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Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Syne3 | Rat | 17beta-estradiol | multiple interactions | ISO | SYNE3 (Homo sapiens) | 6480464 | [Estradiol binds to ESR2 protein] which results in increased expression of SYNE3 mRNA | CTD | PMID:20404318 | Syne3 | Rat | 17beta-estradiol | increases expression | ISO | SYNE3 (Homo sapiens) | 6480464 | Estradiol results in increased expression of SYNE3 mRNA | CTD | PMID:31614463 | Syne3 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of SYNE3 mRNA | CTD | PMID:33387578 | Syne3 | Rat | 2,4-dibromophenyl 2,4,5-tribromophenyl ether | increases expression | ISO | SYNE3 (Homo sapiens) | 6480464 | 2 more ... | CTD | PMID:26705709 | Syne3 | Rat | 4,4'-sulfonyldiphenol | decreases expression | ISO | Syne3 (Mus musculus) | 6480464 | bisphenol S results in decreased expression of SYNE3 mRNA | CTD | PMID:33297965 | Syne3 | Rat | 4-hydroxyphenyl retinamide | decreases expression | ISO | Syne3 (Mus musculus) | 6480464 | Fenretinide results in decreased expression of SYNE3 mRNA | CTD | PMID:28973697 | Syne3 | Rat | 6-propyl-2-thiouracil | decreases expression | EXP | | 6480464 | Propylthiouracil results in decreased expression of SYNE3 mRNA | CTD | PMID:24780913 | Syne3 | Rat | aflatoxin B1 | increases methylation | ISO | SYNE3 (Homo sapiens) | 6480464 | Aflatoxin B1 results in increased methylation of SYNE3 gene | CTD | PMID:27153756 | Syne3 | Rat | aflatoxin B1 | decreases expression | EXP | | 6480464 | Aflatoxin B1 results in decreased expression of SYNE3 mRNA | CTD | PMID:33354967 | Syne3 | Rat | Aflatoxin B2 alpha | increases methylation | ISO | SYNE3 (Homo sapiens) | 6480464 | aflatoxin B2 results in increased methylation of SYNE3 3' UTR | CTD | PMID:30157460 | Syne3 | Rat | all-trans-retinoic acid | decreases expression | ISO | SYNE3 (Homo sapiens) | 6480464 | Tretinoin results in decreased expression of SYNE3 mRNA | CTD | PMID:23724009 | Syne3 | Rat | arsane | affects methylation | ISO | SYNE3 (Homo sapiens) | 6480464 | Arsenic affects the methylation of SYNE3 gene | CTD | PMID:25304211 | Syne3 | Rat | arsenic atom | affects methylation | ISO | SYNE3 (Homo sapiens) | 6480464 | Arsenic affects the methylation of SYNE3 gene | CTD | PMID:25304211 | Syne3 | Rat | benzo[a]pyrene | increases expression | ISO | Syne3 (Mus musculus) | 6480464 | Benzo(a)pyrene results in increased expression of SYNE3 mRNA | CTD | PMID:27195522 | Syne3 | Rat | benzo[a]pyrene | affects methylation | ISO | SYNE3 (Homo sapiens) | 6480464 | Benzo(a)pyrene affects the methylation of SYNE3 promoter | CTD | PMID:27901495 | Syne3 | Rat | benzo[a]pyrene | decreases expression | ISO | SYNE3 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased expression of SYNE3 mRNA | CTD | PMID:22316170 and PMID:26238291 | Syne3 | Rat | benzo[a]pyrene diol epoxide I | decreases expression | ISO | SYNE3 (Homo sapiens) | 6480464 | 7 more ... | CTD | PMID:26238291 | Syne3 | Rat | bisphenol A | affects expression | EXP | | 6480464 | bisphenol A affects the expression of SYNE3 mRNA | CTD | PMID:25181051 | Syne3 | Rat | bisphenol A | increases expression | ISO | Syne3 (Mus musculus) | 6480464 | bisphenol A results in increased expression of SYNE3 mRNA | CTD | PMID:32156529 | Syne3 | Rat | bisphenol A | increases expression | ISO | SYNE3 (Homo sapiens) | 6480464 | bisphenol A analog results in increased expression of SYNE3 mRNA and bisphenol A results in increased expression of SYNE3 mRNA | CTD | PMID:29275510 more ... | Syne3 | Rat | bisphenol A | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with Genistein] results in decreased methylation of SYNE3 gene | CTD | PMID:28505145 | Syne3 | Rat | cadmium dichloride | decreases expression | ISO | SYNE3 (Homo sapiens) | 6480464 | Cadmium Chloride results in decreased expression of SYNE3 mRNA | CTD | PMID:38568856 | Syne3 | Rat | carbon nanotube | increases expression | ISO | Syne3 (Mus musculus) | 6480464 | Nanotubes and Carbon analog results in increased expression of SYNE3 mRNA | CTD | PMID:25554681 | Syne3 | Rat | cyclosporin A | increases expression | ISO | SYNE3 (Homo sapiens) | 6480464 | Cyclosporine results in increased expression of SYNE3 mRNA | CTD | PMID:25562108 and PMID:27989131 | Syne3 | Rat | dexamethasone | increases expression | ISO | SYNE3 (Homo sapiens) | 6480464 | Dexamethasone results in increased expression of SYNE3 mRNA | CTD | PMID:25047013 | Syne3 | Rat | Dibutyl phosphate | affects expression | ISO | SYNE3 (Homo sapiens) | 6480464 | di-n-butylphosphoric acid affects the expression of SYNE3 mRNA | CTD | PMID:37042841 | Syne3 | Rat | dioxygen | decreases expression | ISO | SYNE3 (Homo sapiens) | 6480464 | Oxygen deficiency results in decreased expression of SYNE3 mRNA | CTD | PMID:26516004 | Syne3 | Rat | dorsomorphin | multiple interactions | ISO | SYNE3 (Homo sapiens) | 6480464 | [NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | Syne3 | Rat | doxorubicin | decreases expression | ISO | SYNE3 (Homo sapiens) | 6480464 | Doxorubicin results in decreased expression of SYNE3 mRNA | CTD | PMID:29803840 | Syne3 | Rat | fipronil | multiple interactions | ISO | SYNE3 (Homo sapiens) | 6480464 | [fipronil co-treated with DEET] results in decreased expression of SYNE3 mRNA | CTD | PMID:28991164 | Syne3 | Rat | formaldehyde | increases expression | ISO | SYNE3 (Homo sapiens) | 6480464 | Formaldehyde results in increased expression of SYNE3 mRNA | CTD | PMID:27664576 | Syne3 | Rat | furan | decreases expression | EXP | | 6480464 | furan results in decreased expression of SYNE3 mRNA | CTD | PMID:25539665 | Syne3 | Rat | genistein | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with Genistein] results in decreased methylation of SYNE3 gene | CTD | PMID:28505145 | Syne3 | Rat | glycidol | decreases expression | EXP | | 6480464 | glycidol results in decreased expression of SYNE3 mRNA | CTD | PMID:24395379 | Syne3 | Rat | glyphosate | increases expression | ISO | Syne3 (Mus musculus) | 6480464 | Glyphosate results in increased expression of SYNE3 mRNA | CTD | PMID:35897073 | Syne3 | Rat | lipopolysaccharide | multiple interactions | ISO | SYNE3 (Homo sapiens) | 6480464 | [S-(1 and 2-dichlorovinyl)cysteine co-treated with Lipopolysaccharides] results in decreased expression of SYNE3 mRNA | CTD | PMID:35811015 | Syne3 | Rat | menadione | affects expression | ISO | SYNE3 (Homo sapiens) | 6480464 | Vitamin K 3 affects the expression of SYNE3 mRNA | CTD | PMID:20044591 | Syne3 | Rat | methimazole | increases expression | EXP | | 6480464 | Methimazole results in increased expression of SYNE3 mRNA | CTD | PMID:30047161 | Syne3 | Rat | mono(2-ethylhexyl) phthalate | increases expression | ISO | SYNE3 (Homo sapiens) | 6480464 | mono-(2-ethylhexyl)phthalate results in increased expression of SYNE3 mRNA | CTD | PMID:36695872 | Syne3 | Rat | N,N-diethyl-m-toluamide | multiple interactions | ISO | SYNE3 (Homo sapiens) | 6480464 | [fipronil co-treated with DEET] results in decreased expression of SYNE3 mRNA | CTD | PMID:28991164 | Syne3 | Rat | N-acetyl-1,4-benzoquinone imine | affects response to substance | ISO | SYNE3 (Homo sapiens) | 6480464 | SYNE3 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine | CTD | PMID:21177773 | Syne3 | Rat | panobinostat | multiple interactions | ISO | SYNE3 (Homo sapiens) | 6480464 | [NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SYNE3 mRNA | CTD | PMID:27188386 | Syne3 | Rat | panobinostat | increases expression | ISO | SYNE3 (Homo sapiens) | 6480464 | panobinostat results in increased expression of SYNE3 mRNA | CTD | PMID:26272509 | Syne3 | Rat | paracetamol | decreases expression | ISO | SYNE3 (Homo sapiens) | 6480464 | Acetaminophen results in decreased expression of SYNE3 mRNA | CTD | PMID:21420995 | Syne3 | Rat | paracetamol | decreases expression | EXP | | 6480464 | Acetaminophen results in decreased expression of SYNE3 mRNA | CTD | PMID:33387578 | Syne3 | Rat | phenylmercury acetate | multiple interactions | ISO | SYNE3 (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SYNE3 mRNA | CTD | PMID:27188386 | Syne3 | Rat | resveratrol | decreases expression | ISO | Syne3 (Mus musculus) | 6480464 | resveratrol results in decreased expression of SYNE3 protein | CTD | PMID:25505154 | Syne3 | Rat | S-(1,2-dichlorovinyl)-L-cysteine | multiple interactions | ISO | SYNE3 (Homo sapiens) | 6480464 | [S-(1 and 2-dichlorovinyl)cysteine co-treated with Lipopolysaccharides] results in decreased expression of SYNE3 mRNA | CTD | PMID:35811015 | Syne3 | Rat | SB 431542 | multiple interactions | ISO | SYNE3 (Homo sapiens) | 6480464 | [NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | Syne3 | Rat | silicon dioxide | decreases expression | ISO | SYNE3 (Homo sapiens) | 6480464 | Silicon Dioxide results in decreased expression of SYNE3 mRNA | CTD | PMID:25351596 | Syne3 | Rat | silver atom | increases expression | ISO | Syne3 (Mus musculus) | 6480464 | Silver results in increased expression of SYNE3 mRNA | CTD | PMID:27131904 | Syne3 | Rat | silver(0) | increases expression | ISO | Syne3 (Mus musculus) | 6480464 | Silver results in increased expression of SYNE3 mRNA | CTD | PMID:27131904 | Syne3 | Rat | sotorasib | multiple interactions | ISO | SYNE3 (Homo sapiens) | 6480464 | [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of SYNE3 mRNA | CTD | PMID:36139627 | Syne3 | Rat | sunitinib | increases expression | ISO | SYNE3 (Homo sapiens) | 6480464 | Sunitinib results in increased expression of SYNE3 mRNA | CTD | PMID:31533062 | Syne3 | Rat | temozolomide | decreases expression | ISO | SYNE3 (Homo sapiens) | 6480464 | Temozolomide results in decreased expression of SYNE3 mRNA | CTD | PMID:31758290 | Syne3 | Rat | trametinib | multiple interactions | ISO | SYNE3 (Homo sapiens) | 6480464 | [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of SYNE3 mRNA | CTD | PMID:36139627 | Syne3 | Rat | triphenyl phosphate | affects expression | ISO | SYNE3 (Homo sapiens) | 6480464 | triphenyl phosphate affects the expression of SYNE3 mRNA | CTD | PMID:37042841 | Syne3 | Rat | urethane | decreases expression | ISO | SYNE3 (Homo sapiens) | 6480464 | Urethane results in decreased expression of SYNE3 mRNA | CTD | PMID:28818685 | Syne3 | Rat | valproic acid | increases methylation | ISO | SYNE3 (Homo sapiens) | 6480464 | Valproic Acid results in increased methylation of SYNE3 gene | CTD | PMID:29154799 | Syne3 | Rat | valproic acid | multiple interactions | ISO | SYNE3 (Homo sapiens) | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SYNE3 mRNA | CTD | PMID:27188386 | Syne3 | Rat | valproic acid | increases expression | ISO | SYNE3 (Homo sapiens) | 6480464 | Valproic Acid results in increased expression of SYNE3 mRNA | CTD | PMID:23179753 more ... | |