Gene: Plch2 (phospholipase C, eta 2) Rattus norvegicus
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Symbol:
Plch2
Name:
phospholipase C, eta 2
RGD ID:
1304675
Description:
Predicted to enable phosphatidylinositol-4,5-bisphosphate phospholipase C activity. Predicted to be involved in several processes, including phosphatidylinositol-mediated signaling; phospholipase C-activating G protein-coupled receptor signaling pathway; and release of sequestered calcium ion into cytosol. Predicted to be located in plasma membrane. Orthologous to human PLCH2 (phospholipase C eta 2); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; alpha-Zearalanol.
Type:
protein-coding
RefSeq Status:
VALIDATED
Previously known as:
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2; LOC313756; RGD1304675; similar to FLJ00414 protein
RGD Orthologs
Alliance Orthologs
More Info
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More Info
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
PLCH2 (phospholipase C eta 2)
HGNC
Ensembl, HomoloGene, Inparanoid, NCBI, OrthoDB, Panther
Mus musculus (house mouse):
Plch2 (phospholipase C, eta 2)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):
Plch2 (phospholipase C eta 2)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
PLCH2 (phospholipase C eta 2)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
PLCH2 (phospholipase C eta 2)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Plch2 (phospholipase C eta 2)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
PLCH2 (phospholipase C eta 2)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):
PLCH2 (phospholipase C eta 2)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):
Plch2 (phospholipase C eta 2)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Other homologs 2
Homo sapiens (human):
GRWD1 (glutamate rich WD repeat containing 1)
HGNC
OMA
Alliance orthologs 3
Mus musculus (house mouse):
Plch2 (phospholipase C, eta 2)
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|SonicParanoid)
Homo sapiens (human):
PLCH2 (phospholipase C eta 2)
Alliance
DIOPT (Ensembl Compara|HGNC|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|SonicParanoid)
Danio rerio (zebrafish):
plch2a (phospholipase C, eta 2a)
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|SonicParanoid)
Danio rerio (zebrafish):
plch2a (phospholipase C, eta 2a)
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):
PLC1
Alliance
DIOPT (Hieranoid|InParanoid|OrthoFinder|PANTHER|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):
plch2
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):
plch2
Alliance
DIOPT (Ensembl Compara|OMA|OrthoFinder|PANTHER)
Latest Assembly:
GRCr8 - GRCr8 Assembly
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCr8 5 170,826,543 - 170,885,012 (-) NCBI GRCr8 GRCr8 GRCr8 GRCr8 Ensembl 5 170,826,543 - 170,885,152 (-) Ensembl GRCr8 mRatBN7.2 5 165,544,209 - 165,613,769 (-) NCBI mRatBN7.2 mRatBN7.2 mRatBN7.2 Ensembl 5 165,544,200 - 165,602,356 (-) Ensembl mRatBN7.2 Rnor_6.0 5 172,386,400 - 172,455,965 (-) NCBI Rnor_6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 5 172,388,598 - 172,424,081 (-) Ensembl rn6 Rnor6.0 Rnor_5.0 5 175,842,358 - 175,871,763 (-) NCBI Rnor_5.0 Rnor_5.0 rn5 RGSC_v3.4 5 171,786,340 - 171,815,148 (-) NCBI RGSC_v3.4 RGSC_v3.4 rn4 Celera 5 163,750,666 - 163,780,119 (-) NCBI Celera RGSC_v3.1 5 171,796,834 - 171,825,402 (-) NCBI Cytogenetic Map 5 q36 NCBI
JBrowse:
Imported Disease Annotations - ClinVar
Only show annotations with direct experimental evidence (0 objects hidden)
Plch2 Rat 1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene multiple interactions ISO Plch2 (Mus musculus) 6480464 [2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ... CTD PMID:25510870 Plch2 Rat 1,2-dichloroethane increases expression ISO Plch2 (Mus musculus) 6480464 ethylene dichloride results in increased expression of PLCH2 mRNA CTD PMID:28960355 Plch2 Rat 1,2-dimethylhydrazine multiple interactions ISO Plch2 (Mus musculus) 6480464 [1,2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of PLCH2 mRNA CTD PMID:22206623 Plch2 Rat 2,2',4,4',5,5'-hexachlorobiphenyl multiple interactions ISO Plch2 (Mus musculus) 6480464 [2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ... CTD PMID:25510870 Plch2 Rat 2,2',5,5'-tetrachlorobiphenyl multiple interactions ISO Plch2 (Mus musculus) 6480464 [2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ... CTD PMID:25510870 Plch2 Rat 2,3,7,8-tetrachlorodibenzodioxine increases expression EXP 6480464 Tetrachlorodibenzodioxin results in increased expression of PLCH2 mRNA CTD PMID:32109520 Plch2 Rat 2,4,4'-trichlorobiphenyl multiple interactions ISO Plch2 (Mus musculus) 6480464 [2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ... CTD PMID:25510870 Plch2 Rat 2-hydroxypropanoic acid increases expression ISO PLCH2 (Homo sapiens) 6480464 Lactic Acid results in increased expression of PLCH2 mRNA CTD PMID:30851411 Plch2 Rat 3-isobutyl-1-methyl-7H-xanthine multiple interactions ISO PLCH2 (Homo sapiens) 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] more ... CTD PMID:28628672 Plch2 Rat 4,4'-sulfonyldiphenol decreases methylation ISO Plch2 (Mus musculus) 6480464 bisphenol S results in decreased methylation of PLCH2 exon CTD PMID:33297965 Plch2 Rat 4,4'-sulfonyldiphenol affects methylation ISO Plch2 (Mus musculus) 6480464 bisphenol S affects the methylation of PLCH2 gene CTD PMID:31683443 Plch2 Rat 4,4'-sulfonyldiphenol decreases methylation ISO PLCH2 (Homo sapiens) 6480464 bisphenol S results in decreased methylation of PLCH2 gene CTD PMID:31601247 Plch2 Rat 6-propyl-2-thiouracil decreases expression EXP 6480464 Propylthiouracil results in decreased expression of PLCH2 mRNA CTD PMID:30047161 Plch2 Rat acrylamide decreases expression ISO PLCH2 (Homo sapiens) 6480464 Acrylamide results in decreased expression of PLCH2 mRNA CTD PMID:32763439 Plch2 Rat aflatoxin B1 increases methylation ISO PLCH2 (Homo sapiens) 6480464 Aflatoxin B1 results in increased methylation of PLCH2 3' UTR CTD PMID:30157460 Plch2 Rat aflatoxin B1 decreases methylation ISO PLCH2 (Homo sapiens) 6480464 Aflatoxin B1 results in decreased methylation of PLCH2 intron CTD PMID:30157460 Plch2 Rat Aflatoxin B2 alpha increases methylation ISO PLCH2 (Homo sapiens) 6480464 aflatoxin B2 results in increased methylation of PLCH2 3' UTR CTD PMID:30157460 Plch2 Rat aldrin increases expression ISO Plch2 (Mus musculus) 6480464 Aldrin results in increased expression of PLCH2 mRNA CTD PMID:18579281 Plch2 Rat alpha-Zearalanol multiple interactions EXP 6480464 [Zeranol co-treated with perfluorooctanoic acid] results in decreased expression of PLCH2 mRNA CTD PMID:35163327 Plch2 Rat amitrole decreases expression EXP 6480464 Amitrole results in decreased expression of PLCH2 mRNA CTD PMID:30047161 Plch2 Rat arsenite(3-) decreases expression ISO Plch2 (Mus musculus) 6480464 arsenite results in decreased expression of PLCH2 mRNA CTD PMID:33053406 Plch2 Rat arsenite(3-) multiple interactions ISO PLCH2 (Homo sapiens) 6480464 arsenite inhibits the reaction [G3BP1 protein binds to PLCH2 mRNA] CTD PMID:32406909 Plch2 Rat benzo[a]pyrene increases methylation ISO PLCH2 (Homo sapiens) 6480464 Benzo(a)pyrene results in increased methylation of PLCH2 promoter CTD PMID:27901495 Plch2 Rat benzo[e]pyrene decreases methylation ISO PLCH2 (Homo sapiens) 6480464 benzo(e)pyrene results in decreased methylation of PLCH2 intron CTD PMID:30157460 Plch2 Rat bis(2-ethylhexyl) phthalate multiple interactions ISO Plch2 (Mus musculus) 6480464 [Streptozocin co-treated with Diethylhexyl Phthalate] results in decreased expression of PLCH2 mRNA CTD PMID:31606821 Plch2 Rat bis(2-ethylhexyl) phthalate increases expression ISO Plch2 (Mus musculus) 6480464 Diethylhexyl Phthalate results in increased expression of PLCH2 mRNA CTD PMID:34319233 Plch2 Rat bisphenol A affects expression ISO Plch2 (Mus musculus) 6480464 bisphenol A affects the expression of PLCH2 mRNA CTD PMID:27082013 Plch2 Rat bisphenol A decreases expression ISO Plch2 (Mus musculus) 6480464 bisphenol A results in decreased expression of PLCH2 mRNA CTD PMID:32156529 Plch2 Rat bisphenol A multiple interactions ISO PLCH2 (Homo sapiens) 6480464 [bisphenol A co-treated with Fulvestrant] results in increased methylation of PLCH2 gene; [INS protein co-treated more ... CTD PMID:28628672|PMID:31601247 Plch2 Rat bisphenol A decreases methylation ISO Plch2 (Mus musculus) 6480464 bisphenol A results in decreased methylation of PLCH2 promoter CTD PMID:27312807 Plch2 Rat bisphenol A multiple interactions ISO Plch2 (Mus musculus) 6480464 [XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [bisphenol more ... CTD PMID:27082013 Plch2 Rat bisphenol F multiple interactions ISO PLCH2 (Homo sapiens) 6480464 [bisphenol F co-treated with Fulvestrant] results in increased methylation of PLCH2 gene; [INS protein co-treated more ... CTD PMID:28628672|PMID:31601247 Plch2 Rat butan-1-ol multiple interactions ISO PLCH2 (Homo sapiens) 6480464 [[Gasoline co-treated with 1-Butanol] results in increased abundance of [Particulate Matter co-treated with Polycyclic Aromatic more ... CTD PMID:29432896 Plch2 Rat carbon nanotube decreases expression ISO Plch2 (Mus musculus) 6480464 Nanotubes, Carbon analog results in decreased expression of PLCH2 mRNA; Nanotubes, Carbon results in decreased more ... CTD PMID:25554681 Plch2 Rat chloroethene increases expression ISO Plch2 (Mus musculus) 6480464 Vinyl Chloride results in increased expression of PLCH2 mRNA CTD PMID:18579281 Plch2 Rat chrysene increases expression ISO Plch2 (Mus musculus) 6480464 chrysene results in increased expression of PLCH2 mRNA CTD PMID:26377693 Plch2 Rat clotrimazole decreases expression EXP 6480464 Clotrimazole results in decreased expression of PLCH2 mRNA CTD PMID:30047161 Plch2 Rat cyclosporin A increases expression ISO PLCH2 (Homo sapiens) 6480464 Cyclosporine results in increased expression of PLCH2 mRNA CTD PMID:25562108 Plch2 Rat cyclosporin A decreases methylation ISO PLCH2 (Homo sapiens) 6480464 Cyclosporine results in decreased methylation of PLCH2 promoter CTD PMID:27989131 Plch2 Rat dexamethasone multiple interactions ISO PLCH2 (Homo sapiens) 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] more ... CTD PMID:28628672 Plch2 Rat disodium selenite decreases expression ISO PLCH2 (Homo sapiens) 6480464 Sodium Selenite results in decreased expression of PLCH2 mRNA CTD PMID:18175754 Plch2 Rat ethanol multiple interactions ISO PLCH2 (Homo sapiens) 6480464 [[Gasoline co-treated with Ethanol] results in increased abundance of [Particulate Matter co-treated with Polycyclic Aromatic more ... CTD PMID:29432896 Plch2 Rat ethylparaben decreases expression ISO PLCH2 (Homo sapiens) 6480464 ethyl-p-hydroxybenzoate results in decreased expression of PLCH2 mRNA CTD PMID:37690743 Plch2 Rat folic acid multiple interactions ISO Plch2 (Mus musculus) 6480464 [1,2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of PLCH2 mRNA CTD PMID:22206623 Plch2 Rat fulvestrant multiple interactions ISO PLCH2 (Homo sapiens) 6480464 [bisphenol A co-treated with Fulvestrant] results in increased methylation of PLCH2 gene; [bisphenol F co-treated more ... CTD PMID:31601247 Plch2 Rat GSK-J4 decreases expression ISO PLCH2 (Homo sapiens) 6480464 GSK-J4 results in decreased expression of PLCH2 mRNA CTD PMID:29301935 Plch2 Rat indometacin multiple interactions ISO PLCH2 (Homo sapiens) 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] more ... CTD PMID:28628672 Plch2 Rat methapyrilene