Nsmce2 (NSE2/MMS21 homolog, SMC5-SMC6 complex SUMO ligase) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Nsmce2 (NSE2/MMS21 homolog, SMC5-SMC6 complex SUMO ligase) Rattus norvegicus
Analyze
Symbol: Nsmce2
Name: NSE2/MMS21 homolog, SMC5-SMC6 complex SUMO ligase
RGD ID: 1305156
Description: Predicted to enable SUMO ligase activity. Predicted to be involved in several processes, including DNA recombination; positive regulation of cell cycle process; and protein sumoylation. Predicted to be located in PML body and chromosome, telomeric region. Predicted to be part of Smc5-Smc6 complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in Seckel syndrome 10. Orthologous to human NSMCE2 (NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase); INTERACTS WITH bisphenol A; Cuprizon; finasteride.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: E3 SUMO-protein ligase NSE2; E3 SUMO-protein transferase NSE2; LOC299957; MGC114542; MMS21 homolog; non-SMC element 2 homolog; non-SMC element 2, MMS21 homolog; non-SMC element 2, MMS21 homolog (S. cerevisiae); non-structural maintenance of chromosomes element 2 homolog; RGD1305156; similar to RIKEN cDNA 1110014D18
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8792,825,568 - 93,071,037 (+)NCBIGRCr8
mRatBN7.2790,936,112 - 91,173,435 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl790,936,112 - 91,164,899 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx792,826,087 - 93,044,522 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0795,027,272 - 95,245,732 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0794,854,556 - 95,076,868 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0799,677,295 - 99,900,765 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl799,677,290 - 99,900,764 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07100,263,539 - 100,486,903 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4796,167,635 - 96,393,594 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1796,201,864 - 96,427,823 (+)NCBI
Celera787,697,871 - 87,919,520 (+)NCBICelera
Cytogenetic Map7q33NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
chromosome  (IEA)
chromosome, telomeric region  (IEA,ISO,ISS)
nuclear body  (IEA,ISO)
nucleoplasm  (IEA,ISO)
nucleus  (IBA,IEA)
PML body  (IEA,ISO,ISS)
Smc5-Smc6 complex  (IBA,IEA,ISO,ISS)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:15489334   PMID:16055714   PMID:16810316   PMID:17589526   PMID:18086888   PMID:19502785   PMID:22751501  


Genomics

Comparative Map Data
Nsmce2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8792,825,568 - 93,071,037 (+)NCBIGRCr8
mRatBN7.2790,936,112 - 91,173,435 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl790,936,112 - 91,164,899 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx792,826,087 - 93,044,522 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0795,027,272 - 95,245,732 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0794,854,556 - 95,076,868 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0799,677,295 - 99,900,765 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl799,677,290 - 99,900,764 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07100,263,539 - 100,486,903 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4796,167,635 - 96,393,594 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1796,201,864 - 96,427,823 (+)NCBI
Celera787,697,871 - 87,919,520 (+)NCBICelera
Cytogenetic Map7q33NCBI
NSMCE2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh388125,091,860 - 125,367,120 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl8125,091,679 - 125,367,125 (+)EnsemblGRCh38hg38GRCh38
GRCh378126,104,102 - 126,379,362 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 368126,173,277 - 126,448,544 (+)NCBINCBI36Build 36hg18NCBI36
Celera8122,293,246 - 122,568,218 (+)NCBICelera
Cytogenetic Map8q24.13NCBI
HuRef8121,427,877 - 121,703,222 (+)NCBIHuRef
CHM1_18126,144,698 - 126,419,607 (+)NCBICHM1_1
T2T-CHM13v2.08126,225,519 - 126,500,604 (+)NCBIT2T-CHM13v2.0
Nsmce2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391559,246,047 - 59,473,538 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1559,246,096 - 59,473,533 (+)EnsemblGRCm39 Ensembl
GRCm381559,374,198 - 59,601,689 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1559,374,247 - 59,601,684 (+)EnsemblGRCm38mm10GRCm38
MGSCv371559,205,753 - 59,433,239 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361559,203,928 - 59,431,364 (+)NCBIMGSCv36mm8
Celera1560,905,217 - 61,133,508 (+)NCBICelera
Cytogenetic Map15D1NCBI
cM Map1525.19NCBI
Nsmce2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955461201,764 - 451,776 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955461199,356 - 451,716 (+)NCBIChiLan1.0ChiLan1.0
NSMCE2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v27142,514,870 - 142,789,089 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan18118,026,022 - 118,300,121 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v08121,777,986 - 122,052,094 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.18124,529,245 - 124,803,354 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl8124,529,268 - 124,803,114 (+)Ensemblpanpan1.1panPan2
NSMCE2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11323,078,143 - 23,288,302 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1323,078,173 - 23,288,304 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1323,042,326 - 23,261,292 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01323,419,977 - 23,634,235 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1323,420,016 - 23,634,235 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11323,140,666 - 23,355,264 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01323,249,898 - 23,462,275 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01323,492,960 - 23,706,136 (+)NCBIUU_Cfam_GSD_1.0
Nsmce2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530315,021,038 - 15,241,228 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647022,445,433 - 22,667,559 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647022,447,278 - 22,667,302 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NSMCE2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl414,358,651 - 14,598,077 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1414,359,323 - 14,598,192 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2414,948,825 - 15,035,641 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NSMCE2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.18119,679,090 - 119,949,212 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl8119,691,106 - 119,949,587 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603920,225,964 - 20,495,843 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nsmce2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473529,913,423 - 30,151,922 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473529,915,007 - 30,166,564 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Nsmce2
1842 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:152
Count of miRNA genes:112
Interacting mature miRNAs:121
Transcripts:ENSRNOT00000005376
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)792388565119280177Rat
1331728Bp214Blood pressure QTL 2142.825arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)782111245123048330Rat
2317035Aia16Adjuvant induced arthritis QTL 162.71joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)771103011106126789Rat
1357336Gluco6Glucose level QTL 63.4blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)75170064396700643Rat
1358361Sradr5Stress Responsive Adrenal Weight QTL 55.55adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)731770293110435881Rat
1298525Cm1Cardiac mass QTL 12.7heart mass (VT:0007028)heart wet weight (CMO:0000069)756625161101625161Rat
1357338Stl17Serum triglyceride level QTL 173.23blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)771621154114982716Rat
70159Bp61Blood pressure QTL 610.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)773618702118618702Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)746307490127866166Rat
634322Bw12Body weight QTL 120body mass (VT:0001259)body weight (CMO:0000012)785043242130043242Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)785497398130497398Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)792362341137014596Rat
2317052Aia17Adjuvant induced arthritis QTL 172.13joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)783626689128626689Rat
631529Tls2T-lymphoma susceptibility QTL 200.001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)782111382132099989Rat
1300151Bp181Blood pressure QTL 1813.36arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)755498584105834451Rat
1559283Emca4Estrogen-induced mammary cancer QTL 43.7mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)763889858108889858Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)71011291699900612Rat
738030Anxrr8Anxiety related response QTL 84.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)74847504993475049Rat
1300149Cm6Cardiac mass QTL 64.09heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)71104117804Rat
7411607Foco15Food consumption QTL 150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)777807807122807807Rat
631201Panci1Pancreas inflammation QTL 100.001pancreas integrity trait (VT:0010560)percentage of study population displaying chronic pancreatitis at a point in time (CMO:0001214)773557047118557047Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)71509236116977875Rat
1331768Kidm10Kidney mass QTL 104.62096kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)782111245123048330Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)740540077123682549Rat
1641908Teswt1Testicular weight QTL 13.28testis mass (VT:1000644)both testes wet weight (CMO:0000175)78211124596700643Rat
2316947Rf58Renal function QTL 587.8kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)749682832115766396Rat
10450862Kidm55Kidney mass QTL 554.9kidney mass (VT:0002707)kidney weight (CMO:0000081)772725037117725037Rat
724537Niddm52Non-insulin dependent diabetes mellitus QTL 520.02blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)78211124595485241Rat
1298528Bp169Blood pressure QTL 1690.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)762963207107963207Rat
1331746Kidm9Kidney mass QTL 93.934kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)782111245134948181Rat
1576303Ept7Estrogen-induced pituitary tumorigenesis QTL 73.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)763889858108889858Rat
10450856Livw4Liver weight QTL 43.8liver mass (VT:0003402)liver weight (CMO:0000092)772725037117725037Rat
7411654Foco25Food consumption QTL 259.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)777807807122807807Rat
2316955Stl24Serum triglyceride level QTL 247.1blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)749682832115766396Rat
10402855Bp379Blood pressure QTL 3790.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)778682549123682549Rat
2316952Pur22Proteinuria QTL 225.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)749682832115766396Rat
2303582Gluco53Glucose level QTL 533blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)74860308793603087Rat
631540Bw9Body weight QTL 94.5body mass (VT:0001259)body weight (CMO:0000012)771621154119349044Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)771827901136544683Rat

Markers in Region
D7Rat202  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8793,029,306 - 93,029,532 (+)Marker Load Pipeline
mRatBN7.2791,139,876 - 91,140,102 (+)MAPPERmRatBN7.2
Rnor_6.0799,881,975 - 99,882,200NCBIRnor6.0
Rnor_5.07100,468,113 - 100,468,338UniSTSRnor5.0
RGSC_v3.4796,374,800 - 96,375,025UniSTSRGSC3.4
RGSC_v3.4796,374,799 - 96,375,025RGDRGSC3.4
RGSC_v3.1796,409,029 - 96,409,255RGD
Celera787,900,714 - 87,900,939UniSTS
SHRSP x BN Map752.31RGD
SHRSP x BN Map752.31UniSTS
Cytogenetic Map7q33UniSTS
D7Got73  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2790,995,773 - 90,995,980 (+)MAPPERmRatBN7.2
Rnor_6.0799,736,992 - 99,737,198NCBIRnor6.0
Rnor_5.07100,323,130 - 100,323,336UniSTSRnor5.0
RGSC_v3.4796,228,858 - 96,229,065RGDRGSC3.4
RGSC_v3.4796,228,859 - 96,229,065UniSTSRGSC3.4
RGSC_v3.1796,263,088 - 96,263,295RGD
Celera787,757,197 - 87,757,403UniSTS
RH 2.0 Map7559.1RGD
Cytogenetic Map7q33UniSTS
RH142770  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2791,023,331 - 91,023,598 (+)MAPPERmRatBN7.2
Rnor_6.0799,764,392 - 99,764,658NCBIRnor6.0
Rnor_5.07100,350,530 - 100,350,796UniSTSRnor5.0
RGSC_v3.4796,256,413 - 96,256,679UniSTSRGSC3.4
Celera787,784,726 - 87,784,992UniSTS
Cytogenetic Map7q33UniSTS
RH128753  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2791,158,412 - 91,158,566 (+)MAPPERmRatBN7.2
Rnor_6.0799,900,503 - 99,900,656NCBIRnor6.0
Rnor_5.07100,486,641 - 100,486,794UniSTSRnor5.0
RGSC_v3.4796,393,332 - 96,393,485UniSTSRGSC3.4
Celera787,919,258 - 87,919,411UniSTS
Cytogenetic Map7q33UniSTS
BF404967  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2791,043,803 - 91,044,047 (+)MAPPERmRatBN7.2
Rnor_6.0799,785,157 - 99,785,400NCBIRnor6.0
Rnor_5.07100,371,295 - 100,371,538UniSTSRnor5.0
RGSC_v3.4796,276,885 - 96,277,128UniSTSRGSC3.4
Celera787,805,191 - 87,805,434UniSTS
RH 3.4 Map7652.1UniSTS
Cytogenetic Map7q33UniSTS
BE119183  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2791,077,386 - 91,077,573 (+)MAPPERmRatBN7.2
