Cyfip2 (cytoplasmic FMR1 interacting protein 2) - Rat Genome Database

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Gene: Cyfip2 (cytoplasmic FMR1 interacting protein 2) Rattus norvegicus
Analyze
Symbol: Cyfip2
Name: cytoplasmic FMR1 interacting protein 2
RGD ID: 1305048
Description: Predicted to enable small GTPase binding activity. Predicted to be involved in several processes, including activation of cysteine-type endopeptidase activity; neuron projection morphogenesis; and positive regulation of neurotrophin TRK receptor signaling pathway. Predicted to be located in perinuclear region of cytoplasm. Predicted to be part of SCAR complex. Predicted to be active in neuron projection and synapse. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 65. Orthologous to human CYFIP2 (cytoplasmic FMR1 interacting protein 2); PARTICIPATES IN E-cadherin signaling pathway; platelet-derived growth factor signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene; 3,3',4,4',5-pentachlorobiphenyl.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC303073
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81031,122,653 - 31,242,440 (-)NCBIGRCr8
mRatBN7.21030,621,318 - 30,741,113 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1030,621,318 - 30,741,113 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1035,348,673 - 35,468,277 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0103,887,117 - 4,006,729 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01030,323,472 - 30,442,925 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01031,278,746 - 31,419,235 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1031,278,746 - 31,419,235 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01031,097,979 - 31,198,028 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41031,321,000 - 31,443,480 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11031,324,310 - 31,444,535 (-)NCBI
Celera1030,074,331 - 30,193,168 (-)NCBICelera
Cytogenetic Map10q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-alpha-phellandrene  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dinitrotoluene  (EXP)
2-butoxyethanol  (ISO)
2-methylcholine  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3-chloropropane-1,2-diol  (EXP)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrylamide  (EXP,ISO)
actinomycin D  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
alpha-phellandrene  (ISO)
alpha-Zearalanol  (EXP)
Ampullosporin  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
beta-lapachone  (ISO)
beta-naphthoflavone  (ISO)
bisphenol A  (EXP,ISO)
buta-1,3-diene  (ISO)
cadmium dichloride  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlordecone  (ISO)
choline  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper(II) chloride  (ISO)
coumestrol  (ISO)
cyclosporin A  (ISO)
DDE  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
dibenzofurans  (ISO)
dimethylarsinic acid  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
epoxiconazole  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
gentamycin  (EXP)
hydralazine  (ISO)
indole-3-methanol  (EXP)
ivermectin  (ISO)
ketamine  (EXP)
L-methionine  (ISO)
lead diacetate  (ISO)
leflunomide  (EXP)
methapyrilene  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-nitrosodiethylamine  (EXP)
nickel atom  (ISO)
Nutlin-3  (ISO)
oxaliplatin  (EXP)
paracetamol  (ISO)
permethrin  (EXP)
phenobarbital  (ISO)
pirinixic acid  (EXP,ISO)
piroxicam  (ISO)
poly(I:C)  (EXP)
potassium chromate  (ISO)
progesterone  (ISO)
propanal  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sulforaphane  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (EXP,ISO)
topotecan  (EXP)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (EXP,ISO)
triptonide  (ISO)
trovafloxacin  (ISO)
tungsten  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vinclozolin  (EXP)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10449408   PMID:11438699   PMID:15048733   PMID:18387192   PMID:19056867   PMID:19946888   PMID:20458337   PMID:21700703   PMID:23533145   PMID:27605705   PMID:33450132  


Genomics

Comparative Map Data
Cyfip2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81031,122,653 - 31,242,440 (-)NCBIGRCr8
mRatBN7.21030,621,318 - 30,741,113 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1030,621,318 - 30,741,113 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1035,348,673 - 35,468,277 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0103,887,117 - 4,006,729 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01030,323,472 - 30,442,925 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01031,278,746 - 31,419,235 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1031,278,746 - 31,419,235 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01031,097,979 - 31,198,028 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41031,321,000 - 31,443,480 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11031,324,310 - 31,444,535 (-)NCBI
Celera1030,074,331 - 30,193,168 (-)NCBICelera
Cytogenetic Map10q21NCBI
CYFIP2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385157,266,123 - 157,395,594 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5157,266,079 - 157,395,595 (+)EnsemblGRCh38hg38GRCh38
GRCh375156,693,133 - 156,822,602 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365156,625,669 - 156,755,184 (+)NCBINCBI36Build 36hg18NCBI36
Build 345156,628,929 - 156,752,793NCBI
Celera5152,719,640 - 152,849,168 (+)NCBICelera
Cytogenetic Map5q33.3NCBI
HuRef5151,780,753 - 151,910,647 (+)NCBIHuRef
CHM1_15156,125,748 - 156,255,279 (+)NCBICHM1_1
T2T-CHM13v2.05157,785,054 - 157,914,553 (+)NCBIT2T-CHM13v2.0
Cyfip2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391146,084,676 - 46,203,686 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1146,084,677 - 46,203,686 (-)EnsemblGRCm39 Ensembl
GRCm381146,193,849 - 46,312,859 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1146,193,850 - 46,312,859 (-)EnsemblGRCm38mm10GRCm38
MGSCv371146,007,360 - 46,125,852 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361146,037,281 - 46,155,773 (-)NCBIMGSCv36mm8
Celera1150,779,500 - 50,898,263 (-)NCBICelera
Cytogenetic Map11B1.1NCBI
cM Map1127.61NCBI
Cyfip2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540811,462,837 - 11,588,378 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540811,483,891 - 11,586,628 (+)NCBIChiLan1.0ChiLan1.0
CYFIP2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24152,461,545 - 152,591,293 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15150,601,092 - 150,730,844 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05152,667,136 - 152,796,575 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15159,288,779 - 159,418,077 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5159,292,029 - 159,418,077 (+)Ensemblpanpan1.1panPan2
CYFIP2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1452,769,638 - 52,875,080 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl452,743,048 - 52,880,589 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha452,661,797 - 52,785,745 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0453,206,203 - 53,330,066 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1453,032,652 - 53,138,139 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0453,139,468 - 53,263,349 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0453,656,324 - 53,780,306 (-)NCBIUU_Cfam_GSD_1.0
Cyfip2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213107,310,615 - 107,431,342 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365155,759,345 - 5,880,713 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365155,759,940 - 5,880,688 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CYFIP2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1665,852,588 - 66,001,559 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11665,852,584 - 66,001,576 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21671,707,184 - 71,865,915 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CYFIP2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12359,661,045 - 59,794,717 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2359,661,089 - 59,794,826 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603417,835,766 - 17,969,652 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cyfip2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473331,996,423 - 32,115,577 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473331,996,717 - 32,115,571 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cyfip2
903 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:339
Count of miRNA genes:197
Interacting mature miRNAs:244
Transcripts:ENSRNOT00000059496
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9589136Insul27Insulin level QTL 2710.460.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)101147401056474010Rat
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101527595560275955Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1074336463851208Rat
631557Bp136Blood pressure QTL 1360.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)103063205375632053Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10637574651375746Rat
2293680Bss40Bone structure and strength QTL 405.660.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)10135225947Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)10580199062146030Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1041834445418344Rat
1554317Bmd4Bone mineral density QTL 49.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)101981604299406971Rat
1598852Anxrr19Anxiety related response QTL 195.07body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)101816784163167841Rat
1581497Esta1Estrogen-induced thymic atrophy QTL 1thymus mass (VT:0004954)thymus wet weight (CMO:0000855)102132980561345413Rat
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
724527Bp148Blood pressure QTL 1480.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102845313673453136Rat
1331762Rf40Renal function QTL 403.873kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)102929950464155584Rat
2300171Bmd58Bone mineral density QTL 584.90.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)102694462871944628Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101448701189062041Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
9590310Scort19Serum corticosterone level QTL 196.30.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
10402859Bp381Blood pressure QTL 3810.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
6893352Bw100Body weight QTL 1000.330.6body mass (VT:0001259)body weight (CMO:0000012)11590666560906665Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102242750090627625Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10615418273453136Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10538701450387014Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)10538701450387014Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10180676123Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101502851360430477Rat
6893350Bw99Body weight QTL 990.870.16body mass (VT:0001259)body weight (CMO:0000012)11590666560906665Rat
70224Eae3Experimental allergic encephalomyelitis QTL 34.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)102652195761345413Rat
2298480Eau7Experimental allergic uveoretinitis QTL 70.0049uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)102795762634490668Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10538701450387014Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
2313087Bmd80Bone mineral density QTL 803.20.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)101960648364606483Rat
634327Hc4Hypercalciuria QTL 42.4urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)10138328221Rat
631531Iresp2Immunoglobin response QTL26.3blood immunoglobulin E amount (VT:0002492)serum immunoglobulin E level (CMO:0002101)102291826836400810Rat
631532Cm50Cardiac mass QTL 506.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)101790711351786432Rat
7411611Foco17Food consumption QTL 1718.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)10142315980Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
1600371Mcs21Mammary carcinoma susceptibility QTL 213mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)102887565052200160Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
9590268Scort13Serum corticosterone level QTL 133.260.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
2292441Bp308Blood pressure QTL 308arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
2313055Bw96Body weight QTL 963.60.0001body mass (VT:0001259)body weight (CMO:0000012)101960648364606483Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102652195798952741Rat

Markers in Region
D10Mgh19  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21030,631,492 - 30,631,600 (+)MAPPERmRatBN7.2
Rnor_6.01031,288,920 - 31,289,027NCBIRnor6.0
Rnor_5.01031,108,153 - 31,108,260UniSTSRnor5.0
RGSC_v3.41031,331,174 - 31,331,281UniSTSRGSC3.4
RGSC_v3.41031,331,173 - 31,331,281RGDRGSC3.4
RGSC_v3.11031,332,222 - 31,332,330RGD
Celera1030,084,505 - 30,084,605UniSTS
Cytogenetic Map10q21UniSTS
RH144330  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21030,639,067 - 30,639,256 (+)MAPPERmRatBN7.2
Rnor_6.01031,296,494 - 31,296,682NCBIRnor6.0
Rnor_5.01031,115,727 - 31,115,915UniSTSRnor5.0
RGSC_v3.41031,338,748 - 31,338,936UniSTSRGSC3.4
Celera1030,092,072 - 30,092,260UniSTS
RH 3.4 Map10319.5UniSTS
Cytogenetic Map10q21UniSTS
RH140277  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21030,621,441 - 30,621,661 (+)MAPPERmRatBN7.2
Rnor_6.01031,278,870 - 31,279,089NCBIRnor6.0
Rnor_5.01031,098,103 - 31,098,322UniSTSRnor5.0
RGSC_v3.41031,321,124 - 31,321,343UniSTSRGSC3.4
Celera1030,074,455 - 30,074,674UniSTS
RH 3.4 Map10340.7UniSTS
Cytogenetic Map10q21UniSTS
21STS02  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21030,621,322 - 30,621,519 (+)MAPPERmRatBN7.2
Rnor_6.01031,278,751 - 31,278,947NCBIRnor6.0
Rnor_5.01031,097,984 - 31,098,180UniSTSRnor5.0
RGSC_v3.41031,321,005 - 31,321,201UniSTSRGSC3.4
Celera1030,074,336 - 30,074,532UniSTS
Cytogenetic Map10q21UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000059496   ⟹   ENSRNOP00000056255
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1030,621,318 - 30,741,113 (-)Ensembl
Rnor_6.0 Ensembl1031,278,746 - 31,419,235 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000081280   ⟹   ENSRNOP00000068584
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1030,621,318 - 30,741,113 (-)Ensembl
Rnor_6.0 Ensembl1031,278,764 - 31,359,699 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000119958   ⟹   ENSRNOP00000094378
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1030,621,318 - 30,722,683 (-)Ensembl
RefSeq Acc Id: NM_001106996   ⟹   NP_001100466
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81031,122,653 - 31,242,440 (-)NCBI
mRatBN7.21030,621,318 - 30,741,113 (-)NCBI
Rnor_6.01031,278,746 - 31,419,235 (-)NCBI
Rnor_5.01031,097,979 - 31,198,028 (-)NCBI
RGSC_v3.41031,321,000 - 31,443,480 (-)RGD
Celera1030,074,331 - 30,193,168 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001100466 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM04166 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000056255.3
  ENSRNOP00000068584.2
  ENSRNOP00000094378.1
RefSeq Acc Id: NP_001100466   ⟸   NM_001106996
- UniProtKB: D3ZX82 (UniProtKB/TrEMBL),   A6HDR1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000056255   ⟸   ENSRNOT00000059496
Ensembl Acc Id: ENSRNOP00000068584   ⟸   ENSRNOT00000081280
Ensembl Acc Id: ENSRNOP00000094378   ⟸   ENSRNOT00000119958
Protein Domains
CYRIA/CYRIB Rac1 binding

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2JT63-F1-model_v2 AlphaFold A0A0G2JT63 1-967 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697124
Promoter ID:EPDNEW_R7649
Type:multiple initiation site
Name:Cyfip2_1
Description:cytoplasmic FMR1 interacting protein 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01031,419,236 - 31,419,296EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1305048 AgrOrtholog
BioCyc Gene G2FUF-25371 BioCyc
Ensembl Genes ENSRNOG00000006557 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000059496.5 UniProtKB/TrEMBL
  ENSRNOT00000081280.2 UniProtKB/TrEMBL
  ENSRNOT00000119958.1 UniProtKB/TrEMBL
InterPro CYRIA/CYRIB_Rac1-bd UniProtKB/TrEMBL
  Cytoplasmic_FMR1-int UniProtKB/TrEMBL
KEGG Report rno:303073 UniProtKB/TrEMBL
NCBI Gene 303073 ENTREZGENE
PANTHER CYTOPLASMIC FMR1-INTERACTING PROTEIN 2 UniProtKB/TrEMBL
  FragX_IP UniProtKB/TrEMBL
Pfam DUF1394 UniProtKB/TrEMBL
  FragX_IP UniProtKB/TrEMBL
PhenoGen Cyfip2 PhenoGen
PIRSF FMR1_interacting UniProtKB/TrEMBL
PRINTS CYTOFMRPINTP UniProtKB/TrEMBL
RatGTEx ENSRNOG00000006557 RatGTEx
UniProt A0A0G2JT63_RAT UniProtKB/TrEMBL
  A0A8I6AHL8_RAT UniProtKB/TrEMBL
  A6HDR1 ENTREZGENE, UniProtKB/TrEMBL
  D3ZX82 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Cyfip2  cytoplasmic FMR1 interacting protein 2   Cyfip2_predicted  cytoplasmic FMR1 interacting protein 2 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Cyfip2_predicted  cytoplasmic FMR1 interacting protein 2 (predicted)      Symbol and Name status set to approved 70820 APPROVED