mRatBN7.2	9	23,219,169 - 23,237,314 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	9	23,219,169 - 23,237,314 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	9	31,708,279 - 31,726,367 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	9	36,828,996 - 36,847,084 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	9	35,144,261 - 35,162,350 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	9	26,914,057 - 26,932,201 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	9	26,914,057 - 26,932,201 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	9	25,770,288 - 25,788,432 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	9	19,536,922 - 19,554,871 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	9	19,534,642 - 19,552,122 (-)	NCBI
Celera	9	20,794,785 - 20,812,805 (-)	NCBI		Celera
Cytogenetic Map	9	q13	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Meier-Gorlin syndrome (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,1-dichloroethene (ISO)

1,2-dimethylhydrazine (ISO)

1,4-dioxane (ISO)

1-chloro-2,4-dinitrobenzene (ISO)

1-naphthyl isothiocyanate (EXP)

14-Deoxy-11,12-didehydroandrographolide (ISO)

17beta-estradiol (EXP,ISO)

17beta-estradiol 3-benzoate (EXP)

2,2',4,4',5,5'-hexachlorobiphenyl (ISO)

2,2',5,5'-tetrachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-diaminotoluene (ISO)

2,6-di-tert-butyl-4-methylphenol (ISO)

3,3',5,5'-tetrabromobisphenol A (ISO)

3-methylcholanthrene (ISO)

4-(ethoxymethylene)-2-phenyloxazol-5-one (ISO)

4-hydroxyphenyl retinamide (ISO)

4-nitrophenol (ISO)

5-fluorouracil (ISO)

6-propyl-2-thiouracil (EXP)

7,12-dimethyltetraphene (ISO)

acetamide (EXP)

acrylamide (ISO)

aflatoxin B1 (EXP,ISO)

all-trans-retinoic acid (ISO)

alpha-amanitin (ISO)

AM-251 (ISO)

aminoglutethimide (ISO)

amphetamine (EXP)

anthracene-1,8,9-triol (ISO)

aristolochic acid A (ISO)

arsenous acid (ISO)

auraptene (ISO)

azathioprine (ISO)

belinostat (ISO)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

benzo[b]fluoranthene (ISO)

bis(2-chloroethyl) sulfide (ISO)

bisphenol A (EXP,ISO)

bromobenzene (EXP)

cadmium dichloride (ISO)

caffeine (ISO)

calcitriol (ISO)

cannabidiol (ISO)

carbamazepine (ISO)

carbon nanotube (ISO)

cefaloridine (EXP)

CGP 52608 (ISO)

chlorpromazine (ISO)

cholic acid (ISO)

chromium(6+) (ISO)

cisplatin (EXP,ISO)

cobalt dichloride (ISO)

copper atom (EXP,ISO)

copper(0) (EXP,ISO)

copper(II) sulfate (ISO)

corticosterone (EXP)

coumarin (EXP)

coumestrol (ISO)

Cuprizon (EXP)

cyclosporin A (ISO)

DDE (ISO)

decabromodiphenyl ether (ISO)

deguelin (ISO)

dextran sulfate (ISO)

diarsenic trioxide (ISO)

dibenz[a,h]anthracene (ISO)

Dibutyl phosphate (ISO)

dibutyl phthalate (ISO)

diminazene diaceturate (ISO)

dioxygen (ISO)

Enterolactone (ISO)

enzyme inhibitor (ISO)

FR900359 (ISO)

furan (EXP)

glycine betaine (EXP)

glyphosate (ISO)

GW 3965 (ISO)

hydrogen peroxide (ISO)

iron dichloride (ISO)

iron trichloride (ISO)

iron(III) nitrilotriacetate (EXP)

ivermectin (ISO)

ketamine (EXP)

lead(0) (ISO)

lidocaine (EXP)

lipopolysaccharide (ISO)

menadione (ISO)

methylseleninic acid (ISO)

Mezerein (ISO)

miconazole (ISO)

N-(6-acetamidohexyl)acetamide (ISO)