decreases methylation ISO PLCH2 (Homo sapiens) 6480464 Methapyrilene results in decreased methylation of PLCH2 intron CTD PMID:30157460 Plch2 Rat methimazole decreases expression EXP 6480464 Methimazole results in decreased expression of PLCH2 mRNA CTD PMID:30047161 Plch2 Rat methoxychlor affects methylation EXP 6480464 Methoxychlor affects the methylation of PLCH2 gene CTD PMID:35440735 Plch2 Rat N,N-diethyl-m-toluamide decreases expression ISO PLCH2 (Homo sapiens) 6480464 DEET results in decreased expression of PLCH2 mRNA CTD PMID:27091632 Plch2 Rat nitrates increases expression EXP 6480464 Nitrates results in increased expression of PLCH2 mRNA CTD PMID:30022042 Plch2 Rat paraquat decreases expression EXP 6480464 Paraquat results in decreased expression of PLCH2 mRNA CTD PMID:32680482 Plch2 Rat PCB138 multiple interactions ISO Plch2 (Mus musculus) 6480464 [2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ... CTD PMID:25510870 Plch2 Rat perfluorohexanesulfonic acid decreases expression ISO Plch2 (Mus musculus) 6480464 perfluorohexanesulfonic acid results in decreased expression of PLCH2 mRNA CTD PMID:37995155 Plch2 Rat perfluorooctanoic acid multiple interactions EXP 6480464 [Zeranol co-treated with perfluorooctanoic acid] results in decreased expression of PLCH2 mRNA CTD PMID:35163327 Plch2 Rat potassium bromate multiple interactions ISO Plch2 (Mus musculus) 6480464 [XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [bisphenol more ... CTD PMID:27082013 Plch2 Rat rac-lactic acid increases expression ISO PLCH2 (Homo sapiens) 6480464 Lactic Acid results in increased expression of PLCH2 mRNA CTD PMID:30851411 Plch2 Rat silicon dioxide increases expression ISO PLCH2 (Homo sapiens) 6480464 Silicon Dioxide analog results in increased expression of PLCH2 mRNA CTD PMID:25895662 Plch2 Rat sodium arsenite increases expression ISO PLCH2 (Homo sapiens) 6480464 sodium arsenite results in increased expression of PLCH2 mRNA CTD PMID:38568856 Plch2 Rat sodium arsenite decreases expression ISO Plch2 (Mus musculus) 6480464 sodium arsenite results in decreased expression of PLCH2 mRNA CTD PMID:37682722 Plch2 Rat streptozocin increases expression ISO Plch2 (Mus musculus) 6480464 Streptozocin results in increased expression of PLCH2 mRNA CTD PMID:31606821 Plch2 Rat streptozocin multiple interactions ISO Plch2 (Mus musculus) 6480464 [Streptozocin co-treated with Diethylhexyl Phthalate] results in decreased expression of PLCH2 mRNA CTD PMID:31606821 Plch2 Rat sulforaphane decreases expression ISO PLCH2 (Homo sapiens) 6480464 sulforaphane results in decreased expression of PLCH2 mRNA CTD PMID:31838189 Plch2 Rat titanium dioxide decreases methylation ISO Plch2 (Mus musculus) 6480464 titanium dioxide results in decreased methylation of PLCH2 gene CTD PMID:35295148 Plch2 Rat tricetin increases expression ISO PLCH2 (Homo sapiens) 6480464 tricetin results in increased expression of PLCH2 mRNA CTD PMID:38654487 Plch2 Rat trichloroethene decreases expression EXP 6480464 Trichloroethylene results in decreased expression of PLCH2 mRNA CTD PMID:33387578 Plch2 Rat Triptolide increases expression ISO Plch2 (Mus musculus) 6480464 triptolide results in increased expression of PLCH2 mRNA CTD PMID:32835833 Plch2 Rat tris(2-butoxyethyl) phosphate affects expression ISO PLCH2 (Homo sapiens) 6480464 tris(2-butoxyethyl) phosphate affects the expression of PLCH2 mRNA CTD PMID:29024780 Plch2 Rat urethane decreases expression ISO PLCH2 (Homo sapiens) 6480464 Urethane results in decreased expression of PLCH2 mRNA CTD PMID:28818685 Plch2 Rat valproic acid increases methylation ISO PLCH2 (Homo sapiens) 6480464 Valproic Acid results in increased methylation of PLCH2 gene CTD PMID:29154799 Plch2 Rat valproic acid affects splicing EXP 6480464 Valproic Acid affects the splicing of PLCH2 mRNA CTD PMID:29427782