Phactr1 (phosphatase and actin regulator 1) - Rat Genome Database

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Gene: Phactr1 (phosphatase and actin regulator 1) Rattus norvegicus
Analyze
Symbol: Phactr1
Name: phosphatase and actin regulator 1
RGD ID: 1303187
Description: Enables protein phosphatase 1 binding activity. Involved in cellular response to mechanical stimulus; positive regulation of gene expression; and regulation of phosphorylation. Located in cytoplasm and nucleus. Biomarker of myocardial infarction. Human ortholog(s) of this gene implicated in artery disease (multiple) and brain disease (multiple). Orthologous to human PHACTR1 (phosphatase and actin regulator 1); INTERACTS WITH 17beta-estradiol 3-benzoate; 2,4-dinitrotoluene; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: MGC112561
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81721,769,006 - 22,246,227 (-)NCBIGRCr8
mRatBN7.21721,560,364 - 22,040,166 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1721,562,721 - 22,039,831 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1721,452,066 - 21,925,681 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01723,055,730 - 23,529,379 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01721,379,161 - 21,852,788 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01723,245,423 - 23,761,207 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01725,209,368 - 25,713,282 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41727,393,237 - 27,884,127 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11727,395,233 - 27,885,918 (-)NCBI
Celera1721,259,994 - 21,732,655 (-)NCBICelera
Cytogenetic Map17p14-p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IDA)
cytosol  (IEA,ISO,ISS)
nucleus  (IDA,IEA,ISO,ISS)
synapse  (IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phactrs 1-4: A family of protein phosphatase 1 and actin regulatory proteins. Allen PB, etal., Proc Natl Acad Sci U S A 2004 May 4;101(18):7187-92. Epub 2004 Apr 23.
2. Myocardial Infarction-Associated SNP at 6p24 Interferes With MEF2 Binding and Associates With PHACTR1 Expression Levels in Human Coronary Arteries. Beaudoin M, etal., Arterioscler Thromb Vasc Biol. 2015 Jun;35(6):1472-9. doi: 10.1161/ATVBAHA.115.305534. Epub 2015 Apr 2.
3. Genetic heritability of ischemic stroke and the contribution of previously reported candidate gene and genomewide associations. Bevan S, etal., Stroke. 2012 Dec;43(12):3161-7. doi: 10.1161/STROKEAHA.112.665760. Epub 2012 Oct 4.
4. PHACTR1 gene polymorphism with the risk of coronary artery disease in Chinese Han population. Chen L, etal., Postgrad Med J. 2019 Feb;95(1120):67-71. doi: 10.1136/postgradmedj-2018-136298. Epub 2019 Feb 18.
5. National French registry of spontaneous coronary artery dissections: prevalence of fibromuscular dysplasia and genetic analyses. Combaret N, etal., EuroIntervention. 2021 Aug 27;17(6):508-515. doi: 10.4244/EIJ-D-20-01046.
6. Common variation in PHACTR1 is associated with susceptibility to cervical artery dissection. Debette S, etal., Nat Genet. 2015 Jan;47(1):78-83. doi: 10.1038/ng.3154. Epub 2014 Nov 24.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Investigating Coronary Artery Disease methylome through targeted bisulfite sequencing. Ghose S, etal., Gene. 2019 Dec 30;721:144107. doi: 10.1016/j.gene.2019.144107. Epub 2019 Sep 6.
9. Differential expression of PHACTR1 in atheromatous versus normal carotid artery tissue. Green IE, etal., J Clin Neurosci. 2020 Apr;74:265-267. doi: 10.1016/j.jocn.2020.01.018. Epub 2020 Jan 21.
10. Genome-wide association study in a Lebanese cohort confirms PHACTR1 as a major determinant of coronary artery stenosis. Hager J, etal., PLoS One. 2012;7(6):e38663. doi: 10.1371/journal.pone.0038663. Epub 2012 Jun 20.
11. Inhibiting phosphatase and actin regulator 1 expression is neuroprotective in the context of traumatic brain injury. Jing Y, etal., Neural Regen Res. 2023 Jul;18(7):1578-1583. doi: 10.4103/1673-5374.357904.
12. The Early-Onset Myocardial Infarction Associated PHACTR1 Gene Regulates Skeletal and Cardiac Alpha-Actin Gene Expression. Kelloniemi A, etal., PLoS One. 2015 Jun 22;10(6):e0130502. doi: 10.1371/journal.pone.0130502. eCollection 2015.
13. PHACTR1 Is a Genetic Susceptibility Locus for Fibromuscular Dysplasia Supporting Its Complex Genetic Pattern of Inheritance. Kiando SR, etal., PLoS Genet. 2016 Oct 28;12(10):e1006367. doi: 10.1371/journal.pgen.1006367. eCollection 2016 Oct.
14. PHACTR1 haplotypes are associated with carotid plaque presence and affect PHACTR1 mRNA expression in carotid plaque tissue. Kuveljic J, etal., Gene. 2019 Aug 20;710:273-278. doi: 10.1016/j.gene.2019.06.020. Epub 2019 Jun 12.
15. Association of PHACTR1 intronic variants with the first myocardial infarction and their effect on PHACTR1 mRNA expression in PBMCs. Kuveljic J, etal., Gene. 2021 Apr 5;775:145428. doi: 10.1016/j.gene.2021.145428. Epub 2021 Jan 16.
16. Genetic deficiency of Phactr1 promotes atherosclerosis development via facilitating M1 macrophage polarization and foam cell formation. Li T, etal., Clin Sci (Lond). 2020 Sep 18;134(17):2353-2368. doi: 10.1042/CS20191241.
17. The alleles of AGT and HIF1A gene affect the risk of hypertension in plateau residents. Li Z, etal., Exp Biol Med (Maywood). 2022 Feb;247(3):237-245. doi: 10.1177/15353702211055838. Epub 2021 Nov 10.
18. Multiethnic Genome-Wide Association Study of Subclinical Atherosclerosis in Individuals With Type 2 Diabetes. Lu Y, etal., Circ Genom Precis Med. 2021 Aug;14(4):e003258. doi: 10.1161/CIRCGEN.120.003258. Epub 2021 Jul 9.
19. PHACTR1, a coronary artery disease risk gene, mediates endothelial dysfunction. Ma X, etal., Front Immunol. 2022 Aug 25;13:958677. doi: 10.3389/fimmu.2022.958677. eCollection 2022.
20. Increased Risk of CHD in the Presence of rs7865618 (A allele): Tehran Lipid and Glucose Study. Matoo S, etal., Arch Iran Med. 2017 Mar;20(3):153-157.
21. Association of six genetic variants with myocardial infarction. Matsuoka R, etal., Int J Mol Med. 2015 May;35(5):1451-9. doi: 10.3892/ijmm.2015.2115. Epub 2015 Feb 27.
22. Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants. Myocardial Infarction Genetics Consortium, etal., Nat Genet. 2009 Mar;41(3):334-41. doi: 10.1038/ng.327. Epub 2009 Feb 8.
23. PHACTR1 genotype predicts coronary artery disease in patients with familial hypercholesterolemia. Paquette M, etal., J Clin Lipidol. 2018 Jul-Aug;12(4):966-971. doi: 10.1016/j.jacl.2018.04.012. Epub 2018 Apr 30.
24. Risk loci for coronary artery calcification replicated at 9p21 and 6q24 in the Heinz Nixdorf Recall Study. Pechlivanis S, etal., BMC Med Genet. 2013 Feb 8;14:23. doi: 10.1186/1471-2350-14-23.
25. PHACTR1 Gene Polymorphism Is Associated with Increased Risk of Developing Premature Coronary Artery Disease in Mexican Population. Pérez-Hernández N, etal., Int J Environ Res Public Health. 2016 Aug 9;13(8):803. doi: 10.3390/ijerph13080803.
26. Genetic susceptibility to coronary heart disease in type 2 diabetes: 3 independent studies. Qi L, etal., J Am Coll Cardiol. 2011 Dec 13;58(25):2675-82. doi: 10.1016/j.jacc.2011.08.054.
27. Genetic and environmental risk factors for atherosclerosis regulate transcription of phosphatase and actin regulating gene PHACTR1. Reschen ME, etal., Atherosclerosis. 2016 Jul;250:95-105. doi: 10.1016/j.atherosclerosis.2016.04.025. Epub 2016 May 2.
28. GOA pipeline RGD automated data pipeline
29. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
30. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
31. Chromosome 1q21.2 and additional loci influence risk of spontaneous coronary artery dissection and myocardial infarction. Saw J, etal., Nat Commun. 2020 Sep 4;11(1):4432. doi: 10.1038/s41467-020-17558-x.
32. The rs12526453 Polymorphism in an Intron of the PHACTR1 Gene and Its Association with 5-Year Mortality of Patients with Myocardial Infarction. Szpakowicz A, etal., PLoS One. 2015 Jun 18;10(6):e0129820. doi: 10.1371/journal.pone.0129820. eCollection 2015.
33. Identification of Susceptibility Loci for Spontaneous Coronary Artery Dissection. Turley TN, etal., JAMA Cardiol. 2020 Aug 1;5(8):929-938. doi: 10.1001/jamacardio.2020.0872.
34. Genome-wide association study of coronary and aortic calcification implicates risk loci for coronary artery disease and myocardial infarction. van Setten J, etal., Atherosclerosis. 2013 Jun;228(2):400-5. doi: 10.1016/j.atherosclerosis.2013.02.039. Epub 2013 Mar 13.
35. Common genetic variants and subclinical atherosclerosis: The Multi-Ethnic Study of Atherosclerosis (MESA). Vargas JD, etal., Atherosclerosis. 2016 Feb;245:230-6. doi: 10.1016/j.atherosclerosis.2015.11.034. Epub 2015 Dec 8.
36. Genetic Study of PHACTR1 and Fibromuscular Dysplasia, Meta-Analysis and Effects on Clinical Features of Patients: The ARCADIA-POL Study. Warchol-Celinska E, etal., Hypertension. 2020 Jul;76(1):e4-e7. doi: 10.1161/HYPERTENSIONAHA.120.14793. Epub 2020 Jun 1.
37. Genetic analysis for a shared biological basis between migraine and coronary artery disease. Winsvold BS, etal., Neurol Genet. 2015 Jul 2;1(1):e10. doi: 10.1212/NXG.0000000000000010. eCollection 2015 Jun.
38. Shared genetic risk between migraine and coronary artery disease: A genome-wide analysis of common variants. Winsvold BS, etal., PLoS One. 2017 Sep 28;12(9):e0185663. doi: 10.1371/journal.pone.0185663. eCollection 2017.
39. PHACTR1 is associated with disease progression in Chinese Moyamoya disease. Yang Y, etal., PeerJ. 2020 May 5;8:e8841. doi: 10.7717/peerj.8841. eCollection 2020.
40. PHACTR1 and SLC22A3 gene polymorphisms are associated with reduced coronary artery disease risk in the male Chinese Han population. Zhao Q, etal., Oncotarget. 2017 Jan 3;8(1):658-663. doi: 10.18632/oncotarget.13506.
Additional References at PubMed
PMID:12477932   PMID:15489334   PMID:22976292   PMID:30053369   PMID:30256902  


Genomics

Comparative Map Data
Phactr1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81721,769,006 - 22,246,227 (-)NCBIGRCr8
mRatBN7.21721,560,364 - 22,040,166 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1721,562,721 - 22,039,831 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1721,452,066 - 21,925,681 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01723,055,730 - 23,529,379 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01721,379,161 - 21,852,788 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01723,245,423 - 23,761,207 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01725,209,368 - 25,713,282 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41727,393,237 - 27,884,127 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11727,395,233 - 27,885,918 (-)NCBI
Celera1721,259,994 - 21,732,655 (-)NCBICelera
Cytogenetic Map17p14-p12NCBI
PHACTR1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38612,716,767 - 13,287,837 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl612,716,312 - 13,290,446 (+)EnsemblGRCh38hg38GRCh38
GRCh37612,716,999 - 13,288,069 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36612,825,819 - 13,395,507 (+)NCBINCBI36Build 36hg18NCBI36
Celera613,945,879 - 14,520,501 (+)NCBICelera
Cytogenetic Map6p24.1NCBI
HuRef612,649,580 - 13,225,071 (+)NCBIHuRef
CHM1_1612,719,328 - 13,290,404 (+)NCBICHM1_1
T2T-CHM13v2.0612,585,196 - 13,161,093 (+)NCBIT2T-CHM13v2.0
Phactr1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391342,833,909 - 43,292,002 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1342,834,099 - 43,292,002 (+)EnsemblGRCm39 Ensembl
GRCm381342,680,374 - 43,138,526 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1342,680,623 - 43,138,526 (+)EnsemblGRCm38mm10GRCm38
MGSCv371342,775,992 - 43,233,895 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361342,691,595 - 43,149,498 (+)NCBIMGSCv36mm8
Celera1343,759,051 - 44,223,388 (+)NCBICelera
Cytogenetic Map13A4NCBI
cM Map1321.05NCBI
Phactr1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554651,395,088 - 1,913,847 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554651,395,418 - 1,915,820 (-)NCBIChiLan1.0ChiLan1.0
PHACTR1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2527,369,901 - 27,944,831 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1623,359,830 - 23,934,840 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0612,560,862 - 13,136,126 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1612,920,920 - 13,508,965 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl612,922,871 - 13,505,609 (+)Ensemblpanpan1.1panPan2
PHACTR1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13512,233,152 - 12,745,031 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3512,491,067 - 12,741,754 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3512,140,823 - 12,694,920 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03512,289,444 - 12,843,408 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3512,291,040 - 12,844,113 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13512,116,414 - 12,670,075 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03512,167,394 - 12,723,499 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03513,491,510 - 14,046,540 (+)NCBIUU_Cfam_GSD_1.0
Phactr1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494611,773,444 - 12,269,374 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493653442,433 - 536,171 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493653442,354 - 323,735 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PHACTR1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl79,105,874 - 9,666,881 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.179,105,422 - 9,666,886 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.279,692,832 - 9,955,704 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PHACTR1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11758,859,456 - 59,440,969 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1758,862,828 - 59,133,298 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604412,759,821 - 13,333,695 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Phactr1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475612,934,212 - 13,447,326 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475612,935,048 - 13,449,312 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Phactr1
5284 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:75
Count of miRNA genes:61
Interacting mature miRNAs:64
Transcripts:ENSRNOT00000046523
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9590316Scort21Serum corticosterone level QTL 214.750.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17122871563Rat
10401807Kidm52Kidney mass QTL 52kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)17131701463Rat
70184BpQTLcluster14Blood pressure QTL cluster 143.38arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)17131990913Rat
631207Niddm41Non-insulin dependent diabetes mellitus QTL 41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)17137830672Rat
1354658Spl8Serum phospholipid level QTL 83.8blood VLDL phospholipid amount (VT:0010507)blood very low density lipoprotein phospholipid level (CMO:0001571)17160781592Rat
1354581Bp247Blood pressure QTL 2474.5arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)17169599340Rat
1354662Rf49Renal function QTL 492.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)17169599340Rat
1641902Colcr7Colorectal carcinoma resistance QTL 73.350.0044intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)17211514921881669Rat
1300123Bp194Blood pressure QTL 1942.82arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)17211514934551001Rat
631499Stl1Serum triglyceride level QTL 13.6blood triglyceride amount (VT:0002644)blood triglyceride level (CMO:0000118)17327139827389946Rat
1354613Kidm14Kidney mass QTL 146.2kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)17429913035837242Rat
1354596Bw32Body weight QTL 324.5body mass (VT:0001259)body weight (CMO:0000012)17429913060781592Rat
1354630Cm34Cardiac mass QTL 348.7heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)17429913069599340Rat
1354638Insul1Insulin level QTL 14.8blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)17429913069599340Rat
1354651Lmblg2Limb length QTL 26tibia length (VT:0004357)tibia length (CMO:0000450)17429913069599340Rat
2293648Bmd31Bone mineral density QTL 314.50.0001femur size trait (VT:1000369)femoral neck cortical cross-sectional area (CMO:0001702)17435448727028127Rat
2293664Bmd28Bone mineral density QTL 285.10.0001femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)17435448727028127Rat
2303627Vencon8Ventilatory control QTL 80.001respiration trait (VT:0001943)tidal volume (CMO:0000222)17452803849528038Rat
10054088Scort28Serum corticosterone level QTL 282.040.0102blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17452803849528038Rat
2303561Bw91Body weight QTL 912body mass (VT:0001259)body weight (CMO:0000012)17886846253868462Rat
1582199Insul5Insulin level QTL 53.40.0119blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)17920136523653323Rat
1582208Kidm32Kidney mass QTL 323.90.0018kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)17920136523653323Rat
1582224Epfw4Epididymal fat weight QTL 43.50.0058epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)17920136523653323Rat
1582225Bw67Body weight QTL 676.20.0001body mass (VT:0001259)body weight (CMO:0000012)17920136523653323Rat
1582226Bw64Body weight QTL 644.20.0017body mass (VT:0001259)body weight (CMO:0000012)17920136523653323Rat
1582241Bw70Body weight QTL 704.60.0003body mass (VT:0001259)body weight (CMO:0000012)17920136523653323Rat
1582245Bw73Body weight QTL 734.60.0004body mass (VT:0001259)body weight (CMO:0000012)17920136523653323Rat
1582258Bw76Body weight QTL 764.60.0005body mass (VT:0001259)body weight (CMO:0000012)17920136523653323Rat
2300002Iddm36Insulin dependent diabetes mellitus QTL 361.98blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)17999128640540197Rat
1549900Iddm20Insulin dependent diabetes mellitus QTL 203.7pancreas integrity trait (VT:0010560)percentage of study population developing diabetes mellitus during a period of time (CMO:0001114)171398677321975515Rat
1331720Rf43Renal function QTL 432.881kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)171533061323017269Rat
1331765Hrtrt15Heart rate QTL 154.094heart pumping trait (VT:2000009)heart rate (CMO:0000002)171533061355836425Rat
1354640Scl32Serum cholesterol level QTL 325.4blood HDL cholesterol amount (VT:0000184)blood high density lipoprotein cholesterol level (CMO:0000052)171578159260781592Rat
1354659Scl68Serum cholesterol level QTL 683.9blood VLDL cholesterol amount (VT:0005144)blood very low density lipoprotein cholesterol level (CMO:0000648)171578159260781592Rat
7394837Memor18Memory QTL 18exploratory behavior trait (VT:0010471)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)171864018263640182Rat
1354628Stl13Serum triglyceride level QTL 133.8blood triglyceride amount (VT:0002644)blood triglyceride level (CMO:0000118)172129303960781592Rat

Markers in Region
D17Rat8  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21721,782,841 - 21,783,009 (-)MAPPERmRatBN7.2
Rnor_6.01723,522,321 - 23,522,488NCBIRnor6.0
Rnor_5.01725,486,196 - 25,486,363UniSTSRnor5.0
RGSC_v3.41727,618,789 - 27,619,178RGDRGSC3.4
RGSC_v3.41727,619,001 - 27,619,168UniSTSRGSC3.4
RGSC_v3.11727,621,842 - 27,622,009RGD
RH 3.4 Map17268.8UniSTS
RH 3.4 Map17268.8RGD
RH 2.0 Map17185.2RGD
SHRSP x BN Map1713.92RGD
FHH x ACI Map1719.0399RGD
Cytogenetic Map17p12UniSTS
D17Rat59  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21721,881,508 - 21,881,669 (-)MAPPERmRatBN7.2
Rnor_6.01723,422,220 - 23,422,380NCBIRnor6.0
Rnor_5.01725,386,725 - 25,386,885UniSTSRnor5.0
RGSC_v3.41727,724,645 - 27,724,805UniSTSRGSC3.4
RGSC_v3.41727,724,644 - 27,724,805RGDRGSC3.4
RGSC_v3.11727,727,486 - 27,727,646RGD
Celera1721,577,874 - 21,578,034UniSTS
RH 3.4 Map17272.4RGD
RH 3.4 Map17272.4UniSTS
RH 2.0 Map17189.1RGD
SHRSP x BN Map1713.88RGD
FHH x ACI Map1718.9999RGD
Cytogenetic Map17p12UniSTS
D17Rat115  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21721,975,268 - 21,975,515 (-)MAPPERmRatBN7.2
Rnor_6.01723,316,451 - 23,316,697NCBIRnor6.0
Rnor_5.01725,279,973 - 25,280,219UniSTSRnor5.0
RGSC_v3.41727,818,835 - 27,819,082RGDRGSC3.4
RGSC_v3.41727,818,836 - 27,819,082UniSTSRGSC3.4
RGSC_v3.11727,821,652 - 27,822,133RGD
Celera1721,669,786 - 21,670,010UniSTS
SHRSP x BN Map1713.88RGD
SHRSP x BN Map1713.88UniSTS
Cytogenetic Map17p12UniSTS
BF412854  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21721,848,806 - 21,848,976 (-)MAPPERmRatBN7.2
Rnor_6.01723,454,899 - 23,455,068NCBIRnor6.0
Rnor_5.01725,419,397 - 25,419,566UniSTSRnor5.0
RGSC_v3.41727,691,323 - 27,691,492UniSTSRGSC3.4
Celera1721,545,223 - 21,545,393UniSTS
RH 3.4 Map17272.5UniSTS
Cytogenetic Map17p12UniSTS
BE119850  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21721,583,739 - 21,583,890 (-)MAPPERmRatBN7.2
Rnor_6.01723,740,888 - 23,741,038NCBIRnor6.0
Rnor_5.01725,692,963 - 25,693,113UniSTSRnor5.0
Celera1721,280,158 - 21,280,308UniSTS
RH 3.4 Map17266.0UniSTS
Cytogenetic Map17p12UniSTS
RH144105  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21721,880,220 - 21,880,369 (-)MAPPERmRatBN7.2
Rnor_6.01723,423,520 - 23,423,668NCBIRnor6.0
Rnor_5.01725,388,025 - 25,388,173UniSTSRnor5.0
RGSC_v3.41727,723,357 - 27,723,505UniSTSRGSC3.4
Celera1721,576,586 - 21,576,734UniSTS
RH 3.4 Map17272.5UniSTS
Cytogenetic Map17p12UniSTS
AU048286  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21721,687,465 - 21,687,582 (-)MAPPERmRatBN7.2
Rnor_6.01723,622,575 - 23,622,691NCBIRnor6.0
Rnor_5.01725,579,624 - 25,579,740UniSTSRnor5.0
RGSC_v3.41727,512,883 - 27,512,999UniSTSRGSC3.4
Celera1721,384,351 - 21,384,467UniSTS
Cytogenetic Map17p12UniSTS
RH138279  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21721,972,786 - 21,972,955 (-)MAPPERmRatBN7.2
Rnor_6.01723,319,011 - 23,319,179NCBIRnor6.0
Rnor_5.01725,282,533 - 25,282,701UniSTSRnor5.0
RGSC_v3.41727,816,354 - 27,816,522UniSTSRGSC3.4
Celera1721,667,305 - 21,667,473UniSTS
RH 3.4 Map17270.5UniSTS
Cytogenetic Map17p12UniSTS
AI171242  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21721,548,163 - 21,548,274 (-)MAPPERmRatBN7.2
Rnor_6.01723,775,075 - 23,775,185NCBIRnor6.0
Rnor_6.01723,713,164 - 23,713,274NCBIRnor6.0
Rnor_5.01725,727,150 - 25,727,260UniSTSRnor5.0
Rnor_5.01725,667,333 - 25,667,443UniSTSRnor5.0
RGSC_v3.41727,377,838 - 27,377,948UniSTSRGSC3.4
Celera1721,244,601 - 21,244,711UniSTS
RH 3.4 Map17267.9UniSTS
Cytogenetic Map17p12UniSTS
AU048960  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21721,875,337 - 21,875,538 (-)MAPPERmRatBN7.2
Rnor_6.01723,428,351 - 23,428,551NCBIRnor6.0
Rnor_5.01725,392,856 - 25,393,056UniSTSRnor5.0
RGSC_v3.41727,718,474 - 27,718,674UniSTSRGSC3.4
Celera1721,571,702 - 21,571,902UniSTS
Cytogenetic Map17p12UniSTS
Satt227  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21721,581,286 - 21,582,212 (-)MAPPERmRatBN7.2
Rnor_6.01723,742,566 - 23,743,491NCBIRnor6.0
Rnor_5.01725,694,641 - 25,695,566UniSTSRnor5.0
RGSC_v3.41727,409,825 - 27,410,751UniSTSRGSC3.4
Celera1721,277,705 - 21,278,630UniSTS
Cytogenetic Map17p12UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_214457 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039095676 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039095677 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039095678 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039095679 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039095680 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039095681 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039095683 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039095684 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039095685 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276381 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276382 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276383 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276384 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AY494977 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC098634 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000017 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSRNOT00000046523   ⟹   ENSRNOP00000043053
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1721,562,721 - 21,780,363 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000106668   ⟹   ENSRNOP00000077447
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1721,562,721 - 22,039,831 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000107421   ⟹   ENSRNOP00000078261
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1721,562,721 - 21,797,515 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000110352   ⟹   ENSRNOP00000097958
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1721,562,721 - 22,039,831 (-)Ensembl
RefSeq Acc Id: NM_214457   ⟹   NP_999622
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81721,769,506 - 22,245,136 (-)NCBI
mRatBN7.21721,563,565 - 22,039,240 (-)NCBI
Rnor_6.01723,245,423 - 23,761,207 (+)NCBI
Rnor_5.01725,209,368 - 25,713,282 (+)NCBI
RGSC_v3.41727,393,237 - 27,884,127 (-)RGD
Celera1721,259,994 - 21,732,655 (-)RGD
Sequence:
RefSeq Acc Id: XM_039095676   ⟹   XP_038951604
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81721,769,006 - 22,245,176 (-)NCBI
mRatBN7.21721,560,364 - 22,039,264 (-)NCBI
RefSeq Acc Id: XM_039095677   ⟹   XP_038951605
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81721,769,006 - 22,246,227 (-)NCBI
mRatBN7.21721,560,364 - 22,040,166 (-)NCBI
RefSeq Acc Id: XM_039095678   ⟹   XP_038951606
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81721,769,006 - 22,244,667 (-)NCBI
mRatBN7.21721,560,364 - 22,038,785 (-)NCBI
RefSeq Acc Id: XM_039095679   ⟹   XP_038951607
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81721,769,006 - 22,003,421 (-)NCBI
mRatBN7.21721,560,364 - 21,797,544 (-)NCBI
RefSeq Acc Id: XM_039095680   ⟹   XP_038951608
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81721,769,006 - 21,986,905 (-)NCBI
mRatBN7.21721,560,364 - 21,781,430 (-)NCBI
RefSeq Acc Id: XM_039095681   ⟹   XP_038951609
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81721,769,006 - 22,244,729 (-)NCBI
mRatBN7.21721,560,364 - 22,038,774 (-)NCBI
RefSeq Acc Id: XM_039095683   ⟹   XP_038951611
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81721,769,006 - 22,054,026 (-)NCBI
mRatBN7.21721,560,364 - 21,848,288 (-)NCBI
RefSeq Acc Id: XM_039095684   ⟹   XP_038951612
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81721,769,006 - 21,975,202 (-)NCBI
mRatBN7.21721,560,364 - 21,769,291 (-)NCBI
RefSeq Acc Id: XM_039095685   ⟹   XP_038951613
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81721,769,006 - 21,986,463 (-)NCBI
mRatBN7.21721,560,364 - 21,781,000 (-)NCBI
RefSeq Acc Id: XM_063276381   ⟹   XP_063132451
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81721,769,006 - 22,245,416 (-)NCBI