N-nitrosodiethylamine (ISO)

nickel atom (ISO)

Nonylphenol (ISO)

ochratoxin A (EXP)

oxaliplatin (EXP)

ozone (ISO)

palytoxin (ISO)

paracetamol (EXP,ISO)

parathion (ISO)

PCB138 (ISO)

pentachlorophenol (ISO)

perfluorohexanesulfonic acid (ISO)

perfluorooctanoic acid (ISO)

phenobarbital (ISO)

phorbol 13-acetate 12-myristate (ISO)

picoxystrobin (ISO)

pirinixic acid (ISO)

piroxicam (ISO)

pregnenolone 16alpha-carbonitrile (ISO)

progesterone (ISO)

quercetin (ISO)

resveratrol (ISO)

rotenone (ISO)

saccharin (ISO)

SB 431542 (ISO)

senecionine (EXP)

silver atom (ISO)

silver(0) (ISO)

silver(1+) nitrate (ISO)

sodium arsenite (ISO)

sodium dichromate (EXP)

sodium fluoride (ISO)

sodium nitrite (ISO)

styrene oxide (ISO)

sulfadimethoxine (ISO)

sunitinib (ISO)

tert-butyl hydroperoxide (ISO)

testosterone (EXP,ISO)

tetrachloromethane (ISO)

thapsigargin (ISO)

thioacetamide (EXP)

thiram (ISO)

titanium dioxide (ISO)

toluene 2,4-diisocyanate (ISO)

topotecan (EXP)

Tributyltin oxide (ISO)

trichostatin A (ISO)

trimellitic anhydride (ISO)

triphenyl phosphate (ISO)

troglitazone (ISO)

tunicamycin (ISO)

urethane (ISO)

valproic acid (ISO)

zinc dichloride (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

chromatin looping (IEA)

chromatin remodeling (IEA)

DNA strand elongation involved in DNA replication (IBA)

DNA unwinding involved in DNA replication (ISO)

double-strand break repair via break-induced replication (IBA)

mitotic DNA replication initiation (IBA)

Cellular Component

centrosome (IEA,ISO)

CMG complex (ISO)

cytoplasm (ISO)

MCM complex (IBA,ISO)

nucleolus (ISO)

nucleoplasm (ISO)

nucleus (IBA,ISO)

perinuclear region of cytoplasm (ISO)

Molecular Function

ATP binding (IEA)

ATP hydrolysis activity (IEA)

ATP-dependent H2AZ histone chaperone activity (IEA)

ATP-dependent H3-H4 histone complex chaperone activity (IEA)

chromatin extrusion motor activity (IEA)

cohesin loader activity (IEA)

DNA clamp loader activity (IEA)

double-stranded DNA helicase activity (IEA)

forked DNA-dependent helicase activity (IEA)

four-way junction helicase activity (IEA)

protein binding (ISO)

single-stranded 3'-5' DNA helicase activity (IEA)

single-stranded DNA binding (IBA)

single-stranded DNA helicase activity (IBA)

Molecular Pathway Annotations Click to see Annotation Detail View

cell cycle pathway, mitotic (IEA)

DNA replication pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
4.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
5.	GOA pipeline	RGD automated data pipeline
6.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:17296731	PMID:18590716	PMID:19135898	PMID:19946888	PMID:20531406	PMID:21383955	PMID:22082260	PMID:25002582	PMID:30361391	PMID:31505169

Genomics

Comparative Map Data

Mcm3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	9	30,715,602 - 30,733,746 (-)	NCBI		GRCr8
mRatBN7.2	9	23,219,169 - 23,237,314 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	9	23,219,169 - 23,237,314 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	9	31,708,279 - 31,726,367 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	9	36,828,996 - 36,847,084 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	9	35,144,261 - 35,162,350 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	9	26,914,057 - 26,932,201 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	9	26,914,057 - 26,932,201 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	9	25,770,288 - 25,788,432 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	9	19,536,922 - 19,554,871 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	9	19,534,642 - 19,552,122 (-)	NCBI
Celera	9	20,794,785 - 20,812,805 (-)	NCBI		Celera
Cytogenetic Map	9	q13	NCBI

