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Gene: Tnks2 (tankyrase 2) Rattus norvegicus

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Symbol:

Tnks2

Name:

tankyrase 2

RGD ID:

1305026

Description:

Predicted to enable NAD+ poly-ADP-ribosyltransferase activity; NAD+-protein mono-ADP-ribosyltransferase activity; and enzyme binding activity. Predicted to be involved in several processes, including positive regulation of canonical Wnt signaling pathway; post-translational protein modification; and regulation of telomere maintenance. Predicted to act upstream of or within regulation of growth. Predicted to be located in nuclear envelope; pericentriolar material; and perinuclear region of cytoplasm. Predicted to be active in cytoplasm and nucleus. Orthologous to human TNKS2 (tankyrase 2); PARTICIPATES IN ADP-ribosylation pathway, mono and poly-ribosylation; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene; 3-chloropropane-1,2-diol.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

LOC100910717; LOC309512; poly [ADP-ribose] polymerase tankyrase-2; tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2; tankyrase-2; tankyrase-2-like

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	TNKS2 (tankyrase 2)	RGD	RGD
Mus musculus (house mouse):	Tnks2 (tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2)	RGD	RGD
Chinchilla lanigera (long-tailed chinchilla):	Tnks2 (tankyrase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	TNKS2 (tankyrase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	TNKS2 (tankyrase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Tnks2 (tankyrase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	TNKS2 (tankyrase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	TNKS2 (tankyrase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Tnks2 (tankyrase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	TNKS2 (tankyrase 2)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Tnks2 (tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Tnks	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Tnks	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	tnks2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	243,980,432 - 244,033,629 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	1	243,980,414 - 244,033,634 (+)	Ensembl				GRCr8
mRatBN7.2	1	234,567,888 - 234,621,079 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	234,567,858 - 234,621,079 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	1	242,957,470 - 243,010,368 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	249,885,628 - 249,938,508 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	242,723,807 - 242,776,700 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	255,478,794 - 255,532,143 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	255,479,261 - 255,532,143 (+)	NCBI			rn6	Rnor6.0
Rnor_6.0 Ensembl	1	255,479,261 - 255,532,143 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	1	262,953,201 - 263,006,973 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	1	241,112,141 - 241,164,804	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	1	231,660,758 - 231,713,638	NCBI		Celera
RGSC_v3.1	1	241,253,368 - 241,345,984	NCBI
Cytogenetic Map	1	q53	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

1,2-dimethylhydrazine (ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,6-dinitrotoluene (EXP)

2-hydroxypropanoic acid (ISO)

3-chloropropane-1,2-diol (EXP)

3H-1,2-dithiole-3-thione (EXP)

4,4'-sulfonyldiphenol (ISO)

aflatoxin B1 (ISO)

arsenite(3-) (ISO)

arsenous acid (ISO)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP)

bisphenol AF (EXP)

caffeine (EXP)

carbon nanotube (ISO)

chromium(6+) (ISO)

cisplatin (ISO)

clofibric acid (EXP)

cyclosporin A (ISO)

cyproconazole (ISO)

diarsenic trioxide (ISO)

Dibutyl phosphate (ISO)

dibutyl phthalate (EXP)

dicrotophos (ISO)

diuron (EXP)

dorsomorphin (ISO)

epoxiconazole (ISO)

ethanol (ISO)

ethyl methanesulfonate (ISO)

fenthion (ISO)

geldanamycin (ISO)

gentamycin (EXP)

methidathion (ISO)

methoxyacetic acid (EXP)

methyl methanesulfonate (ISO)

methylmercury chloride (EXP,ISO)

Monobutylphthalate (EXP)

N-nitrosodiethylamine (EXP)

nitrofen (EXP)

paracetamol (ISO)

perfluorooctane-1-sulfonic acid (ISO)

perfluorooctanoic acid (EXP)

phenobarbital (ISO)

poly(I:C) (EXP)

pregnenolone 16alpha-carbonitrile (EXP)

propiconazole (ISO)

rac-lactic acid (ISO)

resveratrol (ISO)

rotenone (EXP)

rucaparib (ISO)

SB 431542 (ISO)

sodium arsenite (ISO)

Soman (EXP)

succimer (ISO)

sunitinib (ISO)

titanium dioxide (ISO)

triphenyl phosphate (ISO)

troglitazone (ISO)

valproic acid (ISO)

vinclozolin (EXP)

XAV939 (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

biological_process (ND)

multicellular organism growth (ISO)

negative regulation of telomere maintenance via telomere lengthening (IEA,ISO)

positive regulation of canonical Wnt signaling pathway (IBA,IEA,ISO)

positive regulation of telomere capping (IBA,IEA,ISO)

protein auto-ADP-ribosylation (IEA,ISO)

protein localization to chromosome, telomeric region (IBA,IEA,ISO)

protein poly-ADP-ribosylation (IEA,ISO)

protein polyubiquitination (IEA,ISO)

regulation of multicellular organism growth (ISO)

telomere maintenance (ISO)

Wnt signaling pathway (IEA)

Cellular Component

chromosome (IEA)

chromosome, telomeric region (IEA)

cytoplasm (IBA,IEA,ISO)

Golgi apparatus (IEA)

Golgi membrane (IEA)

membrane (IEA)

nuclear envelope (IEA,ISO)

nucleus (IBA,IEA,ISO)

pericentriolar material (IEA,ISO)

perinuclear region of cytoplasm (IEA,ISO)

Molecular Function

enzyme binding (IEA,ISO)

glycosyltransferase activity (IEA)

metal ion binding (IEA)

