Rhoc (ras homolog family member C) - Rat Genome Database

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Gene: Rhoc (ras homolog family member C) Rattus norvegicus
Analyze
Symbol: Rhoc
Name: ras homolog family member C
RGD ID: 1304965
Description: Predicted to enable GTP binding activity; GTPase activity; and protein kinase binding activity. Predicted to be involved in several processes, including positive regulation of canonical NF-kappaB signal transduction; positive regulation of cellular component biogenesis; and skeletal muscle satellite cell migration. Located in cytosol and membrane. Orthologous to human RHOC (ras homolog family member C); INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 2,2',4,4'-Tetrabromodiphenyl ether.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC295342; ras homolog gene family, member C; rho-related GTP-binding protein RhoC
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82194,975,586 - 194,981,637 (+)NCBIGRCr8
GRCr8 Ensembl2194,975,242 - 194,983,745 (+)EnsemblGRCr8 Ensembl
mRatBN7.22192,287,065 - 192,293,292 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2192,287,130 - 192,295,306 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2199,881,601 - 199,887,650 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02197,753,887 - 197,759,938 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02192,570,831 - 192,576,882 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02207,271,692 - 207,278,010 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2207,271,853 - 207,279,314 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02226,690,856 - 226,697,174 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42200,048,056 - 200,054,107 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera2184,753,781 - 184,759,832 (+)NCBICelera
RGSC_v3.12200,010,698 - 200,017,126 (+)NCBI
Cytogenetic Map2q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (EXP)
1-octadec-9-enoylglycero-3-phosphate  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,3,3',4,4',5,5'-Heptachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2-amino-2-deoxy-D-glucopyranose  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrolein  (ISO)
acrylamide  (EXP)
actinomycin D  (ISO)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucosamine  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
arsenous acid  (ISO)
atorvastatin calcium  (ISO)
atrazine  (ISO)
azathioprine  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
Benzo[k]fluoranthene  (ISO)
beta-D-glucosamine  (ISO)
beta-lapachone  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
camptothecin  (ISO)
carbon nanotube  (ISO)
celecoxib  (ISO)
chlordecone  (ISO)
chloropicrin  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
chrysene  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
copper(II) sulfate  (ISO)
cycloheximide  (ISO)
cyclosporin A  (ISO)
cyproconazole  (ISO)
cytarabine  (ISO)
decabromodiphenyl ether  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP)
dinophysistoxin 1  (ISO)
dioxygen  (ISO)
diuron  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
farnesol  (ISO)
fenamidone  (ISO)
fenthion  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
fumonisin B1  (ISO)
furan  (EXP)
geranylgeraniol  (ISO)
Indeno[1,2,3-cd]pyrene  (ISO)
indometacin  (ISO)
inulin  (ISO)
ivermectin  (ISO)
L-methionine  (ISO)
lead(0)  (ISO)
menadione  (ISO)
methimazole  (EXP)
microcystin-LR  (ISO)
Monobutylphthalate  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-nitrosodiethylamine  (ISO)
naphthalene  (ISO)
nickel sulfate  (ISO)
Nutlin-3  (ISO)
okadaic acid  (ISO)
orphenadrine  (EXP)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenanthrene  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
simvastatin  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
succimer  (ISO)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
Tanshinone I  (ISO)
terbinafine  (ISO)
tetrachloromethane  (ISO)
tetraphene  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
triadimefon  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vinclozolin  (EXP)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cleavage furrow  (IEA,ISO)
cytosol  (IBA,IDA)
membrane  (IDA,IEA)
nucleus  (ISO)
plasma membrane  (IBA,IEA,ISO)
stereocilium  (ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Rho GTPases in human breast tumours: expression and mutation analyses and correlation with clinical parameters. Fritz G, etal., Br J Cancer. 2002 Sep 9;87(6):635-44.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Up-regulation of small GTPases, RhoA and RhoC, is associated with tumor progression in ovarian carcinoma. Horiuchi A, etal., Lab Invest. 2003 Jun;83(6):861-70.
5. Extra-nuclear activation of progesterone receptor in regulating arterial smooth muscle cell migration. Hsu SP, etal., Atherosclerosis. 2011 Jul;217(1):83-9. doi: 10.1016/j.atherosclerosis.2011.02.051. Epub 2011 Mar 10.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. GOA pipeline RGD automated data pipeline
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:12761501   PMID:15093731   PMID:16236794   PMID:16750170   PMID:19056867   PMID:19199708   PMID:19887681   PMID:20232393   PMID:20974804   PMID:21474314   PMID:23376485  
PMID:27269051  


Genomics

Comparative Map Data
Rhoc
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82194,975,586 - 194,981,637 (+)NCBIGRCr8
GRCr8 Ensembl2194,975,242 - 194,983,745 (+)EnsemblGRCr8 Ensembl
mRatBN7.22192,287,065 - 192,293,292 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2192,287,130 - 192,295,306 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2199,881,601 - 199,887,650 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02197,753,887 - 197,759,938 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02192,570,831 - 192,576,882 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02207,271,692 - 207,278,010 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2207,271,853 - 207,279,314 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02226,690,856 - 226,697,174 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42200,048,056 - 200,054,107 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera2184,753,781 - 184,759,832 (+)NCBICelera
RGSC_v3.12200,010,698 - 200,017,126 (+)NCBI
Cytogenetic Map2q34NCBI
RHOC
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381112,701,131 - 112,707,408 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1112,701,127 - 112,707,434 (-)EnsemblGRCh38hg38GRCh38
GRCh371113,243,753 - 113,250,030 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361113,045,272 - 113,051,548 (-)NCBINCBI36Build 36hg18NCBI36
Build 341112,955,796 - 112,961,762NCBI
Celera1111,474,221 - 111,480,469 (-)NCBICelera
Cytogenetic Map1p13.2NCBI
HuRef1111,102,116 - 111,108,421 (-)NCBIHuRef
CHM1_11113,358,995 - 113,365,227 (-)NCBICHM1_1
T2T-CHM13v2.01112,713,708 - 112,719,957 (-)NCBIT2T-CHM13v2.0
Rhoc
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393104,696,350 - 104,701,775 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3104,695,691 - 104,701,775 (+)EnsemblGRCm39 Ensembl
GRCm383104,789,034 - 104,794,459 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3104,788,375 - 104,794,459 (+)EnsemblGRCm38mm10GRCm38
MGSCv373104,591,952 - 104,597,377 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363104,917,108 - 104,922,515 (+)NCBIMGSCv36mm8
Celera3106,984,393 - 106,989,818 (+)NCBICelera
Cytogenetic Map3F2.2NCBI
cM Map345.86NCBI
Rhoc
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543516,115,095 - 16,117,869 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543516,115,095 - 16,117,736 (-)NCBIChiLan1.0ChiLan1.0
RHOC
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21114,328,960 - 114,335,138 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11113,477,089 - 113,483,288 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01115,353,868 - 115,360,036 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11124,993,063 - 124,998,968 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1124,993,063 - 125,001,708 (+)Ensemblpanpan1.1panPan2
RHOC
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11762,868,373 - 62,872,322 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1762,379,903 - 62,385,777 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01764,039,576 - 64,045,450 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1764,039,594 - 64,046,097 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11762,774,224 - 62,780,085 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01762,832,308 - 62,838,186 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01763,592,021 - 63,597,895 (+)NCBIUU_Cfam_GSD_1.0
Rhoc
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505816,219,481 - 16,222,601 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049366901,255,126 - 1,258,288 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RHOC
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl4107,731,539 - 107,737,705 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.14107,731,713 - 107,737,705 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24117,848,790 - 117,854,768 (-)NCBISscrofa10.2Sscrofa10.2susScr3
RHOC
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12020,932,533 - 20,938,703 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2020,936,018 - 20,938,284 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603823,749,488 - 23,755,659 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rhoc
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247728,479,015 - 8,486,171 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247728,481,826 - 8,487,530 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Rhoc
21 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:103
Count of miRNA genes:78
Interacting mature miRNAs:97
Transcripts:ENSRNOT00000017254
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358356Srcrt1Stress Responsive Cort QTL13.66blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)2163997722225110681Rat
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2169358774214358774Rat
1331734Bp204Blood pressure QTL 2043.61192arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2170656145239614549Rat
631566Bp90Blood pressure QTL 900.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2149957381221199885Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845370229470703Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)283465462229820014Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)220695736231474293Rat
1298076Bp166Blood pressure QTL 1660.0009arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2138595962205135428Rat
1581576Pur7Proteinuria QTL 70.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)280396178220931218Rat
152025245Scl81Serum cholesterol level QTL 813.49blood cholesterol amount (VT:0000180)2124537199209621565Rat
1581578Cm49Cardiac mass QTL 494.90.01heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2145807215220931416Rat
61458Bp10Blood pressure QTL 103.42arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2191709311217961898Rat
631198Cm22Cardiac mass QTL 224.30.0008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)278269809208420281Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2122597372215234002Rat
12879836Kidm61Kidney mass QTL 610.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2154723085199723085Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)280396178220931218Rat
12879837Am2Aortic mass QTL 20.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)2154723085199723085Rat
10043139Iddm55Insulin dependent diabetes mellitus QTL 553.10.0001blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)2150313808195313808Rat
12879838Cm86Cardiac mass QTL 860.002heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2154723085199723085Rat
1302793Bw16Body weight QTL 1650.0001body mass (VT:0001259)body weight (CMO:0000012)2159440891205135267Rat
12879839Cm85Cardiac mass QTL 850.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)2154723085199723085Rat
1549833Bp257Blood pressure QTL 2570.003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2170652929215652929Rat
1358900Bw48Body weight QTL 484.88body mass (VT:0001259)body weight (CMO:0000012)2159440891220931218Rat
4889834Pur24Proteinuria QTL 245.80.014urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)2171994826205135428Rat
1359031Bp275Blood pressure QTL 275arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2188565047233565047Rat
1581499Esta2Estrogen-induced thymic atrophy QTL 2thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2192287802229609668Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)24265106205135428Rat
12879840Bw179Body weight QTL 1790.005body mass (VT:0001259)body weight (CMO:0000012)2154723085199723085Rat
9589044Scfw1Subcutaneous fat weight QTL 15.80.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)2184856304229856304Rat
8694435Bw166Body weight QTL 16614.080.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)2184856304229856304Rat
1359032Hrtrt18Heart rate QTL 18heart pumping trait (VT:2000009)heart rate (CMO:0000002)2159440760195313808Rat
2301966Bp322Blood pressure QTL 3223.58arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2144882354205135428Rat
1298083Bp158Blood pressure QTL 1582.62arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2191709311217961898Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845182205135428Rat
1357991Ael2Aortic elastin QTL 24.20.000071aorta elastin amount (VT:0003905)aortic elastin2169227906214227906Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)283400752223709938Rat
1331745Bp203Blood pressure QTL 2034.377arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2192287802221089121Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
8694194Abfw1Abdominal fat weight QTL 111.70.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)2184856304229856304Rat
61366Iddm3Insulin dependent diabetes mellitus QTL 34.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2192287802237287802Rat
1578671Bmd10Bone mineral density QTL 105.4femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)2175931416220931416Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2151869660251712708Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)280396034220931416Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)278269809205135428Rat
2300189Bmd48Bone mineral density QTL 485.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)2182024327227024327Rat
8662843Vetf9Vascular elastic tissue fragility QTL 92.05thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2159440760228950743Rat
2301408Kidm36Kidney mass QTL 360.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2184482291229482291Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2143344967251712708Rat
71113Cari2Carrageenan-induced inflammation QTL 22.70.009hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)2143746578205135428Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2143344967251712708Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2114384617215381366Rat
1598805Memor8Memory QTL 83exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)2150096616195096616Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
724568Uae13Urinary albumin excretion QTL 134.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)2145306936212705578Rat
7488929Bp366Blood pressure QTL 3660.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2187663373195783351Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
1300165Rf9Renal function QTL 93.28kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)2113746222205135428Rat
738013Alc15Alcohol consumption QTL 154.10.00022consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)2186850607231850607Rat
61398Bp50Blood pressure QTL 504.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2192287802237287802Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2114384617215381366Rat
1641925Alcrsp2Alcohol response QTL 2response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2151869660223841096Rat
1354609Niddm62Non-insulin dependent diabetes mellitus QTL 624.720.000006insulin secretion trait (VT:0003564)plasma insulin level (CMO:0000342)2117415288205135428Rat
1598833Bp295Blood pressure QTL 2953.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150096616195096616Rat
61417Cia10Collagen induced arthritis QTL 103.4joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)2182635347227635347Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)283465462225110681Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)247856345205135428Rat
631522Bp74Blood pressure QTL 740.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2175008837220008837Rat
8694383Bw158Body weight QTL 1587.690.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)2184856304229856304Rat
7488927Bp365Blood pressure QTL 3650.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2165453811210453811Rat
7488925Bp364Blood pressure QTL 3640.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2163253030208253030Rat
2306901Bp337Blood pressure QTL 3370.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2166372086229820014Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)276328396209350714Rat

Markers in Region
RH141102  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22192,292,458 - 192,292,661 (+)MAPPERmRatBN7.2
Rnor_6.02207,277,177 - 207,277,379NCBIRnor6.0
Rnor_5.02226,696,341 - 226,696,543UniSTSRnor5.0
RGSC_v3.42200,053,274 - 200,053,476UniSTSRGSC3.4
Celera2184,758,999 - 184,759,201UniSTS
RH 3.4 Map21349.5UniSTS
Cytogenetic Map2q34UniSTS
AA850795  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22192,292,095 - 192,292,266 (+)MAPPERmRatBN7.2
Rnor_6.02207,276,814 - 207,276,984NCBIRnor6.0
Rnor_5.02226,695,978 - 226,696,148UniSTSRnor5.0
RGSC_v3.42200,052,911 - 200,053,081UniSTSRGSC3.4
Celera2184,758,636 - 184,758,806UniSTS
RH 3.4 Map21351.4UniSTS
Cytogenetic Map2q34UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
9 11 49 113 91 90 59 25 59 6 218 97 20 93 45 60 31 34 34

Sequence


Ensembl Acc Id: ENSRNOT00000017254   ⟹   ENSRNOP00000017254
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2192,287,194 - 192,292,780 (+)Ensembl
Rnor_6.0 Ensembl2207,271,943 - 207,278,004 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000085355   ⟹   ENSRNOP00000073774
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2194,975,401 - 194,981,637 (+)Ensembl
mRatBN7.2 Ensembl2192,287,142 - 192,293,287 (+)Ensembl
Rnor_6.0 Ensembl2207,271,853 - 207,279,314 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000120158   ⟹   ENSRNOP00000097112
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2194,975,242 - 194,983,745 (+)Ensembl
mRatBN7.2 Ensembl2192,287,130 - 192,295,306 (+)Ensembl
RefSeq Acc Id: NM_001106461   ⟹   NP_001099931
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82194,975,586 - 194,981,637 (+)NCBI
mRatBN7.22192,287,241 - 192,293,292 (+)NCBI
Rnor_6.02207,271,959 - 207,278,010 (+)NCBI
Rnor_5.02226,690,856 - 226,697,174 (+)NCBI
RGSC_v3.42200,048,056 - 200,054,107 (+)RGD
Celera2184,753,781 - 184,759,832 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001099931 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI66849 (Get FASTA)   NCBI Sequence Viewer  
  EDL85453 (Get FASTA)   NCBI Sequence Viewer  
  EDL85454 (Get FASTA)   NCBI Sequence Viewer  
  EDL85455 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000017254.4
  ENSRNOP00000073774.2
  ENSRNOP00000097112.1
RefSeq Acc Id: NP_001099931   ⟸   NM_001106461
- UniProtKB: A6K3P6 (UniProtKB/TrEMBL),   A0A0G2K6E0 (UniProtKB/TrEMBL),   B2RYP0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000073774   ⟸   ENSRNOT00000085355
Ensembl Acc Id: ENSRNOP00000017254   ⟸   ENSRNOT00000017254
Ensembl Acc Id: ENSRNOP00000097112   ⟸   ENSRNOT00000120158

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2K6E0-F1-model_v2 AlphaFold A0A0G2K6E0 1-210 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691646
Promoter ID:EPDNEW_R2162
Type:multiple initiation site
Name:Rhoc_1
Description:ras homolog family member C
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02207,271,872 - 207,271,932EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1304965 AgrOrtholog
BioCyc Gene G2FUF-51761 BioCyc
Ensembl Genes ENSRNOG00000012630 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000017254.7 UniProtKB/TrEMBL
  ENSRNOT00000085355.2 UniProtKB/TrEMBL
  ENSRNOT00000120158.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.300 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:9088252 IMAGE-MGC_LOAD
InterPro P-loop_NTPase UniProtKB/TrEMBL
  Ras_GTPase UniProtKB/TrEMBL
  Small_GTP_bd UniProtKB/TrEMBL
  Small_GTPase_Rho UniProtKB/TrEMBL
KEGG Report rno:295342 UniProtKB/TrEMBL
MGC_CLONE MGC:188745 IMAGE-MGC_LOAD
NCBI Gene 295342 ENTREZGENE
PANTHER PTHR24072 UniProtKB/TrEMBL
Pfam Ras UniProtKB/TrEMBL
PhenoGen Rhoc PhenoGen
PRINTS RASTRNSFRMNG UniProtKB/TrEMBL
PROSITE RAB UniProtKB/TrEMBL
  RAS UniProtKB/TrEMBL
  RHO UniProtKB/TrEMBL
RatGTEx ENSRNOG00000012630 RatGTEx
SMART RAB UniProtKB/TrEMBL
  RAS UniProtKB/TrEMBL
  RHO UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/TrEMBL
UniProt A0A0G2K6E0 ENTREZGENE
  A0A8I6AN62_RAT UniProtKB/TrEMBL
  A6K3P6 ENTREZGENE, UniProtKB/TrEMBL
  B2RYP0 ENTREZGENE, UniProtKB/TrEMBL
  F7ERV8_RAT UniProtKB/TrEMBL
UniProt Secondary A0A0G2K6E0 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-10-15 Rhoc  ras homolog family member C  Rhoc  ras homolog gene family, member C  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Rhoc  ras homolog gene family, member C   Rhoc_predicted  ras homolog gene family, member C (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Rhoc_predicted  ras homolog gene family, member C (predicted)      Symbol and Name status set to approved 70820 APPROVED