Usp8 (ubiquitin specific peptidase 8) - Rat Genome Database

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Gene: Usp8 (ubiquitin specific peptidase 8) Rattus norvegicus
Analyze
Symbol: Usp8
Name: ubiquitin specific peptidase 8
RGD ID: 1304979
Description: Predicted to enable K48-linked deubiquitinase activity; K63-linked deubiquitinase activity; and cysteine-type deubiquitinase activity. Involved in cellular response to dexamethasone stimulus; cellular response to nerve growth factor stimulus; and regulation of protein catabolic process at postsynapse, modulating synaptic transmission. Located in early endosome. Is active in glutamatergic synapse and postsynaptic density. Human ortholog(s) of this gene implicated in ACTH-secreting pituitary adenoma. Orthologous to human USP8 (ubiquitin specific peptidase 8); PARTICIPATES IN mitochondrial autophagy pathway; endocytosis pathway; INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 2,4,6-trinitrobenzenesulfonic acid.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC296121; ubiquitin carboxyl-terminal hydrolase 8; ubiquitin specific protease 8
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83134,413,832 - 134,463,040 (+)NCBIGRCr8
mRatBN7.23113,962,136 - 114,009,683 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3113,962,164 - 114,009,666 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3117,845,850 - 117,893,311 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03126,441,377 - 126,488,837 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03124,101,758 - 124,149,218 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03119,173,818 - 119,222,499 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3119,173,818 - 119,222,484 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03125,699,400 - 125,747,055 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43114,237,065 - 114,284,543 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13114,103,490 - 114,189,451 (+)NCBI
Celera3112,804,623 - 112,852,132 (+)NCBICelera
Cytogenetic Map3q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
acrosomal membrane  (ISO)
cytoplasm  (ISO)
cytosol  (IBA,ISO)
dendritic spine  (IBA)
early endosome  (IDA,ISO)
endosome membrane  (ISO)
glutamatergic synapse  (IDA,IEP,IMP)
midbody  (IBA,ISO)
postsynaptic density  (IBA,IDA,IEP)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. The deubiquitinating enzyme UBPy/USP8 interacts with TrkA and inhibits neuronal differentiation in PC12 cells. Ceriani M, etal., Exp Cell Res. 2015 Apr 10;333(1):49-59. doi: 10.1016/j.yexcr.2015.01.019. Epub 2015 Feb 4.
2. The three 'P's of mitophagy: PARKIN, PINK1, and post-translational modifications. Durcan TM and Fon EA, Genes Dev. 2015 May 15;29(10):989-99. doi: 10.1101/gad.262758.115.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Comprehensive gene review and curation RGD comprehensive gene curation
10. Synaptic strength is bidirectionally controlled by opposing activity-dependent regulation of Nedd4-1 and USP8. Scudder SL, etal., J Neurosci. 2014 Dec 10;34(50):16637-49. doi: 10.1523/JNEUROSCI.2452-14.2014.
11. Dexamethasone regulates expression of BRUCE/Apollon and the proliferation of neural progenitor cells. Sippel M, etal., FEBS Lett. 2009 Jul 7;583(13):2213-7. doi: 10.1016/j.febslet.2009.06.018. Epub 2009 Jun 13.