NAD+ poly-ADP-ribosyltransferase activity (IBA,IEA,ISO)

NAD+-protein mono-ADP-ribosyltransferase activity (IEA,ISO)

nucleotidyltransferase activity (IEA)

protein binding (IPI,ISO)

transferase activity (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

ADP-ribosylation pathway, mono and poly-ribosylation (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Structures and Mechanisms of Enzymes Employed in the Synthesis and Degradation of PARP-Dependent Protein ADP-Ribosylation.	Barkauskaite E, etal., Mol Cell. 2015 Jun 18;58(6):935-46. doi: 10.1016/j.molcel.2015.05.007.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Tankyrase inhibition aggravates kidney injury in the absence of CD2AP.	Kuusela S, etal., Cell Death Dis. 2016 Jul 21;7:e2302. doi: 10.1038/cddis.2016.217.
4.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
5.	GOA pipeline	RGD automated data pipeline
6.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
8.	Comprehensive gene review and curation	RGD comprehensive gene curation

Additional References at PubMed

PMID:11278563	PMID:11454873	PMID:11739745	PMID:16507984	PMID:16507985	PMID:19759537	PMID:21251231	PMID:21478859	PMID:21531765	PMID:25043379	PMID:25939383

Genomics

Comparative Map Data

Tnks2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	243,980,432 - 244,033,629 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	1	243,980,414 - 244,033,634 (+)	Ensembl				GRCr8
mRatBN7.2	1	234,567,888 - 234,621,079 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	234,567,858 - 234,621,079 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	1	242,957,470 - 243,010,368 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	249,885,628 - 249,938,508 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	242,723,807 - 242,776,700 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	255,478,794 - 255,532,143 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	255,479,261 - 255,532,143 (+)	NCBI			rn6	Rnor6.0
Rnor_6.0 Ensembl	1	255,479,261 - 255,532,143 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	1	262,953,201 - 263,006,973 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	1	241,112,141 - 241,164,804	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	1	231,660,758 - 231,713,638	NCBI		Celera
RGSC_v3.1	1	241,253,368 - 241,345,984	NCBI
Cytogenetic Map	1	q53	NCBI

TNKS2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	10	91,798,426 - 91,865,475 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	10	91,798,426 - 91,865,475 (+)	Ensembl			hg38	GRCh38
GRCh37	10	93,558,183 - 93,625,232 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	10	93,548,049 - 93,615,012 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	10	93,548,048 - 93,615,012	NCBI
Celera	10	87,301,773 - 87,368,904 (+)	NCBI		Celera
Cytogenetic Map	10	q23.32	NCBI
HuRef	10	87,186,894 - 87,254,191 (+)	NCBI		HuRef
CHM1_1	10	93,839,907 - 93,906,988 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	10	92,681,611 - 92,748,788 (+)	NCBI		T2T-CHM13v2.0

Tnks2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	19	36,811,583 - 36,870,877 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	19	36,811,632 - 36,870,877 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	19	36,834,129 - 36,893,477 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	19	36,834,232 - 36,893,477 (+)	Ensembl			mm10	GRCm38
MGSCv37	19	36,908,722 - 36,967,967 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	19	36,832,583 - 36,958,617 (+)	NCBI		MGSCv36	mm8
Celera	19	37,609,652 - 37,668,932 (+)	NCBI		Celera
Cytogenetic Map	19	C2	NCBI
cM Map	19	31.96	NCBI

Tnks2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955425	1,417,679 - 1,492,267 (-)	Ensembl
ChiLan1.0	NW_004955425	1,419,013 - 1,492,267 (-)	NCBI	ChiLan1.0	ChiLan1.0

TNKS2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	8	103,837,790 - 103,903,675 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	10	103,843,094 - 103,908,990 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	10	88,547,396 - 88,612,973 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	10	92,070,362 - 92,134,911 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	10	92,070,362 - 92,134,911 (+)	Ensembl			panPan2	panpan1.1

TNKS2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	28	6,286,125 - 6,354,284 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	28	6,285,690 - 6,352,317 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	28	6,462,048 - 6,530,287 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	28	6,540,024 - 6,608,295 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	28	6,539,063 - 6,608,204 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	28	6,266,668 - 6,334,898 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	28	6,299,503 - 6,367,799 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	28	6,463,794 - 6,532,479 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Tnks2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	41,142,964 - 41,205,100 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936601	2,776,345 - 2,837,707 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936601	2,776,338 - 2,837,703 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

TNKS2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	14	103,396,459 - 103,461,821 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	14	103,396,424 - 103,461,830 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	14	112,909,835 - 112,975,236 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

TNKS2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	9	85,074,228 - 85,140,761 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	9	85,074,667 - 85,143,054 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666048	45,805,170 - 45,871,377 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Tnks2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624737	3,059,265 - 3,136,105 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624737	3,059,222 - 3,136,104 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Variants

Variants in Tnks2
98 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	646
Count of miRNA genes:	296
Interacting mature miRNAs:	386
Transcripts:	ENSRNOT00000039942, ENSRNOT00000075210
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1578778	Pur4	Proteinuria QTL 4	3.3	0.003	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	1	160111531	262090437	Rat
1354646	Kidm18	Kidney mass QTL 18	5.7		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	1	160573753	266453731	Rat
1357335	Bw39	Body weight QTL 39	3.3		body mass (VT:0001259)	body weight (CMO:0000012)	1	207243873	252243873	Rat
1354652	Kidm20	Kidney mass QTL 20	4.3		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	1	186658830	266453731	Rat
2293674	Bss39	Bone structure and strength QTL 39	7.1	0.0001	femur strength trait (VT:0010010)	femur total energy absorbed before break (CMO:0001677)	1	210980612	255980612	Rat
61455	Niddm7	Non-insulin dependent diabetes mellitus QTL 7	5.5		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	1	223964326	248681945	Rat
61327	Eae7	Experimental allergic encephalomyelitis QTL 7	5.6		body mass (VT:0001259)	change in body weight (CMO:0002045)	1	226175591	270518180	Rat
1600395	Niddm69	Non-insulin dependent diabetes mellitus QTL 69	4.14	0.0002	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	1	205233991	267096252	Rat
1578763	Kidm29	Kidney mass QTL 29	3.3	0.0001	kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	1	218829748	263829748	Rat
1354624	Cm35	Cardiac mass QTL35	5.7		heart left ventricle mass (VT:0007031)	calculated heart weight (CMO:0000073)	1	186658830	266453731	Rat
1600396	Niddm68	Non-insulin dependent diabetes mellitus QTL 68	4.97	0.0003	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	1	205233991	267096252	Rat
1600397	Edcs4	Endometrial carcinoma susceptibility QTL 4	2.2		uterus morphology trait (VT:0001120)	percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)	1	176288899	270518180	Rat
1549837	Hcar15	Hepatocarcinoma resistance QTL 15		0.05	liver integrity trait (VT:0010547)	liver tumorous lesion number (CMO:0001068)	1	162548015	270518180	Rat
152025235	Bw194	Body weight QTL 194	4.86		body mass (VT:0001259)		1	132966869	252856240	Rat
1600388	Niddm67	Non-insulin dependent diabetes mellitus QTL 67	5.84	0.000004	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	1	205233991	267096252	Rat
2293694	Bss38	Bone structure and strength QTL 38	7.05	0.0001	femur strength trait (VT:0010010)	femur stiffness (CMO:0001674)	1	210980612	255980612	Rat
1598853	Memor3	Memory QTL 3	4.5		exploratory behavior trait (VT:0010471)	total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)	1	152919152	268496042	Rat
1578759	Uae30	Urinary albumin excretion QTL 30	3.3	0.003	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	1	160111531	262090437	Rat
1300108	Rf8	Renal function QTL 8	3.75		renal blood flow trait (VT:2000006)	absolute change in renal vascular resistance (CMO:0001900)	1	237995023	269633915	Rat
734767	Niddm57	Non-insulin dependent diabetes mellitus QTL 57			body mass (VT:0001259)	body weight (CMO:0000012)	1	233480549	270108840	Rat
1358898	Bp255	Blood pressure QTL 255	3.6		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	200449456	256003563	Rat
631215	Stl8	Serum triglyceride level QTL 8	9.27	0.0001	blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	1	234540191	270518180	Rat
631843	Bw116	Body weight QTL 116	4.1	0.016	abdominal adipose amount (VT:1000220)	abdominal fat pad weight (CMO:0000088)	1	233480549	270108840	Rat
731175	Uae20	Urinary albumin excretion QTL 20	3.5	0.0018	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	1	207163993	269633915	Rat
2300175	Bmd40	Bone mineral density QTL 40	15.4	0.0001	femur mineral mass (VT:0010011)	bone mineral density (CMO:0001226)	1	210980612	255980612	Rat
1354661	Bw33	Body weight QTL 33	5.2		body mass (VT:0001259)	body weight (CMO:0000012)	1	160573753	266453731	Rat
724538	Kidm1	Kidney mass QTL 1	3.2		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	1	223134011	262090599	Rat
2293655	Bss36	Bone structure and strength QTL 36	10.66	0.0001	femur strength trait (VT:0010010)	femur ultimate force (CMO:0001675)	1	210980612	255980612	Rat
1298084	Thym4	Thymus enlargement QTL 4	10.68		thymus mass (VT:0004954)	thymus weight to body weight ratio (CMO:0000612)	1	207243873	252243873	Rat
724531	Uae5	Urinary albumin excretion QTL 5	4		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	1	160111426	262090599	Rat
2314011	Gluco56	Glucose level QTL 56			blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	1	209203273	254203273	Rat
8552891	Epfw5	Epididymal fat weight QTL 5	4.4		epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	1	202543537	247543537	Rat
734769	Niddm58	Non-insulin dependent diabetes mellitus QTL 58			body mass (VT:0001259)	body weight (CMO:0000012)	1	225108840	270108840	Rat
724533	Rf51	Renal function QTL 51	5.3	0.0002	kidney plasma flow trait (VT:0005524)	renal plasma flow (CMO:0001914)	1	228180370	266453608	Rat
1354580	Scort1	Serum corticosterone level QTL 1	3.4		blood corticosterone amount (VT:0005345)	blood corticosterone level (CMO:0001172)	1	154961463	266453731	Rat
1358292	Cm37	Cardiac mass QTL 37	6.2	8e-07	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	1	205674651	250674651	Rat
61376	Bp42	Blood pressure QTL 42	23.4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	207243873	252243873	Rat
634313	Niddm43	Non-insulin dependent diabetes mellitus QTL 43			blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	208479811	269633915	Rat
70211	Niddm24	Non-insulin dependent diabetes mellitus QTL 24	3.79		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	1	224633915	269633915	Rat
724552	Glom2	Glomerulus QTL 2	3.3	0.0001	kidney glomerulus morphology trait (VT:0005325)	count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)	1	232312773	270518180	Rat
2316896	Gluco57	Glucose level QTL 57	7.2		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	238398865	255849249	Rat
1358916	Kidm22	Kidney mass QTL 22	3.32		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	1	212738576	257738576	Rat
2312564	Glom18	Glomerulus QTL 18	2.4	0.003	kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	1	194786607	262083703	Rat
634321	Hc1	Hypercalciuria QTL 1	2.91		urine calcium amount (VT:0002985)	urine calcium excretion rate (CMO:0000763)	1	188241285	250779312	Rat
2292218	Kidm35	Kidney mass QTL 35			kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	1	208798288	253798288	Rat
61400	Niddm1	Non-insulin dependent diabetes mellitus QTL 1	11		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	228180243	255849249	Rat
61403	Niddm4	Non-insulin dependent diabetes mellitus QTL 4			blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	1	201464383	246464383	Rat
1641926	Teswt2	Testicular weight QTL 2	2.82		testis mass (VT:1000644)	both testes wet weight (CMO:0000175)	1	203675682	248675682	Rat
631658	Cm7	Cardiac mass QTL 7	5.32	0.0001	aorta mass (VT:0002845)	aorta weight (CMO:0000076)	1	205674651	250674651	Rat
1354610	Bw34	Body weight QTL 34	4.1		body mass (VT:0001259)	body weight (CMO:0000012)	1	160573753	266453731	Rat
2293700	Bmd27	Bone mineral density QTL 27	6.6	0.0001	femur mineral mass (VT:0010011)	trabecular volumetric bone mineral density (CMO:0001729)	1	210980612	255980612	Rat
2293701	Bmd34	Bone mineral density QTL 34	8.3	0.0001	femur strength trait (VT:0010010)	femoral neck ultimate force (CMO:0001703)	1	210980612	255980612	Rat
7387289	Uae45	Urinary albumin excretion QTL 45	2.86	0.0021	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	1	233204160	270518180	Rat
1600374	Mcs17	Mammary carcinoma susceptibility QTL 17	3		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	1	207099883	252099883	Rat
1581544	Rf52	Renal function QTL 52		0.05	urine total protein amount (VT:0000032)	urine protein excretion rate to body weight ratio (CMO:0001099)	1	241569529	269633915	Rat
1600363	Hc6	Hypercalciuria QTL 6	2.7		urine calcium amount (VT:0002985)	urine calcium excretion rate (CMO:0000763)	1	210980612	255980612	Rat
631536	Lnnr2	Liver neoplastic nodule remodeling QTL 2	2.9	0.0005	liver integrity trait (VT:0010547)	liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)	1	243953669	270518180	Rat
738032	Hcas5	Hepatocarcinoma susceptibility QTL 5	3.12		liver integrity trait (VT:0010547)	liver tumorous lesion number (CMO:0001068)	1	185857683	270518180	Rat
2302040	Pia35	Pristane induced arthritis QTL 35	3.8	0.001	blood immunoglobulin amount (VT:0002460)	serum immunoglobulin G1 level (CMO:0002115)	1	226175591	270518180	Rat
631669	Iddm9	Insulin dependent diabetes mellitus QTL 9	2.8	0.039	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	1	233349180	270518180	Rat
7394701	Uae46	Urinary albumin excretion QTL 46	3.6	0.0056	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	1	210980612	255980612	Rat
1598821	Rf55	Renal function QTL 55	6.3		renal blood flow trait (VT:2000006)	ratio of change in renal blood flow to change in renal perfusion pressure (CMO:0001239)	1	228174566	270518180	Rat

Markers in Region

RH130135

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	1	234,620,261 - 234,620,471 (+)	MAPPER	mRatBN7.2
Rnor_6.0	1	255,531,326 - 255,531,535	NCBI	Rnor6.0
Rnor_5.0	1	263,006,156 - 263,006,365	UniSTS	Rnor5.0
Rnor_5.0	1	262,829,184 - 262,829,393	UniSTS	Rnor5.0
RGSC_v3.4	1	241,163,987 - 241,164,196	UniSTS	RGSC3.4
Celera	1	231,712,821 - 231,713,030	UniSTS
RH 3.4 Map	1	1583.2	UniSTS
Cytogenetic Map	1	q53	UniSTS

BF386861

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	1	234,618,677 - 234,618,837 (+)	MAPPER	mRatBN7.2
Rnor_6.0	1	255,529,742 - 255,529,901	NCBI	Rnor6.0
Rnor_5.0	1	263,004,572 - 263,004,731	UniSTS	Rnor5.0
Rnor_5.0	1	262,827,600 - 262,827,759	UniSTS	Rnor5.0
RGSC_v3.4	1	241,162,403 - 241,162,562	UniSTS	RGSC3.4
Celera	1	231,711,237 - 231,711,396	UniSTS
RH 3.4 Map	1	1584.4	UniSTS
Cytogenetic Map	1	q53	UniSTS

BF394203

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	1	234,588,842 - 234,589,006 (+)	MAPPER	mRatBN7.2
Rnor_6.0	1	255,499,911 - 255,500,074	NCBI	Rnor6.0
Rnor_5.0	1	262,974,127 - 262,974,290	UniSTS	Rnor5.0
Rnor_5.0	1	262,797,770 - 262,797,933	UniSTS	Rnor5.0
RGSC_v3.4	1	241,132,571 - 241,132,734	UniSTS	RGSC3.4
Celera	1	231,681,408 - 231,681,571	UniSTS
RH 3.4 Map	1	1583.0	UniSTS
Cytogenetic Map	1	q53	UniSTS

AI599623

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	1	234,608,259 - 234,608,400 (+)	MAPPER	mRatBN7.2
Rnor_6.0	1	255,519,325 - 255,519,465	NCBI	Rnor6.0
Rnor_5.0	1	262,993,998 - 262,994,138	UniSTS	Rnor5.0
Rnor_5.0	1	262,817,184 - 262,817,324	UniSTS	Rnor5.0
RGSC_v3.4	1	241,151,985 - 241,152,125	UniSTS	RGSC3.4
Celera	1	231,700,822 - 231,700,962	UniSTS
RH 3.4 Map	1	1582.8	UniSTS
Cytogenetic Map	1	q53	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
22	13	73	197	125	121	77	99	77	12	416	218	11	164	91	111	44	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001107607	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039080633	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039080634	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063265190	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH473953	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000001	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000079808 ⟹ ENSRNOP00000068637

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	1	243,980,414 - 244,033,634 (+)	Ensembl
mRatBN7.2 Ensembl	1	234,567,858 - 234,621,079 (+)	Ensembl
Rnor_6.0 Ensembl	1	255,479,261 - 255,532,143 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000085497 ⟹ ENSRNOP00000073499

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	1	243,980,437 - 244,033,626 (+)	Ensembl
mRatBN7.2 Ensembl	1	234,567,858 - 234,621,079 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000132955 ⟹ ENSRNOP00000098656

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	1	243,980,511 - 244,033,057 (+)	Ensembl

RefSeq Acc Id:

NM_001107607 ⟹ NP_001101077

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	243,980,746 - 244,033,629 (+)	NCBI
mRatBN7.2	1	234,568,190 - 234,621,079 (+)	NCBI
Rnor_5.0	1	262,953,201 - 263,006,973 (+)	NCBI
RGSC_v3.4	1	241,112,141 - 241,164,804 (+)	RGD
Celera	1	231,660,758 - 231,713,638 (+)	RGD

Sequence:

show sequence

ATGTCTGGCCGCCGCTGCGCCGGCGGGGGCGCGGCCTGCTCGAGCGCGGTGGCGGAGGCCGTAG
AGCCGTCCGCCCGCGAACTGTTCGAGGCTTGCCGCAACGGGGACGTAGAGCGAGTGAAGAGGCT
GGTGACGCCCGAGAAGGTGAACAGCCGCGACACGGCGGGCAGGAAGTCCACCCCGCTCCACTTC
GCCGCAGGTTTTGGTCGGAAGGATGTAGTTGAGTATCTGCTTCAGAATGGTGCAAATGTGCAAG
CCCGTGATGACGGAGGTCTTATTCCTCTTCATAACGCATGCTCTTTTGGTCATGCTGAAGTAGT
CAATCTTCTTTTGCAACATGGTGCAGACCCAAATGCCCGGGATAATTGGAATTATACTCCTCTC
CATGAAGCTGCAATTAAAGGAAAAATTGATGTTTGCATTGTGCTTTTACAGCATGGAGCTGAGC
CAACCATCCGAAATACAGATGGAAGGACAGCATTGGATTTAGCAGACCCATCCGCCAAAGCTGT
TCTGACCGGTGACTATAAGAAAGATGAACTCTTGGAAAGTGCCAGGAGTGGCAATGAGGAGAAA
ATGATGGCTCTGCTTACACCACTGAATGTCAACTGCCATGCAAGTGATGGCAGAAAGTCAACTC
CATTGCATTTGGCAGCAGGATACAACAGAGTAAAAATTGTCCAACTGTTACTGCAACATGGAGC
AGATGTCCATGCTAAGGATAAAGGTGATCTGGTACCATTACACAACGCCTGCTCCTACGGTCAT
TATGAAGTAACTGAACTTCTGGTCAAGCATGGTGCCTGTGTAAATGCAATGGATTTGTGGCAAT
TTACTCCTCTTCATGAGGCAGCTTCTAAGAACAGGGTTGAAGTGTGTTCTCTTCTCCTAAGTTA
TGGGGCAGATCCAACCCTGCTGAACTGTCACAATAAGAGTGCTATAGACCTGGCCCCCACAGCA
CAGCTGAAGGAAAGATTATCGTATGAGTTTAAAGGCCATTCATTGCTGCAAGCTGCACGAGAAG
CTGATGTTACAAGAATCAAAAAACATCTTTCTCTGGAAATGGTGAATTTCAAACATCCTCAAAC
ACATGAAACAGCACTGCATTGTGCTGCTGCGTCTCCATATCCTAAAAGAAAGCAAATATGCGAA
CTGCTGCTAAGAAAGGGAGCAAACACCAACGAAAAGACGAAAGAATTCTTGACTCCTCTGCACG
TGGCTTCTGAGAATGCTCACAATGATGTTGTTGAAGTAGTGGTGAAACACGAAGCAAAGGTTAA
TGCTTTGGACAGTCTTGGACAGACATCCTTACACAGAGCTGCACACTGTGGTCATCTGCAGACT
TGCCGCCTTCTCCTGAGCTATGGGTGCGATCCAAACATCATCTCCCTTCAGGGTCTCACTGCCT
TGCAAATGGGAAATGAGAACGTGCAGCAGCTGCTTCAAGAGGGCGTCTCACTAGGTCACTCAGA
GGCAGACAGACAGTTGCTGGAGGCTGCAAAGGCTGGTGATGTAGAAACTGTAAAGAAACTCTGT
ACTGTTCAGAGTGTCAACTGCAGAGACATTGAAGGACGGCAGTCAACCCCACTCCATTTTGCAG
CTGGGTACAACAGAGTGTCTGTGGTAGAGTATCTCCTGCAGCACGGAGCTGACGTACATGCTAA
AGACAAAGGAGGTCTTGTTCCTTTGCACAATGCATGTTCTTACGGACACTATGAAGTTGCAGAA
CTTCTTGTCAAGCATGGAGCAGTAGTTAATGTAGCTGACTTATGGAAGTTCACACCTCTACATG
AAGCTGCAGCAAAAGGAAAATATGAAATATGCAAACTTCTGCTCCAGCATGGTGCAGACCCTAC
AAAGAAAAATAGAGATGGTAATACTCCTCTGGATCTCGTTAAAGATGGAGACACAGATATTCAA
GATCTACTTAGAGGAGATGCAGCCTTACTAGATGCTGCCAAGAAGGGTTGTTTAGCCAGAGTGA
AGAAATTATCTTCACCTGATAATGTAAATTGCCGTGATACCCAAGGTCGACATTCTACACCTTT
GCATTTGGCAGCTGGTTATAATAATTTGGAAGTTGCTGAATATTTGTTGCAACATGGAGCTGAT
GTGAATGCCCAGGACAAAGGAGGACTCATTCCATTACATAATGCAGCATCATATGGACATGTAG
ACGTAGCAGCTTTACTGATAAAGTACAATGCGTGTGTCAATGCCACGGACAAATGGGCTTTCAC
ACCGTTACATGAAGCAGCCCAAAAGGGACGGACACAGCTTTGTGCTTTATTGTTGGCCCATGGA
GCTGATCCTACTCTTAAAAATCAAGAAGGACAAACACCTTTAGACTTAGTTTCAGCAGATGATG
TCAGCGCTCTCTTGACAGCAGCCATGCCCCCCTCTGCTCTGCCTACGTGCTATAAACCTCAAGT
GCTCAGTGGCGTGAGGAGCCCCGGAGCCACTGCAGACGCCCTGTCTTCAGGTCCGTCCAGTCCA
TCCAGCCTTTCTGCAGCCAGCAGCCTCGACAACCTCGCTGGCAGTTTTTCTGAACTGTCTGCAG
TAGTTAGCTCAAGTACAACGGAAGGTGCTACCGGTTTGGAAAGAAAAGAGGATTCAGGAATAGA
TTTTAGTATAACTCAGTTCATAAGGAACCTTGGACTTGAGCATTTAATGGACATATTTGAGCGA
GAACAGATCACCTTGGATGTACTGGTTGAGATGGGCCACAAAGAGCTGAAAGAGATTGGAATCA
GTGCGTATGGACATCGACACAGGCTCATTAAAGGGGTCGAAAGACTGATCTCTGGACAACAAGG
TCTTAATCCATATTTAACTCTAAACAACTCTGGTAGTGGAACAATTCTCATAGATCTGTCTCCT
GATGATAAAGAATTTCAGTCTGTGGAAGAAGAGATGCAAAGTACTGTTCGAGAGCACAGGGATG
GAGGTCACGCAGGCGGCATCTTCAACAGATACAGTATTCTCAAGATTCAGAAGGTTTGTAACAA
GAAATTGTGGGAAAGATATACACACCGGAGAAAAGAAGTTTCTGAAGAAAACCACAACCATGCA
AATGAAAGAATGTTATTTCATGGGTCTCCCTTTGTGAATGCGATAATCCATAAGGGCTTTGATG
AGAGGCACGCCTACATAGGGGGCATGTTTGGAGCTGGGATCTATTTTGCTGAGAACTCTTCCAA
AAGCAATCAGTATGTGTATGGGATTGGAGGTGGCACTGGATGTCCAGTTCACAAAGACAGATCG
TGTTACATTTGTCACAGGCAGCTGCTCTTTTGTCGCGTGACCTTGGGAAAGTCTTTCCTGCAGT
TCAGTGCAATGAAAATGGCGCACTCTCCTCCCGGCCATCACTCAGTCACTGGCCGGCCCAGTGT
GAATGGCCTAGCTTTAGCTGAATATGTTATTTACAGAGGAGAGCAGGCTTACCCTGAATATCTA
ATTACTTACCAGATTGTAAGGCCTGAAGGTATGGGTGATGGCTGAAACCAGTTCTCCCAAACAT
AGTGTCCTGAAGCGCTGACGGCCTCTTAAGTTTCACTCCTTGGCGGGAAAAGATTCATCCTGAC
TACAGGCCTGTGGCAGAAACAAAATGTGAAAGACACCTCATGTTGTGACTTGGTGAAGCTTTAA
CAGTGTACAGTGTTTCCGAGTGTTTCCTGTCTCAGCACTTTAACAGATGCCATTCCAGGTTCAA
CTGGGTCTGTCTGTCCTAAATTATAAACAGTTAACTTGAATCTTTTATACGTCATGCATTGATT
CTAACAAAAATGGTAATCCCTCAACAGAACTCATTTTACTAATCAGTACTGTGTTCTTTAAAAC
ACAGCATTTACACTGAAGACAGTTTCATTTGTAAAATGTAAATAAGAGCTTTTGTACTAGCCCG
GTATTTATTTACATTGCTTTGTACTATAAACTGTTCTAGAGCTGCAGGTTTACAGAGTATTTTC
ATATGTGTTGCTCATCTGTGTTTCATCTGTCGTCACCTGAGTGATCGCTACGTTGGATTCCAGA
GGCTGCTCAGTTGCTAACAGAGTTAGTGGGGAGACATCAACTTAATAAGTTCAATTTGCTGATG
AAAGAATTTCTCTATCAATAGAAATCTTTCACGTAAGAATTTTATAAATACTCTGGGAATTTTA
TTGGTGATGCCTTTGTGTCTACAGGGCACACGTTCCAGAGAGCTCTGGTGTGAAGTGATGGGGG
ACTTGTGGCTAGAGAAGCTTTTCAATGGCCTTAAACTCTGGGTCCTGCTTGAGAGAGGTCTGAG
GTTCTCAACATCAGAGCAGAGCTTCCACCAAGCTTTCAGAATGCTAAGCCCCCACTTCTCAACA
CTTAGTGCTCTGATCATGAATTGTGAGTGGAAGTTACATTTGGTACTGGGGAAGGCAATCATGG
GTATTTCCAATCAGATCTAATTACCTTAAATCTAAAATGGAGGGGTAGGGATAGCAAGTGGGAG
TGGATAGTTTTTTTACTTTCTAAGTTTTCTTGATCTTATGGTTATGTTTATAGCCAGTGTATTT
ATCACGAGTAAACACAACCCAAAATCATAGGTGTGAGTGTATGTGTCTGTGGGTAACCTCTGGA
AAGGGCAAGCCCTGCGCTTCCTACTTCTGTCAAGGCATTCGGCCCAGTTGGAAAAACACTGTCA
CAGGCTTAAGTTCAGTATGGCAGCTGTGGAAGAAGTCACTTTCCATGAAAGGCCATTTTTACTG
TTCTCTAACGTATCTCTAATGTAAGCCTTACACTTACTATCTTATCTTGCATTGCACAGAGATC
TGTCTTACTGCACGGCAGTGCACTCAGAAATCAGAGATTTTTACCCACCTAAGCTTTTGTGAAT
GAGGATGTCCTCTTCACTCTCTTTACCACTTTATCTTTGTTTTATATTTGATTTGGTCTCTTAA
TTACCTGGTCCTTTATACAAACTTGTACATAGAGTTGCTCGAAAGTTAAGCTTAACCATCCTAT
GAGTTAAGAGAATTATATGTCTGGAGTTGTTCCTAAGATGTGAATTGTGGTCAAGGGTTAAGAG
GTCAAATCCTAACCTGGAAATGCTTTTATACAGCTCTCTGCTAACTACAAACATCCTAAAACCA
TTTCTTGAATATAAAAGGAGTATGCCAAATTTTATATAAAATTTTCAGGTTCTGTAAGCTTCTG
GGTTTTATAGTTAAAAGATAATGAAATTAATTGATGGGGTTTATATTTACGTACTTCTAAGGTT
GGCCTATGTTACTCTGTGTATGGATCTGGAATTGTTTTTCATGTAAAATCATGGTCTGGTTATG
AGCTGTGTTACCTCCTAACCCCATTGCTTACGTGTTTCCACTGTGGTCAATACGCTGGCATGGC
AATGTTTATTGGGAGCTGGGAGTTTGGGGGTGTGGTTTAGTGCTTTGCATGAAATACCTTACTT
TATAATGATGAAATTGCTTTTTCTTTTGCCTTGTGATTTTTTTTTTTGAAGTGAAATTTAGTTT
GTGTGTGTGTGGTGATCTGCCCATCGGAGTGTCTCCTTGTATCACATTCCATGCCTCACTTAAC
TCTTAATAAACTGTTTACTTGTTTTATGGGTAGCATGGTAATTCATTGAGATTGCAGTCAATCG
TTATTGCAAGAGAACAGAGTGTAGTTTTGAGTCTGATTGTGACAGGGTGCAACATAAATGTAAA
ATGTTGAATGTTGTGGCCATACTTAACTCAGTTGCTTCCTGATGAAGGTAACATGTGTCTGGGC
GGCTACACCATCTAGTATGACTTTGGTAGTCCTTAAAATTCACCCATGAAATCAGTCTGCTTAA
CTTATAAAGAGAAATATATTTTTGGTTTTTATGTCATAAAAACATTCTTGATAAGTTTCCAAAT
CCCAGTTAGTCATATTTTTTTTCTCTAAAAGGAAAAAAAATTAGTGTATTTTATATTTCCATAT
GCTAATGACCTGTATGTAATTAGTCCTTGGTGTTCCACAAGAAGAGTCTCATCGAAGTCGATAT
AAGCTGCTTTACCCTCCTGCTTCTTTTAAGATGATACTGAAGTGTTTGCTTGCTATTTGCTGAG
CGTGCATGCCCACGTATGATGTGTTCCAATTGTTTGCAGGTTGAGGCAAGAAAACATGCAAATA
AACTTCCCAAACCTCCTAA

hide sequence

RefSeq Acc Id:

XM_039080633 ⟹ XP_038936561

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	243,980,432 - 244,033,629 (+)	NCBI
mRatBN7.2	1	234,567,888 - 234,621,079 (+)	NCBI

RefSeq Acc Id:

XM_039080634 ⟹ XP_038936562

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	243,980,432 - 244,033,629 (+)	NCBI
mRatBN7.2	1	234,567,888 - 234,621,079 (+)	NCBI

RefSeq Acc Id:

XM_063265190 ⟹ XP_063121260

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	243,980,432 - 244,033,629 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001101077	(Get FASTA)	NCBI Sequence Viewer
	XP_038936561	(Get FASTA)	NCBI Sequence Viewer
	XP_038936562	(Get FASTA)	NCBI Sequence Viewer
	XP_063121260	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDM13189	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000068637
	ENSRNOP00000068637.1
	ENSRNOP00000073499
	ENSRNOP00000073499.2
	ENSRNOP00000098656

RefSeq Acc Id:

NP_001101077 ⟸ NM_001107607

- UniProtKB:

A0A0G2JTB0 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MSGRRCAGGGAACSSAVAEAVEPSARELFEACRNGDVERVKRLVTPEKVNSRDTAGRKSTPLHF
AAGFGRKDVVEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLQHGADPNARDNWNYTPL
HEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLADPSAKAVLTGDYKKDELLESARSGNEEK
MMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGH
YEVTELLVKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYGADPTLLNCHNKSAIDLAPTA
QLKERLSYEFKGHSLLQAAREADVTRIKKHLSLEMVNFKHPQTHETALHCAAASPYPKRKQICE
LLLRKGANTNEKTKEFLTPLHVASENAHNDVVEVVVKHEAKVNALDSLGQTSLHRAAHCGHLQT
CRLLLSYGCDPNIISLQGLTALQMGNENVQQLLQEGVSLGHSEADRQLLEAAKAGDVETVKKLC
TVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAE
LLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDLVKDGDTDIQ
DLLRGDAALLDAAKKGCLARVKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGAD
VNAQDKGGLIPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLAHG
ADPTLKNQEGQTPLDLVSADDVSALLTAAMPPSALPTCYKPQVLSGVRSPGATADALSSGPSSP
SSLSAASSLDNLAGSFSELSAVVSSSTTEGATGLERKEDSGIDFSITQFIRNLGLEHLMDIFER
EQITLDVLVEMGHKELKEIGISAYGHRHRLIKGVERLISGQQGLNPYLTLNNSGSGTILIDLSP
DDKEFQSVEEEMQSTVREHRDGGHAGGIFNRYSILKIQKVCNKKLWERYTHRRKEVSEENHNHA
NERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRS
CYICHRQLLFCRVTLGKSFLQFSAMKMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYL
ITYQIVRPEGMGDG

hide sequence

RefSeq Acc Id:	XP_038936562 ⟸ XM_039080634
- Peptide Label:	isoform X2
- UniProtKB:	D3ZRP5 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038936561 ⟸ XM_039080633
- Peptide Label:	isoform X1

Ensembl Acc Id:

ENSRNOP00000068637 ⟸ ENSRNOT00000079808

Ensembl Acc Id:

ENSRNOP00000073499 ⟸ ENSRNOT00000085497

RefSeq Acc Id:	XP_063121260 ⟸ XM_063265190
- Peptide Label:	isoform X3

Ensembl Acc Id:

ENSRNOP00000098656 ⟸ ENSRNOT00000132955

Protein Domains

PARP catalytic SAM

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D3ZRP5-F1-model_v2	AlphaFold	D3ZRP5	1-1166	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1305026	AgrOrtholog
BioCyc Gene	G2FUF-55817	BioCyc
Ensembl Genes	ENSRNOG00000052664	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000079808	ENTREZGENE
	ENSRNOT00000079808.2	UniProtKB/TrEMBL
	ENSRNOT00000085497	ENTREZGENE
	ENSRNOT00000085497.2	UniProtKB/TrEMBL
	ENSRNOT00000132955	ENTREZGENE
Gene3D-CATH	1.10.150.50	UniProtKB/TrEMBL
	1.25.40.20	UniProtKB/TrEMBL
	3.90.228.10	UniProtKB/TrEMBL
	6.20.320.10	UniProtKB/TrEMBL
InterPro	Ankyrin_rpt	UniProtKB/TrEMBL
	Ankyrin_rpt-contain_sf	UniProtKB/TrEMBL
	Poly(ADP-ribose)pol_cat_dom	UniProtKB/TrEMBL
	SAM	UniProtKB/TrEMBL
	SAM_type	UniProtKB/TrEMBL
KEGG Report	rno:309512	UniProtKB/TrEMBL
NCBI Gene	309512	ENTREZGENE
PANTHER	ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39	UniProtKB/TrEMBL
	ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED	UniProtKB/TrEMBL
Pfam	Ank	UniProtKB/TrEMBL
	Ank_2	UniProtKB/TrEMBL
	PARP	UniProtKB/TrEMBL
	SAM_2	UniProtKB/TrEMBL
PhenoGen	Tnks2	PhenoGen
PRINTS	ANKYRIN	UniProtKB/TrEMBL
PROSITE	ANK_REP_REGION	UniProtKB/TrEMBL
	ANK_REPEAT	UniProtKB/TrEMBL
	PARP_CATALYTIC	UniProtKB/TrEMBL
	SAM_DOMAIN	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000052664	RatGTEx
SMART	ANK	UniProtKB/TrEMBL
	SAM	UniProtKB/TrEMBL
Superfamily-SCOP	ADP-ribosylation	UniProtKB/TrEMBL
	ANK	UniProtKB/TrEMBL
	SAM_homology	UniProtKB/TrEMBL
UniProt	A0A0G2JTB0	ENTREZGENE, UniProtKB/TrEMBL
	D3ZRP5	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2021-03-09	Tnks2	tankyrase 2	LOC100910717	tankyrase-2-like	Data merged from RGD:6496922	737654	PROVISIONAL
2016-03-08	Tnks2	tankyrase 2	Tnks2	tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2012-07-05	LOC100910717	tankyrase-2-like			Symbol and Name status set to provisional	70820	PROVISIONAL
2008-04-30	Tnks2	tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2	Tnks2_predicted	tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2 (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-12	Tnks2_predicted	tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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RGD Manual Annotations