MCM3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	6	52,264,015 - 52,284,742 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	6	52,264,014 - 52,284,881 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	6	52,128,813 - 52,149,540 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	6	52,236,771 - 52,257,541 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	6	52,236,770 - 52,257,541	NCBI
Celera	6	53,789,937 - 53,810,711 (-)	NCBI		Celera
Cytogenetic Map	6	p12.2	NCBI
HuRef	6	51,960,041 - 51,980,910 (-)	NCBI		HuRef
CHM1_1	6	52,131,052 - 52,151,919 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	6	52,102,764 - 52,123,487 (-)	NCBI		T2T-CHM13v2.0

Mcm3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	1	20,873,188 - 20,890,536 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	1	20,873,192 - 20,890,536 (-)	Ensembl		GRCm39 Ensembl
GRCm38	1	20,802,966 - 20,820,312 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	1	20,802,968 - 20,820,312 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	1	20,793,095 - 20,810,294 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	1	20,788,165 - 20,805,364 (-)	NCBI		MGSCv36	mm8
Celera	1	20,676,980 - 20,695,949 (-)	NCBI		Celera
Cytogenetic Map	1	A4	NCBI
cM Map	1	6.5	NCBI

Mcm3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955411	5,814,041 - 5,832,796 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955411	5,800,800 - 5,832,713 (+)	NCBI	ChiLan1.0	ChiLan1.0

MCM3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	5	66,732,230 - 66,754,058 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	6	62,609,065 - 62,629,834 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	6	51,816,615 - 51,837,404 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	6	53,084,657 - 53,105,403 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	6	53,085,231 - 53,105,344 (-)	Ensembl	panpan1.1		panPan2

MCM3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	12	19,924,017 - 19,945,576 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	12	19,920,210 - 19,945,605 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	12	19,821,166 - 19,842,529 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	12	20,422,999 - 20,444,648 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	12	20,422,997 - 20,444,648 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	12	19,928,809 - 19,950,166 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	12	20,031,993 - 20,053,341 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	12	20,170,450 - 20,191,818 (-)	NCBI		UU_Cfam_GSD_1.0

Mcm3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404946	55,412,234 - 55,429,506 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936476	8,530,688 - 8,547,978 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936476	8,530,614 - 8,547,971 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

MCM3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	7	46,084,662 - 46,104,375 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	7	46,084,648 - 46,104,425 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	7	52,534,805 - 52,554,554 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

MCM3
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	17	20,222,440 - 20,243,807 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	17	20,222,590 - 20,243,809 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666044	52,162,228 - 52,183,499 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Mcm3
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624855	3,806,553 - 3,827,873 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624855	3,806,273 - 3,825,143 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Mcm3
125 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	49
Count of miRNA genes:	47
Interacting mature miRNAs:	47
Transcripts:	ENSRNOT00000017081
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
631211	Bw4	Body weight QTL4	5.31		retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	9	5109826	50109826	Rat
2303559	Gluco54	Glucose level QTL 54	2		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	9	1254084	46254084	Rat
7411609	Foco16	Food consumption QTL 16	25.6	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	9	8952560	53952560	Rat
631680	Cm11	Cardiac mass QTL 11	3.1	0.00089	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	9	20430519	65430519	Rat
70186	Niddm26	Non-insulin dependent diabetes mellitus QTL 26	3.87		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	9	22071169	86369743	Rat
9589055	Scfw5	Subcutaneous fat weight QTL 5	5.55	0.001	subcutaneous adipose mass (VT:1000472)	abdominal subcutaneous fat pad weight (CMO:0002069)	9	1	37999212	Rat
1641911	Alcrsp13	Alcohol response QTL 13			response to alcohol trait (VT:0010489)	brain neurotensin receptor 1 density (CMO:0002068)	9	1	43718459	Rat
1354650	Despr5	Despair related QTL 5	4.01	0.0017	locomotor behavior trait (VT:0001392)	amount of time spent in voluntary immobility (CMO:0001043)	9	1254084	46254084	Rat
1300124	Cm4	Cardiac mass QTL 4	3.55		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	9	1	40594091	Rat
61425	Cia15	Collagen induced arthritis QTL 15	4.6		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	9	5109826	42921101	Rat
631643	Bp120	Blood pressure QTL 120	3	0.004	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	9	22071200	67071200	Rat
70226	Eae4	Experimental allergic encephalomyelitis QTL 4			nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)	9	1	25661317	Rat
9589158	Gluco65	Glucose level QTL 65	6.82	0.001	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	9	1	37999212	Rat
10054125	Srcrt7	Stress Responsive Cort QTL 7	3.33	0.0011	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	9	1	87073594	Rat
724543	Cm20	Cardiac mass QTL 20	3.9		heart mass (VT:0007028)	calculated heart weight (CMO:0000073)	9	16961398	40594091	Rat
1600365	Mcs20	Mammary carcinoma susceptibility QTL 20	3		mammary gland integrity trait (VT:0010552)	mammary tumor growth rate (CMO:0000344)	9	13533770	42791750	Rat
11353947	Bp392	Blood pressure QTL 392			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	9	7283252	52283252	Rat
7411592	Foco8	Food consumption QTL 8	7.4	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	9	1	37999212	Rat
1331757	Cdexp1	CD45RC expression in CD8 T cells QTL 1	4.3		CD8-positive T cell quantity (VT:0008077)	blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)	9	1024537	67509080	Rat
1298088	Edpm11	Estrogen-dependent pituitary mass QTL 11	2.5		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	9	1	43718459	Rat
9589133	Insul26	Insulin level QTL 26	17.96	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	9	8952560	53952560	Rat
1598823	Memor16	Memory QTL 16	1.9		exploratory behavior trait (VT:0010471)	difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)	9	22133322	49968732	Rat

Markers in Region

RH141374

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	9	23,219,253 - 23,219,433 (+)	MAPPER	mRatBN7.2
Rnor_6.0	9	26,914,142 - 26,914,321	NCBI	Rnor6.0
Rnor_5.0	9	25,770,373 - 25,770,552	UniSTS	Rnor5.0
RGSC_v3.4	9	19,537,007 - 19,537,186	UniSTS	RGSC3.4
Celera	9	20,794,870 - 20,795,049	UniSTS
RH 3.4 Map	9	229.1	UniSTS
Cytogenetic Map	9	q13	UniSTS

MARC_3939-3940:996679197:3

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	9	23,234,555 - 23,235,166 (+)	MAPPER	mRatBN7.2
Rnor_6.0	9	26,929,443 - 26,930,053	NCBI	Rnor6.0
Rnor_5.0	9	25,785,674 - 25,786,284	UniSTS	Rnor5.0
RGSC_v3.4	9	19,552,130 - 19,552,740	UniSTS	RGSC3.4
Celera	9	20,810,047 - 20,810,657	UniSTS
Cytogenetic Map	9	q13	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001191805	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAXUCZ010000009	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000017081 ⟹ ENSRNOP00000017081

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	9	23,219,169 - 23,237,314 (-)	Ensembl
Rnor_6.0 Ensembl	9	26,914,057 - 26,932,201 (-)	Ensembl

RefSeq Acc Id:

NM_001191805 ⟹ NP_001178734

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	9	30,715,602 - 30,733,746 (-)	NCBI
mRatBN7.2	9	23,219,169 - 23,237,314 (-)	NCBI
Rnor_6.0	9	26,914,057 - 26,932,201 (-)	NCBI
Rnor_5.0	9	25,770,288 - 25,788,432 (-)	NCBI
Celera	9	20,794,785 - 20,812,805 (-)	NCBI