Additional References at PubMed
PMID:11500497   PMID:15314180   PMID:15342353   PMID:16120644   PMID:16520378   PMID:16771824   PMID:18388320   PMID:20495530   PMID:25468996   PMID:27302062   PMID:29735556   PMID:31904090  


Genomics

Comparative Map Data
Usp8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83134,413,832 - 134,463,040 (+)NCBIGRCr8
mRatBN7.23113,962,136 - 114,009,683 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3113,962,164 - 114,009,666 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3117,845,850 - 117,893,311 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03126,441,377 - 126,488,837 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03124,101,758 - 124,149,218 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03119,173,818 - 119,222,499 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3119,173,818 - 119,222,484 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03125,699,400 - 125,747,055 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43114,237,065 - 114,284,543 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13114,103,490 - 114,189,451 (+)NCBI
Celera3112,804,623 - 112,852,132 (+)NCBICelera
Cytogenetic Map3q36NCBI
USP8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381550,424,405 - 50,514,421 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1550,424,380 - 50,514,421 (+)EnsemblGRCh38hg38GRCh38
GRCh371550,716,602 - 50,806,618 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361548,503,871 - 48,579,265 (+)NCBINCBI36Build 36hg18NCBI36
Build 341548,503,870 - 48,579,263NCBI
Celera1527,609,144 - 27,685,855 (+)NCBICelera
Cytogenetic Map15q21.2NCBI
HuRef1527,547,372 - 27,623,683 (+)NCBIHuRef
CHM1_11550,834,671 - 50,911,286 (+)NCBICHM1_1
T2T-CHM13v2.01548,232,513 - 48,322,500 (+)NCBIT2T-CHM13v2.0
Usp8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392126,549,280 - 126,601,234 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2126,549,248 - 126,601,217 (+)EnsemblGRCm39 Ensembl
GRCm382126,707,201 - 126,759,314 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2126,707,328 - 126,759,297 (+)EnsemblGRCm38mm10GRCm38
MGSCv372126,533,099 - 126,585,033 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362126,398,804 - 126,450,738 (+)NCBIMGSCv36mm8
Celera2127,946,958 - 127,999,152 (+)NCBICelera
Cytogenetic Map2F1NCBI
cM Map261.76NCBI
Usp8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554093,840,007 - 3,891,284 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554093,839,308 - 3,903,595 (-)NCBIChiLan1.0ChiLan1.0
USP8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21639,669,333 - 39,746,278 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11543,850,502 - 43,939,848 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01529,374,945 - 29,451,235 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11547,699,282 - 47,790,624 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1547,713,997 - 47,790,624 (+)Ensemblpanpan1.1panPan2
USP8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13016,341,970 - 16,408,246 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3016,342,009 - 16,408,012 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3016,268,046 - 16,334,339 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03016,485,884 - 16,552,179 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3016,485,928 - 16,552,172 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13016,408,382 - 16,474,666 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03016,525,850 - 16,592,342 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03016,632,281 - 16,698,545 (+)NCBIUU_Cfam_GSD_1.0
Usp8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864094,615,145 - 94,673,337 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647112,463,120 - 12,520,674 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647112,463,189 - 12,524,148 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
USP8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1121,306,032 - 121,413,223 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11121,306,031 - 121,376,154 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21134,747,956 - 134,815,830 (-)NCBISscrofa10.2Sscrofa10.2susScr3
USP8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12632,829,627 - 32,906,493 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2632,829,523 - 32,866,073 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666048108,247,584 - 108,324,662 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Usp8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247319,613,227 - 9,679,404 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247319,615,963 - 9,678,969 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Usp8
347 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:410
Count of miRNA genes:215
Interacting mature miRNAs:253
Transcripts:ENSRNOT00000015124
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2312673Scl63Serum cholesterol level QTL 630.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)398535255168026850Rat
2301414Kidm37Kidney mass QTL 370.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)370653097121056321Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)398535386161695835Rat
1582238Bw68Body weight QTL 683.20.0064body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
1582239Epfw1Epididymal fat weight QTL 14.50.0006epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)353184593115665732Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)347233211147415807Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)338192233133483320Rat
1582216Bw65Body weight QTL 656.3body mass (VT:0001259)body weight (CMO:0000012)3102200529115665732Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)329463235118376539Rat
1582218Bw74Body weight QTL 743.90.0021body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
1582219Bw63Body weight QTL 633.80.001body mass (VT:0001259)body weight (CMO:0000012)396127817115665732Rat
1582221Kidm30Kidney mass QTL 303.50.0008kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)364655305115665732Rat
1581568Rf53Renal function QTL 53urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)356395968161299569Rat
1582210Bw71Body weight QTL 713.30.0012body mass (VT:0001259)body weight (CMO:0000012)364655305115665732Rat
1578754Stresp16Stress response QTL 1640.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)3112681431157681431Rat
7387306Bw124Body weight QTL 1243.20.0003body mass (VT:0001259)body weight (CMO:0000012)384091273129091273Rat
1300111Rf12Renal function QTL 123.78renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)361017749121056321Rat
724523Tsu1Thymus enlargement suppressive QTL 13.84thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)350437504115638231Rat
1600376Arunc5Aerobic running capacity QTL 50.21exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)373376539118376539Rat
8694437Bw167Body weight QTL 16722.460.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)391797474136797474Rat
2302273Gluco35Glucose level QTL 355.30.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)380800231114297550Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)359242096157323038Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
1581503Cm58Cardiac mass QTL 582.70.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)343827364121056321Rat
1354611Despr2Despair related QTL 23.030.0028locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)397084464142084464Rat
631649Bp123Blood pressure QTL 1233.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)389772419134772419Rat
631841Niddm39Non-insulin dependent diabetes mellitus QTL 393.36blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)394856903159898684Rat
619618Rf3Renal disease susceptibility QTL 36.50.001urine albumin amount (VT:0002871)urine albumin excretion rate to body weight ratio (CMO:0001270)3107693393152693393Rat
12879848Bw181Body weght QTL 1810.015body mass (VT:0001259)body weight (CMO:0000012)370348525121056321Rat
2312659Slep7Serum leptin concentration QTL 70.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)398535255168026850Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)341874578155617519Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)341874578155617519Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
1581546Pur13Proteinuria QTL 132.930.0335urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)378196190146592722Rat
631665Bw8Body weight QTL 85.5body mass (VT:0001259)body weight (CMO:0000012)350437042119183768Rat
1331758Bp207Blood pressure QTL 2072.848arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3112287552135181505Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
2312670Bw94Body weight QTL 940.01inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)398535255168026850Rat
2293087Iddm27Insulin dependent diabetes mellitus QTL 272.68blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)397551417147415807Rat
724532Cm17Cardiac mass QTL 172heart mass (VT:0007028)calculated heart weight (CMO:0000073)395735366140735366Rat

Markers in Region
RH139756  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23113,962,427 - 113,962,613 (+)MAPPERmRatBN7.2
Rnor_6.03119,174,087 - 119,174,272NCBIRnor6.0
Rnor_5.03125,699,669 - 125,699,854UniSTSRnor5.0
RGSC_v3.43114,237,334 - 114,237,519UniSTSRGSC3.4
Celera3112,804,892 - 112,805,077UniSTS
RH 3.4 Map3988.5UniSTS
Cytogenetic Map3q36UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000015124   ⟹   ENSRNOP00000015124
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3113,962,164 - 114,009,665 (+)Ensembl
Rnor_6.0 Ensembl3119,173,818 - 119,222,484 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000120063   ⟹   ENSRNOP00000086524
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3113,962,164 - 114,009,666 (+)Ensembl
RefSeq Acc Id: NM_001106502   ⟹   NP_001099972
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83134,415,526 - 134,463,025 (+)NCBI
mRatBN7.23113,962,159 - 114,009,661 (+)NCBI
Rnor_6.03119,173,818 - 119,222,484 (+)NCBI
Rnor_5.03125,699,400 - 125,747,055 (+)NCBI
RGSC_v3.43114,237,065 - 114,284,543 (+)RGD
Celera3112,804,623 - 112,852,132 (+)RGD
Sequence:
RefSeq Acc Id: XM_006234916   ⟹   XP_006234978
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83134,413,832 - 134,463,040 (+)NCBI
mRatBN7.23113,962,140 - 114,009,683 (+)NCBI
Rnor_6.03119,173,823 - 119,222,499 (+)NCBI
Rnor_5.03125,699,400 - 125,747,055 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063283328   ⟹   XP_063139398
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83134,413,832 - 134,456,180 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001099972 (Get FASTA)   NCBI Sequence Viewer  
  NP_001417030 (Get FASTA)   NCBI Sequence Viewer  
  XP_006234978 (Get FASTA)   NCBI Sequence Viewer  
  XP_063139398 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL80091 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000015124.6
  ENSRNOP00000086524.1
RefSeq Acc Id: NP_001099972   ⟸   NM_001106502
- UniProtKB: D3ZN39 (UniProtKB/TrEMBL),   A6HPZ0 (UniProtKB/TrEMBL),   A0A8I6A1E0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006234978   ⟸   XM_006234916
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000015124   ⟸   ENSRNOT00000015124
Ensembl Acc Id: ENSRNOP00000086524   ⟸   ENSRNOT00000120063
RefSeq Acc Id: XP_063139398   ⟸   XM_063283328
- Peptide Label: isoform X2
Protein Domains
Rhodanese   USP

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZN39-F1-model_v2 AlphaFold D3ZN39 1-1081 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692391
Promoter ID:EPDNEW_R2916
Type:initiation region
Name:Usp8_1
Description:ubiquitin specific peptidase 8
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03119,173,852 - 119,173,912EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1304979 AgrOrtholog
BioCyc Gene G2FUF-48018 BioCyc
Ensembl Genes ENSRNOG00000010729 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000015124.7 UniProtKB/TrEMBL
  ENSRNOT00000120063.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.250.10 UniProtKB/TrEMBL
  Cysteine proteinases UniProtKB/TrEMBL
  Phosphotransferase system, lactose/cellobiose-type IIA subunit UniProtKB/TrEMBL
InterPro DUF1873 UniProtKB/TrEMBL
  Papain_like_cys_pep_sf UniProtKB/TrEMBL
  Pept_C19ubi-hydrolase_C_CS UniProtKB/TrEMBL
  Peptidase_C19 UniProtKB/TrEMBL
  Rhodanese-like_dom UniProtKB/TrEMBL
  Rhodanese-like_dom_sf UniProtKB/TrEMBL
  Ub_carboxyl-term_hydrolase UniProtKB/TrEMBL
  UCH/PAN2 UniProtKB/TrEMBL
  WW_USP8 UniProtKB/TrEMBL
KEGG Report rno:296121 UniProtKB/TrEMBL
NCBI Gene 296121 ENTREZGENE
PANTHER UBIQUITIN CARBOXYL-TERMINAL HYDROLASE UniProtKB/TrEMBL
  UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 8 UniProtKB/TrEMBL
Pfam DUF1873 UniProtKB/TrEMBL
  Rhodanese UniProtKB/TrEMBL
  UCH UniProtKB/TrEMBL
  WW_USP8 UniProtKB/TrEMBL
PhenoGen Usp8 PhenoGen
PROSITE RHODANESE_3 UniProtKB/TrEMBL
  UCH_2_1 UniProtKB/TrEMBL
  UCH_2_2 UniProtKB/TrEMBL
  UCH_2_3 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000010729 RatGTEx
SMART RHOD UniProtKB/TrEMBL
Superfamily-SCOP Rhodanese-like UniProtKB/TrEMBL
  SSF54001 UniProtKB/TrEMBL
  USP8 N-terminal domain-like UniProtKB/TrEMBL
UniProt A0A8I6A1E0 ENTREZGENE, UniProtKB/TrEMBL
  A6HPZ0 ENTREZGENE, UniProtKB/TrEMBL
  D3ZN39 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-04 Usp8  ubiquitin specific peptidase 8  Usp8_predicted  ubiquitin specific protease 8 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-12 Usp8_predicted  ubiquitin specific protease 8 (predicted)      Symbol and Name status set to approved 70820 APPROVED