Gsn (gelsolin) - Rat Genome Database

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Gene: Gsn (gelsolin) Rattus norvegicus
Symbol: Gsn
Name: gelsolin
RGD ID: 1303089
Description: Enables actin binding activity. Involved in several processes, including actin filament depolymerization; oligodendrocyte development; and positive regulation of p38MAPK cascade. Located in several cellular components, including apical ectoplasmic specialization; basal ectoplasmic specialization; and cytoskeleton. Part of protein-containing complex. Biomarker of hypothyroidism; lung disease; and myocardial infarction. Human ortholog(s) of this gene implicated in Finnish type amyloidosis. Orthologous to human GSN (gelsolin); PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; N-cadherin signaling pathway; Fc gamma receptor mediated signaling pathway; INTERACTS WITH 1,3-dinitrobenzene; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
Previously known as: actin-depolymerizing factor; ADF; brevin; MGC95032
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr8338,982,605 - 39,035,849 (+)NCBIGRCr8
mRatBN7.2318,585,166 - 18,638,404 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl318,585,172 - 18,638,402 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx321,683,799 - 21,710,538 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0330,268,837 - 30,295,574 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0328,522,714 - 28,549,446 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0314,456,106 - 14,508,922 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl314,467,330 - 14,508,911 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0319,773,655 - 19,826,463 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4314,360,245 - 14,386,313 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1314,256,616 - 14,282,685 (+)NCBI
Celera313,325,045 - 13,351,501 (+)NCBICelera
Cytogenetic Map3p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3-dinitrobenzene  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3-dimethoxynaphthalene-1,4-dione  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,5-hexanedione  (EXP)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
acetylsalicylic acid  (EXP)
acrylamide  (EXP)
aflatoxin B1  (EXP,ISO)
Aflatoxin B2 alpha  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
aminoglutethimide  (ISO)
amiodarone  (EXP)
arabinogalactan  (EXP)
aristolochic acid A  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
bilirubin IXalpha  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bleomycin A2  (EXP)
butyric acid  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
cantharidin  (ISO)
carbon nanotube  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
cocaine  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
cumene  (ISO)
Cuprizon  (EXP,ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
D-glucose  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (ISO)
diclofenac  (ISO)
diethyl maleate  (ISO)
dimethylselenide  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
fipronil  (EXP)
folic acid  (ISO)
fulvestrant  (ISO)
furan  (EXP)
genistein  (EXP)
gentamycin  (EXP)
glucose  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
GW 4064  (ISO)
hyaluronic acid  (EXP)
hydralazine  (ISO)
hydrogen peroxide  (EXP,ISO)
hydroxyl  (ISO)
indole-3-methanol  (EXP)
indometacin  (ISO)
inulin  (ISO)
ivermectin  (ISO)
lead(0)  (ISO)
lipopolysaccharide  (ISO)
medroxyprogesterone acetate  (ISO)
menadione  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
metformin  (ISO)
methotrexate  (ISO)
methylmercury chloride  (ISO)
methylseleninic acid  (ISO)
microcystin-LR  (ISO)
Muraglitazar  (EXP)
N-nitrosodimethylamine  (ISO)
navitoclax  (ISO)
nickel atom  (ISO)
nickel sulfate  (ISO)
nitric oxide  (ISO)
nitroglycerin  (EXP)
ozone  (ISO)
p-menthan-3-ol  (ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
PCB138  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
phenethyl isothiocyanate  (ISO)
phenobarbital  (ISO)
phenylhydrazine  (ISO)
pirinixic acid  (ISO)
potassium dichromate  (ISO)
progesterone  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (EXP,ISO)
sodium fluoride  (ISO)
Sodium salicylate  (ISO)
Soman  (EXP)
succimer  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
