Tktl2 (transketolase-like 2) - Rat Genome Database

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Gene: Tktl2 (transketolase-like 2) Rattus norvegicus
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Symbol: Tktl2
Name: transketolase-like 2
RGD ID: 1304767
Description: Predicted to enable thiamine pyrophosphate binding activity and transketolase activity. Predicted to be involved in pentose-phosphate shunt, non-oxidative branch. Predicted to be located in cytoplasm. Orthologous to human TKTL2 (transketolase like 2); PARTICIPATES IN pentose phosphate pathway; INTERACTS WITH bisphenol A; Monobutylphthalate; aflatoxin B1 (ortholog).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC290685; RGD1304767; similar to transketolase; transketolase-like protein 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81627,969,009 - 27,976,353 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1627,968,871 - 27,976,442 (-)EnsemblGRCr8
mRatBN7.21623,202,460 - 23,209,741 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1623,202,453 - 23,209,742 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1626,571,169 - 26,573,180 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01630,005,881 - 30,007,892 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01625,944,331 - 25,946,342 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01624,944,197 - 24,951,478 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1624,949,425 - 24,951,612 (-)Ensemblrn6Rnor6.0
Rnor_5.01624,828,047 - 24,835,320 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41624,919,470 - 24,921,481 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1623,323,959 - 23,325,970 (-)NCBICelera
RGSC_v3.11624,919,484 - 24,921,445 (-)NCBI
Cytogenetic Map16p14NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Tktl2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81627,969,009 - 27,976,353 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1627,968,871 - 27,976,442 (-)EnsemblGRCr8
mRatBN7.21623,202,460 - 23,209,741 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1623,202,453 - 23,209,742 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1626,571,169 - 26,573,180 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01630,005,881 - 30,007,892 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01625,944,331 - 25,946,342 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01624,944,197 - 24,951,478 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1624,949,425 - 24,951,612 (-)Ensemblrn6Rnor6.0
Rnor_5.01624,828,047 - 24,835,320 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41624,919,470 - 24,921,481 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1623,323,959 - 23,325,970 (-)NCBICelera
RGSC_v3.11624,919,484 - 24,921,445 (-)NCBI
Cytogenetic Map16p14NCBI
TKTL2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384163,471,095 - 163,473,754 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4163,471,095 - 163,473,754 (-)Ensemblhg38GRCh38
GRCh374164,392,247 - 164,394,906 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364164,611,697 - 164,614,497 (-)NCBIBuild 36Build 36hg18NCBI36
Celera4161,724,510 - 161,727,310 (-)NCBICelera
Cytogenetic Map4q32.2NCBI
HuRef4160,146,102 - 160,148,902 (-)NCBIHuRef
CHM1_14164,368,688 - 164,371,488 (-)NCBICHM1_1
T2T-CHM13v2.04166,818,907 - 166,821,566 (-)NCBIT2T-CHM13v2.0
Tktl2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39866,964,392 - 66,971,851 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl866,964,408 - 66,970,987 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38866,511,740 - 66,519,199 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl866,511,756 - 66,518,335 (+)Ensemblmm10GRCm38
MGSCv37869,035,639 - 69,037,677 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36869,440,745 - 69,442,765 (+)NCBIMGSCv36mm8
Celera869,067,813 - 69,069,849 (+)NCBICelera
Cytogenetic Map8B3.1NCBI
cM Map833.14NCBI
Tktl2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540341,526,398 - 41,528,281 (+)Ensembl
ChiLan1.0NW_00495540341,526,329 - 41,528,591 (+)NCBIChiLan1.0ChiLan1.0
TKTL2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23161,286,275 - 161,289,663 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14161,648,751 - 161,652,139 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04155,738,002 - 155,740,740 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14167,526,340 - 167,529,135 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4167,527,100 - 167,529,268 (-)EnsemblpanPan2panpan1.1
Tktl2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494316,433,388 - 16,436,062 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365552,134,509 - 2,136,392 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365552,134,509 - 2,136,421 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TKTL2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl852,326,545 - 52,329,300 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1852,325,782 - 52,328,286 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2855,453,371 - 55,455,876 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TKTL2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.17109,922,068 - 109,925,412 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603789,746,269 - 89,750,356 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tktl2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475813,364,668 - 13,367,294 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Tktl2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11322,738,447 - 22,740,465 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Tktl2
53 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:73
Count of miRNA genes:69
Interacting mature miRNAs:71
Transcripts:ENSRNOT00000018987
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7411664Foco30Food consumption QTL 30110.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)16435482249354822Rat
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)longest distance run on treadmill (CMO:0001406)1638712345387123Rat
1549842Bp248Blood pressure QTL 2480.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1638712345387123Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)16423421249757901Rat
2307172Activ4Activity QTL 43.710.00023locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)16133425095Rat
737826Alc11Alcohol consumption QTL 113.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16423421266955197Rat
1354584Despr6Despair related QTL 63.10.0067locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16139568015Rat
2303566Bw90Body weight QTL 902body mass (VT:0001259)body weight (CMO:0000012)16139568015Rat
737819Hcas4Hepatocarcinoma susceptibility QTL 44.43liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)16423421253708481Rat
2312663Slep9Serum leptin concentration QTL 90.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1683908666195506Rat
2306902Bp339Blood pressure QTL 3390.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16338679049757901Rat
1354625Despr7Despair related QTL 73.160.016locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16474422249744222Rat
2312660Bw95Body weight QTL 950.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)1683908666195506Rat
2312666Insul16Insulin level QTL 160.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1683908666195506Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161773081872536785Rat
2293343Glom16Glomerulus QTL 167.4kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1683908652786090Rat
2301406Kidm39Kidney mass QTL 390.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)161590580260905802Rat
2312669Stl23Serum triglyceride level QTL 230.01blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1683908666195506Rat
6903319Bw114Body weight QTL 1142.70.0037body mass (VT:0001259)body weight (CMO:0000012)16330168348301683Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
6 2 6 32 34 30 18 9 18 6 65 27 20 12 49 12

