Prorp (protein only RNase P catalytic subunit)

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Gene: Prorp (protein only RNase P catalytic subunit) Rattus norvegicus

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Symbol:

Prorp

Name:

protein only RNase P catalytic subunit

RGD ID:

1305089

Description:

Predicted to enable ribonuclease P activity. Predicted to be involved in mitochondrial tRNA 5'-end processing and tRNA 5'-leader removal. Predicted to be located in mitochondrial nucleoid and nucleoplasm. Predicted to be part of mitochondrial ribonuclease P complex. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 54. Orthologous to human PRORP (protein only RNase P catalytic subunit); INTERACTS WITH 2,2',5,5'-tetrachlorobiphenyl; acrylamide; bisphenol A.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

LOC299050; mitochondrial ribonuclease P catalytic subunit; mitochondrial ribonuclease P protein 3; mitochondrial RNase P protein 3; Mrpp3; RGD1305089; similar to 1110008L16Rik protein

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	PRORP (protein only RNase P catalytic subunit)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Prorp (protein only RNase P catalytic subunit)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Prorp (protein only RNase P catalytic subunit)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	PRORP (protein only RNase P catalytic subunit)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	PRORP (protein only RNase P catalytic subunit)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Prorp (protein only RNase P catalytic subunit)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	PRORP (protein only RNase P catalytic subunit)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	PRORP (protein only RNase P catalytic subunit)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	PRORP (protein only RNase P catalytic subunit)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Prorp (protein only RNase P catalytic subunit)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	si:dkeyp-33b5.4	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	coa-6	Alliance	DIOPT (Ensembl Compara\|PANTHER)
Drosophila melanogaster (fruit fly):	mldr	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	6	78,404,821 - 78,497,562 (+)	NCBI		GRCr8
mRatBN7.2	6	72,669,659 - 72,762,419 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	6	72,670,847 - 72,762,416 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	6	73,093,590 - 73,182,668 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	6	73,399,942 - 73,489,024 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	6	72,828,549 - 72,917,703 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	6	76,079,880 - 76,171,298 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	6	76,079,880 - 76,171,296 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	6	85,614,276 - 85,708,817 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	6	75,539,870 - 75,633,118 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	6	75,543,495 - 75,636,184 (+)	NCBI
Celera	6	71,512,144 - 71,602,932 (+)	NCBI		Celera
Cytogenetic Map	6	q23	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Brain-Lung-Thyroid Syndrome (ISO)

combined oxidative phosphorylation deficiency 54 (ISO)

Developmental Disabilities (ISO)

ectodermal dysplasia and immunodeficiency 2 (ISO)

Leukoencephalopathies (ISO)

Myoectodermal Gonadal Dysgenesis Syndrome (ISO)

Perrault Syndrome 1 (ISO)

spermatogenic failure 36 (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-epigallocatechin 3-gallate (ISO)

17beta-estradiol (ISO)

2,2',5,5'-tetrachlorobiphenyl (EXP)

acrolein (ISO)

acrylamide (EXP)

aflatoxin B1 (ISO)

alpha-pinene (ISO)

auramine O (ISO)

benzo[a]pyrene (ISO)

benzo[e]pyrene (ISO)

bisphenol A (EXP,ISO)

cadmium dichloride (EXP,ISO)

copper(II) sulfate (ISO)

corosolic acid (ISO)

cyclosporin A (ISO)

dicrotophos (ISO)

doxorubicin (ISO)

fenthion (ISO)

finasteride (EXP)

folic acid (ISO)

furan (EXP)

methapyrilene (ISO)

oxaliplatin (EXP)

ozone (ISO)

paracetamol (EXP,ISO)

PCB138 (EXP)

potassium chromate (ISO)

quercetin (ISO)

sulindac (EXP)

thapsigargin (ISO)

thioacetamide (EXP)

topotecan (EXP)

tunicamycin (ISO)

urethane (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

mitochondrial tRNA 5'-end processing (IBA,ISO,ISS)

tRNA 5'-leader removal (IBA)

tRNA processing (IEA)

Cellular Component

mitochondrial nucleoid (ISO)

mitochondrial ribonuclease P complex (IBA,ISO,ISS)

mitochondrion (IEA,ISO)

nucleoplasm (IEA,ISO)

Molecular Function

metal ion binding (IEA)

nuclease activity (IEA)

ribonuclease P activity (IBA,ISO,ISS)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:12477932	PMID:18984158	PMID:24703694	PMID:25953853

Genomics

Comparative Map Data

Prorp
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	6	78,404,821 - 78,497,562 (+)	NCBI		GRCr8
mRatBN7.2	6	72,669,659 - 72,762,419 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	6	72,670,847 - 72,762,416 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	6	73,093,590 - 73,182,668 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	6	73,399,942 - 73,489,024 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	6	72,828,549 - 72,917,703 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	6	76,079,880 - 76,171,298 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	6	76,079,880 - 76,171,296 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	6	85,614,276 - 85,708,817 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	6	75,539,870 - 75,633,118 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	6	75,543,495 - 75,636,184 (+)	NCBI
Celera	6	71,512,144 - 71,602,932 (+)	NCBI		Celera
Cytogenetic Map	6	q23	NCBI

PRORP
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	14	35,121,839 - 35,277,622 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	14	35,121,846 - 35,277,622 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	14	35,591,045 - 35,746,828 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	14	34,661,527 - 34,813,022 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	14	15,455,607 - 15,607,100 (+)	NCBI		Celera
Cytogenetic Map	14	q13.2	NCBI
HuRef	14	15,704,222 - 15,857,638 (+)	NCBI		HuRef
CHM1_1	14	35,591,261 - 35,743,020 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	14	29,318,793 - 29,465,226 (+)	NCBI		T2T-CHM13v2.0

Prorp
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	12	55,349,422 - 55,429,276 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	12	55,346,362 - 55,429,318 (+)	Ensembl		GRCm39 Ensembl
GRCm38	12	55,302,637 - 55,382,492 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	12	55,299,577 - 55,382,533 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	12	56,403,624 - 56,483,478 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	12	56,220,753 - 56,300,617 (+)	NCBI		MGSCv36	mm8
Celera	12	56,446,616 - 56,531,738 (+)	NCBI		Celera
Cytogenetic Map	12	C1	NCBI
cM Map	12	23.91	NCBI

Prorp
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955409	25,791,575 - 25,920,077 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955409	25,791,209 - 25,920,651 (-)	NCBI	ChiLan1.0	ChiLan1.0

PRORP
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	15	36,432,152 - 36,590,190 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	14	35,648,655 - 35,808,108 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	14	15,871,707 - 16,027,634 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	14	34,056,234 - 34,209,657 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	14	34,056,620 - 34,209,657 (+)	Ensembl	panpan1.1		panPan2

PRORP
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	8	13,885,734 - 14,007,224 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	8	13,681,902 - 13,803,857 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	8	13,991,929 - 14,113,298 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	8	13,992,144 - 14,113,292 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	8	13,693,596 - 13,814,946 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	8	13,758,157 - 13,879,746 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	8	14,047,450 - 14,169,639 (+)	NCBI		UU_Cfam_GSD_1.0

Prorp
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	45,776,936 - 45,908,465 (+)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936494	9,282,894 - 9,414,350 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PRORP
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	7	64,620,517 - 64,762,428 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	7	64,620,514 - 64,763,272 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	7	69,530,089 - 69,535,675 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

PRORP
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	24	11,936,410 - 12,081,721 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	24	11,936,410 - 12,083,519 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666053	897,654 - 1,044,936 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Variants

Variants in Prorp
636 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	42
Count of miRNA genes:	41
Interacting mature miRNAs:	42
Transcripts:	ENSRNOT00000009304
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
9590290	Uminl2	Urine mineral level QTL 2	3.96	0.001	urine mineral amount (VT:0015086)	urine electrolyte level (CMO:0000593)	6	38783989	83783989	Rat
1331799	Bp211	Blood pressure QTL 211	3.66407		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	6	72202632	130919985	Rat
634307	Bp141	Blood pressure QTL 141	4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	6	35230417	80230417	Rat
634330	Pia16	Pristane induced arthritis QTL 16	3.9		joint integrity trait (VT:0010548)	arthritic paw count (CMO:0001460)	6	45790088	104200226	Rat
1331789	Rf37	Renal function QTL 37	3.224		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal vascular resistance (CMO:0001900)	6	72202632	115200186	Rat
4145119	Mcs25	Mammary carcinoma susceptibility QTL 25		0.0001	mammary gland integrity trait (VT:0010552)	ratio of deaths to total study population during a period of time (CMO:0001023)	6	10894415	110548006	Rat
70176	Mcsm1	Mammary carcinoma susceptibility modifier QTL 1			mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	6	58632962	103632962	Rat
1581563	Uae33	Urinary albumin excretion QTL 33			urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	6	72227641	130729205	Rat
1558641	Cm47	Cardiac mass QTL 47	2.9	0.001	heart mass (VT:0007028)	heart wet weight (CMO:0000069)	6	57730540	104085867	Rat
1641904	Alcrsp4	Alcohol response QTL 4			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	6	67262953	112262953	Rat
2293839	Kiddil2	Kidney dilation QTL 2	4.8		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	6	20866422	81133036	Rat
1576309	Emca7	Estrogen-induced mammary cancer QTL 7	4		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	6	15107216	107351382	Rat
731173	Uae22	Urinary albumin excretion QTL 22	10.1		urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	6	65531555	140994061	Rat
9590140	Scort4	Serum corticosterone level QTL 4	14.49	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	6	38783989	83783989	Rat
2301964	Bp323	Blood pressure QTL 323	4.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	6	72227641	81132889	Rat
9590306	Scort18	Serum corticosterone level QTL 18	2.88	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	6	38783989	83783989	Rat
2293841	Kiddil4	Kidney dilation QTL 4	4.4		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	6	20866422	81133036	Rat
4889848	Pur25	Proteinuria QTL 25	14	0.003	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	6	56728562	90198260	Rat
724536	Uae7	Urinary albumin excretion QTL 7	3.5		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	6	72202632	130729475	Rat
70196	BpQTLcluster7	Blood pressure QTL cluster 7	6.82		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	6	72202632	117202632	Rat
6893340	Cm77	Cardiac mass QTL 77	0.26	0.57	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	6	33309549	81132889	Rat
1581550	Pur8	Proteinuria QTL 8			urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	6	72227641	130729205	Rat
1300075	Glom7	Glomerulus QTL 7	5.6	0.0000002	kidney glomerulus morphology trait (VT:0005325)	count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)	6	71201409	116201409	Rat
2290393	Uae37	Urinary albumin excretion QTL 37		0.0001	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	6	65531555	140994061	Rat
1300143	Rf14	Renal function QTL 14	2.92		renal blood flow trait (VT:2000006)	absolute change in renal blood flow rate (CMO:0001168)	6	34434137	77102317	Rat
12801471	Schws9	Schwannoma susceptibility QTL 9			nervous system integrity trait (VT:0010566)	percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)	6	61747639	106747639	Rat
6893332	Cm74	Cardiac mass QTL 74	0.4	0.64	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	6	57730540	104085867	Rat

Markers in Region

D6Got85

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	6	72,751,258 - 72,751,411 (+)	MAPPER	mRatBN7.2
Rnor_6.0	6	76,160,142 - 76,160,292	NCBI	Rnor6.0
Rnor_5.0	6	85,697,134 - 85,697,284	UniSTS	Rnor5.0
RGSC_v3.4	6	75,621,386 - 75,621,537	RGD	RGSC3.4
RGSC_v3.4	6	75,621,387 - 75,621,537	UniSTS	RGSC3.4
RGSC_v3.1	6	75,624,512 - 75,624,663	RGD
Celera	6	71,591,777 - 71,591,927	UniSTS
RH 2.0 Map	6	705.3	RGD
Cytogenetic Map	6	q23	UniSTS

RH137190

Rat Assembly	Chr	Position (strand)	Source
Celera	6	71,515,332 - 71,515,511	UniSTS
Celera	14	96,252,285 - 96,252,538	UniSTS
Cytogenetic Map	6	q23	UniSTS

RH139091

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	6	72,671,021 - 72,671,174 (+)	MAPPER	mRatBN7.2
Rnor_6.0	6	76,079,909 - 76,080,061	NCBI	Rnor6.0
Rnor_5.0	6	85,615,643 - 85,615,795	UniSTS	Rnor5.0
RGSC_v3.4	6	75,539,899 - 75,540,051	UniSTS	RGSC3.4
Celera	6	71,512,173 - 71,512,325	UniSTS
Cytogenetic Map	6	q23	UniSTS

AI407643

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	6	72,686,370 - 72,686,567 (+)	MAPPER	mRatBN7.2
Rnor_6.0	6	76,095,257 - 76,095,453	NCBI	Rnor6.0
Rnor_5.0	6	85,630,991 - 85,631,187	UniSTS	Rnor5.0
RGSC_v3.4	6	75,555,247 - 75,555,443	UniSTS	RGSC3.4
Celera	6	71,527,468 - 71,527,664	UniSTS
Cytogenetic Map	6	q23	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001106730	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039111975	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC115158	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC168878	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473947	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ230894	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000006	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000009304 ⟹ ENSRNOP00000009306

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	6	72,670,847 - 72,762,416 (+)	Ensembl
Rnor_6.0 Ensembl	6	76,079,880 - 76,171,296 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000100278 ⟹ ENSRNOP00000090601

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	6	72,671,506 - 72,762,416 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000115283 ⟹ ENSRNOP00000084560

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	6	72,670,847 - 72,760,162 (+)	Ensembl

RefSeq Acc Id:

NM_001106730 ⟹ NP_001100200

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	6	78,406,142 - 78,497,562 (+)	NCBI
mRatBN7.2	6	72,670,993 - 72,762,417 (+)	NCBI
Rnor_6.0	6	76,079,880 - 76,171,298 (+)	NCBI
Rnor_5.0	6	85,614,276 - 85,708,817 (+)	NCBI
RGSC_v3.4	6	75,539,870 - 75,633,118 (+)	RGD
Celera	6	71,512,144 - 71,602,932 (+)	RGD

Sequence:

show sequence

ATTCCCACCCCCTTCTCTGAAGAGTTTTGCGTCCTGGAGAGAGTTGTGAAAAGCAAGGAACCCT
AGACTGGCTTTTCTTGCTGCTGCTGGAACTACGGTTGGTGGTTCCTGACTGATTTTATTTATTT
TCGTGTTCTCGCTCCCGTGATATCCCGCCCCTCTTCAGGACCGTAGTAATCCGCAGGAGTTAAA
CTGGGAGGTCCATGTGCTTTTTCTTCAGATTCGAAAATTGGAAGGTAACAGGCACCTCAGGATT
TCCGTTCCGTCTTCTGGTTTAGGGATTGCTACTAGTGTTGGATGTCCTTGGATTGTTATTTAAT
GAATAGAACTCTTGTGCTTTCCTTCACATTAAATCGCTCCAAACATATAATCTTGGCTTGTTTA
TAAGGGAGAAACAAAAAAAAAAAAAAAATTCAAGAACTGGGCTTCCACTGTCTTCAGCCCTCAA
TACCTTAATTTTACATAGTGGAGTGAAGCTGTTTTTAGAAGTTGTCTCATTCAACTCACAGCAG
AATGACTTTCTATTTGTCTGGTTTTCGGAGCTTTCTGAAACTTTGGAAGAGCAACCCTTATTTT
GAACTAGGCCCTGCGACCTCTTCTGCCTCTTTCTTTCTCGGGGTTCACTGTGTCATCGGGAACC
AACAGAGATGGTTTTCTGTTAAACCTACCACCCCTCCAAATAGCAAAATACTCAATCTACTGGT
TACTAAAGCTAGAACACTCAAGAAAGGAAATGACAGCAATAAACAAGCTTCTTCTGGTCCTCAT
TATTTTGCTGCTGGAGAGGCTAAGAAGAGGTCCCACCTAAGTGGTAACCCTCAGAATCAAGGTC
ACACCTTGCCTGTGAAAAGCACTGTCCAACTCCCAACTAAACCTTTGAATTCCGAAGAGTGGGA
TAAACTTAAAGAAGATTTCAAAGGAAAGGCCAGTTTCGAAGACTTCGTCATTTCACAGATGACA
CGCAGCTGCAGTTCAGTCGATGTGGCCAAGTCTCTCCTGGCTTGGGTAGCAGCAAAGAACAATG
GTATCGTGGGGTATAATTTACTCGTCAAGTATTTATATCTCTGTGTCTTTCATAAGCAGACGTC
AGAAGTTATCGATGTCTACGAAATAATGAAAGCCAAGTACAAGAGTTTAGAATCTGGGGGTTAC
ACCCTTCTCATCCGGGGATTAATCCACTCAGACAGATGGAGAGAGGCCTTGTTGCTGTTAGAAG
ATATTAAAAAAGTCATGGTCCCTTCCAAAAAGAACTATGGTGACTGTATACAAGGAGCCCTCCT
TCATCAAGATGTGAACGTGGCTTGGAGTTTGTATCAGGAGTTGGTAGGTCATAATCTCATCCCT
CTGTTGGAAACTTTAAAAGCCTTCTTTGATCATGGCAAAGACATGAATGATGATCAGTATTCAA
ACCAACTCCTGGACATTCTTTTGTATCTAAGGAATAATCAGCTGTATCCTGGAGAGTCATTTGC
ACACAGTATAAAGACGTGGTTTGAAAGCATTCCTGGAAGACAATGGAAAGGACAGTTCACCACA
ATTCAGAAAAGTGGCCAGTGTTCAAGCTGTGGCAGAGCCATAGAGTCTATCCATCTGAGTCCAG
AAGAGTATGAATTTCTCAAGGAAACAATCATGAGAGATGTGATTGATGGTGGCGACCAGTACAA
GAAGACGACACCTCAGGAACTGAAGAGATTTGAGCGCTTTGTGAAGTCCTGTCCTCCTTTTGAT
ATTGTTATTGATGGCCTCAATGTTGCAAAAATGTTTCCTAAGGGTCGTGAATCTCAAAATCTCC
TGGGTATAGTTTCTCAACTGGCCCAGCAGAATCTACAGCTGCTGGTCCTGGGCCGGAAGCACAT
GCTGAGGCCCAGTTCCCAGTGGAGAAAGGACGAGATGGAGCAGGTGCGGAAGCAAGCCCACTGT
TTTTTTGCTGATAACATCTCGGAGGACGATCCTTTCCTTCTGTATGCCACACTGAACTCAGGCA
GTCACTGCAAGTTTATCACCAAAGACCTGTTGCGGGACCACAAGGCCTGCCTGCCTGATGCCCG
GGCTCAGCGCCTGTTCTTTAAGTGGCAGCAGGGCCATCAGCTGGCAATCACGAAAGGGTTTCTG
AAATCAAAACTAACCTTCCAGCATATTCTCAGCTATGACACTGTGGTGCAGACGACTGGAGACA
CCTGGCACATTCCTTATGATGAAGACCTGGTGCCGAGATCCTCCTGTGAAGTGCCCACCAAATG
GCTGTGCCTCCAGAGAAAGACCCCTGCCCCCTGCTGAGTCGTACTGGCCTGGCTTCCTGGCATG
ACCTGTGTTCTGGAAATAAAAGGATTTTAGTAAAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_039111975 ⟹ XP_038967903

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	6	78,404,821 - 78,497,562 (+)	NCBI
mRatBN7.2	6	72,669,659 - 72,762,419 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001100200	(Get FASTA)	NCBI Sequence Viewer
	XP_038967903	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAI68878	(Get FASTA)	NCBI Sequence Viewer
	B5DF07	(Get FASTA)	NCBI Sequence Viewer
	EDM03424	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000009306.4
	ENSRNOP00000084560.1
	ENSRNOP00000090601.1
	ENSRNOP00055018776
	ENSRNOP00060029301
	ENSRNOP00065005217

RefSeq Acc Id:	NP_001100200 ⟸ NM_001106730
- Peptide Label:	precursor
- UniProtKB:	B5DF07 (UniProtKB/Swiss-Prot), A0A8I6AEM3 (UniProtKB/TrEMBL)
- Sequence:	show sequence MTFYLSGFRSFLKLWKSNPYFELGPATSSASFFLGVHCVIGNQQRWFSVKPTTPPNSKILNLLV TKARTLKKGNDSNKQASSGPHYFAAGEAKKRSHLSGNPQNQGHTLPVKSTVQLPTKPLNSEEWD KLKEDFKGKASFEDFVISQMTRSCSSVDVAKSLLAWVAAKNNGIVGYNLLVKYLYLCVFHKQTS EVIDVYEIMKAKYKSLESGGYTLLIRGLIHSDRWREALLLLEDIKKVMVPSKKNYGDCIQGALL HQDVNVAWSLYQELVGHNLIPLLETLKAFFDHGKDMNDDQYSNQLLDILLYLRNNQLYPGESFA HSIKTWFESIPGRQWKGQFTTIQKSGQCSSCGRAIESIHLSPEEYEFLKETIMRDVIDGGDQYK KTTPQELKRFERFVKSCPPFDIVIDGLNVAKMFPKGRESQNLLGIVSQLAQQNLQLLVLGRKHM LRPSSQWRKDEMEQVRKQAHCFFADNISEDDPFLLYATLNSGSHCKFITKDLLRDHKACLPDAR AQRLFFKWQQGHQLAITKGFLKSKLTFQHILSYDTVVQTTGDTWHIPYDEDLVPRSSCEVPTKW LCLQRKTPAPC hide sequence

Ensembl Acc Id:

ENSRNOP00000009306 ⟸ ENSRNOT00000009304

RefSeq Acc Id:	XP_038967903 ⟸ XM_039111975
- Peptide Label:	isoform X1

Ensembl Acc Id:

ENSRNOP00000090601 ⟸ ENSRNOT00000100278

Ensembl Acc Id:

ENSRNOP00000084560 ⟸ ENSRNOT00000115283

Protein Domains

PRORP

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-B5DF07-F1-model_v2	AlphaFold	B5DF07	1-587	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1305089	AgrOrtholog
BioCyc Gene	G2FUF-37489	BioCyc
Ensembl Genes	ENSRNOG00000007043	Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ENSRNOG00055013489	UniProtKB/Swiss-Prot
	ENSRNOG00060020537	UniProtKB/Swiss-Prot
	ENSRNOG00065005134	UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000009304.5	UniProtKB/Swiss-Prot
	ENSRNOT00000100278.1	UniProtKB/TrEMBL
	ENSRNOT00000115283.1	UniProtKB/TrEMBL
	ENSRNOT00055023137	UniProtKB/Swiss-Prot
	ENSRNOT00060035635	UniProtKB/Swiss-Prot
	ENSRNOT00065007534	UniProtKB/Swiss-Prot
Gene3D-CATH	1.25.40.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	3.40.50.11980	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	MRPP3	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PRORP_C	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TPR-like_helical_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:299050	UniProtKB/Swiss-Prot
NCBI Gene	299050	ENTREZGENE
PANTHER	PTHR13547:SF1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	UNCHARACTERIZED	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	PRORP	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Prorp	PhenoGen
RatGTEx	ENSRNOG00000007043	RatGTEx
	ENSRNOG00055013489	RatGTEx
	ENSRNOG00060020537	RatGTEx
	ENSRNOG00065005134	RatGTEx
UniProt	A0A8I6A1L4_RAT	UniProtKB/TrEMBL
	A0A8I6AEM3	ENTREZGENE, UniProtKB/TrEMBL
	B5DF07	ENTREZGENE, UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2019-08-09	Prorp	protein only RNase P catalytic subunit	RGD1305089	similar to 1110008L16Rik protein	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	RGD1305089	similar to 1110008L16Rik protein	RGD1305089_predicted	similar to 1110008L16Rik protein (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-20	RGD1305089_predicted	similar to 1110008L16Rik protein (predicted)	LOC299050_predicted		Symbol and Name status set to approved	1331353	APPROVED
2005-01-12	LOC299050_predicted	similar to 1110008L16Rik protein (predicted)			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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