tamibarotene  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
Tesaglitazar  (EXP)
testosterone  (ISO)
tetrachloromethane  (ISO)
tetrahydropalmatine  (ISO)
thapsigargin  (EXP)
titanium dioxide  (ISO)
toxaphene  (ISO)
trichostatin A  (EXP,ISO)
troglitazone  (EXP,ISO)
urethane  (ISO)
valproic acid  (ISO)
verapamil  (EXP)
vinclozolin  (EXP)
vitamin E  (ISO)
vorinostat  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
actin cytoskeleton organization  (ISO)
actin filament capping  (ISO)
actin filament depolymerization  (IEA,IMP,ISO)
actin filament organization  (ISO)
actin filament polymerization  (IEA,ISO,ISS)
actin filament severing  (IBA,IEA,ISO,ISS)
actin polymerization or depolymerization  (IBA,IDA,IEA)
amyloid fibril formation  (IEA,ISO)
barbed-end actin filament capping  (IBA,IEA)
cardiac muscle cell contraction  (IEA,ISO)
cell projection assembly  (IBA)
cellular response to cadmium ion  (IDA)
cellular response to type II interferon  (IEA,ISO)
central nervous system development  (IBA,IEA)
cilium assembly  (IEA,ISO,ISS)
extracellular matrix disassembly  (ISO)
hepatocyte apoptotic process  (IEA,ISO)
negative regulation of viral entry into host cell  (IEA)
oligodendrocyte development  (IEP)
phagocytosis, engulfment  (IEA,ISO)
positive regulation of actin nucleation  (IEA,ISO)
positive regulation of cardiac muscle hypertrophy  (IMP)
positive regulation of gene expression  (ISO)
positive regulation of keratinocyte apoptotic process  (IEA,ISO)
positive regulation of p38MAPK cascade  (IMP)
positive regulation of protein processing in phagocytic vesicle  (IEA,ISO)
protein destabilization  (IEA,ISO)
regulation of establishment of T cell polarity  (IEA,ISO)
regulation of plasma membrane raft polarization  (IEA,ISO)
regulation of podosome assembly  (IEA,ISO)
regulation of receptor clustering  (IEA,ISO)
relaxation of cardiac muscle  (IEA,ISO)
renal protein absorption  (IEA,ISO)
response to ethanol  (IEP)
response to folic acid  (IEP)
response to muscle stretch  (IEA,ISO)
sequestering of actin monomers  (IEA,ISO)
striated muscle atrophy  (IEA,ISO)
tissue regeneration  (IEP)
vesicle-mediated transport  (ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View

References - curated
# Reference Title Reference Citation
1. Aging-associated increase of gelsolin for apoptosis resistance. Ahn JS, etal., Biochem Biophys Res Commun 2003 Dec 26;312(4):1335-41.
2. Involvement of gelsolin in cadmium-induced disruption of the mesangial cell cytoskeleton. Apostolova MD, etal., Toxicol Sci. 2006 Feb;89(2):465-74. Epub 2005 Nov 9.
3. Plasma gelsolin as a biomarker of acute rheumatic carditis. Argun M, etal., Cardiol Young. 2015 Oct;25(7):1276-80. doi: 10.1017/S1047951114002327. Epub 2014 Nov 18.
4. Widespread loss of gelsolin in breast cancers of humans, mice, and rats. Asch HL, etal., Cancer Res. 1996 Nov 1;56(21):4841-5.
5. Pulmonary vascular permeability and ischemic injury in gelsolin-deficient mice. Becker PM, etal., Am J Respir Cell Mol Biol. 2003 Apr;28(4):478-84. doi: 10.1165/rcmb.2002-0024OC.
6. Altered plasma-type gelsolin and amyloid-β in neonates with hypoxic-ischaemic encephalopathy under therapeutic hypothermia. Benavente-Fernandez I, etal., J Cereb Blood Flow Metab. 2019 Jul;39(7):1349-1354. doi: 10.1177/0271678X18757419. Epub 2018 Feb 21.
7. Modulation of gelsolin content in rat aortic smooth muscle cells during development, experimental intimal thickening and culture. An immunohistochemical and biochemical study. Chaponnier C, etal., Eur J Biochem. 1990 Jul 5;190(3):559-65.
8. Gelsolin and Progression of Aortic Arch Calcification in Chronic Hemodialysis Patients. Chiou TT, etal., Int J Med Sci. 2016 Jan 29;13(2):92-8. doi: 10.7150/ijms.13785. eCollection 2016.
9. Neuroprotective effects of gelsolin during murine stroke. Endres M, etal., J Clin Invest. 1999 Feb;103(3):347-54. doi: 10.1172/JCI4953.
10. Effect of prenatal exposure to ethanol on hepatic elongation factor-2 and proteome in 21 d old rats: protective effect of folic acid. Garcia-Rodriguez S, etal., Free Radic Biol Med. 2003 Aug 15;35(4):428-37.
11. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
12. The cytoskeleton in 'couch potato-ism': Insights from a murine model of impaired actin dynamics. Gertz K, etal., Exp Neurol. 2018 Aug;306:34-44. doi: 10.1016/j.expneurol.2018.04.004. Epub 2018 Apr 21.
13. Plasma gelsolin levels and 1-year mortality after first-ever ischemic stroke. Guo XC, etal., J Crit Care. 2011 Dec;26(6):608-12. doi: 10.1016/j.jcrc.2011.02.007. Epub 2011 Apr 9.
14. Protective effects of gelsolin in acute pulmonary thromboembolism and thrombosis in the carotid artery of mice. Gupta AK, etal., PLoS One. 2019 Apr 19;14(4):e0215717. doi: 10.1371/journal.pone.0215717. eCollection 2019.
15. Gelsolin--evidence for a role in turnover of junction-related actin filaments in Sertoli cells. Guttman JA, etal., J Cell Sci 2002 Feb 1;115(Pt 3):499-505.
16. Oral administration of alcalase potato protein hydrolysate-APPH attenuates high fat diet-induced cardiac complications via TGF-β/GSN axis in aging rats. Hu WS, etal., Environ Toxicol. 2019 Jan;34(1):5-12. doi: 10.1002/tox.22651. Epub 2018 Sep 21.
17. Gelsolin (GSN) induces cardiomyocyte hypertrophy and BNP expression via p38 signaling and GATA-4 transcriptional factor activation. Hu WS, etal., Mol Cell Biochem. 2014 May;390(1-2):263-70. doi: 10.1007/s11010-014-1977-7. Epub 2014 Feb 7.
18. High gelsolin content of developing oligodendrocytes. Lena JY, etal., Int J Dev Neurosci. 1994 Aug;12(5):375-86.
19. Mutation in gelsolin gene in Finnish hereditary amyloidosis. Levy E, etal., J Exp Med. 1990 Dec 1;172(6):1865-7.
20. Gelsolin regulates cardiac remodeling after myocardial infarction through DNase I-mediated apoptosis. Li GH, etal., Circ Res. 2009 Apr 10;104(7):896-904. doi: 10.1161/CIRCRESAHA.108.172882. Epub 2009 Feb 26.
21. Larch Arabinogalactan Attenuates Myocardial Injury by Inhibiting Apoptotic Cascades in a Rat Model of Ischemia-Reperfusion. Lim SH, J Med Food. 2017 Jul;20(7):691-699. doi: 10.1089/jmf.2016.3886. Epub 2017 Jun 16.
22. Evidence for apoptosis after intercerebral hemorrhage in rat striatum. Matsushita K, etal., J Cereb Blood Flow Metab. 2000 Feb;20(2):396-404.
23. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
24. Gene expression profile changes are commonly modulated across models and species after traumatic brain injury. Natale JE, etal., J Neurotrauma. 2003 Oct;20(10):907-27.
25. Gelsolin gene expression is upregulated in damaged rat and human livers within non-parenchymal cells and not in hepatocytes. Neubauer K, etal., Histochem Cell Biol. 2003 Oct;120(4):265-75. Epub 2003 Aug 28.
26. Identification of a multiprotein "motor" complex binding to water channel aquaporin-2. Noda Y, etal., Biochem Biophys Res Commun. 2005 May 20;330(4):1041-7.
27. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
28. Plasma gelsolin levels and outcomes after aneurysmal subarachnoid hemorrhage. Pan JW, etal., Crit Care. 2013 Jul 23;17(4):R149. doi: 10.1186/cc12828.
29. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
30. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
31. Gelsolin immunoreactivity and development of the tectorial membrane in the cochlea of normal and hypothyroid rats. Rabie A, etal., Cell Tissue Res. 1988 Oct;254(1):241-5.
32. GOA pipeline RGD automated data pipeline
33. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
34. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
35. Lack of gelsolin promotes perpetuation of atrial fibrillation in the mouse heart. Schrickel JW, etal., J Interv Card Electrophysiol. 2009 Oct;26(1):3-10. doi: 10.1007/s10840-009-9425-4. Epub 2009 Aug 8.
36. Cognitive Impairment and Brain and Peripheral Alterations in a Murine Model of Intraventricular Hemorrhage in the Preterm Newborn. Segado-Arenas A, etal., Mol Neurobiol. 2018 Jun;55(6):4896-4910. doi: 10.1007/s12035-017-0693-1. Epub 2017 Jul 28.
37. Allele-specific expression in the human heart and its application to postoperative atrial fibrillation and myocardial ischemia. Sigurdsson MI, etal., Genome Med. 2016 Dec 6;8(1):127. doi: 10.1186/s13073-016-0381-1.
38. Circulating actin-gelsolin complexes following oleic acid-induced lung injury. Smith DB, etal., Am J Pathol. 1988 Feb;130(2):261-7.
39. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
40. Decreased plasma gelsolin concentrations in acute liver failure, myocardial infarction, septic shock, and myonecrosis. Suhler E, etal., Crit Care Med. 1997 Apr;25(4):594-8. doi: 10.1097/00003246-199704000-00007.
41. Investigation of the actin scavenging system in pre-eclampsia. Tannetta DS, etal., Eur J Obstet Gynecol Reprod Biol. 2014 Jan;172:32-5. doi: 10.1016/j.ejogrb.2013.10.022. Epub 2013 Oct 25.
42. Expression of Cytoplasmic Gelsolin in Rat Brain After Experimental Subarachnoid Hemorrhage. Xie GB, etal., Cell Mol Neurobiol. 2015 Jul;35(5):723-31. doi: 10.1007/s10571-015-0168-8. Epub 2015 Mar 6.
43. Two-dimensional electrophoresis with cationic detergents: a powerful tool for the proteomic analysis of myelin proteins. Part 2: analytical aspects. Yamaguchi Y, etal., J Neurosci Res. 2008 Mar;86(4):766-75.
44. Inhibition of histone deacetylation protects wildtype but not gelsolin-deficient mice from ischemic brain injury. Yildirim F, etal., Exp Neurol. 2008 Apr;210(2):531-42. doi: 10.1016/j.expneurol.2007.11.031. Epub 2007 Dec 23.
45. Significant reduction of plasma gelsolin levels in patients with intracerebral hemorrhage. Zhao DQ, etal., Clin Chim Acta. 2013 Jan 16;415:202-6. doi: 10.1016/j.cca.2012.10.048. Epub 2012 Nov 7.
Additional References at PubMed
PMID:3020431   PMID:11514591   PMID:14596804   PMID:15294161   PMID:15591047   PMID:16261560   PMID:17950082   PMID:18266911   PMID:18287947   PMID:19056867   PMID:19144319   PMID:19199708  
PMID:19549824   PMID:19666531   PMID:19904968   PMID:20393563   PMID:20458337   PMID:21362503   PMID:21423176   PMID:22199233   PMID:22516433   PMID:22553113   PMID:22871113   PMID:22952982  
PMID:23325791   PMID:23376485   PMID:23533145   PMID:23575248   PMID:23729654   PMID:24006456   PMID:24236012   PMID:24601799   PMID:24625528   PMID:25002582   PMID:26224859   PMID:27068509  
PMID:27193608   PMID:28193690   PMID:29476059   PMID:35352799  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr8338,982,605 - 39,035,849 (+)NCBIGRCr8
mRatBN7.2318,585,166 - 18,638,404 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl318,585,172 - 18,638,402 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx321,683,799 - 21,710,538 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0330,268,837 - 30,295,574 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0328,522,714 - 28,549,446 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0314,456,106 - 14,508,922 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl314,467,330 - 14,508,911 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0319,773,655 - 19,826,463 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4314,360,245 - 14,386,313 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1314,256,616 - 14,282,685 (+)NCBI
Celera313,325,045 - 13,351,501 (+)NCBICelera
Cytogenetic Map3p11NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh389121,201,483 - 121,332,842 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9121,207,794 - 121,332,843 (+)EnsemblGRCh38hg38GRCh38
GRCh379123,963,761 - 124,095,120 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369123,070,201 - 123,134,941 (+)NCBINCBI36Build 36hg18NCBI36
Build 349121,109,960 - 121,174,674NCBI
Celera994,678,898 - 94,743,628 (+)NCBICelera
Cytogenetic Map9q33.2NCBI
HuRef993,648,171 - 93,712,883 (+)NCBIHuRef
CHM1_19124,177,269 - 124,242,004 (+)NCBICHM1_1
T2T-CHM13v2.09133,397,510 - 133,528,852 (+)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39235,146,371 - 35,197,914 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl235,146,392 - 35,197,904 (+)EnsemblGRCm39 Ensembl
GRCm38235,256,359 - 35,307,902 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl235,256,380 - 35,307,892 (+)EnsemblGRCm38mm10GRCm38
MGSCv37235,137,960 - 35,163,412 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36235,104,449 - 35,129,901 (+)NCBIMGSCv36mm8
Celera234,977,113 - 35,002,613 (+)NCBICelera
Cytogenetic Map2BNCBI
cM Map223.5NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_0049554196,682,058 - 6,733,361 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554196,682,202 - 6,733,361 (-)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan1-v21118,011,809 - 18,076,682 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1918,014,159 - 18,079,040 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0992,413,819 - 92,460,483 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19120,741,148 - 120,805,831 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9120,741,148 - 120,805,831 (+)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.11174,248,227 - 74,268,129 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1174,233,457 - 74,268,129 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1172,637,556 - 72,678,974 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01175,364,194 - 75,405,704 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1175,364,181 - 75,405,705 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11173,871,291 - 73,912,586 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01173,902,056 - 73,943,469 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01174,663,262 - 74,683,140 (+)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_024404947189,981,162 - 190,034,252 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364879,764,944 - 9,802,841 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364879,749,755 - 9,802,787 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl1261,307,008 - 261,372,848 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11261,295,711 - 261,372,848 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21293,381,825 - 293,388,559 (-)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.11218,253,079 - 18,317,285 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1218,253,324 - 18,285,938 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603524,700,374 - 24,764,693 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_00462476013,943,888 - 13,969,905 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476013,943,680 - 14,004,660 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Gsn
457 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:34
Count of miRNA genes:30
Interacting mature miRNAs:34
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70202Alc19Alcohol consumption QTL 192.5drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)3127494778Rat
631679Cm10Cardiac mass QTL 107.340.0001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3131158234Rat
631831Alc8Alcohol consumption QTL 82.7consumption behavior trait (VT:0002069)calculated ethanol drink intake rate (CMO:0001615)3133230976Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)diastolic blood pressure (CMO:0000005)3133278763Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)3133278763Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)pulse pressure (CMO:0000292)3133278763Rat
631545Bp85Blood pressure QTL 853.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3133278763Rat
4889966Bss95Bone structure and strength QTL 954.4tibia area (VT:1000281)tibia-fibula cross-sectional area (CMO:0001718)3136847613Rat
2312664Scl62Serum cholesterol level QTL 620.05blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)3138710544Rat
631568Bp92Blood pressure QTL 922.20.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3139874793Rat
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)3191609953Rat
1298526Arunc3Aerobic running capacity QTL 32.2exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)3822719433703538Rat
10401810Kidm53Kidney mass QTL 53kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3822719447233430Rat
70203Gcr2Gastric cancer resistance QTL 22.6stomach morphology trait (VT:0000470)stomach tumor susceptibility score (CMO:0002043)3865816227494778Rat
1358357Srcrtb1Stress Responsive Cort Basal QTL 16.360.002blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)3865816227494778Rat
6893355Bw101Body weight QTL 1010.40.38body mass (VT:0001259)body weight (CMO:0000012)31077870430357018Rat
6893363Bw105Body weight QTL 1052.60.0036body mass (VT:0001259)body weight (CMO:0000012)31077870430357018Rat
1558654Bw56Body weight QTL 564.50.0000171body mass (VT:0001259)body weight (CMO:0000012)31077870430357018Rat
70191BpQTLcluster4Blood pressure QTL cluster 43arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)31077870450302886Rat
70191BpQTLcluster4Blood pressure QTL cluster 43arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)31077870450302886Rat
1558647Cm46Cardiac mass QTL 465.40.0000055heart mass (VT:0007028)heart wet weight (CMO:0000069)31077882330356773Rat
1558650Cm48Cardiac mass QTL 4840.0001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)31077882330356773Rat
1558657Cm43Cardiac mass QTL 436.60.0000000293heart mass (VT:0007028)heart wet weight (CMO:0000069)31077882330356773Rat
1358905Hrtrt17Heart rate QTL 175.90.000014heart pumping trait (VT:2000009)heart rate (CMO:0000002)31086191289878372Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
2298542Neuinf11Neuroinflammation QTL 113.9nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)31500542276927699Rat
631676Cm8Cardiac mass QTL 87.030.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)31695470861954708Rat
634306Bp140Blood pressure QTL 1403.30.0013arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)31737470335528639Rat
634306Bp140Blood pressure QTL 1403.30.0013arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)31737470335528639Rat
634306Bp140Blood pressure QTL 1403.30.0013arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)31737470335528639Rat
634306Bp140Blood pressure QTL 1403.30.0013arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)31737470335528639Rat
634306Bp140Blood pressure QTL 1403.30.0013arterial blood pressure trait (VT:2000000)heart rate (CMO:0000002)31737470335528639Rat
634306Bp140Blood pressure QTL 1403.30.0013arterial blood pressure trait (VT:2000000)heart rate (CMO:0000002)31737470335528639Rat
634306Bp140Blood pressure QTL 1403.30.0013arterial blood pressure trait (VT:2000000)body weight (CMO:0000012)31737470335528639Rat
634306Bp140Blood pressure QTL 1403.30.0013arterial blood pressure trait (VT:2000000)body weight (CMO:0000012)31737470335528639Rat
2325840Bp345Blood pressure QTL 3450.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31831145428441896Rat
731172Bp151Blood pressure QTL 1510.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31831145447233430Rat
12879849Bw180Body weight QTL 1800.037body mass (VT:0001259)body weight (CMO:0000012)31831145447233430Rat
12879850Cm91Cardiac mass QTL 910.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)31831145447233430Rat
12879851Cm92Cardiac mass QTL 920.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)31831145447233430Rat
12879852Cm93Cardiac mass QTL 930.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)31831145447233430Rat
12879853Am5Aortic mass QTL 50.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)31831145447233430Rat
12879854Kidm63Kidney mass QTL 630.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)31831145447233430Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2318,638,181 - 18,638,364 (+)MAPPERmRatBN7.2
Rnor_6.0314,508,700 - 14,508,882NCBIRnor6.0
Rnor_5.0319,826,241 - 19,826,423UniSTSRnor5.0
RGSC_v3.4314,386,102 - 14,386,284UniSTSRGSC3.4
Celera313,351,294 - 13,351,472UniSTS
Cytogenetic Map3p11UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2318,613,055 - 18,613,121 (+)MAPPERmRatBN7.2
Rnor_6.0314,483,958 - 14,484,023NCBIRnor6.0
Rnor_5.0319,801,499 - 19,801,564UniSTSRnor5.0
RGSC_v3.4314,361,815 - 14,361,880UniSTSRGSC3.4
Celera313,326,614 - 13,326,679UniSTS
Cytogenetic Map3p11UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 3 10
Medium 3 40 45 29 19 29 8 11 70 35 41 1 8
Low 12 12 12 4
Below cutoff


RefSeq Acc Id: ENSRNOT00000025857   ⟹   ENSRNOP00000025857
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl318,611,487 - 18,638,393 (+)Ensembl
Rnor_6.0 Ensembl314,482,388 - 14,508,911 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000078939   ⟹   ENSRNOP00000075631
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl318,585,172 - 18,638,383 (+)Ensembl
Rnor_6.0 Ensembl314,467,330 - 14,508,911 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000107609   ⟹   ENSRNOP00000086188
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl318,585,192 - 18,638,391 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000108827   ⟹   ENSRNOP00000088362
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl318,612,397 - 18,638,402 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000112129   ⟹   ENSRNOP00000096124
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl318,611,406 - 18,638,402 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000114912   ⟹   ENSRNOP00000084576
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl318,585,210 - 18,638,398 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000116452   ⟹   ENSRNOP00000092845
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl318,593,302 - 18,638,369 (+)Ensembl
RefSeq Acc Id: NM_001004080   ⟹   NP_001004080
Rat AssemblyChrPosition (strand)Source
GRCr8339,008,932 - 39,035,838 (+)NCBI
mRatBN7.2318,611,487 - 18,638,393 (+)NCBI
Rnor_6.0314,482,388 - 14,508,911 (+)NCBI
Rnor_5.0319,773,655 - 19,826,463 (+)NCBI
RGSC_v3.4314,360,245 - 14,386,313 (+)RGD
Celera313,325,045 - 13,351,501 (+)RGD
RefSeq Acc Id: XM_006234040   ⟹   XP_006234102
Rat AssemblyChrPosition (strand)Source
GRCr8338,982,606 - 39,035,849 (+)NCBI
mRatBN7.2318,585,167 - 18,638,404 (+)NCBI
Rnor_6.0314,456,106 - 14,508,922 (+)NCBI
Rnor_5.0319,773,655 - 19,826,463 (+)NCBI
RefSeq Acc Id: XM_017591662   ⟹   XP_017447151
Rat AssemblyChrPosition (strand)Source
GRCr8338,982,605 - 39,035,849 (+)NCBI
mRatBN7.2318,585,166 - 18,638,404 (+)NCBI
Rnor_6.0314,456,106 - 14,508,922 (+)NCBI
RefSeq Acc Id: XM_039104784   ⟹   XP_038960712
Rat AssemblyChrPosition (strand)Source
GRCr8338,982,690 - 39,035,849 (+)NCBI
mRatBN7.2318,585,218 - 18,638,404 (+)NCBI
RefSeq Acc Id: XM_063283523   ⟹   XP_063139593
Rat AssemblyChrPosition (strand)Source
GRCr8338,982,605 - 39,035,849 (+)NCBI
RefSeq Acc Id: XM_063283524   ⟹   XP_063139594
Rat AssemblyChrPosition (strand)Source
GRCr8338,986,245 - 39,035,849 (+)NCBI
RefSeq Acc Id: NP_001004080   ⟸   NM_001004080
- Peptide Label: precursor
- UniProtKB: Q68FP1 (UniProtKB/Swiss-Prot),   A6JUE8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006234102   ⟸   XM_006234040
- Peptide Label: isoform X2
- UniProtKB: A6JUE9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017447151   ⟸   XM_017591662
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZZX4 (UniProtKB/TrEMBL),   A6JUE9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000025857   ⟸   ENSRNOT00000025857
RefSeq Acc Id: ENSRNOP00000075631   ⟸   ENSRNOT00000078939
RefSeq Acc Id: XP_038960712   ⟸   XM_039104784
- Peptide Label: isoform X2
- UniProtKB: A6JUE9 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000088362   ⟸   ENSRNOT00000108827
RefSeq Acc Id: ENSRNOP00000096124   ⟸   ENSRNOT00000112129
RefSeq Acc Id: ENSRNOP00000086188   ⟸   ENSRNOT00000107609
RefSeq Acc Id: ENSRNOP00000084576   ⟸   ENSRNOT00000114912
RefSeq Acc Id: ENSRNOP00000092845   ⟸   ENSRNOT00000116452
RefSeq Acc Id: XP_063139593   ⟸   XM_063283523
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063139594   ⟸   XM_063283524
- Peptide Label: isoform X1
Protein Domains

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q68FP1-F1-model_v2 AlphaFold Q68FP1 1-780 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13692017
Promoter ID:EPDNEW_R2541
Type:multiple initiation site
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Experiment Methods:Single-end sequencing.
Rat AssemblyChrPosition (strand)Source
Rnor_6.0314,482,370 - 14,482,430EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1303089 AgrOrtholog
BioCyc Gene G2FUF-50057 BioCyc
Ensembl Genes ENSRNOG00000018991 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055006912 UniProtKB/Swiss-Prot
  ENSRNOG00060023173 UniProtKB/Swiss-Prot
  ENSRNOG00065027129 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000025857 ENTREZGENE
  ENSRNOT00000025857.6 UniProtKB/Swiss-Prot
  ENSRNOT00000078939.2 UniProtKB/TrEMBL
  ENSRNOT00000107609.1 UniProtKB/TrEMBL
  ENSRNOT00000108827.1 UniProtKB/TrEMBL
  ENSRNOT00000112129.1 UniProtKB/TrEMBL
  ENSRNOT00000114912.1 UniProtKB/TrEMBL
  ENSRNOT00000116452.1 UniProtKB/TrEMBL
  ENSRNOT00055011391 UniProtKB/Swiss-Prot
  ENSRNOT00060040221 UniProtKB/Swiss-Prot
  ENSRNOT00065046775 UniProtKB/Swiss-Prot
Gene3D-CATH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro ADF-H/Gelsolin-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Gelsolin-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Villin/Gelsolin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:296654 UniProtKB/Swiss-Prot
  PTHR11977 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Gelsolin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Gsn PhenoGen
RatGTEx ENSRNOG00000018991 RatGTEx
  ENSRNOG00055006912 RatGTEx
  ENSRNOG00060023173 RatGTEx
  ENSRNOG00065027129 RatGTEx
SMART GEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Actin depolymerizing proteins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-03-30 Gsn  gelsolin      Symbol and Name status set to approved 1299863 APPROVED
2005-02-14 Gsn  gelsolin      Symbol and Name status set to provisional 70820 PROVISIONAL