Sequence


Ensembl Acc Id: ENSRNOT00000018987   ⟹   ENSRNOP00000018987
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1627,968,871 - 27,976,442 (-)Ensembl
mRatBN7.2 Ensembl1623,202,453 - 23,209,742 (-)Ensembl
Rnor_6.0 Ensembl1624,949,425 - 24,951,612 (-)Ensembl
RefSeq Acc Id: NM_001106080   ⟹   NP_001099550
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81627,974,313 - 27,976,324 (-)NCBI
mRatBN7.21623,207,705 - 23,209,716 (-)NCBI
Rnor_6.01624,949,442 - 24,951,453 (-)NCBI
Rnor_5.01624,828,047 - 24,835,320 (-)NCBI
RGSC_v3.41624,919,470 - 24,921,481 (-)RGD
Celera1623,323,959 - 23,325,970 (-)RGD
Sequence:
RefSeq Acc Id: XM_006253022   ⟹   XP_006253084
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81627,969,009 - 27,976,353 (-)NCBI
mRatBN7.21623,202,460 - 23,209,741 (-)NCBI
Rnor_6.01624,944,197 - 24,951,478 (-)NCBI
Rnor_5.01624,828,047 - 24,835,320 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001099550 (Get FASTA)   NCBI Sequence Viewer  
  XP_006253084 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL75962 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000018987
  ENSRNOP00000018987.1
RefSeq Acc Id: NP_001099550   ⟸   NM_001106080
- UniProtKB: D3ZHE7 (UniProtKB/TrEMBL),   A6KFM0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006253084   ⟸   XM_006253022
- Peptide Label: isoform X1
- UniProtKB: D3ZHE7 (UniProtKB/TrEMBL),   A6KFM0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000018987   ⟸   ENSRNOT00000018987
Protein Domains
Transketolase-like pyrimidine-binding

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZHE7-F1-model_v2 AlphaFold D3ZHE7 1-627 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1304767 AgrOrtholog
BioCyc Gene G2FUF-11658 BioCyc
Ensembl Genes ENSRNOG00000014185 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000018987 ENTREZGENE
  ENSRNOT00000018987.5 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.920 UniProtKB/TrEMBL
  3.40.50.970 UniProtKB/TrEMBL
InterPro THDP-binding UniProtKB/TrEMBL
  Transketo_C/Pyr-ferredox_oxred UniProtKB/TrEMBL
  Transketolase-like UniProtKB/TrEMBL
  Transketolase-like_Pyr-bd UniProtKB/TrEMBL
  Transketolase_BS UniProtKB/TrEMBL
  Transketolase_C UniProtKB/TrEMBL
  Transketolase_N UniProtKB/TrEMBL
KEGG Report rno:290685 UniProtKB/TrEMBL
NCBI Gene 290685 ENTREZGENE
PANTHER TRANSKETOLASE UniProtKB/TrEMBL
  TRANSKETOLASE-LIKE PROTEIN 2 UniProtKB/TrEMBL
Pfam Transket_pyr UniProtKB/TrEMBL
  Transketolase_C UniProtKB/TrEMBL
  Transketolase_N UniProtKB/TrEMBL
PhenoGen Tktl2 PhenoGen
PROSITE TRANSKETOLASE_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000014185 RatGTEx
SMART Transket_pyr UniProtKB/TrEMBL
Superfamily-SCOP SSF52518 UniProtKB/TrEMBL
  Transketo_C_like UniProtKB/TrEMBL
UniProt A6KFM0 ENTREZGENE, UniProtKB/TrEMBL
  D3ZHE7 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Tktl2  transketolase-like 2   Tktl2_predicted  transketolase-like 2 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-30 Tktl2_predicted  transketolase-like 2 (predicted)  RGD1304767_predicted  similar to transketolase (predicted)  Symbol and Name updated 1299863 APPROVED
2005-01-20 RGD1304767_predicted  similar to transketolase (predicted)  LOC290685_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC290685_predicted  similar to transketolase (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL