Klk1c12 (kallikrein 1-related peptidase C12) - Rat Genome Database

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Gene: Klk1c12 (kallikrein 1-related peptidase C12) Rattus norvegicus
No known orthologs.
Symbol: Klk1c12
Name: kallikrein 1-related peptidase C12
RGD ID: 1303192
Description: Predicted to enable serine-type endopeptidase activity. Predicted to be involved in regulation of systemic arterial blood pressure and zymogen activation. Predicted to be active in secretory granule. Human ortholog(s) of this gene implicated in cardiomyopathy; chronic kidney disease; end stage renal disease; hypertension; and myocardial infarction. Orthologous to human KLK1 (kallikrein 1); INTERACTS WITH bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: glandular kallikrein 12, submandibular/renal; glandular kallikrein-12, submandibular/renal; glandular kallikrein-7, submandibular/renal; kallikrein 1; Klk1; Klk12; LOC687880; LOC690635; RSKG-3; similar to Kallikrein-1 precursor (Tissue kallikrein) (Kidney/pancreas/salivary gland kallikrein); tissue kallikrein
RGD Orthologs
Alliance Genes
More Info homologs ...
Is Marker For: Strains:   SHRSR.SHRSP-(Klk1-Mt1-ps1)/Bbb   SHRSR.SHRSP-(Klk1-D1Mit3)/Bbb   SHRSP.SHRSR-(Klk1-Mt1-ps1)/Bbb   SHRSP.SHRSR-(Klk1-D1Mit3)/Bbb  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2194,378,103 - 94,382,140 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl194,378,054 - 94,382,176 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx199,763,522 - 99,767,559 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01108,236,147 - 108,240,184 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01101,526,623 - 101,530,654 (-)NCBIRnor_WKY
Rnor_6.0199,298,965 - 99,303,048 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl199,299,011 - 99,303,048 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01100,371,040 - 100,375,077 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4194,355,758 - 94,359,795 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1194,433,868 - 94,437,906 (-)NCBI
Celera188,645,697 - 88,649,734 (-)NCBICelera
Cytogenetic Map1q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
bisphenol A  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function


References - curated
# Reference Title Reference Citation
1. Molecular cloning and characterization of two rat renal kallikrein genes. Chen YP, etal., Biochemistry 1988 Sep 20;27(19):7189-96.
2. Early activation of bradykinin B2 receptor aggravates reactive oxygen species generation and renal damage in ischemia/reperfusion injury. Chiang WC, etal., Free Radic Biol Med. 2006 Oct 15;41(8):1304-14. Epub 2006 Jul 15.
3. Differences in substrate and inhibitor sequence specificity of human, mouse and rat tissue kallikreins. Fogaca SE, etal., Biochem J. 2004 Jun 15;380(Pt 3):775-81.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Mechanism of kinin release during experimental acute pancreatitis in rats: evidence for pro- as well as anti-inflammatory roles of oedema formation. Griesbacher T, etal., Br J Pharmacol. 2003 May;139(2):299-308.
6. Regulatory effects of salt diet on renal renin-angiotensin-aldosterone, and kallikrein-kinin systems. Hettinger U, etal., Int Immunopharmacol. 2002 Dec;2(13-14):1975-80.
7. Rat tissue kallikrein releases a kallidin-like peptide from rat low-molecular-weight kininogen. Hilgenfeldt U, etal., Br J Pharmacol. 2005 Dec;146(7):958-63.
8. Relationship between the regulatory region polymorphism of human tissue kallikrein gene and essential hypertension. Hua H, etal., J Hum Hypertens. 2005 Sep;19(9):715-21.
9. Biochemical and immunohistochemical demonstration of tissue kallikrein in the neuronal nuclei of the developing rat brains. Iwadate H, etal., Brain Res. 2000 Apr 28;863(1-2):87-93.
10. Klk1 as one of the genes contributing to hypertension in Dahl salt-sensitive rat. Iwai N, etal., Hypertension 2005 May;45(5):947-53. Epub 2005 Apr 4.
11. Growth-stimulating effect of kallikrein on rat neural stem cells--II. Immunocytochemical analysis and specificity of the enzyme for neural stem cells. Kizuki K, etal., Yakugaku Zasshi. 2007 May;127(5):919-22.
12. Cardiac function and remodeling is attenuated in transgenic rats expressing the human kallikrein-1 gene after myocardial infarction. Koch M, etal., Eur J Pharmacol. 2006 Nov 21;550(1-3):143-8. Epub 2006 Sep 7.
13. Tissue kallikrein protects against pressure overload-induced cardiac hypertrophy through kinin B2 receptor and glycogen synthase kinase-3beta activation. Li HJ, etal., Cardiovasc Res. 2007 Jan 1;73(1):130-42. Epub 2006 Oct 27.
14. Disparate tissue-specific expression of members of the tissue kallikrein multigene family of the rat. MacDonald RJ, etal., J Biol Chem 1996 Jun 7;271(23):13684-90.
15. Tissue kallikrein and bradykinin B2 receptors in the reproductive tract of the male rat. Monsees TK, etal., Andrologia. 2003 Feb;35(1):24-31.
16. Taxon-specific evolution of glandular kallikrein genes and identification of a progenitor of prostate-specific antigen. Olsson AY, etal., Genomics 2004 Jul;84(1):147-56.
17. GOA pipeline RGD automated data pipeline
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. Role of the bradykinin B2 receptor for the local and systemic inflammatory response that follows severe reperfusion injury. Souza DG, etal., Br J Pharmacol. 2003 May;139(1):129-39.
20. Prevention of cardiac fibrosis and left ventricular dysfunction in diabetic cardiomyopathy in rats by transgenic expression of the human tissue kallikrein gene. Tschope C, etal., FASEB J. 2004 May;18(7):828-35.
21. Myocardial expression of rat bradykinin receptors and two tissue kallikrein genes in experimental diabetes. Tschope C, etal., Immunopharmacology. 1999 Oct 15;44(1-2):35-42.
22. Tissue kallikrein reverses insulin resistance and attenuates nephropathy in diabetic rats by activation of phosphatidylinositol 3-kinase/protein kinase B and adenosine 5'-monophosphate-activated protein kinase signaling pathways. Yuan G, etal., Endocrinology. 2007 May;148(5):2016-26. Epub 2007 Feb 1.
Additional References at PubMed
PMID:18090545   PMID:18311071   PMID:19164804   PMID:20345876  



Variants in Klk1c12
12 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:109
Count of miRNA genes:86
Interacting mature miRNAs:89
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)122340647102268831Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)130882023123479925Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
2313051Bss57Bone structure and strength QTL 573.70.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)143284731118944897Rat
2313059Bss55Bone structure and strength QTL 553.20.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313072Bss53Bone structure and strength QTL 534.30.0001tibia length (VT:0004357)tibia length (CMO:0000450)143284731118944897Rat
2313078Bss54Bone structure and strength QTL 543.50.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313094Bss58Bone structure and strength QTL 583.70.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143284731118944897Rat
2313098Bmd70Bone mineral density QTL 703.60.0001tibia mineral mass (VT:1000283)cortical volumetric bone mineral density (CMO:0001730)143284731118944897Rat
2313099Bss56Bone structure and strength QTL 562.40.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143284731118944897Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)148963584144267916Rat
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)14939317294393172Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)15673266898773277Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)156949932101949932Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)157336763151090257Rat
1300121Hrtrt1Heart rate QTL 13.7heart pumping trait (VT:2000009)heart rate (CMO:0000002)165789093115540829Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)166023617118608521Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)177494165122494165Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)177857876122857876Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)177876254106047988Rat
61344Bp29Blood pressure QTL 297.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)178350581123350581Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)178430536123430536Rat
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)178479925123479925Rat
4889494Scort2Serum corticosterone level QTL 24.2blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)180592172125592172Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
2313083Bmd74Bone mineral density QTL 7440.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)182174743118944897Rat
738022Anxrr13Anxiety related response QTL 134.60.00039locomotor behavior trait (VT:0001392)number of 20 x 20 cm floor squares crossed into, out of or within a discrete space in an experimental apparatus (CMO:0001514)183547917128547917Rat
2300324Fetw1Fetal weight QTL 112.10.005fetal growth trait (VT:0004201)fetal body weight (CMO:0002080)185424647100358001Rat
724529Cm16Cardiac mass QTL 162.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)187580395150700247Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)190508614173018436Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)190508614180359386Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)190532338123479925Rat
1300153Bp171Blood pressure QTL 1713.37arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)190664883143200202Rat
2293142Bp314Blood pressure QTL 314arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)192184926137184926Rat
724567Tcas6Tongue tumor susceptibility QTL 66.85tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)192948896144267916Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.01100,372,157 - 100,372,331NCBIRnor5.0
Rnor_5.01101,154,236 - 101,154,356NCBIRnor5.0
Rnor_5.01100,934,189 - 100,934,363NCBIRnor5.0
Rnor_5.01100,934,188 - 100,934,363NCBIRnor5.0
Rnor_5.01100,372,156 - 100,372,331NCBIRnor5.0
Rnor_5.01101,154,235 - 101,154,356NCBIRnor5.0
RGSC_v3.4194,582,077 - 94,582,196UniSTSRGSC3.4
RGSC_v3.4194,582,076 - 94,582,196RGDRGSC3.4
RGSC_v3.4194,356,875 - 94,357,049RGDRGSC3.4
RGSC_v3.4194,356,876 - 94,357,049UniSTSRGSC3.4
RGSC_v3.1194,660,187 - 94,660,307RGD
Celera188,866,843 - 88,866,962UniSTS
Celera188,646,815 - 88,646,988UniSTS
RH 3.4 Map1905.2RGD
RH 3.4 Map1905.2UniSTS
Cytogenetic Map1q22UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

renal system reproductive system
Low 8
Below cutoff 14 1


Reference Sequences
RefSeq Acc Id: ENSRNOT00000025631   ⟹   ENSRNOP00000025631
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl199,299,011 - 99,303,048 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000105362   ⟹   ENSRNOP00000077552
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl194,378,060 - 94,382,176 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000113518   ⟹   ENSRNOP00000092108
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl194,378,054 - 94,380,772 (-)Ensembl
RefSeq Acc Id: NM_001005382   ⟹   NP_001005382
RefSeq Status: VALIDATED
Rat AssemblyChrPosition (strand)Source
mRatBN7.2194,378,103 - 94,382,140 (-)NCBI
Rnor_6.0199,299,011 - 99,303,048 (-)NCBI
Rnor_5.01100,371,040 - 100,375,077 (-)NCBI
RGSC_v3.4194,355,758 - 94,359,795 (-)RGD
Celera188,645,697 - 88,649,734 (-)RGD
RefSeq Acc Id: XM_017588920   ⟹   XP_017444409
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2194,378,103 - 94,382,140 (-)NCBI
Rnor_6.0199,298,965 - 99,303,048 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001005382 (Get FASTA)   NCBI Sequence Viewer  
  XP_017444409 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA51640 (Get FASTA)   NCBI Sequence Viewer  
  P36376 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001005382   ⟸   NM_001005382
- Peptide Label: precursor
- UniProtKB: F1LNH4 (UniProtKB/TrEMBL),   A0A8I5Y6G6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017444409   ⟸   XM_017588920
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000025631   ⟸   ENSRNOT00000025631
RefSeq Acc Id: ENSRNOP00000077552   ⟸   ENSRNOT00000105362
RefSeq Acc Id: ENSRNOP00000092108   ⟸   ENSRNOT00000113518
Protein Domains
Peptidase S1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P36376-F1-model_v2 AlphaFold P36376 1-259 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1303192 AgrOrtholog
BioCyc Gene G2FUF-59815 BioCyc
Ensembl Genes ENSRNOG00000047662 Ensembl
  ENSRNOG00000069309 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000077552 ENTREZGENE
  ENSRNOP00000077552.1 UniProtKB/TrEMBL
  ENSRNOP00000092108.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000105362 ENTREZGENE
  ENSRNOT00000105362.1 UniProtKB/TrEMBL
  ENSRNOT00000113518.1 UniProtKB/TrEMBL
Gene3D-CATH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Peptidase_S1_PA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S1_PA_chymotrypsin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S1A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Trypsin_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Trypsin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Klk1c12 PhenoGen
  TRYPSIN_HIS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART Tryp_SPc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50494 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KLK12_RAT UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Klk1c12  kallikrein 1-related peptidase C12  LOC687880  similar to Kallikrein-1 precursor (Tissue kallikrein) (Kidney/pancreas/salivary gland kallikrein)  Data Merged 737654 PROVISIONAL
2015-07-29 LOC687880  similar to Kallikrein-1 precursor (Tissue kallikrein) (Kidney/pancreas/salivary gland kallikrein)  LOC690635  similar to Kallikrein-1 precursor (Tissue kallikrein) (Kidney/pancreas/salivary gland kallikrein)  Data Merged 737654 PROVISIONAL
2011-06-29 Klk1c12  kallikrein 1-related peptidase C12  Klk1  kallikrein 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2007-10-01 Klk1  kallikrein 1  Klk12  glandular kallikrein 12, submandibular/renal  Symbol and Name updated to reflect Human and Mouse nomenclature 1299863 APPROVED
2006-11-20 LOC687880  similar to Kallikrein-1 precursor (Tissue kallikrein) (Kidney/pancreas/salivary gland kallikrein)      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-20 LOC690635  similar to Kallikrein-1 precursor (Tissue kallikrein) (Kidney/pancreas/salivary gland kallikrein)      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-01-17 Klk12  succinate receptor 1  KLK12  glandular kallikrein 12, submandibular/renal  Symbol updated 1299863 APPROVED