Arhgef2 (Rho/Rac guanine nucleotide exchange factor 2) - Rat Genome Database

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Gene: Arhgef2 (Rho/Rac guanine nucleotide exchange factor 2) Rattus norvegicus
Analyze
Symbol: Arhgef2
Name: Rho/Rac guanine nucleotide exchange factor 2
RGD ID: 1304659
Description: Predicted to enable guanyl-nucleotide exchange factor activity; microtubule binding activity; and small GTPase binding activity. Predicted to be involved in several processes, including cytoskeleton organization; positive regulation of macromolecule metabolic process; and regulation of signal transduction. Predicted to act upstream of or within negative regulation of podosome assembly. Is active in glutamatergic synapse and postsynaptic density, intracellular component. Human ortholog(s) of this gene implicated in neurodevelopmental disorder with midbrain and hindbrain malformations. Orthologous to human ARHGEF2 (Rho/Rac guanine nucleotide exchange factor 2); PARTICIPATES IN Reelin signaling pathway; INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: GEF-H1; guanine nucleotide exchange factor H1; LOC310635; MGC95068; rho guanine nucleotide exchange factor 2; rho/rac guanine nucleotide exchange factor (GEF) 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82176,358,909 - 176,416,178 (+)NCBIGRCr8
mRatBN7.22174,061,126 - 174,118,355 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2174,062,976 - 174,118,355 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2181,236,801 - 181,264,663 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02179,259,164 - 179,287,026 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02173,859,429 - 173,887,003 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02187,964,100 - 188,022,847 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2187,977,008 - 188,021,377 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02207,366,791 - 207,423,801 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42180,748,313 - 180,775,656 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12180,698,418 - 180,725,761 (+)NCBI
Celera2168,035,282 - 168,062,671 (+)NCBICelera
Cytogenetic Map2q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-palmitoylglycerol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-azacytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
acetamide  (EXP)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
amitrole  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
benzo[a]pyrene  (ISO)
beta-naphthoflavone  (EXP)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bucladesine  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chloropicrin  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
ciglitazone  (ISO)
cisplatin  (EXP,ISO)
clothianidin  (ISO)
cobalt dichloride  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
coumarin  (ISO)
cyclosporin A  (ISO)
decabromodiphenyl ether  (ISO)
deguelin  (ISO)
dexamethasone  (ISO)
diclofenac  (ISO)
dicrotophos  (ISO)
dorsomorphin  (ISO)
ethanol  (ISO)
flubendazole  (ISO)
fluoranthene  (ISO)
folic acid  (ISO)
FR900359  (ISO)
gentamycin  (EXP)
hydroquinone  (ISO)
hydroquinone O-beta-D-glucopyranoside  (ISO)
indometacin  (ISO)
ivermectin  (ISO)
L-methionine  (ISO)
lead(0)  (ISO)
lipopolysaccharide  (ISO)
mebendazole  (ISO)
medroxyprogesterone acetate  (ISO)
methamphetamine  (ISO)
methapyrilene  (EXP)
methylseleninic acid  (ISO)
microcystin-LR  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (EXP)
nickel atom  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
pentachlorophenol  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
picoxystrobin  (ISO)
pirinixic acid  (ISO)
piroxicam  (ISO)
resveratrol  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
simvastatin  (ISO)
sinapic acid  (ISO)
sodium arsenite  (ISO)
sunitinib  (ISO)
testosterone  (EXP)
thapsigargin  (ISO)
thifluzamide  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
trichloroethene  (EXP)
triphenyl phosphate  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
tungsten  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
xylitol  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
actin filament organization  (IBA,IEA,ISO,ISS)
asymmetric neuroblast division  (IEA,ISO,ISS)
cell differentiation  (IEA)
cell division  (IEA)
cell morphogenesis  (IBA,IEA,ISO,ISS)
cellular hyperosmotic response  (ISO)
cellular response to muramyl dipeptide  (IEA,ISO,ISS)
cellular response to tumor necrosis factor  (ISO)
establishment of mitotic spindle orientation  (ISO)
innate immune response  (IEA)
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors  (ISO)
negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress  (ISO)
negative regulation of microtubule depolymerization  (IEA,ISO,ISS)
negative regulation of necroptotic process  (ISO)
negative regulation of neurogenesis  (ISO)
negative regulation of podosome assembly  (ISO)
nervous system development  (IEA)
positive regulation of epidermal growth factor receptor signaling pathway  (ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of interleukin-6 production  (IEA,ISO,ISS)
positive regulation of metalloendopeptidase activity  (ISO)
positive regulation of neuron differentiation  (IBA,IEA,ISO,ISS)
positive regulation of neuron migration  (ISO,ISS)
positive regulation of NF-kappaB transcription factor activity  (IEA,ISO,ISS)
positive regulation of p38MAPK cascade  (ISO)
positive regulation of peptidyl-tyrosine phosphorylation  (IEA,ISO,ISS)
positive regulation of Rac protein signal transduction  (ISO)
positive regulation of transcription by RNA polymerase II  (IEA,ISO,ISS)
positive regulation of tumor necrosis factor production  (IEA,ISO,ISS)
positive regulation of wound healing  (ISO)
regulation of Rho protein signal transduction  (IBA,ISO)
tumor necrosis factor-mediated signaling pathway  (ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. AMPA receptor and GEF-H1/Lfc complex regulates dendritic spine development through RhoA signaling cascade. Kang MG, etal., Proc Natl Acad Sci U S A. 2009 Mar 3;106(9):3549-54. doi: 10.1073/pnas.0812861106. Epub 2009 Feb 10.
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
5. GOA pipeline RGD automated data pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:9857026   PMID:11912491   PMID:12477932   PMID:15996550   PMID:17114649   PMID:19043560   PMID:19448628   PMID:21352810   PMID:21423176   PMID:21525035   PMID:21887730   PMID:22711822  
PMID:23389627   PMID:23611588   PMID:23648943   PMID:24356971   PMID:25447939   PMID:26866809   PMID:27003208   PMID:28453519   PMID:30053369  


Genomics

Comparative Map Data
Arhgef2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82176,358,909 - 176,416,178 (+)NCBIGRCr8
mRatBN7.22174,061,126 - 174,118,355 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2174,062,976 - 174,118,355 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2181,236,801 - 181,264,663 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02179,259,164 - 179,287,026 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02173,859,429 - 173,887,003 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02187,964,100 - 188,022,847 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2187,977,008 - 188,021,377 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02207,366,791 - 207,423,801 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42180,748,313 - 180,775,656 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12180,698,418 - 180,725,761 (+)NCBI
Celera2168,035,282 - 168,062,671 (+)NCBICelera
Cytogenetic Map2q34NCBI
ARHGEF2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381155,946,854 - 155,979,617 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1155,946,851 - 156,007,070 (-)EnsemblGRCh38hg38GRCh38
GRCh371155,916,645 - 155,949,408 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361154,183,269 - 154,214,575 (-)NCBINCBI36Build 36hg18NCBI36
Build 341152,729,718 - 152,761,024NCBI
Celera1128,989,509 - 129,021,228 (-)NCBICelera
Cytogenetic Map1q22NCBI
HuRef1127,277,505 - 127,309,545 (-)NCBIHuRef
CHM1_11157,312,414 - 157,344,123 (-)NCBICHM1_1
T2T-CHM13v2.01155,084,975 - 155,117,734 (-)NCBIT2T-CHM13v2.0
Arhgef2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39388,500,427 - 88,556,839 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl388,513,273 - 88,555,359 (+)EnsemblGRCm39 Ensembl
GRCm38388,593,105 - 88,649,532 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl388,605,966 - 88,648,052 (+)EnsemblGRCm38mm10GRCm38
MGSCv37388,425,028 - 88,451,974 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36388,707,065 - 88,732,841 (+)NCBIMGSCv36mm8
Celera388,660,982 - 88,688,007 (+)NCBICelera
Cytogenetic Map3F1NCBI
cM Map338.9NCBI
Arhgef2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555452,149,107 - 2,197,153 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555452,149,107 - 2,192,986 (-)NCBIChiLan1.0ChiLan1.0
ARHGEF2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2193,846,340 - 93,905,998 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1193,591,947 - 93,637,756 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01131,282,514 - 131,326,535 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11135,112,040 - 135,177,186 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1135,112,040 - 135,159,299 (-)Ensemblpanpan1.1panPan2
ARHGEF2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1741,835,322 - 41,850,488 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl741,812,353 - 41,850,488 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha741,324,784 - 41,340,572 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0741,671,709 - 41,718,518 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl741,679,446 - 41,718,514 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1741,482,812 - 41,498,603 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0741,536,462 - 41,552,253 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0741,820,637 - 41,836,427 (+)NCBIUU_Cfam_GSD_1.0
Arhgef2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505826,182,941 - 26,216,578 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365805,214,401 - 5,245,021 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365805,213,323 - 5,230,861 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ARHGEF2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl494,026,386 - 94,080,420 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1494,026,391 - 94,082,206 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24102,769,501 - 102,823,704 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ARHGEF2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1207,884,220 - 7,927,738 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl207,905,662 - 7,930,657 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660387,176,051 - 7,229,194 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Arhgef2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248851,311,512 - 1,362,730 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248851,314,885 - 1,362,730 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Arhgef2
361 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:409
Count of miRNA genes:217
Interacting mature miRNAs:272
Transcripts:ENSRNOT00000027182
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358356Srcrt1Stress Responsive Cort QTL13.66blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)2161699179222436696Rat
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2114837527211674221Rat
1331734Bp204Blood pressure QTL 2043.61192arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2168358098223265385Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
6907363Bp357Blood pressure QTL 3574.10.002arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2129540907174540907Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
1298076Bp166Blood pressure QTL 1660.0009arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2136445150202447032Rat
70162Bp63Blood pressure QTL 635.64arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)2169745596214745596Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2114837675212549332Rat
12879836Kidm61Kidney mass QTL 610.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2152413072185122374Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)278665619219826953Rat
10043136Iddm54Insulin dependent diabetes mellitus QTL 543.40.0001blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)2143657411190602963Rat
12879837Am2Aortic mass QTL 20.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)2152413072185122374Rat
1302793Bw16Body weight QTL 1650.0001body mass (VT:0001259)body weight (CMO:0000012)2157142209202446871Rat
12879838Cm86Cardiac mass QTL 860.002heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2152413072185122374Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)243154682202446871Rat
12879839Cm85Cardiac mass QTL 850.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)2152413072185122374Rat
61469Bp16Blood pressure QTL 165.64arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)2169745596214745596Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)2135552573202446871Rat
1549833Bp257Blood pressure QTL 2570.003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2168354880185122374Rat
1358900Bw48Body weight QTL 484.88body mass (VT:0001259)body weight (CMO:0000012)2157142078211086598Rat
61473Bp19Blood pressure QTL 196.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2172710921175950118Rat
12879845Cm89Cardiac mass QTL 890.008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2152413072175950118Rat
1359030Bp277Blood pressure QTL 277arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2114837527185876470Rat
12879846Cm90Cardiac mass QTL 900.011heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)2152413072175950118Rat
12879847Am4Aortic mass QTL 40.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)2152413072175950118Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)256043031202447032Rat
12879840Bw179Body weight QTL 1790.005body mass (VT:0001259)body weight (CMO:0000012)2152413072185122374Rat
1581502Esta3Estrogen-induced thymic atrophy QTL 3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2136916935189599348Rat
1359032Hrtrt18Heart rate QTL 18heart pumping trait (VT:2000009)heart rate (CMO:0000002)2157142078192625452Rat
2301966Bp322Blood pressure QTL 3223.58arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150540301202447032Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118275202447032Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)281689826221035911Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561249053267Rat
1359022Ppulsi1Prepulse inhibition QTL 13.63prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)2136916935213594495Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)276539322202447032Rat
8662843Vetf9Vascular elastic tissue fragility QTL 92.05thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2157142078226277316Rat
631501Bp101Blood pressure QTL 1012.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150341684202446871Rat
2301415Cm67Cardiac mass QTL 670.003heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)2152413072175950118Rat
2307174Activ3Activity QTL 34.830.000058locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)2168594495213594495Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2141194931223265385Rat
71113Cari2Carrageenan-induced inflammation QTL 22.70.009hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)2141596551202447032Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2141194931223265385Rat
11565180Kidm56Kidney mass QTL 560.003kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2152413072175950118Rat
1598805Memor8Memory QTL 83exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)2150341585189039377Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2112456140212696837Rat
11565181Bw176Body weight QTL 1760.002body mass (VT:0001259)body weight (CMO:0000012)2152413072175950118Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
724568Uae13Urinary albumin excretion QTL 134.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)2143157029210020885Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1300165Rf9Renal function QTL 93.28kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)2133914684202447032Rat
61401Niddm2Non-insulin dependent diabetes mellitus QTL 24.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2144599348189599348Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2112456140212696837Rat
1641925Alcrsp2Alcohol response QTL 2response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561221167075Rat
1354609Niddm62Non-insulin dependent diabetes mellitus QTL 624.720.000006insulin secretion trait (VT:0003564)plasma insulin level (CMO:0000342)2150540301202447032Rat
1598833Bp295Blood pressure QTL 2953.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2147798556192798556Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)281754530222436696Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)246123260202447032Rat
631522Bp74Blood pressure QTL 740.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2172710921184114403Rat
7488927Bp365Blood pressure QTL 3650.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2162765032207765032Rat
1598838Bp290Blood pressure QTL 2901.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2166539266211539266Rat
7488925Bp364Blood pressure QTL 3640.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2160564068205564068Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607182042367Rat
2306901Bp337Blood pressure QTL 3370.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2164073756227146641Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)274786664206665859Rat
6903312Bw112Body weight QTL 1123.20.0013body mass (VT:0001259)body weight (CMO:0000012)2143657569184114274Rat
7488904Bp363Blood pressure QTL 3630.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2172982062175950118Rat
1354601Slep1Serum leptin concentration QTL 15.39blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)243171017184114403Rat

Markers in Region
D2Rat42  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22174,110,900 - 174,111,027 (+)MAPPERmRatBN7.2
Rnor_6.02188,013,923 - 188,014,049NCBIRnor6.0
Rnor_5.02207,416,346 - 207,416,472UniSTSRnor5.0
RGSC_v3.42180,768,205 - 180,768,331UniSTSRGSC3.4
RGSC_v3.42180,768,203 - 180,768,626RGDRGSC3.4
RGSC_v3.12180,718,311 - 180,718,437RGD
Celera2168,055,216 - 168,055,342UniSTS
RH 3.4 Map21154.8RGD
RH 3.4 Map21154.8UniSTS
RH 2.0 Map2504.6RGD
SHRSP x BN Map270.0198RGD
FHH x ACI Map276.5599RGD
Cytogenetic Map2q34UniSTS
RH141382  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22174,117,902 - 174,118,091 (+)MAPPERmRatBN7.2
Rnor_6.02188,020,925 - 188,021,113NCBIRnor6.0
Rnor_5.02207,423,349 - 207,423,537UniSTSRnor5.0
RGSC_v3.42180,775,208 - 180,775,396UniSTSRGSC3.4
Celera2168,062,223 - 168,062,411UniSTS
RH 3.4 Map21155.2UniSTS
Cytogenetic Map2q34UniSTS
RH134330  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22174,117,992 - 174,118,208 (+)MAPPERmRatBN7.2
Rnor_6.02188,021,015 - 188,021,230NCBIRnor6.0
Rnor_5.02207,423,439 - 207,423,654UniSTSRnor5.0
RGSC_v3.42180,775,298 - 180,775,513UniSTSRGSC3.4
Celera2168,062,313 - 168,062,528UniSTS
RH 3.4 Map21154.3UniSTS
Cytogenetic Map2q34UniSTS
RH124802  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22174,117,995 - 174,118,105 (+)MAPPERmRatBN7.2
Rnor_6.02188,021,018 - 188,021,127NCBIRnor6.0
Rnor_5.02207,423,442 - 207,423,551UniSTSRnor5.0
RGSC_v3.42180,775,301 - 180,775,410UniSTSRGSC3.4
Celera2168,062,316 - 168,062,425UniSTS
Cytogenetic Map2q34UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001012079 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006232643 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006232644 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006232646 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006232647 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006232648 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006232651 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006232652 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006232653 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006232654 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008761152 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017590882 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017590883 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039102312 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063281840 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063281841 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063281842 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC117919 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC090078 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212011 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000002 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000027182   ⟹   ENSRNOP00000027182
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2174,090,751 - 174,118,344 (+)Ensembl
Rnor_6.0 Ensembl2187,993,758 - 188,021,377 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000081531   ⟹   ENSRNOP00000071595
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2174,062,976 - 174,118,355 (+)Ensembl
Rnor_6.0 Ensembl2187,977,008 - 188,020,424 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000092759
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl2188,015,141 - 188,016,255 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000092819   ⟹   ENSRNOP00000076041
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl2187,990,242 - 188,005,855 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000092951   ⟹   ENSRNOP00000076060
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2174,062,976 - 174,118,355 (+)Ensembl
Rnor_6.0 Ensembl2187,977,012 - 188,002,479 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000093016   ⟹   ENSRNOP00000076058
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2174,099,054 - 174,110,665 (+)Ensembl
Rnor_6.0 Ensembl2187,988,995 - 188,006,094 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000093033   ⟹   ENSRNOP00000076068
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2174,085,751 - 174,118,355 (+)Ensembl
Rnor_6.0 Ensembl2187,988,925 - 188,021,377 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000099415   ⟹   ENSRNOP00000095755
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2174,099,326 - 174,118,355 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000105386   ⟹   ENSRNOP00000094178
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2174,075,211 - 174,118,355 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000119126   ⟹   ENSRNOP00000091462
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2174,099,054 - 174,118,355 (+)Ensembl
