Hist1h2bq (histone cluster 1 H2B family member Q) - Rat Genome Database

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Gene: Hist1h2bq (histone cluster 1 H2B family member Q) Rattus norvegicus
Analyze
Symbol: Hist1h2bq
Name: histone cluster 1 H2B family member Q
RGD ID: 1305011
Description: Predicted to enable identical protein binding activity. Predicted to be involved in antimicrobial humoral immune response mediated by antimicrobial peptide and innate immune response in mucosa. Predicted to be located in cytosol; extracellular space; and nucleoplasm. Predicted to be part of nucleosome. Orthologous to several human genes including H2BC10 (H2B clustered histone 10); INTERACTS WITH 17beta-estradiol; 4-tert-Octylphenol; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Hist1h2bh; histone 1, H2bh; histone cluster 1, H2bh; histone cluster 1, H2bq; LOC306945
RGD Orthologs
Human
Bonobo
Dog
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81741,859,955 - 41,869,889 (-)NCBIGRCr8
mRatBN7.21741,432,100 - 41,441,487 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1741,429,164 - 41,442,153 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1741,508,561 - 41,517,933 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01743,112,616 - 43,121,988 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01741,391,323 - 41,400,672 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01743,679,925 - 43,689,311 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1743,679,925 - 43,689,311 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01745,534,129 - 45,542,936 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41748,449,574 - 48,459,325 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11748,452,496 - 48,462,010 (+)NCBI
Celera1741,064,490 - 41,073,875 (-)NCBICelera
Cytogenetic Map17p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:10524764   PMID:12860195   PMID:20458337   PMID:21630459   PMID:23376485   PMID:25954010  


Genomics

Comparative Map Data
Hist1h2bq
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81741,859,955 - 41,869,889 (-)NCBIGRCr8
mRatBN7.21741,432,100 - 41,441,487 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1741,429,164 - 41,442,153 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1741,508,561 - 41,517,933 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01743,112,616 - 43,121,988 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01741,391,323 - 41,400,672 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01743,679,925 - 43,689,311 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1743,679,925 - 43,689,311 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01745,534,129 - 45,542,936 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41748,449,574 - 48,459,325 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11748,452,496 - 48,462,010 (+)NCBI
Celera1741,064,490 - 41,073,875 (-)NCBICelera
Cytogenetic Map17p11NCBI
H2BC7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38626,199,516 - 26,199,988 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl626,199,516 - 26,199,988 (+)EnsemblGRCh38hg38GRCh38
GRCh37626,199,744 - 26,200,216 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36626,307,766 - 26,308,195 (+)NCBINCBI36Build 36hg18NCBI36
Build 34626,307,765 - 26,308,195NCBI
Celera627,429,090 - 27,429,519 (+)NCBICelera
Cytogenetic Map6p22.2NCBI
HuRef626,142,791 - 26,143,220 (+)NCBIHuRef
CHM1_1626,201,968 - 26,202,397 (+)NCBICHM1_1
T2T-CHM13v2.0626,067,982 - 26,068,454 (+)NCBIT2T-CHM13v2.0
LOC100979846
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2540,847,234 - 40,848,917 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1636,848,768 - 36,849,307 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0626,034,782 - 26,036,003 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1626,695,113 - 26,696,330 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl626,695,177 - 26,695,557 (+)Ensemblpanpan1.1panPan2
H2BC8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13524,130,229 - 24,131,736 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3524,131,296 - 24,131,676 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3523,984,338 - 23,985,855 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03524,313,041 - 24,314,561 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3524,178,247 - 24,181,892 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13524,092,926 - 24,094,445 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03524,145,779 - 24,147,302 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03525,610,667 - 25,612,187 (-)NCBIUU_Cfam_GSD_1.0

Variants

.
Variants in Hist1h2bq
41 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:38
Count of miRNA genes:32
Interacting mature miRNAs:35
Transcripts:ENSRNOT00000028779
Prediction methods:Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631497Bp98Blood pressure QTL 983.66arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)174135465160463643Rat
1354581Bp247Blood pressure QTL 2474.5arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)17169599340Rat
1358295Aocep1Aortic cell protein QTL 16.17e-07thoracic aorta cellular protein amount (VT:0010598)aortic cell percentage174099000585990005Rat
1354640Scl32Serum cholesterol level QTL 325.4blood HDL cholesterol amount (VT:0000184)blood high density lipoprotein cholesterol level (CMO:0000052)171578159260781592Rat
2301412Kidm40Kidney mass QTL 400.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)173747984782479847Rat
9590107Sffal7Serum free fatty acids level QTL 74.810.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)172840914773409147Rat
2302377Scl61Serum cholesterol level QTL 614.36blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)172738994653481766Rat
70157Niddm32Non-insulin dependent diabetes mellitus QTL 324.34blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)172245492450909196Rat
724549Niddm56Non-insulin dependent diabetes mellitus QTL 560.03blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)173199078476990784Rat
1598871Memor5Memory QTL 55.3exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)174054004180387013Rat
1354651Lmblg2Limb length QTL 26tibia length (VT:0004357)tibia length (CMO:0000450)17429913069599340Rat
1581512Cm55Cardiac mass QTL 552.80.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172702794956836890Rat
1354628Stl13Serum triglyceride level QTL 133.8blood triglyceride amount (VT:0002644)blood triglyceride level (CMO:0000118)172129303960781592Rat
10054088Scort28Serum corticosterone level QTL 282.040.0102blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17452803849528038Rat
1354630Cm34Cardiac mass QTL 348.7heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)17429913069599340Rat
61394Bp8Blood pressure QTL 82.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)172308056759555013Rat
1559055Bp278Blood pressure QTL 2780.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172365318468653184Rat
10450503Bp386Blood pressure QTL 3860.28arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)173136839162109574Rat
1354638Insul1Insulin level QTL 14.8blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)17429913069599340Rat
2317054Aia12Adjuvant induced arthritis QTL 124.24joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)173828150983281509Rat
2313854Bp343Blood pressure QTL 3433.9life span trait (VT:0005372)age at time of death (CMO:0001193)173199078450909196Rat
1331765Hrtrt15Heart rate QTL 154.094heart pumping trait (VT:2000009)heart rate (CMO:0000002)171533061355836425Rat
8552928Pigfal9Plasma insulin-like growth factor 1 level QTL 99blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)172840914773409147Rat
7394837Memor18Memory QTL 18exploratory behavior trait (VT:0010471)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)171864018263640182Rat
1300148Bp192Blood pressure QTL 1923.47arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)173455084373951021Rat
2317060Aia26Adjuvant induced arthritis QTL 263.22joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)173828150983281509Rat
2303627Vencon8Ventilatory control QTL 80.001respiration trait (VT:0001943)tidal volume (CMO:0000222)17452803849528038Rat
12903980Cm120Cardiac mass QTL 1200.002heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)172365318468653184Rat
4889955Bss93Bone structure and strength QTL 934.4tibia size trait (VT:0100001)tibia cortical bone volume to tibia total bone volume ratio (CMO:0001727)172702794960463643Rat
12903981Am17Aortic mass QTL 170.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)172365318468653184Rat
2303561Bw91Body weight QTL 912body mass (VT:0001259)body weight (CMO:0000012)17886846253868462Rat
12903982Kidm70Kidney mass QTL 700.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)172365318470974005Rat
2324621Coatc5Coat color QTL 5coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)173136839173951021Rat
12903978Cm118Cardiac mass QTL 1180.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)172365318468653184Rat
1354619Bp242Blood pressure QTL 2426.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)172459934069599340Rat
12903979Cm119Cardiac mass QTL 1190.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172365318468653184Rat
1354596Bw32Body weight QTL 324.5body mass (VT:0001259)body weight (CMO:0000012)17429913060781592Rat
1354662Rf49Renal function QTL 492.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)17169599340Rat
1354663Bvd5Brain ventricular dilatation QTL 53.510.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)173199078481292925Rat
7488966Bp370Blood pressure QTL 3700.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172365318457246843Rat
1354658Spl8Serum phospholipid level QTL 83.8blood VLDL phospholipid amount (VT:0010507)blood very low density lipoprotein phospholipid level (CMO:0001571)17160781592Rat
1354659Scl68Serum cholesterol level QTL 683.9blood VLDL cholesterol amount (VT:0005144)blood very low density lipoprotein cholesterol level (CMO:0000648)171578159260781592Rat
724528Uae4Urinary albumin excretion QTL 44.90.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)173583708569599340Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 41 57 41 18 41 8 10 66 35 34 11 8
Low 1 2 1 1 8 7
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000028779   ⟹   ENSRNOP00000028779
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1743,679,925 - 43,689,311 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000116857   ⟹   ENSRNOP00000083018
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1741,429,164 - 41,442,153 (-)Ensembl
RefSeq Acc Id: NM_001107352   ⟹   NP_001100822
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81741,859,955 - 41,869,341 (-)NCBI
mRatBN7.21741,432,100 - 41,441,487 (-)NCBI
Rnor_6.01743,679,925 - 43,689,311 (-)NCBI
Rnor_5.01745,534,129 - 45,542,936 (-)NCBI
RGSC_v3.41748,449,574 - 48,459,325 (+)RGD
Celera1741,064,490 - 41,073,875 (-)RGD
Sequence:
RefSeq Acc Id: XM_063276432   ⟹   XP_063132502
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81741,860,107 - 41,869,889 (-)NCBI
RefSeq Acc Id: XM_063276433   ⟹   XP_063132503
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81741,860,107 - 41,869,866 (-)NCBI
RefSeq Acc Id: XR_010058867
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81741,864,807 - 41,869,349 (-)NCBI
RefSeq Acc Id: NP_001100822   ⟸   NM_001107352
- UniProtKB: G3V8B3 (UniProtKB/TrEMBL),   G3V9C7 (UniProtKB/TrEMBL),   A6KLP6 (UniProtKB/TrEMBL),   A0A8I6AGQ8 (UniProtKB/TrEMBL),   A6KNB9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000028779   ⟸   ENSRNOT00000028779
RefSeq Acc Id: ENSRNOP00000083018   ⟸   ENSRNOT00000116857
RefSeq Acc Id: XP_063132502   ⟸   XM_063276432
- Peptide Label: isoform X1
- UniProtKB: A0A8I6AGQ8 (UniProtKB/TrEMBL),   A6KNB9 (UniProtKB/TrEMBL),   A6KLP6 (UniProtKB/TrEMBL),   G3V8B3 (UniProtKB/TrEMBL),   G3V9C7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063132503   ⟸   XM_063276433
- Peptide Label: isoform X1
- UniProtKB: A0A8I6AGQ8 (UniProtKB/TrEMBL),   A6KNB9 (UniProtKB/TrEMBL),   A6KLP6 (UniProtKB/TrEMBL),   G3V8B3 (UniProtKB/TrEMBL),   G3V9C7 (UniProtKB/TrEMBL)
Protein Domains
Histone H2A/H2B/H3

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-G3V8B3-F1-model_v2 AlphaFold G3V8B3 1-126 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700463
Promoter ID:EPDNEW_R10987
Type:single initiation site
Name:LOC100910200_1
Description:histone H2B type 1-C/E/G-like
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01743,689,256 - 43,689,316EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1305011 AgrOrtholog
BioCyc Gene G2FUF-9376 BioCyc
Ensembl Genes ENSRNOG00000021198 Ensembl
  ENSRNOG00000064011 UniProtKB/TrEMBL
  ENSRNOG00000069578 Ensembl, UniProtKB/TrEMBL
  ENSRNOG00000070362 UniProtKB/TrEMBL
  ENSRNOG00000070916 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000089643.2 UniProtKB/TrEMBL
  ENSRNOT00000097860.1 UniProtKB/TrEMBL
  ENSRNOT00000101742.1 UniProtKB/TrEMBL
  ENSRNOT00000116857.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.20.10 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7121683 IMAGE-MGC_LOAD
InterPro Histone-fold UniProtKB/TrEMBL
  Histone_H2A/H2B/H3 UniProtKB/TrEMBL
  Histone_H2B UniProtKB/TrEMBL
KEGG Report rno:100359692 UniProtKB/TrEMBL
  rno:100910200 UniProtKB/TrEMBL
  rno:306945 UniProtKB/TrEMBL
MGC_CLONE MGC:95013 IMAGE-MGC_LOAD
NCBI Gene 306945 ENTREZGENE
PANTHER HISTONE H2B TYPE 1-J UniProtKB/TrEMBL
  PTHR23428 UniProtKB/TrEMBL
Pfam Histone UniProtKB/TrEMBL
PhenoGen Hist1h2bq PhenoGen
PRINTS HISTONEH2B UniProtKB/TrEMBL
PROSITE HISTONE_H2B UniProtKB/TrEMBL
RatGTEx ENSRNOG00000021198 RatGTEx
  ENSRNOG00000064011 RatGTEx
  ENSRNOG00000069578 RatGTEx
  ENSRNOG00000070362 RatGTEx
  ENSRNOG00000070916 RatGTEx
SMART H2B UniProtKB/TrEMBL
Superfamily-SCOP SSF47113 UniProtKB/TrEMBL
UniProt A0A8I6AGQ8 ENTREZGENE, UniProtKB/TrEMBL
  A6KLP6 ENTREZGENE, UniProtKB/TrEMBL
  A6KNB9 ENTREZGENE, UniProtKB/TrEMBL
  G3V8B3 ENTREZGENE
  G3V9C7 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary G3V8B3 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-05-23 Hist1h2bq  histone cluster 1 H2B family member Q  Hist1h2bq  histone cluster 1, H2bq  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-07-17 Hist1h2bq  histone cluster 1, H2bq  Hist1h2bh  histone cluster 1, H2bh  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-07 Hist1h2bh  histone cluster 1, H2bh    histone 1, H2bh  Name updated 1299863 APPROVED
2005-12-06 Hist1h2bh  histone 1, H2bh  Hist1h2bh_predicted  histone 1, H2bh (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Hist1h2bh_predicted  histone 1, H2bh (predicted)      Symbol and Name status set to approved 70820 APPROVED