RefSeq Acc Id: XM_063276382   ⟹   XP_063132452
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81721,769,006 - 22,246,062 (-)NCBI
RefSeq Acc Id: XM_063276383   ⟹   XP_063132453
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81721,769,006 - 22,003,459 (-)NCBI
RefSeq Acc Id: XM_063276384   ⟹   XP_063132454
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81721,769,006 - 22,054,178 (-)NCBI
RefSeq Acc Id: NP_999622   ⟸   NM_214457
- UniProtKB: A0A8I6ATP4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_038951605   ⟸   XM_039095677
- Peptide Label: isoform X1
- UniProtKB: A0A8I5XW51 (UniProtKB/TrEMBL),   A6J754 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038951604   ⟸   XM_039095676
- Peptide Label: isoform X1
- UniProtKB: A0A8I5XW51 (UniProtKB/TrEMBL),   A6J754 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038951606   ⟸   XM_039095678
- Peptide Label: isoform X1
- UniProtKB: A0A8I5XW51 (UniProtKB/TrEMBL),   A6J754 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038951609   ⟸   XM_039095681
- Peptide Label: isoform X4
- UniProtKB: A0A8I6ATP4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038951611   ⟸   XM_039095683
- Peptide Label: isoform X6
RefSeq Acc Id: XP_038951607   ⟸   XM_039095679
- Peptide Label: isoform X2
- UniProtKB: A0A8I5ZKJ8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038951608   ⟸   XM_039095680
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038951613   ⟸   XM_039095685
- Peptide Label: isoform X7
- UniProtKB: F1LNB2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038951612   ⟸   XM_039095684
- Peptide Label: isoform X6
RefSeq Acc Id: ENSRNOP00000043053   ⟸   ENSRNOT00000046523
RefSeq Acc Id: ENSRNOP00000097958   ⟸   ENSRNOT00000110352
RefSeq Acc Id: ENSRNOP00000077447   ⟸   ENSRNOT00000106668
RefSeq Acc Id: ENSRNOP00000078261   ⟸   ENSRNOT00000107421
RefSeq Acc Id: XP_063132452   ⟸   XM_063276382
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063132451   ⟸   XM_063276381
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063132454   ⟸   XM_063276384
- Peptide Label: isoform X8
RefSeq Acc Id: XP_063132453   ⟸   XM_063276383
- Peptide Label: isoform X5

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1LNB2-F1-model_v2 AlphaFold F1LNB2 1-415 view protein structure
AF-P62024-F1-model_v2 AlphaFold P62024 1-580 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1303187 AgrOrtholog
BioCyc Gene G2FUF-9791 BioCyc
Ensembl Genes ENSRNOG00000014264 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOG00055007606 UniProtKB/Swiss-Prot
  ENSRNOG00060009910 UniProtKB/Swiss-Prot
  ENSRNOG00065008419 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000046523.5 UniProtKB/TrEMBL
  ENSRNOT00000106668.1 UniProtKB/TrEMBL
  ENSRNOT00000107421.1 UniProtKB/TrEMBL
  ENSRNOT00000110352 ENTREZGENE
  ENSRNOT00000110352.1 UniProtKB/TrEMBL
  ENSRNOT00055012740 UniProtKB/Swiss-Prot
  ENSRNOT00060016756 UniProtKB/Swiss-Prot
  ENSRNOT00065013348 UniProtKB/Swiss-Prot
Gene3D-CATH 6.10.140.1750 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  6.10.140.2130 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7317963 IMAGE-MGC_LOAD
InterPro RPEL_repeat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:306844 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:112561 IMAGE-MGC_LOAD
NCBI Gene 306844 ENTREZGENE
PANTHER PHOSPHATASE AND ACTIN REGULATOR PHACTR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR12751:SF6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam RPEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Phactr1 PhenoGen
PROSITE RPEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000014264 RatGTEx
  ENSRNOG00055007606 RatGTEx
  ENSRNOG00060009910 RatGTEx
  ENSRNOG00065008419 RatGTEx
SMART RPEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5XW51 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZKJ8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6ATP4 ENTREZGENE, UniProtKB/TrEMBL
  A6J754 ENTREZGENE, UniProtKB/TrEMBL
  F1LNB2 ENTREZGENE, UniProtKB/TrEMBL
  P62024 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q4KMC2 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-07-14 Phactr1  phosphatase and actin regulator 1      Symbol and Name status set to provisional 70820 PROVISIONAL