Sequence:

show sequence

AAACTTGGGAAGTTTTCGCGCCAGGGAGGAGTCACACACGTTTTTATTTTTTGCGGGACTCTTT
GGTGGCCGGCGATTTCGGGGCAGCGGCATGGCGGGTACCGTAGTGCTGGACGACGTGGAGCTGC
GCGAAGCGCAGAGAGACTACTTGGACTTCCTGGACGACGAGGAAGACCAAGGAATTTACCAGAA
TAAAGTTCGGGAGCTGATCAGTGACAACCAGTATCGGCTGATTGTCAATGTGAATGACCTGCGC
AGGAAAAATGAAAAGAGGGCTAACCGCCTCCTGAACAATGCTTTCGAGGAGCTGGTTGCCTTCC
AGCGGGCCTTGAAGGATTTCGTGGCCTCCATTGACGCTACCTATGCCAAGCAGTACGAGGAGTT
CTACATAGGCCTAGAGGGCAGCTTCGGCTCAAAGCACGTCTCTCCCCGGACTCTCACTTCCTGC
TTCCTTAGCTGTGTGGTCTGCGTGGAAGGCATCGTTACCAAATGCTCTCTGGTTCGCCCCAAGG
TCGTTCGCAGCGTTCACTACTGTCCTGCTACTAAGAAGACCATAGAGCGGCGCTACTCTGACCT
CACCACCCTGGTGGCTTTCCCATCCAGTTCTGTTTATCCCACAAAGGATGAGGAGAACAACCCC
CTGGAGACAGAGTATGGCTTGTCTGTCTACAAGGACCACCAGACCATCACCATCCAGGAGATGC
CGGAGAAGGCCCCAGCCGGTCAGCTTCCTCGATCTGTGGATGTCATTCTAGATGATGATCTGGT
AGATAAAGTGAAACCTGGTGACAGAATCCAGGTGGTTGGGACCTACCGCTGCCTTCCAGGAAAG
AAGGGTGGCTACACCTCGGGGACCTTCAGGACCGTCCTGATCGCCTGCAACGTGAAGCAGATGA
GCAAGGACATTCAGCCTGCGTTCTCTGCAGACGATATAGCAAAGATCAAGAAGTTCAGCAAAAC
CCGTTCCAAGGATGTCTTTGAGCAGTTGGCCCGATCGTTAGCCCCTAGCATCCATGGGCATGAC
TATGTCAAGAAAGCAATCCTCTGCTTGCTCCTGGGAGGGGTGGAACGGGAACTTGAAAACGGCA
GCCACATCCGTGGAGATATCAATATTCTCCTAATAGGTGACCCATCAGTCGCCAAGTCCCAGCT
TCTGCGGTATGTGCTTTGCACCGCACCCAGGGCCATTCCCACCACGGGTCGGGGCTCGTCTGGA
GTGGGTCTCACAGCAGCCGTCACCACAGACCAGGAAACCGGGGAGCGCCGCCTGGAAGCTGGTG
CCATGGTCCTGGCTGACCGAGGAGTGGTTTGCATCGATGAGTTCGACAAGATGTCGGACATGGA
CCGCACAGCCATCCATGAGGTGATGGAGCAGGGTAGAGTGACGATCGCGAAGGCTGGCATCCAT
GCCCGGCTCAATGCCCGTTGCAGTGTTTTGGCAGCTGCCAATCCAGTCTATGGCAGGTATGACC
AGTATAAGACACCTATGGAGAACATTGGGCTGCAGGACTCACTGCTGTCTCGGTTTGACCTGCT
CTTCATCATGCTGGATCAGATGGATCCTGAACAGGACCGGGAGATCTCAGACCACGTCCTTAGG
ATGCACCAATACAGGGCCCCGGGGGAGCAGGACGGTGACGCTTTGCCGTTGGGTAGTTCAGTGG
ATATCCTGGCCACAGACGATCCCGACTTTACCCAGGATGACCAGCAAGATACCCGGATTTATGA
GAAGCATGACAACCTTCTACATGGGTCCAAGAAGAAAAGGGAGAAGATGGTGAGCGCAGCTTTC
ATGAAGAAGTACATCCACGTGGCCAAAATTATTAAACCGACCCTGACGCAGGAGTCCGCAGCCT
ACATTGCAGAAGAATACTCTCGCCTGCGCAGCCAGGACAGCATGAGCTCAGACACTGCCCGGAC
ATCTCCGGTTACAGCACGGACACTGGAAACTCTGATTCGACTGGCCACGGCCCATGCGAAGGCC
CGTATGAGCAAGACTGTGGACCTGCAAGATGCGGAGGAAGCTGTGGAACTGGTGCAGTATGCTT
ATTTCAAGAAGGTTCTGGAAAAGGAGAAGAAACGTAAGAAGCCAAGTGAGGATGAATCAGACCT
GGAGGATGAAGAGGAGAAGAGCCAGGAGGAGGACACTGAGCAGACTCGGAAGAGGAGGAAGACT
CAAGCCAAGGATGGGGAGTCCTATGACCCTTATGACTTCAGTGAAGCAGAGAGGGAAATGCCTC
AAGTGCACACCCCGAAGACCGACGACTCTCAAGAGAAGACAGATGAGTCTCAGGAGACCCAGGA
GTCCCAGAAAGTGGAGCTGAGTGAGTCCAGGCTGAAGGCTTTTAAGGCGGCTCTCTTAGAAGTG
TTCCAGGAGGCTCACGCGCAGTCTGTGGGCATGATCCACCTCACGGAATCCATCAATCGGAATA
AAGAAGAACCCTTCTCCTCAGAGGAAATCCAGGCCTCACTGAGCCGGATGCAGGACGATAACCA
GGTCATGGTGTCTGAGGGCATCGTCTTCCTTATCTGAGGCTGCCCTGACCCCAGCCTTTGTCTC
CATTTTCCAGTAACTGTCAGTGATGGAAGCTGATGGCGAGACTATCAGGCCTTTGGAAGCTTTG
AGAATGACTTCTGTGGGGCAAGAGCTGGAGGAGCGCTGGGTCACACACCTCCCAGTGCTAAGTT
GGGAAGTCTCCATGACTTGAGCCGTGTTTCTGGGCACAGCTGTTCTCTGCATTTGTTACTTGTG
TTTTTACCCCCAGCCCCACCCCCAAGCACTTTAGTCCAGGAAACCTTGGGGTCTGCTGTGCCAA
GGTGGCTCAGGCAGATCACAGAGTTGGATTGGAGAGAGCTTTCTTTGCAATTAGGCTAGTATGT
ATTGACCTAAATATCCAAGACTAAGTAAATATAACTATTTTGTACATGTGGA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001178734	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000017081.7

RefSeq Acc Id:

NP_001178734 ⟸ NM_001191805

- UniProtKB:

D3ZFP4 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MAGTVVLDDVELREAQRDYLDFLDDEEDQGIYQNKVRELISDNQYRLIVNVNDLRRKNEKRANR
LLNNAFEELVAFQRALKDFVASIDATYAKQYEEFYIGLEGSFGSKHVSPRTLTSCFLSCVVCVE
GIVTKCSLVRPKVVRSVHYCPATKKTIERRYSDLTTLVAFPSSSVYPTKDEENNPLETEYGLSV
YKDHQTITIQEMPEKAPAGQLPRSVDVILDDDLVDKVKPGDRIQVVGTYRCLPGKKGGYTSGTF
RTVLIACNVKQMSKDIQPAFSADDIAKIKKFSKTRSKDVFEQLARSLAPSIHGHDYVKKAILCL
LLGGVERELENGSHIRGDINILLIGDPSVAKSQLLRYVLCTAPRAIPTTGRGSSGVGLTAAVTT
DQETGERRLEAGAMVLADRGVVCIDEFDKMSDMDRTAIHEVMEQGRVTIAKAGIHARLNARCSV
LAAANPVYGRYDQYKTPMENIGLQDSLLSRFDLLFIMLDQMDPEQDREISDHVLRMHQYRAPGE
QDGDALPLGSSVDILATDDPDFTQDDQQDTRIYEKHDNLLHGSKKKREKMVSAAFMKKYIHVAK
IIKPTLTQESAAYIAEEYSRLRSQDSMSSDTARTSPVTARTLETLIRLATAHAKARMSKTVDLQ
DAEEAVELVQYAYFKKVLEKEKKRKKPSEDESDLEDEEEKSQEEDTEQTRKRRKTQAKDGESYD
PYDFSEAEREMPQVHTPKTDDSQEKTDESQETQESQKVELSESRLKAFKAALLEVFQEAHAQSV
GMIHLTESINRNKEEPFSSEEIQASLSRMQDDNQVMVSEGIVFLI

hide sequence

Ensembl Acc Id:

ENSRNOP00000017081 ⟸ ENSRNOT00000017081

Protein Domains

MCM

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D3ZFP4-F1-model_v2	AlphaFold	D3ZFP4	1-813	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13696572

Promoter ID:

EPDNEW_R7097

Type:

initiation region

Name:

Mcm3_1

Description:

minichromosome maintenance complex component 3

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	9	26,932,148 - 26,932,208	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1305168	AgrOrtholog
BioCyc Gene	G2FUF-28030	BioCyc
Ensembl Genes	ENSRNOG00000012543	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000017081.8	UniProtKB/TrEMBL
Gene3D-CATH	2.20.28.10	UniProtKB/TrEMBL
	2.40.50.140	UniProtKB/TrEMBL
	3.40.50.300	UniProtKB/TrEMBL
	mini-chromosome maintenance (MCM) complex, chain A, domain 1	UniProtKB/TrEMBL
InterPro	AAA+_ATPase	UniProtKB/TrEMBL
	DNA-dep_ATPase_MCM	UniProtKB/TrEMBL
	DNA-dep_ATPase_MCM_CS	UniProtKB/TrEMBL
	MCM	UniProtKB/TrEMBL
	MCM_3	UniProtKB/TrEMBL
	MCM_lid	UniProtKB/TrEMBL
	MCM_N	UniProtKB/TrEMBL
	MCM_OB	UniProtKB/TrEMBL
	NA-bd_OB-fold	UniProtKB/TrEMBL
	P-loop_NTPase	UniProtKB/TrEMBL
KEGG Report	rno:316273	UniProtKB/TrEMBL
NCBI Gene	316273	ENTREZGENE
PANTHER	DNA REPLICATION LICENSING FACTOR MCM3	UniProtKB/TrEMBL
	PTHR11630	UniProtKB/TrEMBL
Pfam	MCM	UniProtKB/TrEMBL
	MCM_lid	UniProtKB/TrEMBL
	MCM_N	UniProtKB/TrEMBL
	MCM_OB	UniProtKB/TrEMBL
PhenoGen	Mcm3	PhenoGen
PRINTS	MCMFAMILY	UniProtKB/TrEMBL
	MCMPROTEIN3	UniProtKB/TrEMBL
PROSITE	MCM_1	UniProtKB/TrEMBL
	MCM_2	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000012543	RatGTEx
SMART	AAA	UniProtKB/TrEMBL
	MCM	UniProtKB/TrEMBL
Superfamily-SCOP	Nucleic_acid_OB	UniProtKB/TrEMBL
	SSF52540	UniProtKB/TrEMBL
UniProt	D3ZFP4	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-10-24	Mcm3	minichromosome maintenance complex component 3	Mcm3	minichromosome maintenance deficient 3 (S. cerevisiae)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	Mcm3	minichromosome maintenance deficient 3 (S. cerevisiae)	Mcm3_predicted	minichromosome maintenance deficient 3 (S. cerevisiae) (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-12	Mcm3_predicted	minichromosome maintenance deficient 3 (S. cerevisiae) (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

Imported Annotations - KEGG (archival)