Ltb (lymphotoxin beta) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Ltb (lymphotoxin beta) Rattus norvegicus
Analyze
Symbol: Ltb
Name: lymphotoxin beta
RGD ID: 1303162
Description: Predicted to enable cytokine activity. Predicted to be involved in cell surface receptor signaling pathway; positive regulation of interleukin-12 production; and positive regulation of signal transduction. Predicted to act upstream of or within gene expression; lymph node development; and skin development. Predicted to be located in membrane. Predicted to be active in extracellular space. Orthologous to human LTB (lymphotoxin beta); PARTICIPATES IN cytokine mediated signaling pathway; rheumatoid arthritis pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC103694381; lymphotoxin B; lymphotoxin beta (TNF superfamily, member 3); lymphotoxin-beta; MGC108924
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8203,632,209 - 3,634,054 (-)NCBIGRCr8
mRatBN7.2203,627,536 - 3,629,381 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl203,627,537 - 3,629,381 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx204,327,296 - 4,329,142 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0203,689,354 - 3,691,200 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0204,226,971 - 4,228,817 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0205,184,631 - 5,186,476 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl205,184,515 - 5,186,503 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl204,861,335 - 4,863,198 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0206,941,753 - 6,943,598 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4203,666,524 - 3,668,369 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1203,666,751 - 3,668,596 (-)NCBI
Celera204,396,109 - 4,397,954 (+)NCBICelera
Cytogenetic Map20p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (EXP)
1-nitropyrene  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-butoxyethanol  (ISO)
2-naphthylamine  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3-Nitrofluoranthene  (ISO)
4,4'-diaminodiphenylmethane  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-amino-2,6-dinitrotoluene  (EXP)
4-hydroxynon-2-enal  (ISO)
5'-S-methyl-5'-thioadenosine  (ISO)
6-propyl-2-thiouracil  (EXP)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
antirheumatic drug  (ISO)
aripiprazole  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
asperentin  (ISO)
benzalkonium chloride  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
beta-naphthoflavone  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
Brevianamide A  (ISO)
buta-1,3-diene  (ISO)
cadmium dichloride  (EXP,ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
chloroprene  (ISO)
chloroquine  (ISO)
cisplatin  (ISO)
clorgyline  (ISO)
curcumin  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibenzo[a,l]pyrene  (ISO)
Dibutyl phosphate  (ISO)
dimethylarsinic acid  (ISO)
dioxygen  (ISO)
diquat  (ISO)
disodium selenite  (ISO)
diuron  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP)
ethylparaben  (ISO)
fentanyl  (EXP)
fumonisin B1  (ISO)
furan  (EXP)
furosemide  (EXP)
gadolinium trichloride  (ISO)
glafenine  (EXP)
hydrogen peroxide  (ISO)
leflunomide  (ISO)
lipopolysaccharide  (ISO)
methylarsonic acid  (ISO)
Muraglitazar  (EXP)
mycophenolic acid  (ISO)
mycotoxin  (ISO)
N-methyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (EXP)
neoechinulin A  (ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
nicotine  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
PF-3758309  (ISO)
progesterone  (ISO)
raloxifene  (ISO)
S-adenosyl-L-methioninate  (ISO)
S-adenosyl-L-methionine  (ISO)
sanguinarine  (ISO)
SB 431542  (ISO)
silicon dioxide  (EXP,ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
succimer  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
theophylline  (ISO)
titanium dioxide  (EXP,ISO)
TMC-120A  (ISO)
toluene 2,4-diisocyanate  (ISO)
topotecan  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vitamin E  (ISO)
zaragozic acid A  (EXP,ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
4. Essential role of lymph nodes in contact hypersensitivity revealed in lymphotoxin-alpha-deficient mice. Rennert PD, etal., J Exp Med. 2001 Jun 4;193(11):1227-38.
5. GOA pipeline RGD automated data pipeline
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Differential activities of secreted lymphotoxin-alpha3 and membrane lymphotoxin-alpha1beta2 in lymphotoxin-induced inflammation: critical role of TNF receptor 1 signaling. Sacca R, etal., J Immunol 1998 Jan 1;160(1):485-91.
8. Membrane lymphotoxin contributes to anti-leishmanial immunity by controlling structural integrity of lymphoid organs. Wilhelm P, etal., Eur J Immunol. 2002 Jul;32(7):1993-2003.
9. Lymphotoxin alpha beta 2 (membrane lymphotoxin) is critically important for resistance to Leishmania major infection in mice. Xu G, etal., J Immunol. 2007 Oct 15;179(8):5358-66.
Additional References at PubMed
PMID:12477932   PMID:16246198  


Genomics

Comparative Map Data
Ltb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8203,632,209 - 3,634,054 (-)NCBIGRCr8
mRatBN7.2203,627,536 - 3,629,381 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl203,627,537 - 3,629,381 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx204,327,296 - 4,329,142 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0203,689,354 - 3,691,200 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0204,226,971 - 4,228,817 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0205,184,631 - 5,186,476 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl205,184,515 - 5,186,503 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl204,861,335 - 4,863,198 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0206,941,753 - 6,943,598 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4203,666,524 - 3,668,369 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1203,666,751 - 3,668,596 (-)NCBI
Celera204,396,109 - 4,397,954 (+)NCBICelera
Cytogenetic Map20p12NCBI
LTB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38631,580,558 - 31,582,425 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl631,580,525 - 31,582,522 (-)EnsemblGRCh38hg38GRCh38
GRCh37631,548,335 - 31,550,202 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36631,656,314 - 31,658,181 (-)NCBINCBI36Build 36hg18NCBI36
Build 34631,656,313 - 31,658,181NCBI
Celera633,146,550 - 33,148,417 (-)NCBICelera
Cytogenetic Map6p21.33NCBI
HuRef631,335,069 - 31,336,936 (-)NCBIHuRef
CHM1_1631,550,467 - 31,552,334 (-)NCBICHM1_1
T2T-CHM13v2.0631,433,610 - 31,435,477 (-)NCBIT2T-CHM13v2.0
Ltb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391735,413,483 - 35,415,281 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1735,413,415 - 35,415,296 (+)EnsemblGRCm39 Ensembl
GRCm381735,194,507 - 35,196,305 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1735,194,439 - 35,196,320 (+)EnsemblGRCm38mm10GRCm38
MGSCv371735,331,452 - 35,333,250 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361734,802,574 - 34,804,354 (+)NCBIMGSCv36mm8
Celera1738,291,216 - 38,293,014 (+)NCBICelera
Cytogenetic Map17B1NCBI
cM Map1718.59NCBI
Ltb
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_004955437120,966 - 123,973 (-)NCBIChiLan1.0ChiLan1.0
LTB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2546,057,500 - 46,060,073 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1642,019,081 - 42,024,574 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0631,241,643 - 31,244,454 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1632,131,607 - 32,133,468 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl632,131,760 - 32,133,467 (-)Ensemblpanpan1.1panPan2
LTB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1121,079,340 - 1,084,785 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl121,079,358 - 1,081,153 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha121,215,801 - 1,217,596 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0121,224,605 - 1,226,400 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl121,224,605 - 1,226,400 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1121,083,338 - 1,085,125 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0121,151,270 - 1,153,063 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0121,218,053 - 1,219,848 (-)NCBIUU_Cfam_GSD_1.0
Ltb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494635,628,995 - 35,650,426 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367271,910,881 - 1,932,356 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367271,929,533 - 1,932,339 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LTB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl723,704,841 - 23,706,745 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1723,704,842 - 23,707,036 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2727,545,187 - 27,547,163 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LTB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Vero_WHO_p1.0NW_02366604431,482,890 - 31,485,770 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ltb
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475424,618,888 - 24,620,448 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ltb
44 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:144
Count of miRNA genes:113
Interacting mature miRNAs:127
Transcripts:ENSRNOT00000001108
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61472Aia1Adjuvant induced arthritis QTL 1180.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)2026463954597031Rat
2306850Pia40Pristane induced arthritis QTL 400.0001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)2015279595304575Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20153065546530655Rat
2317057Aia27Adjuvant induced arthritis QTL 272.83joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)20289259726381954Rat
7387283Uae44Urinary albumin excretion QTL 440.1712urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)20126123605Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20136600972Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20152784246527842Rat
1354642Despr15Despair related QTL 150.0027locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)20124159021Rat
1600382Edcs3Endometrial carcinoma susceptibility QTL33.50.003uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)20125159026Rat
61448Ciaa1CIA Autoantibody QTL 1300.001blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)2026463954597031Rat
1331772Cdexp2CD45RC expression in CD8 T cells QTL 25.7CD8-positive T cell quantity (VT:0008077)blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)20362164910078919Rat
8694189Bw153Body weight QTL 1533.130.001body mass (VT:0001259)body weight gain (CMO:0000420)20129191651Rat
1300152Bp195Blood pressure QTL 1953.46arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2036216499243559Rat
9590109Sffal8Serum free fatty acids level QTL 85.320.01blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)20129191651Rat
9590275Scort15Serum corticosterone level QTL 153.480.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20129191651Rat
9589155Insul32Insulin level QTL 326.380.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20129191651Rat
7411650Foco23Food consumption QTL 2320.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20129191651Rat
2317851Alcrsp22Alcohol response QTL 223.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
1598816Memor12Memory QTL 122.4exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)20260683647606836Rat
61432Cia1Collagen induced arthritis QTL 1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)20362165614101050Rat
1641893Alcrsp7Alcohol response QTL 7response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
6893685Bw111Body weight QTL 1112.70.004body mass (VT:0001259)body weight (CMO:0000012)20132578807Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20136600972Rat
737973Pia21Pristane induced arthritis QTL 214.8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)2036216564606812Rat

Markers in Region
RH127662  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2203,627,637 - 3,627,847 (+)MAPPERmRatBN7.2
mRatBN7.2203,627,637 - 3,627,847 (-)MAPPERmRatBN7.2
Rnor_6.0205,186,165 - 5,186,374NCBIRnor6.0
Rnor_6.0204,861,455 - 4,861,664NCBIRnor6.0
Rnor_5.0206,941,855 - 6,942,064UniSTSRnor5.0
RGSC_v3.4203,666,626 - 3,666,835UniSTSRGSC3.4
Celera204,397,643 - 4,397,852UniSTS
RH 3.4 Map2051.3UniSTS
Cytogenetic Map20p12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
17 3 14 55 76 79 29 43 29 12 146 84 30 15 38 50

Sequence


Ensembl Acc Id: ENSRNOT00000001108   ⟹   ENSRNOP00000001108
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl203,627,537 - 3,629,381 (-)Ensembl
Rnor_6.0 Ensembl204,861,353 - 4,863,198 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000079503   ⟹   ENSRNOP00000069775
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl204,861,335 - 4,863,011 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000089411   ⟹   ENSRNOP00000072122
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl205,184,515 - 5,186,503 (+)Ensembl
RefSeq Acc Id: NM_212507   ⟹   NP_997672
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8203,632,209 - 3,634,054 (-)NCBI
mRatBN7.2203,627,536 - 3,629,381 (-)NCBI
Rnor_6.0205,184,631 - 5,186,476 (+)NCBI
Rnor_5.0206,941,753 - 6,943,598 (-)NCBI
RGSC_v3.4203,666,524 - 3,668,369 (-)RGD
Celera204,396,109 - 4,397,954 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_997672 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH88208 (Get FASTA)   NCBI Sequence Viewer  
  CAE84002 (Get FASTA)   NCBI Sequence Viewer  
  EDL83546 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000001108.3
RefSeq Acc Id: NP_997672   ⟸   NM_212507
- UniProtKB: Q6MG45 (UniProtKB/TrEMBL),   F7EMS9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000072122   ⟸   ENSRNOT00000089411
Ensembl Acc Id: ENSRNOP00000069775   ⟸   ENSRNOT00000079503
Ensembl Acc Id: ENSRNOP00000001108   ⟸   ENSRNOT00000001108
Protein Domains
THD

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6MG45-F1-model_v2 AlphaFold Q6MG45 1-306 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1303162 AgrOrtholog
BioCyc Gene G2FUF-4659 BioCyc
Ensembl Genes ENSRNOG00000000836 Ensembl
  ENSRNOG00000058566 Ensembl
  ENSRNOG00000070531 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000001108.6 UniProtKB/TrEMBL
Gene3D-CATH 2.60.120.40 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7381953 IMAGE-MGC_LOAD
InterPro TNF_a/b/c UniProtKB/TrEMBL
  TNF_C UniProtKB/TrEMBL
  TNF_CS UniProtKB/TrEMBL
  TNF_family UniProtKB/TrEMBL
  Tumour_necrosis_fac-like UniProtKB/TrEMBL
KEGG Report rno:361795 UniProtKB/TrEMBL
MGC_CLONE MGC:108924 IMAGE-MGC_LOAD
NCBI Gene 361795 ENTREZGENE
PANTHER PTHR11471:SF29 UniProtKB/TrEMBL
  TUMOR NECROSIS FACTOR FAMILY MEMBER UniProtKB/TrEMBL
Pfam TNF UniProtKB/TrEMBL
PhenoGen Ltb PhenoGen
PRINTS TNECROSISFCT UniProtKB/TrEMBL
  TNFC UniProtKB/TrEMBL
PROSITE TNF_1 UniProtKB/TrEMBL
  TNF_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000000836 RatGTEx
  ENSRNOG00000058566 RatGTEx
  ENSRNOG00000070531 RatGTEx
SMART TNF UniProtKB/TrEMBL
Superfamily-SCOP TNF_like UniProtKB/TrEMBL
UniProt F7EMS9 ENTREZGENE, UniProtKB/TrEMBL
  Q6MG45 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Ltb  lymphotoxin beta  LOC103694381  lymphotoxin-beta  Data merged from RGD:9083628 737654 PROVISIONAL
2015-11-30 Ltb  lymphotoxin beta  Ltb  lymphotoxin beta (TNF superfamily, member 3)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2014-08-25 LOC103694381  lymphotoxin-beta      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-09-18 Ltb  lymphotoxin beta (TNF superfamily, member 3)  Ltb  lymphotoxin B  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-07-14 Ltb  lymphotoxin B      Symbol and Name status set to provisional 70820 PROVISIONAL