RefSeq Acc Id: NM_001012079   ⟹   NP_001012079
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82176,388,599 - 176,416,174 (+)NCBI
mRatBN7.22174,090,776 - 174,118,351 (+)NCBI
Rnor_6.02187,993,798 - 188,021,373 (+)NCBI
Rnor_5.02207,366,791 - 207,423,801 (+)NCBI
RGSC_v3.42180,748,313 - 180,775,656 (+)RGD
Celera2168,035,282 - 168,062,671 (+)RGD
Sequence:
RefSeq Acc Id: XM_006232643   ⟹   XP_006232705
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82176,358,909 - 176,416,178 (+)NCBI
mRatBN7.22174,061,127 - 174,118,355 (+)NCBI
Rnor_6.02187,964,100 - 188,022,847 (+)NCBI
Rnor_5.02207,366,791 - 207,423,801 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006232646   ⟹   XP_006232708
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82176,372,194 - 176,416,178 (+)NCBI
mRatBN7.22174,075,324 - 174,118,355 (+)NCBI
Rnor_6.02187,978,376 - 188,022,847 (+)NCBI
Rnor_5.02207,366,791 - 207,423,801 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006232651   ⟹   XP_006232713
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82176,394,160 - 176,416,178 (+)NCBI
mRatBN7.22174,098,730 - 174,118,355 (+)NCBI
Rnor_6.02188,001,773 - 188,022,847 (+)NCBI
Rnor_5.02207,366,791 - 207,423,801 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006232652   ⟹   XP_006232714
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82176,388,859 - 176,416,178 (+)NCBI
mRatBN7.22174,091,031 - 174,118,355 (+)NCBI
Rnor_6.02187,993,974 - 188,022,847 (+)NCBI
Rnor_5.02207,366,791 - 207,423,801 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008761152   ⟹   XP_008759374
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82176,383,516 - 176,416,178 (+)NCBI
mRatBN7.22174,085,675 - 174,118,355 (+)NCBI
Rnor_6.02187,988,028 - 188,022,847 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017590882   ⟹   XP_017446371
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82176,358,951 - 176,416,178 (+)NCBI
mRatBN7.22174,061,126 - 174,118,355 (+)NCBI
Rnor_6.02187,977,007 - 188,022,847 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039102312   ⟹   XP_038958240
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82176,370,104 - 176,416,178 (+)NCBI
mRatBN7.22174,072,272 - 174,118,355 (+)NCBI
RefSeq Acc Id: XM_063281840   ⟹   XP_063137910
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82176,372,194 - 176,416,178 (+)NCBI
RefSeq Acc Id: XM_063281841   ⟹   XP_063137911
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82176,390,383 - 176,416,178 (+)NCBI
RefSeq Acc Id: XM_063281842   ⟹   XP_063137912
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82176,388,490 - 176,416,178 (+)NCBI
RefSeq Acc Id: NP_001012079   ⟸   NM_001012079
- UniProtKB: Q5FVC2 (UniProtKB/Swiss-Prot),   A6J694 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006232705   ⟸   XM_006232643
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K0V4 (UniProtKB/TrEMBL),   A0A1B0GWX8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006232708   ⟸   XM_006232646
- Peptide Label: isoform X3
- UniProtKB: A0A8I6AK99 (UniProtKB/TrEMBL),   A6J694 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006232714   ⟸   XM_006232652
- Peptide Label: isoform X9
- UniProtKB: A6J694 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006232713   ⟸   XM_006232651
- Peptide Label: isoform X7
- UniProtKB: A0A8I6AFM5 (UniProtKB/TrEMBL),   A6J694 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008759374   ⟸   XM_008761152
- Peptide Label: isoform X8
- UniProtKB: A0A1B0GWY5 (UniProtKB/TrEMBL),   A6J694 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017446371   ⟸   XM_017590882
- Peptide Label: isoform X2
- UniProtKB: A0A1B0GWX8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000076041   ⟸   ENSRNOT00000092819
Ensembl Acc Id: ENSRNOP00000076060   ⟸   ENSRNOT00000092951
Ensembl Acc Id: ENSRNOP00000071595   ⟸   ENSRNOT00000081531
Ensembl Acc Id: ENSRNOP00000076068   ⟸   ENSRNOT00000093033
Ensembl Acc Id: ENSRNOP00000076058   ⟸   ENSRNOT00000093016
Ensembl Acc Id: ENSRNOP00000027182   ⟸   ENSRNOT00000027182
RefSeq Acc Id: XP_038958240   ⟸   XM_039102312
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K0V4 (UniProtKB/TrEMBL),   A0A1B0GWX8 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000091462   ⟸   ENSRNOT00000119126
Ensembl Acc Id: ENSRNOP00000094178   ⟸   ENSRNOT00000105386
Ensembl Acc Id: ENSRNOP00000095755   ⟸   ENSRNOT00000099415
RefSeq Acc Id: XP_063137910   ⟸   XM_063281840
- Peptide Label: isoform X4
- UniProtKB: A6J694 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063137912   ⟸   XM_063281842
- Peptide Label: isoform X6
- UniProtKB: A6J694 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063137911   ⟸   XM_063281841
- Peptide Label: isoform X5
- UniProtKB: A6J694 (UniProtKB/TrEMBL)
Protein Domains
DH   PH   Phorbol-ester/DAG-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5FVC2-F1-model_v2 AlphaFold Q5FVC2 1-985 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691452
Promoter ID:EPDNEW_R1973
Type:multiple initiation site
Name:Arhgef2_3
Description:Rho/Rac guanine nucleotide exchange factor 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R1975  EPDNEW_R1974  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02187,977,008 - 187,977,068EPDNEW
RGD ID:13691454
Promoter ID:EPDNEW_R1974
Type:single initiation site
Name:Arhgef2_1
Description:Rho/Rac guanine nucleotide exchange factor 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R1975  EPDNEW_R1973  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02187,988,925 - 187,988,985EPDNEW
RGD ID:13691450
Promoter ID:EPDNEW_R1975
Type:multiple initiation site
Name:Arhgef2_2
Description:Rho/Rac guanine nucleotide exchange factor 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R1973  EPDNEW_R1974  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02187,993,781 - 187,993,841EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1304659 AgrOrtholog
BioCyc Gene G2FUF-52473 BioCyc
Ensembl Genes ENSRNOG00000020027 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055024384 UniProtKB/Swiss-Prot
  ENSRNOG00060032612 UniProtKB/Swiss-Prot
  ENSRNOG00065028306 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000027182.8 UniProtKB/Swiss-Prot
  ENSRNOT00000081531.2 UniProtKB/TrEMBL
  ENSRNOT00000092951.2 UniProtKB/TrEMBL
  ENSRNOT00000093016.2 UniProtKB/TrEMBL
  ENSRNOT00000093033.2 UniProtKB/TrEMBL
  ENSRNOT00000099415.1 UniProtKB/TrEMBL
  ENSRNOT00000105386.1 UniProtKB/TrEMBL
  ENSRNOT00000119126.1 UniProtKB/TrEMBL
  ENSRNOT00055042129 UniProtKB/Swiss-Prot
  ENSRNOT00060056539 UniProtKB/Swiss-Prot
  ENSRNOT00065049018 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.900.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.30.29.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.60.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7125049 IMAGE-MGC_LOAD
InterPro ARHGEF2_PH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C1-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DBL_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DH-domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PE/DAG-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH_16 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rho_GEF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:310635 UniProtKB/Swiss-Prot
MGC_CLONE MGC:95068 IMAGE-MGC_LOAD
NCBI Gene 310635 ENTREZGENE
PANTHER AGAP007712-PA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam C1_1 UniProtKB/TrEMBL
  PH_16 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RhoGEF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Arhgef2 PhenoGen
PROSITE DH_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH_DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZF_DAG_PE_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZF_DAG_PE_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000020027 RatGTEx
  ENSRNOG00055024384 RatGTEx
  ENSRNOG00060032612 RatGTEx
  ENSRNOG00065028306 RatGTEx
SMART RhoGEF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00109 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00233 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF48065 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57889 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2K0V4 ENTREZGENE, UniProtKB/TrEMBL
  A0A1B0GWX6_RAT UniProtKB/TrEMBL
  A0A1B0GWX8 ENTREZGENE, UniProtKB/TrEMBL
  A0A1B0GWY5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AFM5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AK99 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GLA8_RAT UniProtKB/TrEMBL
  A6J694 ENTREZGENE, UniProtKB/TrEMBL
  ARHG2_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-19 Arhgef2  Rho/Rac guanine nucleotide exchange factor 2  Arhgef2  rho/rac guanine nucleotide exchange factor (GEF) 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Arhgef2  rho/rac guanine nucleotide exchange factor (GEF) 2  Arhgef2_predicted  rho/rac guanine nucleotide exchange factor (GEF) 2 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Arhgef2_predicted  rho/rac guanine nucleotide exchange factor (GEF) 2 (predicted)      Symbol and Name status set to approved 70820 APPROVED