Rnor_6.0799,819,309 - 99,819,495NCBIRnor6.0
Rnor_5.07100,405,447 - 100,405,633UniSTSRnor5.0
RGSC_v3.4796,311,836 - 96,312,022UniSTSRGSC3.4
Celera787,838,310 - 87,838,496UniSTS
RH 3.4 Map7651.27UniSTS
Cytogenetic Map7q33UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001024876 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006241671 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594758 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594759 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594760 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594761 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039078795 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039078798 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039078799 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063263259 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063263260 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001838681 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005486582 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010052954 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010052955 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010052956 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010052957 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010052958 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide BC097477 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473950 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000007 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000005376   ⟹   ENSRNOP00000005376
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl790,936,127 - 91,158,668 (+)Ensembl
Rnor_6.0 Ensembl799,677,335 - 99,900,764 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000086039   ⟹   ENSRNOP00000069742
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl790,936,112 - 91,164,899 (+)Ensembl
Rnor_6.0 Ensembl799,677,290 - 99,892,370 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000099968   ⟹   ENSRNOP00000085874
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl790,936,127 - 91,158,668 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000102133   ⟹   ENSRNOP00000097544
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl790,936,163 - 91,101,133 (+)Ensembl
RefSeq Acc Id: NM_001024876   ⟹   NP_001020047
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8792,825,634 - 93,048,103 (+)NCBI
mRatBN7.2790,936,198 - 91,158,675 (+)NCBI
Rnor_6.0799,677,335 - 99,900,765 (+)NCBI
Rnor_5.07100,263,539 - 100,486,903 (+)NCBI
RGSC_v3.4796,167,635 - 96,393,594 (+)RGD
Celera787,697,871 - 87,919,520 (+)RGD
Sequence:
RefSeq Acc Id: XM_006241671   ⟹   XP_006241733
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8792,825,573 - 92,990,575 (+)NCBI
mRatBN7.2790,936,133 - 91,101,143 (+)NCBI
Rnor_6.0799,677,295 - 99,843,064 (+)NCBI
Rnor_5.07100,263,539 - 100,486,903 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017594758   ⟹   XP_017450247
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8792,825,573 - 93,048,103 (+)NCBI
mRatBN7.2790,936,133 - 91,158,675 (+)NCBI
Rnor_6.0799,677,295 - 99,900,765 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017594760   ⟹   XP_017450249
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8792,825,573 - 92,990,575 (+)NCBI
mRatBN7.2790,936,133 - 91,101,143 (+)NCBI
Rnor_6.0799,677,295 - 99,843,064 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039078795   ⟹   XP_038934723
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8792,825,568 - 93,048,103 (+)NCBI
mRatBN7.2790,936,134 - 91,158,675 (+)NCBI
RefSeq Acc Id: XM_039078798   ⟹   XP_038934726
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8792,825,573 - 93,048,103 (+)NCBI
mRatBN7.2790,936,112 - 91,158,675 (+)NCBI
RefSeq Acc Id: XM_039078799   ⟹   XP_038934727
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8792,825,573 - 92,924,805 (+)NCBI
mRatBN7.2790,936,133 - 91,040,285 (+)NCBI
RefSeq Acc Id: XM_063263259   ⟹   XP_063119329
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8792,825,573 - 93,048,103 (+)NCBI
RefSeq Acc Id: XM_063263260   ⟹   XP_063119330
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8792,825,573 - 92,990,575 (+)NCBI
RefSeq Acc Id: XR_001838681
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8792,825,573 - 93,047,967 (+)NCBI
mRatBN7.2790,936,133 - 91,158,672 (+)NCBI
Rnor_6.0799,677,295 - 99,900,759 (+)NCBI
Sequence:
RefSeq Acc Id: XR_005486582
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8792,825,573 - 93,047,967 (+)NCBI
mRatBN7.2790,936,133 - 91,158,463 (+)NCBI
RefSeq Acc Id: XR_010052954
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8792,825,573 - 93,071,037 (+)NCBI
RefSeq Acc Id: XR_010052955
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8792,825,573 - 93,071,037 (+)NCBI
RefSeq Acc Id: XR_010052956
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8792,825,573 - 93,047,967 (+)NCBI
RefSeq Acc Id: XR_010052957
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8792,825,573 - 93,038,647 (+)NCBI
RefSeq Acc Id: XR_010052958
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8792,825,573 - 93,038,647 (+)NCBI
RefSeq Acc Id: NP_001020047   ⟸   NM_001024876
- UniProtKB: Q4V8A0 (UniProtKB/Swiss-Prot),   A6HRM3 (UniProtKB/TrEMBL),   A0A0G2JW49 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006241733   ⟸   XM_006241671
- Peptide Label: isoform X8
- UniProtKB: A0A8I6AS08 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017450247   ⟸   XM_017594758
- Peptide Label: isoform X1
- UniProtKB: A0A8I6A069 (UniProtKB/TrEMBL),   A6HRM2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017450249   ⟸   XM_017594760
- Peptide Label: isoform X4
- Sequence:
Ensembl Acc Id: ENSRNOP00000005376   ⟸   ENSRNOT00000005376
Ensembl Acc Id: ENSRNOP00000069742   ⟸   ENSRNOT00000086039
RefSeq Acc Id: XP_038934726   ⟸   XM_039078798
- Peptide Label: isoform X6
- UniProtKB: A6HRM4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038934727   ⟸   XM_039078799
- Peptide Label: isoform X7
RefSeq Acc Id: XP_038934723   ⟸   XM_039078795
- Peptide Label: isoform X3
Ensembl Acc Id: ENSRNOP00000097544   ⟸   ENSRNOT00000102133
Ensembl Acc Id: ENSRNOP00000085874   ⟸   ENSRNOT00000099968
RefSeq Acc Id: XP_063119329   ⟸   XM_063263259
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063119330   ⟸   XM_063263260
- Peptide Label: isoform X5
Protein Domains
SP-RING-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q4V8A0-F1-model_v2 AlphaFold Q4V8A0 1-247 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695367
Promoter ID:EPDNEW_R5883
Type:initiation region
Name:Nsmce2_1
Description:NSE2/MMS21 homolog, SMC5-SMC6 complex SUMO ligase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0799,677,311 - 99,677,371EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1305156 AgrOrtholog
BioCyc Gene G2FUF-33289 BioCyc
Ensembl Genes ENSRNOG00000003964 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000005376 ENTREZGENE
  ENSRNOT00000005376.6 UniProtKB/Swiss-Prot
  ENSRNOT00000086039 ENTREZGENE
  ENSRNOT00000099968 ENTREZGENE
  ENSRNOT00000102133 ENTREZGENE
Gene3D-CATH 3.30.40.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7458086 IMAGE-MGC_LOAD
InterPro Nse2(Mms21) UniProtKB/Swiss-Prot
  Ubox_domain UniProtKB/Swiss-Prot
  Znf_MIZ UniProtKB/Swiss-Prot
  Znf_RING/FYVE/PHD UniProtKB/Swiss-Prot
KEGG Report rno:299957 UniProtKB/Swiss-Prot
MGC_CLONE MGC:114542 IMAGE-MGC_LOAD
NCBI Gene 299957 ENTREZGENE
PANTHER E3 SUMO-PROTEIN LIGASE NSE2 UniProtKB/Swiss-Prot
  PTHR21330 UniProtKB/Swiss-Prot
Pfam zf-Nse UniProtKB/Swiss-Prot
PhenoGen Nsmce2 PhenoGen
PROSITE ZF_SP_RING UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000003964 RatGTEx
SMART Ubox UniProtKB/Swiss-Prot
Superfamily-SCOP RING/U-box UniProtKB/Swiss-Prot
UniProt A0A0G2JW49 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A069 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AS08 ENTREZGENE, UniProtKB/TrEMBL
  A6HRM2 ENTREZGENE, UniProtKB/TrEMBL
  A6HRM3 ENTREZGENE, UniProtKB/TrEMBL
  A6HRM4 ENTREZGENE, UniProtKB/TrEMBL
  NSE2_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-08-13 Nsmce2  NSE2/MMS21 homolog, SMC5-SMC6 complex SUMO ligase  Nsmce2  non-SMC element 2, MMS21 homolog (S. cerevisiae)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-06 Nsmce2  non-SMC element 2, MMS21 homolog (S. cerevisiae)  RGD1305156  similar to RIKEN cDNA 1110014D18  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 RGD1305156  similar to RIKEN cDNA 1110014D18  RGD1305156_predicted  similar to RIKEN cDNA 1110014D18 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-20 RGD1305156_predicted  similar to RIKEN cDNA 1110014D18 (predicted)  LOC299957_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC299957_predicted  similar to RIKEN cDNA 1110014D18 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL